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Journal articles on the topic 'Modèle intestinal in vitro'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Uriot, O., C. Deschamps, M. Brun, et al. "Développement et validation d’un modèle colique in vitro de dysbiose du microbiote intestinal humain associé à l’obésité." Nutrition Clinique et Métabolisme 37, no. 2 (2023): e20. http://dx.doi.org/10.1016/j.nupar.2023.03.032.

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2

Krause, J.L., A. Pierzchalski, H.D. Chang, A.C. Zenclussen, M. Bauer, and G. Herberth. "Bisphenols, but not phthalate esters, modulate gene expression in activated human MAIT cells in vitro." Toxicology Reports 10 (July 6, 2023): 348–56. https://doi.org/10.1016/j.toxrep.2023.02.017.

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One route of human exposure to environmental chemicals is oral uptake. This is primarily true for chemicals that may leach from food packaging materials, such as bisphenols and phthalate esters. Upon ingestion, these compounds are transported along the intestinal tract, from where they can be taken up into the blood stream or distributed to mucosal sites. At mucosal sites, mucosal immune cells and in the blood stream peripheral immune cells may be exposed to these chemicals potentially modulating immune cell functions. In the present study, we investigated the impact of three common bisphenols

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3

Amamou, A., L. Yaker, C. Bôle-Feysot, G. Savoye, and R. Marion-Letellier. "Étude de l’interaction entre des dérivés du tryptophane et le récepteur aryl hydrocarbone dans un modèle in vitro de fibrose intestinale." Nutrition Clinique et Métabolisme 33, no. 1 (2019): 100. http://dx.doi.org/10.1016/j.nupar.2019.01.412.

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4

Vergères, Guy, Biljana Bogicevic, Caroline Buri, et al. "The NutriChip project – translating technology into nutritional knowledge." British Journal of Nutrition 108, no. 5 (2012): 762–68. http://dx.doi.org/10.1017/s0007114512002693.

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Advances in food transformation have dramatically increased the diversity of products on the market and, consequently, exposed consumers to a complex spectrum of bioactive nutrients whose potential risks and benefits have mostly not been confidently demonstrated. Therefore, tools are needed to efficiently screen products for selected physiological properties before they enter the market. NutriChip is an interdisciplinary modular project funded by the Swiss programme Nano-Tera, which groups scientists from several areas of research with the aim of developing analytical strategies that will enab

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5

Jackson, Tim R., Miniver Oliver, Daniel Appledorn, Tim Dale, and Kalpana Barnes. "Abstract 3084: Label-free, real-time live cell assays for 3D organoids embedded in Matrigel®." Cancer Research 82, no. 12_Supplement (2022): 3084. http://dx.doi.org/10.1158/1538-7445.am2022-3084.

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Abstract Organoid technologies are increasingly being used as in-vitro models of human development and disease as they exhibit structural, morphogenetic, and functional properties that recapitulate in vivo pathophysiology. To successfully use these models across a variety of research disciplines and applications, approaches that reduce variability and technology pipelines to image & quantify these complex cell models are required. Here, we demonstrate simple, robust workflows for monitoring and automatically quantifying features, such as morphology, growth and death of organoids using real

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6

Tagawa, Kozo, Akiko Kiriyama, San Yuet Lin, and Sota Fukunaga. "Development of dissolution evaluation system for drug absorption (V): Additional intestinal absorption module of in vitro 3D gastric emptying mmodel for orally disintegrating tablet." Drug Metabolism and Pharmacokinetics 61 (June 2025): 101140. https://doi.org/10.1016/j.dmpk.2025.101140.

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7

Losa, Marco, Michael Field, Lauren Collen, et al. "BIOACTIVE INTERLEUKIN-1 DETECTED IN IBD PATIENT INTESTINAL BIOPSIES IS A HALLMARK OF ULCERS AND CORRELATES WITH TRANSCRIPTOMIC ASSESSMENTS, INCLUDING AN ULCER-ASSOCIATED GENE MODULE." Inflammatory Bowel Diseases 30, Supplement_1 (2024): S00. http://dx.doi.org/10.1093/ibd/izae020.117.

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Abstract BACKGROUND Interleukin (IL)-1 and its post-translationally modified and released forms, IL-1α and IL-1β, have been identified as key molecules to maintain mucosal homeostasis and to drive inflammatory bowel disease (IBD). Deep cellular phenotypic, transcriptional, and in vitro data highlight the importance of IL-1-associated cytokine networks and IL-1 producing cells in severe and anti-TNF non-responsive IBD. Nevertheless, little is known about the presence of bioactive IL-1 proteins within the cell-free gastrointestinal (GI) mucosal environment and associated function in severe IBD a

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8

Rashid, Md Harun Or, and Feng Lin. "Magnetically Driven Biopsy Capsule Robot with Spring Mechanism." Micromachines 15, no. 2 (2024): 287. http://dx.doi.org/10.3390/mi15020287.

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In recent years, capsule endoscopes (CEs) have appeared as an advanced technology for the diagnosis of gastrointestinal diseases. However, only capturing the images limits the advanced diagnostic procedures and so on in CE’s applications. Herein, considering other extended functions like tissue sampling, a novel wireless biopsy CE has been presented employing active locomotion. Two permanent magnets (PMs) have been placed into the robots, which control the actuation of the capsule robot (CR) and biopsy mechanism by employing an external electromagnetic actuation (EMA) system. A spring has been

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9

Dupont, C., M. E. Bougnoux, J. Matéo, P. Saulnier, D. Payen, and M. H. Nicolas-Chanoine. "Diagnostic des candidoses profondes par PCR modèle in vitro et modèle animal." La Revue de Médecine Interne 17 (January 1996): 356s. http://dx.doi.org/10.1016/s0248-8663(97)80878-8.

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10

Dupont, C., M. E. Bougnoux, J. Mateo, P. Saulnier, D. Payen, and M. H. Nicolas-Chanoine. "Diagnostic des candidoses profondes par PCR. Modèle in vitro et modèle animal." Médecine et Maladies Infectieuses 27 (November 1997): 1005. http://dx.doi.org/10.1016/s0399-077x(97)80272-7.

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11

Durix, A., L. Alves de Oliveira, S. Komizarczuck-Bony, M. Carcelen, and C. Jean-Blain. "Caractéristiques fermentaires d'un modèle d'acidose in vitro (RUSITEC)." Annales de Zootechnie 43, Suppl. 1 (1994): 26s. http://dx.doi.org/10.1051/animres:19940530.

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12

Breton, J., P. Tirelle, S. Hasanat, et al. "Altérations du microbiote intestinal dans un modèle murin d’Anorexie mentale." Nutrition Clinique et Métabolisme 34, no. 1 (2020): 37–38. http://dx.doi.org/10.1016/j.nupar.2020.02.238.

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13

Le Pape, P. "Persistance fongique et granulome : nouveau modèle d’étude in vitro." Journal de Mycologie Médicale 23, no. 1 (2013): 71–72. http://dx.doi.org/10.1016/j.mycmed.2012.12.011.

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14

Bonnin, Alain, and Frédéric Dalle. "Importance des micromycètes dans le microbiote intestinal : le modèle Candida albicans." Bulletin de l'Académie Nationale de Médecine 202, no. 7 (2018): 1401–12. http://dx.doi.org/10.1016/s0001-4079(19)30206-7.

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15

Chopra, Dharam P., Alan A. Dombkowski, Paul M. Stemmer, and Graham C. Parker. "Intestinal Epithelial Cells In Vitro." Stem Cells and Development 19, no. 1 (2010): 131–42. http://dx.doi.org/10.1089/scd.2009.0109.

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16

Barranco, Caroline. "Intestinal tissue generated in vitro." Nature Reviews Gastroenterology & Hepatology 8, no. 2 (2011): 63. http://dx.doi.org/10.1038/nrgastro.2010.226.

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17

Längst, Emmanuel, David Crettaz, Manon Bardyn, Jean-Daniel Tissot, and Michel Prudent. "Modèle de transfusion in vitro pour étudier les globules rouges." Transfusion Clinique et Biologique 28, no. 4 (2021): S105. http://dx.doi.org/10.1016/j.tracli.2021.08.308.

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18

Riethorst, Danny, Joachim Brouwers, Jens Motmans, and Patrick Augustijns. "Human intestinal fluid factors affecting intestinal drug permeation in vitro." European Journal of Pharmaceutical Sciences 121 (August 2018): 338–46. http://dx.doi.org/10.1016/j.ejps.2018.06.007.

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19

Baldolli, A., F. Vincent, B. Bienvenu, W. Figgett, and F. Mackay. "Rôle du microbiote intestinal dans un modèle murin de lupus transgénique pour BAFF." La Revue de Médecine Interne 36 (December 2015): A82—A83. http://dx.doi.org/10.1016/j.revmed.2015.10.312.

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20

Fair, Kathryn L., Jennifer Colquhoun, and Nicholas R. F. Hannan. "Intestinal organoids for modelling intestinal development and disease." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1750 (2018): 20170217. http://dx.doi.org/10.1098/rstb.2017.0217.

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Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited insight into the mechanisms that initiate and propagate these diseases. Human-specific models of intestinal development and disease are desperately needed that can recapitulate structure and function of the gut in vitro . Advances in pluripotent stem cells and primary tissue culture techniques have made it possible to culture intestinal epithelial cells in three dimensions that self-assemble to form ‘intestinal organoids'. These organoi

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21

Rahmani, Sara, Natalia M. Breyner, Hsuan-Ming Su, Elena F. Verdu, and Tohid F. Didar. "Intestinal organoids: A new paradigm for engineering intestinal epithelium in vitro." Biomaterials 194 (February 2019): 195–214. http://dx.doi.org/10.1016/j.biomaterials.2018.12.006.

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22

Creff, Justine, Laurent Malaquin, and Arnaud Besson. "In vitro models of intestinal epithelium: Toward bioengineered systems." Journal of Tissue Engineering 12 (January 2021): 204173142098520. http://dx.doi.org/10.1177/2041731420985202.

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The intestinal epithelium, the fastest renewing tissue in human, is a complex tissue hosting multiple cell types with a dynamic and multiparametric microenvironment, making it particularly challenging to recreate in vitro. Convergence of recent advances in cellular biology and microfabrication technologies have led to the development of various bioengineered systems to model and study the intestinal epithelium. Theses microfabricated in vitro models may constitute an alternative to current approaches for studying the fundamental mechanisms governing intestinal homeostasis and pathologies, as w

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23

Hosni, H., A. Salama, A. Abudunia, Y. Cherrah, A. Ibrahimi, and K. Alaoui. "Toxicité aiguë, cytotoxicité et effet antiradicalaire de l’extrait méthanolique des feuilles de l’asphodèle, Asphodelus microcarpus." Phytothérapie 18, no. 5 (2019): 284–90. http://dx.doi.org/10.3166/phyto-2019-0136.

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Asphodelus microcarpus(A.m.) est une plante largement utilisée en médecine traditionnelle marocaine pour ses propriétés médicinales qui restent variées et générales. Une extraction des principes actifs contenus dans les feuilles d’A.m. a été réalisée par macération à froid au méthanol. L’extrait obtenu a fait l’objet d’une étude in vitro de cytotoxicité qui a révélé un effet cytotoxique sur un modèle de cellules myéloïdes d’origine humaine (IC50 = 7,81 μg/ml). Par ailleurs, l’évaluation de l’extrait quant à son activité antioxydante par la méthode du réactif DPPH s’est révélée positive (IC50 =

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24

Alno, Nora, Franck Jegoux, Pascal Pellen-Mussi, Sylvie Tricot-Doleux, Guy Cathelineau, and Gilbert De Mello. "Mise au point d’un modèle tridimensionnel pour l’évaluation des biosubstituts osseuxin vitro." Médecine Buccale Chirurgie Buccale 16, no. 4 (2010): 199–208. http://dx.doi.org/10.1051/mbcb/2010039.

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25

Alno, Nora, Franck Jegoux, Pascal Pellen-Mussi, Sylvie Tricot-Doleux, Guy Cathelineau, and Gilbert De Mello. "Mise au point d’un modèle tridimensionnel pour l’évaluation des biosubstituts osseuxin vitro." Médecine Buccale Chirurgie Buccale 17, no. 1 (2010): 71–81. http://dx.doi.org/10.1051/mbcb/2010041.

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26

Drugeon, H. B., and R. Garraffo. "Pharmacocinétique et pouvoir bactéricide du céfuroxime axétil : modèle in vitro/ex vivo." Médecine et Maladies Infectieuses 21 (September 1991): 56–60. http://dx.doi.org/10.1016/s0399-077x(05)80475-5.

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27

Gailloud, P., J. R. Pray, M. Muster, M. Piotin, J. H. D. Fasel, and D. A. Rüfenacht. "Un modèle anatomiquein vitro des artères cérébrales humaines avec anévrysmes artériels sacciformes." Surgical and Radiologic Anatomy 19, S2 (1997): 28–29. http://dx.doi.org/10.1007/bf01642141.

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28

Faway, E., L. Cambier, C. Lambert de Rouvroit, B. Mignon, and Y. Poumay. "Développement et analyse d’un modèle in vitro d’infection épidermique par dermatophytes anthropophiles." Annales de Dermatologie et de Vénéréologie 142, no. 6-7 (2015): S285. http://dx.doi.org/10.1016/j.annder.2015.04.028.

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29

Panthier, F., P. Lapouge, S. Doizi, L. Dragos, L. Berthe, and O. Traxer. "Analyse in vitro de l’efficacité de la lithotritie laser : quel modèle utiliser ?" Progrès en Urologie 30, no. 13 (2020): 709–10. http://dx.doi.org/10.1016/j.purol.2020.07.031.

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30

Forsyth, Christopher B., Robin M. Voigt, Maliha Shaikh, et al. "Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability." American Journal of Physiology-Gastrointestinal and Liver Physiology 305, no. 2 (2013): G185—G195. http://dx.doi.org/10.1152/ajpgi.00354.2012.

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We have shown that alcohol increases Caco-2 intestinal epithelial cell monolayer permeability in vitro by inducing the expression of redox-sensitive circadian clock proteins CLOCK and PER2 and that these proteins are necessary for alcohol-induced hyperpermeability. We hypothesized that alcohol metabolism by intestinal Cytochrome P450 isoform 2E1 (CYP2E1) could alter circadian gene expression ( Clock and Per2), resulting in alcohol-induced hyperpermeability. In vitro Caco-2 intestinal epithelial cells were exposed to alcohol, and CYP2E1 protein, activity, and mRNA were measured. CYP2E1 expressi

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31

Xiang, Yunqing, Hui Wen, Yue Yu, Mingqiang Li, Xiongfei Fu, and Shuqiang Huang. "Gut-on-chip: Recreating human intestine in vitro." Journal of Tissue Engineering 11 (January 2020): 204173142096531. http://dx.doi.org/10.1177/2041731420965318.

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The human gut is important for food digestion and absorption, as well as a venue for a large number of microorganisms that coexist with the host. Although numerous in vitro models have been proposed to study intestinal pathology or interactions between intestinal microbes and host, they are far from recapitulating the real intestinal microenvironment in vivo. To assist researchers in further understanding gut physiology, the intestinal microbiome, and disease processes, a novel technology primarily based on microfluidics and cell biology, called “gut-on-chip,” was developed to simulate the str

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32

Hamilton, I., I. Cobden, and A. T. Axon. "In vitro determination of small intestinal permeability." Gut 26, no. 3 (1985): 322–24. http://dx.doi.org/10.1136/gut.26.3.322.

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33

Mayer, Robert M., Carleton R. Treadwell, Linda L. Gallo, and George V. Vahouny. "Intestinal mucins and cholesterol uptake in vitro." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 833, no. 1 (1985): 34–43. http://dx.doi.org/10.1016/0005-2760(85)90250-4.

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34

Lamberti, Gaetano, Sara Cascone, Margherita Iannaccone, and Giuseppe Titomanlio. "In vitro simulation of drug intestinal absorption." International Journal of Pharmaceutics 439, no. 1-2 (2012): 165–68. http://dx.doi.org/10.1016/j.ijpharm.2012.10.012.

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35

Krueger, Dagmar, Klaus Michel, Florian Zeller, et al. "Neural influences on human intestinal epitheliumin vitro." Journal of Physiology 594, no. 2 (2015): 357–72. http://dx.doi.org/10.1113/jp271493.

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36

Stelzner, Matthias, Michael Helmrath, James C. Y. Dunn, et al. "A nomenclature for intestinal in vitro cultures." American Journal of Physiology-Gastrointestinal and Liver Physiology 302, no. 12 (2012): G1359—G1363. http://dx.doi.org/10.1152/ajpgi.00493.2011.

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Many advances have been reported in the long-term culture of intestinal mucosal cells in recent years. A significant number of publications have described new culture media, cell formations, and growth patterns. Furthermore, it is now possible to study, e.g., the capabilities of isolated stem cells or the interactions between stem cells and mesenchyme. However, at the moment there is significant variation in the way these structures are described and named. A standardized nomenclature would benefit the ability to communicate and compare findings from different laboratories using the different

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37

Bertero, Alessia, Paola Fossati, Doriana Eurosia Angela Tedesco, and Francesca Caloni. "Beauvericin and Enniatins: In Vitro Intestinal Effects." Toxins 12, no. 11 (2020): 686. http://dx.doi.org/10.3390/toxins12110686.

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Food and feed contamination by emerging mycotoxins beauvericin and enniatins is a worldwide health problem and a matter of great concern nowadays, and data on their toxicological behavior are still scarce. As ingestion is the major route of exposure to mycotoxins in food and feed, the gastrointestinal tract represents the first barrier encountered by these natural contaminants and the first structure that could be affected by their potential detrimental effects. In order to perform a complete and reliable toxicological evaluation, this fundamental site cannot be disregarded. Several in vitro i

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38

Alcorn, Caroline J., Robert J. Simpson, David Leahy, and Timothy J. Peters. "In vitro studies of intestinal drug absorption." Biochemical Pharmacology 42, no. 12 (1991): 2259–64. http://dx.doi.org/10.1016/0006-2952(91)90228-w.

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39

Casadei, G., E. Grilli, and A. Piva. "Pediocin A modulates intestinal microflora metabolism in swine in vitro intestinal fermentations." Journal of Animal Science 87, no. 6 (2009): 2020–28. http://dx.doi.org/10.2527/jas.2008-1438.

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40

Subramanian, U., and A. E. Ahmed. "Intestinal Toxicity of Acrylonitrile: In Vitro Metabolism by Intestinal Cytochrome P450 2E1." Toxicology and Applied Pharmacology 135, no. 1 (1995): 1–8. http://dx.doi.org/10.1006/taap.1995.1202.

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41

Tirelle, P., J. Breton, A. Kauffmann, et al. "La déplétion du microbiote intestinal induit une réponse sexe-dépendante au modèle d’activity-based anorexia." Nutrition Clinique et Métabolisme 34, no. 1 (2020): 36. http://dx.doi.org/10.1016/j.nupar.2020.02.235.

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42

Reddy, Micaela B., Michael B. Bolger, Grace Fraczkiewicz, et al. "PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates." Pharmaceutics 13, no. 9 (2021): 1325. http://dx.doi.org/10.3390/pharmaceutics13091325.

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Uridine 5′-diphospho-glucuronosyltransferases (UGTs) are expressed in the small intestines, but prediction of first-pass extraction from the related metabolism is not well studied. This work assesses physiologically based pharmacokinetic (PBPK) modeling as a tool for predicting intestinal metabolism due to UGTs in the human gastrointestinal tract. Available data for intestinal UGT expression levels and in vitro approaches that can be used to predict intestinal metabolism of UGT substrates are reviewed. Human PBPK models for UGT substrates with varying extents of UGT-mediated intestinal metabol

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43

Larsen, Christian-Jacques. "Sphéroïdes : le modèle de référence pour la culture in vitro des tumeurs solides ?" Bulletin du Cancer 105, no. 1 (2018): 25–34. http://dx.doi.org/10.1016/j.bulcan.2017.09.008.

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44

Blank, U., and N. Varin-Blank. "La lignée mastocytaire RBL : modèle expérimental in vitro et application en pharmacologie clinique." Revue Française d'Allergologie et d'Immunologie Clinique 44, no. 1 (2004): 51–56. http://dx.doi.org/10.1016/j.allerg.2003.10.009.

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45

Seko, Yoshiyuki, Masako Takahashi, Tatsuya Hasegawa, and Teiji Miura. "Intestinal Absorption of Mercury in Vitro from Intestinal Contents of Methylmercury Administered Mice." JOURNAL OF HEALTH SCIENCE 47, no. 5 (2001): 508–11. http://dx.doi.org/10.1248/jhs.47.508.

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46

Michiba, Kazuyoshi, Kengo Watanabe, Tomoki Imaoka, and Daisuke Nakai. "Recent Advances in the Gastrointestinal Complex in the Vitro Model for ADME Studies." Pharmaceutics 16, no. 1 (2023): 37. http://dx.doi.org/10.3390/pharmaceutics16010037.

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Intestinal absorption is a complex process involving the permeability of the epithelial barrier, efflux transporter activity, and intestinal metabolism. Identifying the key factors that govern intestinal absorption for each investigational drug is crucial. To assess and predict intestinal absorption in humans, it is necessary to leverage appropriate in vitro systems. Traditionally, Caco-2 monolayer systems and intestinal Ussing chamber studies have been considered the ‘gold standard’ for studying intestinal absorption. However, these methods have limitations that hinder their universal use in

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47

Jin, Hye-Rin, Jin Yu, and Soo-Jin Choi. "Hydrothermal Treatment Enhances Antioxidant Activity and Intestinal Absorption of Rutin in Tartary Buckwheat Flour Extracts." Foods 9, no. 1 (2019): 8. http://dx.doi.org/10.3390/foods9010008.

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Tartary buckwheat (Fagopyrum esculentum) is widely used in the food industry due to its functionality, which is related to its high rutin content. However, rutin is easily converted into quercetin by an endogenous enzyme during processing, resulting in a bitter taste. In this study, rutin-enriched Tartary buckwheat flour extracts (TBFEs) were obtained by hydrothermal treatments (autoclaving, boiling, and steaming), and their antioxidant activity was evaluated in human intestinal cells. The intestinal absorption of the hydrothermally treated TBFEs was also investigated using in vitro models of

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48

Leblanc, A., C. Blondeau, S. Holowacz, C. Langlois, and L. Haddioui. "Effet synergique d’extraits de cannelle et de canneberge sur l’inhibition de l’adhésion d’Escherichia coli uropathogène aux cellules épithéliales de la vessie." Phytothérapie 17, no. 4 (2019): 196–200. http://dx.doi.org/10.3166/phyto-2019-0178.

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L’effet inhibiteur des proanthocyanidines (PACs) de type A de la canneberge sur l’adhésion d’Escherichia coli aux cellules uroépithéliales est bien documenté. Cette adhésion étant une des étapes précoces des infections urinaires (IU), la canneberge est utilisée dans la prévention de ces infections. La cannelle étant une autre source alimentaire de PACs de type A, nous avons testé son potentiel antiadhésif dans un modèle in vitro de cellules épithéliales de vessie humaine (lignée cellulaire T24). Dans ce modèle, un extrait de cannelle de Ceylan standardisé à plus de 8 % de PACs de type A2 a inh

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49

Yoon, Jungbin, Narendra K. Singh, Jinah Jang, and Dong-Woo Cho. "3D bioprinted in vitro secondary hyperoxaluria model by mimicking intestinal-oxalate-malabsorption-related kidney stone disease." Applied Physics Reviews 9, no. 4 (2022): 041408. http://dx.doi.org/10.1063/5.0087345.

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Secondary hyperoxaluria (SH) is a multifactorial disorder that extends from inflamed intestinal epithelium with oxalate malabsorption to kidney stone disease; its prevalence is increasing annually. Studying complex SH has been a considerable challenge because of the lack of an in vitro multiorgan model that describes dynamic pathophysiological interactions between the native intestinal epithelium and proximal tubule (PT). An in vitro multiorgan model is developed using a multi-biofabrication technique to address this challenge; this developed microfluidic in vitro multiorgan model demonstrates

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50

van de Kerkhof, Esther, Inge de Graaf, and Geny Groothuis. "In Vitro Methods to Study Intestinal Drug Metabolism." Current Drug Metabolism 8, no. 7 (2007): 658–75. http://dx.doi.org/10.2174/138920007782109742.

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