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Journal articles on the topic 'Model informed approach'

Author: Grafiati

Published: 29 June 2021

Last updated: 9 February 2022

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1

Vorobiev, Oleg, Eric Herbold, Souheil Ezzedine, and Tarabay Antoun. "A continuum model for concrete informed by mesoscale studies." International Journal of Damage Mechanics 27, no. 10 (2017): 1451–81. http://dx.doi.org/10.1177/1056789517730884.

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The paper describes a novel computational approach to refine continuum models for penetration calculations which involves two stages. At the first stage, a trial continuum model is used to model penetration into a concrete target. Model parameters are chosen to match experimental data on penetration depth. Deformation histories are recorded at few locations in the target around the penetrator. In the second stage, these histories are applied to the boundaries of a representative volume comparable to the element size in large scale penetration simulation. Discrete-continuum approach is used to

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Madabushi, Rajanikanth, Yaning Wang, and Issam Zineh. "A Holistic and Integrative Approach for Advancing Model‐Informed Drug Development." CPT: Pharmacometrics & Systems Pharmacology 8, no. 1 (2019): 9–11. http://dx.doi.org/10.1002/psp4.12379.

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Hughes, Hilary, Marcus Foth, and Kerry Mallan. "Social living labs for informed learning." Journal of Information Literacy 13, no. 2 (2019): 112. http://dx.doi.org/10.11645/13.2.2641.

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This paper proposes social living labs for informed learning as an innovative approach to interprofessional and community education. It presents a new conceptual model and practice framework suited to rapidly changing, information-intensive work and social environments. The proposed approach is theoretically informed and evidence based. It integrates concepts from three complementary fields: Informed learning as information literacy pedagogy that enables using information critically and creatively to learn (information science); interprofessional education as a professional learning model with

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Koury, Samantha P., and Susan A. Green. "Developing Trauma-Informed Care Champions: A Six-Month Learning Collaborative Training Model." Advances in Social Work 18, no. 1 (2017): 145–66. http://dx.doi.org/10.18060/21303.

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This paper describes a six-month learning collaborative for service providers seeking to implement trauma-informed care (TIC) into their agencies. Although the professional literature on trauma-informed care has grown substantially over the past 10 years, little research has focused on how to effectively train agencies in creating a trauma-informed culture shift. Participants were trained as “TIC champions” to help facilitate the creation of trauma-informed approaches in their agencies. Through a parallel process, they learned the skills for planning and implementing a trauma-informed approach

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Wind, Stefanie A., and A. Adrienne Walker. "A Model‐Data‐Fit‐Informed Approach to Score Resolution in Performance Assessments." Educational Measurement: Issues and Practice 40, no. 3 (2021): 52–63. http://dx.doi.org/10.1111/emip.12427.

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Montgomery, Jacob M., Santiago Olivella, Joshua D. Potter, and Brian F. Crisp. "An Informed Forensics Approach to Detecting Vote Irregularities." Political Analysis 23, no. 4 (2015): 488–505. http://dx.doi.org/10.1093/pan/mpv023.

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Electoral forensics involves examining election results for anomalies to efficiently identify patterns indicative of electoral irregularities. However, there is disagreement about which, if any, forensics tool is most effective at identifying fraud, and there is no method for integrating multiple tools. Moreover, forensic efforts have failed to systematically take advantage of country-specific details that might aid in diagnosing fraud. We deploy a Bayesian additive regression trees (BART) model–a machine-learning technique–on a large cross-national data set to explore the dense network of pot

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Miller, Faye Q. "Experiencing information use for early career academics’ learning: a knowledge ecosystem model." Journal of Documentation 71, no. 6 (2015): 1228–49. http://dx.doi.org/10.1108/jd-04-2014-0058.

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Purpose – The purpose of this paper is to explore the informed learning experiences of early career academics (ECAs) while building their networks for professional and personal development. The notion that information and learning are inextricably linked via the concept of “informed learning” is used as a conceptual framework to gain a clearer picture of what informs ECAs while they learn and how they experience using that which informs their learning within this complex practice: to build, maintain and utilise their developmental networks. Design/methodology/approach – This research employs a

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Khoshkholgh, Sarouyeh, Andrea Zunino, and Klaus Mosegaard. "Informed proposal Monte Carlo." Geophysical Journal International 226, no. 2 (2021): 1239–48. http://dx.doi.org/10.1093/gji/ggab173.

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SUMMARY Any search or sampling algorithm for solution of inverse problems needs guidance to be efficient. Many algorithms collect and apply information about the problem on the fly, and much improvement has been made in this way. However, as a consequence of the No-Free-Lunch Theorem, the only way we can ensure a significantly better performance of search and sampling algorithms is to build in as much external information about the problem as possible. In the special case of Markov Chain Monte Carlo (MCMC) sampling we review how this is done through the choice of proposal distribution, and we

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Jongejan, Ruben, Roshanka Ranasinghe, and Han Vrijling. "A RISK-INFORMED APPROACH TO COASTAL ZONE MANAGEMENT." Coastal Engineering Proceedings 1, no. 32 (2011): 8. http://dx.doi.org/10.9753/icce.v32.management.8.

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Economic and population growth have led to an unprecedented increase in the value at risk in coastal zones over the last century. To avoid excessive future losses, particularly in the light of projected climate change impacts, coastal zone managers have various instruments at their disposal. These primarily concern land-use planning (establishing buffer zones) and engineering solutions (beach nourishment and coastal protection). In this paper, we focus on risk mitigation through the implementation of buffer zones (setback lines). Foregoing land-use opportunities in coastal regions and protecti

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Li, Jerry, Mina Nikanjam, Coleen K. Cunningham, et al. "Model Informed Development of VRC01 in Newborn Infants Using a Population Pharmacokinetics Approach." Clinical Pharmacology & Therapeutics 109, no. 1 (2020): 184–92. http://dx.doi.org/10.1002/cpt.2026.

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Ryu, Doojin. "INFORMATION CONTENT OF INTER-TRANSACTION TIME: A STRUCTURAL APPROACH." Journal of Business Economics and Management 16, no. 4 (2015): 697–711. http://dx.doi.org/10.3846/16111699.2013.804873.

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This study examines the information role of inter-transaction time by employing a structural market microstructure model. By analyzing the intraday data of the KOSPI200 futures market, we find that the inter-transaction time (i.e., time between two consecu- tive trades) reveals significant information, and that fast trading is indicative of informed trading. This result remains robust when the effect of trade size is incorporated into the model. Our regression analysis indicates that the information role of inter-transaction time becomes more important when informed trading is less concentrate

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Mahon, Daryl. "Trauma-informed servant leadership in health and social care settings." Mental Health and Social Inclusion 25, no. 3 (2021): 306–20. http://dx.doi.org/10.1108/mhsi-05-2021-0023.

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Purpose Practitioners, organisations and policy makers in health and social care settings are increasingly recognising the need for trauma-informed approaches in organisational settings, with morbidity and financial burdens a growing concern over the past few years. Servant leadership has a unique focus on emotional healing, service to others as the first priority, in addition to the growth, well-being and personal and professional development of key stakeholders. This paper aims to discuss Trauma Informed Servant Leadership (TISL). Design/methodology/approach A targeted review of the servant

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Su, Ke. "A Research on the Informed Tectonics Design Model Based on Material." Applied Mechanics and Materials 556-562 (May 2014): 4211–13. http://dx.doi.org/10.4028/www.scientific.net/amm.556-562.4211.

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The institutionalized separation between form, structure and material, deeply embedded in modernist design theory. This research proposes a model based on informed tectonics for a material-based approach enabled form-generation. Based on the analysis of user demand, this thesis develops a way to build up user demand model based on user preference. This model gives some reference to the development of product innovation.

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Dodds, Michael, Yuan Xiong, Samer Mouksassi, et al. "Model‐informed drug repurposing: A pharmacometric approach to novel pathogen preparedness, response and retrospection." British Journal of Clinical Pharmacology 87, no. 9 (2021): 3388–97. http://dx.doi.org/10.1111/bcp.14760.

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Kataoka, Sheryl H., Pamela Vona, Alejandra Acuna, et al. "Applying a Trauma Informed School Systems Approach: Examples from School Community-Academic Partnerships." Ethnicity & Disease 28, Supp (2018): 417–26. http://dx.doi.org/10.18865/ed.28.s2.417.

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Objectives: Schools can play an important role in addressing the effects of traumatic stress on students by providing prevention, early intervention, and intensive treatment for children exposed to trauma. This article aims to describe key domains for implementing trauma-informed practices in schools.Design: The Substance Abuse and Mental Health Administration (SAMHSA) has identified trauma-informed domains and principles for use across systems of care. This article applies these domains to schools and presents a model for a Trauma-Informed School System that highlights broad macro level f

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Crenshaw, David A. "An Interpersonal Neurobiological-Informed Treatment Model for Childhood Traumatic Grief." OMEGA - Journal of Death and Dying 54, no. 4 (2007): 319–35. http://dx.doi.org/10.2190/b115-5526-0u27-4296.

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This article expands an earlier model of the tasks of grieving (1990, [1995], [2001]) by building on science based findings derived from research in attachment theory, neuroscience, interpersonal neurobiology, and childhood traumatic grief (CTG). The proposed treatment model is a prescriptive approach that spells out specific tasks to be undertaken by children suffering traumatic grief under the direction of a therapist who is trained in trauma-informed therapy approaches and draws heavily on the empirically derived childhood traumatic grief treatment model developed by Cohen and Mannarino (20

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Klingmüller, Klaus, and Jos Lelieveld. "Climate-model-informed deep learning of global soil moisture distribution." Geoscientific Model Development 14, no. 7 (2021): 4429–41. http://dx.doi.org/10.5194/gmd-14-4429-2021.

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Abstract. We present a deep neural network (DNN) that produces accurate predictions of observed surface soil moisture, applying meteorological data from a climate model. The network was trained on daily satellite retrievals of soil moisture from the European Space Agency (ESA) Climate Change Initiative (CCI). The predictors precipitation, temperature and humidity were simulated with the ECHAM/MESSy atmospheric chemistry–climate model (EMAC). Our evaluation shows that predictions of the trained DNN are highly correlated with the observations, both spatially and temporally, and free of bias. Thi

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Somerville, Mary M., and Niki Chatzipanagiotou. "Informed Systems: Enabling Collaborative Evidence Based Organizational Learning." Evidence Based Library and Information Practice 10, no. 4 (2015): 24. http://dx.doi.org/10.18438/b8vp4x.

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Abstract  Objective – In response to unrelenting disruptions in academic publishing and higher education ecosystems, the Informed Systems approach supports evidence based professional activities to make decisions and take actions. This conceptual paper presents two core models, Informed Systems Leadership Model and Collaborative Evidence-Based Information Process Model, whereby co-workers learn to make informed decisions by identifying the decisions to be made and the information required for those decisions. This is accomplished through collaborative design and iterative evaluatio

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Herath, Herath Mudiyanselage Viraj Vidura, Jayashree Chadalawada, and Vladan Babovic. "Hydrologically informed machine learning for rainfall–runoff modelling: towards distributed modelling." Hydrology and Earth System Sciences 25, no. 8 (2021): 4373–401. http://dx.doi.org/10.5194/hess-25-4373-2021.

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Abstract. Despite showing great success of applications in many commercial fields, machine learning and data science models generally show limited success in many scientific fields, including hydrology (Karpatne et al., 2017). The approach is often criticized for its lack of interpretability and physical consistency. This has led to the emergence of new modelling paradigms, such as theory-guided data science (TGDS) and physics-informed machine learning. The motivation behind such approaches is to improve the physical meaningfulness of machine learning models by blending existing scientific kno

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Soltani, Payam, Christophe Pinna, David J. Wagg, and Roly Whear. "Ageing simulation of a hydraulic engine mount: A data-informed finite element approach." Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 233, no. 10 (2018): 2432–42. http://dx.doi.org/10.1177/0954407018786147.

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Hydraulic engine mounts are key elements in an automotive vehicle suspension system that typically experience a change of their designed function during their working lifetime due to progressive material ageing, primarily from the elastomeric component. Ageing of the engine mount, resulting from severe and continuous mechanical and thermal loads, can have a detrimental impact on the ride and comfort and long-term customer satisfaction. This paper introduces a new practical methodology for simulating the ageing behaviour of engine mounts resulting from the change in properties of their elastome

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Mantler, Tara, and Barat Wolfe. "Evaluation of Trauma-Informed Integrated Health Models of Care for Women: A Qualitative Case Study Approach." Partner Abuse 9, no. 2 (2018): 118–36. http://dx.doi.org/10.1891/1946-6560.9.2.118.

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For victims of partner abuse and trauma in Southwestern Ontario, unique options are available showcasing integrated models of trauma-informed care between social service agencies and primary health-care providers; however, little formal evaluation of these integration models has been completed. The purpose of this multiple case study approach is to examine the acceptability and perceived impacts of two models of trauma-informed social and primary care services, and identify gaps and recommendations for improving the quality of services offered to marginalized women. Participants were recruited

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GAUTHIER, LAURENT. "INFORMED OPPORTUNISTIC TRADING AND PRICE OPTIMAL CONTROL." International Journal of Theoretical and Applied Finance 06, no. 01 (2003): 31–55. http://dx.doi.org/10.1142/s0219024903001773.

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In this paper we focus on the incentive to invest or disinvest in equity shares to benefit from discrepancies between their real value and their market prices, based on privileged information. Such a situation arises in particular when a manager trades his company's own stock. An existing simple model for the impact of transactions on prices is extended to the case of discrete transactions. This model is used to represent the impact of the informed agent's transactions. A probabilistic approach is proposed to determine the optimal control applied to the market price by the informed agent. Anal

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Gomeni, Roberto, Jonathan Rabinowitz, Navin Goyal, Françoise Marie Madeleine Bressolle‐Gomeni, and Maurizio Fava. "Model‐Informed Approach to Assess the Treatment Effect Conditional to the Level of Placebo Response." Clinical Pharmacology & Therapeutics 106, no. 6 (2019): 1253–60. http://dx.doi.org/10.1002/cpt.1584.

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Susanto, Budi O., Sebastian G. Wicha, Yanmin Hu, Anthony R. M. Coates, and Ulrika S. H. Simonsson. "Translational Model‐Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development." Clinical Pharmacology & Therapeutics 108, no. 2 (2020): 274–86. http://dx.doi.org/10.1002/cpt.1814.

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Tao, Hai, Jing Wang, Zaher Mundher Yaseen, Muamer N. Mohammed, and Jasni Mohamad Zain. "Shrewd vehicle framework model with a streamlined informed approach for green transportation in smart cities." Environmental Impact Assessment Review 87 (March 2021): 106542. http://dx.doi.org/10.1016/j.eiar.2020.106542.

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Murray, Ann M., Ashley B. Petrone, and Amelia K. Adcock. "Utilization of a Parental Approach to Informed Consent in Intravenous Tissue Plasminogen Activator Administration Decision-Making: Patient Preference and Ethical Considerations." Neurology Research International 2019 (September 5, 2019): 1–4. http://dx.doi.org/10.1155/2019/9240603.

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Objective. While administration of intravenous tissue plasminogen activator (IV-tPA) is the standard of care in acute ischemic stroke and has been shown to have statistically significant benefit, there can also be potentially life-threatening complications; however, there is no standard informed consent approach. The purpose of this study was to present a parental, technical, and general model of informed consent for IV-TPA and to determine which approach was preferred. Methods. Survey respondents were asked to hypothetically decide whether or not to provide consent for their family member to

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Uster, David W., Sophie L. Stocker, Jane E. Carland, et al. "A Model Averaging/Selection Approach Improves the Predictive Performance of Model‐Informed Precision Dosing: Vancomycin as a Case Study." Clinical Pharmacology & Therapeutics 109, no. 1 (2020): 175–83. http://dx.doi.org/10.1002/cpt.2065.

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Melillo, Nicola, and Adam S. Darwich. "A latent variable approach to account for correlated inputs in global sensitivity analysis." Journal of Pharmacokinetics and Pharmacodynamics 48, no. 5 (2021): 671–86. http://dx.doi.org/10.1007/s10928-021-09764-x.

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AbstractIn drug development decision-making is often supported through model-based methods, such as physiologically-based pharmacokinetics (PBPK). Global sensitivity analysis (GSA) is gaining use for quality assessment of model-informed inference. However, the inclusion and interpretation of correlated factors in GSA has proven an issue. Here we developed and evaluated a latent variable approach for dealing with correlated factors in GSA. An approach was developed that describes the correlation between two model inputs through the causal relationship of three independent factors: the latent va

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Sprang, Ginny, Leslie Anne Ross, and Brian Miller. "A data-driven, implementation-focused, organizational change approach to addressing secondary traumatic stress." European Journal for Person Centered Healthcare 6, no. 1 (2018): 62. http://dx.doi.org/10.5750/ejpch.v6i1.1400.

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The literature is replete with examples of the heavy toll that Secondary Traumatic Stress (STS) exacts among the workers who assist trauma survivors. The subsequent impact of STS on the workforce manifests in low morale, turnover, loss of productivity, job dissatisfaction and presenteeism. As organizations strive to become more trauma-informed, addressing the impact of traumatic stress on providers and first-responders becomes a critical component of best practice in a trauma-informed workplace. The implementation framework detailed in this paper serves to facilitate the development of organiz

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Gill, Charlotte, Denise Gottfredson, and Kirsten Hutzell. "Can school policing be trauma-informed? Lessons from Seattle." Policing: An International Journal of Police Strategies & Management 39, no. 3 (2016): 551–65. http://dx.doi.org/10.1108/pijpsm-02-2016-0020.

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Purpose The purpose of this paper is to describe Seattle’s School Emphasis Officer (SEO) program, a distinctive approach to school policing that aims to connect at-risk students with services and has potential to incorporate a trauma-informed approach. Design/methodology/approach Using qualitative data collected from a process evaluation of SEO, including interviews, observations, and analysis of activity logs and program documentation, the authors explore elements of the program that could be adapted for the development of a trauma-informed policing (TIP) model and highlight some potential pi

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Gregoriou, Andros, and Mark Rhodes. "The accuracy of spread decomposition models in capturing informed trades." Review of Behavioral Finance 9, no. 1 (2017): 2–13. http://dx.doi.org/10.1108/rbf-02-2017-0016.

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Purpose The purpose of this paper is to examine the empirical relationship between trades undertaken by informed agents (managers) and the proxies for informed trades computed by bid-ask spread decomposition models. Design/methodology/approach An econometric application of spread decomposition models to data from the London Stock Exchange, with an examination of whether the model predictions are co-integrated with actual outcomes. Findings The authors find overwhelming evidence of non-stationary behaviour between the actual and predicted informed trade prices. The findings suggest that there i

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Likens, Gene E. "Biogeochemistry, the watershed approach: some uses and limitations." Marine and Freshwater Research 52, no. 1 (2001): 5. http://dx.doi.org/10.1071/mf99188.

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The watershed (catchment) approach provides a powerful conceptual model for quantitatively evaluating the structure, function and change within a landscape or region. The values and limitations of this approach are considered in this paper, with particular reference to the Hubbard Brook watershed–ecosystem model. The need for informed long-term (sustained) research is stressed; a haphazard collection of data is rarely valuable. Team-building efforts will be needed increasingly in the future to enhance the success of multidisciplinary teams tackling large and complex environmental problems.

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Han, Yucen, Zirui Xu, An-Chang Shi, and Lei Zhang. "Pathways connecting two opposed bilayers with a fusion pore: a molecularly-informed phase field approach." Soft Matter 16, no. 2 (2020): 366–74. http://dx.doi.org/10.1039/c9sm01983a.

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A phase field model with two phase fields, representing the concentration and the head–tail separation of amphiphilic molecules, respectively, has been constructed using an extension of the Ohta–Kawasaki model (Macromolecules, 1986, 19, 2621–2632).

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Volkening, Alexandria, and Björn Sandstede. "Modelling stripe formation in zebrafish: an agent-based approach." Journal of The Royal Society Interface 12, no. 112 (2015): 20150812. http://dx.doi.org/10.1098/rsif.2015.0812.

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Zebrafish have distinctive black stripes and yellow interstripes that form owing to the interaction of different pigment cells. We present a two-population agent-based model for the development and regeneration of these stripes and interstripes informed by recent experimental results. Our model describes stripe pattern formation, laser ablation and mutations. We find that fish growth shortens the necessary scale for long-range interactions and that iridophores, a third type of pigment cell, help align stripes and interstripes.

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Ward-Lasher, Allison, Jill Messing, and Jillian Stein-Seroussi. "Implementation of Trauma-Informed Care in a Housing First Program for Survivors of Intimate Partner Violence: A Case Study." Advances in Social Work 18, no. 1 (2017): 202–16. http://dx.doi.org/10.18060/21313.

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The intersection of trauma with the need for safe, stable, sustainable, and long-term housing is important when working with survivors of intimate partner violence (IPV). IPV advocacy agencies are advised to use a trauma-informed approach to help practitioners understand the impact of IPV on individuals. Housing First, a model addressing homelessness that provides permanent housing without preconditions, has been found to increase housing stability for survivors of IPV. Thus, we used a case study approach to examine how practitioners and administrators implement trauma-informed care in a Housi

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van Breda, Adrian. "Developmental social case work: A process model." International Social Work 61, no. 1 (2015): 66–78. http://dx.doi.org/10.1177/0020872815603786.

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Social development has been adopted as South Africa’s social welfare approach and is increasingly being adopted in Africa and other parts of the developing world. The translation of developmental social welfare to social work has, however, been difficult for many social workers. A particularly challenging aspect of this translation concerns the practice of social case work within a social development approach, a topic that has received virtually no attention in the social development literature. This article constructs a process model for a form of social case work that is informed by social d

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Washburn, Jason J., Michelle Gebhardt, Denise M. Styer, K. R. Juzwin, and Lev Gottlieb. "Co-Occurring Disorders in the Treatment of Nonsuicidal Self-Injury: An Evidence-Informed Approach." Journal of Cognitive Psychotherapy 26, no. 4 (2012): 348–64. http://dx.doi.org/10.1891/0889-8391.26.4.348.

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Co-occurring disorders are common among patients who present for treatment with nonsuicidal self-injury (NSSI). Evidence-based approaches specifically designed for the treatment of NSSI are limited, although interest in this area of research is growing. An evidence-informed model for the treatment of NSSI and co-occurring disorders is presented here to stimulate interest in addressing co-occurring disorders in the treatment of NSSI. Case examples are presented to highlight the complexity of treating NSSI and co-occurring disorders and to illustrate a model of treatment at the acute level of ca

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Clewe, Oskar, Sebastian G. Wicha, Corné P. de Vogel, Jurriaan E. M. de Steenwinkel, and Ulrika S. H. Simonsson. "A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations." Journal of Antimicrobial Chemotherapy 73, no. 2 (2017): 437–47. http://dx.doi.org/10.1093/jac/dkx380.

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Coninck, Pierre De. "Citizen Involvement in Waste Management: An Application of The STOPER Model via an Informed Consensus Approach." Environmental Management 23, no. 1 (1999): 87–94. http://dx.doi.org/10.1007/s002679900169.

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Guterman, Jeffrey T., and James Rudes. "A Narrative Approach to Strategic Eclecticism." Journal of Mental Health Counseling 27, no. 1 (2005): 1–12. http://dx.doi.org/10.17744/mehc.27.1.tf591m8384t50njt.

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Strategic eclecticism is set forth as a basis from which to use divergent theories and techniques within narrative therapy, a process-oriented model informed by postmodernism. The theory and practice of narrative therapy are described. Principles and guidelines for employing a narrative approach to strategic eclecticism are explicated along with a case example. Directions for future research and theory building also are considered. It is suggested that a narrative approach to strategic eclecticism speaks to the need for convergence between the modernist and postmodernist schools.

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Lee, D., P. Ward, and P. Block. "A global approach to defining flood seasons." Hydrology and Earth System Sciences Discussions 12, no. 4 (2015): 4595–630. http://dx.doi.org/10.5194/hessd-12-4595-2015.

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Abstract. Globally, flood catastrophes lead all natural hazards in terms of impacts on society, causing billions of dollars of damages annually. While short-term flood warning systems are improving in number and sophistication, forecasting systems on the order of months to seasons are a rarity, yet may lead to further disaster preparedness. To lay the groundwork for prediction, dominant flood seasons must be adequately defined. A global approach is adopted here, using the PCR-GLOBWB model to define spatial and temporal characteristics of major flood seasons globally. The main flood season is i

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Mejdi, Abderrazak, Luca Alimonti, and Bryce Gardner. "Vibro-acoustic modeling of aircraft structures using Finite Element- informed Statistical Energy Analysis." INTER-NOISE and NOISE-CON Congress and Conference Proceedings 263, no. 3 (2021): 3479–87. http://dx.doi.org/10.3397/in-2021-2417.

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This paper addresses the problem of predicting the structure born and airborne sound transmission in aircraft using Statistical Energy Analysis (SEA). Often analytical formulations are used to approximate the SEA parameters. In the present prediction method, a finite element (FE)-informed SEA approach is employed. To compute the coupling coefficient, the structure is represented with a repetition of unit cell and an FE model of the unit cell is assigned to evaluate the direct field dynamic stiffness matrix of the SEA subsystems at the connections. An efficient strategy is employed to determine

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Qian, Zhong Sheng, and Huai Kou Miao. "Towards Testing Web Applications: A PFSM-Based Approach." Advanced Materials Research 204-210 (February 2011): 220–24. http://dx.doi.org/10.4028/www.scientific.net/amr.204-210.220.

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To ensure the quality of Web applications, Web testing is one of the effective methods. This paper proposes a Web usage model based on probable FSM (PFSM) which provides a way to derive the test cases for a Web application. The testing process is based on the idea that different parts of the Web application have different execution frequency. This testing method is a significant contribution to informed research.

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Cassese, Alberto, Michele Guindani, and Marina Vannucci. "A Bayesian Integrative Model for Genetical Genomics with Spatially Informed Variable Selection." Cancer Informatics 13s2 (January 2014): CIN.S13784. http://dx.doi.org/10.4137/cin.s13784.

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We consider a Bayesian hierarchical model for the integration of gene expression levels with comparative genomic hybridization (CGH) array measurements collected on the same subjects. The approach defines a measurement error model that relates the gene expression levels to latent copy number states. In turn, the latent states are related to the observed surrogate CGH measurements via a hidden Markov model. The model further incorporates variable selection with a spatial prior based on a probit link that exploits dependencies across adjacent DNA segments. Posterior inference is carried out via

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Washburn, Jacob D., Maria Katherine Mejia-Guerra, Guillaume Ramstein, et al. "Evolutionarily informed deep learning methods for predicting relative transcript abundance from DNA sequence." Proceedings of the National Academy of Sciences 116, no. 12 (2019): 5542–49. http://dx.doi.org/10.1073/pnas.1814551116.

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Deep learning methodologies have revolutionized prediction in many fields and show potential to do the same in molecular biology and genetics. However, applying these methods in their current forms ignores evolutionary dependencies within biological systems and can result in false positives and spurious conclusions. We developed two approaches that account for evolutionary relatedness in machine learning models: (i) gene-family–guided splitting and (ii) ortholog contrasts. The first approach accounts for evolution by constraining model training and testing sets to include different gene famili

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Johnston, Curtis K., Rena J. Eudy-Byrne, Ahmed Elmokadem, et al. "A Model-Informed Drug Development (MIDD) Approach for a Low Dose of Empagliflozin in Patients with Type 1 Diabetes." Pharmaceutics 13, no. 4 (2021): 485. http://dx.doi.org/10.3390/pharmaceutics13040485.

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In clinical trials, sodium-glucose co-transporter (SGLT) inhibitor use as adjunct to insulin therapy in type 1 diabetes (T1D) provides glucometabolic benefits while diabetic ketoacidosis risk is increased. The SGLT2 inhibitor empagliflozin was evaluated in two phase III trials: EASE-2 and EASE-3. A low, 2.5-mg dose was included in EASE-3 only. As the efficacy of higher empagliflozin doses (i.e., 10 and 25 mg) in T1D has been established in EASE-2 and EASE-3, a modeling and simulation approach was used to generate additional supportive evidence on efficacy for the 2.5-mg dose. We present the me

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Zunino, Andrea, Klaus Mosegaard, Katrine Lange, Yulia Melnikova, and Thomas Mejer Hansen. "Monte Carlo reservoir analysis combining seismic reflection data and informed priors." GEOPHYSICS 80, no. 1 (2015): R31—R41. http://dx.doi.org/10.1190/geo2014-0052.1.

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Determination of a petroleum reservoir structure and rock bulk properties relies extensively on inference from reflection seismology. However, classic deterministic methods to invert seismic data for reservoir properties suffer from some limitations, among which are the difficulty of handling complex, possibly nonlinear forward models, and the lack of robust uncertainty estimations. To overcome these limitations, we studied a methodology to invert seismic reflection data in the framework of the probabilistic approach to inverse problems, using a Markov chain Monte Carlo (McMC) algorithm with t

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Acciaio, Beatrice, Alexander M. G. Cox, and Martin Huesmann. "Model-independent pricing with insider information: a skorokhod embedding approach." Advances in Applied Probability 53, no. 1 (2021): 30–56. http://dx.doi.org/10.1017/apr.2020.50.

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AbstractIn this paper we consider the pricing and hedging of financial derivatives in a model-independent setting, for a trader with additional information, or beliefs, on the evolution of asset prices. In particular, we suppose that the trader wants to act in a way which is independent of any modelling assumptions, but that she observes market information in the form of the prices of vanilla call options on the asset. We also assume that both the payoff of the derivative, and the insider’s information or beliefs, which take the form of a set of impossible paths, are time-invariant. In this wa

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Angus, Lynne, Jennifer Lewin, Tali Boritz, et al. "Narrative Processes Coding System: A Dialectical Constructivist Approach to Assessing Client Change Processes in Emotion-Focused Therapy of Depression." Research in Psychotherapy: Psychopathology, Process and Outcome 15, no. 2 (2013): 54–61. http://dx.doi.org/10.4081/ripppo.2012.105.

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Drawing on a Dialectical Constructivist model of therapeutic change, this paper addresses the fundamental contributions of client narrative disclosure, emotional differentiation and reflexive meaning-making processes in emotion-focused treatments of depression. An overview of the multi-methodological steps undertaken to empirically investigate the contributions of client storytelling, emotional differentiation, and meaning-making processes, using the Narrative Processes Coding System (NPCS; Angus et al., 1999) are provided, followed by a summary of key research findings that informed the devel

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Corbett, John P., Patricio Colmegna, Jose Garcia-Tirado, and Marc D. Breton. "Anticipating Meals with Behavioral Profiles in an Artificial Pancreas System - An Informed Multistage Model Predictive Control Approach." IFAC-PapersOnLine 53, no. 2 (2020): 16305–10. http://dx.doi.org/10.1016/j.ifacol.2020.12.652.

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