Relevant bibliographies by topics / Mitotic spindle checkpoint

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Mitotic spindle checkpoint'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Mitotic spindle checkpoint"

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Encalada, Sandra E., John Willis, Rebecca Lyczak, and Bruce Bowerman. "A Spindle Checkpoint Functions during Mitosis in the Early Caenorhabditis elegans Embryo." Molecular Biology of the Cell 16, no. 3 (2005): 1056–70. http://dx.doi.org/10.1091/mbc.e04-08-0712.

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During mitosis, chromosome segregation is regulated by a spindle checkpoint mechanism. This checkpoint delays anaphase until all kinetochores are captured by microtubules from both spindle poles, chromosomes congress to the metaphase plate, and the tension between kinetochores and their attached microtubules is properly sensed. Although the spindle checkpoint can be activated in many different cell types, the role of this regulatory mechanism in rapidly dividing embryonic animal cells has remained controversial. Here, using time-lapse imaging of live embryonic cells, we show that chemical or m
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Rahmani, Zohra, Mary E. Gagou, Christophe Lefebvre, Doruk Emre, and Roger E. Karess. "Separating the spindle, checkpoint, and timer functions of BubR1." Journal of Cell Biology 187, no. 5 (2009): 597–605. http://dx.doi.org/10.1083/jcb.200905026.

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BubR1 performs several roles during mitosis, affecting the spindle assembly checkpoint (SAC), mitotic timing, and spindle function, but the interdependence of these functions is unclear. We have analyzed in Drosophila melanogaster the mitotic phenotypes of kinase-dead (KD) BubR1 and BubR1 lacking the N-terminal KEN box. bubR1-KD individuals have a robust SAC but abnormal spindles with thin kinetochore fibers, suggesting that the kinase activity modulates microtubule capture and/or dynamics but is relatively dispensable for SAC function. In contrast, bubR1-KEN flies have normal spindles but no
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Akhter, Shamima, Christopher T. Richie, Jian Min Deng, et al. "Deficiency in SNM1 Abolishes an Early Mitotic Checkpoint Induced by Spindle Stress." Molecular and Cellular Biology 24, no. 23 (2004): 10448–55. http://dx.doi.org/10.1128/mcb.24.23.10448-10455.2004.

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ABSTRACT Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we show that mammalian SNM1 functions in an early mitotic stress checkpoint that is distinct from the well-characterized spindle checkpoint that regulates the metaphase-to-anaphase transition. Specifically, we found that compared to wild-type cells, Snm1-deficient mouse embryonic fibroblasts exposed to spindle poisons exhibited elevated levels of micronucleus formation, decreased mitotic delay,
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Gorbsky, Gary J. "The mitotic spindle checkpoint." Current Biology 11, no. 24 (2001): R1001—R1004. http://dx.doi.org/10.1016/s0960-9822(01)00609-1.

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Fraschini, Roberta, Denis Bilotta, Giovanna Lucchini, and Simonetta Piatti. "Functional Characterization of Dma1 and Dma2, the Budding Yeast Homologues of Schizosaccharomyces pombe Dma1 and Human Chfr." Molecular Biology of the Cell 15, no. 8 (2004): 3796–810. http://dx.doi.org/10.1091/mbc.e04-02-0094.

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Proper transmission of genetic information requires correct assembly and positioning of the mitotic spindle, responsible for driving each set of sister chromatids to the two daughter cells, followed by cytokinesis. In case of altered spindle orientation, the spindle position checkpoint inhibits Tem1-dependent activation of the mitotic exit network (MEN), thus delaying mitotic exit and cytokinesis until errors are corrected. We report a functional analysis of two previously uncharacterized budding yeast proteins, Dma1 and Dma2, 58% identical to each other and homologous to human Chfr and Schizo
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Gadea, Bedrick B., and Joan V. Ruderman. "Aurora Kinase Inhibitor ZM447439 Blocks Chromosome-induced Spindle Assembly, the Completion of Chromosome Condensation, and the Establishment of the Spindle Integrity Checkpoint inXenopusEgg Extracts." Molecular Biology of the Cell 16, no. 3 (2005): 1305–18. http://dx.doi.org/10.1091/mbc.e04-10-0891.

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The Aurora family kinases contribute to accurate progression through several mitotic events. ZM447439 (“ZM”), the first Aurora family kinase inhibitor to be developed and characterized, was previously found to interfere with the mitotic spindle integrity checkpoint and chromosome segregation. Here, we have used extracts of Xenopus eggs, which normally proceed through the early embryonic cell cycles in the absence of functional checkpoints, to distinguish between ZM's effects on the basic cell cycle machinery and its effects on checkpoints. ZM clearly had no effect on either the kinetics or amp
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Farr, Katie A., and M. Andrew Hoyt. "Bub1p Kinase Activates the Saccharomyces cerevisiae Spindle Assembly Checkpoint." Molecular and Cellular Biology 18, no. 5 (1998): 2738–47. http://dx.doi.org/10.1128/mcb.18.5.2738.

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ABSTRACT Saccharomyces cerevisiae BUB1 encodes a protein kinase required for spindle assembly checkpoint function. In the presence of spindle damage, BUB1 is required to prevent cell cycle progression into anaphase. We have identified a dominantly actingBUB1 allele that appears to activate the spindle assembly checkpoint pathway in cells with undamaged spindles. High-level expression of BUB1-5 did not cause detectable spindle damage, yet it delayed yeast cells in mitosis at a stage following bipolar spindle assembly but prior to anaphase spindle elongation. Delayed cells possessed a G2 DNA con
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Rohrabaugh, Sara, Charlie Mantel, and Hal E. Broxmeyer. "Mouse Hematopoietic Stem Cells, Unlike Human and Mouse Embryonic Stem Cells, Exhibit Checkpoint-Apoptosis Coupling." Blood 110, no. 11 (2007): 3357. http://dx.doi.org/10.1182/blood.v110.11.3357.3357.

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Abstract Cell cycle checkpoints guarantee that cells move through the events of the cell cycle in the appropriate manner. The mitotic spindle checkpoint, also known as the spindle assembly checkpoint (SAC), helps to ensure the proper segregation of chromosomes into daughter cells during mitosis. Our lab recently reported on the condition of the SAC in both mouse and human embryonic stem cells (ESCs). We found that ESCs do not initiate apoptosis when the SAC is activated, which allowed these cells to tolerate a polyploid state resulting from the aberrant mitosis (Mantel et al. Blood.109: 4518–4
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Kapoor, Tarun M., Thomas U. Mayer, Margaret L. Coughlin, and Timothy J. Mitchison. "Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5." Journal of Cell Biology 150, no. 5 (2000): 975–88. http://dx.doi.org/10.1083/jcb.150.5.975.

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Monastrol, a cell-permeable small molecule inhibitor of the mitotic kinesin, Eg5, arrests cells in mitosis with monoastral spindles. Here, we use monastrol to probe mitotic mechanisms. We find that monastrol does not inhibit progression through S and G2 phases of the cell cycle or centrosome duplication. The mitotic arrest due to monastrol is also rapidly reversible. Chromosomes in monastrol-treated cells frequently have both sister kinetochores attached to microtubules extending to the center of the monoaster (syntelic orientation). Mitotic arrest–deficient protein 2 (Mad2) localizes to a sub
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Wang, Xiao Min, Ye Zhai, and James E. Ferrell. "A Role for Mitogen-activated Protein Kinase in the Spindle Assembly Checkpoint in XTC Cells." Journal of Cell Biology 137, no. 2 (1997): 433–43. http://dx.doi.org/10.1083/jcb.137.2.433.

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The spindle assembly checkpoint prevents cells whose spindles are defective or chromosomes are misaligned from initiating anaphase and leaving mitosis. Studies of Xenopus egg extracts have implicated the Erk2 mitogen-activated protein kinase (MAP kinase) in this checkpoint. Other studies have suggested that MAP kinases might be important for normal mitotic progression. Here we have investigated whether MAP kinase function is required for mitotic progression or the spindle assembly checkpoint in vivo in Xenopus tadpole cells (XTC). We determined that Erk1 and/or Erk2 are present in the mitotic
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Dissertations / Theses on the topic "Mitotic spindle checkpoint"

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Sen, Onur. "Phospho-regulation of the spindle assembly checkpoint." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/15873.

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Mitosis is a highly regulated process by which a cell duplicates and distributes its chromosomal DNA into two identical daughter cells equally. Equal distribution of the chromosomes is crucial for accurate propagation of genetic information. This is essential for maintaining viability and preventing genomic instability that can potentially lead to cancer. In order to avoid unequal distribution of chromosomes, cells employ a surveillance mechanism called the spindle assembly checkpoint (SAC). The SAC is an inhibitory signalling network, which delays segregation of chromosomes, until they have s
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Hewitt, Laura. "Using a novel small molecule inhibitor to investigate the role of Mps1 kinase activity." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/using-a-novel-small-molecule-inhibitor-to-investigate-the-role-of-mps1-kinase-activity(fcacfefc-90d9-4e92-9af4-a57897737329).html.

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During mitosis, accurate chromosome segregation is essential: gain or loss of genetic information can be detrimental to cell viability, or promote tumourigenesis. The mitotic checkpoint (also known as the spindle assembly checkpoint or SAC) ensures accurate chromosome segregation by delaying cell cycle progression until accuracy can be guaranteed. Mps1 is a protein kinase that is crucial for mitotic checkpoint signalling and also for proper chromosome alignment at metaphase. However, the precise role of Mps1’s catalytic activity is still unclear. Here, I present AZ3146, a novel small molecule
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Tipton, Aaron R. "How to Assemble a Functional Mitotic Checkpoint Complex." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1341597834.

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Cotsiki, Marina. "Identification of novel protein interactors of the SV40 large T antigen using the yeast two hybrid system." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268375.

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Sze, Man-fong. "Characterization of mitotic checkpoint proteins, MAD1 and MAD2, in hepatocellular carcinoma." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36841286.

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Leontiou, Ioanna. "'SynCheck' : new tools for dissecting Bub1 checkpoint functions." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33246.

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The accurate segregation of DNA during cell division is essential for the viability of future cellular generations. Genetic material is packaged in the form of chromosomes during cell division, and chromosomes are segregated equally into two daughter cells. Chromosome mis-distribution leads to genetic disorders (e.g. Down's syndrome), aneuploidy and cancer. The spindle checkpoint ensures proper chromosome segregation by monitoring kinetochore-microtubule interactions. Upon checkpoint activation, unattached kinetochores recruit checkpoint proteins that combine to form a diffusible inhibitor (th
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Jaffrey, Ross G. "Genomic instability in cancer : the role of the mitotic spindle checkpoint gene hBUB1." Thesis, University of Aberdeen, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400744.

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In this study, a number of human cancer cell lines were characterised for their genomic instability phenotypes: using a panel of centromeric probes utilising the fluorescence <i>in situ</i> hybridisation (FISH) technique to detect CIN, and a microsatellite assay using radioactive PCR labelling to detect MIN.  This characterisation allowed comparison of hBUB1 expression data, and assessed the differences between phenotypic cell line groups for <i>hBUB1</i> mutations and polymorphisms.  Having demonstrated the potential of radioactive-microsatellite PCR to display changes between drug sensitive
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Sze, Man-fong, and 施敏芳. "Characterization of mitotic checkpoint proteins, MAD1 and MAD2, in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38438550.

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LaBelle, Jenna J. "Characterizing BUBR1 interactions with MAD2 and p31comet during the Mitotic Checkpoint." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1533237730601357.

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Li, Deyu. "Spatial and temporal regulation of mitotic progression by the spindle checkpoint in Drosophila melanogaster." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491836.

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The spindle assembly checkpoint is a cell-cycle surveillance system which ensures the mother cell equally and faithfully separates its replicated DNA contents into two daughter cells before the onset of anaphase. Mad2, BubRl and Cdc20 (Fzy in Drosophila melanogaster) are all kinetochore proteins which dynamically turnover on and off the mitotic kinetochores. It is believed that these proteins are forming a diffusible kinetochore anaphase inhibitory signal for spindle checkpoint function, inhibiting APC/C activity in order to delay the metaphase-anaphase transition (Musacchio and Salmon, 2007).
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Book chapters on the topic "Mitotic spindle checkpoint"

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Eves, Eva M., and Marsha Rich Rosner. "MAP Kinase Regulation of the Mitotic Spindle Checkpoint." In MAP Kinase Signaling Protocols. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-795-2_31.

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Caydasi, Ayse Koca, and Gislene Pereira. "Evaluation of the Dynamicity of Mitotic Exit Network and Spindle Position Checkpoint Components on Spindle Pole Bodies by Fluorescence Recovery After Photobleaching (FRAP)." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6502-1_13.

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Gabrielli, Brian, and Mellissa Brown. "Histone Deacetylase Inhibitors Disrupt the Mitotic Spindle Assembly Checkpoint By Targeting Histone and Nonhistone Proteins." In Advances in Cancer Research. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-12-394387-3.00001-x.

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Marcozzi, Chiara, and Jonathon Pines. "Assays for the spindle assembly checkpoint in cell culture." In Mitosis and Meiosis Part A. Elsevier, 2018. http://dx.doi.org/10.1016/bs.mcb.2018.03.001.

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Conference papers on the topic "Mitotic spindle checkpoint"

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Jaiswal, Neha, Smitha Pillai, Namrata BoraSinghal, and Srikumar Chellappan. "Abstract 3460: TBK1 regulates mitotic progression by modulating spindle assembly checkpoint in cancer cells." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3460.

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Yong, Kwon Joong, Diane E. Milenic, Kwamena E. Baidoo, and Martin W. Brechbiel. "Abstract 1601: Paclitaxel potentiates212Pb-radioimmunotherapy-induced cell killing efficacy by perturbing mitotic spindle checkpoint." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1601.

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Shan, Weiwei, Patricia Y. Akinfenwa, Kari J. Brewer, Dina C. Lev, and Matthew L. Anderson. "Abstract 3001: Dysregulation of the mitotic spindle checkpoint contributes to the development of human genital tract leiomyosarcoma." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3001.

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Suraokar, Milind B., Maria Nunez, Chi-wan B. Chow, et al. "Abstract 2172: Deregulation of the mitotic spindle assembly checkpoint pathway in malignant pleural mesothelioma (MPM) tumors revealed by gene expression profiling." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2172.

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Nath, Somsubhra, Taraswi Banerjee, Debrup Sen, Tania Das, and Susanta Roychoudhury. "Abstract 3075: A novel transcriptional role of spindle assembly checkpoint protein Cdc20 regulating the expression of mitotic ubiquitin carrier protein UbcH10." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3075.

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Oshi, Masanori, Lan Le, Yoshihisa Tokumaru, et al. "Abstract 1966: Cell proliferation-related pathway scores (G2M Checkpoint, E2F Targets, MYC Targets V1 and V2, Mitotic Spindle, p53 pathway) as predictive and prognostic biomarkers in pancreatic cancer." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1966.

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Chen, Yen-An, Hung-Ju Shih, Kang-Lin Chu, et al. "Abstract A68: MCT-1 oncoprotein induces chromosomal aberrations through impairing centrosomal and mitotic-spindle checkpoints." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-a68.

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Yang, Chunying, Xi Tang, Xiaojing Guo, Stephen Wong, Li Fu, and Bo Xu. "Abstract 2991: ATM is activated in mitosis and required for the spindle checkpoint." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2991.

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Reports on the topic "Mitotic spindle checkpoint"

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Kadura, Sheila, and Shelley Sazar. Identification and Characterization of Components of the Mitotic Spindle Checkpoint Pathway Using Fission Yeast. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada408789.

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Kadura, Sheila, and Shelly Sazer. Identification and Characterization of Components of the Mitotic Spindle Checkpoint Pathway in Fission Yeast. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada421768.

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