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Relevant bibliographies by topics / Mitral leaflets

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Academic literature on the topic 'Mitral leaflets'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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Journal articles on the topic "Mitral leaflets"

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Mannan, Md Abdul, AAS Majumder, Solaiman Hossain, Mohammad Ullah, and SNI Kayes. "Effect of Mitral Valve Leaflets Excursion on Mitral Valve area after Percutaneous Trans- Venous Mitral Commissurotomy." Cardiovascular Journal 10, no. 1 (2017): 3–7. http://dx.doi.org/10.3329/cardio.v10i1.34354.

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Background: Aim of our study was to predict the effect of mitral valve leaflets excursion on mitral valve area following percutaneous transvenous mitral commissurotomy PTMC in patients of mitral stenosis.Methods: Total 70 patients with severe mitral stenosis who underwent PTMC were enrolled in the study.Transthoracic echocardiography was done the day before PTMC and 24-48 hours after PTMC. Mitral valve area, anterior and posterior leaflets excursion were recorded. The relation between leaftlet excursion and mitral valve after PTMC was evaluated.Results: Following PTMC there were significant in

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Karlsson, Matts O., Julie R. Glasson, Ann F. Bolger, et al. "Mitral valve opening in the ovine heart." American Journal of Physiology-Heart and Circulatory Physiology 274, no. 2 (1998): H552—H563. http://dx.doi.org/10.1152/ajpheart.1998.274.2.h552.

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To study the three-dimensional size, shape, and motion of the mitral leaflets and annulus, we surgically attached radiopaque markers to sites on the mitral annulus and leaflets in seven sheep. After 8 days of recovery, the animals were sedated, and three-dimensional marker positions were measured by computer analysis of biplane videofluorograms (60/s). We found that the oval mitral annulus became most elliptical in middiastole. Both leaflets began to descend into the left ventricle (LV) during the rapid fall of LV pressure (LVP), before leaflet edge separation. The anterior leaflet exhibited a

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EL Adel, Mohamed, Mohammed Mahmoud Mostafa, Ahmed Ghoneim, and Mohamed Abdelkader Osman. "Clinical and echocardiographic evaluation of patients undergoing total leaflets preservation during mitral valve replacement; Does it make a difference?" Egyptian Cardiothoracic Surgeon 1, no. 2 (2019): 32–39. http://dx.doi.org/10.35810/ects.v1i2.39.

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Background: The effect of anterior and posterior leaflet preservation on left ventricular function after mitral valve replacement is still the subject of ongoing research. The objective of this study is to analyze the early outcomes of total leaflets preservation compared to posterior and non-leaflet preservation during mitral valve surgery on cardiac function and dimensions measured by echocardiography and on the clinical outcomes.Methods: This prospective cohort study recruited 155 patients who had mitral valve replacement (MVR) from April 2016 to March 2018 at Assiut University Hospital. Pa

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Buzila, Cosmin Alexandru, Iulian Antoniac, Florin Miculescu, Marius Dumitrescu, and Ionel Droc. "Investigation of a Mechanical Valve Impairment after Eight Years of Implantation." Key Engineering Materials 583 (September 2013): 137–44. http://dx.doi.org/10.4028/www.scientific.net/kem.583.137.

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A 55-year-old female who undergone mitral valve replacement eight years ago with a mechanical graft, presented accusing sudden decrease of effort tolerance and two episodes of pulmonary edema in the last month. Anamnesis, physical examination, electrocardiogram (ECG), transthoracic echocardiography and coronarography were performed. The mechanical valve leaflets and the tissue surrounding the prosthetic ring were evaluated by: optical microscopy (hematoxylin eosin stain and immunohistochemistry), scanning electron microscopy (SEM) and EDAX analysis (Energy Dispersive X-ray spectroscopy). Anamn

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Mannan, Md Abdul, AAS Majumder, Solaiman Hossain, et al. "Effect of Subvalvular Changes on Mitral Valve Leaflets Excursion after Percutaneous Transvenous Mitral Commissurotomy." Cardiovascular Journal 8, no. 1 (2015): 8–12. http://dx.doi.org/10.3329/cardio.v8i1.24758.

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Background: Aim of our study was to predict the effect of subvalvular changes on mitral valve leaflets excursion in a patient with mitral stenosis following percutaneous trans-venous mitral commissurotomy.Methods: Total of 60 patients of severe mitral stenosis were enrolled in the study. Transthoracic echocardiography was done on the day before percutaneous trans-venous mitral commissurotomy and 24-48 hours after percutaneous trans-venous mitral commissurotomy. Subvalvular area, anterior and posterior leaflets excursion were recorded.Results: Following percutaneous trans-venous mitral commissu

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Toma, Milan, Daniel R. Einstein, Keshav Kohli, et al. "Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations." Biology 9, no. 7 (2020): 173. http://dx.doi.org/10.3390/biology9070173.

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Edge-to-edge repair for mitral valve regurgitation is being increasingly performed in high-surgical risk patients using minimally invasive mitral clipping devices. Known procedural complications include chordal rupture and mitral leaflet perforation. Hence, it is important to quantitatively evaluate the effect of edge-to-edge repair on chordal integrity. in this study, we employ a computational mitral valve model to simulate functional mitral regurgitation (FMR) by creating papillary muscle displacement. Edge-to-edge repair is then modeled by simulated coaptation of the mid portion of the mitr

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Kadyrova, M. V., N. N. Askerova, Yu A. Stepanova, et al. "Possibilities of Echocardiography at the Stages of Surgical Treatment of the Patient with the Mitral Valve Posterior Leaflet Prolapse Resulted in Mitral Insufficiency and Atrial Fibrillation (A Case Report)." Medical Visualization, no. 2 (April 28, 2017): 103–13. http://dx.doi.org/10.24835/1607-0763-2017-2-103-113.

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The mitral valve prolapse is characterized by the degeneration of the valve leaflets, accompanied by their thickening, increasing surface area and flexibility. The mitral valves leaflets bulge (prolapse) beyond the plane of the atrioventricular ring into the left atrium during ventricular systole and lose the ability to close tightly, leading to the mitral regurgitation. Acute chord rupture of the mitral valve posterior leaflet is a rare but important cause of severe mitral regurgitation and the development of acute or progressive chronic heart failure. Acute mitral insufficiency, accompanied

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Roy Chowdhuri, Kuntal, Nilanjan Dutta, Nayem Raja, et al. "Mid-Term Follow-Up of Neonatal Neochordal Reconstruction of Tricuspid Valve for Perinatal Chordal Rupture Causing Severe Tricuspid Valve Regurgitation." World Journal for Pediatric and Congenital Heart Surgery 11, no. 5 (2020): 587–94. http://dx.doi.org/10.1177/2150135120929011.

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Background: Papillary muscle rupture in the perinatal period is a rare event that leads to severe mitral or tricuspid insufficiency due to a flail leaflet. Neonatal tricuspid chordal reconstruction for this condition is rarely reported. Early recognition and treatment have the potential to be lifesaving. We present our surgical experience with five such patients, along with their midterm follow-up. Methods: Between August 2010 and November 2012, five neonates (aged 1-30 days) underwent surgery for severe atrioventricular valve regurgitation. All neonates had severe tricuspid regurgitation due

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Onan, Burak, Unal Aydin, Zeynep Kahraman, Korhan Erkanli, and Ihsan Bakir. "Robot-Assisted Mitral Valve Repair with Posterior Leaflet Extension for Rheumatic Disease." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 12, no. 1 (2017): 60–63. http://dx.doi.org/10.1097/imi.0000000000000335.

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Mitral valve repair has been one of the widely used applications of robotic surgery. Patients with rheumatic mitral disease usually present at an early age with thickening, retraction, or fusion of the leaflets and subvalvular apparatus. Robotic mitral repair can be feasible among this group of patients, rather than replacement. Herein, we describe a young woman who presented with rheumatic mitral valve insufficiency. A complex mitral repair with posterior leaflet extension with an autologous pericardial patch was successfully conducted using robot assistance.

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Itoh, Akinobu, Gaurav Krishnamurthy, Julia C. Swanson, et al. "Active stiffening of mitral valve leaflets in the beating heart." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 6 (2009): H1766—H1773. http://dx.doi.org/10.1152/ajpheart.00120.2009.

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The anterior leaflet of the mitral valve (MV), viewed traditionally as a passive membrane, is shown to be a highly active structure in the beating heart. Two types of leaflet contractile activity are demonstrated: 1) a brief twitch at the beginning of each beat (reflecting contraction of myocytes in the leaflet in communication with and excited by left atrial muscle) that is relaxed by midsystole and whose contractile activity is eliminated with β-receptor blockade and 2) sustained tone during isovolumic relaxation, insensitive to β-blockade, but doubled by stimulation of the neurally rich reg

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Dissertations / Theses on the topic "Mitral leaflets"

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Masuyama, Shinji. "Chordal translocation for ischemic mitral regurgitation may ameliorate tethering of the posterior and, anterior mitral leaflets." Kyoto University, 2009. http://hdl.handle.net/2433/124292.

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Mace, Amber. "A Comparative In Vitro Study of the Flow Characteristics Distal to Mechanical and Natural Mitral Valves." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/31540.

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Mechanical heart valve (MHV) flows are characterized by high shear stress, regions of recirculation, and high levels of turbulent fluctuations. It is well known that these flow conditions are hostile to blood constituents, which could lead to thromboembolism. In the ongoing effort to reduce long-term complications and morbidity, it is imperative that we better understand the flow characteristics of the natural valve as well as that of the mechanical valve. In this study, we overcome many of the limitations imposed by other measurement techniques by employing a powerful, high-speed Time-Reso

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McCarthy, Karen Patricia Mary. "Immunohistochemical and electron microscopic analysis of protein and connective tissue alterations in thickened myxomatous mitral valve leaflets in children and adults." Thesis, Imperial College London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577459.

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Valve degeneration is one of the most common lesions to affect the heart. Floppy mitral valve is a frequent pathology in adults but degeneration of the collagen fibres of the leaflet is also seen in children. This congenital condition is described as dysplastic mitral leaflets. Few cases have an identified genetic defect, for the majority of adults and children the cause of the disruption is unknown. In this descriptive investigation, histological and 'immunohistological methods were used on human mitral valves. Forty children, (17 dysplastic [mean 2.9 years]), 23 control leaflets [mean 4.3 ye

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Morticelli, Lucrezia. "Guided functional re-engineering of the mitral valve leaflet." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/6524/.

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Valvular heart disease is a major cause of mortality worldwide. Mitral valve regurgitation represents the second major valvular disorder in the western world. Current strategies for mitral valve reconstruction are imperfect. The aim of this study was to investigate the tissue engineering of mitral valve leaflets for mitral valve leaflets reconstruction. The approach taken was to utilise decellularised porcine pericardium seeded with porcine mesenchymal stem cells (pMSCs) and to mechanically condition the cell seeded constructs using biaxial strain in a bespoke bioreactor. The biomechanical and

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Icenogle, David A. "Development of virtual mitral valve leaflet models from three-dimensional echocardiography." Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/48994.

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Mitral valve (MV) disease is responsible for approximately 2,581 deaths and 41,000 hospital discharges each year in the US. Mitral regurgitation (MR), retrograde blood from through the MV, is often an indicator of MV disease. Surgical repair of MVs is preferred over replacement, as it is correlated with better patient quality of life. However, replacement rates are still near 40% because MV surgical repair expertise is not spread across all hospitals. In addition, 15-80% of surgical repair patients have recurrent MR within 10 years. Quantitative patient-specific models could aid these issues b

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Asgar, Anita W. "Cost-effectiveness of Transcatheter Mitral Valve Leaflet Repair for the Treatment of Mitral Regurgitation in Heart Failure." Thèse, 2016. http://hdl.handle.net/1866/13865.

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Contexte: La régurgitation mitrale (RM) est une maladie valvulaire nécessitant une intervention dans les cas les plus grave. Une réparation percutanée de la valve mitrale avec le dispositif MitraClip est un traitement sécuritaire et efficace pour les patients à haut risque chirurgical. Nous voulons évaluer les résultats cliniques et l'impact économique de cette thérapie par rapport à la gestion médicale des patients en insuffisance cardiaque avec insuffisance mitrale symptomatique. Méthodes: L'étude a été composée de deux phases; une étude d'observation de patients souffrant d'insuffisance ca

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Books on the topic "Mitral leaflets"

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Rahimi, Kazem. Mitral regurgitation. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0095.

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Mitral regurgitation (MR) is the reflux of blood from the left ventricle into the left atrium as a result of dysfunction of the mitral valve. MR can result from abnormalities of any part of the mitral valve apparatus (valve leaflets, annulus, chordae tendineae, and papillary muscles), or dilatation/disease of the left ventricle.

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La Canna, Giovanni. Heart valve disease (mitral valve disease): anatomy and morphology of the mitral valve. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0034.

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The mitral valve is a complex anatomical structure that includes the valve tissue (leaflets), the left atrioventricular junction (annulus), and the valve suspension system (chordae tendineae, papillary muscles, and left ventricle). Its functional anatomy can be analysed using two- and three-dimensional transthoracic and transoesophageal echocardiography. Based on certain hallmarks (commissures, clefts), in vivo mitral valve tissue anatomy can be accurately categorized. In addition, three-dimensional reconstruction provides a quantitative model for comprehensive valve analysis. This chapter des

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Muraru, Denisa, Ashraf M. Anwar, and Jae-Kwan Song. Heart valve disease: tricuspid valve disease. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0037.

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The tricuspid valve is currently the subject of much interest from echocardiographers and surgeons. Functional tricuspid regurgitation is the most frequent aetiology of tricuspid valve pathology, is characterized by structurally normal leaflets, and is due to annular dilation and/or leaflet tethering. A primary cause of tricuspid regurgitation with/without stenosis can be identified only in a minority of cases. Echocardiography is the imaging modality of choice for assessing tricuspid valve diseases. It enables the cause to be identified, assesses the severity of valve dysfunction, monitors th

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Rigo, Fausto, Covadonga Fernández-Golfín, and Bruno Pinamonti. Familial cardiomyopathies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0047.

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The tricuspid valve is currently the subject of much interest from echocardiographers and surgeons. Functional tricuspid regurgitation is the most frequent aetiology of tricuspid valve pathology, is characterized by structurally normal leaflets, and is due to annular dilation and/or leaflet tethering. A primary cause of tricuspid regurgitation with/without stenosis can be identified only in a minority of cases. Echocardiography is the imaging modality of choice for assessing tricuspid valve diseases. It enables the cause to be identified, assesses the severity of valve dysfunction, monitors th

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Feldman, Ted, ed. Percutaneous Mitral Leaflet Repair. CRC Press, 2012. http://dx.doi.org/10.3109/9781841849669.

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Feldman, Ted, and Frederick St Goar. Percutaneous Mitral Leaflet Repair. Taylor & Francis Group, 2012.

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Henderson, Deborah J., Bill Chaudhry, and José Luis de la Pompa. Development of the arterial valves. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0018.

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The arterial valves guarding the entrances to the aorta and pulmonary trunk have many similarities to the mitral and tricuspid valves in the atrioventricular region of the heart. Despite these similarities, there are significant differences in the formation and structure of the arterial and atrioventricular valves. The most fundamental of these relate to the lineage origins of the cells forming the primitive cushions. Although the fate of the different lineages remains unclear, each makes a permanent contribution to the mature valve. Arterial valve formation is intrinsically linked to cushion

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Basso, Cristina, Gaetano Thiene, and Siew Yen Ho. Heart valve disease (aortic valve disease): anatomy and pathology of the aortic valve. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0031.

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The gross features of the aortic valve apparatus, consisting of three semilunar leaflets, three interleaflet triangles, three commissures, and the aortic wall, are discussed both in terms of normal and pathological anatomy. The concept of aortic annulus and the relationship of the aortic valve with the coronary arteries, the membranous septum, and conduction system and the mitral valve are addressed. When dealing with pathology, the chapter focuses on the main distinctive features of aortic valve stenosis and aortic valve incompetence. Regarding the former, the abnormalities reside in the cusp

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Popescu, Bogdan A., Shantanu P. Sengupta, Niloufar Samiei, and Anca D. Mateescu. Heart valve disease (mitral valve disease): mitral stenosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0035.

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The most common cause of mitral stenosis (MS) is rheumatic fever followed by degenerative MS. Echocardiography is the key method to diagnose and evaluate MS. Echocardiographic findings are closely related to aetiology. In rheumatic disease echocardiography shows thickening of leaflet tips with restricted opening caused by commissural fusion resulting in ‘doming’ of the mitral valve in diastole. Quantitation of MS severity includes measuring mitral valve area (MVA) by planimetry (anatomical area, by two-/three-dimensional echo), or by the pressure half-time (PHT) method (functional area, by Dop

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Płońska-Gościniak, Edyta, Michal Ciurzynski, Marcin Fijalkowski, et al. Cardiac involvement in systemic diseases. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0057.

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Cardiovascular features in systemic diseases are common. Transthoracic echocardiography represents a first-line diagnostic tool among these patients. Pericarditis is the most frequent cardiac complication of rheumatoid arthritis. In systemic lupus erythematosus, echocardiography shows usually small or moderate pericardial effusion in up to 55% of patients. In this group, Libman-Sacks vegetations develop mainly on the mitral valve but also can be seen on other valves. Pulmonary hypertension is one of the most important complications adversely influencing survival of systemic sclerosis patients.

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Book chapters on the topic "Mitral leaflets"

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Schneider, Robert J., William C. Burke, Gerald R. Marx, Pedro J. del Nido, and Robert D. Howe. "Modeling Mitral Valve Leaflets from Three-Dimensional Ultrasound." In Functional Imaging and Modeling of the Heart. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-21028-0_27.

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Enriquez-Sarano, M., J. F. Avierinos, L. H. Ling, F. Grigioni, D. Mohty, and C. Tribouilloy. "Surgical Treatment of Degenerative Mitral Regurgitation: Should We Approach Differently Patients with Flail Leaflets of Simple Mitral Valve Prolapse?" In Pathophysiology, Evaluation and Management of Valvular Heart Diseases, Vol. 2. KARGER, 2004. http://dx.doi.org/10.1159/000079788.

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Bunting, Haley, Megan E. Murphy, and Heather Pemberton. "Flail Mitral Leaflet." In Learning Cardiac Auscultation. Springer London, 2015. http://dx.doi.org/10.1007/978-1-4471-6738-9_10.

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Leung, Alexander K. C., Marcus Schmitt, Christie P. Thomas, et al. "Billowing Mitral Leaflet Syndrome." In Encyclopedia of Molecular Mechanisms of Disease. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_6272.

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Maisano, Francesco, Joerg Seeburger, Paolo Denti, Friedrich W. Mohr, and Ottavio Alfieri. "Transcatheter mitral leaflet repair." In Endovascular and Hybrid Therapies for Structural Heart and Aortic Disease. John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118504536.ch18.

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Moorjani, Narain, Bushra S. Rana, and Francis C. Wells. "Bi-leaflet Prolapse." In Operative Mitral and Tricuspid Valve Surgery. Springer London, 2018. http://dx.doi.org/10.1007/978-1-4471-4204-1_9.

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Moorjani, Narain, Bushra S. Rana, and Francis C. Wells. "Posterior Mitral Valve Leaflet Prolapse." In Operative Mitral and Tricuspid Valve Surgery. Springer London, 2018. http://dx.doi.org/10.1007/978-1-4471-4204-1_7.

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Moorjani, Narain, Bushra S. Rana, and Francis C. Wells. "Anterior Mitral Valve Leaflet Prolapse." In Operative Mitral and Tricuspid Valve Surgery. Springer London, 2018. http://dx.doi.org/10.1007/978-1-4471-4204-1_8.

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Ng, Choi-Keung. "Classification of mitral insufficiency according to leaflet mobility." In Modern Mitral Valve Repair. Springer Vienna, 2003. http://dx.doi.org/10.1007/978-3-7091-3721-5_2.

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Ng, Choi-Keung. "Combined reconstruction with leaflet extension plasty (Fig. 23)." In Modern Mitral Valve Repair. Springer Vienna, 2003. http://dx.doi.org/10.1007/978-3-7091-3721-5_8.

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Conference papers on the topic "Mitral leaflets"

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He, Zhaoming, and Shamik Bhattacharya. "Mitral Valve Annulus Tension." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192247.

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The mitral valve annulus is an anatomical structure joining the leaflets and left ventricle wall. It is divided into the fibrous annulus in the anteromedial section and the myocardium annulus in the posterolateral section, according to annulus histology. Two trigones are in the fibrous annulus. Mitral annulus supports leaflets in the valve coaptation and controls inflow hemodynamics during a cardiac cycle. When the mitral valve is fully open during diastole, inflow drag force on the leaflets and chordae pulls the leaflets approximately apically. As mitral valve leaflets coaptate during systole

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Norwood, Carolyn G., and W. David Merryman. "Biaxial Compliance Changes of Mitral Valve Leaflets Following Radiofrequency Ablation." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206761.

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The mitral valve (MV), located between the left atrium and left ventricle of the heart, is responsible for preventing retrograde blood flow by closing during systole. There are two MV leaflets, anterior and posterior. The anterior is the larger of the two and semicircular; the posterior leaflet is more rectangular and can be subdivided into three scallops, the middle scallop being the largest in most human hearts. The two leaflets are anchored to the wall of the left ventricle by the chordae tendinae. The MV annulus forms a complete fibrous ring anchored along the anterior leaflet (1).

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Shultz, Tyler, Manuel Rauch, and Ellen Kuhl. "Collagen Orientation in the Anterior Mitral Valve Leaflet." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53191.

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The Mitral Valve (MV) serves to ensure unidirectional blood flow from the pulmonary to systemic circulation. When the MV fails to function correctly, backflow from the left ventricle to left atrium occurs during heart contraction. This condition is called Mitral Valve Regurgitation (MVR) and is estimated to affect 2 to 2.5 million people in the United States alone [1]. Surgical techniques exist to repair MVR, and each affects the structure of the valve in a different way [2]. As the main load-bearing structure in the leaflets, collagen fibers have a tremendous impact on how the leaflets are ab

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Javid, Farhad, Nastaran Shahmansouri, Marco Amabili, Rosaire Mongrain, Damiano Pasini, and Jorge Angeles. "Identification of the Toughness Properties of Mitral Valve Leaflets." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14738.

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Suturing a prosthetic ring to the mitral valve is one of the main challenges in percutaneous mitral valve annuloplasty. Novel self-anchoring fasteners developed for minimally invasive surgery may easily tear the tissue and cause their failure. Identification of the fracture toughness of the mitral valve tissue is an important step towards the optimization of these novel fasteners to minimize their deleterious effects on the surrounding tissue. Moreover, the study of rupture mechanism of the heart valve tissue can provide interesting information on the developing process of congenital mitral re

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Wenk, Jonathan F., Zhihong Zhang, Guangming Cheng, et al. "A Method for Developing MRI-Based Finite Element Models of the Left Ventricle With Mitral Valve and Chordae Tendineae." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19671.

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Ischemic mitral regurgitation (MR) affects 1.2 to 2.1 million patients in the United States, with more than 400,000 patients having moderate-to-severe MR [1]. As a consequence of left ventricular remodeling after postero-basal myocardial infarction (MI), the posterior papillary muscle moves laterally. This causes both anterior and posterior mitral leaflets to be tethered, and type 3B Carpentier leaflet motion (restricted motion during systole) and ischemic MR to occur.

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He, Zhaoming, Suveen Emmadi, and Shamik Bhattacharya. "Effects of Edge-to-Edge Repair on Chordal Tension of Prolapsed Mitral Valve." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204845.

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Edge-to-edge repair (ETER) was introduced to correct mitral valve (MV) regurgitation and has demonstrated efficacy in a spectrum of MV diseases [1], especially MV prolapse. This technique changes MV geometric configuration by suturing the anterior and posterior leaflets at central or commissural edges (depending on lesion), and consequently alters MV mechanics. MV prolapse is the most common heart valve abnormality in the United States. It is mainly caused by chordal rupture or elongation in which imbalanced chordal lengths protrude MV anterior and/or posterior leaflets. Chordal repair or leaf

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Padala, Muralidhar, Lazarina I. Gyoneva, and Ajit P. Yoganathan. "Impact of Secondary Chordal Cutting on Mitral Valve Closure and Chordal Force Distribution in an Ischemic Dilated Ventricle: Engineering Insight and Clinical Implications." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206564.

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The Mitral Valve (MV) is the left atrioventricular valve that controls blood flow between the left atrium and the left ventricle (Fig 1A-B). It has four main components: (i) the mitral annulus – a fibromuscular ring at the base of the left atrium and the ventricle; (ii) two collagenous planar leaflets – anterior and posterior; (iii) web of chordae tendineae – classified into primary (inserting at the free edge of the leaflet), secondary (inserting into the base of the leaflet), tertiary (inserting into the annulus); and (iv) two papillary muscles that are part of the left ventricle. Normal fun

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Krishnamurthy, Gaurav, Akinobu Itoh, Wolfgang Bothe, et al. "Quantification of In Vivo Stresses in the Ovine Anterior Mitral Valve Leaflet." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192295.

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Mitral valve (MV) disease affects millions worldwide. An important goal of present-day heart valve research is to create bioengineered tissue valves to replace diseased mitral valves, if it is judged that mitral repair will not be durable. The design of such valves will pivot on understanding the stresses acting in the native MV leaflets to design a bioprosthesis which will withstand these stresses. In order to quantify such stresses in vivo, we utilized radiopaque marker technology and performed an “inverse” finite element analysis of the resulting 4-D data to determine the material propertie

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Shahmansouri, Nastaran, Farhad Javid, Damiano Pasini, Jorge Angeles, Marco Amabili, and Rosaire Mongrain. "Investigation of the Fatigue Properties of Mitral Valve Leaflets." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14758.

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Annulus dilation is one of the main causes of functional mitral regurgitation. Although the annulus dilation is usually accompanied by left ventricle dilation and dysfunction, the mechanical relation between them is not fully elucidated yet. In this paper, the assumption is made that the ventricular dysfunction increases the cyclic loading conditions on the mitral valve apparatus. This effect may cause fatigue and weaken the tissue. This hypothesis is investigated in vitro by applying increased cyclic loadings to the tissue and evaluating the tissue stiffness during the cycles. The results of

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Mace, Amber R., Pavlos P. Vlachos, and Demetri P. Telionis. "On the Interaction of Natural and Mechanical Heart Valve Leaflets With the Chordae Tendineae." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32571.

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Abstract:

Long before mitral valve replacement (MVR) became a routine operation, physiologic studies indicated that the continuity of mitral leaflets with papillary muscles, chordae tendineae (CT) and the atrioventricular ring may play a decisive role in the function of the left ventricle (LV) [1]. This led Lillehei et al. [2] to establish a procedure whereby the posterior leaflet, its CT and papillary muscles were preserved in MVRs. These and other studies indicated a significant reduction of postoperative mortality compared to conventional MVR. Though developed in the early 1960s by Lillehei, the tech

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