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Arey, Kelly Marie. "Examination of Birth Outcomes with Mode of Delivery for Breech Presentation." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/1686.
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Chou, Chien. "Effects of visual information presentation mode and testing mode on skill analysis training in an interactive video setting /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487682558444435.
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Nagaraj, Sanjay. "The impact of consumer knowledge, information mode and presentation form on advertising effects." Doctoral thesis, KTH, Numerisk Analys och Datalogi, NADA, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4387.
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Consumers consistently acquire information on product attributes available to them. In considering the many and varied effects of advertising a very central issue is how these attribute information in an ad is processed, that is, how consumers were able to comprehend and remember what an ad claimed. Researchers also seem to believe that the use of persuasive ads increases recall of attribute information, enhances attitude toward the ad, brand, and positively affects intent to purchase. Such information in marketing communications is often presented either in a vivid or non-vivid form and they are conveyed in either numbers or adjectives. The complexity of numerical information and the fact that they are being used on a frequent basis to make many important decisions makes numerical cognition a challenging and important domain for this research. In this research we draw the reviews and advances in consumer research on comparisons between two types of information in an advertising setting and combining it along with two types of presentation forms. Yet a few empirical investigations of presentation forms, typically vividness and its interaction effects with information mode, have been conducted in a consumer-behavior context. Further to add to this research is the inclusion of consumer knowledge moderates the way such information is processed. Although the effects of vividness in terms of its ability to impart a persuasive communication have yielded mixed results, we extend the scope of vividness research and attempt to examine vividness effects and its interaction with information mode in print ads. Since different consumers use different skills and strategies to evaluate information, it is suggested that individual differences in product knowledge may be an important moderating factor in information processing and final response to product ads. In order to address the research issues, a conceptual framework based on the availability valence hypothesis (availability theory) was created. Sixty individual hypotheses were the resulting derivatives from the framework. To test the hypotheses and the conceptual model, a 2x2x2 factorial design was employed and examined responses from 160 students from both arts and computing science program of a major university. Experiments examined the persuasive impact of a new brand containing two forms of presentation and information mode. The conclusions from the study reveal that vividness has an impact on recall and attitudes. The impact on recall and judgment was more pronounced for novices in comparison to experts. The interactions between presentation form and information mode also revealed that the consumer knowledge moderates the way information is processed for recall and subsequent judgment. Experts were able to able to recall attribute information more accurately than novices irrespective of the presentation form and the judgment imparted was based on the information available. All functional properties of the variables in the proposed model had an impact on the effects of advertising during memory and judgment tasks. We also provided a theoretical rationale based on extant literature on the availability model as to which presentation form and information mode may influence the recall and judgment resulting in intent to purchase. The presentation form and information mode highlights the similarities in the benefits offered by an existing base brand. Theoretical and practical implications of the results are discussed as well as the limitations and future directions of this study.QC 20100811
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Hyman, Jarrod D. "Effects of mode of presentation on the influence of source characteristics on persuasion." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/4217.
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Thesis (Ph. D.) -- University of Maryland, College Park, 2006.Thesis research directed by: Psychology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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MOLIN, FRANCK. "Dysfonction sinusale chez le greffe cardiaque : presentation d'un nouveau mode de stimulation definitive." Lille 2, 1991. http://www.theses.fr/1991LIL2M081.
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Agresti, Albert A. "Effects of mode of presentation on head injured patients' recall of narrative information /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266691094183.
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Brattos, Alexandra. "The Effect of Stress Presentation Mode on Stress Acquisition Among Advanced Learners of Russian." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3140.
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The purpose of this research was to test the effect of stress presentation mode on stress acquisition of advanced learners of Russian. The study attempted to determine if advanced learners of Russian are able to place stress more correctly on words in specific texts after receiving various treatments or receiving no treatment. Participants were Brigham Young University students studying Russian as a second language at the third-year level or higher. They were randomly assigned into three groups: a group that received no treatment, a treatment group that read words with graphically marked stress, and a treatment group that heard texts read by a native speaker. All participants completed a pretest, a treatment (in the second and third groups), and a posttest. The pretest and the posttest consisted of a reading task: the participants read 12 sentences taken from 12 different texts. The same words from the texts were used in the treatment to expose the participants to the sentences again in order to determine if the treatment made a difference in the acquisition of correct stress. The treatment was different for each group. Group 1 (A) read texts marked with stress, Group 2 (B) read the same texts but without stress marked; rather, they heard a native speaker of Russian read the texts on a recording, and Group 3 (C) read the same texts but without stress marked graphically or hearing a native speaker. The results of the research reject the hypothesis that aural presentation of stress as opposed to a visual only presentation leads to improved acquisition of stress. However, based on the analyses of the data, overall findings rendered some interesting and unexpected results and observations. First, although the treatment for group A appears to be more effective than that for groups B and C, all groups showed improvement after completing the treatment. This strongly suggests that reading, whatever form it takes, can be a useful tool in facilitating control of stress. Second, group A had more participants that fell into the "fast" reading category, and fast readers scored significantly higher than slow or medium speed readers. This suggests that the faster one reads the better one controls stress, or the better one controls stress the faster one reads.
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Fishfader, Vicki Lynn. "Evidential and extralegal factors in jury verdicts: Presentation mode, retention, and level of emotionality." Scholarly Commons, 1994. https://scholarlycommons.pacific.edu/uop_etds/2774.
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It is becoming commonplace for video technology of various forms to be utilized in modern courtrooms. However, little research exists on how the use of videos in the courtroom influences jury decision making. Studies on this topic could lead to greater understanding of the mechanisms by which jurors arrive at their decisions. For example, jurors are instructed not to let emotional factors impact their decisions, yet attorneys often appeal to a juror's conscience rather than his or her intellect in trying to win a case.
In order to examine these issues, the present study attempted to answer two main questions. First, does video footage influence jurors more than traditional oral testimony? Second, if video evidence does have a strong impact on juror decisions, what are the mechanisms by which this occurs? Participants examined actual materials from a civil case presented in one of three formats: print (transcripts), traditional oral testimony, or traditional testimony plus audiovisual recreation. They were given the Profile of Mood States (POMS) as a pre-and post-test measure of emotional state. Furthermore, they were tested on retention of factual material and asked to designate damage awards as well as responsibility levels of both the plaintiff and defendant in the case. Results indicated that a number of changes in mood state occurred following stimulus presentation, regardless of the stimulus presentation mode or gender of the subject. The five POMS scales on which this pattern appeared were the Depression-Dejection scale, the Fatigue-Inertia scale, the Anger-Hostility scale, the Vigor-Activity scale, and the Total Mood Disturbance scale.
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Daniels, Harold Lee. "Interaction of Cognitive Style and Learner Control of Presentation Mode in a Hypermedia Environment." Diss., Virginia Tech, 1996. http://hdl.handle.net/10919/30394.
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Educational hypermedia has been heralded as providing instruction that accommodates learners' individual differences, allowing them to learn in accordance with their unique needs, desires, and preferences. Advocates of hypermedia point to learner control, multimedia capability, and parallels to theories of human memory as evidence for educational hypermedia1s efficacy. While intuitively appealing, empirical research has not confirmed (or rejected) this assumption. Nor is there compelling evidence to suggest that learners who posses different cognitive styles benefit equally from educational hypermedia environments.
This study reports on an examination of cognitive style field dependence/independence and learner control of presentation mode within an educational hypermedia environment. Participants were 122 high school juniors and seniors enrolled in classes whose curricula dealt with the political process. The experimental sites were three high schools located in North Carolina, Virginia, and West Virginia. Learners classified as field dependent and field independent were asked to explore a commercial hypermedia program concerning the presidential primary election process. Participants were randomly assigned to one of two versions of the program, a control group which utilized the commercially designed multimedia presentations and a treatment group that offered the choice of single-channel presentations in addition to the multiple-channel presentations.
After interacting with the program participants completed a ten item post test consisting of five recall and five problem-solving questions. Their actions within the hypermedia environment were automatically tracked by the computer. Data analysis consisted of a 3 x 2 ANOVA to examine interaction between field dependency and learner control of presentation mode as measured by the post test. Field dependency was correlated with frequency of multiple-channel selections. A secondary analysis examined main effects and interactions on the recall and problem-solving questions separately utilizing a 3 x 2 ANOVA.
Data analysis revealed no correlation between field dependency and frequency of multimedia selections. The study found no significant interaction between field dependency and control (program or learner) of presentation mode as measured by the ten item post test. Separate analysis of the recall and problem-solving questions also revealed no significant interaction.Ph. D.
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Reardon, Linda Brown. "The effects of presentation mode and cognitive style on immediate recall of map information." Diss., Virginia Polytechnic Institute and State University, 1987. http://hdl.handle.net/10919/49873.
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This study investigated the use of varying formats for presenting complex visual information in the form of fictitious maps. There were three treatment formats, two which sequenced the map information by conceptual category (i.e., roads, geographic features, boundaries), and a third which used a normal intact map format. The two sequenced presentations differed in that the first was additive; that is, each visual in the sequence built upon the preceding one by adding a category of information until the complete map was displayed. The second simply displayed one conceptual category per visual.
The cognitive style field dependence-independence was also examined as potentially related to map-learning ability based on the greater cognitive restructuring ability of the field independent orientation. lt was predicted that the achievement of field-dependent students would be higher with the sequenced map treatments, and the achievement of the field-independent students would be higher with the intact map treatment. The research questions were:
1. Does dividing map information into either an Additive sequence or a Part-by-Part sequence affect performance on a map-learning task?
2. Do students classified as held dependent, moderately field - independent, or held independent differ in their performance on a map-learning task?
3. Is there an interaction across visual design format with cognitive style?
The sample for this study was composed of 92 four-year college students. Level of held dependence was measured by the GEFT. The analysis of the 3 X 3 research design was by a two-way analysis of variance with posttest scores (which measured immediate recall of map information) as the dependent variable. Map presentation format and cognitive style were independent variables. Results indicated there was no difference in achievement among the three map presentation formats, but that cognitive style was significantly related to posttest scores; that is, a higher level of held independence was associated with more effective map-learning performance.Ed. D.
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Velayo, Richard S. "Retention of content material as a function of mode of presentation and preconceived degree of difficulty." Scholarly Commons, 1988. https://scholarlycommons.pacific.edu/uop_etds/2167.
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The effects of the mode of presentation and the preconceived degree of difficulty on the retention of academic content material were measured. The design of the experiment was a 6 x 3 x 2 split-plot factorial. The levels for the mode of presentation were: (a) print-only, (b) pictorial-plus-print, (c) audio only, (d) pictorial-plus-audio, (e) print-plus-audio, and (f) pictorial-plus-print-plus-audio. The levels for the preconceived degree of difficulty were: (a) very easy, (b) neutral, and (c) very difficult. The participants were 112 undergraduate students (24 males, 88 females) randomly assigned to the experimental conditions. The dependent variables were the immediate and delayed retention of content material measured through the use of four criterion tests: a drawing test, an identification test, a terminology test, and a comprehension test. Results for the univariate split-plot ANOVA of the total scores showed that the main effects of mode and preconceived degree of difficulty were found to be significant. All four predicted differences between means were not statistically significant. Only one of the three hypotheses of no significant difference was supported--the hypothesis of no significant difference between the pictorial-plus-print-plus-audio condition and the pictorial-plus-audio condition. No significant mean differences between the easy, neutral, and difficult conditions were found, although there was a significant main effect and the means for these conditions were ordered such that the more difficult the content material was perceived, the lesser was the ability to retain such material. Multivariate analysis of the immediate and delayed tests showed that the major factors contributing to the significant effect of mode were the drawing and identification tests, but subsequent multiple comparison tests did not show significant support for any predictions. For the identification test, a significant main effect for mode showed that the pictorial-plus-audio and pictorial-plus-print-plus audio means were significantly superior to the audio only mean.
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Garatti, Marinetta. "The role of syntax presentation mode, abstract reasoning, and learned instructional preference on second language achievement." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu1250536529.
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Garatti, Marinella. "The role of syntax presentation mode, abstract reasoning, and learner instructional preference on second language achievement /." The Ohio State University, 1999. http://rave.ohiolink.edu/etdc/view?acc_num=osu148818704953809.
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Childers, Chadwick T. "Instrument choice of fifth grade boys and girls aural and visual preference based on presentation mode." FIU Digital Commons, 2004. http://digitalcommons.fiu.edu/etd/2331.
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The general purpose of this research was to determine if a lesson including gender will influence the instrument selection process of fifth grade children. Subjects were two homogeneous groups of fifth grade students from Miami, Florida. Each group received a lesson concerning five acoustic musical instruments: the clarinet, flute, saxophone, trumpet, and drums with photos and music excerpts.
The control group did not receive a gender lecture nor did the photographs depict anyone playing the instrument. Overwhelmingly, drums were the instrument of choice in both groups. As a result a second experiment was designed to replicate experiment 1, but drums were removed from the choices and the trombone was substituted as a "male' instrument.
It was concluded that gender did have an effect on the instrument selection process in young children.
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Fitzpatrick, Dale Mary. "The effects of visual format and mode of presentation on nonnative speaker comprehension of verbal information." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/28223.
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The purpose of this study was to gather data on nonnative speakers' comprehension of spoken language presented via the audio mode (sound only) or the video mode (sound + picture). More specifically, the research examined the effects of three visual formats (or picture content)--contained in the video channel—on comprehension of verbal information carried in the audio channel of broadcast news stories. The three visual formats under investigation were: (1) high redundancy (HR): voice-over-film with similar verbal and visual content; (2) low redundancy (LR): voice-over-film with dissimilar verbal and visual content, and (3) talking head: newscaster only presentation, without film. A smaller follow-up study examined the effect of visuals with a group of subjects of higher second-language proficiency.
The procedure utilized a between-and-within-subjects design and nine news stories videotaped from CBC television, categorized according to visual
format. Stimulus news stories were presented to subjects via either the video or audio mode. After each story, actual comprehension o£ verbal information was measured using a test of cued-recall and perceived language comprehension was measured using a self-reporting question. In the video mode, subjects were also asked to rate the difficulty of each story.
The results of an analysis of variance indicated that, under the conditions of the present study, subjects scored significantly higher on a test o£ cued recall when news stories were presented via the video mode. Significant differences were also found between language comprehension scores for each of the visual formats. Highest scores were obtained for the HR stories, and lowest scores for the TH stories. From the results of the follow-up study, it appears the comprehension-facilitating effect of visuals is not as strong for subjects of higher proficiency.
Results are discussed in light of literature on media and learning, the relationship between aural and visual channels, visual format effects and television news, listening comprehension, and visual information processing. Implications and suggestions for further study are presented.Education, Faculty of
Language and Literacy Education (LLED), Department of
Graduate
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Reddan, James Michael. "Effects of presentation mode on community college students' perception of performance quality and self-reported level of musical engagement." Thesis, Boston University, 2014. https://hdl.handle.net/2144/11030.
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Thesis (D.M.A.)--Boston UniversityThe purpose of this study was to examine the effect of presentation mode on community college students' ratings of a choral performance and self-perceived level of engagement with the music controlling for age, gender, and previous musical training. The following research questions were explored: (a) what effect, if any, does presentation mode have on participants' ratings of the quality of a choral performance; (b) what effect,if any, does participants' age, gender, or previous musical training have on participants' ratings of the quality of a choral performance; (c) what effect, if any, does presentation mode have on participants' ratings of their engagement with the music during a choral performance; (d) what effect, if any, does participants' age, gender, or previous musical training have on participants' ratings of their engagement with the music during a choral performance; (e) why do participants rate the quality of a choral performance of one presentation mode higher than others, if at all; and (f) why do different presentation modes make participants feel more or less engaged with the music, if at all. Community college students (N = 71) enrolled in four music appreciation courses at two community colleges rated their perceptions of the performance quality and their level of engagement with the music on four-point Likert-type scale for three presentation modes. Participants provided written responses explaining their ratings. Quality and engagement ratings were analyzed using a three-way repeated measures MANCOV A controlling for age, gender, and years of training. Results indicated that presentation mode was a significant predictor of participants' ratings of quality (p < .001) and level of engagement (p < .001). There was a significant within-subjects effect (p < .05) for age and quality, and between-subjects effect (p < .05) for years of training and engagement. Qualitative data were analyzed, coded, and themes were identified. Themes included focus of attention, environmental factors, technology, and preference affected perceptions of quality. Technology and perception of performance quality affected level of engagement. It was concluded that the presentation mode used to present a listening experience to community college students had a significant effect on students' perceptions of performance quality and level of engagement with music during a listening experience. Moreover, students' perceptions of quality and engagement were most often related to a variety of factors the influenced their focus of attention during the listening experience.
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Bradley, Radakovich Kristy A. "The effects of presentation mode and pace on learning immunology with computer simulation a cognitive evaluation of a multimedia learning resource." Doctoral diss., University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4742.
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Multimedia learning tools have the potential to benefit instructors and learners as supplemental learning materials. However, when such tools are designed inappropriately, this can increase cognitive taxation and impede learning, rendering the tools ineffective. Guided by the theoretical underpinnings provided by cognitive load theory and the cognitive theory of multimedia learning, this study sought to empirically evaluate the effectiveness of a multimedia simulation tool aimed at teaching immunology to novices in an instructional setting. The instructional mode and pace of the tool were manipulated, the three levels of each variable yielding nine experimental groups. The effects of mode and pace on workload and learning scores were observed. The results of this study did not support the theory-driven hypotheses. No significant learning gains were found between the configuration groups, however overall significant learning gains were subsequently found when disregarding mode and pace configuration. Pace was found to influence workload such that fast pace presentations significantly increased workload ratings and a significant interaction of mode and pace was found for workload ratings. The findings suggest that the learning material was too high in intrinsic load and the working memory of the learners too highly taxed for the benefits of applying the design principles to be observed. Results also illustrate a potential exception to the conditions of the design principles when complex terminology is to be presented. Workload findings interpreted in the context of stress adaptation potentially indicate points at which learners at maximum capacity begin to exhibit performance decrements.ID: 030646246; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (Ph.D.)--University of Central Florida, 2011.; Includes bibliographical references (p. 120-126).
Ph.D.
Doctorate
Psychology
Sciences
Modeling and Simulation
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Awad-Elkarim, Ahmed Awad-Elkarim. "Effects of age, gender, ethnicity and social deprivation on mode of presentation, management patterns and outcomes in patients admitted with acute coronary syndromes." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582638.
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Aims: To examine whether level of social deprivation explains the observed inter-ethnic differential in risk of acute coronary syndrome (ACS) admission, and to describe determinants and outcomes of different management patterns stratified by ethnicity. Methods: A prospective registry of consecutive patients admitted to coronary care units and medical wards of eight adjacent west London hospitals. A total of 512 patients with a diagnosis of ACS were admitted between 1 June and 31 August 1998. Level of social deprivation derived from area of residence was used to stratify cases socio-economic status, and the admitted cohort of 428 resident patients was then followed up for 45 months.
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Adel-Patient, Karine. "Evaluation de la reponse immunitaire a un allergene alimentaire, la beta-lactoglobuline bovine, chez la souris dans un modele experimental de sensibilisation : influence du mode de presentation de l'allergene sur la polarisation de la reponse." Paris 5, 1999. http://www.theses.fr/1999PA05N127.
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Ronestjärna, Jonathan. "Presentation av underhållsföreskrifter med modellbaserat konstruktionsunderlag." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-69295.
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Detta examensarbete utfördes på Saab AB, Support & Service, i Tannefors, Linköping, samt vid Institutionen för datavetenskap på Linköpings universitet. Ett moment i kvalitetsarbetet för komplexa industriprodukter, som till exempel flygplan, är att skifta från tvådimensionellt konstruktionsunderlag till tredimensionellt. Tredimensionella modeller har funnits i flera år. Nackdelen med dessa modeller är att de inte kunnat bära någon extra information, förutom den information som krävs för att de ska vara uppritade. Tekniken har gått framåt och nu går det att lagra teknikinformation i modellerna samt göra simuleringar som inte gått att göra förut. I och med att teknikinformation finns i modellerna, går det även att använda denna information till de olika publikationer som skrivs. Syftet med denna studie är att analysera hur teknikinformationsflödet mellan modeller och användare kan komma att se ut vid användning av modellbaserat konstruktionsunderlag, samt att föreslå exempel på hur tekniska publikationer för Gripen NG kan komma att se ut i framtiden. När all information finns i modellen, behövs inte lika mycket personal som redigerar bilder eller skriver text. Detta kommer innebära ekonomisk vinst och efter ett tags användning, kommer det även ge en ytterligare ekonomisk vinst, eftersom användarna har lärt sig hur produkten fungerar och på så sätt blivit effektivare på att använda den än de nuvarande dokumenten.This thesis was carried out at Saab AB, Support & Service, in Tannefors, Linköping, and at the Department of Computer Science at Linköping University. One item in the quality work for complex industrial products, such as aircrafts, is to shift from two-dimensional design data to three-dimensional. Three-dimensional models have been around for years. The disadvantage of these models is that they could not carry any extra information, in addition to the information necessary for them to be plotted. The technology has moved on and now it is possible to store technical information in the models and do simulations that didn't work before. As the technical information is contained in the models, you can also use this information to the various publications that are printed. The purpose of this study is to analyze how the technical information flow between models and users, and also to propose examples of how technical publications for the Gripen NG may be in the future when using model-based design documents. Once all information is in the model, it is not needed to have as much staff employed for editing pictures or writing text. This will involve a financial gain, and after some time, it will also provide an additional financial benefit, because the users have learned how the product works and will be more efficient in using it than the current documents.
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Phillips, Kaitlyn, Brooks B. Pond, Hannah Oakes, and David R. McWethy. "The Influence of Long-Term Ritalin Exposure in a Female Model of Parkinson's Disease." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/13.
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Attention deficit hyperactivity disorder (ADHD) is a commonly diagnosed disorder in children. Methylphenidate (MPH) or Ritalin, is a psychostimulant widely prescribed to treat ADHD from childhood to adulthood. Although patients take MPH for years, studies investigating long-term MPH use are lacking. Additionally, abuse of MPH is a growing problem in young adults. MPH blocks dopamine and norepinephrine transporters, which extends these neurotransmitters’ actions by preventing their reuptake from the cleft. Previous research has shown that long-term exposure to MPH causes dopamine-releasing neurons in the nigrostriatal pathway to become more susceptible to the Parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Here, the mechanism by which MPH sensitizes neurons to MPTP in a female model was investigated. The hypothesis was that oxidation of excess dopamine to a quinone causes neurons within this pathway to become more susceptible to MPTP. This dopamine quinone may be conjugated by the antioxidant glutathione (GSH); however, with an excess of dopamine and therefore quinones, GSH levels will become depleted. Without protection from GSH, quinones may lead to production of highly reactive free radicals, precipitating cell death. Estrogen is thought to be neuroprotective to MPTP, so it was further hypothesized that anestrus (low estrogen) females will show more dopamine cell loss, more quinone production, and more GSH depletion than proestrus (high estrogen) females. To test this hypothesis, MPTP-resistant adolescent female Swiss-Webster mice were divided into 3 treatment groups: saline (control), 1 mg/kg MPH (therapeutic dose), or 10 mg/kg (abusive dose). Within each group, mice were divided into proestrus and anestrus subgroups. All mice were injected twice daily with MPH or saline. After 12 weeks of injections followed by a 7 day washout period, half of each grouping received MPTP injections (4 x 20 mg/kg every 2 hours), while the other half received 4 injections of sterile saline. Mice were sacrificed either 3 or 7 days post-MPTP or saline injection. The substantia nigra and striatum of the nigrostriatal pathway that are affected by Parkinson’s disease were collected. Proestrus females in the saline group showed a significant (pmore dopamine quinone production (*p
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LeBlanc, Vincent. "A Cognitive Model of the Same-Different Task Based on the Inhibition of "Different" Answers." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38461.
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“[The] sense of sameness is the very keel and backbone of our thinking” (James, 1890). To make sense of the ever-shifting information in our environment, we constantly assess whether the world around us changes or not, if objects are the “same” or if they are “different”. This basic decision-making process is found from the lowest level of cognition (e.g. when contrasts are encoded by the retina), to the highest (e.g. when comparing concepts), and anywhere in between. In an experimental context, this process is studied with the “same-different” task, where subjects are asked if two stimuli presented sequentially are strictly identical or not. This experiment has been documented since the 1960s and its results have been replicated with diverse stimuli types (letters, shapes, faces, words, etc.). However, every attempt to model the subjects’ accuracy and response times on correct and incorrect answers simultaneously was unsuccessful so far. Part of the challenge in explaining this task is that “same” answers are faster than expected compared to “different” answers, a phenomenon called the “fast-same effect”.
This thesis aims to assess whether a formal model based on the inhibition of “different” answers is plausible, effectively changing the problem from “fast-same” to “slow-different”. In the first chapter, I review the previous theories and models of the same-different task to learn why they failed. By elimination process, I identify the only cognitive architecture that seems congruent with the data. I then propose a model prototype based on the inhibition of “different” answers that implements this architecture. In the second chapter, I test this prototype with an experimental paradigm designed specifically to assess its plausibility. I conclude that resources should be spent in developing a formal model based on the inhibition of “different” answers, as the prototype’s qualitative predictions are confirmed by both the typical same-different data and the newly acquired data.
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Coleman, Joshua B., Wesley Drew Gill, Allee C. Maxwell, and Russell W. Brown. "Analysis of a Poly(ADP-ribose) Polymerase (PARP) Inhibitor in a Treatment-resistant Depression Model in the Rat." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/53.
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Over 16 million people in the US suffer from major depressive disorder (MDD) each year. Approximately 1/3rd of MDD patients (~5 million) obtain only partial remission or no benefit after trials with multiple drugs or drug combinations. Recently, Ordway and colleagues have reportedelevated levels of DNA oxidation and upregulated gene expression of the base excision repair enzyme poly(ADP-ribose) polymerase-1 (PARP1) in postmortem brain from donors who had MDD at the time of death, as compared to age-matched psychiatrically normal control donors. This study was designed to test whether an inhibitor of PARP, 3-aminobenzamide (3-AB), may be effective to alleviate depressive-like behaviors in a rodent model of treatment-resistant depression. Male rats were ip administered lipopolysaccharide (LPS;100ug/kg) daily for 28 days, and administered a chronic unpredictable stressor on each day. All rats were also administered saline, 3-AB (40 mg/kg), or the serotonin-reuptake inhibitor (SSRI) fluoxetine (trade name: Prozac; 10 mg/kg) on each day, approximately 30 min after LPS treatment. During the 28 day period of LPS treatment, animals were behaviorally tested 5 times on sucrose preference (a test of anhedonia). At the end of the 28 day period, rats were behaviorally tested on a test of acute stress, the Porsolt swim test. Results revealed that 3-AB alleviated anhedonia and the response to acute stress in the Porsolt swim test superior to the fluoxetine group, demonstrating the utility of a PARP inhibitor to alleviate depressive-like behavior in this model. In addition, fluoxetine produced a loss of weight which recovered over days, but not to control levels, and 3-AB did not produce this effect. This study shows that PARP inhibitors may be effective in treatment-resistant depression.
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Stiller, Klaus Dieter. "Computerised multimedia learning modes of text presentation and access to text." Hamburg Kovač, 2006. http://www.verlagdrkovac.de/978-3-8300-2775-1.htm.
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Stiller, Klaus Dieter. "Computerised multimedia learning : modes of text presentation and access to text /." Hamburg : Kovač, 2007. http://www.verlagdrkovac.de/978-3-8300-2775-1.htm.
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Duan, Dandi. "Evaluating the Effectiveness of Multiple Presentations for Open Student Model in EER-Tutor." Thesis, University of Canterbury. Computer Science and Software Engineering, 2009. http://hdl.handle.net/10092/3554.
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As one of the central problems in the area of Intelligent Tutoring Systems (ITSs), student modelling has been widely used to assist in systems’ decision making and students’ learning. On the one hand, by reasoning about students’ knowledge in the instructional domain, a system is able to adapt its pedagogical actions in order to provide a customized learning environment. These actions may include individualized problem-selection, tailored instructions and feedback, as well as updating the presentation of student models. On the other hand, students can reflect on their own learning progress by viewing individual Open Student Models (OSMs) and enhance their meta-cognitive skills by learning from the system’s estimation of their knowledge levels. It is believed that making the information in the student model available to students can raise students’ awareness of their strengths and weaknesses in the corresponding domain and hence allow them to develop a more effective and efficient way of learning.
An OSM has been developed in EER-Tutor. EER-Tutor is a web-enhanced ITS that supports university students in learning conceptual database modelling. Students design Enhanced Entity-Relationship (EER) diagrams and receive different level of feedback in a problem-solving environment. The pedagogical decisions on feedback generation and problem selection are made according to student models. Previously, student models in EER-Tutor are presented to students on request as skill meters. Skill meters have been proved useful in helping students to improve their meta-cognitive skills. However, as the simplest presentation of a student model, skill meters contain very limited information. Some studies show that an OSM with multiple views is more effective since it supports individual preferences and different educational purposes.
The focus of our work is to develop a variety of presentations for the OSM in EER-Tutor. For this purposes, we have modified the system to include not only skill
meters but also other presentation styles. An evaluation study has been performed after the development. Both subjective and objective results have been collected. This thesis presents the extended EER-Tutor, followed by the analysis of the evaluation study.
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Valeiras, Jurado Julia. "A multimodal apprach to persuasion in oral presentations: The case of conference presentations, research dissemination talks and product pitches." Doctoral thesis, Universitat Jaume I, 2017. http://hdl.handle.net/10803/404052.
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Esta tesis presenta un estudio multimodal y etnográfico del uso de estrategias persuasivas en tres géneros orales: presentaciones en conferencias, charlas de divulgación científica, y presentaciones de productos. Estos géneros comparten un importante componente persuasivo: los tres se dirigen a una audiencia tratando de convencerles del valor de un producto, servicio, o investigación. Sin embargo, se usan en dos contextos profesionales diferentes: el académico y el económico, por lo que cabe esperar que consigan su propósito comunicativo de forma diferente. Por otra parte, recientes estudios muestran como distintos discursos, tienden a adoptar cada vez más rasgos promocionales (promocionalización del discurso). En vista de ello, es factible establecer como hipótesis que los tres géneros están relacionados interdiscursivamente, y un estudio multimodal y etnográfico del uso de la persuasión en dichos géneros puede ayudar a clarificar las relaciones existentes entre ellos, así como sus diferencias.This thesis is a multimodal and ethnographic study of the use of persuasive strategies in three oral genres conference presentations, research dissemination talks and product pitches. These presentations share a strong persuasive component in their communicative purpose: the three of them address an audience to convince them of the value of a product, a service or a piece of research. However, they are used in business and academia by different discourse communities in different contexts, and therefore they can be expected to achieve their communicative goals in different ways. In addition, research suggests that there is a trend towards promotionalization of different discourses, among which academic discourse is included. In view of this, I hypothesize that these three genres are intertextually and interdiscursively related, and that a multimodal and ethnographic study of the use of persuasion in them can help to shed some light on these relationships and differences.
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Faheem, Muhammad. "A GUI for online presentation of steel and steelmaking ladle temperature data and simulation." Thesis, Högskolan Dalarna, Elektroteknik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:du-4256.
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Continuous casting is a casting process that produces steel slabs in a continuous manner with steel being poured at the top of the caster and a steel strand emerging from the mould below. Molten steel is transferred from the AOD converter to the caster using a ladle. The ladle is designed to be strong and insulated. Complete insulation is never achieved. Some of the heat is lost to the refractories by convection and conduction. Heat losses by radiation also occur. It is important to know the temperature of the melt during the process. For this reason, an online model was previously developed to simulate the steel and ladle wall temperatures during the ladle cycle. The model was developed as an ODE based model using grey box modeling technique. The model’s performance was acceptable and needed to be presented in a user friendly way. The aim of this thesis work was basically to design a GUI that presents steel and ladle wall temperatures calculated by the model and also allow the user to make adjustments to the model. This thesis work also discusses the sensitivity analysis of different parameters involved and their effects on different temperature estimations.
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Kadleček, Tomáš. "Model elektronického obchodu firmy." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2008. http://www.nusl.cz/ntk/nusl-221697.
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The thesis focuses on questions dealing with a model project of a company e-shop. The work analyses the use of the company e-shop and it contains an analysis of a particular company, theoretical data and possible solutions.
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Chen, Minchu. "Enhancement of presentation of Chinese narrative poems--using a multimedia model for 'Mulan Shih'." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004374.
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Lee, Larry Dee. "An investigation on computer-based instructional presentation modes and perceptual learning styles in concept learning /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.
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Herd, Jane Emma. "Understanding hard to reach adolescents : a bio-psycho-social model of aetiology, presentation and intervention." Thesis, University of East London, 2014. http://roar.uel.ac.uk/4264/.
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This thesis examines hard to reach adolescents in respect of; the link between historical, contextual and familial factors, the young people’s inner working model and the manner of intervention with such young people and how one might understand what is most helpful. Psycho-social case work with seven Black and Minority Ethnic (BME) adolescent boys in an area of high social deprivation and ethnographic study of the direct and wider environment was undertaken. This environment of trauma organised systems, within a community dominated by gang violence was impactful on the whole project. The data was analysed by means of a case study approach using psychodynamic, attachment and neurodevelopmental paradigms. The findings suggest that early and ongoing adverse relational and attachment experiences impacts on four aspects of ‘hard to reachness’: Biological, Unconscious, Relational and Environmental. This includes neurochemical disregulation, excessive use of projective processes, emotional immaturity, difficulties with reciprocity and taking responsibility. The four aspects of ‘hard to reachness’ correspond to four domains of intervention: Management and Safety, Therapeutic, Relationship and Social/External. The relationship is seen as central to successful intervention and the worker needs to be able to move between domains as required. Three groupings of presentations were identified; Chameleons, Reactors and Fragmentors based on neurodevelopmental arousal states, types of projective process and attachment styles. Reactors were seen to be typical of the hard to reach group. It is argued that the Reactors continue to rely on very early teleological or concrete behavioural defences which are interactive rather than interpsychic. Thus their behaviour is seen as immature, annoying and deliberate rather than archaic defences against anxiety where neither workers nor young people understand the powerful unconscious forces underlying their acting out.
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Koydemir, Selda. "Predictors Of Shyness Among University Students: Testing A Self-presentational Model." Phd thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/3/12607796/index.pdf.
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The present study investigated self-presentational predictors of shyness among university students via a mediational causal model, in which socially-prescribed perfectionism, perceived social skills, and perceived parental attitudes were proposed to interact with fear of negative evaluation and self-esteem to predict shyness. The sample consisted of 497 undergraduate students (287 females, 210 males) selected from Middle East Technical University by stratified random sampling. Brief Fear of Negative Evaluation Scale, Revised Cheek and Buss Shyness Scale, Socially-Prescribed Perfectionism Scale, Rosenberg Self-Esteem Scale, Social Skills Inventory-Short, and Parental Attitude Scale were used in data collection. Pilot studies were conducted for assessing the reliability and validity of Brief Fear of Negative Evaluation Scale, Revised Cheek and Buss Shyness Scale, and Social Skills Inventory-Short. Path analysis was utilized to test the causal model.
The results revealed that shyness was positively predicted from fear of negative evaluation and socially-prescribed perfectionismand negatively from self-esteem and perceived social skills. Fear of negative evaluation was predicted positively from socially-prescribed perfectionism and perceived strictness/supervision from parents, and negatively from self-esteem
whereas self-esteem was predicted positively from perceived social skills, perceived parental psychological autonomy and acceptance/involvement, and negatively from socially-prescribed perfectionism. These findings suggested that fear of negative evaluation partially mediated the relationship between shyness and socially-prescribed perfectionism
between shyness and perceived parental strictness/supervision
and between shyness and self-esteem. In addition, self-esteem partially mediated the association of shyness with socially-prescribed perfectionism
with perceived social skills
with parental acceptance/involvement
and with parental psychological autonomy. Findings are discussed within the self-presentational framework of shyness.
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Belluzzi, Chiara. "Academic and non-academic conference presentations - are they the same genre? Five case studies." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/9884/.
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Il presente elaborato si pone l’obiettivo di determinare se il genere del discorso di conferenza non accademica coincida con il genere del discorso di conferenza accademica, nello specifico per quanto riguarda le loro introduzioni.
La prima parte della tesi si concentra sulle basi teoriche. In primo luogo è stata sviluppata una panoramica della letteratura esistente riguardo ai discorsi di conferenza accademica, dalla quale si è poi ristretto il campo sugli studi che hanno preso in esame solo la loro introduzione.
Alla luce dell’assenza di pubblicazioni sulle conferenze non accademiche, e di conseguenza anche sui loro discorsi, si è cercato di definire il genere del discorso di conferenza non accademica, applicando il concetto di ‘comunità discorsiva’ sia ai discorsi di conferenza accademica sia a quelli di conferenza non accademica. Una volta stabilito che il contesto non accademico differisce da quello accademico, si è passati a definire l’introduzione dei discorsi di conferenza non accademica in quanto genere.
Nella seconda parte dell’elaborato è stata svolta l’analisi di cinque case study, ovvero della trascrizione delle introduzioni di cinque discorsi di conferenza non accademica. A queste è stato applicato il modello di mosse retoriche delle introduzioni dei discorsi di conferenza accademica elaborato da Rowley-Jolivet e Carter-Thomas, per determinare se fosse valido anche per le introduzioni dei discorsi di conferenza non accademica. Una volta scoperto che non lo è, e che quindi le introduzioni dei discorsi di conferenza non accademica e quelle dei discorsi di conferenza accademica sono due 'sotto-generi' diversi, è stato proposto un nuovo modello di mosse retoriche.
Infine sono stati avanzati dei suggerimenti riguardo all’applicabilità del suddetto modello, non solo in altri studi nel campo dell’analisi di genere, ma anche nel settore dell’interpretazione simultanea, con particolare riferimento alla preparazione dell’interprete e alla strategia di anticipazione.
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Campbell, Regan Helen. "An age-related comparison of audio and audio plus video presentation modes for conveying technical information." Thesis, Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/28612.
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Lowes, Katie. "Mechanisms of MHC-class II restricted presentation of aggrecan in an animal model of rheumatoid arthritis." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424292.
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Lewis, Christopher John. "The sovereignty of the author : modes of self-presentation in the work of Günter de Bruyn." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272284.
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Donlin, Joanne Mac. "Role of self-esteem and self-presentation concerns in reactions to performance feedback: a preliminary model." Thesis, Virginia Tech, 1987. http://hdl.handle.net/10919/45780.
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Several recent experiments have suggested that high versus low esteem persons differ in the extent to which they use interpersonal behaviors to cope with negative feedback from others. In particular, it has been suggested that low self-esteem persons attempt to enhance themselves in public but not privately whereas this difference does not exist for high self-esteem persons. The present study tested a proposed model of interpersonal reactions to performance feedback. The model was investigated through two experimental designs. Design la examined high self-esteem (HSE) and low self-esteem (LSE) subordinate's reactions to positive and negative performance feedback in a public versus private settings. Design is examined whether information about the subordinate's reactions affected the supervisor's ratings of the subordinate. Overall, the proposed model gained some empirical support. The prediction that LSE subordinates would engage in self presentational behaviors as a means of self-enhancement was partially supported in the positive feedback conditions, but not in the negative feedback conditions. As predicted, HSE subordinates showed no differences in reactions obtained in the public versus private setting, and as predicted, showed no increases in resultant esteem. The most striking support for the model comes from the correspondence between subordinate's reactions and subsequent supervisor ratings of the subordinate. This relationship emerged only when the supervisor had knowledge of the subordinate's reactions. The longer term effects of subordinates' reactions to feedback are discussed in reference to subordinate participation in performance appraisal meetings.Master of Science
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Freedman, Skiöld Felicia, and Saba Hossein-Chi. "Du Är Vad Du Delar : En kvalitativ studie i hur tre svenska mikro- influencers på Instagram ser på sin roll i och med kommersialiseringen." Thesis, Luleå tekniska universitet, Institutionen för konst, kommunikation och lärande, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-68540.
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Det digitala samhället kännetecknas av konstant utveckling och snabb föränderlighet, vilket har skapat rollen influencer: En person som används av företag och varumärken för att marknadsföra produkter eller tjänster. Denna studie fokuserar särskilt på influencerns egen bild av sitt yrke och genom att tematisera frågor utifrån teorier rörande kommersialisering, självpresentation, deltagarkultur och opinionsbildning. I studien undersöks hur tre utvalda svenska influencers inom mode och skönhet på Instagram ser på sin roll i och med kommersialiseringen vilket analyseras utifrån samma teorier inom medie- och kommunikationsvetenskapen som har nämnts ovan. Studien genomförs genom kvalitativa forskningsintervjuer där influencerna själva är utgångspunkten. Genom studien blir det tydligt att förstå hur kommersialiseringen har påverkat mediesamhället och tidigare roller har bytts ut. Kändisar är inte bara längre skådespelare och artister, opinionsledare behöver inte längre vara traditionella medier, en person kan ha olika roller i olika mediesammanhang och annonsering är inte längre något som går från producent till konsument. Utvecklingen av både medier och sociala kanaler har förändrat medielandskapet helt och de gränserna mellan avsändare och mottagare suddas ut. Det är inte bara marknadskommunikationen som har monopol på forskning rörande annonsering och marknadsföring. Avlutningsvis visar studien att influencerna har en sammansatt och komplex roll som uppstått i och med kommersialiseringen och är en följd utav en konvergens av det digitala medielandskapet.The digital society is characterized by constant development and rapid change, which has created the role influencer: A person used by companies and brands to market products or services. This study focuses on influencers own image of their occupation and by thematising issues based on theories of commercialization, self-presentation, participatory culture and opinion formation. The essay is exploring how three selected Swedish influencers in fashion and beauty at Instagram are looking at their role in commercialization which is analyzed on the basis of the same theories in media and communication science that have been mentioned above. The study is conducted through qualitative research interviews where the influencers themselves are the starting point. Through the study it becomes clear to understand how commercialization has affected the media community and previous roles have been replaced. Celebrities are no longer just actors and artists, opinion leaders no longer need to be traditional media, a person can have different roles in different media contexts and advertising is no longer something that goes from producer to consumer. The development of both media and social channels has changed the media landscape in so much as the boundaries between senders and recipients are being erased. It is not only market communication that has a monopoly on research relating to advertising and marketing. Lastly the study shows that influencers have a composite and complex role that has emerged through commercialization and is a consequence of a convergence of the digital media landscape.
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Osmanoglu, Esin. "An Architectural Study On Miniature Parks And Miniature Models: Miniaturk." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12605751/index.pdf.
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This thesis is an architectural study surveying on miniature parks and miniature models exhibited in them and particularly focuses on Miniaturk - the first miniature park of Turkey- located in Istanbul. It is established as an environment containing a group of miniature models of buildings and landscapes, which display the variety, and richness of the cultural tradition of the previous and contemporary Anatolian civilizations, and especially Ottoman grandeur. In this study, it is argued that Miniaturk stands as a hybrid category between a museum, a public park and entertainment centre. Miniaturk is also conceived as an architectural environment providing a possible ground to discuss the conceptions, misconceptions and presuppositions about architecture in the popular realm and in the professional and disciplinary framework. Thereby, Miniaturk is investigated through the processes of its production including the initial design idea and all the stages of its construction.
This study also tries to discuss the miniature models from different points of view. Whether they are considered as tools of architectural representation or not by the professionals, the popularity and the communicative advantage of these models can be used to arouse interest in the cultural and historical heritage as well as the contemporary architecture. The daily life of man on the street is strictly connected with architecturetherefore Miniaturk requires recognition as an environment for realization of these connections and relations.
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Chu, Hsiao-Yun. "R. Buckminster Fuller's model of nature : its role in his design process and the presentation and reception of his work." Thesis, University of Brighton, 2014. https://research.brighton.ac.uk/en/studentTheses/76f945d8-9def-4642-b27c-16518382bed5.
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R. Buckminster Fuller's design and architectural work is frequently described as being "inspired by nature". However, to date there has been little investigation of his claim. What was Fuller's understanding of "nature" and how did it affect the conception, production and presentation of his work? This thesis attempts to characterize R. Buckminster Fuller's understanding of nature, which will be called a model of nature, and to trace its impact upon his work over the course of his career using an interdisciplinary historical approach.
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Church, Donald Glen. "Reducing Error Rates in Intelligence, Surveillance, and Reconnaissance (ISR) Anomaly Detection via Information Presentation Optimization." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1452858183.
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Glansberg, Sven. "Presentation av reservdelskatalog med modellbaserat konstruktionsunderlag : En fallstudie av Saabs konceptutveckling för teknikinformation till stridsflygplanet Gripen NG." Thesis, Linköpings universitet, Interaktiva och kognitiva system, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-78701.
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Inom militär flygindustri är produktdatahantering i produktlivscykeln och utveckling av logistikstöd centrala områden för att hantera krav och kostnader. Senaste strategin för dessa utmaningar grundar sig i modellbaserat konstruktionsunderlag – model-based definition (MBD). I detta perspektiv står disciplinen teknikinformation inför förändringsarbetet att utnyttja möjligheterna med MBD. Förbättringar i presentationsmetod för illustrationer och effektivare arbetsmetoder för produktion förväntas. Detta förändringsarbete undersöktes genom en fallstudie av Saabs konceptutveckling för teknikinformation till stridsflygplanet Gripen NG. Studien fokuserade på publikationstypen reservdelskatalog och användningen av den. Arbetet bidrar med en modell som beskriver fyra nivåer för design av informationssystem, varav nivån presentation är i fokus. Därtill undersöks jämförbara arbetsmetoderför hantering av MBD-data inom fallet. Studien fann att teknikinformationsavdelningen står inför en övergång från dokumentbaserad förvaltning till utveckling av informationssystem. Därefter diskuteras tre förslag för nästa generations reservdelskatalog. Det mynnar ut i två slutsatser: dels att en bristfällig bild av reservdelskatalogens användning gör det svårt att bedöma nya presentationsmetoders lämplighet, och dels att förbättringarna gjorda i arbetsmetod och presentationsmetod vid MBD-införande på andra områden i produktlivscykeln inte är direkt överförbara på reservdelskatalogen. Till följd av detta presenteras förslag på framtida forskning och arbete.In the military aerospace industry, product data management in the product lifecycle, and development of logistics support are key areas that affect management of requirements and costs. The most recent strategy for these challenges is model-based definition (MBD). The discipline of technical communication has yet to explore and exploit the potential of MBD. Expected benefits include better ways of presenting illustrations and more efficient methodologies for production. This problem was investigated through a case study of the concept development of technical communication for Saab's fighter aircraft Gripen NG. The study focused on the illustrated parts catalog and its use. This work contributes with a model that describes four design levels for information systems, where presentation is the one in focus. In addition, comparable practices for management of MBD data were investigated in the case. The study found that the technical communication department is facing a transition from document-based management to development of information systems. Furthermore, three proposals for the next generation of parts catalogs are discussed. Two conclusions were reached. First, a lack of knowledge regarding the use of the parts catalog makes it difficult to assess new ways of presentation. And second, the improvements made in methodology and presentation in other MBD applications of the product life cycle are not immediately transferable to the parts catalog. Hence, suggestions for future research and work are presented.
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Akiel, Maaged A. "CHARACTERIZATION OF THE ROLE OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7 (IGFBP7) USING A GENETIC KNOCKOUT MOUSE MODEL." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4695.
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In the US, the incidence and mortality rates of hepatocellular carcinoma (HCC) are alarmingly increasing since no effective therapy is available for the advanced disease. Activation of IGF signaling is a major oncogenic event in diverse cancers, including HCC. Insulin-like growth factor binding protein-7 (IGFBP7) inhibits IGF signaling by binding to IGF-1 receptor (IGF-1R) and functions as a potential tumor suppressor for hepatocellular carcinoma (HCC). IGFBP7 abrogates tumors by inducing cancer-specific senescence and apoptosis and inhibiting angiogenesis. We now document that Igfbp7 knockout (Igfbp7-/- ) mouse shows constitutive activation of IGF signaling, presents with pro-inflammatory and immunosuppressive microenvironment, and develops spontaneous tumors in lungs and liver and markedly accelerated carcinogen-induced HCC. Loss of Igfbp7 resulted in increased proliferation and decreased senescence in hepatocytes and mouse embryonic fibroblasts that could be blocked by an IGF-1 receptor inhibitor. A significant inhibition of genes regulating immune surveillance was observed in Igfbp7-/- livers which was associated with marked inhibition in antigen cross presentation by Igfbp7-/- dendritic cells. IGFBP7 overexpression inhibited growth of HCC cells in syngeneic immune competent mice, which could be abolished by depletion of CD4+ or CD8+ T lymphocytes. Our studies unravel modulation of immune response as a novel component of pleiotropic mechanisms by which IGFBP7 suppresses HCC. Even though HCC has an immunosuppressive milieu, immune targeted therapies are beginning to demonstrate significant objective responses in clinical trials. IGFBP7 might be an effective anti-HCC therapeutic by directly inhibiting cancer cells and stimulating an anti-tumor immune response.
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Trauntschnig, Joakim, and Julia Lind. "Framework of Standardized Workstations for a Mixed-model Assembly Line : Material Presentation and Work Activities from a Time Efficient and Ergonomic Perspective." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Industriell organisation och produktion, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-41389.
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Purpose – The purpose of the study is to propose a framework for standardized workstations with focus on operators work activities and material presentation on a mixed-model assembly line. In order to fulfill the purpose, it was decomposed into three research questions: Research question 1: What problems in existing manual workstations can be identified, regarding work activities and material presentation? Research question 2: What can be considered regarding operators' work activities in creation of standardized workstations for a mixed-model assembly line? Research question 3: What can facilitate the work performance and ergonomics of operators when designing material presentation for standardized workstations for a mixed-model assembly line? Methodology – This study was carried out inductively through analysis of empirical data from a case study against existing theories from a literature study. Theories were in the areas of mixed-model assembly line, workstation design, material presentation, work activities, ergonomics and human aspect, and standardization and flexibility. To gather empirical data, a document study, observations and interviews were conducted at one case company. Findings – The study resulted in a framework for work activities and material presentation in standardized workstations on a mixed-model assembly line within the perspectives of ergonomics, standardization and non-value-added work. Results indicated on decreased efficiency if the involvement of human factor and standardization were insufficient in the workstation design, by increased non-value- added work and decreased ergonomics. Implications – The proposed framework intended to support companies to merge assembly lines into a mixed-model assembly line with low automation. Limitations – The framework in this study only focused on workstations' workactivities and material presentation. Workstations are linked to more than these two areas therefore should more areas be included in merging assembly lines. This framework had the perspectives of ergonomics, standardization and non-value-added work, more perspectives should be considered in a merger.
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Kunze, Matthias. "Searching business process models by example." Phd thesis, Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2013/6884/.
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Business processes are fundamental to the operations of a company.
Each product manufactured and every service provided is the result of a series of actions that constitute a business process.
Business process management is an organizational principle that makes the processes of a company explicit and offers capabilities to implement procedures, control their execution, analyze their performance, and improve them. Therefore, business processes are documented as process models that capture these actions and their execution ordering, and make them accessible to stakeholders. As these models are an essential knowledge asset, they need to be managed effectively.
In particular, the discovery and reuse of existing knowledge becomes challenging in the light of companies maintaining hundreds and thousands of process models.
In practice, searching process models has been solved only superficially by means of free-text search of process names and their descriptions. Scientific contributions are limited in their scope, as they either present measures for process similarity or elaborate on query languages to search for particular aspects. However, they fall short in addressing efficient search, the presentation of search results, and the support to reuse discovered models.
This thesis presents a novel search method, where a query is expressed by an exemplary business process model that describes the behavior of a possible answer. This method builds upon a formal framework that captures and compares the behavior of process models by the execution ordering of actions. The framework contributes a conceptual notion of behavioral distance that quantifies commonalities and differences of a pair of process models, and enables process model search.
Based on behavioral distances, a set of measures is proposed that evaluate the quality of a particular search result to guide the user in assessing the returned matches. A projection of behavioral aspects to a process model enables highlighting relevant fragments that led to a match and facilitates its reuse.
The thesis further elaborates on two search techniques that provide concrete behavioral distance functions as an instantiation of the formal framework. Querying enables search with a notion of behavioral inclusion with regard to the query. In contrast, similarity search obtains process models that are similar to a query, even if the query is not precisely matched.
For both techniques, indexes are presented that enable efficient search.
Methods to evaluate the quality and performance of process model search are introduced and applied to the techniques of this thesis. They show good results with regard to human assessment and scalability in a practical setting.Geschäftsprozesse bilden die Grundlage eines jeden Unternehmens, da jedes Produkt und jede Dienstleistung das Ergebnis einer Reihe von Arbeitsschritten sind, deren Ablauf einen Geschäftsprozess darstellen. Das Geschäftsprozessmanagement rückt diese Prozesse ins Zentrum der Betrachtung und stellt Methoden bereit, um Prozesse umzusetzen, abzuwickeln und, basierend auf einer Auswertung ihrer Ausführung, zu verbessern. Zu diesem Zweck werden Geschäftsprozesse in Form von Prozessmodellen dokumentiert, welche die auszuführenden Arbeitsschritte und ihre Ausführungsbeziehungen erfassen und damit eine wesentliche Grundlage des Geschäftsprozessmanagements bilden. Um dieses Wissen verwerten zu können, muss es gut organisiert und leicht auffindbar sein – eine schwierige Aufgabe angesichts hunderter bzw. tausender Prozessmodelle, welche moderne Unternehmen unterhalten. In der Praxis haben sich bisher lediglich einfache Suchmethoden etabliert, zum Beispiel Freitextsuche in Prozessbeschreibungen. Wissenschaftliche Ansätze hingegen betrachten Ähnlichkeitsmaße und Anfragesprachen für Prozessmodelle, vernachlässigen dabei aber Maßnahmen zur effizienten Suche, sowie die verständliche Wiedergabe eines Suchergebnisses und Hilfestellungen für dessen Verwendung. Diese Dissertation stellt einen neuen Ansatz für die Prozessmodellsuche vor, wobei statt einer Anfragesprache Prozessmodelle zur Formulierung einer Anfrage verwendet werden, welche exemplarisch das Verhalten der gesuchten Prozesse beschreiben. Dieser Ansatz fußt auf einem formalen Framework, welches ein konzeptionelles Distanzmaß zur Bewertung gemeinsamen Verhaltens zweier Geschäftsprozesse definiert und die Grundlage zur Suche bildet. Darauf aufbauend werden Qualitätsmaße vorgestellt, die einem Benutzer bei der Bewertung von Suchergebnissen behilflich sind. Verhaltensausschnitte, die zur Aufnahme in das Suchergebnis geführt haben, können im Prozessmodell hervorgehoben werden. Die Arbeit führt zwei Suchtechniken ein, die konkrete Distanzmaße einsetzen, um Prozesse zu suchen, die das Verhalten einer Anfrage exakt enthalten (Querying), oder diesem in Bezug auf das Verhalten ähnlich sind (Similarity Search). Für beide Techniken werden Indexstrukturen vorgestellt, die effizientes Suchen ermöglichen. Abschließend werden allgemeine Methoden zur Evaluierung von Prozessmodellsuchansätzen vorgestellt, mit welchen die genannten Suchtechniken überprüft werden. Im Ergebnis zeigen diese eine hohe Qualität der Suchergebnisse hinsichtlich einer Vergleichsstudie mit Prozessexperten, sowie gute Skalierbarkeit für große Prozessmodellsammlungen.
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Petar, Pejić. "Sistem prezentacije trodimenzionalnih modela arhitektonskih objekata metodom proširene stvarnosti." Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=108892&source=NDLTD&language=en.
Full textAbstract:
Metoda proširene stvarnosti omogućava prikaz stvarnog sveta dopunjenogvirtuelnim objektima i nalazi primenu u prezentaciji virtuelnih 3D modelaarhitektonskih objekata. U ovom istraživanju unapređen je konceptualniautomatski sistem za prezentaciju trodimenzionalnih modela arhitektonskihobjekata metodom proširene stvarnosti. Razvijen je novi algoritam zapravilan prikaz okluzije u sistemima prezentacije arhitektonskih objekatametodom proširene stvarnosti. Delovi ovog sistema su detaljnije razrađeni ucilju rešavanja određenih problema realističnosti prezentacije 3D modelaarhitektonskih objekata.The method of Augmented Reality enables a real world display,supplemented by virtual structures, and it finds its use in the presentation ofvirtual 3D models of architectural structures. In this research a conceptualautomatic system for the presentation of three-dimensional models ofarchitectural structures using the method of Augmented Reality is improved.Particular parts of this system are elaborated in more detail in order to solveparticular problems regarding the realistic displays of the presentation. Anew algorithm for correct occlusion handling in the presentation of 3D modelsof architectural structures by the method of Augmented Reality wasdeveloped.
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Eccleston, Ruth Charlotte. "A mechanistic model predicting cell surface presentation of peptides by MHC class I proteins, considering peptide competition, viral intracellular kinetics and host genotype factors." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10038760/.
Full textAbstract:
Major histocompatability complex class I (MHC-I) proteins present short fragments of pathogenic or cancerous proteins (peptides) on the surface of infected cells for recognition by T lymphocytes which are stimulated upon recognition of foreign peptides. Due to the diversity of peptide sequences and the sequence-specificity of MHC-I alleles, being able to determine which peptides will be presented by which MHC-I alleles and in what proportion could be important for the development of vaccines and treatments based on the presented peptiodome. Machine learning tools, trained on experimental data, are widely used to predict immunogenic peptides. However they are unable to account for the impact the intracellular kinetics of the pathogenic or cancerous protein which will greatly influence the resultant peptidome. Here we describe a mechanistic model of peptide presentation, validated against experimental data, which accounts for intracellular peptide concentration, and can predict the relative cell surface presentation of competing peptides with varying affinities for MHC-I proteins. We demonstrate how combining this mechanistic model with the intracellular kinetics of HIV proteins can provide insight in to the experimentally reported immunogenicity of the viral protein Gag, and show how such a model can be used to predict the most abundant viral peptides presented on the cell surface. Similarly, we predict the HeLa cell peptidome and demonstrate how a simple metric can be used to approximate the abundance of a peptide based solely on protein synthesis and degradation, peptide-MHC affinity and proteasomal cleavage.
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Rasche, Sarah S. "Processing and Presentation of Glutamic Acid Decarboxylase 65 T cell-Inducing Epitopes: Implications in the Non-Obese Diabetic Mouse Model of Type 1 Diabetes." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1290046839.
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Murdamoothoo, Devadarssen. "Immuno-modulatory functions of tenascin-C in a tumor progression model." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ049.
Full textAbstract:
La ténascine-C (TNC), protéine de la matrice extracellulaire, favorise la progression tumorale et la métastase par des mécanismes pas totalement élucidés. J’ai utilisé un nouveau modèle de progression tumorale de la glande mammaire basé sur une approche de greffe de cellules tumorales orthotopiques syngéniques et j’ai ainsi identifié la TNC comme un régulateur important de la croissance tumorale. L’expression concomitante de la TNC par les cellules de l’hôte et les cellules tumorales induit une régression de la tumeur en induisant une signature de présentation d’antigène. Cette signature a été corrélée avec une meilleure survie des patientes atteintes de cancer du sein. D’autre part, la TNC exprimée par les cellules tumorales induit également l’expression de CXCL12 au sein de la tumeur, piégeant les lymphocytes CD8+ dans des travées de matrice enrichies avec le CXCL12 lié à la TNC. L’inhibition du récepteur de CXCL12, le CXCR4 provoque une régression tumorale qui s’accompagne d’un afflux important de lymphocytes T CD8+ et d’une augmentation de la mort cellulaire au sein du lit tumorale. La séquestration des lymphocytes T cytotoxiques par la TNC dans les travées de matrice peut avoir une implication importante dans le développement et l’utilisation des nouvelles immunothérapies ciblant l’activité des cellules effectrices du système immunitaireThe extracellular matrix molecule tenascin-C (TNC) promotes tumor progression and metastasis by poorly understood mechanisms. I used a novel breast progression model based on a syngeneic orthotopic tumor cell grafting approach and identified TNC as an important regulator of tumor growth. I document that TNC promotes the battle between tumor regression and growth, where combined expression of tumor cell- and host-derived TNC induces tumor cell rejection. Tumor cell-derived TNC may elicit regression by induction of an antigen presenting signature (APS) expressed by the host, which correlates with better breast cancer patient survival. Tumor-cell derived TNC also triggers CXCL12 expression, thereby causing trapping of CD8+ T cells in the surrounding TNC matrix tracks. TNC binds CXCL12, and combined TNC/CXCL12 attracts and immobilizes CD8+ T cells. Inhibition of the CXCL12 receptor CXCR4 causes tumor regression that is accompanied by massive infiltration of CD8+ T cells and cell death inside the tumor cell nests. Altogether,TNC-triggered CXCL12 signaling may dampen CD8+ T cell function where physical trapping of CD8+ T cells in the TNC matrix may have implications for immune cell therapies. Our results and new tumor model, offer novel opportunities for preclinical cancer research and cancer patient therapy, by triggering the “good” and blocking the “bad” actions of TNC. In particular, overcoming the immune suppressive action of TNC, through inhibition of CXCR4, could be a useful approach