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Dissertations / Theses on the topic 'Mitochondrial biogenesis and quality control'

Author: Grafiati

Published: 6 September 2023

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1

Jong, Liesbeth de. "Regulated assembly of the respiratory chain in Saccharomyces cerevisiae involvement of the mitochondrial NAD-linked isocitrate dehydrogenase, (AAA-)metallo-proteases and prohibitin in synthesis, quality control, turnover and stability /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/87355.

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Leung, Eileen. "Quality control in the biogenesis of the signal recognition particle." Thesis, University of Newcastle upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506530.

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3

Ostojic, Jelena. "Control of the biogenesis of the OXPHOS complexes and their interactions in Saccharomyces cerevisiae." Thesis, Evry-Val d'Essonne, 2013. http://www.theses.fr/2013EVRY0013/document.

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Le complexe III de la chaine respiratoire mitochondriale (OXPHOS III) chez S. cerevisiae est assemblé à partir de dix sous-unités structurales codées par le génome soit nucléaire, soit mitochondrial et fait intervenir une douzaine de protéines extrinsèques au complexe. Nous avons étudié l’une d’entre elle, Bcs1, une ATPase oligomérique conservée de la famille des protéines AAA (ATPases Associated with diverse cellular Activities), qui contrôle la dernière étape de l’assemblage du complexe III. Chez l’Homme, des mutations dans l’orthologue de BCS1, BCS1L, sont associées à différentes maladies.

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4

MacVicar, Thomas D. B. "Autophagy and mitochondrial quality control in homeostasis and disease." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627943.

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Mitochondria are the powerhouses of eukaryotic cells and they must remain healthy in order to generate sufficient ATP for cellular function. Dysfunctional mitochondria pose a grave threat to high-energy demanding tissues and are associated with an array of human diseases. Mitochondria exist in a dynamic organelle network that is essential for their intracellular distribution and quality control. A damaged mitochondrion must first be exiled from the network by mitochondrial fission and next be neutralized by a process termed mitophagy. A number of mitophagy pathways exist to specifically target

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5

Ling, Jiqiang. "Role of phenylalanyl-tRNA synthetase in translation quality control." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1212111223.

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6

Vigié, Pierre. "Mitochondrial quality control : roles of autophagy, mitophagy and the proteasome." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0202/document.

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La mitophagie, la dégradation sélective des mitochondries par autophagie, est impliquée dans l’élimination des mitochondries endommagées ou superflues et requiert des régulateurs et protéines spécifiques. Chez la levure, Atg32, localisée dans la membrane externe mitochondriale, interagit avec Atg8, et permet le recrutement des mitochondries et leur séquestration à l’intérieur des autophagosomes. Atg8 est conjuguée à de la phosphatidyléthanolamine et est ainsi ancrée aux membranes du phagophore et des autophagosomes. Chez la levure, plusieurs voies de synthèse de PE existent mais leur contribut

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7

Lingiah, Krishna Anand. "The role of DJ-1 in enhancing mitochondrial quality control." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12148.

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Thesis (M.A.)--Boston University<br>DJ-1 is a cytosolic sensor for oxidative damage which acts on the Mitochondria. It works to curb the negative effects of high membrane potential in mitochondria, but the mechanism of action is still uncertain. This study measured DJ-1’s potential in enchancing mitochondrial quality control in the context of pancreatic B-cells treated with a palmitate and glucose media to promote glucolipotoxicity (GLT). DJ-1 was proven capable of reversing GLT induced changed in mitochondrial morphology in the arenas of Feret’s diameter, aspect ratio, and form factor. We als

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8

Ng, Cheuk-Him (Andy). "Genome-Wide Screen Identifies Novel Genes Involved in Mitochondrial Quality Control." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33204.

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In addition to ATP generation, mitochondria are essential in various cellular processes ranging from biosynthetic pathways, apoptosis, cell cycle progression, and calcium buffering. Studies in living cells have now firmly established that mitochondria exist as a dynamic network sculpted by fission and fusion reactions, rather than separated, individual organelles. Not surprisingly, mutations in genes involved in mitochondrial dynamics and quality control lead to human diseases such as Charcot-Marie-Tooth disease type 2A, Optic atrophy, and autosomal recessive Parkinson disease. I have designed

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9

Rüb, Cornelia [Verfasser]. "The Parkinson’s disease-related kinase Pink1 mediates mitochondrial quality control / Cornelia Rüb." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1119888662/34.

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10

Eira, da Costa Ana Carina. "Analysis of mitochondrial quality control using a Drosophila model of Parkinson's disease." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28019.

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Parkinson’s disease (PD) is the most common neurodegenerative movement disorder. Despite recent advances, the cause for most PD cases remains unclear. The discovery of mutations in PINK1 (PTEN-induced putative kinase 1) reinforced the importance of mitochondrial impairment in PD. Mitochondria are essential organelles for energy generation in eukaryotic cells, whose compromise can eventually cause cell death. Multicellular organisms have evolved quality control mechanisms to ensure the viability of mitochondria and ultimately the cell. Molecular quality control through the mitochondrial chapero

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11

Franco, Iborra Sandra. "Mitochondrial quality control in neurodegenerative diseases: focus on Parkinson’s disease and Huntington’s disease." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/565668.

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Darrerament s’han produït avanços importants que han contribuït al coneixement dels mecanismes de disfunció cel·lular i mort en la malaltia de Parkinson (MP) i en la malaltia de Huntington (MH). Ambdues malalties són trastorns del moviment que es caracteritzen per la pèrdua específica de neurones dels ganglis basals, les neurones dopaminèrgiques de la substància nigra (SN), en el cas de la MP i les neurones espinoses de l’estriat, en el cas de la MH. Malgrat les diferències, ambdues comparteixen processos patològics comuns com la presència de proteïnes malplegades, l’estrés oxidatiu i disfunci

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12

Ambivero, Camilla. "The Role of Mitochondrial Omi/HtrA2 Protease in Protein Quality Control and Mitophagy." Doctoral diss., University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5754.

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Omi/HtrA2 is a nuclear encoded mitochondrial serine protease with dual and opposite functions that depend entirely on its subcellular localization. During apoptosis it is released to the cytoplasm where it participates in cell death. While confined in the mitochondria it has a pro-survival function that may involve the regulation of protein quality control (PQC) and mitochondrial homeostasis. We used the yeast two-hybrid system to dissect Omi/HtrA2's pathway by identifying novel interactors and substrates. Our studies revealed a novel function of Omi/HtrA2 in the regulation of a Lys-63 deubiqu

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13

Barrio, Garcia Clara [Verfasser], and Roland [Akademischer Betreuer] Beckmann. "Structural view on 60S ribosome biogenesis : remodeling and quality control mechanisms / Clara Barrio Garcia ; Betreuer: Roland Beckmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1115144901/34.

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Malnoë, Alizée. "A genetic suppressor approach to the biogenesis, quality control and function of photosynthetic complexes in Chlamydomonas reinhardtii." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-01057821.

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Central in oxygenic photosynthesis, the cytochrome b6f complex, couples electron transfer to proton translocation across the thylakoid membrane via its quinol:plastocyanin oxidoreductase activity, contributing to ATP formation. Cytochrome b6f complex differs from its respiratory homolog, the bc1 complex, by the presence of an additional heme, heme ci located within the quinone reduction site Qi and attached by a unique thioether bond. Mutants lacking heme ci show low accumulation of partially functional b6f complex and, hence, cannot grow phototrophically. This grounded a screen for suppressor

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15

Dashti, Eman. "Role of receptor mediated endocytosis-8, a novel Parkinson's disease gene, in mitochondrial quality control." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121496.

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Over the past two decades, significant understanding of the pathogenesis of Parkinson's disease (PD) has been attributed to the discovery of genes, that when mutated, are responsible for familial forms of PD. Recently a novel autosomal dominant mutation (AD) causing PD was identified in receptor-mediated endocytosis-8 (RME-8). When mutated, symptoms of PD manifest with an onset ~ 70 years of age. RME-8 is a DnaJ domain containing protein that plays an important role in intercellular trafficking and recycling of retrograde cargo. Loss of function of RME-8 disrupts the endosome to Golgi transpor

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16

Remenaric, Hajak Mateja. "Study of ribonucleoprotein particle biogenesis and quality control by a novel technique using bacterial Rho factor as a tool." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2013/document.

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Chez les eucaryotes, l’information génétique est transcrite en ARN messager qui subit plusieurs étapes de maturation et évènements d’assemblage avant d’être exporté hors du noyau. Ces modifications du transcrit sont effectuées par de nombreux facteurs protéiques recrutés au transcrit naissant, formant ainsi une particule ribonucléoprotéique (mRNP). La biogenèse du mRNP est étroitement liée avec la transcription et le contrôle qualité afin d’assurer l’efficacité et l’exactitude de la production de mRNPs matures. Des études récentes suggèrent que les membres du complexe THO-Sub2 pourraient être

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17

Yadavalli, Srujana Samhita. "ROLE OF PHENYLALANYL-TRNA SYNTHETASE IN AMINOACYLATION AND TRANSLATION QUALITY CONTROL." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338149688.

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18

Magosi, Lerato E. "Role of Snx9 in the Regulation of Mitochondrial Morphology." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22924.

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Mitochondria are dynamic; they alter their shape through fission, fusion and budding of vesicles. Mitochondrial vesicles serve as a quality control mechanism enabling these organelles to rid themselves of damaged lipids and proteins. Dysregulation in mitochondrial dynamics and quality control have been linked to Parkinson’s Disease, making the identification of molecules requisite for these processes a priority. We identified the endocytic protein, Sorting nexin 9 (Snx9) through a genome wide siRNA screen for genes which substantially alter mitochondrial morphology and therefore are important

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19

MAGRI, STEFANIA. "Functional analysis of m-AAA homo- and heterocomplexes: the role of mitochondrial protein quality control system in spinocerebellar neurodegeneration." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/29913.

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Autosomal dominant spinocerebellar ataxias (SCA) are a heterogeneous group of neurological disorders characterized by cerebellar dysfunction. We recently showed that AFG3L2 mutations cause dominant ataxia SCA28. AFG3L2 and its partner protein paraplegin, which causes recessive spastic paraparesis SPG7, are components of the m-AAA complex, involved in mitochondrial protein quality control. Since yeast functional studies showed that paraplegin coexpression can modulate AFG3L2 mutations, we investigated the possible coinheritance of AFG3L2 and SPG7 mutations in patients with spinocerebellar syndr

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20

Georgakopoulos, N. D. "The development of direct inhibitors of the Keap1-Nrf2 protein-protein interaction as modulators of mitochondrial function and quality control." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1558881/.

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21

Barrera, Estevez Michael [Verfasser], Andreas Akademischer Betreuer] [Gutachter] Reichert, and Amparo [Gutachter] [Acker-Palmer. "Functional role of OPA1 in mitochondrial membrane structure and quality control / Michael Barrera Estevez. Betreuer: Andreas Reichert. Gutachter: Amparo Acker-Palmer ; Andreas Reichert." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2016. http://d-nb.info/1112601430/34.

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Barrera, Estevez Michael Verfasser], Andreas [Akademischer Betreuer] [Gutachter] Reichert, and Amparo [Gutachter] [Acker-Palmer. "Functional role of OPA1 in mitochondrial membrane structure and quality control / Michael Barrera Estevez. Betreuer: Andreas Reichert. Gutachter: Amparo Acker-Palmer ; Andreas Reichert." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2016. http://d-nb.info/1112601430/34.

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23

Paradis, Marie [Verfasser]. "Characterization of the functional role of the Cystein-rich with EGF-like domains (Creld) protein in mitochondrial quality control in Drosophila melanogaster / Marie Paradis." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1218301198/34.

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24

Stanthakos, Petros. "An in vitro model for the investigation of mitochondrial dynamics and quality control in Parkinson's disease using human pluripotent stem sell-derived midbrain dopamine neurons." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.743004.

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25

Junior, Aloisio Coelho. "Implicações da variabilidade genética de Trichogramma pretiosum Riley, 1879 no seu desempenho como agente de controle biológico." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/11/11146/tde-22092015-113029/.

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O conhecimento das implicações da variabilidade genética em populações de inimigos naturais, principalmente parasitoides, é de vital importância para a otimização de programas de controle biológico. Desta forma, o presente trabalho teve por objetivo determinar como a variabilidade genética influencia diferentes parâmetros biológicos de Trichogramma pretiosum Riley, 1879 em experimentos de laboratório e de campo. Para que este objetivo fosse atingido, foram avaliados: 1) o efeito da seleção de isolinhagens de T. pretiosum em condições de laboratório, marcadas por meio do DNA mitocondrial, no su

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Bertolin, Giulia. "Elucidating the functional interplay between Parkinson’s disease-related proteins and the mitochondrion." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T043/document.

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La maladie de Parkinson (MP) est une affection neurodégénérative fréquente d’étiologie inconnue, touchant environ 5% de la population mondiale après 80 ans. Environ 10% des cas correspondent à des formes familiales à transmission mendélienne. Pendant longtemps, un dysfonctionnement mitochondrial a été soupçonné jouer un rôle dans la physiopathologie de la MP. Cette possibilité a été récemment corroborée par des découvertes majeures réalisées dans le cadre des formes autosomiques récessives. Parkine et PINK1, les produits de deux gènes associés à ces formes familiales, participent au sein d’une

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Moreau, Kevin. "Etude génomique des mécanismes nucléaires de contrôle qualité et dégradation de l'ARN." Thesis, Orléans, 2019. http://www.theses.fr/2019ORLE3012.

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La transcription des ARN messagers (ARNm), chez les eucaryotes est un processus complexe nécessitant de nombreuses étapes. En parallèle de ce mécanisme fondamentale, de nombreuses protéines vont se fixer à l’ARNm naissant afin de le maturer et de l’empaqueter pour former une particule ribonucléoprotéique (mRNP) compétente pour l’export vers le cytoplasme, où aura lieu la traduction. Les étapes de biogénèse de cette mRNP sont soumises à la surveillance par un système de contrôle qualité (QC) qui détectera tout évènement conduisant à une mauvaise formation de la particule. Les transcrits aberran

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Tseng, Yi-Hsuan, and 曾逸璿. "3D Mitochondrial Morphological Analysis Reveals Mitochondrial Biogenesis and Quality Control in Cell Cycle." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/68596379529338347252.

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碩士<br>國立陽明大學<br>生物醫學資訊研究所<br>101<br>The function of mitochondria is highly correlated with mitochondrial morphology. Mitochondrial morphology and functions change during cell cycle, and these changes usually imply specific physiological conditions. In the mitotic phase, mitochondria become hyperfused to reach maximal activity. To analyze mitochondrial 3D morphological changes, we established a high content analysis system to apply to normal rat kidney cell image stacks. By using our system, we calculated mitochondrial morphological features to classify mitochondria into 5 different subtypes.

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Kumar, Abhishek. "Understanding the structural organization of the carrier translocase machinery in regulating mitochondrial biogenesis and organelle quality control." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/5036.

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Mitochondria are essential eukaryotic organelles required for diverse cellular functions including, energy homeostasis, iron-sulfur cluster biogenesis, and signaling. Therefore, the maintenance of organelle quality control is critical for cell survival, and any impairment in mitochondrial function is detrimental to cells. Proper mitochondrial functioning requires accurate and efficient transport of approximately 99% of proteins from the cytosol to their precise location into the mitochondria. This protein import is performed by sophisticated protein machinery present at the outer and inner mit

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Levchenko, Mariia. "Mitochondrial protein assemblies: Biogenesis of the cytochrome c oxidase and mitophagic signaling complexes." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0028-8824-B.

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Barbosa, Inês Biscaia de Andrade. "TRAP1 regulation of mitochondrial homeostasis and cellular quality control." Doctoral thesis, 2014. http://hdl.handle.net/10316/24489.

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Tese de doutoramento em Biologia apresentadas à Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>Through years of evolution and in order to maintain viable protein homeostasis, cells have developed defense mechanisms against the accumulation of misfolded proteins and aggregates. This mechanism comprises a complex network of specialized proteins designated as heat shock proteins (HSPs). Tumor necrosis factor receptor (TNFR)-associated protein 1 (TRAP1) is a 90 KDa HSP family member that has received large attention over the past years. The interest in TRAP1 originated from its i

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Drago, Rita Catarina Vaz. "Co-transcriptional quality control of mRNA biogenesis : impact for human genetic diseases." Doctoral thesis, 2018. http://hdl.handle.net/10451/37217.

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Tese de doutoramento, Ciências Biomédicas (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Medicina, 2018<br>Protein coding genes are transcribed in the nucleus by RNA polymerase II (RNAPII) forming a precursor messenger RNA (pre-mRNA) that undergoes extensive processing including 5' capping, splicing, 3' end cleavage and polyadenylation to form a mature mRNA. Pre-mRNA processing takes place cotranscriptionally, potentiated by the carboxyl-terminal domain (CTD) of the largest subunit of RNAPII, in a way that transcription and processing machineries communicate with each oth

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Alessi, Dana. "Mechanisms Underlying Mitochondrial Quality Control and Cytokinesis in Budding Yeast." Thesis, 2014. https://doi.org/10.7916/D8Z60M6X.

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This work discusses both mechanisms underlying mitochondrial quality control and cytokinesis in the budding yeast Saccharomyces cerevisiae. As these topics are quite different, their presentation has been divided into two parts, "Part I: Mitochondrial Remodeling Through the Proteasome is Critical for Mitochondrial Quality Control in Budding Yeast" and "Part II: Aim44p Regulates Phosphorylation of Hof1p to Promote Contractile Ring Closure During Cytokinesis in Budding Yeast." In Part I, we show that the proteasome is critical for cellular fitness in response to chronic, low levels of mitochondr

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Weng, Ching-Wen, and 翁靖雯. "Effect of Acrolein on Mitochondrial Quality Control in Human Lung Cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/79279500624161488712.

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碩士<br>國立陽明大學<br>藥理學研究所<br>104<br>Acrolein, a ubiquitous environmental pollutant, can be found in cigarette smoke, car exhausts, and overheated cooking oils, which are known as risk factors of lung diseases including asthma, chronic obstructive pulmonary disease (COPD) and lung cancer. Our previous studies have been shown that acrolein induces mutagenic DNA adducts and inhibits DNA repair, which plays an important role in lung carcinogenesis. Mitochondrial homoeostasis is crucial through mitochondrial fission/ fusion cycle, biogenesis, and mitophagy, a selective mitochondrial autophagy. It is n

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Kapur, Meghan Danielle. "The Regulation of Lipid Metabolism and Mitochondrial Quality Control in Health and Disease." Diss., 2015. http://hdl.handle.net/10161/9852.

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<p>Advances in modern medicine have helped to prolong human life. These advancements coupled with an ever-increasing population means that diseases associated with aging will become more prevalent in the coming years. As such, it is critical to understand the pathogenesis of disease where aging is the main risk factor. While not widely known, age is in fact a large risk factor in development of obesity and metabolic syndrome. More widely known and discussed are the neurodegenerative diseases that occur late in life. While age as a risk factor is a common point between these types of patho

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Li, Li-Jie, and 李俐潔. "Studies on the mechanism of mitochondrial dynamics and quality control during cell division." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/11254143422348381487.

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碩士<br>國立陽明大學<br>生命科學系暨基因體科學研究所<br>102<br>Mitochondria are dynamic organelles that undergo fusion, fission and mitochondria quality control (mitophagy). Proper mitochondrial dynamics regulates mitochondrial damages to ensure cellular integrity. During cell division, not only genetic materials but also organelles are evenly distributed to daughter cells. Current model for mitochondrial inheritance in mammalian cells suggested that mitochondria undergo complete fission for even partition to daughter cells. Paradoxically, extensive mitochondrial fission may result in too low production of energy t

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de, Vries Rosa Leonora Andrea. "Be Eaten to Stay Healthy: Elucidating the Mechanisms of Mitochondrial Quality Control by Mitophagy." Thesis, 2013. https://doi.org/10.7916/D81R6QJ2.

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Mitochondria are essential organelles that provide the cell with energy and are involved in many housekeeping processes. Maintaining a healthy population of mitochondria is vital for the proper functioning of cells and the presence of dysfunctional mitochondria may lead to cellular damage and cell death. Neurons are particularly susceptible to the consequences of mitochondrial damage as they have high energy needs and are post-mitotic. The clearance of damaged mitochondria by autophagy, or mitophagy, has emerged as an important quality control mechanism. The Parkinson's disease related protein

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TRANI, GIULIA. "Characterization of patients with mitochondrial disease: assessment of the pathological phenotype associated with genes involved in mitochondrial quality control and dynamics." Doctoral thesis, 2020. http://hdl.handle.net/11573/1384909.

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Summary: The maintenance of healthy and functional mitochondria is essential for cellular homeostasis; a first check point is provided by the organelle itself through the mitochondrial quality control and through the mitochondrial dynamics. Mitochondrial dynamics involve the Drp1 protein, a large dynamin-like GTPases encoded by DNM1L gene, that is responsible for fission of mitochondria. Mutations in DNM1L gene have been associated with several neurological disorders (Schmid et al. 2019). Furthermore, one of the main players of the mitochondrial quality control is the Lon protease encoded by

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Brisebois, Francois. "Role of E3-ligase parkin in mitochondrial quality control in a cardiotoxicity model to anthracyclines." Thèse, 2015. http://hdl.handle.net/1866/13809.

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Dues à leur importance croissante dans la dégénérescence musculaire, les mitochondries sont de plus en plus étudiées en relation à diverses myopathies. Leurs mécanismes de contrôle de qualité sont reconnus pour leur rôle important dans la santé mitochondrial. Dans cette étude, nous tentons de déterminer si le déficit de mitophagie chez les souris déficiente du gène Parkin causera une exacerbation des dysfonctions mitochondriales normalement induite par la doxorubicine. Nous avons analysé l’impact de l’ablation de Parkin en réponse à un traitement à la doxorubicine au niveau du fonctionn

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Goswami, Arvind Vittal. "Role of Grp 75 Chaperone Folding Machinery in the Maintenance of Mitochondrial Protien Quality Control." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/3333.

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My research focuses on understanding the importance of human mitochondrial Hsp70 (Grp75) chaperone machinery for the maintenance of protein quality control inside the mitochondrial matrix. The investigations carried out during this study have been addressed towards gaining better insights into the working of Grp75 chaperone folding machinery in association with its diverse set of co-chaperones residing in human mitochondria. Additionally, the research also focuses on explaining the various modes of Grp75 participation leading to multiple disease conditions. The thesis has been divided into the

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Goswami, Arvind Vittal. "Role of Grp 75 Chaperone Folding Machinery in the Maintenance of Mitochondrial Protien Quality Control." Thesis, 2013. http://etd.iisc.ernet.in/2005/3333.

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My research focuses on understanding the importance of human mitochondrial Hsp70 (Grp75) chaperone machinery for the maintenance of protein quality control inside the mitochondrial matrix. The investigations carried out during this study have been addressed towards gaining better insights into the working of Grp75 chaperone folding machinery in association with its diverse set of co-chaperones residing in human mitochondria. Additionally, the research also focuses on explaining the various modes of Grp75 participation leading to multiple disease conditions. The thesis has been divided into the

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Deus, Cláudia Maria Carrudo de. "Metabolic Remodeling and Quality Control Mechanisms in Parkinson's Disease." Doctoral thesis, 2021. http://hdl.handle.net/10316/95433.

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Tese no âmbito do Doutoramento em Biologia Experimental e Biomedicina, ramo de especialização em Neurociências e Doença, apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra.<br>Parkinson’s Disease (PD) is the most common movement disorder and the second most common neurodegenerative disorder, having a prevalence of ~2% in people older than 65 years old. Currently, PD has no cure and no early diagnostic method exists. Considering the increase in average age of population, PD prevalence is predicted to increase in the next years. Pathologically, PD is characteriz

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Withers, Crystal Michele. "NOS2 Induction and HO-1-Mediated Transcriptional Control in Gram-Negative Peritonitis." Diss., 2013. http://hdl.handle.net/10161/8053.

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<p>Nitric oxide (NO) is an endogenous gaseous signaling molecule produced by three NO synthase isoforms (NOS1, 2, 3) and important in host defense. The induction of NOS2 during bacterial sepsis is critical for pathogen clearance but its sustained activation has long been associated with increased mortality secondary to multiple organ dysfunction syndrome (MODS). High levels of NO produced by NOS2 incite intrinsic cellular dysfunction, in part by damaging macromolecules through nitration and/or nitrosylation. These include mitochondrial DNA (mtDNA) and enzymes of key mitochondrial pathways requ

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Aleixo, Inês Sofia Marques. "Chronic exercise mitigates Doxorubicin- induced cardiac and brain mitochindrial liabilities - Role for mitochondrial oxidative stress, apoptotic and quality control signaling." Doctoral thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/76157.

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Aleixo, Inês Sofia Marques. "Chronic exercise mitigates Doxorubicin- induced cardiac and brain mitochindrial liabilities - Role for mitochondrial oxidative stress, apoptotic and quality control signaling." Tese, 2013. https://repositorio-aberto.up.pt/handle/10216/76157.

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Vishwanathan, Vinaya. "Understanding the role of mtHsp70 in regulating mitochondrial homeostasis: revealing its significance in Congenital Sideroblastic Anemia progression." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5971.

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Mitochondria are ubiquitous organelles placed at the nexus of several metabolic and signaling pathways essential for cell survival. Therefore, maintaining a healthy and functional organelle becomes paramount for the cell. The complex structural organization and the bi-genomic nature of the mitochondria pose a significant challenge in maintaining their homeostasis. In addition to the proteins encoded by the mitochondrial DNA (mtDNA), the mito-proteome primarily consists of nuclear-encoded proteins synthesized in the cytosol and subsequently translocated to the mitochondria. Thus, the biogenesis

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