Dissertations / Theses on the topic 'Modelli di valutazione'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Modelli di valutazione.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Annecchini, Andrea. "Valutazione di derivati Americani in modelli multi-dimensionali." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/20743/.
Full textPirazzini, Serena. "Implementazione e valutazione di modelli di mobilità sulla piattaforma GAIA/ARTIS." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3116/.
Full textMazzai, Francesco <1982>. "Modelli semplificati per valutazione di vulnerabilità sismica di strutture in muratura." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5936/1/Mazzai_Francesco_tesi.pdf.
Full textThe aim of the thesis was to investigate complex problem of seismic vulnerability of masonry arch bridge by using simplified models. After a description of construction materials used in building and the principals element of a masonry bridges, the study on the arch bridge located in the municipality of San Marcello Pistoiese is reported. Numerical model, that allows to describe the structural behaviour of the bridge under seismic action and to assess the carrying capacity of the bridge subjected to a transversal action, is shown. In second moment the construction of a scale model of the bridge is described, it was subjected destructive tests made to assess the carrying capacity of the bridge compared to a hypothetical seismic action. It tries to frame the issue in a theoretical model that refers to the analysis limit. It describes a kinematics collapse of the chassis which takes its inspiration from the crack of the masonry model. FEM numerical models are presented in order of increasing complexity, seeking to frame the mechanical behaviour of the prototype of the bridge. Three types of models are shown: the first is represented by a frame consisting of linear beam elements with bending resistance hinged at the ends. The second type consists of a reticular frame equivalent in roughly the trends of the bridge and is formed only of rod-free flexural behaviour. Finally, the third type tries to describe the entire model with three-dimensional elements.
Mazzai, Francesco <1982>. "Modelli semplificati per valutazione di vulnerabilità sismica di strutture in muratura." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5936/.
Full textThe aim of the thesis was to investigate complex problem of seismic vulnerability of masonry arch bridge by using simplified models. After a description of construction materials used in building and the principals element of a masonry bridges, the study on the arch bridge located in the municipality of San Marcello Pistoiese is reported. Numerical model, that allows to describe the structural behaviour of the bridge under seismic action and to assess the carrying capacity of the bridge subjected to a transversal action, is shown. In second moment the construction of a scale model of the bridge is described, it was subjected destructive tests made to assess the carrying capacity of the bridge compared to a hypothetical seismic action. It tries to frame the issue in a theoretical model that refers to the analysis limit. It describes a kinematics collapse of the chassis which takes its inspiration from the crack of the masonry model. FEM numerical models are presented in order of increasing complexity, seeking to frame the mechanical behaviour of the prototype of the bridge. Three types of models are shown: the first is represented by a frame consisting of linear beam elements with bending resistance hinged at the ends. The second type consists of a reticular frame equivalent in roughly the trends of the bridge and is formed only of rod-free flexural behaviour. Finally, the third type tries to describe the entire model with three-dimensional elements.
Tonin, Talita <1989>. "Valutazione di opere cinematografiche: metodi a confronto." Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/10726.
Full textColonnelli, Michela. "Studio, sviluppo e valutazione di modelli di contrattilità cardiaca in fibrillazione atriale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/17180/.
Full textMasaro, Luca <1991>. "Vantaggio competitivo e aspettative di crescita nei modelli di valutazione asset-side." Master's Degree Thesis, Università Ca' Foscari Venezia, 2015. http://hdl.handle.net/10579/7270.
Full textCHIAF, ELISA. "LE IMPRESE SOCIALI DI INSERIMENTO LAVORATIVO E LA CREAZIONE DI VALORE: MODELLI DI VALUTAZIONE." Doctoral thesis, Università Cattolica del Sacro Cuore, 2010. http://hdl.handle.net/10280/752.
Full textWork Integration Social Enterprises (WISEs) are very well known in Europe and they are recognized as important actors to promote the active inclusion of disadvantaged people, disabled, homeless, migrants, unemployed, people with disadvantages and minorities, to avoid their discrimination both in work labour and in the society. Work Integration issue is nowadays a relevant theme that considers social matters together with human rights’ respect, equality, freedom and self-determination. There is the lack of a complete evaluation scheme that could give a whole perspective of WISEs' results. For them there are features and management ties that require methods wider than the economic ones disclosed in the financial report, in order to measure the created value for the Public Administration and community. The PhD work focuses on the creation of a possible evaluation model to apply to WISE. A WISEs’ sample has been selected to understand which elements were difficult to measure and, after the definition of the model it has been directly tested. Local WISEs and institutions have been actively involved in the executions. The main result is the participative creation process of an instrument that evaluates WISEs’ value for the community, through the analysis of their external effect on public budget.
CHIAF, ELISA. "LE IMPRESE SOCIALI DI INSERIMENTO LAVORATIVO E LA CREAZIONE DI VALORE: MODELLI DI VALUTAZIONE." Doctoral thesis, Università Cattolica del Sacro Cuore, 2010. http://hdl.handle.net/10280/752.
Full textWork Integration Social Enterprises (WISEs) are very well known in Europe and they are recognized as important actors to promote the active inclusion of disadvantaged people, disabled, homeless, migrants, unemployed, people with disadvantages and minorities, to avoid their discrimination both in work labour and in the society. Work Integration issue is nowadays a relevant theme that considers social matters together with human rights’ respect, equality, freedom and self-determination. There is the lack of a complete evaluation scheme that could give a whole perspective of WISEs' results. For them there are features and management ties that require methods wider than the economic ones disclosed in the financial report, in order to measure the created value for the Public Administration and community. The PhD work focuses on the creation of a possible evaluation model to apply to WISE. A WISEs’ sample has been selected to understand which elements were difficult to measure and, after the definition of the model it has been directly tested. Local WISEs and institutions have been actively involved in the executions. The main result is the participative creation process of an instrument that evaluates WISEs’ value for the community, through the analysis of their external effect on public budget.
Bovo, Marco <1983>. "Valutazione della risposta sismica di edifici mediante modelli anelastici equivalenti." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5926/1/Bovo_Marco_Tesi.pdf.
Full textA new methodology for the study and evaluation of the seismic response of buildings is presented. The method involves the use of non-linear time-history analysis on equivalent MDOF stick models, according to the classification given in Report FEMA 440. The steps for implementing the method are described in the thesis. For the validation of the methods the results obtained were compared to that obtained by time-history analysis on detailed three-dimensional models of the structures studied (detailed model). The engineering parameters considered in the comparison, in order to use the proposed method in a Displacement-Based Design approach, are the top displacements, the inter-storey drifts, the forces at the floor and the base shear. The results of the conducted analyzes, on the equivalent stick models, match satisfactorily, in an excellent way in certain cases, those of the analyzes carried out on detailed model. The time-history on the stick model, however, allow a considerable saving in terms of computational effort and time for the post-processing of results.
Bovo, Marco <1983>. "Valutazione della risposta sismica di edifici mediante modelli anelastici equivalenti." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5926/.
Full textA new methodology for the study and evaluation of the seismic response of buildings is presented. The method involves the use of non-linear time-history analysis on equivalent MDOF stick models, according to the classification given in Report FEMA 440. The steps for implementing the method are described in the thesis. For the validation of the methods the results obtained were compared to that obtained by time-history analysis on detailed three-dimensional models of the structures studied (detailed model). The engineering parameters considered in the comparison, in order to use the proposed method in a Displacement-Based Design approach, are the top displacements, the inter-storey drifts, the forces at the floor and the base shear. The results of the conducted analyzes, on the equivalent stick models, match satisfactorily, in an excellent way in certain cases, those of the analyzes carried out on detailed model. The time-history on the stick model, however, allow a considerable saving in terms of computational effort and time for the post-processing of results.
Martino, Fausta <1979>. "La valutazione di modelli e sperimentazioni di progettazione partecipata sociale e socio-sanitaria." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7304/1/martino_fausta_tesi.pdf.
Full textUp until today, social services have offered reparatory interventions and activities, which caused fragmentation of requests and therefore individualisation of the offer. The objective of this research is to explore different cases, with a perspective focused on a micro-level i.e. how participatory processes are started in the field of social and social health services in ecological and not necessarily administrative units, through good participatory practices characterised by their own evaluation. This research has been made in collaboration with “Agenzia sociale e sanitaria della regione Emilia Romagna”.
Martino, Fausta <1979>. "La valutazione di modelli e sperimentazioni di progettazione partecipata sociale e socio-sanitaria." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7304/.
Full textUp until today, social services have offered reparatory interventions and activities, which caused fragmentation of requests and therefore individualisation of the offer. The objective of this research is to explore different cases, with a perspective focused on a micro-level i.e. how participatory processes are started in the field of social and social health services in ecological and not necessarily administrative units, through good participatory practices characterised by their own evaluation. This research has been made in collaboration with “Agenzia sociale e sanitaria della regione Emilia Romagna”.
Barni, Margherita. "Valutazione delle incertezze derivanti dall'impiego di diversi modelli costitutivi per la valutazione della risposta sismica di telai in c.a." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Find full textALDRIGHETTI, GIANLUCA. "VALUTAZIONE DI VULNERABILITA’ SISMICA DI ELEMENTI IN C.A.: MODELLI DI CAPACITA’ A FLESSIONE E TAGLIO." Doctoral thesis, Università IUAV di Venezia, 2021. http://hdl.handle.net/11578/306142.
Full textCalabritto, Alessandro. "Prove di vita accelerate e modelli matematici per la valutazione dell'affidabilità." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/5720/.
Full textMagro, Stefania <1985>. "Modelli jump diffusion per la valutazione di opzioni europee ed americane." Master's Degree Thesis, Università Ca' Foscari Venezia, 2013. http://hdl.handle.net/10579/3330.
Full textHAZIM, MOUHAMAD BACHIR. "Studio e valutazione di tecnologie e processi organizzativi per l'adozione di servizi di manutenzione innovativi." Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/270345.
Full textNowadays, companies find themselves working in a market characterized by a climate of uncertainty: customer needs change quickly and the markets are becoming more and more competitive. It is therefore important for companies to find ways to adapt with a certain reactivity, in order not to be overcome by the competition. Parallel to the evolution of the markets, there is an explosion in the amount of information that can be found both inside and outside the boundaries of the company, which is facilitated by the spread of computer networks and distributed systems, the first among them being the Internet. The need to manage information in a rational and organic way and the prospect of having to supply increasingly personalized goods and services, has led the companies to review their processes and their way of operating by relying on information systems. These are no longer simple information management software programs, but real active tools, a source of competitive advantage. We are talking about ERP, Enterprise Resource Planning, IT packages capable of integrating all the operational and administrative processes on a corporate basis. Integrated functionality systems supporting not only planning, but the entire decision-making dimension: they support business management in all its areas, from accounting to personnel management, from customer relations to suppliers and warehouses. Integration is possible not only thanks to particular (certain se vuoi lasciare particular sotto) software architectures, but also thanks to the fact that ERPs incorporate the "best practices", i.e. the most common process practices found/employed in excellent companies. More precisely, most of the most widespread systems consist of a central software core and the possibility of adding optional peripheral software modules, each concerning the management of a particular specific business area of defined competences (e.g. accounting, materials management, planning, production, etc.). Implementing an ERP system means "rethinking and changing" a company's way of acting; as a matter of fact, a transformation of a company involves an operational, strategic and inter-company plan. Thanks to the prescriptive feature, ERPs impose on the company a set of procedures that become simple and linear routines, eliminating the barriers between functions, and make the organization more agile and reactive. The implementation activity is very critical and delicate and can take a very long time, sometimes even more than 20 months. Other aspects that express the criticality of the project are the high costs to be incurred, the inclusion of the people involved in the process/project and the possibility of failure. Bearing in mind the above-described factors, in the first and second part of the thesis the concept of the ERP system will be studied in depth, defining its structure, evolution, advantages, limits and implementation phases, with particular reference to the process Reengineering phase, i.e. the redesign of the business processes. Finally, in the third and last part of the thesis, the project carried out at the companies of the "Bronzini Group" during the research doctorate will be presented. The project was developed as follows: In the first year: in-depth study of the currently available techniques, in order to understand how to improve them or replace them with innovative techniques. In the second year: configuration of the information system necessary for the implementation of these techniques and/or new techniques designed ad hoc into the business. In the third year: the implementation and subsequent analysis of the results achieved. This case study describes a project aimed at introducing a new latest-generation computer system with high-performance hardware, software (ERP) from the Microsoft Dynamics Navision 2015 package, capable of synergistically integrating all business processes and interconnections with the online world, which provides for a complete implementation in 2019. The analysis of the paper proposes an in-depth study of the situation in which the company presents itself, both in terms of activity and information, thus obtaining a “map” of the existing processes (called AS-IS). Thus, the needs and criticalities of the current management of the activities are noted, in order to outline the objectives to be pursued through the implementation of the new ERP system (TO-BE analysis). Finally, the GAP ANALYSIS is presented, as a comparison of the difference between the starting situation with the old management and the future perspective with the new solution adopted by the company. By implementing/using a new management system, the "Bronzini Group" aims to extend the process control to all the business areas involved and improve the entire flow of order management, from budgeting to invoicing and subsequent archiving and historical data management. The ultimate goal is to be able to provide a new tool in which all information is available to the people involved in the process/project, in order to optimize time and results and guarantee safety at work. Adapting innovative processes allows to obtain. • Reduction of the resources consumed, therefore also a cost reduction; • Reduction of the time of necessary for the execution of maintenance processes; • Improvement of the operativity/effectiveness of specialized personnel, also from the point of view of operational safety; • Improvement of the customers’ assets undergoing maintenance, in terms of efficiency and environmental sustainability, productivity and safety at work; • Improvement of the overall service rendered to the customer, in terms of quality and professionalism, with consequent increase in competitiveness. Until a few years ago, companies were practically forced to create their information software like a tailored suit, commissioning software houses for that job, while today the case of purchasing “pre-packaged” ERP packages adaptable to the company’s needs through a process of "parameterization" is prevalent. The advantages offered by the latter are considerable, since the proposed solutions are the result of in-depth studies and advanced theories of information and management and, above all, have already been tested in other companies. The fixed costs of design and development are divided based on the number of packages produced and do not fall entirely on the ordering company. In the design and development of their products, the manufacturers of ERP consider the company as a whole and its processes, and not the individual functions, as was the case with the vast majority of software created ad hoc by smaller companies. Starting from these assumptions it is clear why it is noted that large companies are definitely moving towards the standard industrialized ERP systems. This is not the case with small companies, which prefer to purchase non-ERP systems and have tailor-made systems built by minor software houses at much lower costs than the “big” ERP. Small and medium-sized companies are therefore faced with the most difficult choice: having to decide whether to adopt a customized system or an ERP package. However, it is important for these companies to understand that, with the same functionality, a system custom-built by a software house certainly costs more than an equivalent pre-packaged one (meglio one se non è proprio necessario dire package, cioè se in questo caso sistema e pacchetto sono la stessa cosa). Starting from this consideration, it is clear that spending more money on an ERP system than on an ad hoc system means having a much higher number of features. These may seem superfluous at the time of purchase, but they are actually a guarantee of support for when the company has grown. Therefore, in the comparison between industrialized ERPs and specific tailor-made systems, it is necessary to take into account not only the cost, but also the opportunities represented and the investments that the company will have to sustain in the future to equate the functions of a specific system with those that an ERP system already contains. Some market researches certainly small and medium-sized companies in this direction and that is why all the major ERP manufacturers have already started to contend for this market sector. Having made the appropriate economic assessments and having taken the decision of which system to adopt, the real critical point, important to highlight in this work, is that, when choosing an ERP system to introduce into the company, it is not easy to immediately evaluate all the advantages because the results are not immediate either. My experience in the “Bronzini Group” goes precisely in this direction: having made the appropriate economic assessments, the decision was taken to adopt an ERP system designed to "adapt" to the needs of the company and therefore flexible and able to improve everything that revolves around each individual business process, including an increase in the company knowledge. However, with the non-immediate results and some problems that arose at the time of the introduction into the business, new needs not foreseen in the initial project arose continuously. This is because reproducing a company system on "paper" is one thing, but reproducing it in the new reality is another. Not all the problems can be foreseen and therefore the fundamental factor must be the ability to be able to manage the new critical issues, relying on reliable partners and trusting in a prepared and solid company structure. Regarding the choice of a reliable partner: the preliminary analysis carried out is adequate and with a very high degree of detail. The expected benefits reflect the mission, which, in fact, places the priority on transforming the need to respond to new market requirements into opportunities for renewal, and it is through the use of a new ERP that the “Bronzini Group” aims to improve its business and increase its competitive capacity in the long term despite the implementation difficulties that this ERP entails. Microsoft Dynamics, for example is a relatively simple system both in terms of installation and use because it maintains the operating logic of all Microsoft software that is distributed on a global scale and that everyone is already familiar with. On the other hand, however, even though the functions provided by Dynamics are numerous, it is not possible to model all the business processes through this ERP. All things considered, Microsoft Dynamics turns out to be a fairly stable system, light and easy to use, perfectly integrated with all Microsoft tools (e.g. Office) and does not require months of training for an operator to be able to use it. Installing an ERP system involves a number of factors that are to be considered at the time of purchase since it is not a simple software that is installed on the client side, the license is paid, and everything is solved. The installation of an ERP system requires an analysis of business processes in order to model them, and this implicates a big change in the work methodology of the company, which, however, is necessary to obtain a good competitive advantage in terms of profit margins. It is fundamental to understand first what is more convenient: a light system with less functionality or one that is complete but more complex to use – if this analysis is not done on time, there is a great risk of losing a lot of money. Another aspect that is not to be underestimated is the pre-implementation phase, where it is critical to identify the needs (analysis of business processes) that should be fulfilled. If from the beginning, during the planning phase, a careful analysis of one's own needs is carried out, involving the main corporate figures, one can be sure that the probability of successful introduction of the ERP will be high. The critical point of the project was in fact the involvement of the company staff in the analysis and the modification/improvement phase of the business processes because it had such an innovative and revolutionary impact on the existing operating structure that it was not always easy to involve the corporate figures responsible for the process in the right way. The implementation project for a new innovative integrated information system has involved performing a series of internal "research and development" activities in collaboration with external Logical System personnel aimed at: a) design and development of new innovative processes b) acquisition, combination, structuring and use of existing scientific, technological and commercial knowledge and skills in order to produce plans, projects or designs for new, modified or improved products, processes or services. The project was born from the company's need to computerize various processes, in order to automate and standardize information flows, save time, minimize errors and eliminate all the customization of documentation, descriptions and procedures inherent in manual management. When the project was started, and still, in the current state of the art, on the market, there is no system capable of covering all the activities that the “Bronzini Group” manages, which are different for each area of activity. Therefore, the only viable solution for computerization was, and remains, to develop a customized system. We are moving from an "information technology" characterized by a scarcity of data, to a new and innovative one that has an abundance of data, which can be increasingly acquired automatically, with speed of exchange and communication in exponential growth, and with globalized access to information. Furthermore, the type of information handled is also changing significantly. Today, the information is all multimedia and hypermedia – that is a composition of information elements of different types (text, images, videos, sounds, procedures, programs and so on) – and these information aggregates can be interconnected with each other by creating a semantic network with high complexity and without dimensional limits, which can also bring hidden aspects to the surface, in essence it can make knowledge emerge automatically. Finally, we cannot overlook the fact that the current automated systems are no longer limited to the task of preserving bits, which must however be interpreted by "humans" so that they are recognized as information. The current automated systems can now act on the basis of the information already present in the system and processed automatically, producing a direct impact on the reality of the "humans", without their aid. Today the project has led to the development of new, completely innovative technical solutions that are already having a very significant impact in the management process of the various branches of activity of the company, especially in the maintenance sector. The project involved: - Internal resources of all the various company areas, for the analysis of the flows and the design of the block diagrams of the various specific procedures; - Technical and project management sectors, for the software development; - External IT consultants, for the design of the software, platforms and interfaces. The project, started in 2015, is currently in full development phase. Given the enormous investment already made in this area and considering that there is no tool on the market able to satisfy all the needs of their business, the company has anyway deemed appropriate to invest additional resources in developing the system so that it works correctly and effectively and automates all business processes in the medium/long term.
Mariotti, Gianluca. "Valutazione delle caratteristiche dei modelli di previsione degli impatti odorigeni di tipo gaussiano e lagrangiano." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16995/.
Full textScandellari, Carolina. "Algortimi di spike detection per applicazioni neuroprotesiche: sviluppo di modelli, implementazione e valutazione delle performance." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/19904/.
Full textMenegaldo, Ludovica <1987>. "Strumenti per la valutazione degli artisti di arte contemporanea: diversi modelli di ranking a confronto." Master's Degree Thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/1778.
Full textCURIONI, SUSANNA. "Paesaggio e trasformazione. Metodologie di lettura e valutazione per nuovi modelli organizzativi." Doctoral thesis, Università degli Studi di Cagliari, 2015. http://hdl.handle.net/11584/266798.
Full textVandelli, Davide. "Procedura per l’applicazione di modelli di dispersione degli inquinanti in atmosfera nell’ambito della valutazione d’impatto ambientale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/23818/.
Full textCastelli, Claudia. "Valutazione dell’efficacia di barriere chimiche contro l’umidita’ da risalita capillare nelle murature mediante modelli di laboratorio." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016.
Find full textFERRARIO, MATTEO. "VALUTAZIONI ECONOMICHE A SUPPORTO DEI PROCESSI DI VALUTAZIONE DI FARMACI PER MALATTIE RARE IN ITALIA: IL CASO DELL’ATROFIA MUSCOLARE SPINALE." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/404614.
Full textThe use of economic assessments in the health sector has assumed a role of increasing importance over the years, in light of the need to provide useful information to decision-makers in the difficult role of continuing to guarantee innovation in contexts of scarce resources, in a universalistic system. Decision models, both decision trees or Markov models, are tools that demonstrate that they most often respond to the need to simulate the course of a disease and the effect of treatments on it, producing estimates on final outcomes and costs in the long term that feed cost-effectiveness / cost-utility indicators, used, albeit with different logics, by various HTA agencies to define the economic value of a new technology and support price negotiations. In addition to cost-effectiveness / utility models, the simplest budget impact models find considerable space in this context, providing crucial information regarding the sustainability of the system. AIFA which analyzes and uses them within the investigations submitted to the Price and Reimbursement Committee (CPR) for the definition of the price and reimbursement conditions for drugs. These evaluations are also particularly recommended in those particularly complex decision-making areas, such as the case of orphan drugs / for rare diseases. in this work, the specific case of spinal muscular atrophy and the medicinal product risdiplam, as an example of a rare disease in which disruptive innovation has entered in recent years and where therefore the decision-makers have found themselves (and still are) to have to carefully evaluate the impacts both from a clinical point of view and from an organizational and economic point of view, in an HTA logic. The work carried out involved the development of three different types of analyzes whose integrated reading alone allows for an overall picture of the elements of allocative efficiency and sustainability impact required by AIFA for its evaluations of access to drugs. The first analysis performed was a cost-utility analysis in patients with SMA 1, in which the new drug demonstrated a favorable profile, with a cost / QALY indicator gained of approximately € 43,000 in the lifetime scenario, which falls within commonly defined acceptability thresholds. In the 5 and 10 year scenarios, risdiplam proved to be cost saving compared to the alternative. The second evaluation carried out was a cost-minimization analysis in patients with SMA 2 and 3, which showed an economic convenience of about € 160,000 over 10 years, considering both pharmacological and administration costs. Finally, a budget impact analysis was carried out in which, following the introduction of risdiplam in the market, an incremental spending impact is not estimated due to a cost reduction in SMA 1 and 3 which offsets the expected increase in SMA 2. The integrated reading of the results of the three models developed finds profound coherence in having negotiated a new therapy with cost-utility ranges consistent with those currently cited in other countries and financial impact parameters compatible with the further aggravate on the NHS.
Pieri, Giulia <1981>. "L'ospedale di comunità nella regione Emilia-Romagna: modelli organizzativi e valutazione della qualità dell'assistenza." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7368/1/PIERI_GIULIA_tesi.pdf.
Full textThe fragmentation of services for elderly with multimorbidity and frailty does guarantee neither effective and efficient care, nor the satisfaction of patients and their families. At international level, for decades, organizational models for “intermediate care” have been developing, as solution to emerging problems (aging, chronic disease, multiborbidity and frailty), to avoide inappropriate hospital admission and to delay long-term care. Consistent with national documents, Emilia-Romagna Region has been redefining community services and the acute hospital network with the aim of ensuring continuity of care and integration between hospital and community services, especially for people with chronic diseases, developing intermediate care and activating bed-based intermediate care services (Community Hospitals). The research project aimed to define – through the identification and analysis of specific indicators – a structured method for monitoring health care provided to patients in Community Hospitals in terms of clinical, organizational and patient perspective. The organizational model has been examined comparing three Community Hospital of Emilia-Romagna Region. Indicators have been analyzed to describe patients discharged from the Community Hospital of Castel San Pietro Terme (Imola Local Health Authority). The structured analysis and the identification of emerging clusters of patients admitted in Community Hospital, could provide important input for the best planning of integrated care pathways for patients. The description of clinical pathway of patients admitted in Community Hospitals may help to better define organizational strategies for both acute and community care, both health and social assistance, to enhance responses to patients' needs.
Pieri, Giulia <1981>. "L'ospedale di comunità nella regione Emilia-Romagna: modelli organizzativi e valutazione della qualità dell'assistenza." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7368/.
Full textThe fragmentation of services for elderly with multimorbidity and frailty does guarantee neither effective and efficient care, nor the satisfaction of patients and their families. At international level, for decades, organizational models for “intermediate care” have been developing, as solution to emerging problems (aging, chronic disease, multiborbidity and frailty), to avoide inappropriate hospital admission and to delay long-term care. Consistent with national documents, Emilia-Romagna Region has been redefining community services and the acute hospital network with the aim of ensuring continuity of care and integration between hospital and community services, especially for people with chronic diseases, developing intermediate care and activating bed-based intermediate care services (Community Hospitals). The research project aimed to define – through the identification and analysis of specific indicators – a structured method for monitoring health care provided to patients in Community Hospitals in terms of clinical, organizational and patient perspective. The organizational model has been examined comparing three Community Hospital of Emilia-Romagna Region. Indicators have been analyzed to describe patients discharged from the Community Hospital of Castel San Pietro Terme (Imola Local Health Authority). The structured analysis and the identification of emerging clusters of patients admitted in Community Hospital, could provide important input for the best planning of integrated care pathways for patients. The description of clinical pathway of patients admitted in Community Hospitals may help to better define organizational strategies for both acute and community care, both health and social assistance, to enhance responses to patients' needs.
Toffan, Anna. "Influenza aviaria: valutazione della patogenicità e trasmissibilità di virus H7N1 italiani in modelli animali." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3427204.
Full textI virus dell’influenza aviaria, soprattutto quelli ad alta patogenicità, rappresentano un serio problema per la sanità animale ed umana. Negli ultimi dieci anni, infatti, un netto aumento dei focolai di influenza aviaria ha coinvolto in tutto il mondo i volatili selvatici ma soprattutto il pollame domestico con un impatto economico enorme per il settore avicolo dovuto alla morte e/o abbattimento di migliaia di volatili. Inoltre molti di questi virus sono stati in grado di superare le barriere di specie infettando i mammiferi ed in particolare l’uomo. In molti casi l’infezione nell’uomo si è risolta con una sindrome simil-influenzale o con forme di congiuntivite, ma in altrettanti casi ha portato al decesso dei soggetti infetti. La presente tesi ha lo scopo di approfondire alcuni aspetti legati alla patogenicità e trasmissibilità dei virus dell’influenza aviaria in modelli animali. Per effettuare gli esperimenti descritti nella presente tesi, sono stati scelti ed utilizzati virus dell’influenza aviaria di sottotipo H7, che sono molto diffusi in tutto il modo e sono stati causa di alcuni dei focolai di malattia più gravi che si ricordino, come l’epidemia italiana del 1999-2000. In particolare, per aumentare le informazioni disponibili relativamente al rischio di contaminazione delle carni e dei prodotti derivati da avicoli infetti, è stata effettuata una infezione sperimentale con virus H7N1 ad alta e bassa patogenicità in tacchini vaccinati e non. Lo scopo dell’infezione è stato quello di determinare la capacità di diffusione dei virus H7N1 HPAI e LPAI nei tessuti muscolari e nel sangue di tacchino e di valutare l’efficacia della vaccinazione nel prevenirla. Infine è stato valutato anche il rischio di infezione del pollame connesso al consumo di carni simulando un pasto di carne infetta. I risultati ottenuti hanno dimostrato come il virus HPAI si ritrovi costantemente nel sangue e nei muscoli degli animali non vaccinati ed infetti, mentre il virus LPAI è stato ritrovato a basso titolo solo nel sangue di un soggetto non vaccinato e solo tramite la RRT-PCR nei muscoli di alcuni altri soggetti non vaccinati. La vaccinazione si è dimostrata quindi molto efficace nel prevenire l’instaurarsi della viremia e quindi della diffusione del virus nelle carni in animali infettati sia con virus ad alta che a bassa patogenicità. Non è stata rilevata infine infezione nei soggetti nutriti con il muscolo infetto e pertanto il rischio di diffusione della malattia connesso a questa pratica sembra essere ridotto. Ulteriori esperimenti sono stati effettuati per approfondire il rischio zoonosico dei virus H7N1 HPAI italiani nel mammifero utilizzando come modello il topo. In particolare sono stati selezionati alcuni virus H7N1 per infettare gruppi di topi per via nasale. Infatti le sequenze geniche effettuate sui virus isolati in Italia nel 1999-2000 hanno evidenziato un isolato da struzzo (Struthio camelus) caratterizzato dalla presenza di una lisina in posizione 627 del gene codificante per la proteina PB2. Questa mutazione è estremamente rara negli isolati di origine aviari, che generalmente presentano in tale posizione un acido glutammico, e sembra influenzare in modo determinante la patogenicità virale. I dati ottenuti durante questa infezione sperimentale hanno dimostrato che i virus che posseggono tale mutazione hanno un’aumentata patogenicità per il topo caratterizzata da marcato neuro e pneumotropismo. Infine, a causa della carenza di dati relativi alla capacità di trasmettersi di questi virus nel topo, è stato sviluppato un modello sperimentale per valutare la trasmissibilità di virus H7N1 HPAI nell’ospite murino. E’ stata dimostrata quindi per la prima volta la capacità di tali virus di trasmettersi da topi infetti a topi sentinella sani posti a diretto contato con essi. La trasmissione è avvenuta a causa del contatto con le secrezioni nasali di soggetti infettati sperimentalmente che si sono dimostrate particolarmente cariche di virus. I dati prodotti dalle infezioni sperimentali effettuate, quindi, sottolineano ancora una volta come i virus influenzali H7N1 siano caratterizzati da una elevata patogenicità sia per l’ospite aviario (tacchino) che per l’ospite mammifero (topo). Il potenziale zoonotico di questi virus non è da sottovalutare, data anche la loro capacità di trasmettersi da topi infetti a topi sani. La vaccinazione infine appare essere un valido strumento di lotta alla diffusione dei virus influenzali aviari nei volatili e quindi di prevenzione del rischio connesso alla loro capacità di infettare nuovi ospiti e di acquisire mutazioni potenzialmente pericolose.
LECCI, MATTIA. "Valutazione e Miglioramenti di Modelli, Protocolli e Sistemi per Wi-Fi in banda mmWave." Doctoral thesis, Università degli studi di Padova, 2022. http://hdl.handle.net/11577/3447673.
Full textThe 5th Generation (5G) of communication networks is currently being deployed, promising better than ever capacity, responsiveness, and coverage. Many new technologies, as well as evolutions of old technologies, have been harvested to improve over the previous generation, such as the usage of high frequencies commonly known as the MilliMeter Wave (mmW) band. These new bands, typically ranging between 6~and 100~GHz, have long been studied, trying to overcome many of their peculiarities such as (i) low range due to high free-space propagation loss, (ii) high susceptibility to blockage, and (iii) sparse directionality, among others. In this thesis, we analyze and propose models that allow more in-depth studies on next-generation networks on different levels. Aiming to improve the next-generation IEEE~802. 11 standards, also known as Wireless Gigabit (WiGig), we focused mainly on full-stack network simulations, given the higher degree of realism with respect to mathematical models, and the much lower cost and flexibility with respect to hardware testbeds. We were able to improve and create models ranging across almost all levels of the communication stack, from the Physical (PHY) up to the Application (APP) layers. This allowed us to obtain a holistic view of the mmW-based network, making us able to design and characterize better models. Starting from the mmW channel itself, we will describe our proposals to modify well-known channel models to improve simulation performance and extend network analysis to scenarios that were never explored before, due to a lack of available tools. Antenna models were studied, and, with the help of machine learning techniques, optimal configurations specific for the mmW band were obtained. Moving towards the WiGig protocol stack, works have been done on the optimization of Medium Access Control (MAC)-layer scheduling algorithms, specifically tailored for quasi-periodic applications. Finally, we analyzed, characterized, and modeled eXtended Reality (XR) traffic, one of the most prominent types of quasi-periodic applications that are forseen to be largely used in 5G networks.
Cimatti, Luca. "Utilizzo di modelli computazionali di cardiomiociti derivati da staminali umane per la valutazione del rischio proaritmico dei farmaci." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
Find full textCARE', SARA. "RICERCHE SU TALUNI INDICATORI DI TIPO BIOCHIMICO FISIOLOGICO ATTI A VALIDARE I MODELLI DI VALUTAZIONE DEL BENESSERE NEGLI ALLEVAMENTI DI BOVINE DA LATTE." Doctoral thesis, Università Cattolica del Sacro Cuore, 2010. http://hdl.handle.net/10280/782.
Full textThe objective assessment of lactating dairy cows welfare is complex and controversial. The main concerns are the choice of the model indicators and the aggregation of obtained results in a global score that represents the effective welfare. According to these considerations, the animal welfare determination needs a scientific validation. Our results shows that the value of fructosamine between the third and fifth week in lactation strongly reflects the average blood glucose in the previous weeks, therefore it shows the energetic deficit and the low nutritional status. The determination of chronic stress is also fundamental to determine the animal welfare, it can be measured by the plasmatic cortisolemic value. Some indicators of inflammators-infective stress, such as the positive proteins of acute phase (aptoglobins and ceruloplasmin) and the negative ones (albumins and cholesterol) are some of the best physiological indicators capable of validating the determination of animal welfare. On the contrary, the contemporary utilisation of different biochemical-physiological indicators could give more comprehensive determination of animal welfare. The latter could be used as “absolute” indicators to obtain more objective indications of the real conditions of breeding animals' welfare, therefore, being a valid “reference” for field models. These kind of analysis can give useful theorical indication to validate the welfare (above all considering the global view of it), and also in practical applications capable of defining the relative scores aggregating several aspects of welfare in field models. Also cortisol and fructosamine are very important physiological indicators. Particularly, the results obtained by this multivariate approach, which was applied to biochemical and physiological parameters, showed partial agreement between the welfare evaluation by SDIB model.
CARE', SARA. "RICERCHE SU TALUNI INDICATORI DI TIPO BIOCHIMICO FISIOLOGICO ATTI A VALIDARE I MODELLI DI VALUTAZIONE DEL BENESSERE NEGLI ALLEVAMENTI DI BOVINE DA LATTE." Doctoral thesis, Università Cattolica del Sacro Cuore, 2010. http://hdl.handle.net/10280/782.
Full textThe objective assessment of lactating dairy cows welfare is complex and controversial. The main concerns are the choice of the model indicators and the aggregation of obtained results in a global score that represents the effective welfare. According to these considerations, the animal welfare determination needs a scientific validation. Our results shows that the value of fructosamine between the third and fifth week in lactation strongly reflects the average blood glucose in the previous weeks, therefore it shows the energetic deficit and the low nutritional status. The determination of chronic stress is also fundamental to determine the animal welfare, it can be measured by the plasmatic cortisolemic value. Some indicators of inflammators-infective stress, such as the positive proteins of acute phase (aptoglobins and ceruloplasmin) and the negative ones (albumins and cholesterol) are some of the best physiological indicators capable of validating the determination of animal welfare. On the contrary, the contemporary utilisation of different biochemical-physiological indicators could give more comprehensive determination of animal welfare. The latter could be used as “absolute” indicators to obtain more objective indications of the real conditions of breeding animals' welfare, therefore, being a valid “reference” for field models. These kind of analysis can give useful theorical indication to validate the welfare (above all considering the global view of it), and also in practical applications capable of defining the relative scores aggregating several aspects of welfare in field models. Also cortisol and fructosamine are very important physiological indicators. Particularly, the results obtained by this multivariate approach, which was applied to biochemical and physiological parameters, showed partial agreement between the welfare evaluation by SDIB model.
Rago, Giovanni. "Valutazione dello stato di degrado e della vita di servizio di un viadotto lungo la linea ad alta velocità Firenze Roma." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
Find full textBonezzi, Riccardo. "Valutazione della vulnerabilità sismica e progetto di miglioramento degli edifici storici: modelli a confronto per il Palazzo Comunale di Mirandola." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textTorrisi, Antonio Maria. "Studi geologici di dettaglio per la definizione di modelli bidimensionali per la valutazione della risposta sismica locale in terreni vulcanici." Doctoral thesis, Università di Catania, 2016. http://hdl.handle.net/10761/4075.
Full textRemigi, Francesca. "Analisi e Ottimizzazione di Metodi e Modelli per la valutazione della propagazione sonora in campo libero." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427504.
Full textI modelli previsionali per la modellizzazione acustica vengono utilizzati per: determinare il contributo delle singole sorgenti sonore in un’area oggetto di indagine, prevedere il rumore immesso nell’ambiente da un’opera di nuova realizzazione, determinare/confrontare l’efficacia di eventuali interventi di mitigazione acustica. Tramite il modello numerico è possibile rappresentare la configurazione ambientale mediante: l’ individuazione delle sorgenti sonore significative, la caratterizzazione delle sorgenti (modelli di generazione), lo studio della propagazione tra la sorgente e il ricettore (modelli di propagazione).Di fondamentale importanza risulta essere la descrizione topografica del territorio (orografia ricettori). I metodi numerici effettuano simulazioni sulla base di formule analitiche che descrivono i fenomeni fisici legati alla propagazione partendo dai dati di potenza acustica delle sorgenti. In questa tesi si descrivono le difficoltà incontrate nella caratterizzazione delle sorgenti sonore (infrastrutture stradali, ferroviarie e sorgenti industriali), i limiti della normativa, l’incidenza delle condizioni meteorologiche, la correlazione tra misure conoscitive effettuate nel territorio e i valori di restituzione dei modelli.
Pappalardo, Maria Manuela. "Sistemi e misure di protezione internazionale dello straniero tra ordinamento italiano ed europeo, indagine sui modelli di valutazione del grado di personalizzazione del rischio." Doctoral thesis, Università di Catania, 2019. http://hdl.handle.net/10761/4097.
Full textD'AURIZIO, GIULIA. "Modelli di Task Switching nella valutazione della funzionalità esecutiva. Studi sperimentali condotti sulla popolazione generale e in individui con Malattia di Huntington." Doctoral thesis, Università degli Studi dell'Aquila, 2021. http://hdl.handle.net/11697/169733.
Full textMontanaro, Elsa. "Modelli e applicazioni per la valutazione della complessità dei progetti. Il caso Crif spa." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/12970/.
Full textRusca, Giulia <1993>. "Bellezza sostenibile: la cosmesi si fa bio. Modelli a scelta discreta per la valutazione delle preferenze di acquisto." Master's Degree Thesis, Università Ca' Foscari Venezia, 2018. http://hdl.handle.net/10579/13674.
Full textBernardini, Giulia. "Analisi e valutazione delle emissioni di un impianto di stoccaggio di gas naturale interrato e del loro impatto sulla qualità dell’aria." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textTarantino, Maria Nastasia. "Valutazione degli effetti delle emissioni in atmosfera di uno stabilimento agroindustriale mediante software CALPUFF." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Find full textVACCARI, LORENZO. "Studio dell'affidabilità di modelli farmacocinetici a base fisiologica nella valutazione dell'esposizione umana. Un caso di studio sulla contaminazione di acqua potabile da parte di sostanze perfluoroalchiliche nel nord Italia." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2021. http://hdl.handle.net/11380/1245532.
Full textA wide area in the Veneto region has been facing a perfluoroalkyl substances (PFAS) contamination which occurred mainly in groundwater and drinking water. Exposure of the population likely started in the Sixties and decreased after filter installations in 2013. The Veneto Region is conducting a biomonitoring study to investigate health conditions of the exposed population, collecting thousands of serum samples. Some Physiologically based Pharmacokinetic (PBPK) models are being tested comparing PFOA and PFOS measured levels with the estimated ones in order to find the model that best fits the available data.
Ferilli, Lorenzo. "Modelli ad elementi finiti personalizzati da dati TAC per la valutazione del rischio di frattura del collo del femore." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19039/.
Full textIezzi, Elisa <1982>. "Valutazione degli incentivi nel sistema delle cure primarie: analisi multilivello attraverso modelli logistici e panel con dati di conteggio." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2604/1/iezzi_elisa_tesi.pdf.
Full textIezzi, Elisa <1982>. "Valutazione degli incentivi nel sistema delle cure primarie: analisi multilivello attraverso modelli logistici e panel con dati di conteggio." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2604/.
Full textDe, Chiusole Debora. "Sviluppo e Applicazioni di Modelli Formali per la Valutazione Adattiva della Conoscenza e dell'Apprendimento nell'Ambito della Knowledge Space Theory." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424002.
Full textLe cinque ricerche che si presentano in questa tesi si sviluppano entro la knowledge space theory, una teoria matematica recente che fornisce un importante quadro di riferimento formale per lo sviluppo di sistemi computerizzati web-based che abbiano l'obiettivo di valutare la conoscenza e l'apprendimento degli individui. La nozione al centro dell'intera teoria è quella di di conoscenza, cioè l'insieme dei problemi che uno studente è capace di risolvere, in un certo dominio di conoscenza. La collezione di tutti gli stati di conoscenza osservabili in una popolazione di studenti costituisce una struttura di conoscenza. Le strutture di conoscenza sono un modello deterministico teorico dell'organizzazione della conoscenza all'interno di un particolare dominio. La loro validazione empirica è resa possibile grazie alla verifica probabilistica della loro plausibilità. Il basic local independence model (BLIM) è un modello probabilistico che è stato sviluppato a questo scopo. Nonostante sia il modello più utilizzato nella KST, problemi relativi alla sua applicabilità rimanevano ancora aperti. L'obiettivo generale delle prime tre ricerche che si presentano in questa tesi, è stato quello di risolvere questi problemi per conferire una maggiore validità alle applicazioni empiriche del modello. Nella KST, la nozione di stato di conoscenza non fornisce alcun tipo di interpretazione cognitiva. Invece, nella competence-based KST (CbKST) l'obiettivo principale della valutazione diviene quello individuare lo stato di competenza dello studente, ovvero l'insieme delle abilità che possiede. Le altre due ricerche che si presentano nella tesi si collocano all'interno di questo quadro teorico. Esse hanno avuto l'obiettivo di colmare alcune mancanze relative della CbKST, una di tipo probabilistico e l'altra di tipo deterministico.
CARUSO, DONATELLO. "Modelli di valutazione delle politiche di sviluppo rurale, il ruolo del capitale privato nella loro distribuzione: il caso della Misura 121 del PSR Puglia." Doctoral thesis, Università di Foggia, 2016. http://hdl.handle.net/11369/338822.
Full textVandi, Matteo. "Valutazione della sicurezza e progettazione di interventi di adeguamento statico e funzionale del cavalcaferrovia di Strada dell’Alpo a Verona." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textLapomarda, Michele. "Valutazione delle dinamiche di piena dell'asta medio-inferiore del fiume Po alla luce delle recenti indagini topografiche." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full text