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Dissertations / Theses on the topic 'Mitofusins'

Author: Grafiati

Published: 22 June 2024

Last updated: 31 July 2025

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1

Versini, Raphaëlle. "Structural basis of outer-mitochondrial membrane mitofusin-guided fusion." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS653.pdf.

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Le projet de doctorat porte sur l'étude structurale des mitofusines (Mfn1/2 chez l'homme et Fzo1 chez la levure) en utilisant principalement des méthodes basées sur la modélisation telles que la dynamique moléculaire ou les méthodes de prédiction de structure basées sur l'intelligence artificielle (principalement AlphaFold). Les mitochondries forment un réseau complexe à l'intérieur des cellules, subissant des événements continus de fusion et de fission. Ces processus façonnent la dynamique mitochondriale et sont essentiels pour l'entretien, la fonction, la distribution et l'héritage des mitoc

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2

Sauvanet, Cécile. "Caractérisation des acteurs et des mécanismes de la fusion mitochondriale." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21883/document.

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Les mitochondries sont des organites dynamiques qui fusionnent et se divisent continuellement. Cette dynamique est requise pour la biogenèse mitochondriale, la fonction et la dégradation. Les relations entre les OXPHOS, la dynamique et les mécanismes assurant la modulation de la dynamique restent largement inconnus. Nous avons étudié grâce à un essai de fusion in vivo, les relations entre la fusion et les OxPhos dans des cellules de levure portant des mutations ponctuelles dans le gène mitochondrial ATP6 qui sont associés à des maladies chez l’homme. Nous montrons que les défauts des OxPhos pr

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3

Alsayyah, Cynthia. "Régulation de la fusion mitochondriale par le Système Ubiquitine Protéasome et les contacts physiques mitochondrie - peroxysomes chez la levure Saccharomyces cerevisiae." Electronic Thesis or Diss., Université Paris sciences et lettres, 2021. https://theses.hal.science/tel-03810525.

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Les mitochondries sont des organelles très dynamiques qui subissent des phénomènes de fission et de fusion constants de leurs membranes extérieures et intérieures. Ces processus sont essentiels pour le maintien des fonctions mitochondriales essentielles telles que la phosphorylation oxydative ou la signalisation du calcium. D’un point de vue moléculaire, la fusion et la fission mitochondriale dépendent tous les deux des grandes GTPases de la famille des protéines de type dynamine. Les dynamines qui favorisent l’attachement et la fusion des membranes mitochondriales extérieures sont appelés les

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4

Hamze, Carmen. "Mitofusin 1 and Mitofusin 2 Function in the Context of Brain Development." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20347.

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Mitofusin 1 and 2 are outer-mitochondrial membrane proteins that have been shown to be involved in fusion. Mitofusin 2 has also been associated with apoptosis and development. When Mfn1 and Mfn2 were each conditionally knocked out from the cerebellum, Purkinje cells in Mfn2 deficient cerebellum during development had undergone neurodegeneration. Mutations in Mfn2 have also been associated with the Charcot Marie Tooth Type 2A (CMT2A). We want to asses the effect Mfn2 and Mfn1 might have on the development of other regions of the brain such as the telencephalon. We generated Mfn1 and Mfn2 condit

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5

Daste, Frédéric. "Function and regulation of coiled‐coil domains in intracellular membrane fusion." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T001.

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Les mécanismes moléculaires impliqués dans la fusion membranaire ont été amplement étudiés au cours des trente dernières années. Notre compréhension actuelle de ce phénomène est principalement basée sur des résultats obtenus par (1) le développement de modèles physiques décrivant la fusion des membranes biologiques, (2) l’étude mécanistique et structurale des protéines de fusion membranaire des virus à enveloppe et (3) l’étude des évènements de fusion intracellulaire médiés par les protéines SNARES dans les cellules eucaryotes. La découverte du complexe SNARE fut l’aboutissement de travaux int

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6

Cerqueira, Fernanda Menezes. "Efeitos da restrição calórica nas vias de sinalização por insulina e óxido nítrico: implicações para biogênese, morfologia e função mitocondriais." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-24022013-151501/.

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A restrição calórica (RC) estende a expectativa de vida de muitos organismos por mecanismos ainda em estudo. Entre os vários efeitos fisiológicos da RC encontra-se o aumento na biogênese mitocondrial, dependente de óxido nítrico (NO•), sintetizado pela enzima óxido nítrico sintase endotelial (eNOS). Um dos indutores fisiológicos mais potentes da eNOS é a insulina, cujos níveis plasmáticos são consideravelmente reduzidos nos organismos em RC. O objetivo deste trabalho foi investigar os mecanismos associados ao aumento da sinalização por NO• durante a RC in vivo e in vitro, e as cons

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7

Guillery, Olwenn. "Dynamique mitochondriale : caractérisation moléculaire et fonctionnelle de ses acteurs, de ses besoins énergétiques et de son évolution au cours de la mitose." Paris 6, 2008. http://www.theses.fr/2008PA066313.

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Les mitochondries sont des organites intracellulaires délimités par deux membranes. Remarquablement dynamiques, elles fusionnent et fissionnent en permanence. Au cours de ma thèse je me suis intéressée aux mécanismes de cette dynamique et à sa pertinence physiologique. De nouveaux tests de fusion nous ont permis de montrer que la fusion des membranes mitochondriales interne et externe est effectuée par deux machineries aux besoins énergétiques différents. Nous avons également montré que la protéolyse d’OPA1, facteur de la fusion de la membrane interne, est régulée par le potentiel de membrane

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8

Trevisan, Tatiana. "Ruolo della morfologia e della funzionalità mitocondriale sulla distribuzione intracellulare dei mitocondri in neuroni di Drosophila." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424418.

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ABSTRACT Mitochondria are the energy producing organelles in eukaryotic cells providing ATP through oxidative phosphorylation (OXPHOS). Mitochondria are highly dynamic and undergo fission, fusion and move into the cell along the microtubules to generate the mitochondrial network. Mitochondrial dynamics play a critical role in the control of organelle shape, size, number, function and quality control of mitochondria. It is regulated by several GTPases that play an important role in fusion and fission processes. In mammals, mitochondrial fusion is controlled by Mitofusin 1 (Mfn1), Mitofusin 2 (

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9

Sexton, Jaime. "Genetic Analysis of Miro and Mitofusin Protein Interactions." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/321953.

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10

Gangaraju, Sandhya. "Role of mitofusin2 in the regulation of mitochondrial dynamics." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26483.

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Mitochondria in all cell types undergo frequent fission and fusion events, and these dynamics determine the overall morphology of the organelle in cells. Two important GTPases have been recently identified that regulate mitochondrial membrane activity, a dynamin related protein (DRP1) required for fission, and the novel fusion GTPase, Mitofusin2. Mitofusin2 is an outer mitochondrial membrane protein and, like other GTPases involved in membrane fusion events, the N-terminal GTPase domain is exposed to the cytosol, such that it could interact with and recruit potential cytosolic proteins. The wo

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11

Soriano, Zaragoza Francesc X. (Francesc Xavier). "Regulación transcripcional del gen de Mitofusina 2 en músculo esquelético." Doctoral thesis, Universitat de Barcelona, 2004. http://hdl.handle.net/10803/2994.

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Mitofusina 2 (Mfn2) es una proteína de fusión mitocondrial. Las evidencias experimentales demuestran una menor expresión génica de <i>Mfn2</i> en músculo esquelético de sujetos obesos y pacientes diabéticos de tipo 2. Al inhibir la expresión de Mfn2 en células en cultivo se reduce el consumo de oxígeno, el potencial de membrana mitocondrial y la oxidación de glucosa, indicando un papel relevante de Mfn2 en la biología mitocondrial así como en la fisiopatología de la obesidad y/o la diabetes de tipo 2. Además, se han relacionado mutaciones en el gen de <i>Mfn2</i> con la neuropatía de Charcot-

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12

Segalés, Dalmau Jessica. "Efectes de la proteïna Mitofusina 2 sobre el metabolisme muscular." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/83914.

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Els mitocondris són orgànuls citoplasmàtics que tenen un paper fonamental en múltiples processos biològics com l’oxidació de substrats i la producció d’ATP, la senyalització cel•lular, l’apoptosi, el control del cicle cel•lular i l’homeòstasi del calci. Els mitocondris són orgànuls dinàmics, que pateixen canvis de morfologia regulats per processos de fusió i de fissió. Existeix un equilibri entre ambdós processos que és indispensable per a la correcta funció mitocondrial. Les proteïnes que participen directament en la fusió mitocondrial en mamífers són les mitofusines (Mfn1 i Mfn2), localitzad

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13

Detmer, Scott A. Bjorkman Pamela Jane. "The role of the mitofusin proteins in mitochondrial fusion and disease /." Diss., Pasadena, Calif. : Caltech, 2007. http://resolver.caltech.edu/CaltechETD:etd-04132007-181115.

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14

Papanicolaou, Kyriakos. "Consequences of mitofusin ablation in cardiac myocytes. A genetic study in mice." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12827.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Mitofusin-1 (Mfn-1) and mitofusin-2 (Mfn-2) are membrane-embedded mechanoenzymes involved in the remodelling and merging of the mitochondrial biomembrane. In differentiated cardiac myocytes, mitochondria occupy

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15

Martorell, Riera Alejandro. "Regulación de la dinámica mitocondrial en neuronas sometidas a excitotoxicidad." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/286367.

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Durante el ictus, los niveles elevados de glutamato extracelular, el principal neurotransmisor excitador en el sistema nervioso central, aumentan y se unen al receptor de NMDA promoviendo la excitotoxicidad. Esta situación genera que un flujo excesivo de Ca2+ pase a través del receptor de NMDA aumentando sus concentraciones intracelulares activando toda una serie de cascadas de señalización que pueden actuar directamente sobre las mitocondrias, promoviendo varios programas de muerte celular. Las mitocondrias son orgánulos muy dinámicos que constantemente se fusionan y dividen,

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16

Debattisti, Valentina. "Drosophila Marf is the evolutionary ancestor of mammalian Mfn2: a phylogenetic analysis." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3423326.

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Mitochondria are essential organelles for cellular homeostasis. Their main function is to produce energy: mitochondrial respiration provides most of the ATP required for endoergonic reactions. Furthermore, they regulate levels and transients of cytosolic Ca2+ and are crucially involved in apoptosis, aging and oxidative stress (Dimmer and Scorrano, 2006). As much as 20% of the mitochondrial surface is in close contact with the endoplasmic reticulum (ER). This organization is important for the generation of high Ca2+ microdomains required to activate mitochondrial Ca2+ uptake under certain condi

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17

Chivite, Araiz Íñigo. "Endothelial Mitofusin 2 deficiency improves systemic metabolic health and delays age-associated decline." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/668506.

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Blood vessels distribute nutrients and oxygen to every single cell in the body. Endothelial cells define the vessel wall, and thus they are ideally located to crucially modulate nutrient availability and act as metabolic gatekeepers of the organism. In recent years, mitochondrial dynamics has emerged as a bioenergetic adaptation process to cellular metabolic demands. Mitofusins are GTPase-like proteins implicated in external mitochondrial membrane fusion. Our hypothesis is that mitochondrial fusion in endothelial cells is implicated in energy balance and metabolic control. In order to address

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18

Gall, Jonathan M. "Hexokinase and mitofusin 2: mitochondrial modulators of apoptosis in ischemic acute kidney injury." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12392.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Mitochondrial injury and apoptosis promote organ failure after ischemic acute kidney injury (AKI), a common cause of morbidity and mortality. In these studies, we propose that hexokinase (HK), mitofusin 2 (MF

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19

De, Vecchis Dario. "Gaining insights into mitochondrial membrane fusion through a structural and dynamic atomistic model of the mitofusin Fzo1p." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC001.

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Les mitochondries sont des organites dynamiques dont la morphologie dépend de l’équilibre fusion/fission de leurs membranes. Ce processus essentiel à la survie cellulaire est nommé dynamique mitochondriale et sa dérégulation est associée à des troubles neurologiques. Cependant les mécanismes précis régissant la dynamique mitochondriale ne sont pas élucidés. Cette thèse porte sur la protéine Fzo1p, une grande GTPase de la superfamille des Dynamin-related-Protein. C’est un élément clé impliqué dans la fusion mitochondriale de la membrane externe de la levure. Sa structure et sa dynamique ont été

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McCorquodale, Donald S. III. "Identification of Novel Phospholipid Related Functions of Mitofusin 2 in Cell Models of Charcot-Marie-Tooth Disease 2A." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/580.

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The mitofusin 1 and 2 (MFN and MFN2) proteins reside in the outer mitochondrial membrane and have been shown to regulate mitochondrial network architecture by mediating tethering and fusion of mitochondria. Mitochondria normally form a tubular and branched reticular network dynamically regulated by a balance of fusion and fission events. Absence of either Mfn1 or Mfn2 results in a fragmented mitochondrial network. Züchner et al. previously described mutations in the gene mitofusin 2 (MFN2) as the cause of the major autosomal-dominant, axonal form of Charcot-Marie-Tooth neuropathy (CMT2A). CMT

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21

Khalil, Bilal. "Importance du contrôle qualité des mitochondries dans les maladies neurodégénératives : analyse cellulaire et génétique dans des modèles drosophile de la maladie de Huntington et de la sclérose latérale amyotrophique." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5054.

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Les mitochondries sont la principale source d’énergie dans les neurones. Les défauts mitochondriaux participent à l’apparition de maladies neurodégénératives, cependant ils peuvent être contrés par un système de contrôle qualité. Le but de ma thèse a été de déterminer si ce système est dérégulé dans la maladie de Huntington (MH) et la sclérose latérale amyotrophique (SLA) et si sa restauration est neuroprotectrice, en utilisant principalement des modèles drosophile. La MH, caractérisée par une atteinte des neurones du striatum, est due à la protéine Huntingtin mutée (mHtt). Nous avons montré q

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Capel, Émilie. "Formes monogéniques de lipomatose de Launois-Bensaude : étude clinique et moléculaire, et modélisation cellulaire." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS501.

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Ce travail initié en lien avec le centre de référence des Pathologies Rares de la Résistance à l’Insuline et de l’Insulino-Sensibilité, s’intéresse à l’étude de la physiopathologie de formes rares de syndromes lipodystrophiques. Parmi ceux-ci, la lipomatose de Launois-Bensaude (LLB) est caractérisée par la présence de masses lipomateuses associées à des troubles métaboliques. Nous avons investigué la plus grande cohorte de patients atteints de LLB due au variant p.Arg707Trp du gène MFN2, codant la mitofusine 2, une protéine de la fusion mitochondriale. Nous avons également étudié une patiente

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Legros, Frédéric. "Étude de la dynamique du compartiment mitochondrial et des mutations hétéroplasmiques de l'ADN mitochondrial." Paris 7, 2002. http://www.theses.fr/2002PA077109.

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Thaher, Osamah Mahmud Ali Yosif Hamdan [Verfasser]. "Adaption der mitochondrialen Form und Funktion an oxidativen Stress durch Mitofusin-2 / Osamah Mahmud Ali Yosif Hamdan Thaher." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2021. http://d-nb.info/1237814839/34.

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Harland, Micah Thomas. "Neuronal Mitofusin 2 Modulates Neuroinflammation in Acute Systemic Inflammation and Alleviates Pathologies in a Mouse Model for Neurodegenerative Diseases." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586468876190716.

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Dekeyser, Christian [Verfasser], and Christoph [Akademischer Betreuer] Maack. "Die Auswirkungen spezifischer Mitofusin-2-Mutationen auf die mitochondriale Energetik und die Entwicklung von Herzinsuffizienz / Christian Dekeyser ; Betreuer: Christoph Maack." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1205735348/34.

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Bergamin, Giorgia. "Pathogenetic role of MFN2 gene: genetic analysis in patients with charcot-marie-tooth neuropathy and disease modeling in zebrafish." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3422031.

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Charcot-Marie-Tooth diseases (CMTs) are the most common hereditary pathologies of the peripheral nervous system. The dominant subtype CMT2A, one of the most frequent, is caused by mutations in MFN2 gene, coding for mitofusin 2, a dynamin-like GTPase located in the outer membrane of mitochondria. MFN2 is involved in several cellular processes, as the fusion of mitochondrial membranes, the transport of mitochondria along axons and the tethering of mitochondria with endoplasmic reticulum. To date more than 80 mutations associated with CMT2A and complicated variants of CMT2 have been described. Th

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Morales, Campos Pablo Esteban. "Efectos de la incretina glp-1 sobre el acoplamiento retículo endoplásmico-mitocondria en células de músculo liso vascular : rol de pka y mitofusina-2." Tesis, Universidad de Chile, 2012. http://www.repositorio.uchile.cl/handle/2250/113560.

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Magíster en Bioquímica, área de especialización Bioquímica de Proteínas Recombinantes<br>Memoria de Título de Bioquímico<br>La hormona GLP-1 es una reguladora importante de la homeostasis de la glucosa, favoreciendo su metabolismo en varios tejidos a través de la activación de la vía del AMP cíclico-proteína kinasa A. En las células de músculo liso vascular (VSMC), el control del metabolismo de la glucosa es esencial para la mantención de la función y el fenotipo celular, ya que al favorecer su oxidación en las mitocondrias, se previene la aparición de un fenotipo desdiferenciado, característi

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Mages, Christine Maria Gabriele [Verfasser], Christoph [Gutachter] Maack, Kristina [Gutachter] Lorenz, and Alma [Gutachter] Zernecke-Madsen. "Effekt von Mitofusin 2 Defizienz auf die IP_3-induzierte mitochondriale Calciumregulation in Kardiomyozyten / Christine Maria Gabriele Mages ; Gutachter: Christoph Maack, Kristina Lorenz, Alma Zernecke-Madsen." Würzburg : Universität Würzburg, 2021. http://d-nb.info/1234391538/34.

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Meiser, Maxie Gesine [Verfasser], and Christoph [Akademischer Betreuer] Maack. "Die Rolle von Mitofusin 2 für die Calcium-Transmission zwischen dem sarkoplastischen Retikulum und Mitochondrien sowie die bioenergetische Adaption in Kardiomyozyten / Maxie Gesine Meiser ; Betreuer: Christoph Maack." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1117028143/34.

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El, Fissi Najla. "Caractérisation d'allèles de mitofusine associés à la maladie de Charcot-Marie-Tooth : mise en évidence de l'implication d'un déséquilibre entre fusion et fission mitochondriale dans le dysfonctionnement des neurones." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0250/document.

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Les mitochondries forment un réseau très dynamique remodelé par deux processus antagonistes appelés : fusion et fission mitochondriales. Chez l’homme, une altération de ces processus, sont à l’origine de nombreuses maladies qui affectent essentiellement le système nerveux. L'objectif principal des travaux de ma thèse était de caractériser l'impact d'un déséquilibre entre la fusion et la fission mitochondriale dans le contexte d'une neuropathie héréditaire : la maladie de Charcot-Marie-Tooth de type 2A (CMT2A), qui est causée par des mutations dominantes dans la mitofusine MFN2. Dans le but d’é

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Sood, Aditi. "Wiring the adaptive response of mitochondria to metabolic transitions : a Mitofusin-2- dependent proteolytic elimination of OPA1 accompanies cristae and mitochondria-ER contacts remodelling in the postprandial mouse liver." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/25772.

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Il est bien accepté dans des modèles en culture que les dynamiques mitochondriales et le remodelage des crêtes régulent le fonctionnement mitochondrial sous diverses conditions de stress, particulièrement l’apoptose et la famine. Malgré la quantité impressionnante de recherche effectuée dans ce domaine, on en connait encore très peu au sujet de l’importance des dynamiques mitochondriales et du remodelage de la structure mitochondriale sous des conditions physiologiques. Dans les années 1960, Hackenbrock a démontré que des mitochondries isolées adoptent des conformations internes distinctes sel

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Basso, Valentina. "Regulation of ER-Mitochondria tethering in an in vivo animal model of Parkinson's disease." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425287.

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Mitochondria form a tubular, reticulated network which shape is controlled by opposing fusion and fission events (Bereiter-Hahn and Voth, 1994). The mitofusins 1 and 2 (Mfn1 and Mfn2) are conserved, dynamin-like GTPases embedded in the outer mitochondrial membrane (OMM) that mediate mitochondrial fusion in coordination with OPA1 (Rojo et al., 2002; Santel and Fuller, 2001; Wong et al., 2000). Mitochondrial shaping proteins have pleiotropic functions. In particular, while Mfn1 seems primarily involved in organellar docking and fusion, Mfn2 is enriched at contact sites between ER and mitochondri

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Lin, Mei-Yao, and 林美瑤. "Expression of Mitofusins in non-small cell lung cancer." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/54626194590054301664.

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碩士<br>國立中興大學<br>生物醫學研究所<br>93<br>The accumulated evidences show that the dynamic behaviors (fission and fusion) of mitochondria are crucial for many cellular functions. Mitochondrial fusion serves to mix and to unify the mitochondrial compartment, which are important in cellular aging, development, energy dissipation and mitochondrial DNA inheritance. Mitofusins, proteins that are expressed on mitochondrial outer membrane, have been identified as key components of mitochondrial fusion machinery in mammalian cells. Moreover, these proteins were shown to mediate cell growth and development. Howe

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Detmer, Scott A. "The Role of Mitofusin Proteins in Mitochondrial Fusion and Disease." Thesis, 2007. https://thesis.library.caltech.edu/1376/1/detmer_thesis.pdf.

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We have investigated the role of mitofusin proteins in mitochondrial fusion and Charcot-Marie-Tooth disease Type 2A (CMT2A). Mitofusins (Mfn1 and Mfn2) are required for mammalian mitochondrial fusion. In structure-function analysis, we have identified loss-of-function mutations in mitofusin GTPase and heptad-repeat domains that disrupt homotypic and heterotypic domain interactions. Mutations in Mfn2 cause CMT2A, a progressive peripheral neuropathy. We have functionally characterized Mfn2 disease mutations and find that wild-type Mfn1, but not Mfn2, can efficiently complement nonfunctional

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Vemula, Pradheep. "Manipulation of Mitofusin2/Ras interaction as a therapy for acute ischemic kidney injury." Thesis, 2014. https://hdl.handle.net/2144/15346.

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Mitofusin 2 (MFN2), an outer mitochondrial membrane protein expressed in virtually all human tissues, is a multi-faceted protein known to affect mitochondrial morphology, metabolism, tethering, and movement as well as overall cell cycle progression. Most intriguing among its characteristics is its ability to bind to Ras and Raf, upstream effectors in the MAPK/ERK pathway. Conditional knockout (cKO) of renal proximal tubule MFN2 in vivo showed a post-ischemic protective effect. While the two day survival of control mice was only 28%, an unexpected 86% of the MFN2 cKO mice were alive at two day

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Mages, Christine Maria Gabriele. "Effekt von Mitofusin 2 Defizienz auf die IP\(_3\)-induzierte mitochondriale Calciumregulation in Kardiomyozyten." Doctoral thesis, 2021. https://doi.org/10.25972/OPUS-23796.

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Das Herz ist physiologisch auf einen fein regulierten und ausgeglichenen bioenergetischen Energiehaushalt angewiesen, um auf akute Belastungssituationen adäquat reagieren zu können und oxidativen Stress zu vermeiden. Ca2+ reguliert zentral sowohl die zyklischen Kontraktions-/Relaxationsprozesse (ECC) als auch unmittelbar den mitochondrialen Metabolismus. Der ECC liegt in den Kardiomyozyten die Ca2+- Freisetzung durch die RyR2 zu Grunde; die IP3 Rezeptoren des sarkoplasmatischen Retikulums (SR) führen davon unabhängig zu einer Ca2+ Freisetzung aus dem SR. Diese IP3R vermittelten Signale werden

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Liao, Hung-Chen, and 廖紅禎. "Expression of mitofusion-2 in non-small cell lung cancer." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/99962672208367871017.

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碩士<br>國立中興大學<br>生命科學院碩士在職專班<br>98<br>Mitochondria are key players in several cellular functions including growth, division,energy metabolism, and apoptosis. Mitochondrial dysfunction contributes to a number of human disorders and may aid cancer progression. Although normal mitochondrial morphology is important for the function and physiology of cells, defects in mitochondrial dynamics may cause severe diseases. Fusion and fission of mitochondria regulate their morphology and distribution. Mitofusin-2（Mfn-2）is an outer mitochondrial membrane protein. Recent observations indicate that Mfn2 is

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Miller, Nathanael A. "Mitochondrial dynamics: regulation of insulin secretion and novel quantification methods." Thesis, 2018. https://hdl.handle.net/2144/29974.

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The recent surge in Type 2 Diabetes (T2D) has renewed interest in the study of cellular metabolism – which mitochondria tightly control. Previous work has shown mitochondrial dysfunction plays a critical role in the development of metabolic diseases, such as T2D. The pancreatic β-cell synthesizes and secretes insulin in vivo in response to diverse fuel signals such as glucose, fatty acids, and amino acids; failure or loss of β-cell mass is a hallmark of T2D. Pancreatic β-cell mitochondria are dynamic organelles living a life of fusion, fission, and movement collectively called mitochondrial dy

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Lin, Liang-Yi, and 林良憶. "Non-Autonomous Regulation of Mitochondrial Stress Response and Morphology by Neuronal fzo-1/Mitofusin in C.elegans." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/38532672578567087601.

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碩士<br>國立臺灣大學<br>分子醫學研究所<br>105<br>Tissue-specific stress responses are protective mechanisms against proteotoxic stress and could be regulated in a non-autonomous fashion. Inhibition of mitochondrial respiration or proteostasis triggers systemic mitochondrial unfolded protein response (UPRmt), and recently serotonin and the FLP-2 neuropeptide had been shown to be important for this regulation. Here we report that disrupting mitochondrial dynamics in the neurons, by silencing the mitochondrial fusion gene fzo-1, induced UPRmt and mitochondrial fragmentation in the intestine. Acetylcholine, tyra

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(5930501), Wenqing Zhou. "REGULATION OF NEUTROPHIL MIGRATION TO INFLAMMATION." Thesis, 2019.

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Neutrophils, contributing to approximately 40%-70% of white blood cells in mammals, are the most abundant type of leukocytes in human circulation. As critical effector cells in innate immunity, neutrophils form the first line of host defense against microbes and are the first immune cells recruited to an inflamed tissue. The pathogen phagocytosis, release of reactive chemicals and proteases, and formation of extracellular traps are the key weapons of neutrophils in host defense. However, neutrophils also contribute to collateral tissue damage when performing their antimicrobial functions. The

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Simão, André Daniel Lopes. "Role of mitochondria-targeting miRNAs in non-alcoholic fatty liver disease." Doctoral thesis, 2019. http://hdl.handle.net/10451/42214.

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Non-alcoholic fatty liver disease (NAFLD) comprises a range of liver lesions from simple steatosis to non-alcoholic steatohepatitis (NASH) and remains a major cause of mortality when progressing to cirrhosis and hepatocellular carcinoma (HCC). Although major risk factors relate with the metabolic syndrome, including cross-talk between the liver and the skeletal muscle, the biological mechanisms of disease are not entirely known. Therefore, a better understanding of NAFLD pathogenesis may help in finding novel targeted therapies for patients with liver damage. In that regard, we have shown that

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