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Dissertations / Theses on the topic 'MKTP'

Author: Grafiati

Published: 1 July 2021

Last updated: 29 July 2025

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1

Ahmed, Refat Maggi. "Improving the Success of Melanocyte Keratinocyte Transplantation Surgery in Vitiligo; The Role of JAK Inhibitors, and Ablative Laser Resurfacing." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1143.

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The Melanocyte Keratinocyte Transplantation Procedure (MKTP) is an effective surgical replacement of lost melanocytes in recalcitrant vitiligo and pigmentary skin disorders. However, it is only effective in stable vitiligo lesions because active autoimmunity destroys the newly transplanted melanocytes. Despite careful selection of candidates based on the reported clinical stability, the success of the procedure is still unpredictable. MKTP candidates with non-segmental, segmental, and mixed vitiligo, as well as hypopigmented scars and Piebaldism patients were enrolled to our studies. Our aim w

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Brondello, Jean-Marc. "Les map kinase phosphatases (mkp)-1, mkp-2 et mkp-3 : regulation et fonctions dans les fibroblastes." Nice, 1997. http://www.theses.fr/1997NICE5207.

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La principale caracteristique de la phosphorylation des proteines cellulaires est sa reversibilite. Dans la cellule, il existe une balance entre la phosphorylation (assuree par des kinases) et la dephosphorylation (assuree par des phosphatases) des proteines. Une modification de cette balance est a l'origine d'une grande partie des mecanismes permettant la transmission des signaux extracellulaires vers le noyau. Les phosphatases sont generalement divisees en trois grandes familles : les serine/threonine phosphatases, les tyrosine phosphatases et les phosphatases a double specificite. Map kinas

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Hlaváč, Martin. "Srovnání MKP modelů spojů." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229961.

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This thesis deals with the comparison of alternative models of the simplified joints used in the FEM models of complex models with detailed joint details. This is essentially a screw connection with dowel bolt and standard bolt, weld connection "T" and overlap weld connection. Individual connections are compared in the simulation results of matching models.

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Brhlík, Rostislav. "MKP simulace elastohydrodynamického kontaktu." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-231788.

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This diploma thesis deals with an application of the finite element method on elastohydrodynamic (EHD) lubrication simulations. Commercially available software COMSOL is used for the computation, while two different modules for modeling EHD lubrication are described in a detail. Firstly, a new approach using the module Thin-Film Flow is developed, considering and describing some limitations of this approach. This is the very first published work dealing complex with EHD simulation in Thin-Film Flow module. In the second part of the thesis, there was created a model of line contact using the mo

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Makki, Zbyněk. "Analýza nadproudové spouště pomocí MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218818.

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The aim of the project was to prepare the given model of the current path in the environment of the SolidWorks programme, in order to simulate the flow path in the environment of the Ansys programme, where there was calculated the distribution of current density,voltage drops and heat loss on the the specified current track according to specified conditions. The obtained results are analyzed at the conclusion of this work.

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Bezrouková, Martina. "Simulace válečkování pomocí explicitní MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230340.

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The purpose of this work is to introduce explicit finite element method (FEM) and to familiarize with commercial software tools witch are capable to perform simulations. The technological conditions and the scope of application of roller burnishing are described in subsequent part. The simulation model of roller burnishing was created. Software ANSYS LS-DYNA was used to make computations. The results of simulation and technical and economical benefits of roller burnishing are presented in the conclusion.

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Procházka, Josef. "MKP model piezoelektrických MEMS filtrů." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231204.

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This thesis focuses on simulation modelling of a piezoelectric MEMS filter, which may be used as a part of cochlear implant. A model of this filter is created in the programme ANSYS. A research on experimental cochlear implants and materials suitable for this application is also included.

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Zahradníček, Pavel. "Analýza ztráty integrity nádrže pomocí MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231310.

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This diploma thesis deals with the storage tanks for petroleum products. The introductory part is devoted to the distribution of the storage tanks, associated standards and maintenance of tanks. Another part goes about the analysis of real case of a tank collapse. There was created a 3D model of the collapsed tank according to the measured values in the tank. It was created a tank shell model by drawing documentation and analysis of the results of the accident investigation using the finite element method (FEM) by program ANSYS. Calculation was performed on the buckling resistance of the struc

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Diviš, Vladimír. "Numerické analýzy MKP v oblasti technologie svařování." Doctoral thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2007. http://www.nusl.cz/ntk/nusl-233828.

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Ševčík, Martin. "Analýza ztráty integrity uskladňovací nádrže pomocí MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2018. http://www.nusl.cz/ntk/nusl-378382.

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This master thesis is focused on computational modelling of critical external as well as internal pressure acting of the repaired tank. During cleaning of pipelines, the gas mixture entered into this storage tank causing loss of integrity in the connection between the roof and the shell. The first part of the thesis is focused on check calculation of the shell in exceptional conditions. The next part describes the repair of the tank including check of the pillar according to ČSN EN 1993 1 1 and ČSN EN 1993-1-6. The main part of the thesis is focused on determination of the buckling resistances

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Volf, Tomáš. "Analýza magnetického pole pomocí MKP a magnetické sondy." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218786.

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The magnetic field analysis by MKP and magnetic probe project deals with magnetic field analysis of asynchronous machine cross section. This analysis is written in detail along with the necessary theory of asynchronous machine and the ANSYS program. The magnetic field of selected machine is measured by magnetic probe and results are compared with calculation. The next part of thesis is draft of device for the magnetic field analysis.

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Ficza, Tibor. "Modelování přechodných dějů u synchronních stroju pomocí MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218788.

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Táto práca sa zaoberá s modelovaním synchronného stroja s permanentnými magnetmi pomocou metody konečných prvkov. K modelovaniu sme si zvolili 3 fázový synchronný stroj s permanentnými magnetmi na povrchu rotora z firmy VUES. Najprv vypočítame parametre stroja a potom spravíme statický model pomocou programu FEMM a Matlab a budeme hladať možné riešenia na 2D dynamický model. Pomocou programu Ansys Workbench spravíme 3D model tohoto stroja budeme a porovnávať výsledky simulácie.

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Biječek, Tomáš. "Deformačně-napjatostní analýza ojnice spalovacího motoru pomocí MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228164.

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In this diploma thesis is completed the FEM analysis of connecting rod in combustion engine Briggs & Stratton of the garden lawnmower. Within the frame of computing in the FEM system ANSYS Workbench is solved static structural strein and stress analysis, buckling analysis a fatigue also. The boundary conditions for FEM computing come out from the kinematic and dynamic analysis of the crank-slider mechanism in combustion engine. The 3-D models of the crank-slider mechanism are created in parametric SolidWorks modeller. Own construction variants of the connecting rod based on results of FEM anal

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Chromek, Lukáš. "Komplexní strukturální analýza kompresorového kola s využitím MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230442.

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This thesis explores the utilization of FEM software ANSYS in the analysis of the real blade wheel of a radial compressor used in small turbine aviation motors. This apparatus is made by První brněnská strojírna a.s., and its detached site in Velká Bíteš where it has the aviation engineering division. The aim of this thesis is a comprehensive blade wheel analysis composed of several steps. These steps include static and elasto-plastic strength analysis, which describes stress distribution and its assessment from the perspective of boundary conditions of elasticity during the use of the Hooke a

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Åhlin, Mikaela. "Role of MKP-2 in crosstalk between MAPK pathways." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-261777.

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Abnormalities in Mitogen Activated Protein Kinase (MAPK) signalling may affect the cells essential processes and influence the cell in acquiring traits to favour tumorigenic transformation and the progression of cancer. Deregulation of the MAPK pathways and uncontrolled crosstalk occurring in cancers may be caused by deregulation by MAP-kinase phosphatases (MKPs) that negatively regulates MAPKs by dephosphorylation. In this study, we were interested in the role of MKP-2 in MAPK-signalling pathways. MKP-2 is known to specifically dephosphorylate the MAP kinases Erk1/2, p38 and JNK. In this stud

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Ševčík, Martin. "Výpočtové modelování deformačně-napěťových stavů čelního soukolí pomocí MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-227992.

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This diploma thesis deals with computation modeling of spur gearing using FEM. The methodology of checking calculation was suggested for gears which are not possible to check only by using standard ČSN 01 4686. The analysis of influence of vicinity of stress concentration on stress distribution in tooth root was performed. It is possibility to use the gears with thinner rim than the standard ČSN 01 4686 recommends. The main part of this work is devoted to fatigue crack propagation study in gears with thin rim. Aiding T-stress the influence of constraint and stress multiaxiality on crack propag

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Civín, Adam. "Stanovení zbytkové napjatosti metodou vrtání otvoru s využitím MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228325.

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Residual state of stress in structural materials affect positively or negatively behaviour of component parts. The goal of this scope is not to deal with possible process of creating residual stresses neither about elimination of residual stress, but is focused how to determine magnitude of residual stress by hole-drilling method. We need to know magnitude and direction (angular orientation) of principal stresses to determine how residual state of stress affects behaviour of specimen. The most widely used modern technique for measuring residual stresses is hole-drilling strain-gage method. Hol

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Churý, Tomáš. "Stanovení modálních charakteristik celokompozitového křídla s využitím MKP metod." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-232093.

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The diploma thesis deals with the creation of a detail FEM model all-composite wing of glider. Reduction created FEM model of the beam model. The models are calculated natural frequencies, vibration shapes wings and then subsequently compared the results of analyzes of both models.

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Exertier, Prisca. "Rôle des kinésines mitotiques Eg5 et MKLP-2 dans l’angiogenèse physiologique et pathologique." Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14621/document.

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Rôle des kinésines mitotiques Eg5 et MKLP-2 dans l’angiogenèse physiologique etpathologique.L’angiogenèse est un phénomène biologique complexe qui correspond à la formation de nouveauxvaisseaux à partir de vaisseaux préexistants. Ce processus essentiel est régulé par des nombreuxfacteurs, dont le plus puissant est le facteur de croissance de l’endothélium vasculaire (VEGF).Des inhibiteurs du VEGF sont actuellement utilisés dans le traitement de nombreux cancerssolides. Leur efficacité est constatée dans plusieurs études mais des résistances contre cesmolécules sont fréquemment observées. Afin

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Bittner, Jiří. "Srovnávací analýza napětí součástí s vruby pomocí fotoelasticimetrie a MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228090.

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The diploma thesis deals with comparative analysis of stress and strain of notched machine parts using photoelasticity and finite element method (FEM). Experimental and numerical comparative analyses were performed on three models: hook, J shaped bracket and 3-point bending beam with notch. Equivalent stresses, principal stresses and its directions were analyzed. The emphasis is given on photoelasticity, the theory and principles of photoelasticity are described in more detail. FEM analysis was performed using software ANSYS 11. The work presented includes the preparation of polariscope in the

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Kubík, Petr. "Implementace, kalibrace a využití podmínek tvárného lomu v programech MKP." Doctoral thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-234356.

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The presented work is concerning with ductile fracture problematic under monotonic loading which is result of gradual material degradation at large plastic deformation. At present, a large number of models, which calibration is not trivial, are used for its prediction. Ductile fracture mechanisms and cut-off region are described in the literature search part. Next, there is given a summary of criteria which are based on different approaches to ductile fracture. There were proposed and used KHPS and KHPS2 criteria within this PhD thesis. Procedure of assessment of the stress-strain curve and du

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Gonzalez, Jara Fabian Rodrigo. "Mechanisms regulating expression of the mkp-1 gene in cardiac myocytes." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428678.

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Sloss, Callum. "Control of subcellular distribution of the MAP kinase phosphatase, MKP-2." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288715.

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Michailidis, Petr. "Analýza způsobu zakončení statorového a rotorového svazku synchronních strojů pomocí MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218802.

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This thesis deals with simulation’s possibilities of the electromagnetic fields in electrical machines. A finite element method is the final element technique. The content of this thesis is a model and mesh creation and electromagnetic simulation of synchronous machine. The stator and rotor pack termination effect on the synchronous machine.is analyzed by finite element method in ANSYS program. The type of the stator termination pack is described by four segments. The magnetic field distribution is deformed due to the material properties of used segments. In the next part a methodics of mesh c

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Jelínek, Martin. "Návrh rámu horského kola a jeho deformačně napěťová analýza pomocí MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228304.

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The aim of this diploma thesis is the part of evolution of the new bicycle frame for mountain biking, category enduro. The first part of this thesis is focused on creating dimensional modified model of the bike frame in CAD system SolidWorks. Subsequently this frame will be detailed by FEM analysis in software ANSYS Workbench and determine boundary conditions for this analysis. The final part is about visualization of the new bike frame.

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Bartoš, Radko. "Návrh temperovaného stolu pro FDM 3D tiskárnu s využitím simulace MKP." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231051.

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Master´s thesis deals with desing of a heated bed for FDM 3D printer using the finite element method. It is briefly described the history of RepRap printers, construction and mechanical parts. Are discussed two methods of heating, heated by PCB boards and using power resistors. Furthermore is work closely focused on power resistors. There are presented methods and procedures which leads to an optimal distribution of heated components on the board of heated bed. In conclusion are presented results of testing which are compared with the simulations in ANSYS.

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Singh, Aditi [Verfasser], and Christine [Akademischer Betreuer] Clayton. "Functional characterization of MKT1 and PBP1 proteins in Trypanosoma brucei / Aditi Singh ; Betreuer: Christine Clayton." Heidelberg : University of Heidelberg press, 2013. http://d-nb.info/1177382628/34.

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Rojo, Todo Federico. "Efecto de la Doxorubicina sobre MKP-1 en el Cáncer de Mama Humano y Asociación entre la Expresión de MKP-1 y la Evolución de las Pacientes." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/117477.

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Objetivos: La fosfatasa 1 de las protein-quinasas activadas por mitógenos (Mitogen-activated protein kinase (MAPK) phosphatase-1, MKP-1) regula por defosforilación la actividad de las vías de señalización de las protein-quinasas activadas por mitógenos, la quinasa regulada por señales extracelulares (extracellular signal-regulated kinase, ERK), la quinasa terminal c-Jun (c-Jun NH2-terminal kinase, JNK) y p38. MKP-1 también media en los mecanismos de quimioresistencia en cáncer de mama y se inhibe por la actividad de la doxorrubucina en modelos celulares de cáncer de mama. Este trabajo a

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Lawan, Ahmed. "The role of map kinase phosphatase-2 (MKP-2) in cardiac function." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=14506.

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Drake, John H. "Crossover control in selection hyper-heuristics : case studies using MKP and HyFlex." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14276/.

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Hyper-heuristics are a class of high-level search methodologies which operate over a search space of heuristics rather than a search space of solutions. Hyper-heuristic research has set out to develop methods which are more general than traditional search and optimisation techniques. In recent years, focus has shifted considerably towards cross-domain heuristic search. The intention is to develop methods which are able to deliver an acceptable level of performance over a variety of different problem domains, given a set of low-level heuristics to work with. This thesis presents a body of work

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Wancket, Lyn Miller. "Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385390100.

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Plachý, Jiří. "MKP analýza nosiče rotační hlavy vrtné věže a návrh na jeho úpravu." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2018. http://www.nusl.cz/ntk/nusl-377879.

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This diploma thesis deals with FEM analysis and optimization of carriage for top drive system of drilling rig Bentec 350 AC and it is defined as a development contract for company MND Drilling & Services a.s. Intensive drilling leads to damages and repeated occurrence of fatigue cracks on carriage especially along edges of welded ribs in their heat-affected zone. The aim of this thesis is to draft construction improvements of carriage which leads to elimination of damages. Realization of this modifications depends on correct definition of boundary conditions, analysis of damage occurrence as w

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Gadd, Kolby J. "Teachers' Curricular Reasoning and MKT in the Context of Algebra and Statistics." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/5686.

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This study investigates 7th grade teachers' curricular reasoning and MKT in algebra and statistics. Although the use of curriculum materials and MKT both influence the quality of mathematics instruction, no relationship between teachers' curricular reasoning and MKT was found. Further, teachers' curricular reasoning across algebra and statistics was very similar despite differences in these fields and differences in MKT. A model for thinking about the knowledge needed to provide high quality instruction is proposed by considering the role of curricular reasoning and MKT in instruction.

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Konečný, Michael. "Porovnání analytického a numerického MKP řešení vzpěrné stability laminátových kompozitních válcových skořepin." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2013. http://www.nusl.cz/ntk/nusl-230525.

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Tato práce zkoumá možností řešení kritické síly vzpěrné stability laminátových kompozitních válcových skořepin jak analytickým tak MKP přístupem. Analytické řešení je prezentováno detailně a je zpracován Matlab program pro jeho výpočet. MKP řešení je prováděno ve dvou řešičích softwaru MSC.Nastran, jsou zjišťována vhodná nastavení těchto řešičů a jejich chování. Všechny způsoby řešení jsou na závěr porovnány a je navrženo několik závěrů.

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Schooley, Jason N. "Motivational differences between self-reported user groups of the MKT Nature and Fitness Trail." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5067.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on September 29, 2008) Includes bibliographical references.

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Ševeček, Oldřich. "Řešení obecných koncentrátorů napětí v anisotropních prostředích pomocí kombinace MKP a teorie komplexních potenciálů." Doctoral thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2009. http://www.nusl.cz/ntk/nusl-233849.

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Disertační práce se věnuje problematice obecných koncentrátorů napětí v anisotropních prostředích. Zejména se jedná o problém trhlin končících na rozhraní dvou různých materiálů, či problém obecného více-materiálového klínu. Cílem práce je vytvořit komplexní nástroj pro posuzování obecných koncetrátorů napětí tj, popis pole napětí v jeho okolí, zahrnutí případného vlivu přemostění trhliny do výsledného pole napětí a definici lomových kritérií pro obecný koncentrátor v anisotropním prostředí. U popisu pole napětí je využit tzv. Lechnického-Strohův formalismus a technika spojitě rozložených disl

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Bryngelsson, Erik. "Mathematical Knowledge for Teaching (MKT) i praktiken : Vilka kunskaper krävs för att undervisa matematik?" Thesis, Södertörns högskola, Lärarutbildningen, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-43021.

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The following study aims to examine the special mathematical knowledge needed in order to teach mathematics. Furthermore, the study attempts to explore how teachers’ views on the knowledge needed in order to teach mathematics affects their student’s opportunities to develop their conceptual understanding. Qualitative and quantitative empirical data was attained by observations and complementary interviews. A total of three teachers, all working at the same school, was observed and interviewed. The study used Ball, Thames & Phelps (2008) practice-based theory of mathematical knowledge for t

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Mažeikaitė, Vaida. "Mokomųjų kompiuterinių priemonių leidyba Lietuvoje." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20081203_203545-69029.

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Magistro darbo objektas – mokomųjų kompiuterinių priemonių leidyba. Darbo tikslas – ištirti lietuviškų mokomųjų kompiuterinių priemonių leidybos procesą, pasiūlą ir ją įtakojančius veiksnius. Pagrindiniai darbo uždaviniai: išanalizuoti MKP gamybos procesą; išanalizuoti Lietuvoje leidžiamų MKP pasiūlą; sudaryti lietuviškų originalių MKP sąrašą; ištirti MKP leidybą labiausiai įtakojančius veiksmus; ištirti MKP platinimo veiksnius, analizuojant pasirinktos leidyklos atvejį. Naudojantis informacijos paieškos ir sisteminimo, dokumentų analizės, anketiniu ir lyginamuoju metodais, prieita prie išvado

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Appelman, Jaco H. "Governance of global interorganizational tourism networks : changing forms of co-ordination between the travel agency and aviation sector = Coordinatie van mondiale interorganisationele toerisme netwerken : veranderende vormen van coordinatie tussen reisagenten en de luchtvaart sector /." Rotterdam : Erasmus Research Institute of Management (ERIM), Rotterdam School of Management, Rotterdam School of Economics, Erasmus University Rotterdam, 2004. https://ep.eur.nl/retrieve/2750/EPS-2004-036-MKT+9058920607+APPELMAN.pdf.

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Le, Roux Heloise. "The effect of MKP-1 inhibition on the cytotoxicity of chemotherapeutic drugs in breast cancer." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71779.

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Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Introduction: Cancer is an emerging health problem in South Africa, with breast cancer being one of the leading cancers affecting women globally. Therefore, there is a need to find novel targets to improve the therapeutic options for these patients. A recently proposed target is the mitogen-activated protein kinase phosphatase-1 (MKP-1). Studies have suggested that mitogen-activated protein kinase phosphatases are involved in the development of cancer and play an important role in the response of cancer cells to chemotherapy. Ad

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Fodor, Ján. "Určování mechanických charakteristik materiálů vícevrstvých struktur s využitím metody zvukové rezonance a modální MKP analýzy." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318138.

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Thesis deals with determination of layerwise mechanical properties of composite ceramics by indirect method, namely Youngs modulus. Based on literature review, it was found that a method to determine elastic properties of one or more components of multi layered composites based on experimental modal analysis and finite element modal analysis, or analytical approach exists. Method based on FE modal analysis was applied to ceramic laminate, where it was attempt to determine youngs modulus of one component. Beyond that, it was attempt to determine Youngs moduli of both components using first two

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Neamatallah, Thikryat A. "The role of mitogen-activated protein kinase phosphatase-2 (MKP-2) in macrophage development and gene expression." Thesis, University of Strathclyde, 2014. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23627.

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Mitogen-activated protein kinase phosphatase-2 (MKP-2) is a type 1 nuclear dual specific phosphatase (DUSP4) and an important immune regulator. It specifically dephosphorylates the MAP kinases ERK and JNK to influence pro- and antiinflammatory cytokine production. MKP-2 has recently been shown to play a significant role in controlling Leishmania mexicana infection (Al-Mutairi et al., 2010) primarily by influencing macrophage activity. However, information on the effect of MKP-2 deletion at the molecular level on macrophage development and function is limited. This project utilised a novel DUSP

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Prabhala, Pavan. "The impact of precise MKP-1 regulation and modulation on cytokine expression in asthma and airway remodelling." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/14954.

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Asthma is a chronic inflammatory disease characterised by airway obstruction, hyperresponsiveness and remodelling. Cytokines drive many inflammatory diseases and change the balance of inflammatory and anti-inflammatory molecules along the underlying molecular pathways. Hence targeting the molecular mechanisms responsible for cytokine secretion allows us to develop novel strategies to repress inflammation. Harnessing the power of endogenous anti-inflammatory proteins is one such strategy. In this study we investigate the p38 MAPK-mediated anti-inflammatory molecule; mitogen-activated protein ki

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Fürst, Robert. "Identification of MKP-1 as a central mediator of cytoprotective effects in human endothelial cells: pathways of induction." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-31444.

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Pauli, Luciana Santos Souza 1979. "Efeitos do exercício físico sobre a associação MKP-3/FoxO1 em tecido hepático de camundongos obesos e diabéticos." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/244472.

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Orientador: Eduardo Rochete Ropelle<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas<br>Made available in DSpace on 2018-08-24T14:06:26Z (GMT). No. of bitstreams: 1 Pauli_LucianaSantosSouza_M.pdf: 2136192 bytes, checksum: ba071049e1cda0b7eb5230076d5d4b4e (MD5) Previous issue date: 2013<br>Resumo: A proteína MKP-3 (MAPK phosphatase-3) possui capacidade de associar-se fisicamente e desfosforilar a FoxO1 no fígado, resultando em aumento da gliconeogênese e hiperglicemia na condição de obesidade e diabetes. Por outro lado, o exercício físico é uma da

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Nikkilä, S. (Suvi). "”Ehkä maailmankaikkeus yrittää kertoo mulle, että mää oon oikeessa ammatissa”:MKT-harjoittelun merkitys ammatillisen itseymmärryksen kehittymiselle luokanopettajaopiskelijoiden kertomana." Master's thesis, University of Oulu, 2016. http://urn.fi/URN:NBN:fi:oulu-201606042330.

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Opettajan ammatillinen itseymmärrys tarkoittaa käsitystä itsestä opettajana. Se kuvaa sitä, miten opettaja ymmärtää itsensä suhteessa työhön ja ammatillisuuteen. Ammatillinen itseymmärrys muuttuu uusien kokemusten ja oppimisen myötä. Opettajan vahva ammatillinen itseymmärrys auttaa työssä jaksamisessa sekä oman pedagogisen toiminnan ja valintojen perustelussa. Ammatillinen itseymmärrys kehittyy huomattavasti jo opintojen aikana. Erityisesti opetusharjoitteluissa saadut myönteiset kokemukset tukevat ammatillisen itseymmärryksen kehittymistä opintojen aikana. Jotta opiskelijan ammatillista kehit

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Barbour, Mark J. "The role of map kinase phosphatase 2 (MKP-2) in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis." Thesis, University of Strathclyde, 2015. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25821.

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Experimental Autoimmune Encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS), causing a demyelinating central nervous system (CNS) inflammation which resembles the main pathological features of MS. Mitogen-activated protein kinases (MAPKs), which are key components in the molecular response leading to MS/EAE pathogenesis, are regulated by MAPK phosphatases (MKPs), enzymes which dephosphorylate phosphotyrosine and phosphothreonine residues. It has previously been shown that MKP-2 modulates the inflammatory response during both acute lung injury and sepsis. Therefore in the pres

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Masiero, Massimo. "Induzione della fosfatasi MKP-1 ad opera di NOTCH3: ruolo di questa proteina nell'apoptosi in cellule di leucemia T." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426088.

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T cell acute lymphoblastic leukaemia (T-ALL) is a thymocyte's derived malignant disease characterized by an abnormal lymphoblast numbers that represents 10-15% of all leukaemias in childhood and 25% in adulthood. The Notch pathway has been involved in the pathogenesis of this disease. This is an evolutionary conserved pathway involved not only in leukaemia biology but also in different physiologic processes, including T cell differentiation and angiogenesis. New blood vessels development is mandatory to foster tumor growth, because insufficient perfusion can induce the establishment of a stat

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Haffner, Paula [Verfasser]. "Psychosoziale Funktion bei Menschen mit Bipolaren Störungen: Metakognitives Training (MKT Bipolar) als neue Gruppentherapie und sozialkognitiv-behaviorale Einflussfaktoren / Paula Haffner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/118913862X/34.

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Lloyd, Emma. "Förstelärare i matematik : En kvalitativ intervjustudie om hur förstelärarens arbete i skolämnet matematik kan se ut." Thesis, Karlstads universitet, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-68805.

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Skolverket har skrivit rapporter om förstelärare generellt. Syftet med denna studie var att exemplifiera vad försteläraren i matematik gör och vad det kan medföra, både för kollegor och elever. I studien genomfördes kvalitativa intervjuer med sju förstelärare i matematik vilket synliggjorde exempel på hur förstelärare i matematik arbetar och vad de upplever att det har för effekter. Studiens resultat visade bland annat att det förstelärarna i matematik gör i sitt uppdrag skiljer sig markant. En förstelärare gör i princip ingenting i sitt uppdrag mer än att ha en titel. En annan förstelärare ar

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