Relevant bibliographies by topics / Modèle de cornée ex-vivo

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  2. Dissertations / Theses
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Academic literature on the topic 'Modèle de cornée ex-vivo'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "Modèle de cornée ex-vivo"

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La Croix, C., E. Mornet, C. Clodic, T. Montier, G. Valette, and R. Marianowski. "Transfert de gène sur un modèle d’organe de Corti ex vivo." Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale 129, no. 4 (2012): A19—A20. http://dx.doi.org/10.1016/j.aforl.2012.07.048.

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Norol, F., M. Drouet, N. Debili, W. Vainchenker, and F. Herodin. "Expansion ex-vivo des cellules hématopoïétiques : étude dans le modèle primate." Hematology and Cell Therapy 41, no. 2 (1999): 75–77. http://dx.doi.org/10.1007/s00282-999-0075-x.

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Drugeon, H. B., and R. Garraffo. "Pharmacocinétique et pouvoir bactéricide du céfuroxime axétil : modèle in vitro/ex vivo." Médecine et Maladies Infectieuses 21 (September 1991): 56–60. http://dx.doi.org/10.1016/s0399-077x(05)80475-5.

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Boisnic, S., L. Ben Slama, M. C. Branchet-Gumila, M. Watts, and G. d’Arros. "Effet anti-inflammatoire de l’enoxolone dans un modèle ex-vivo de muqueuse gingivale humaine." Revue de Stomatologie et de Chirurgie Maxillo-faciale 111, no. 2 (2010): 69–73. http://dx.doi.org/10.1016/j.stomax.2010.02.005.

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Bergougnoux, A., L. Knabe, A. Fort, et al. "Effets du SAHA (iHDAC) sur un modèle ex vivo d’épithélium nasal de patients atteints de mucoviscidose." Revue des Maladies Respiratoires 31, no. 7 (2014): 669. http://dx.doi.org/10.1016/j.rmr.2014.04.058.

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Trinh, L., F. Brignole-Baudouin, A. Labbe, M. Raphael, J. L. Bourges, and C. Baudouin. "321 L’endothélium cornéen dans un modèle d’uvéite induite par endotoxine : corrélation entre microscopie confocale in vivo et immunohistochimie." Journal Français d'Ophtalmologie 31 (April 2008): 109. http://dx.doi.org/10.1016/s0181-5512(08)70918-5.

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Brunet, K., F. Arrivé, J. Martellosio, et al. "Les corticoïdes altèrent la réponse des macrophages alvéolaires contre Lichtheimia corymbifera dans un modèle murin ex vivo." Médecine et Maladies Infectieuses 50, no. 6 (2020): S119. http://dx.doi.org/10.1016/j.medmal.2020.06.248.

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Lebonvallet, N., D. Sevrain, Y. Legrand, C. Jeanmaire, G. Pauly, and L. Misery. "Étude de la ré-innervation cutanée humaine dans un modèle ex vivo en utilisant la microscopie biphotonique." Annales de Dermatologie et de Vénéréologie 138, no. 12 (2011): A226. http://dx.doi.org/10.1016/j.annder.2011.10.245.

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Sharif, M. A., U. Bayraktutan, N. Arya, et al. "Le tabagisme perturbe la fonction endothéliale de la veine saphène humaine dans un modèle expérimental ex-vivo." Annales de Chirurgie Vasculaire 23, no. 1 (2009): 126–31. http://dx.doi.org/10.1016/j.acvfr.2009.04.004.

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Dupin, C., E. Lhuillier, S. Létuvé, et al. "Altération des propriétés immunosuppressives de l’épithélium bronchique chez les greffés pulmonaires : modèle ex vivo de réponse T-allogénique." Revue des Maladies Respiratoires 32, no. 3 (2015): 337. http://dx.doi.org/10.1016/j.rmr.2015.02.080.

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Dissertations / Theses on the topic "Modèle de cornée ex-vivo"

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Rovere, Maria. "Reconstruction cornéenne : traitement des déficiences en cellules souches limbiques totales et bilatérales associées ou non à une atteinte du stroma." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1263.

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Certaines brûlures oculaires graves ou d'autres pathologies oculaires rares peuvent être associées à une perte totale de cellules souches épithéliales de la cornée (DCSL), ce qui conduit à une opacification de la cornée par invasion de la conjonctive. Lorsque la DCSL est totale et bilatérale, le limbe controlatéral n'est pas disponible pour la greffe de limbe autologue ou la culture de cellules souches autologues limbiques et la transplantation allogénique de la cornée est impossible car toujours rejetée en raison de la néovascularisation. Une thérapie innovante testée avec succès au sein de n
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Raude, Emma. "Développement, validation et caractérisation d’un modèle ex vivo de peau humaine perfusé : FlowSkin." Thesis, Toulouse, INSA, 2020. http://www.theses.fr/2020ISAT0015.

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Les modèles organotypiques tels que les explants de peau humaine sont les modèles les plus complexes et parmi les plus représentatifs de la peau in vivo existants à ce jour pour tester l’efficacité ou l’innocuité de molécules d’intérêts thérapeutiques au stade des études pré-cliniques. Cependant, l’absence de circulation sanguine et lymphatique dans ces modèles reste une limite importante dans l’homéostasie du tissu, notamment pour prédire les réponses de la peau à un traitement. De plus, les échanges en nutriments et en oxygène n’étant possibles que par diffusion, la durée de vie de ces modèl
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Gil, Marion. "Rétrodiffusion lumineuse pour le diagnostic précoce et le suivi de pathologies du stroma cornéen : étude expérimentale ex vivo et modélisation." Thesis, Aix-Marseille, 2019. http://theses.univ-amu.fr.lama.univ-amu.fr/190521_GIL_362fb71obz103p970n_TH.pdf.

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Une des fonctions principales de la cornée est de laisser passer la lumière à l’intérieur de l’œil. Cette propriété est notamment liée à une organisation très particulière de son volume, à l’échelle nanométrique. Cette dernière permet de minimiser la diffusion lumineuse qui va au contraire augmenter lorsque certaines pathologies se développent. La diffusion, étant directement liée à la modification structurelle et à différentes échelles du tissu, l’objectif de ce travail de thèse est de montrer en quoi l’étude de la diffusion angulaire apporte une caractérisation riche sur l’état de la cornée,
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Capito, Carmen. "Développement du pancréas humain embryonnaire ex vivo / in vivo : La greffe musculaire : un nouveau modèle d'étude longitudinale et dynamique." Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00862466.

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Au-delà de l'intérêt cognitif de la démarche, la compréhension des mécanismes qui régissent le développement pancréatique humain reste la clé pour décrypter les acteurs physiopathologiques des maladies du pancréas et pour développer des approches thérapeutiques innovantes. En outre, alors que la cellule bêta de rongeurs et la cellule bêta humaine partagent un grand nombre de similitudes, certaines données indiquent également des différences marquées entre les espèces. L'absence de systèmes expérimentaux robustes , à partir de matériel humain, n'a pas permis un examen détaillé du développement
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Bessou, Sandrine. "Épiderme reconstitué ex-vivo avec des mélanocytes : validation d'un nouveau modèle d'étude de la pigmentation." Bordeaux 2, 1997. http://www.theses.fr/1997BOR28460.

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Turchi, Laurent. "Mise au point et validation d'un modèle d'étude in vivo et ex vivo des aspects moléculaires de la cicatrisation cutanée." Nice, 2002. http://www.theses.fr/2002NICE5732.

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Sébert, Morgane. "Les effets de la thrombine sur l'épithélium colique humain, grâce aux organoïdes (modèle ex vivo, 3D)." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30006/document.

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La thrombine, une protéase à sérine connue pour être l'acteur clé de la cascade de coagulation, a été décrite pour réguler les processus apoptotiques au niveau du côlon via l'activation de récepteurs activés par des protéases ou PARs (Protease-Activated Receptors). Cependant, les effets de la thrombine sur la cellule épithéliale colique n'ont été étudiés qu'en utilisant des lignées cellulaires. Les conséquences d'une exposition à différentes doses de thrombine sur un épithélium complexe, composés de différents types cellulaires plus ou moins différenciés sont inconnues à ce jour. Un nouveau mo
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Fyffe, James G. "Corneal injury to ex-vivo eyes exposed to a 3.8 micron laser /." Download the thesis in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Fyffe2005.pdf.

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Jardet, Claire. "Développement d’un modèle humain de mélanome ex vivo basé sur l’implantation de sphéroïdes dans des explants de peau." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30282.

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Le mélanome métastatique est le cancer de la peau le plus agressif. Bien que son taux d’incidence soit inférieur à 1%, plus de 75% des décès associés à un cancer de la peau lui sont attribués. Au cours des dernières années, de nouvelles stratégies thérapeutiques ont permis d’améliorer la survie des patients. Cependant, des mécanismes de résistance à ces traitements se développent dans la majorité des cas, conduisant à une phase de rechute, et une survie à 5 ans inférieure à 20%. Des modèles d’étude expérimentaux sont nécessaires afin de comprendre les mécanismes impliqués dans l’apparition de
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Escoffier, Patricia. "Application de la protéomique clinique au diagnostic biologique de la toxoplasmose oculaire." Paris 6, 2010. http://www.theses.fr/2010PA066032.

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La toxoplasmose oculaire (TO) représente la première source d’inflammation du segment postérieur de l’œil. Le diagnostic est principalement ophtalmologique, cependant le recours au diagnostic biologique est indispensable en cas de formes cliniques atypiques et vise à mettre en évidence dans l’humeur aqueuse (HA) une synthèse locale d’anticorps anti-toxoplasmiques (Coefficient de Desmont, Western blot) ou le parasite (PCR). Le manque de sensibilité de ces méthodes nécessite la réalisation des 3 techniques et donc un volume important d’HA et ne permet d’atteindre qu’une sensibilité égale à 80 %.
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Books on the topic "Modèle de cornée ex-vivo"

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Burns, Tom, and Mike Firn. Model variance and model fidelity: The lessons from ACT. Edited by Tom Burns and Mike Firn. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198754237.003.0004.

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This chapter takes the assertive community treatment (ACT) model of community outreach as a starting point and examines what can and what cannot be varied and still achieve good results. ACT has a special place in community outreach as it was the first model of care confirmed by research, and controversy has raged about the need, or otherwise, for ‘model fidelity’. The chapter identifies the core ingredients—small caseloads, in vivo psychosocial treatments, mainstreaming, flexibility, 24/7 availability—and examines the evidence for and against them. It pays particular attention to the roles of
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Book chapters on the topic "Modèle de cornée ex-vivo"

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Reid, Erin K., Leslie K. Taylor, Kelly N. Banneyer, et al. "Core CBT Components." In Applied Cognitive Behavioral Therapy in Schools. Oxford University Press, 2021. http://dx.doi.org/10.1093/med-psych/9780197581384.003.0007.

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Chapter 7 presents another core cognitive behavioral therapy (CBT) skill: CBT with exposure and response prevention, a first-line treatment for obsessive-compulsive and anxiety-related disorders. After briefly highlighting the efficacy research for children and adolescents, this chapter describes the technique’s theoretical framework, explains it in detail, addresses common misconceptions, and guides practitioners in developing customized fear hierarchies for students. Next, the chapter carefully describes the technique’s trauma applications, including trauma narratives and in vivo exposures. Differences between treatments for anxiety and trauma are noted, as well as complexities that arise from complex trauma. The chapter concludes with a discussion of trauma-focused CBT in schools and stepped-care models and provides a detailed case study.
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Conference papers on the topic "Modèle de cornée ex-vivo"

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Khan, Altaf, Zoujun Dai, and Thomas J. Royston. "Measuring and Modeling Elastography of Human Cornea Using Scanning Laser Doppler Vibrometry." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14566.

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Our interest is in noninvasively mapping the viscoelastic properties of the human cornea with the aid of a Scanning Laser Doppler Vibrometer (SLDV). Mechanical properties of the cornea can be used to predict early onset of diseases, such as glaucoma and keratoconus. By applying mechanical vibration near the cornea and measuring the dynamic wave propagation across the cornea, an elastographic map can be reconstructed. To effectively reconstruct the data, an appropriate analytical solution is needed to interpret the measured motion; in the present article, we review initial measurements and mode
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Nieuwstadt, Harm A., Ali C. Akyildiz, Lambert Speelman, et al. "3D Stress Computations in Atherosclerotic Arteries: The Influence of Axial Image Resolution." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80514.

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Sudden rupture of vulnerable atherosclerotic plaques is a major contributing cause of acute myocardial infarctions and ischemic strokes [1]. A vulnerable plaque is defined as a plaque with a large necrotic core and a thin fibrous cap. In order to characterize, and further comprehend, plaque vulnerability from a mechanical point of view, the rupture process can be seen as a mechanical process which occurs when the tensile stress in the fibrous cap exceeds its material strength. Biomechanical stress modeling of plaques using the Finite Element Method (FEM) has been used as a tool to provide insi
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Moriyama, Kiyofumi, Hyun Sun Park, Mooneon Lee, and Jin Ho Park. "Parametric Model for Ex-Vessel Melt Jet Breakup and Debris Bed Cooling." In 2018 26th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icone26-81465.

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The process of the ex-vessel molten core cooling in a pre-flooded reactor cavity during a severe accident of a light water reactor includes complicated phenomena such as melt jet breakup, debris bed formation and cooling and the molten core-concrete interaction. The melt coolability and its impact on the containment consequences are dependent on the interactions among those phenomena. A simplified parametric model, COOLAP-II, covering the melt jet breakup, debris bed formation and cooling was developed for the synthetic assessment of the ex-vessel melt coolability. The model was validated on t
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Robb, Kevin R., and Michael L. Corradini. "Towards Understanding Melt Eruption Phenomena During Molten Corium Concrete Interactions." In 18th International Conference on Nuclear Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/icone18-30116.

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A defense-in-depth feature for advanced light water reactors to cope with beyond design basis accidents is the ability to cool and stabilize ex-vessel core melt debris. Several international experimental programs have investigated core-concrete interactions and debris cooling of ex-vessel core melts. These experimental programs have identified various phenomena which affect melt coolability and may enhance it. One such phenomenon, melt eruptions, occurs when gas from the underlying decomposing concrete entrains melt up through and onto a solidified crust, which separates the molten melt from t
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Zhang, Juanhua, Jiming Lin, and Shishun Zhang. "Analysis on Ex-Vessel Steam Explosion in CPR1000+ Unit." In 18th International Conference on Nuclear Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/icone18-30340.

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Reactor Pit Flooding System (RPF) is adopted under the severe accidents situation in CPR1000+ units. It can move the heat generated from the reactor core via external reactor vessel cooling (ERVC) to keep the integrity of RPV and achieve the in-vessel corium retention (IVR). But if IVR function of RPF is failed, there is Ex-Vessel Steam Explosion (EX-SE) risk. The Ex-Vessel Steam Explosion is analyzed by MC3D software which is for fuel and cooling interaction (FCI). The physical model of CPR1000+ for Steam Explosion is built firstly and then the phenomenon of Ex-Vessel Steam Explosion under ty
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Chen, Bin. "Core-Catcher Coolability Analysis With Coupled THEMA and RELAP Codes." In 16th International Conference on Nuclear Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/icone16-48624.

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Core-catcher concept is widely used as a mitigation measure for containment protection under severe accident condition. Preliminary design of core-catcher is combined with ex-vessel corium behavior and corium cooling. The loose coupling of THEMA and RELAP codes provides a convenient method to evaluation the coolability of core catcher with a realistic ex-vessel corium characteristic by couple the corium and concrete basemat parameters like spreading area heat flux and etc. calculated by THEMA code and thermal-hydraulic transient behavior of coolant which flows through the basemat and is calcul
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Dabin, Zhang, Zhiwei Zhou, Heng Xie, and Tang Yang. "Preliminary Severe Accident Analysis of Fusion-Fission Hybrid Reactor Using the MELCOR Code." In 2014 22nd International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icone22-30644.

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The fusion-fission hybrid conceptual reactor is a proposed means of generating power, which adopts a water cooled fission blanket based on ITER. Due to the water cooled fission blanket, safety performance of the hybrid reactor should be considered, including decay heat remove, core uncovered, core meltdown, core degradation, radioactivity releases, etc., similar with the PWRs. The main goal of this work is to develop the fission blanket model by using MELCOR code, and to evaluate the safety performance under severe accidents preliminarily. Based on MELCOR 1.8.5, some modification is made for t
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Frolov, Kyrill N., Michel Duclot, and Christophe Journeau. "Interface Stability Criteria for Ex-Vessel Corium Solidification." In 12th International Conference on Nuclear Engineering. ASMEDC, 2004. http://dx.doi.org/10.1115/icone12-49529.

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In case of a severe accident at a nuclear power plant (NPP) involving the reactor core melt-down and the subsequent reactor pressure vessel (RPV) melt-through, confident solidification of ex-vessel corium is considered to be the imperative condition of safe retention of corium within the plant containment in the long term. The rate-determining process for solidification of ex-vessel coriums in the long-term is the chemical diffusion in the liquid phase at the solid-liquid interface. The process of chemical diffusion in the diffusive boundary layer can evolve and take on different rates, depend
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Kwon, Gunup, Michael R. Davieau, Phuong Hoang, John B. McLean, and Robert W. Hooks. "Evaluation of Reactor Cavity Structure for Ex-Vessel Steam Explosion Loading." In ASME 2016 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/pvp2016-63092.

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This paper documents the analytical evaluation of a reactor cavity structure subjected to ex-vessel steam explosion loading. The ex-vessel steam explosion may occur during a severe accident scenario after beyond-design-basis earthquake event when the molten core of the failed vessel begins to drop into a flooded reactor cavity area. This causes an impulse load on the reactor cavity that can impose greater demand on the structural components. The structural integrity and leak-tightness of the reactor cavity structure were evaluated using a detailed finite element analysis model. For selected cr
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Boyce, B. L., T. D. Nguyen, and R. E. Jones. "Full-Field Viscoelastic Inflation Response of Bovine Cornea." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192974.

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Most previous experimental studies and mechanical cornea models have ignored time-dependence of the cornea’s modulus, with only a few notable exceptions [1–3]. The purpose of the present work was to evaluate the time-dependent properties of cornea tissue independent of scleral contributions in a condition that is as physiologically-relevant as possible without resorting to costly and difficult in vivo characterization. A non-contact 3-dimensional displacement mapping tool was employed to image the entire deformation field across the entire cornea in real-time during pressurization. Unlike prio
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