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Gallo, Peter, Romana Píchová, Anna Šenková, Daniela Matušíková, and Jana Mitríková. "TECHNIQUES AND ANALYSIS OF MANAGEMENT AUDITS." CBU International Conference Proceedings 5 (September 22, 2017): 132–37. http://dx.doi.org/10.12955/cbup.v5.914.
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The proper management of an enterprise involves a set of complex activities that, in the current rapidly changing world, require adoption of modern market requirements. This paper describes a study concerning management audits.The study aims to identify and evaluate the specific techniques that are useful for obtaining information for audits in evaluating management, and examines modifications and applications of the model by McKinsey, ‘model 7S’, with an ‘IFE Matrix’. As practice shows, until now, the ‘model 7S’ approach is the most frequently used tool to assess the current state of management executives in business. The proposed models in the paper’s conclusion can be used individually or by combining two separate models to create a ‘two-staged adaptive model 7S’.
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Park, Hyunae, Youngcheon Yoo, and Hwansoo Lee. "7S Model for Technology Protection of Organizations." Sustainability 13, no. 13 (June 22, 2021): 7020. http://dx.doi.org/10.3390/su13137020.
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Given the importance of technologies to organizations, technology leakages can cause considerable financial losses and threaten the survival of firms. Although organizations use technology protection diagnostic models to prevent such leakages, most diagnostic models focus on cybersecurity, and the evaluation system is complex, making it difficult for SMEs to use it. This makes them unsuitable for the general technology protection diagnosis of companies. Hence, this study proposes a diagnostic model that assesses these technology protection capabilities of organizations from personnel and administrative perspectives. Drawing upon the individual elements of the 7S model—shared values, strategy, structure, systems, staff, style, and skills—our model analyzes the influence of the elements on the technology protection capabilities of organizations. To determine this influence, the study conducts a questionnaire survey among 435 employees from large, larger medium-sized, and small and medium enterprises. Using the partial least squares and the artificial neural network methods, the study determines the ranking of the relative importance of the 7s elements. The results show that the shared values element most significantly influences these capabilities. The remaining elements influence the technology protection capabilities in the following order from the greatest to the least effect: staff, strategy, structure, systems, style, and skills. These findings highlight the significance of developing an awareness of the necessity of technology protection among all the members of an organization.
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Cox, Andrew Martin, Stephen Pinfield, and Sophie Rutter. "Extending McKinsey’s 7S model to understand strategic alignment in academic libraries." Library Management 40, no. 5 (June 10, 2019): 313–26. http://dx.doi.org/10.1108/lm-06-2018-0052.
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Purpose The purpose of this paper is to conceptualise the issues of alignment for changing academic libraries by using and extending McKinsey’s 7S model. Design/methodology/approach Theoretical work was conducted to consider and extend the 7S model for the situation of academic libraries. Empirical data were then used to confirm the value of these extensions and suggest further changes. The data to support the analysis were drawn from 33 interviews with librarians, library and non-library academics and experts, and a survey of UK library staff. Findings In the academic library context, the 7S model can be usefully extended to include three library functions (stuff, space and services) and users. It can also include institutional influences and stakeholders, and aspects of the external environment or situation, including suppliers and allies. The revised model then provides a useful framework within which data about library change can be analysed. Perceived barriers to successful performance fit the model and enable the identification of seven challenges of alignment. Research limitations/implications The resulting model has potential applications such as in the structuring analysis of academic library performance, mapping future directions of development and for exploring variations across the sector and internationally. Practical implications The revised model can be used by practitioners to think through their own strategic position and to act to shape their future, in the light of seven major areas of alignment. Originality/value The paper extends a well-known model used in strategy, to produce a more comprehensive, sector-specific analytic tool.
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., Sasmoko, Yasinta Indrianti, Anindyo Widhoyoko, and Rochmat Wahab. "Organizational Diagnostic Model in Higher Education: Literature Review of Organizational Diagnostic Model through Mckinsey 7s Framework Model, Weisboard 6 Boxes Model and National Education Standards in Indonesia." International Journal of Engineering & Technology 7, no. 3.30 (August 24, 2018): 293. http://dx.doi.org/10.14419/ijet.v7i3.30.18264.
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Organizational diagnosis is done for organizational development and change. This study aims to further examine the concept of an organizational model that tries to cultivate the McKinsey 7S Framework Model and the Weisbord Six Box Model with the National Standards of Higher Education. This research uses Neuroresearch research method, which is a research method that combines quantitative and qualitative research with an exploratory stage. The result of the research shows the design of Organizational Diagnostic Model for Higher Education in Indonesia which consists of Strategy, Structure, System, Skill, Staff, Leadership, Value and Purpose (SNPT) consisting of Education Standard, Research Standard, and Standard of Community Service.
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Seo, Young, and Sang-Ho Lee. "The Effect of Organizational Diagnosis Model 7S Factors on the Task Environment and Job Satisfaction of Performing Arts Institutions." Journal of Humanities and Social sciences 21 9, no. 1 (February 28, 2018): 427–40. http://dx.doi.org/10.22143/hss21.9.1.34.
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Hanafizadeh, Payam, and Ahad Zare Ravasan. "A McKinsey 7S Model-Based Framework for ERP Readiness Assessment." International Journal of Enterprise Information Systems 7, no. 4 (October 2011): 23–63. http://dx.doi.org/10.4018/jeis.2011100103.
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Implementing Enterprise Resource Planning (ERP) systems is a complex, lengthy and expensive process which usually faces serious challenges and failures. Thus, it is necessary to perform a readiness assessment at the initial stage of an ERP implementation project to identify weakness areas which may encounter the project with failure. This paper proposes a new framework for assessing readiness of an organization to implement the ERP project on the basis of McKinsey 7S model using confirmatory factor analysis. Through this method, the construct of ERP readiness is proposed based on 7 dimensions namely “structure”, “strategy”, “systems”, “skills”, “style/culture”, “staff”, and “shared values/ superordinate goals”. Using the framework, the current situation of the organization can be determined and necessary changes can be made prior to system implementation. The proposed framework is then applied to 2 real Iranian banking cases and the advantages of the framework over available frameworks are illustrated.
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Shaqrah, Amin A. "Analyzing Business Intelligence Systems Based on 7s Model of McKinsey." International Journal of Business Intelligence Research 9, no. 1 (January 2018): 53–63. http://dx.doi.org/10.4018/ijbir.2018010104.
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Business intelligence system (BIS) reflect on the foundation of completive advantage approaches, this article enhances previous articles of BIS implementation by analyzing a 7 McKinsey model. Using a Delphi survey method with sixty of managers and experts in the BIS field, the results from twenty pharmaceutical manufacturing industries deploying business intelligence applications are presented. The author surveyed a qualitative methodology to hypothesize a proposed model. The findings demonstrated that 80% of participants believe that both the hard and soft 7 dimensions of a McKinsey model—strategy, style, structure, staff, systems, skills, and shared values—are antecedents for successful BIS implementation. Precisely, shared value dimensions is the highest value affected by BIS implementation and skills dimension is the lowest value.
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Meštrović, Toni, Danko Kezić, Ivica Pavić, and Srđan Vukša. "Petri Net Model Of Supply Vessel Consumption As Function Of The Nature Of The Business And The State Of The Wind And Sea." Pedagogika-Pedagogy 93, no. 7s (August 31, 2021): 73–85. http://dx.doi.org/10.53656/ped21-7s.06petr.
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The state of prices and the development of a given economy depends largely on the gas and oil industry. Every day the gas and oil industry is growing and there is a growing need for platforms. In order for the platforms to pump gas and oil from the seabed unhindered, it is necessary to supply the platform which is done by supply vessels. In this paper, with the help of Petri nets and the tool “Yasper”, the dynamic process of supply and operation of supply vessels is simulated. Simulation is depending on the wind and wave conditions and the type of work that the supply vessel performs in cooperation with the platform. Input data are: Sea state, wind state, fuel consumption, type of vessel operation, distance from the mainland and the number of daily departures of the vessels from the port. The paper presents a model with discrete events in the process of supplying the platform, starting from the port and going out to sea until the work around the platform is completed and returning to the port. The report can provide information on the usability of the vessels and the approximate cost of the supply vessels on a voyage from port to the platform and back.
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Razmi, Jafar, Mahmood Mehrvar, and Anis Hassani. "An Assessment Model of McKinsey 7S Model-Based Framework for Knowledge Management Maturity in Agility Promotion." Journal of Information & Knowledge Management 19, no. 04 (November 27, 2020): 2050036. http://dx.doi.org/10.1142/s0219649220500367.
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In today’s knowledge-based advanced world, pioneer organisations emphasise more on knowledge orientation, being leaders in knowledge management (KM) implementation. The purpose of this paper is to identify the key factors influencing the successful implementation of each KM process in Iranian Oil and Gas Industry, specifically about operational projects which are classified based on the McKinsey 7S model as KM enablers, namely, strategy, structure, system, skill, style, staff and shared values. Then the paper assesses the KM maturity level to categorise and prioritise the KM enablers in each level. Moreover, a conceptual model is proposed to theorise the relationship between organisational agility and each KM process, namely, knowledge creation, storage, sharing and utilisation. Data analysis and statistical tests are concluded using structural equation model through the combination of confirmatory factor and path analysis. The results show the validity and fitness of the proposed model and verification of all the hypotheses, i.e. there are positive relationships between each KM process and agility.
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Benedict, Knud, Michèle Schaub, Michael Baldauf, Michael Gluch, Matthias Kirchhoff, and Caspar Krüger. "New Results For Teaching Ship Handling Using Fast Time Simulation." Pedagogika-Pedagogy 93, no. 7s (August 31, 2021): 167–84. http://dx.doi.org/10.53656/ped21-7s.15new.
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Some years ago, the SAMMON software tool box was introduced for “simulation augmented manoeuvring design, monitoring & conning”. It is based on the innovative “rapid advanced prediction & interface technology” (RAPIT) to simulate the ships motion by fast time simulation FTS with complex dynamic math models and to display the ships track immediately in an electronic sea chart for any rudder, thruster or engine manoeuvre planned by the navigator.specifically, the SAMMON planning tool will be shown in its opportunities for achieving new knowledge for teaching of ships dynamic and training of ship handling elements. That system represents the full information from ships’ manoeuvring documentation and from additional trial results squeezed in a ship dynamic model, capable of simulating environmental effects by using the RAPIT technology. The paper introduces the variety of opportunities of the training tools by presenting use case studies, e.g. For drifting under wind and how to get simple formulas for drift speed related to wind speed. Additionally, two complex manoeuvring strategies for a port arrival scenario will be compared for a ship with azimuth propeller to find out potential alternatives with less fuel consumptions and emissions.
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Canseco-González, Daniel, José Luis Rodríguez de la O, and José Enrique Herbert-Pucheta. "Combined XRD-paramagnetic 13C NMR spectroscopy of 1,2,3-triazoles for revealing copper traces in a Huisgen click-chemistry cycloaddition. A model case." Heterocyclic Communications 25, no. 1 (November 28, 2019): 98–106. http://dx.doi.org/10.1515/hc-2019-0018.
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AbstractCopper-catalyzed Alkyne-Azide Cycloaddition (CuAAC) click chemistry robustness has been demonstrated over recent years to produce 1,2,3-triazoles with excellent yields at mild conditions with simple purification methods. However, the consequences of having copper paramagnetic traces in final products, which complicate spectroscopic assignments and can produce inaccurate conclusions, has been scarcely discussed. Herein we present a strategy that combines X-Ray Diffraction (XRD) with 13C- paramagnetic Nuclear Magnetic Resonance spectroscopy, in order to demonstrate the presence of paramagnetic metal traces at standard Huisgen synthesis and purification conditions. We also demonstrate that the derivatization of 1,4-disubstituted-1,2,3-triazoles to produce 1,3,4,-trisubstituted-1,2,3.triazolium salts, promotes an efficient removal of Cu(II/I) moieties. Evidence of paramagnetic metal moieties is given using XRD structural analysis of abnormalities in torsional angles between substituents and the 1,2,3-triazole center, in parallel to 13C- paramagnetic NMR chemical shift and line width analysis. As model systems to demonstrate the importance of characterizing paramagnetic traces, we present the synthesis of novel 1-((3s,5s,7s)-adamantan-1-yl)-4-cyclopropyl-1H-1,2,3-triazole and its derivatized 1-((3s,5s,7s)-adamantan-1-yl)-4-cyclopropyl-3-methyl-1H-[1,2,3]-triazol-3-ium triflate salt.
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Zuhriah, Aminatuz, Tantri Yanuar Rahmat Syah, and Ratna Indrawati L. "HR Planning Using the McKinsey 7S Model Concept for Start Up Maternity Clinic." IARJSET 5, no. 9 (September 30, 2018): 14–20. http://dx.doi.org/10.17148/iarjset.2018.593.
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Vinuesa, Miguel A., Norberto D. Bassan, Ana I. Cases, and Gustavo Krumrick. "SENSITIZATION AND INHALATORY CHALLENGE WITH OVALBUMIN INCREASED CD4- AND CD5-POSITIVE CELLS IN TRACHEAL MUCOSA FROM A RABBIT MODEL." Chest 136, no. 4 (October 2009): 7S. http://dx.doi.org/10.1378/chest.136.4_meetingabstracts.7s-b.
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Savolainen, E. R., D. Brocks, L. Ala-Kokko, and K. I. Kivirikko. "Serum concentrations of the N-terminal propeptide of type III procollagen and two type IV collagen fragments and gene expression of the respective collagen types in liver in rats with dimethylnitrosamine-induced hepatic fibrosis." Biochemical Journal 249, no. 3 (February 1, 1988): 753–57. http://dx.doi.org/10.1042/bj2490753.
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Dimethylnitrosamine (DMN)-induced liver fibrosis was used as an experimental model to study the relationship between serum concentrations of the N-terminal propeptide of type III procollagen [S-Pro(III)-N-P] and the N-terminal (S-7S) and C-terminal (S-NC1) domains of type IV collagen and hepatic concentrations of type III and IV collagen mRNAs. Increases in S-Pro(III)-N-P, and especially in the two type IV collagen-related antigens, were found to be early events in the formation of DMN-induced hepatic fibrosis. The mean concentration of S-Pro(III)-N-P was 120% of the control mean on day 7 of DMN treatment, 230% on day 14 and 250% on day 21. The corresponding values for S-7S were 260, 950 and 1100% and, for S-NC1, 310, 820 and 1000%. All these changes were very similar to those found in the hepatic concentrations of the respective mRNAs. These data support a previous suggestion that an enhanced production of basement-membrane (type IV) collagen is an early event in the development of the DMN-induced hepatic fibrosis. The results also indicate that S-7S and S-NC1 are very sensitive indicators of changes in type IV collagen metabolism. Data obtained in gel-filtration experiments for these three serum antigens were consistent with the suggestion that all three antigens are mainly derived from the synthesis of the respective collagens.
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Vogel, John S., and Jason A. Giacomo. "Increased 14C AMS Efficiency from Reduced Competitive Ionization." Radiocarbon 59, no. 3 (June 29, 2016): 957–65. http://dx.doi.org/10.1017/rdc.2016.38.
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AbstractObservation of 80 µA/mm2 C– current from a 0.5-mm-diameter sample compared to 20 µA/mm2 from a 1-mm-diameter sample contradicts the long-held surface ionization hypothesis of cesium sputter ion source operation. Resonant ionization occurs in neutral Cs plasma above a sample in a sputtered pit or well. A collision-radiation model of that plasma followed electronic excitation and radiation relaxation up to the Cs(7d) state. The Cs(5d) metastable state dominates plasma in a 1-mm-diameter well, but high electron densities in narrow wells drive a majority to Cs(7d) and higher. Competitive ionization by Al2 dimers from the sample holder reduces Cs(7s,p) states resonant in ionization energy with C–. Al anions from states above Cs(7p) in narrow wells also diminish radiation cascades to the Cs(7s,p), reducing C–. We tested sample wells of non-ionizing Zn to maintain high ionization efficiency for small samples in narrow wells.
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Brozović, Vladimir, Danko Kezić, Rino Bošnjak, and Filip Bojić. "S-101 Charts, Database Tables For S-101 Charts, Autonomous Vessel." Pedagogika-Pedagogy 93, no. 7s (August 31, 2021): 22–35. http://dx.doi.org/10.53656/ped21-7s.02s101.
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This article shows a way to store the data of many S-101 charts into a single Postgres database. The data model of the database with all tables is shown and explained. The concatenation of the indices from the different database tables is explained. This concatenation allows for a faster search of points/curves with certain properties. This fulfills one of the basic requirements for the purpose of navigating an autonomous vessel – that several charts can be interpreted simultaneously by a machine. Mechanisms for up-dating the database with new charts not yet present in the database are shown. Also the mechanisms for updating the charts already present in the database are explained. System limitations are briefly presented to show that in practical use there are in fact none. Memory requirements for such a type of chart storage in the database is compared with memory requirements for ISO8211 files normally used for storage of S-101 charts. With small examples it is finally shown how the stored chart information can be searched specifically.
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Haleem, Fazal. "Planning Change in an Organization; MCB Bank Limited, Pakistan." Journal of Central Banking Theory and Practice 4, no. 2 (May 1, 2015): 75–107. http://dx.doi.org/10.1515/jcbtp-2015-0010.
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Abstract This paper is primarily based on a case study of a leading bank in Pakistan, that is, MCB Bank Ltd. Four established change models have been applied to the bank to find out how a change comes in/ is brought in, managed, and how it affects organizational environment and its stakeholders, particularly customers and employees. The four established change models applied are the change management approach by Ansoff and McDonnell; the change management model by Kurt Lewin; the 7S framework by Thoman J. Peters and Robert H. Waterman; and the change management model developed by Stephanie Elam. The study covers a change management aspect such as strategic intervention technique; a need for change management; resource implication; planning change; strategies in change management; system effectiveness; managing resistance to change; leadership issues; cultural issues; people issues; external environment issues; workable approach to overcome change resistance; appropriate model and implementing the model.
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Mattè, Alessandro, Antonio Recchiuti, Charles Serhan, Angela Siciliano, Enrica Federti, Olga Weinberg, Brian Kalish, Carlo Brugnara, and Lucia De Franceschi. "Resolvin D1 and Resolvin D2 Protect Against Hypoxia/Reoxygenation Induced Lung and Kidney Damage in a Sickle Cell Mouse Model of Acute Vaso-Occlusive Crisis." Blood 126, no. 23 (December 3, 2015): 966. http://dx.doi.org/10.1182/blood.v126.23.966.966.
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Abstract Sickle cell disease (SCD) is characterized by hemolytic anemia in association with acute and chronic life-threatening clinical complications. Acute vaso-occlusive crisis (VOCs) are the main cause of hospitalization for SCD patients. In VOCs, amplified inflammatory response plays a key role in acute organ damage. Pro-Resolving lipid mediators such as resolvins (Rv) accelerate resolution of acute inflammation in different models, indicating that stimulation of endogenous resolution of inflammatory processes may be an additional strategy in limiting tissue damage. Recent data suggest beneficial effects of Rvs in hypoxia/reoxygenation (H/R) related tissue injury. Here, we study the effects of Rvs on a model of acute VOCs using humanized SCD mice (Hbatm1(HBA)Tow Hbbtm2(HBG1,HBB*)Tow). We treated SCD and control healthy mice (AA, Hbatm1(HBA)Tow Hbbtm3(HBG1,HBB)Tow) (n =6-7 animals in each group) with RvD1, 7S, 8R, 17S- trihydroxy-docosa-4Z, 9E, 11E, 13Z, 15E, 19Z-hexaenoic acid, 17R- RvD1, 7S, 8R, 17R- trihydroxy-docosa-4Z, 9E, 11E, 13Z, 15E, 19Z-hexaenoic acid; RvD2, 7S, 16R, 17S-trihydroxy-docosa-4Z, 8E, 10Z, 12E, 14E, 19Z-hexaenoic acid. Mice were treated with RvD1 and RvD2 at the dose of 2.5 ug/Kg by gavage 1 hour (hr) before H/R stress (10 hrs 8% oxygen followed by 3 hrs reoxygenation), which we have used in the past to mimic acute VOCs. We found that RvD1 and RvD2 significantly reduced the H/R-induced (i) increase in neutrophil count; (ii) lung inflammatory cell infiltrate, mucus and thrombi formation; (iii) glomerular inflammatory cell infiltration, glomerular sclerosis and thrombi formation. In the lung of H/R SCD mice, RvD1 prevented the H/R induced up-regulation of (i) cytokines such as MCP2, IL-6 and ET-1; (ii) vascular endothelial activation markers (VCAM-1 and ICAM-1; (iii) cytoprotective systems such as Prx6 and HO-1. In the kidney of H/R SCD mice, RvD1 significantly reduced H/R induced expression of IL-6 and ET-1 as well as HO-1. Our data indicate that RvD1 and RvD2 modulating inflammatory responses related to H/R in SCD, protect sickle cell target organs, and foster resolution. Thus, RvD1 and RvD2 might represent a novel therapeutic approach for acute VOCs in SCD. Disclosures No relevant conflicts of interest to declare.
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Kim, Hwikyung, and Insook Kim. "7S Model Application Case for Organization Culture Development Activities in Small and Medium Sized Firm." Korea Association of Education Consulting and Coaching 5, no. 1 (March 31, 2021): 5–24. http://dx.doi.org/10.31137/ecc.2021.5.1.5.
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Mitsunaga Junior, Jorge Kiyoshi, Alfredo Gragnani, Maria Luiza Christóvão Ramos, and Lydia Masako Ferreira. "Rat an experimental model for burns: A systematic review." Acta Cirurgica Brasileira 27, no. 6 (June 2012): 417–23. http://dx.doi.org/10.1590/s0102-86502012000600010.
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PURPOSE: To revise and systematize scientific knowledge of the experimental model for cutaneous burns in rats. METHODS: A bibliographical review from 2008 up to January 2011 in PubMed, EMBASE and LILACS was undertaken. Were used the keywords: animal models, burns and rats. 221 studies were identified, and 116 were selected. RESULTS: It was found that: 54/86 (62.7%) had third degree burns; 55/73 (75.3%) studied the back; 45/78 (57.6%) used heated water and 27/78 (35.9%) incandescent instruments; 39/78 (50%) studied systemic effects; 22/71 (31%) used ketamine associated with xylazine; 61/64 (95.3%) performed depilation with appropriate equipment; 36/72 (50%) used microscopy; more than 50% did not describe analgesia or antibiotics during the postoperative period; in 42/116 (36.2%) postoperative fluid therapy was performed; and the time interval after the burn, up to the beginning of the results analysis varied from 7s up to four weeks. Legislation issues on burn experiments are discussed. CONCLUSION: The hot water was the main method to induce burns those of third degree on the back, with anesthesia using ketamine and xylazine, after depilation. These were evaluated microscopically, without using analgesia or an antibiotic during the postoperative period. The studies were not very reproducible.
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., Supartono, and I. Nengah Putra. "Applied Mckinsey 7S–Borda Method as an Assessment Model of Education System to Support Naval Technology Mastery." Journal of Engineering and Applied Sciences 14, no. 17 (November 10, 2019): 6303–11. http://dx.doi.org/10.36478/jeasci.2019.6303.6311.
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Gandhi, N. Mohan Das, V. Selladurai, and P. Santhi. "Computer integration using the McKinsey's 7S model as an underlying framework: a case study in the foundry." International Journal of Information Technology and Management 5, no. 2/3 (2006): 175. http://dx.doi.org/10.1504/ijitm.2006.010125.
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Atsukawa, Masanori, Akihito Tsubota, Chisa Kondo, Sawako Uchida-Kobayashi, Koichi Takaguchi, Akemi Tsutsui, Akito Nozaki, et al. "A novel noninvasive formula for predicting cirrhosis in patients with chronic hepatitis C." PLOS ONE 16, no. 9 (September 10, 2021): e0257166. http://dx.doi.org/10.1371/journal.pone.0257166.
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Evaluating liver fibrosis is crucial for disease severity assessment, treatment decisions, and hepatocarcinogenic risk prediction among patients with chronic hepatitis C. In this retrospective multicenter study, we aimed to construct a novel model formula to predict cirrhosis. A total of 749 patients were randomly allocated to training and validation sets at a ratio of 2:1. Liver stiffness measurement (LSM) was made via transient elastography using FibroScan. Patients with LSM ≥12.5 kPa were regarded as having cirrhosis. The best model formula for predicting cirrhosis was constructed based on factors significantly and independently associated with LSM (≥12.5 kPa) using multivariate regression analysis. Among the 749 patients, 198 (26.4%) had LSM ≥12.5 kPa. In the training set, multivariate analysis identified logarithm natural (ln) type IV collagen 7S, ln hyaluronic acid, and ln Wisteria floribunda agglutinin positive Mac-2-binding protein (WFA+-Mac-2 BP) as the factors that were significantly and independently associated with LSM ≥12.5 kPa. Thus, the formula was constructed as follows: score = −6.154 + 1.166 × ln type IV collagen 7S + 0.526 × ln hyaluronic acid + 1.069 × WFA+-Mac-2 BP. The novel formula yielded the highest area under the curve (0.882; optimal cutoff, −0.381), specificity (81.5%), positive predictive values (62.6%), and predictive accuracy (81.6%) for predicting LSM ≥12.5 kPa among fibrosis markers and indices. These results were almost similar to those in the validated set, indicating the reproducibility and validity of the novel formula. The novel formula scores were significantly, strongly, and positively correlated with LSM values in both the training and validation data sets (correlation coefficient, 0.721 and 0.762; p = 2.67 × 10−81 and 1.88 × 10−48, respectively). In conclusion, the novel formula was highly capable of diagnosing cirrhosis in patients with chronic hepatitis C and exhibited better diagnostic performance compared to conventional fibrosis markers and indices.
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Winie, Tan, F. H. Muhammad, and N. H. A. Rosli. "Effect of Anion Size on the Conductivity Behaviour of Hexanoyl Chitosan-Based Polymer Electrolytes." Advanced Materials Research 545 (July 2012): 317–20. http://dx.doi.org/10.4028/www.scientific.net/amr.545.317.
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Films of hexanoyl chitosan containing lithium perchlorate (LiClO4) or lithium triflouromethanesulfonate (LiCF3SO3) were prepared by solution casting technique. The effect of anion size on the conductivity behaviour of hexanoyl chitosan has been investigated. The conductivity of 4.15 × 10-7S/cm and 4.07 × 10-6S/cm were achieved for the hexanoyl chitosan-LiClO4and hexanoyl chitosan-LiCF3SO3electrolyte system at 50wt.% of salt concentration, respectively. The Rice and Roth model was used to analysis quantitatively the obtained conductivity trends for the prepared electrolyte systems. The diffusion coefficients of cations and anions were calculated from the conductivity and transference number measurements. This is followed by the discussion on the diffusion coefficients of ClO4-and CF3SO3-anion.
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Allen, JM, JC Yeats, AJ Cross, TJ Crow, and SR Bloom. "Neuropeptide Y and Monoamine and Concentrations in Marmosets Treated with MPTP: A Model of System for Parkinson 7s Disease." Clinical Science 68, s11 (January 1, 1985): 71P—72P. http://dx.doi.org/10.1042/cs068071pb.
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Verma, Anshul, Kartik Dave, K. R. Chari, and Chanchal Kushwaha. "Kesineni Tours and Travels." Emerald Emerging Markets Case Studies 2, no. 3 (August 10, 2012): 1–10. http://dx.doi.org/10.1108/20450621211237220.
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Subject area Strategy. Study level/applicability Post-Graduate and Executive Programmes in Management. Case overview Mr Srinivas Kesineni has been chairman of Kesineni Tours and Travels for the last 19 years. Kesineni Tours and Travels is one of the fastest growing bus travel and transport organisations. The case describes the journey of Kesineni Tours and Travels since its inception. It also outlines different strategies adopted by the Chairman to reach newer heights, to survive and to grow in the turbulent times of changing technology and rising competition from different means of transportation. This unique organisation is run by family, friends and well-wishers of the owners, yet it is professional in its approach in operations. The board of directors of Kesineni Tours and Travels has approved the financial results of 2010, which shows 55 percent growth and Rs 86.71 crores turnover. This is a remarkable achievement and recognition for a company that has been in the business since 1992. In early 1992, entrepreneur Mr Srinivas Kesineni thought of a bus transportation business when he started with just two buses, and today when the organization is the largest tour and travel company in the region serving approximately 15 lack customers in a year covering 75 destinations with around 425 daily schedules. He and his team have been working tirelessly and the company has a remarkable presence in the tour and travel business in India with occasional innovative moves from optimising bus routing, initiating sleeper coaches, introducing Volvo buses to the fleet, entering the cargo transportation business and more. This business has grown at CAGR of 24.07 percent since 2000-2001. Students reading this case may come to the class with preconceived views that the journey of the organisation since its beginning is an ordinary story, but this case creates an opportunity for students to come to their own conclusion how different strategies and the synthesis is important for achieving desired outcomes form time to time. This case facilitates the deductive learning process by identifying different strategic elements form the case and to understand its synergy to explain McKinsey 7s framework. Expected learning outcomes These include: understanding different strategies and policies adopted by the organisation and its impact on performance; understanding the importance of alignment of processes and departments in achievement of organisational strategy; and analysing and understanding the concept of the McKinsey 7S Framework, which is a helpful tool to understand the performance of the organisation. Supplementary materials Teaching notes are available. Bradach, Jaffrey, Organisational Alignment: The 7S Model, Harvard Business School Publishing are useful for further reading.
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Kottenberg-Assenmacher, Eva, Ivan Aleksic, Mareike Eckholt, Nils Lehmann, and Jürgen Peters. "Critical Closing Pressure as the Arterial Downstream Pressure with the Heart Beating and during Circulatory Arrest." Anesthesiology 110, no. 2 (February 1, 2009): 370–79. http://dx.doi.org/10.1097/aln.0b013e3181942c99.
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Background Calculation of systemic vascular resistance, used for hemodynamic decision-making, is based on central venous pressure taken as the downstream pressure. However, during circulatory arrest, arterial pressure decreases to a plateau higher than central venous pressure, the critical closing pressure (Pcrit). The authors assessed in humans undergoing arrest whether two-compartment and pressure-dependent conductivity models better estimate arterial pressure decay and Pcrit than a single-compartment model, and whether Pcrit corresponds to Pcrit calculated with the heart beating. Methods Aortic pressure decay was fitted to single-compartment, two-compartment, and pressure-dependent conductivity models using specified time intervals during arrest and natural diastole in 10 patients during defibrillator implantation. Results Although all models closely predicted Pcrit with an arrest of > or = 7s, both two-compartment and pressure-dependent conductivity models better estimated pressure decay than a single-compartment model. However, Pcrit calculated from natural diastolic pressure decay was greater (53 mmHg +/- 15.6) than Pcrit 15 s (26.6 mmHg +/- 7.8, P = 0.001) and 30 s (23.9 mmHg +/- 7.1, P = 0.001) during arrest, and also greater than Pcrit calculated for the same time interval during initial arrest. Conclusions Thus, during arrest, Pcrit can be closely predicted after > or = 7 s, regardless of the model; two-compartment and pressure-dependent conductivity models provide a better fit than a single-compartment model, and actual Pcrit is much less than Pcrit calculated with the heart beating. Irrespective of uncertainties in whether Pcrit calculated with the heart beating or during arrest is the "true" Pcrit prevailing physiologically, linear vascular resistance is markedly less when substituting Pcrit for central venous pressure as the downstream pressure.
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Makkonen, R., A. Asmi, H. Korhonen, H. Kokkola, S. Järvenoja, P. Räisänen, K. E. J. Lehtinen, et al. "Sensitivity of aerosol concentrations and cloud properties to nucleation and secondary organic distribution in ECHAM5-HAM global circulation model." Atmospheric Chemistry and Physics 9, no. 5 (March 9, 2009): 1747–66. http://dx.doi.org/10.5194/acp-9-1747-2009.
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Abstract. The global aerosol-climate model ECHAM5-HAM was modified to improve the representation of new particle formation in the boundary layer. Activation-type nucleation mechanism was introduced to produce observed nucleation rates in the lower troposphere. A simple and computationally efficient model for biogenic secondary organic aerosol (BSOA) formation was implemented. Here we study the sensitivity of the aerosol and cloud droplet number concentrations (CDNC) to these additions. Activation-type nucleation significantly increases aerosol number concentrations in the boundary layer. Increased particle number concentrations have a significant effect also on cloud droplet number concentrations and therefore on cloud properties. We performed calculations with activation nucleation coefficient values of 2×10−7s−1, 2×10−6s−1 and 2×10−5s−1 to evaluate the sensitivity to this parameter. For BSOA we have used yields of 0.025, 0.07 and 0.15 to estimate the amount of monoterpene oxidation products available for condensation. The hybrid BSOA formation scheme induces large regional changes to size distribution of organic carbon, and therefore affects particle optical properties and cloud droplet number concentrations locally. Although activation-type nucleation improves modeled aerosol number concentrations in the boundary layer, the use of a global activation coefficient generally leads to overestimation of aerosol number. Overestimation can also arise from underestimation of primary emissions.
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Raušer, Daniel. "Small and Medium-Sized Enterprises in Rural Areas of the Czech Republic and Their Approach to Management Auditing." SHS Web of Conferences 90 (2021): 01017. http://dx.doi.org/10.1051/shsconf/20219001017.
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Regarding small and medium-sized enterprises (SMEs) and their conditions in the present business environment, it is determinative for them to be prosperous and ambitious. In order to achieve their defined goals, such enterprises are advised to conduct periodical marketing environmental analyses and various audits. However, an audit process that examines overall enterprise management and measures its performance, i.e. management auditing, tends to be overlooked at times or mistaken for other activities. Related research involving Czech SMEs located in rural areas and operating in diverse industries discovered that management audit process capabilities, specifically in terms of organization and resources, are not fully utilized resulting in the enterprises’ lower competitiveness. In connection with broader assessment of enterprise management systems, the objective of this paper consists in introducing a particular sub-model titled “Comprehensive and Individual Resource Analysis”, which finalizes the previously developed and published “Two-Stage 7S Evaluation Model” [1]. Implementing the eventually completed model of management auditing on a regular basis would allow the SMEs to remove faults (and raise efficiencies) in their management processes, and enhance their enterprise value in the domestic and international markets.
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Sun, Wen Xiu, Tun Galag Dong, and Chun Ming Ding. "Crystal Structure Analysis and Antinociceptive Property of Lappaconitine Hydrochloride." Advanced Materials Research 343-344 (September 2011): 1049–52. http://dx.doi.org/10.4028/www.scientific.net/amr.343-344.1049.
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An alkaloid compound, lappaconitine Hydrochloride, was synthesized with lappaconitine which was isolated from the root ofAconitum sinomontanum Nakaiin Gansu province in China. The structures were elucidated by IR,NMR, Anal. and X-ray diffraction analysis. Crystal data: C32H47ClN2O9,Mr= 639.17, space group monoclinic, P21; a=10.665 (7) Å, b=12.178 (7) Å and c=12.214 (7) Å; β=91.003 (10)°, Z=2, Dx= 1.338 mg/m-3,F(000)= 684,µ=0.18.00 mm-1, V=1586.1 (16) Å3; R1=0.038,wR2=0.087, Flack parameter x= -0.12 (7). RingA, B, C, D, EandFrespectively present boat, chair, envelope, boat, boat and envelope forms. The absolute configuration was determined as 1S, 4S, 5S, 7S, 8S, 9S, 10S, 11S, 13R, 14S, 16S, 17 R. And the analgesic potential has been investigated in a mouse model of acute pain. The result exhibited that the analgesic effect of the compound is worse than lappaconitine hydrobromide.
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Bergamasco, R., DHS Horn, RH Nearn, and JS Wilkie. "Insect Moulting Hormones. LV. Experiments Directed Towards the Synthesis of Non-steroidal Ecdysone Analogues." Australian Journal of Chemistry 38, no. 3 (1985): 475. http://dx.doi.org/10.1071/ch9850475.
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Exploratory studies aimed at the synthesis of the non-steroidal ecdysone analogue (4aR,7S,8aR,-1′RS,4′R)-7-hydroxy-3-(1′-hydroxy-4′,8′- dimethylnonyl )-4a-methyl-4a,5,6,7,8,8a-hexahydronaphthal-en- 1(4H)-one (3) have led to in efficient method of joining the cyclic and side-chain synthons by reacting the vinylogous ester (4a) with 1-lithio-4,8-dimethyl-1,1-bis( methylthio ) nonane (12) to yield (4′RS)-3- [4′,8′-dimethyl-1′,1′-bis( methylthio ) nonyl ]-5,5-dimethylcyclohex-2-en-1-one (13). This thioacetal on reaction with boron trifluoride etherate and mercuric oxide afforded, quantitatively, the diketone (4′RS)-3-(4′,8′-dimethyl-1′-oxononyl)-5,5-dimethylcyclohex-2-en-1-one (14) which was selectively reduced in 85% yield to the required model compound (4′RS)-3-(1′-hydroxy-4′,8′-dimethylnonyl)-5,5-dimethylcyclohex-2-en-1-one (15).
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Nawaz, Malik Adil, Tanoj Kumar Singh, Regine Stockmann, Hema Jegasothy, and Roman Buckow. "Quality Attributes of Ultra-High Temperature-Treated Model Beverages Prepared with Faba Bean Protein Concentrates." Foods 10, no. 6 (May 30, 2021): 1244. http://dx.doi.org/10.3390/foods10061244.
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The objective of this research was to develop a model faba bean drink with a high concentration of protein (>4% w/w). The protein molecular weights and frequency for both faba and soy were assessed using SDS-PAGE. Results showed similarities in the protein molecular weight of both faba and soy (mainly 11S globulin ~Glycinin and 7S globulin ~β-conglycinin). Thus, faba can be considered as a potential soy replica in plant-based milk beverages. Oil-in-water emulsions (5–8% w/w available protein) were prepared using faba bean protein concentrate (FPC), 1% sunflower oil, and 0.2% sunflower lecithin. These emulsions were used as model beverages and were further investigated for UHT processibility, stability, and physicochemical properties. The physicochemical properties of emulsions at various processing stages viz., coarse emulsification, homogenisation, and UHT, were measured. An increase in the protein concentration and thermal treatment resulted in an increased oil droplet size, coalescence and flocculation, and protein aggregation. Lower protein concentrations viz., 5–6%, showed greater negative ζ-potential, and thereby, high dispersibility through enhanced electrostatic repulsions than those of higher concentrations (7–8%). Furthermore, an increase in protein concentration and UHT treatment resulted in an increased creaming index. In total, 21 different volatile compounds were detected and quantified, representing different chemical classes, namely alcohols, aldehydes, ketones, esters, furan, and acids. These volatiles have major consequences for the overall flavour chemistry of the model beverage product. Overall, this study showed the potential for application of faba bean as a protein source in UHT-treated legume-based beverages and identified areas for further development.
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Belyaev, Andrey K., and Svetlana A. Yakovleva. "Data on inelastic processes in low-energy collisions of barium atoms and ions with hydrogen atoms and anions." Monthly Notices of the Royal Astronomical Society 478, no. 3 (June 23, 2018): 3952–60. http://dx.doi.org/10.1093/mnras/sty1240.
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ABSTRACT Inelastic rate coefficients for 686 partial processes in low-energy Ba + H, Ba+ + H−, Ba++ H and Ba2+ + H− collisions are calculated. These data are needed for the non-local thermodynamic equilibrium (non-LTE) modelling of Ba i and Ba ii spectra, especially in cool stellar atmospheres. The calculations of the rate coefficients are performed by means of the quantum model approach, based on the asymptotic semi-empirical method for the electronic structure calculations and on multichannel formulas for the non-adiabatic nuclear dynamical calculations. The inelastic rate coefficients for all transitions between the 17 lowest covalent states and one ionic molecular state in Ba + H and Ba+ + H− collisions, as well as the inelastic rate coefficients for all transitions between the 19 lowest covalent states and one ionic molecular state in Ba+ + H and Ba2+ + H− collisions are calculated. In Ba+ + H− collisions, the highest rate coefficients correspond to the mutual neutralization processes into the Ba(6s6p1P°), Ba(6s7s3S) and Ba(6s7s1S) final states, with the largest value of 5.93 × 10−8 cm3 s−1 at T = 6000 K for the process Ba+ + H− → Ba(6s7s3S) + H. The highest rate coefficient for excitation and de-excitation processes in Ba + H collisions corresponds to the Ba(6s7s1S) → Ba(6s7s3S) transition, with the value of 7.62 × 10−9 cm3 s−1 at T = 6000 K. In Ba2+ + H− collisions, the highest rate coefficients correspond to the neutralization processes into the Ba+( 7p2P°), Ba+( 4f 2F°), Ba+( 6d 2D) and Ba+( 7s 2S) final states. The highest neutralization rate has the value of 3.96 × 10−8 cm3 s−1 at T = 6000 K for the Ba2+ + H− → Ba+( 7p 2P°) + H process. The largest rate coefficient for excitation and de-excitation processes in Ba+ + H collisions corresponds to the Ba+(7s 2S) → Ba+( 6p 2P°) transition, with the value of 1.23 × 10−9 cm3 s−1 at T = 6000 K.
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Zou, Yuan, Runting Pan, Qijun Ruan, Zhili Wan, Jian Guo, and Xiaoquan Yang. "Interaction of Soybean 7S Globulin Peptide with Cell Membrane Model via Isothermal Titration Calorimetry, Quartz Crystal Microbalance with Dissipation, and Langmuir Monolayer Study." Journal of Agricultural and Food Chemistry 66, no. 19 (April 10, 2018): 4913–22. http://dx.doi.org/10.1021/acs.jafc.8b00414.
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Sumardi, Sumardi. "Analisis Kualitas Pelayanan Transportasi Laut (Survei pada Perusahaan Pelayaran di Pelabuhan Tanjung Priok, 2015)." Majalah Ilmiah Bahari Jogja 18, no. 1 (March 2, 2020): 37–56. http://dx.doi.org/10.33489/mibj.v18i1.227.
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Penelitian ini bertujuan untuk menganalisis kualitas pelayanan transportasi laut Pelabuhan Tanjung Priok, Jakarta. Penelitian menggunakan metode SERVQUAL untuk mengukur kualitas pelayanan yang diterima pelanggan berdasarkan model kualitas pelayanan (gap model). SERVQUAL bertujuan untuk mengukur lima dimensi kualitas pelayanan yaitu: bukti fisik, keandalan, daya tanggap, jaminan, dan empati yang didasarkan pada analisis kesenjangan (gap analysis) antara harapan dan kinerja pelayanan. Penelitian menggunakan instrumen berupa kuesioner dengan melibatkan 91 perusahaan pelayaran yang diambil dengan teknik acak sederhana. Data penelitian selanjutnya dianalisis dengan analisis Servqual. Hasil penelitian menunjukkan bahwa secara umum kinerja pelayanan Pelabuhan Tanjung Priok dinilai perusahaan pelayaran cukup baik dan tingkat harapan pelayanan tergolong tinggi. Dimensi pelayanan yang dianggap paling penting adalah keandalan, bukti fisik, daya tanggap, jaminan dan empati. Untuk meningkatkan kualitas pelayanan terhadap perusahaan pelayaran, maka perlu melakukan perbaikan pelayanan dengan urutan prioritas: bukti fisik, keandalan, daya tanggap, jaminan, dan empati. Upaya perbaikan juga perlu mengacu pada hasil diagram kartesius, yaitu dengan berusaha mempertahankan atribut-atribut pelayanan pada kuadran B, meningkatkan perbaikan atribut pelayanan kuadran A, dan mengurangi upaya-upaya yang dilakukan terhadap atribut pelayanan pada kuadran C. selain itu, perlu juga dilakukan penelitian lebih lanjut tentang kualitas pelayanan dengan menggunakan dimensi kualitas pelayanan lain, seperti 7S dari McKinsey yang dianalisis dengan menggunakan pendekatan kualitatif.
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Yeandle, Jane, Liz Fawkes, Clare Carter, Chris Gordon, and Elizabeth Challis. "Organisational effectiveness and personality disorder." Mental Health Review Journal 20, no. 2 (June 8, 2015): 84–91. http://dx.doi.org/10.1108/mhrj-04-2014-0012.
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Purpose – National treatment guidelines regarding Borderline Personality Disorder (BPD) (National Institute for Health and Clinical Excellence, 2009) make a number of recommendations relating to system and cultural treatment variables including: access to services, autonomy and choice, developing an optimistic and trusting relationship and managing endings and transitions. The purpose of this paper is to look at a model which could help organisational effectiveness across a range of service settings in relation to personality disorder. Design/methodology/approach – Explanation of why the McKinsey 7S organisational model (Waterman et al., 1980) may be useful in assessing organisational effectiveness in relation to personality disorder. Findings – Cultural and organisational factors across a range of levels need to be aligned to allow for effective service delivery. This is particularly important in working with this client group where strong emotional reactions and subsequent organisational splits are common. Practical implications – The application of this tool within clinical leadership and service development would be particularly important for coherence within generalist (as opposed to specialist) settings. Originality/value – To the authors’ knowledge this analysis is unique as a review of NHS culture across a range of settings and discussion of the implications for service delivery for patients with BPD.
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Rosenfeldt, Anson B., Amanda L. Penko, Andrew S. Bazyk, Matthew C. Streicher, Tanujit Dey, and Jay L. Alberts. "The 2-Min Walk Test Detects Dual-Task Deficits in Individuals With Parkinson’s Disease." Journal of Aging and Physical Activity 27, no. 6 (December 1, 2019): 843–47. http://dx.doi.org/10.1123/japa.2018-0264.
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The aim of this project was to (a) evaluate the potential of the 2-min walk test to detect declines in gait velocity under dual-task conditions and (b) compare gait velocity overground and on a self-paced treadmill in Parkinson’s disease (PD). In total, 23 individuals with PD completed the 2-min walk test under single- and dual-task (serial 7s) conditions overground and on a self-paced treadmill. There was a significant decrease in gait velocity from single- to dual-task conditions overground (1.32 ± 0.22 to 1.10 ± 0.25 m/s; p < .001) and on the self-paced treadmill (1.24 ± 0.21 to 1.05 ± 0.25 m/s; p < .001). Overground and treadmill velocities were not statistically different from each other; however, differences approached or exceeded the minimal clinical important difference. The 2-min walk test coupled with a cognitive task provides an effective model of identifying dual-task declines in individuals with PD. Further studies comparing overground and self-paced treadmill velocity is warranted in PD.
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Ikhram, Faisal. "PENGEMBANGAN MANAJEMEN PERUBAHAN DALAM UPAYA MENINGKATKAN EFEKTIVITAS IMPLEMENTASI SISTEM INFORMASI AKADEMIK BERBASIS SIKA-ERP." Ekono Insentif 13, no. 1 (April 12, 2019): 27–40. http://dx.doi.org/10.36787/jei.v13i1.93.
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Salah satu sistem informasi di perguruan tinggi adalah sistem informasi akademik berbasis ERP yaitu sistem informasi terkomputerisasi yang tidak saja mencakup bisnis proses akademik tetapi juga terintegrasi dengan bisnis proses lainnya dalam pengelolaan institusi perguruan tinggi. Namun dalam praktiknya tidak sedikit institusi termasuk perguruan tinggi yang gagal mengimplementasikannya. Mengganti perangkat lunak dengan yang baru memungkinkan munculnya resistensi dari pengguna karena kekhawatiran berimplikasi mutasi, kehilangan pekerjaan, perampingan bahkan sampai pemutusan hubungan kerja. Oleh karena itu, diperlukan manajemen perubahan sebagai upaya mengubah sikap pengguna agar mau menggunakan sistem SIKA-ERP. Tujuan dari penelitian ini adalah untuk mengetahui kekuatan pendorong dan menghambat efektivitas implementasi SIKA-ERP dari aspek sikap pengguna. Hasil penelitian ini diharapkan menjadi masukan bagi policy maker dalam program perubahan di perguruan tinggi. Penelitian ini menggunakan metode kualitatif dan menggunakan model manajemen perubahan ADKAR dari Jeffrey M. Hiatt (Hiatt, 2006) dan menggunakan Kerangka McKinsey 7S untuk menanamkan nilai-nilai perubahan yang lebih baik dan menjadi budaya dalam organisasi. Dari diskusi kelompok forum dan wawancara mendalam disimpulkan bahwa implementasi SIKA-ERP di Perguruan Tinggi ini kurang efektif karena kurangnya kesadaran tenaga kependidikan sebagai pengguna bahwa perubahan telah menjadi prioritas bagi institusi.
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Munni, Afsana. "RETRACTED: Production and Characterization of Recombinant Rat Non-collagen Domain of α3 Chain of Type IV Collagen α3 (IV) NC1 Antigen." European Scientific Journal, ESJ 12, no. 24 (August 30, 2016): 98. http://dx.doi.org/10.19044/esj.2016.v12n24p98.
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Glomerulonephritis disease is characterized by inflammation of glomeruli or small blood vessels in the kidney which causes kidney diseases. Glomerulonephritis disease deposits the anti-GBM auto antibody in the glomerular basement membrane. The type IV collagen is the main component of glomerular basement membrane that has α3 chain of type (IV) collagen of non-collagenous domain which contains N-terminal 7S domain, a triple helical collagenous domain, and a C- terminal non-collagenous glomerular domain (NC1). The amino terminal of α3 (IV) NC1 that induces the experimental autoimmuno glomerulonephritis (EAG) in rat model has been identified. The recombinant rat α3 (IV)NC1 antigen has nine amino acid span that is consistent with antibody or T cell epitope which is induced in EAG. The research is carried out on the recombinant rat α3 (IV) NC1 production, purification, quantification, and characterization. The circulation of Anti-GBM antibody in glomerular basement membrane can be measured by the ELISA assay. In addition, the recombinant rat antigen is secreted in HEK293 cell supernatant which is purified by Anti-FLAG M2 monoclonal IgG antibody affinity column. In addition, it is characterized and quantified by SDS-PAGE gel electrophoresis and Western blotting techniques.
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Marzaman, Atika Puspita, and Wahyudin Hasan. "INKUBATOR BISNIS : STRATEGI UNTUK MENINGKATKAN KAPASITAS UKM BERBASIS MAKANAN DI KABUPATEN GORONTALO." AdBispreneur 5, no. 2 (December 9, 2020): 155. http://dx.doi.org/10.24198/adbispreneur.v5i2.28570.
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The purpose of this study was to analyze the capacity building of food-based SMEs through the incubator business model. The research method used is a qualitative method. Data collection was carried out through interviews, discussions and literature reviews. Furthermore, the collected data will be analyzed with the strengths, weaknesses, opportunities and challenges of developing an incubator business model for food-based SMEs in Gorontalo District. From this research it can be found that Gorontalo District has enormous food potential which should be accompanied by development of the downstream sector through food-based SMEs. The incubator business model with the Out Wall concept is an effective model that can be used to increase the capacity of food-based SMEs in Gorontalo District. Through this model, SMEs will receive incubation services at their respective locations which include 7S (space, shared office facilities, services, support, skills decelopment, seed capital and synergy). This incubation model is designed so that food-based SMEs will be able to map their potential and develop businesses which in turn will have a positive impact on regional economic development. Tujuan penelitian ini adalah untuk mengkaji mengenai peningkatan kapasitas UKM berbasis makanan melalui pengembangan model inkubator bisnis. Metode penelitian yang digunakan adalah metode kualitatif. Pengumpulan data dilakukan melalui wawancara, diskusi dan kajian pustaka. Selanjutnya, data yang terkumpul akan dianalisis dengan menelusuri keunggulan, kelemahan, peluang dan tantangan pengembangan model inkubator bisnis untuk UKM berbasis makanan di Kabupaten Gorontalo. Dari penelitian ini dapat diperoleh bahwa Kabupaten Gorontalo memiliki potensi pangan yang sangat besar yang sepatutnya diiringi dengan pengembangan sektor hilir melalui UKM berbasis makanan. Model inkubator bisnis dengan konsep Out Wall merupakan salah satu model efektif yang dapat digunakan untuk meningkatkan kapasitas UKM berbasis bahan pangan di Kabupaten Gorontalo. Melalui model ini, UKM akan memperoleh layanan inkubasi di lokasinya masing-masing yang mencakup 7 S (space, shared office facilities, service, support, skill decelopment, seed capital dan sinergy). Model inkubasi ini dirancang agar UKM berbasis makanan akan mampu memetakan potensi dan mengembangkan bisnis yang selanjutnya akan berdampak positif bagi pengembangan ekonomi daerah.
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Chow, Jeng-Yeong, Bo-Xue Tian, Gurusankar Ramamoorthy, Brandan S. Hillerich, Ronald D. Seidel, Steven C. Almo, Matthew P. Jacobson, and C. Dale Poulter. "Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus." Proceedings of the National Academy of Sciences 112, no. 18 (April 21, 2015): 5661–66. http://dx.doi.org/10.1073/pnas.1505127112.
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Terpenoids are a large structurally diverse group of natural products with an array of functions in their hosts. The large amount of genomic information from recent sequencing efforts provides opportunities and challenges for the functional assignment of terpene synthases that construct the carbon skeletons of these compounds. Inferring function from the sequence and/or structure of these enzymes is not trivial because of the large number of possible reaction channels and products. We tackle this problem by developing an algorithm to enumerate possible carbocations derived from the farnesyl cation, the first reactive intermediate of the substrate, and evaluating their steric and electrostatic compatibility with the active site. The homology model of a putative pentalenene synthase (Uniprot: B5GLM7) from Streptomyces clavuligerus was used in an automated computational workflow for product prediction. Surprisingly, the workflow predicted a linear triquinane scaffold as the top product skeleton for B5GLM7. Biochemical characterization of B5GLM7 reveals the major product as (5S,7S,10R,11S)-cucumene, a sesquiterpene with a linear triquinane scaffold. To our knowledge, this is the first documentation of a terpene synthase involved in the synthesis of a linear triquinane. The success of our prediction for B5GLM7 suggests that this approach can be used to facilitate the functional assignment of novel terpene synthases.
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Polyanska, Alla, Ivanna Zapukhliak, and Oksana Diuk. "Culture of organization in conditions of changes as an ability of efficient transformations: the case of gas transportation companies in Ukraine." Oeconomia Copernicana 10, no. 3 (September 30, 2019): 561–80. http://dx.doi.org/10.24136/oc.2019.027.
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Research background: The relevance of the research on corporate culture in the conditions of changes is substantiated and its elements, which are important for effective transformations, are defined. The influence of corporate culture on the company performance and its elements is identified. The article deals with hierarchical levels of corporate culture which identify elements of corporate culture and "hidden" factors that allow establishing relationships with the outside world and promote productive work.
Purpose of the article: The objective of the article is to identify the elements of the organizational culture at the enterprise level, which influence the effectiveness of its activities under the changes and generalization of its components that determine its ability to transform the existing state in accordance with the established world experience and practice. The research is based on the experience of gas transportation companies in Ukraine.
Methods: The McKinsey 7S model was used to describe the enterprise to assess the state of the proposed levels of formation and to change its corporate culture. The McKinsey 7S Framework used in this study as analytical tool to explore a system of interrelated elements which improve the organization's work, raising the level of employee culture and generating common values. The expert method was used to assess the qualitative indices of enterprise internal environment, including "style/culture" and "common values", based on the questionnaire of the experts' group. The survey was conducted at three levels of management for the gas transportation companies, located in different regions of Ukraine. The three levels of management for the mentioned above enterprises — top, middle and low managers were taken into account. The use of the fuzzy logic method makes it possible to investigate the influence of the corporate culture elements on the results of the enterprises and to identify those elements which are important for the implementation of changes at the enterprise and without which it is impossible to achieve effective transformations.
Findings & Value added: Taking into account the results of the assessment of corporate culture elements at the investigated companies, the directions of corporate culture development for enterprises that are in a state of changes are pointed out, namely: use of different management styles; support of employees in making innovative decisions; development of cooperation and elimination of conflicts between workers; formation of general corporate values; creating trust between employees and top managers; promoting the development of young workers; use of the mechanisms of education and maintenance of a high level of morality and culture of workers.
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Suou, Takeaki, Sadako Yamada, Junko Kobayashi, Ushio Hoshino, Eiji Nishimuki, and Hironaka Kawasaki. "Changes of serum 7S fragment of type IV collagen andN-terminal propeptide of type III procollagen after transcatheter arterial embolization as a model of acute liver injury." Hepatology 18, no. 4 (October 1993): 809–15. http://dx.doi.org/10.1002/hep.1840180410.
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Chris Simon, Kipkorir Sitienei, and Daniel Kipkorir Ronoh. "Strategy Implementation and Performance of Non Governmental Organizations in Kericho County, Kenya." Management and Organizational Studies 4, no. 3 (July 27, 2017): 34. http://dx.doi.org/10.5430/mos.v4n3p34.
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Non-Governmental Organizations face problems related to planning, staffing, organizational change, influence ofleadership on allocation of resource and competition. The study focused on strategy implementation and performance.The objectives were; to investigate the effect of resource allocation, role of staff involvement, influence of rewardsystems, effect of operating procedures and role of communication on performance. The study is important toNon-Governmental Organizations, board of directors, donors and government. The study used McKinsey 7s model,survey research design. The target population was 37 the organizations and 349 members of the management team.Stratified technique was used to categorize the management into Board of Governors, managing directors, managersand heads of departments/project officers. A sample size of 151 respondents was selected from the categories. Datawas collected and analyzed using descriptive and inferential statistics with the aid of Statistical Package for SocialSciences (SPSS) version 21. The analyzed data was presented in form of frequency distribution tables. The findingsindicated that Strategy operationalization through resource allocation (allocation of money, adequate personnel andstaff involvement to implement new strategies) and operating procedures (staff training, policies, guiding principlesto ensure compliance to organization’s strategy, procedures, capacity of management, strategic guidance of topmanagement) affect performance to varying levels , Strategy institutionalization, through communication and rewardsystem (clear goals and objectives, strategy direction, strategy clearly communicated, performance recognitionsystem, effort based rewards and rewards system linked to new strategy affect performance differently.
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Tonomura, Shuichi, Shuhei Naka, Keiko Tabata, Tasuku Hara, Kojiro Mori, Saiyu Tanaka, Yoshio Sumida, et al. "Relationship between Streptococcus mutans expressing Cnm in the oral cavity and non-alcoholic steatohepatitis: a pilot study." BMJ Open Gastroenterology 6, no. 1 (October 2019): e000329. http://dx.doi.org/10.1136/bmjgast-2019-000329.
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BackgroundNon-alcoholic steatohepatitis (NASH) is a severe state of non-alcoholic fatty liver disease (NAFLD), which is pathologically characterised by steatosis, hepatocyte ballooning, and lobular inflammation. Host–microbial interaction has gained attention as one of the risk factors for NASH. Recently, cnm-gene positive Streptococcus mutans expressing cell surface collagen-binding protein, Cnm (cnm-positive S. mutans), was shown to aggravate NASH in model mice. Here, we assessed the detection rate of cnm-positive S. mutans in oral samples from patients with NASH among NAFLD.MethodsThis single hospital cohort study included 41 patients with NAFLD. NASH was diagnosed histologically or by clinical score. The prevalence of cnm-positive S. mutans, oral hygiene and blood tests, including liver enzymes, adipocytokines and inflammatory and fibrosis markers, were assessed in biopsy-proven or clinically suspected NASH among NAFLD.ResultsPrevalence of cnm-positive S. mutans was significantly higher in patients with NASH than patients without NASH (OR 3.8; 95% CI 1.02 to 15.5). The cnm-positive S. mutans was related to decreased numbers of naturally remaining teeth and increased type IV collagen 7S level (median (IQR) 10.0 (5.0–17.5) vs 20.0 (5.0–25.0), p=0.06; 5.1 (4.0–7.9) vs 4.4 (3.7–5.3), p=0.13, respectively).ConclusionsPrevalence of cnm-positive S. mutans in the oral cavity could be related to fibrosis of NASH among NAFLD.
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Nasreen, Reshma, Sadaf Siraj, and Sana Beg. "Fast Trax – the Indian QSR chain." Emerald Emerging Markets Case Studies 2, no. 8 (October 17, 2012): 1–14. http://dx.doi.org/10.1108/20450621211289403.
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Subject area Services marketing and marketing strategy. Study level/applicability The case is basically aimed at post-graduate management students; it can be used in strategic management courses. Students can understand McKinsey's 7S model with the help of this case as well as the seven Ps of service industry. Students can also gain an insight into the hub and spoke model. The case can also be used in courses of entrepreneurship. Case overview The case is primarily the entrepreneurial journey of Mr Samar Qureshi in a quick service restaurant business. The entrepreneur Mr Samar Qureshi at a very young age dreamt of opening up an Indian fast food chain. He worked hard to make his dream a reality. In a brief period of five years Qureshi's Fast Trax has reached the level of world-renowned fast food chains like McDonald's and KFC in terms of quality and ambience. Overcoming the hurdles and the challenges Fast Trax has 22 outlets in Delhi NCR. Samar has also introduced the fast food culture in a small town, Aligarh, and wishes to expand it further to other B class towns of India where people desire to go to fast food chains and to enjoy the high standards of food and service as are enjoyed by people living in metros. He has also been instrumental in changing the concept of canteen to restaurant in schools and colleges. The case discusses the challenges facing Fast Trax in the cut-throat environment of the fast food industry. Expected learning outcomes These include: highlighting the 7Ps of services in the context of a retail chain and establishing interlinkages between the seven Ss identified by McKinsey. Supplementary materials Teaching notes are available. Please consult your librarian for access.
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Chia, Yen Lin, Ute Hoch, Abraham C. F. Leung, and Michael A. Eldon. "NKTR-102 in patients with platinum-resistant ovarian cancer (PROC): Modeling CA125 response and its correlation with tumor response." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 5048. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.5048.
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5048 Background: NKTR-102 is a unique topoisomerase 1 inhibitor that provides continuous exposure to SN38. In heavily pretreated pts with PROC (median of 3 prior therapies; 27 pts were platinum refractory), 145 mg/m2 NKTR-102 given q14d or q21d demonstrated significant anti-tumor activity (JCO 28:7s, 5013). We present a PK/PD model for CA125 kinetics that can be used to project GCIG response as an aide to selecting dose and schedule. Methods: Data from 55 pts with PROC and elevated CA125 (median baseline = 515 U/mL) were fit with a PK/PD model developed to correlate CA125 dynamics with SN38 conc-time profiles predicted from individual pt dosing history: d[CA125]/dt = Kin*exp(beta*t)*(1-[SN38]/(IC50+[SN38]))-Kout*[CA125]. Results: CA125 profiles were well described by the model, with a population mean SN38 IC50 of 1.1 ng/mL. Typical min and max SN38 conc during treatment were 1.5 and 3 ng/mL for q14d and 0.9 and 2.4 ng/mL for q21d, indicating that both schedules resulted in SN38 exposure near the IC50. The half-life of CA125 decline was 6.4 days, similar to literature values. 46 of 55 pts had pre- and post-treatment tumor measurements for correlation of CA125 response and tumor size. Overall best response by GCIG and RECIST correlated in 57% of pts. 33% of pts with GCIG response showed declines in tumor size, albeit insufficient to classify as RECIST response. 72% of pts with GCIG SD showed at least SD by RECIST. CA125 vs time was simulated for 1000 pts receiving 145 mg/m2 NKTR-102 q14d or q21d, to allow comparison of CA125 and GCIG response between schedules (see table). The % pts per GCIG response was comparable between schedules, supporting use of the better-tolerated q21d regimen. Conclusions: The PK/PD model described CA125 profiles well, providing a tool to predict drug response from SN38 PK data. Close correlation of CA125 with tumor size is consistent with historical use of CA125 as a surrogate marker. Predicted CA125 profiles for NKTR-102 q14d or q21d were similar, suggesting that the better-tolerated q21d schedule will produce results consistent with those from Ph 2. [Table: see text]
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Arao, Hiroshi, and Jiro Gyoba. "Disruptive Effects in Chord Priming." Music Perception 17, no. 2 (1999): 241–45. http://dx.doi.org/10.2307/40285893.
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Chord-priming effects were investigated in a related-prime condition, an unrelated-prime condition, and a control condition in which a noise was presented instead of a prime chord. Ten participants listened to a sequence consisting of a prime (a chord or a noise) and a target chord and then decided whether the target chord was in tune or out of tune. The interonset intervals between the prime and target chords were varied at either 1, 3, or 7 s, whereas the duration of the chords or noises was fixed at 500 ms. Responses were significantly slower with lower accuracy in the unrelated-prime condition than in the control condition, whereas responses were not significantly faster in the related-prime condition than in the control condition. The delay in the unrelated-prime condition was found at interonset intervals of 1 and 3 s, but the delay almost disappeared at the longest interonset interval of 7 s. These results cannot be fully explained by a spreading activation model that assumes a facilitation effect, but rather seem to suggest that disruptive effects occur with regard to the sensitivity to chordal tuning. /// 和音プライミング効果を，関連プライム条件，非関連プライム条件，統制条 件において検討した. 統制条件においては，プライム和音のかわりにノイズ が呈示された. 10名の被験者は，プライム (和音またはノイズ) とターゲッ ト和音を聞き，ターゲット和音のチューニングが正しいか誤っているかを判 断した. プライムとターゲット和音の立ち上がり聞の時間間隔は, 1，3， 7sのいずれかであり，和音とノイズの長さはすべて500msであった. 非関連 プライム条件における反応は, 統制条件における反応よりも有意に遅く，正 答率も低かった. 一方，関連プライム条件における反応は，統制条件におけ る反応よめも有意差がみられるほど速くはなかった. 非関連プライム条件に おける反応の遅れは，時間間隔が1, 3sのときにあらわれたが. 7sのとき にはほとんど消失した. これらの結果は，和音のチューニング感度に妨害効 果が生じていることを示唆しており，促進効果を仮定する活性化拡散モデル では完全には説明できない.
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Sobhani, Iradj, Amine Ghozelane, Emma Bergsten Bergsten, and Sean Kennedy. "Microbiota as a new indicator of colorectal cancer (CRC) heterogeneity." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 3615. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.3615.
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3615 Background: Location and somatic gene signature of CRCs may impact prognosis and therapy response. The aim was to characterize colon Microbiota in CRC patients regarding location, gene markers and outcome. Methods: Patients (N = 173) signed consent for whole metagenome (shot gun sequencing on Illumina HiSeq2500) analysis of stool DNA: 72 CRC (53 sporadic-S, 19 Lynch-L), 87 asymptomatic subjects (normal colonoscopy), 14 first degree healthy relatives from Lynch families. "MOCAT" pipeline was used, library sorted (Phred quality score ¡20 Alientrimmer v0.4.0) after exclusion of < 35 nt, human genes or phage sequences. Quality sequences were aligned (REFMG.V13) and most abundant genes constructed (MBMA program v0.1). The Shaman program (shaman.c3bi.pasteur.fr) was used. The number of bacteria was estimated (REFMG program). The linear model (GLM) was implemented in the DESeq2 R kit. Dfferences between Control (N = 87) and CRCs (N = 69), between L (N = 19) and S CRCs(N = 50), and between LCRC (N = 19) and Healthy Lynch relatives were obtained after interaction of age, BMI and gender was considered (GLM model). The P < 0.1 value was retained after correction (Benjamini and Hochberg). The specific taxonomic composition of the control and CRC groups was subjected to random analysis ( Caret's R package) with two optimization parameters (precision and kappa) in the model. Results: There was no difference for gender, age (p = 0.08) and BMI (p = 0.187) in the L and S CRCs. Significant differences were observed between Normal and CRCs, C-CRC and L-CRC, L-CRC and first degree relatives based on the common component (similarity of sequences): 13 species differentiated Normal and CCRs, two were more prevalent in L-CRCs. The panels of bacteria linked with location, MSI, Ras mutations, methylation phenotypes and survival were identified. No significant link was observed with TNM Staging: I (N = 17, 2L and 15S), II (N = 12, 5L and 7S), III (N = 20, 10L, 10S), IV (N = 22.1L, 21S). DFS might be dysbiosis dependent. Conclusions: CRC dysbiosis is location-dependent. Several bacteria are associated with Ras mutation, MSI, and methylation status. They may directly or through therapies impact the prognosis. Microbiota signature should be taken in consideration in trials.
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Szymak, Piotr, Paweł Piskur, Jacek Goszczyński, and Tomislav Batur. "Measurement Of The Dynamics Of The Sheave Block Of Shipyard Crane With 1000 T Lifting Capacity For Verification Of The Laboratory Stand." Pedagogika-Pedagogy 93, no. 7s (August 31, 2021): 96–109. http://dx.doi.org/10.53656/ped21-7s.08meas.
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The paper includes partial results of the development project entitled “The first Polish gantry crane with high lifting capacity for the shipbuilding industry adapted to work in difficult wind conditions – development and demonstration” (no POIR.01.02.00-00-0017/18). Due to the requirements of working in challenging wind conditions, the crane will be equipped with the sheave block with a hook operating automatically. To resolve this problem, mathematical and then physical models of the innovative crane are required. Therefore, to obtain reliable models, the measurement of the dynamics of the sheave block of crane with high lifting capacity was carried out. At the beginning of the paper, the conditions and used measurement stand are included. Then, the time and frequency analysis of the received measurement results are described. Moreover, the determination of the crane parameters is also presented. The analysis results will be used in further research to tune both the simulation and the physical models of the crane with an automatic hook, which are being developed.