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Journal articles on the topic 'Mock circulation loop'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 January 2023

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1

Knierbein, B., H. Reul, R. Eilers, M. Lange, R. Kaufmann, and G. Rau. "Compact Mock Loops of the Systemic and Pulmonary Circulation for Blood Pump Testing." International Journal of Artificial Organs 15, no. 1 (1992): 40–48. http://dx.doi.org/10.1177/039139889201500108.

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Mock loops are an important tool for in vitro investigations of artificial blood pumps. The simple windkessel, throttle, and atrium principle was used for the mock loop design presented. The components of the systemic and the pulmonary mock loop were designed according to calculated numerical simulation parameters. The loops offer a compact design and simple handling. For simulating biventricular assist or total artificial heart (TAH), both loops can be coupled correspondingly. The numerical simulation and the first results with the loops show very good similarity to physiological data of syst

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TAKANO, Tomoya, Toru MASUAWA, and Masahiro OSA. "Mock Circulation Loop for Ventricular Assist Device Evaluation." Proceedings of Ibaraki District Conference 2020.28 (2020): 502. http://dx.doi.org/10.1299/jsmeibaraki.2020.28.502.

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Nestler, Frank, Andrew P. Bradley, Stephen J. Wilson, Daniel L. Timms, O. Howard Frazier, and William E. Cohn. "A Hybrid Mock Circulation Loop for a Total Artificial Heart." Artificial Organs 38, no. 9 (2014): 775–82. http://dx.doi.org/10.1111/aor.12380.

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Li, Xuhui, Zhenfeng Li, and Duanduan Chen. "A mock circulation loop for in vitro haemodynamic evaluation of aorta." Journal of Physics: Conference Series 1600 (July 2020): 012066. http://dx.doi.org/10.1088/1742-6596/1600/1/012066.

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Gräf, Felix, Thomas Finocchiaro, Marco Laumen, Ilona Mager, and Ulrich Steinseifer. "Mock Circulation Loop to Investigate Hemolysis in a Pulsatile Total Artificial Heart." Artificial Organs 39, no. 5 (2015): 416–22. http://dx.doi.org/10.1111/aor.12399.

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Stollenwerk, André, Mateusz Buglowski, and Jan Kühn. "Mock loop for bubble generation in a centrifugal blood pump for fault simulation." Current Directions in Biomedical Engineering 4, no. 1 (2018): 33–36. http://dx.doi.org/10.1515/cdbme-2018-0009.

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AbstractIn extracorporeal blood circulation intensive care treatments, the occurrence of gas within the circulation is one known major hazard. This gas volume can cause severe harm to the patient like infarctions. Consequently, within risk assessment for these treatments gas bubbles are usually addressed by either constructive or signal based approaches. All signal-based approaches do have in common that they need a sufficient amount of data to be parameterized. These data can only be acquired in animal trials or laboratory experiments, as they could result in harm to patients. Hence, we desig

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Salesch, Tobias, Jonas Gesenhues, and Dirk Abel. "A Hybrid Mock Circulation for Control Algorithms of Ventricular Assist Devices." Current Directions in Biomedical Engineering 5, no. 1 (2019): 409–11. http://dx.doi.org/10.1515/cdbme-2019-0103.

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AbstractThis paper deals with the design, simulation and control of a new lightweight hybrid Mock-Loop (MCL) concept. The proof of concept is evaluated by two simulation approaches. First, the design parameters are chosen by an optimal control problem. Second, a cascading controller structure is evaluated in a simulation. Both show that with a suitable range of the design parameter the new lightweight concept can be used as a MCL. To validate these findings, further investigations with the MCL under realistic test conditions are required.

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SUDA, Yoshihiro, Toru MASUZAWA, and Wataru KUROSAKI. "2C03 Relationship between arterial compliance and blood pressure waveform in mock circulation loop." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2013.25 (2013): 317–18. http://dx.doi.org/10.1299/jsmebio.2013.25.317.

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Timms, Daniel L., Shaun D. Gregory, Nicholas A. Greatrex, Mark J. Pearcy, John F. Fraser, and Ulrich Steinseifer. "A Compact Mock Circulation Loop for the In Vitro Testing of Cardiovascular Devices." Artificial Organs 35, no. 4 (2010): 384–91. http://dx.doi.org/10.1111/j.1525-1594.2010.01088.x.

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Gregory, S., D. Timms, M. J. Pearcy, and G. Tansley. "A naturally shaped silicone ventricle evaluated in a mock circulation loop: A preliminary study." Journal of Medical Engineering & Technology 33, no. 3 (2009): 185–91. http://dx.doi.org/10.1080/03091900802184072.

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Timms, Daniel, Mark Hayne, Keith McNeil, and Andrew Galbraith. "A Complete Mock Circulation Loop for the Evaluation of Left, Right, and Biventricular Assist Devices." Artificial Organs 29, no. 7 (2005): 564–72. http://dx.doi.org/10.1111/j.1525-1594.2005.29094.x.

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Lelkes, Peter I., Victor V. Nikolaychik, David A. Meh, et al. "RELIABLE AND SENSITIVE ASSESSMENT OF PLATELET ACTIVATION BY POLYMERIC SURFACES IN A MINIATURIZED MOCK-LOOP CIRCULATION." ASAIO Journal 45, no. 2 (1999): 122. http://dx.doi.org/10.1097/00002480-199903000-00023.

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Timms, Daniel, Mark Hayne, Andy Tan, and Mark Pearcy. "Evaluation of Left Ventricular Assist Device Performance and Hydraulic Force in a Complete Mock Circulation Loop." Artificial Organs 29, no. 7 (2005): 573–80. http://dx.doi.org/10.1111/j.1525-1594.2005.29093.x.

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14

Gehron, Johannes, Julian Zirbes, Markus Bongert, et al. "Development and Validation of a Life-Sized Mock Circulatory Loop of the Human Circulation for Fluid-Mechanical Studies." ASAIO Journal 65, no. 8 (2019): 788–97. http://dx.doi.org/10.1097/mat.0000000000000880.

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Platts, David G., Nicole Bartnikowski, Shaun D. Gregory, Gregory M. Scalia, and John F. Fraser. "Contrast Microsphere Destruction by a Continuous Flow Ventricular Assist Device: An In Vitro Evaluation Using a Mock Circulation Loop." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/4907898.

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Objectives. Transthoracic echocardiography (TTE) is fundamental in managing patients supported with ventricular assist devices (VAD). However imaging can be difficult in these patients. Contrast improves image quality but they are hydrodynamically fragile agents. The aim was to assess contrast concentration following passage through a VAD utilising a mock circulation loop (MCL). Methods. Heartware continuous flow (CF) VAD was incorporated into a MCL. Definity® contrast was infused into the MCL with imaging before and after CF-VAD. 5 mm2 regions of interest were used to obtain signal intensity

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Broda, C., P. A. Smith, Y. Wang, et al. "Hemodynamic Improvement with Application of Mechanical Circulatory Support in Heart Failure with Preserved Ejection Fraction in a Mock Circulation Loop." Journal of Heart and Lung Transplantation 38, no. 4 (2019): S373. http://dx.doi.org/10.1016/j.healun.2019.01.949.

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Das, Arka, Marwan Hameed, Ray Prather, et al. "In-Silico and In-Vitro Analysis of the Novel Hybrid Comprehensive Stage II Operation for Single Ventricle Circulation." Bioengineering 10, no. 2 (2023): 135. http://dx.doi.org/10.3390/bioengineering10020135.

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Single ventricle (SV) anomalies account for one-fourth of all congenital heart disease cases. The existing palliative treatment for this anomaly achieves a survival rate of only 50%. To reduce the trauma associated with surgical management, the hybrid comprehensive stage II (HCSII) operation was designed as an alternative for a select subset of SV patients with the adequate antegrade aortic flow. This study aims to provide better insight into the hemodynamics of HCSII patients utilizing a multiscale Computational Fluid Dynamics (CFD) model and a mock flow loop (MFL). Both 3D-0D loosely coupled

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Das, Arka, Ray Prather, Eduardo Divo, Michael Farias, Alain Kassab, and William DeCampli. "In-Vitro Validation of Self-Powered Fontan Circulation for Treatment of Single Ventricle Anomaly." Fluids 6, no. 11 (2021): 401. http://dx.doi.org/10.3390/fluids6110401.

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Around 8% of all newborns with a Congenital Heart Defect (CHD) have only a single functioning ventricle. The Fontan operation has served as palliation for this anomaly for decades, but the surgery entails multiple complications, and the survival rate is less than 50% by adulthood. A rapidly testable novel alternative is proposed by creating a bifurcating graft, or Injection Jet Shunt (IJS), used to “entrain” the pulmonary flow and thus provide assistance while reducing the caval pressure. A dynamically scaled Mock Flow Loop (MFL) has been configured to validate this hypothesis. Three IJS nozzl

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Broman, Lars Mikael, Lisa Prahl Wittberg, C. Jerker Westlund, et al. "Pressure and flow properties of cannulae for extracorporeal membrane oxygenation II: drainage (venous) cannulae." Perfusion 34, no. 1_suppl (2019): 65–73. http://dx.doi.org/10.1177/0267659119830514.

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The use of extracorporeal life support devices such as extracorporeal membrane oxygenation in adults requires cannulation of the patient’s vessels with comparatively large diameter cannulae to allow circulation of large volumes of blood (>5 L/min). The cannula diameter and length are the major determinants for extracorporeal membrane oxygenation flow. Manufacturing companies present pressure-flow charts for the cannulae; however, these tests are performed with water. Aims of this study were 1. to investigate the specified pressure-flow charts obtained when using human blood as the circulati

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Itkin, George P., Alexander S. Bychnev, Arkady P. Kuleshov, and Alexander A. Drobyshev. "Haemodynamic evaluation of the new pulsatile-flow generation method in vitro." International Journal of Artificial Organs 43, no. 3 (2019): 157–64. http://dx.doi.org/10.1177/0391398819879939.

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Continuous-flow ventricular-assist devices are widely used to support patients with advanced heart failure, because continuous-flow ventricular-assist devices are more durable, have smaller sizes and have better survival rates for patients compared to the pulsatile-flow ventricular-assist devices. Nevertheless, continuous-flow ventricular-assist devices often cause complications such as gastrointestinal bleeding, haemorrhagic stroke, and aortic insufficiency and have a negative impact on the microcirculation for both long-time implantable and short-time extracorporeal systems. The aim of this

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Cabrera Fischer, Edmundo I., Ricardo L. Armentano, Franco M. Pessana, et al. "Endothelium-dependent arterial wall tone elasticity modulated by blood viscosity." American Journal of Physiology-Heart and Circulatory Physiology 282, no. 2 (2002): H389—H394. http://dx.doi.org/10.1152/ajpheart.00330.2001.

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The role of blood viscosity on arterial wall elasticity before and after deendothelization (DE) was studied. Seven ovine brachiocephalic arteries were studied in vitro under physiological pulsatile flow conditions achieved by a mock circulation loop. Instantaneous pressure and diameter signals were assessed in each arterial segment. Incremental elastic modulus ( E inc) was calculated using the slope of the pure elastic stress-strain relationship. There was no significant difference between E inc values before and after DE (3.11 vs. 3.16 107 dyn/cm2) at a blood viscosity of 2.00 mPa · s. Increa

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TANAKA, Yui, Tomotaka MURASHIGE, and Wataru HIJIKATA. "Synchronous Control with Heartbeat in a Magnetically Levitated Centrifugal Blood Pump by Estimating a Pump Flow Rate with a Radial Disturbance Observer–Validation in a Simple Mock Circulation Loop–." Journal of the Japan Society of Applied Electromagnetics and Mechanics 29, no. 1 (2021): 72–77. http://dx.doi.org/10.14243/jsaem.29.72.

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23

Gehron, J., G. Wozniak, F. Dapper, E. Schindler, and F. W. Hehrlein. "Potential problems with simplified selective cerebral perfusion - experimental investigations and clinical improvements." Perfusion 12, no. 6 (1997): 377–83. http://dx.doi.org/10.1177/026765919701200606.

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Currently the most used perfusion techniques during aortic arch surgery to prevent cerebral damage include hypothermic circulatory arrest, retrograde cerebral perfusion and selective cerebral perfusion (SCP). The application of simplified SCP, which does not require deep hypothermia, has become an alternative procedure for brain protection. Including the physiological principle of autoregulated cerebral blood flow, cerebral perfusion flow is not predetermined, but differentiated from the different cannula sizes for the lower and upper body perfusion. In a mock circulation loop, we could show t

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Liu, Guang-Mao, Hai-bo Chen, Jian-feng Hou, Yan Zhang, and Sheng-shou Hu. "Platelet adhesion emulation: A novel method for estimating the device thrombosis potential of a ventricular assist device." International Journal of Artificial Organs 43, no. 4 (2019): 252–57. http://dx.doi.org/10.1177/0391398819885946.

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Device thrombosis inside ventricular assist devices remains a limitation to their long-term clinical use. Thrombosis potential exists in almost all ventricular assist devices because the device-induced high shear stress and vortices can activate platelets, which then aggregate and adhere to the surfaces inside the ventricular assist device. To decrease the device thrombosis potential of long-term use of ventricular assist devices, a methodology entitled platelet adhesion emulation for predicting the thrombosis potential and thrombosis position inside the ventricular assist devices is developed

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Haya, Laura, and Stavros Tavoularis. "Effects of bileaflet mechanical heart valve orientation on fluid stresses and coronary flow." Journal of Fluid Mechanics 806 (September 29, 2016): 129–64. http://dx.doi.org/10.1017/jfm.2016.582.

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The effects of the orientation of a bileaflet mechanical heart valve on the viscous and turbulent stresses in the flow past it and on the flow rate in the right coronary artery were investigatedin vitroin a mock circulation loop, using a fluid that matched the kinematic viscosity of blood and the refractive index of the aorta model. Measurements were made past the valve mounted in three orientations at the base of an anatomical aorta model, within physiological aortic flow conditions. At peak flow, the turbulent stresses were on average 21 % higher and viscous stresses exceeding 10 Pa (namely

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Lipka, Maciej, Anna Talarowska, Grzegorz Wojtania, and Marek Migdal. "Experimental study of ISHTAR thermostatic irradiation device for the MARIA research reactor." EPJ Web of Conferences 253 (2021): 04001. http://dx.doi.org/10.1051/epjconf/202125304001.

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Materials and core components for the next generation power reactors technologies require testing that can be performed in existing research reactors. Such experiments employ devices dedicated to reflect the relevant thermal and neutron parameters simulating conditions present in, for example, but not limited to, HTGR reactors. A novel thermostatic irradiation device named ISHTAR (Irradiation System for High-Temperature Reactors) has been designed and constructed in the MARIA research reactor. Its mission is to enable irradiation of samples in controlled, homogeneous temperature field reaching

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Tozzi, Piergiorgio, Audrey Maertens, Jonathan Emery, Samuel Joseph, Matthias Kirsch, and François Avellan. "An Original Valveless Artificial Heart Providing Pulsatile Flow Tested in Mock Circulatory Loops." International Journal of Artificial Organs 40, no. 12 (2017): 683–89. http://dx.doi.org/10.5301/ijao.5000634.

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Purpose We present the test bench results of a valveless total artificial heart that is potentially compatible with the pediatric population. Methods The RollingHeart is a valveless volumetric pump generating pulsatile flow. It consists of a single spherical cavity divided into 4 chambers by 2 rotating disks. The combined rotations of both disks produce changes in the volumes of the 4 cavities (suction and ejection). The blood enters/exits the spherical cavity through 4 openings that are symmetrical to the fixed rotation axis of the first disk. Mock circulatory system: The device pumps a 37% g

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Andreoli, F., M. Angelone, A. Colangeli, et al. "Comparison between measurement and calculations for a 14 MeV neutron water activation experiment." EPJ Web of Conferences 239 (2020): 21002. http://dx.doi.org/10.1051/epjconf/202023921002.

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The nuclear heat loads due to gamma rays emitted from the decay of 16N and delayed neutrons from17N, generated by the activation of water in cooling circuits, are critical for ITER design. The assessment of nuclear heating from activated water is complex; it requires temporal and spatial dependent transport and activation calculations taking into account variation of irradiation, water flow conditions and cooling circuits’ parameters. A water activation experiment has been recently conducted at the14 MeV Frascati Neutron Generator (FNG) in order to validate the methodology for water activation

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Cappon, Femke, Tingting Wu, Theodore Papaioannou, Xinli Du, Po-Lin Hsu, and Ashraf W. Khir. "Mock circulatory loops used for testing cardiac assist devices: A review of computational and experimental models." International Journal of Artificial Organs 44, no. 11 (2021): 793–806. http://dx.doi.org/10.1177/03913988211045405.

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Heart failure is a major health risk, and with limited availability of donor organs, there is an increasing need for developing cardiac assist devices (CADs). Mock circulatory loops (MCL) are an important in-vitro test platform for CAD’s performance assessment and optimisation. The MCL is a lumped parameter model constructed out of hydraulic and mechanical components aiming to simulate the native cardiovascular system (CVS) as closely as possible. Further development merged MCLs and numerical circulatory models to improve flexibility and accuracy of the system; commonly known as hybrid MCLs. A

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Conijn, Maartje, Lieke Wintermans, Rutger Metselaar, et al. "A 3D printed pulmonary mock loop for hemodynamic studies in congenital heart disease." Biomedical Physics & Engineering Express, August 15, 2022. http://dx.doi.org/10.1088/2057-1976/ac8993.

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Abstract Background With the increasing survival of the congenital heart disease population, there is a growing need for in-depth understanding of blood circulation in these patients. Mock loops provide the opportunity for comprehensive hemodynamic studies without burden and risks for patients. This study aimed to evaluate the ability of the presented mock loop to mimic the hemodynamics of the pulmonary circulation with and without stenosis and the MR compatibility of the system. Methods A pulsatile pump with two chambers, separated by a flexible membrane, was designed and 3D printed. A cough

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Schwärzel, Leonie S., Anna M. Jungmann, Nicole Schmoll, et al. "A mock circulation loop to test extracorporeal CO2 elimination setups." Intensive Care Medicine Experimental 8, no. 1 (2020). http://dx.doi.org/10.1186/s40635-020-00341-z.

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Abstract Background Extracorporeal carbon dioxide removal (ECCO2R) is a promising yet limited researched therapy for hypercapnic respiratory failure in acute respiratory distress syndrome and exacerbated chronic obstructive pulmonary disease. Herein, we describe a new mock circuit that enables experimental ECCO2R research without animal models. In a second step, we use this model to investigate three experimental scenarios of ECCO2R: (I) the influence of hemoglobin concentration on CO2 removal. (II) a potentially portable ECCO2R that uses air instead of oxygen, (III) a low-flow ECCO2R that ach

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Gregory, Shaun D., Jo P. Pauls, Eric L. Wu, et al. "An advanced mock circulation loop for in vitro cardiovascular device evaluation." Artificial Organs 44, no. 6 (2020). http://dx.doi.org/10.1111/aor.13636.

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Holtmannspötter, OAN, T. Finocchiaro, R. Autschbach, and J. Spillner. "Software controlled mock circulation loop for validation of tah and vad controls." Thoracic and Cardiovascular Surgeon 59, S 01 (2011). http://dx.doi.org/10.1055/s-0030-1269268.

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Kado, Yuichiro, Anthony R. Polakowski, Barry D. Kuban, et al. "Left atrial assist device function at various heart rates using a mock circulation loop." International Journal of Artificial Organs, December 1, 2020, 039139882097750. http://dx.doi.org/10.1177/0391398820977508.

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We are developing a new left atrial assist device (LAAD) for patients who have heart failure with preserved ejection fraction (HFpEF). This study aimed to assess the hemodynamic effects of the LAAD under both normal heart conditions and various diastolic heart failure (DHF) conditions using a mock circulatory loop. A continuous-flow pump that simulates LAAD, was placed between the left atrial (LA) reservoir and a pneumatic ventricle that simulated a native left ventricle on a pulsatile mock loop. Normal heart (NH) and mild, moderate, and severe DHF conditions were simulated by adjusting the di

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Lanzarone, Ettore, and Fabrizio Ruggeri. "Inertance Estimation in a Lumped-Parameter Hydraulic Simulator of Human Circulation." Journal of Biomechanical Engineering 135, no. 6 (2013). http://dx.doi.org/10.1115/1.4024138.

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Pulsatile mock loop systems are largely used to investigate the cardiovascular system in vitro. They consist of a pump, which replicates the heart, coupled with a lumped-parameter hydraulic afterload, which simulates vasculature. An accurate dimensioning of components is required for a reliable mimicking of the physiopathological behavior of the system. However, it is not possible to create a component for the afterload inertance, and inertance contributions are present in the entire circuit. Hence, in the literature, inertance is neglected or qualitatively evaluated. In this paper, we propose

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Kumar Radhakrishnan, Pradeep, Gayathri Ananyajyothi Ambat, Pulivarthi Nageshwar Rao, et al. "HYBRID MECHANICAL CIRCULATORY LOOPS – AN EMERGING NEED FOR TOTAL ARTIFICIAL HEARTS WITH NOVEL TECHNOLOGIES." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, May 1, 2022, 44–46. http://dx.doi.org/10.36106/ijsr/5707085.

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Circulatory assist devices need to be tested at various levels prior to human implantation. These include numerical simulations, lab and animal testing, tissue computability prior to human trials that would scale in terms of complexity of indications and participant load. Mock circulatory loops though not ideal offer the best current equivalents of gold standard for such purposes in the in vitro domain. These could be very simple hydraulic loops to complex hydraulic loop interface with computers. These need to replicate both right and left circulatory systems coupled with vascular compliances

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Hildebrand, Stephan, Sascha Groß-Hardt, Thomas Schmitz-Rode, Ulrich Steinseifer, and Sebastian Victor Jansen. "In-vitro performance of a single-chambered total artificial heart in a Fontan circulation." Journal of Artificial Organs, May 6, 2021. http://dx.doi.org/10.1007/s10047-021-01273-5.

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AbstractAn in-vitro study was conducted to investigate the general feasibility of using only one pumping chamber of the SynCardia total artificial heart (TAH) as a replacement of the single ventricle palliated by Fontan circulation. A mock circulation loop was used to mimic a Fontan circulation. The combination of both ventricle sizes (50 and 70 cc) and driver (Freedom Driver and Companion C2 Driver) was investigated. Two clinical relevant scenarios (early Fontan; late Fontan) as derived from literature data were set up in the mock loop. The impact of increased transpulmonary pressure gradient

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Rozencwajg, Sacha, Eric L. Wu, Silver Heinsar, et al. "A mock circulation loop to evaluate differential hypoxemia during peripheral venoarterial extracorporeal membrane oxygenation." Perfusion, January 17, 2022, 026765912110565. http://dx.doi.org/10.1177/02676591211056567.

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Introduction Peripheral veno-arterial extracorporeal membrane oxygenation (VA ECMO) creates a retrograde flow along the aorta competing with the left ventricle (LV) in the so-called ‘mixing zone’ (MZ). Detecting it is essential to understand which of the LV or the ECMO flow perfuses the upper body – particularly the brain and the coronary arteries – in case of differential hypoxemia (DH). Methods We described a mock circulation loop (MCL) that enabled experimental research on DH. We recreated the three clinical situations relevant to clinicians: where the brain is either totally perfused by th

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Rapp, Ethan S., Suraj R. Pawar, Jeffrey R. Gohean, Erik R. Larson, Richard W. Smalling, and Raul G. Longoria. "Estimation of Systemic Vascular Resistance Using Built-In Sensing From an Implanted Left Ventricular Assist Device." Journal of Engineering and Science in Medical Diagnostics and Therapy 2, no. 4 (2019). http://dx.doi.org/10.1115/1.4045204.

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Abstract This paper presents an approach for real-time estimation of the systemic vascular resistance (SVR) of heart failure patients who have a left ventricular assist device (LVAD). Notably, an approach is described that relies only on sensing that is built into the LVAD, so no additional sensors or measurements are required. The estimation of SVR is accomplished using a variant of the extended Kalman filter (EKF) algorithm, making use of a reduced-order systemic circulation model, and requires LVAD flowrate as an input to the systemic circulation and measurement of the LVAD differential pre

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Farag, James, Andrew F. Stephens, W. Juene Chong, Shaun D. Gregory, and Silvana F. Marasco. "Intra-aortic Balloon Pump Use With Extra Corporeal Membrane Oxygenation—A Mock Circulation Loop Study." ASAIO Journal Publish Ahead of Print (August 3, 2021). http://dx.doi.org/10.1097/mat.0000000000001547.

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Chen, Duanduan, Shichao Liang, Zhenfeng Li, et al. "A Mock Circulation Loop for In Vitro Hemodynamic Evaluation of Aorta: Application in Aortic Dissection." Journal of Endovascular Therapy, August 3, 2021, 152660282110348. http://dx.doi.org/10.1177/15266028211034863.

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Purpose Aortic dissection (AD) is a catastrophic disease with complex hemodynamic conditions, however, understandings regarding its perfusion characteristics were not sufficient. In this study, a mock circulation loop (MCL) that integrated the Windkessel element and patient-specific silicone aortic phantoms was proposed to reproduce the aortic flow environment in vitro. Materials and Methods Patient-specific normal and dissected aortic phantoms with 12 branching vessels were established and embedded into this MCL. Velocities for aortic branches based on 20 healthy volunteers were regarded as t

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Zhao, Xiang, Luxiang Zhao, Jian Xu, et al. "Aortic valve opening in mock-loop with continuous-flow left ventricular assist device." International Journal of Artificial Organs, July 11, 2022, 039139882211118. http://dx.doi.org/10.1177/03913988221111811.

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The appropriate opening of aortic valves is crucial for heart failure (HF) patients with left ventricular assist devices (LVADs). Nevertheless, up to the present time, aortic valve monitoring has not been performed in discharged patients. In this study, a mock-loop platform was developed to investigate the aortic valve performance in LVAD patients. An additional sluice valve was placed next to the aortic valve that when the sluice valve is manually closed, the aortic valve will remain closed; when the sluice valve is open, the aortic valve is opened or closed upon the pressures. The results sh

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Mueller, Indra, So-Hyun Jansen-Park, Michael Neidlin, et al. "Design of a right ventricular mock circulation loop as a test bench for right ventricular assist devices." Biomedical Engineering / Biomedizinische Technik 62, no. 2 (2017). http://dx.doi.org/10.1515/bmt-2016-0104.

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AbstractRight heart failure (RHF), e.g. due to pulmonary hypertension (PH), is a serious health issue with growing occurrence and high mortality rate. Limited efficacy of medication in advanced stages of the disease constitutes the need for mechanical circulatory support of the right ventricle (RV). An essential contribution to the process of developing right ventricular assist devices (RVADs) is the

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Liu, Guang-Mao, Fu-Qing Jiang, Xiao-Han Yang, Run-Jie Wei, and Sheng-Shou Hu. "Experimental investigation of the influence of the hydraulic performance of an axial blood pump on intraventricular blood flow." International Journal of Artificial Organs, April 28, 2021, 039139882110130. http://dx.doi.org/10.1177/03913988211013046.

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Blood flow inside the left ventricle (LV) is a concern for blood pump use and contributes to ventricle suction and thromboembolic events. However, few studies have examined blood flow inside the LV after a blood pump was implanted. In this study, in vitro experiments were conducted to emulate the intraventricular blood flow, such as blood flow velocity, the distribution of streamlines, vorticity and the standard deviation of velocity inside the LV during axial blood pump support. A silicone LV reconstructed from computerized tomography (CT) data of a heart failure patient was incorporated into

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Kung, Ethan, Masoud Farahmand, and Akash Gupta. "A Hybrid Experimental-Computational Modeling Framework for Cardiovascular Device Testing." Journal of Biomechanical Engineering 141, no. 5 (2019). http://dx.doi.org/10.1115/1.4042665.

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Significant advances in biomedical science often leverage powerful computational and experimental modeling platforms. We present a framework named physiology simulation coupled experiment (“PSCOPE”) that can capitalize on the strengths of both types of platforms in a single hybrid model. PSCOPE uses an iterative method to couple an in vitro mock circuit to a lumped-parameter numerical simulation of physiology, obtaining closed-loop feedback between the two. We first compared the results of Fontan graft obstruction scenarios modeled using both PSCOPE and an established multiscale computational

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Ise, Hayato, Kyohei Oyama, Shingo Kunioka, et al. "Hypothermic circulatory arrest does not induce coagulopathy in vitro." Journal of Artificial Organs, March 18, 2022. http://dx.doi.org/10.1007/s10047-022-01324-5.

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AbstractHypothermic circulatory arrest (HCA) is an essential procedure during aortic surgery to protect organs; however, hypothermia is believed to cause coagulopathy, which is a major fatal complication. This study aimed to clarify the impact of hypothermia on coagulation by eliminating clinical biases in vitro. In the hypothermic storage study, blood samples from five healthy volunteers were stored at 37 ℃ (group N) for 3 h or at 20 ℃ for 2 h, followed by 1 h of rewarming at 37 ℃ (group H). Thromboelastography was performed before and after 3 h of storage. In the mock circulation loop (MCL)

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Trager, Asher L., Chander Sadasivan, Jaehoon Seong, and Baruch B. Lieber. "Correlation Between Angiographic and Particle Image Velocimetry Quantifications of Flow Diverters in an In Vitro Model of Elastase-Induced Rabbit Aneurysms." Journal of Biomechanical Engineering 131, no. 3 (2009). http://dx.doi.org/10.1115/1.3049528.

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The rupture of a cerebral aneurysm can result in a hemorrhagic stroke. A flow diverter, which is a porous tubular mesh, can be placed across the neck of a cerebral aneurysm to induce the cessation of flow and initiate the formation of an intra-aneurysmal thrombus. By finding a correlation between particle image velocimetry (PIV) and digital subtraction angiography, a better assessment of how well an aneurysm is excluded from the parent artery can be made in the clinical setting. A model of a rabbit elastase-induced aneurysm was connected to a mock circulation loop. The model was then placed un

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Saisho, Hiroyuki, Michael Scharfschwerdt, Tim Schaller, et al. "An ex vivo evaluation of two different suture techniques for the Ozaki aortic neocuspidization procedure." Interactive CardioVascular and Thoracic Surgery, June 5, 2021. http://dx.doi.org/10.1093/icvts/ivab138.

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Abstract OBJECTIVES We investigated the Ozaki procedure using a single interrupted suture technique (SST) and compared this with the standard continuous suture technique (CST) with regard to hydrodynamic valve performance. In addition, both techniques were compared with the native aortic valve (NAV). METHODS Effective orifice area, mean pressure gradient and leakage volume were evaluated in the NAV as well as after an Ozaki procedure using SST or CST in fresh swine aortic roots using a mock circulation loop. The NAV, SST and CST were evaluated under 4 defined hydrodynamic conditions. RESULTS B

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Liang, Shichao, Heyue Jia, Xuehuan Zhang, et al. "In-vitro and In-silico Haemodynamic Analyses of a Novel Embedded Iliac Branch Device." Frontiers in Cardiovascular Medicine 9 (April 5, 2022). http://dx.doi.org/10.3389/fcvm.2022.828910.

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BackgroundIliac branch devices (IBDs) are valid tools for internal iliac artery preservation during endovascular abdominal aortic aneurysm and iliac aneurysm repair. The purpose of this study was to evaluate the effectiveness of a novel IBD with an embedded branch configuration.MethodA typical iliac artery model was reconstructed, and two models were manufactured using three-dimensional printing technology. The novel IBD was deployed into one iliac artery model by an experienced vascular surgeon. A mock circulation loop (MCL) and a computational fluid dynamics (CFD) simulation were used to inv

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Liang, Shichao, Heyue Jia, Huiwu Dong, et al. "Hemodynamic Study of Stanford Type B Aortic Dissection Based on Ex Vivo Porcine Aorta Models." Journal of Endovascular Therapy, March 6, 2022, 152660282210810. http://dx.doi.org/10.1177/15266028221081089.

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Background: In this study, we aimed to evaluate hemodynamic influence of the dissected aortic system via various ex vivo type B aortic dissection (AD) models. Methods: Twenty-four raw porcine aortas were harvested and randomly divided into 4 groups to create various aortic models. Model A was the control group, while models B to D indicated the AD group, where models B and C presented a proximal primary entry with the false lumen (FL) lengths of 15 and 20 cm, respectively, and model D presented a 20 cm FL with a proximal primary entry and a distal reentry. All the aortic models were connected

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