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Dissertations / Theses on the topic 'Mitogen activated protein kinase'

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Published: 4 June 2021
Last updated: 6 September 2023

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1

Rojnuckarin, Ponlapat. "Mitogen-activated protein kinase pathways in megakaryocyte development /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9200.

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2

Streicher, John Michael. "The role of mitogen activated protein kinase activated protein kinase-2 in regulating p38 mitogen activated protein kinase induced cyclooxygenase-2 induction and heart failure." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872200951&sid=6&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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3

Davies, Gareth. "Folding of p38 mitogen-activated protein kinase." Thesis, University of Warwick, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412847.

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4

Waskiewicz, Andrew Jan. "Mitogen-activated protein kinase : evolutionary conservation and activation of downstream kinases /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/9216.

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5

Zeng, Qingning. "Dissecting mitogen-activated protein kinase cascades involving arabidopsis MKK6." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/31941.

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Mitogen-activated protein (MAP) kinase cascades act as critical components in the signalling pathways of all eukaryotic cells. They play a pivotal role in the transduction of extra- and intra-cellular stimuli and regulate cell growth, proliferation, differentiation and cell death, through sequential activation of MAP kinase kinase kinases (MAPKKKs), MAP kinase kinases (MKKs), and MAP kinases (MPKs). These three components form modules that control the phosphorylation of various substrates including transcription factors, enzymes, and cytoskeleton-associated proteins. In the Arabidopsis genome,
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6

Cheng, Kwan-wai. "Regulation of equilibrative nucleoside transporter-1 by protein kinase C and mitogen-activating protein kinase /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31494912.

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7

Kerkelä, R. (Risto). "Signaling pathways in myocyte hypertrophy:role of GATA4, mitogen-activated protein kinases and protein kinase C." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514269950.

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Abstract Cardiac myocytes react to increased workload and hypertrophic neurohumoral stimuli by increasing protein synthesis, reinitiating expression of fetal forms of structural genes, α-skeletal actin (α-SkA) and β-myosin heavy chain (β-MHC), and by increasing expression and secretion of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP). Initially, the response is beneficial, but when prolonged, it leads to pathological cardiomyocyte hypertrophy. In this study, cardiomyocyte hypertrophy was initiated by hypertrophic agonists, endothelin-1 (ET-1) and phenylephrine (PE), and
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8

Cheng, Kwan-wai, and 鄭軍偉. "Regulation of equilibrative nucleoside transporter-1 by protein kinaseC and mitogen-activating protein kinase." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45009983.

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9

Maitra, Sushmit. "The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase activated protein kinase 2." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008r/maitra.pdf.

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10

Harrouk, Wafa. "Mitogen-activated protein kinase during oocyte growth in the mouse." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55499.

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In this study, the role of MAP kinase in the acquisition of meiotic competence in growing oocytes was investigated. The results presented in this thesis show that two species of MAP kinase, p42 and p44, are present in their unphosphorylated forms in oocytes as early as 5 days of age. At this age, oocytes are small and have not acquired the capacity to resume meiosis. They are referred to as meiotically incompetent. MAP kinase continues to be present throughout the growth phase and up to the acquisition of meiotic competence.<br>In growing mouse oocytes, a group of partially competent oocytes a
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11

Sakurai, Kenji. "Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis." Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/245835.

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京都大学<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第22150号<br>医博第4541号<br>新制||医||1039(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 竹内 理, 教授 稲垣 暢也, 教授 杉田 昌彦<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM
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12

Brancho, Deborah Marie. "Regulation and Function of Stress-Activated Protein Kinase Signal Transduction Pathways: A Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/101.

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The c-Jun NH2-terminal kinase (JNK) group and the p38 group of mitogen-activated protein kinases (MAPK) are stress-activated protein kinases that regulate cell proliferation, differentiation, development, and apoptosis. These protein kinases are involved in a signal transduction cascade that includes a MAP kinase (MAPK), a MAP kinase kinase (MAP2K), and a MAP kinase kinase kinase (MAP3K). MAPK are phosphorylated and activated by the MAP2K, which are phosphorylated and activated by various MAP3K. The work presented in this dissertation focuses on understanding the regulation and function of the
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13

Weng, Yu-I. "Acute and chronic ethanol effects on liver p42/44 mitogen activated protein kinase." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3036867.

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14

Sloss, Callum. "Control of subcellular distribution of the MAP kinase phosphatase, MKP-2." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288715.

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15

Kawamoto, Takahiro. "Endothelin-1 activates Homer 1a expression via mitogen-activated protein kinase in cardiac myocytes." Kyoto University, 2006. http://hdl.handle.net/2433/135882.

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16

Burt, Andrew Robert. "Regulation of p42/44 mitogen-activated protein kinase by G-protein coupled receptors." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360176.

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17

Walia, Ankit. "Involvement of mitogen-activated protein kinase signalling in plant microtubule function." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/21739.

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Plants have developed sophisticated signalling networks that are involved in mediating developmental transitions and environmental signals. Mitogen-activated protein kinases (MPKs) are a class of signalling proteins that are involved in cellular processes that help plants to detect and initiate appropriate responses to numerous development and environmental inputs. The microtubule cytoskeleton plays a pivotal role in plant development and morphogenesis, although the mechanisms that regulate the microtubule-associated proteins and microtubule functions in plant cells are not well understood. I
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18

Hobbs, Robin Mark. "A role for mitogen-activated protein kinase inepidermal hyperproliferation in inflammation." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399536.

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19

Sarafraz, Shekary Negin. "Contribution of p38 mitogen-activated protein kinase isotypes to cardiac physiology." Thesis, King's College London (University of London), 2010. http://kclpure.kcl.ac.uk/portal/en/theses/contribution-of-p38-mitogen-activated-protein-kinase-isotypes-to-cardiac-physiology(9976a51e-2703-4ead-8746-a1bbc3a56326).html.

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The isoform-specific functions of the four isoforms of p38 mitogen-activated protein kinase (p38 α-, β-, γ- and δ- MAPK) in the adult heart are largely unknown, partly due to the lack of isotype-specific tools to manipulate or measure p38 MAPK isoform activity. Improved understanding of p38 MAPK isoform regulation will benefit development of selective pharmacological inhibitors and move towards eliminating the potential drawbacks of chronic systematic inhibition of this important kinase. This Thesis describes our investigation of endogenous expression of p38 MAPK in the murine heart; the funct
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20

Papakrivopoulou, Eugenia Spyridoula. "The role of MAP kinases in the regulation of mechanical load induced procollagen gene expression in cardiac fibroblasts." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251816.

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21

Mills, Julia. "Regulation of amyloid precursor protein catabolism in vitro, the role of mitogen-activated protein kinase and protein kinase C." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq27201.pdf.

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22

Haines, Jeffery. "Regulation of oligodendrocyte differentiation and myelination by p38 mitogen-activated protein kinase." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95127.

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Oligodendrocytes (OLG) in the central nervous system (CNS) extend multiple processes to ensheath nerve axons with the spiral wrapped membrane known as myelin. The signal transduction pathways that regulate OLG differentiation and CNS myelination are only beginning to be elucidated. We hypothesized that p38 mitogen-activated protein kinase could regulate OLG differentiation, since this kinase has been found to regulate the growth of peripheral nervous system myelinating Schwann cells. Using cultured oligodendrocyte progenitors, we found that treatment with PD169316, a selective p38 MAPK inhi
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23

Davies, Elizabeth Louise. "The role of mitogen-activated protein kinase phosphatase-1 in cardiac hypertrophy." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391714.

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24

Kodituwakku, Jayanie Subhashi. "Mechanisms regulating mitogen-activated protein kinase phosphatase-2 expression in cardiac myocytes." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429111.

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25

Tchen, Rose Carmen. "Regulation of tristetraprolin expression by the mitogen-activated protein kinase p38 pathway." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417449.

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26

Ridley, Simon Hugh. "The role of p38 mitogen-activated protein kinase in interleukin-1 action." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625016.

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27

Engineer, Neelam. "The role of mitogen activated protein kinase in stretch induced preterm labour." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503840.

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28

Haase, Ingo. "Signalling via integrins and mitogen activated protein kinase in human epidermal keratinocytes." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251692.

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29

Wancket, Lyn Miller. "Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385390100.

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30

Han, Ling Zhang Shuqun. "Regulation of ethylene biosynthesis by mitogen-activated protein kinase cascades in Arabidopsis." Diss., Columbia, Mo. : University of Missouri--Columbia, 2008. http://hdl.handle.net/10355/6293.

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Title from PDF of title page (University of Missouri--Columbia, viewed on Feb. 12, 2008). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dr. Shuqun Zhang, Thesis Supervisor. Vita. Includes bibliographical references.
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31

Randall, Susan. "Interactions among the mitogen-activated protein kinase cascades and the identification of a novel cdc2-related protein kinase." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29271.pdf.

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32

Ing, Y. Lynn. "MLK-3, identification and characterization of a protein kinase involved in mitogen-activated protein kinase signal transduction pathways." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0020/NQ45812.pdf.

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33

Lee, Ka Man. "The structural and functional roles of cysteine residues in human mitogen-activated protein kinase kinase six (MKK6) /." View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BICH%202004%20LEE.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2004.<br>Includes bibliographical references (leaves 52-58). Also available in electronic version. Access restricted to campus users.
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34

Samuels, Ivy S. "The roles of ERK₁ and ERK₂ MAP kinase in neural development and disease." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1214495630.

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35

Kim, Jin Ah. "Le rôle du MAPK (Mitogen-Activated Protein Kinase) et CDKs dans la phase G2/M." Université Joseph Fourier (Grenoble), 2008. http://www.theses.fr/2008GRE10172.

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Les points de contrôle du cycle cellulaire assurent la stabilité du génome en retardant la progression du cycle en réponse à des stress ou des dommages causés sur l'ADN. Le point de contrôle de la phase G2 régule l'entrée des cellules en mitose, tandis que le point de contrôle de la formation des fuseaux mitotiques prévient l'entrée en anaphase, jusqu'à ce que les chromosomes soient correctement alignés. Au cours de ma thèse, je me suis intéressée à l'étude des Rôle de MAPKs (Mitogen-Activated Protein Kinases) et de la protéine P21 qui est un inhibiteur de cdk (cyclin dependent kinase), dans l
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36

Salmon, Ruth A. "The role of the p38 mitogen-activated protein kinase in the immune response." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0024/NQ38971.pdf.

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37

Ho, Jenny Mei-Yen. "The activation of mitogen-activated protein kinase pathways by the TEL-JAK2 oncoprotein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/MQ54090.pdf.

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38

Widegren, Ulrika. "Exercise effects on the mitogen-activated protein (MAP) kinase cascade in skeletal muscle /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4319-2/.

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39

Sully, Gareth Brian. "Role of p38 mitogen-activated protein kinase in the regulation of nRNA stability." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270976.

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40

Ma, Yam-man Richard, and 馬蔭民. "The mitogen-activated protein kinase pathway regulates the subcellularlocalization and function of FOXM1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29305378.

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41

Rahman, Nor Zaihana Abdul. "Investigating the role of mitogen activated protein kinase phosphatase-2 on CNS function." Thesis, University of Strathclyde, 2015. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=24835.

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Mitogen-activated protein kinase phosphatases (MKPs) belong to the dual-specificity phosphatase (DUSP) family and are negative regulators of mitogen-activated protein kinases (MAPKs). Recently, MKP-2 has been shown to play a novel role in development, the immune system and cancer. However, our knowledge in relation to its function in the central nervous system (CNS) is limited. Hence, we have utilised novel MKP-2 knockout mice to investigate the role of this phosphatase in CNS function. The effect of MKP-2 deletion on CNS was first investigated using primary hippocampal culture by examining as
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42

Jin, Jiawei. "Signalling regulation of cardiac hypertrophy by the mitogen activated protein kinase (MAPK) pathways." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/signalling-regulation-of-cardiac-hypertrophy-by-the-mitogen-activated-protein-kinase-mapk-pathways(028e5785-b25f-4459-9668-ad13a2885a40).html.

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Heart failure induced by cardiac hypertrophy is a cause of high mortality in the world and has been the fastest growing cardiovascular disease over the past decade. Cardiac hypertrophy is characterised as a reactive increase in cardiac mass growth with a complex of ventricular remodelling. It occurs initially as a compensatory response to an increased workload but eventually leads to cardiac dysfunction. An in-depth understanding of cardiac hypertrophy and the capacity to regulate it has profound clinical implications. The MAPK pathways provide an important connection between external stimuli
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43

Ohashi, Naohiro. "Role of p38 Mitogen-Activated Protein Kinase in Neointimal Hyperplasia After Vascular Injury." Kyoto University, 2001. http://hdl.handle.net/2433/150561.

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44

Lee, Jin Suk. "Role of phosphatases in controlling arabidopsis mapk signalling cascades." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/732.

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Plants possess integrated signalling networks that mediate the responses to various environmental conditions. Mitogen-activated protein kinases (MAPKs) constitute a highly conserved family of enzymes in eukaryotes, and in plants MAPK-based signal transduction modules regulate a large number of physiological processes, including responses to environmental stresses and phytohormones. Regulated dephosphorylation of active MAPKs is a key component of the control of MAPK signalling cascades, and in mammals, members of the MAPK phosphatase (MKP) sub-class of dual-specificity tyrosine phosphatases ha
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45

Cayla, Mathieu. "Caractérisation fonctionnelle de la MAP kinase MPK10 de Leishmania." Paris 7, 2014. http://www.theses.fr/2014PA077252.

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Les protozoaires pathogènes du genre Leishmania ont développé des mécanismes uniques de signalisation leur permettant de détecter des changements dans leur environnement. Ces changements vont permettre leur différenciation, étape essentielle pour assurer leur survie et leur croissance dans la cellule de l'hôte mammifère. Peu de choses sont connues sur les mécanismes mis en jeu lors de la différenciation, mis à part le rôle essentiel joué par les MAP kinases (MAPKs) et la phosphorylation des protéines. Mes travaux de thèse ont permis i) de mettre en évidence les mécanismes de régulation de MPK1
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46

Hannke-Lohmann, Almut. "Veränderung des Mitogen-activated-protein-kinase-Signaltransduktionsweges in der Plazenta von Patientinnen mit Präeklampsie." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=962075825.

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47

Tang, Jing Yan. "Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway." Thesis, University of Macau, 2009. http://umaclib3.umac.mo/record=b2158133.

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48

Brook, Matthew. "Regulation of tumour necrosis factor α gene expression by p38 mitogen-activated protein kinase." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433907.

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49

Kojima, Kaihei. "Studies on the mitogen-activated protein kinase cascades in the phytopathogenic fungus Colletotrichum lagenarium." Kyoto University, 2003. http://hdl.handle.net/2433/148325.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第10505号<br>農博第1378号<br>新制||農||882(附属図書館)<br>学位論文||H15||N3860(農学部図書室)<br>UT51-2003-U475<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授 奥野 哲郎, 教授 遠藤 隆, 教授 植田 和光<br>学位規則第4条第1項該当
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50

Da, Silva Xavier Gabriela. "Glucose-regulated gene transcription in pancreatic islet #beta#-cells." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340080.

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