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1

Kohler, Amber D., Melanie Donnelly, Blaire Balstad, et al. "60 Safety of Maintaining Nutrition Through Moderate Sedation for Burn Wound Care." Journal of Burn Care & Research 45, Supplement_1 (2024): 46. http://dx.doi.org/10.1093/jbcr/irae036.052.

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Abstract Introduction Physiologic changes in burn patients create a hypermetabolic state increasing nutrition requirements. The American Society of Anesthesiology recommends patients be made NPO with enough time to allow for gastric emptying prior to procedural sedation. Daily burn wound care needs requiring sedation make this approach untenable. We aimed to assess the risk of moderate sedation in those without interrupted nutrition. Methods A 12-month single centered retrospective analysis at our ABA verified center was performed. Burn patients with natural airways (non-intubated/non-trached)
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Eldawlatly, AbdelazeemA. "Moderate sedation: Introducing the "modified sedation continuum" and the "moderate sedation ladder"." Saudi Journal of Anaesthesia 8, no. 4 (2014): 449. http://dx.doi.org/10.4103/1658-354x.140815.

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3

Habighorst, Laura. "Procedural Sedation: Moderate Deep Sedation Medications." Pain Management Nursing 23, no. 2 (2022): 238. http://dx.doi.org/10.1016/j.pmn.2022.02.018.

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4

Haberland, Christel M., Suher Baker, and Haibei Liu. "Bispectral Index Monitoring of Sedation Depth in Pediatric Dental Patients." Anesthesia Progress 58, no. 2 (2011): 66–72. http://dx.doi.org/10.2344/0003-3006-58.2.66.

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Abstract The bispectral index (BIS) monitor records electroencephalogram waveforms and provides an objective measure of the hypnotic effect of a sedative drug on brain activity. The aim of this pilot study was to use the BIS monitor to evaluate the depth of procedural sedation in pediatric dental patients and to assess if the BIS monitor readings correlate with a validated pediatric sedation scale, the University of Michigan Sedation Scale (UMSS), in determining the level of sedation in these patients. Thirty-five pediatric dental patients requiring sedation were studied prospectively. A basel
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5

Becker, Daniel E. "Pharmacokinetic Considerations for Moderate and Deep Sedation." Anesthesia Progress 58, no. 4 (2011): 166–73. http://dx.doi.org/10.2344/0003-3006-58.4.166.

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Abstract Moderate and deep sedation can be provided using several routes of drug administration including oral (PO), inhalation, and parental injection. The safety and efficacy of these various techniques is largely dependent on pharmacokinetic principles. This continuing education article will highlight essential principles of absorption, distribution, and elimination of commonly used sedative agents.
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6

Kyle, Erin. "Moderate Sedation and Analgesia." AORN Journal 118, no. 3 (2023): 183–89. http://dx.doi.org/10.1002/aorn.13991.

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7

Yen, Philip, Simon Prior, Cara Riley, William Johnston, Megann Smiley, and Sarat Thikkurissy. "A Comparison of Fospropofol to Midazolam for Moderate Sedation During Outpatient Dental Procedures." Anesthesia Progress 60, no. 4 (2013): 162–77. http://dx.doi.org/10.2344/0003-3006-60.4.162.

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Abstract Moderate intravenous (IV) sedation combined with local anesthesia is common for outpatient oral surgery procedures. An ideal sedative agent must be safe and well tolerated by patients and practitioners. This study evaluated fospropofol, a relatively new sedative/hypnotic, in comparison to midazolam, a commonly used benzodiazepine, for IV moderate sedation during oral and maxillofacial surgery. Sixty patients were randomly assigned to either the fospropofol or the midazolam group. Each participant received 1 μg/kg of fentanyl prior to administration of the selected sedative. Those in t
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Ebert, Thomas J. "Sympathetic and Hemodynamic Effects of Moderate and Deep Sedation with Propofol in Humans." Anesthesiology 103, no. 1 (2005): 20–24. http://dx.doi.org/10.1097/00000542-200507000-00007.

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Background The objective of this study was to determine the mechanisms involved in the hypotension associated with sedative doses of propofol in humans. Methods Ten healthy volunteers (aged 21-37 yr) participated on two occasions and in random order received placebo or propofol infusions. Standard monitoring and radial artery blood pressure were combined with measurement of forearm blood flow (plethysmography) and derivation of forearm vascular resistance, recording of peroneal nerve sympathetic activity, and blood sampling for norepinephrine concentrations. A computer-controlled infusion pump
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Flinspach, Armin Niklas, Sebastian Zinn, Kai Zacharowski, Ümniye Balaban, Eva Herrmann, and Elisabeth Hannah Adam. "Electroencephalogram-Based Evaluation of Impaired Sedation in Patients with Moderate to Severe COVID-19 ARDS." Journal of Clinical Medicine 11, no. 12 (2022): 3494. http://dx.doi.org/10.3390/jcm11123494.

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The sedation management of patients with severe COVID-19 is challenging. Processed electroencephalography (pEEG) has already been used for sedation management before COVID-19 in critical care, but its applicability in COVID-19 has not yet been investigated. We performed this prospective observational study to evaluate whether the patient sedation index (PSI) obtained via pEEG may adequately reflect sedation in ventilated COVID-19 patients. Statistical analysis was performed by linear regression analysis with mixed effects. We included data from 49 consecutive patients. None of the patients rec
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10

Lee, Oh Haeng. "Updated sedative basics guide: everything you need to know about sedatives in clinical practice." Journal of the Korean Medical Association 67, no. 4 (2024): 285–95. http://dx.doi.org/10.5124/jkma.2024.67.4.285.

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Background: As interventional procedures become more common in clinical practice, sedatives are being increasingly used to enhance patient experience, overall safety, and procedural efficacy. An appropriate sedation depth, which is crucial for patient safety, is determined according to sedative dosage, procedural stimuli, and patient status. Thus, it is important that clinicians understand the continuous nature of sedation levels.Current Concepts: Although sedation offers benefits, it also carries risks. Thus, vigilant monitoring during and after a procedure is important for preventing excessi
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11

Eslinger, M. Ron. "Moderate Sedation for Nonanesthesia Nurses." Gastroenterology Nursing 31, no. 2 (2008): 163. http://dx.doi.org/10.1097/01.sga.0000316571.31298.d6.

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12

Nuccio, Susan. "The Challenges of Moderate Sedation." Gastroenterology Nursing 31, no. 2 (2008): 170. http://dx.doi.org/10.1097/01.sga.0000316609.06641.28.

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13

Roddy, Sean P. "Moderate sedation billing in 2017." Journal of Vascular Surgery 65, no. 3 (2017): 921–22. http://dx.doi.org/10.1016/j.jvs.2017.01.019.

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14

Cohen, Norman A., and Stanley W. Stead. "Moderate Sedation for Chest Physicians." Chest 133, no. 6 (2008): 1489–94. http://dx.doi.org/10.1378/chest.07-2150.

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15

Villegas, Terry. "Sleep Apnea and Moderate Sedation." Gastroenterology Nursing 27, no. 3 (2004): 121–24. http://dx.doi.org/10.1097/00001610-200405000-00006.

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16

Fencl, Jennifer L. "Guideline Implementation: Moderate Sedation/Analgesia." AORN Journal 103, no. 5 (2016): 500–511. http://dx.doi.org/10.1016/j.aorn.2016.03.001.

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17

Dossa, Fahima, Catherine Dubé, Jill Tinmouth, et al. "Practice recommendations for the use of sedation in routine hospital-based colonoscopy." BMJ Open Gastroenterology 7, no. 1 (2020): e000348. http://dx.doi.org/10.1136/bmjgast-2019-000348.

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ObjectiveAlthough sedation improves patient experience during colonoscopy, there is great jurisdictional variability in sedative practices. The objective of this study was to develop practice recommendations for the use of moderate and deep sedation in routine hospital-based colonoscopy to facilitate standardisation of practice.DesignWe recruited 32 multidisciplinary panellists to participate in a modified Delphi process to establish consensus-based recommendations for the use of sedation in colonoscopy. Panel members participated in a values assessment survey followed by two rounds of anonymo
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18

Sue-Chue-Lam, Colin, Matthew Castelo, Jill Tinmouth, Diego Llovet, Teruko Kishibe, and Nancy N. Baxter. "Non-pharmacological interventions to improve the patient experience of colonoscopy under moderate or no sedation: a systematic review protocol." BMJ Open 10, no. 9 (2020): e038621. http://dx.doi.org/10.1136/bmjopen-2020-038621.

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IntroductionThe patient experience is a critical dimension of colonoscopy quality. Sedative and analgesic drugs are commonly used to improve the patient experience of colonoscopy, with predominant regimens being deep sedation, typically achieved with propofol, and moderate sedation, typically achieved with an opioid and a benzodiazepine. However, non-pharmacological interventions exist that may be used to improve patient experience. Furthermore, by identifying non-pharmacological interventions to increase the quality of patient experience under moderate sedation, jurisdictions facing rising us
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19

Garg, Shashank, Shorabuddin Syed, Abhilash Perisetti, Sumant Inamdar, and John Vargo. "Patient characteristics and procedural outcomes of moderate sedation for endoscopic procedures in patients with obesity: A retrospective, propensity score-matched study." Endoscopy International Open 09, no. 11 (2021): E1674—E1679. http://dx.doi.org/10.1055/a-1555-2762.

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Abstract Background Endoscopic procedures are performed commonly with moderate sedation. Obesity can pose a challenge in its safe administration. This study was aimed at assessing outcomes of endoscopy procedures performed with moderate sedation in obese patients. Patients and methods This was a retrospective study of patients undergoing esophagogastroduodenoscopy (EGD) and/or colonoscopy with moderate sedation from July 17, 2017 to December 31, 2019. Demographics, comorbidities, outpatient medications and procedure-related outcomes (procedure time, recovery time, cardiopulmonary adverse event
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20

Koers, Lena, Suzanne Eberl, Anne Cappon, et al. "Safety of moderate-to-deep sedation performed by sedation practitioners." European Journal of Anaesthesiology 35, no. 9 (2018): 659–66. http://dx.doi.org/10.1097/eja.0000000000000835.

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21

Lien, C. A. "Comparison of Propofol Deep Sedation Versus Moderate Sedation During Endosonography." Yearbook of Anesthesiology and Pain Management 2011 (January 2011): 385–86. http://dx.doi.org/10.1016/j.yane.2011.02.003.

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22

Nayar, D. S., W. G. Guthrie, A. Goodman, et al. "Comparison of Propofol Deep Sedation Versus Moderate Sedation During Endosonography." Digestive Diseases and Sciences 55, no. 9 (2010): 2537–44. http://dx.doi.org/10.1007/s10620-010-1308-0.

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23

Khandelwal, Anjay, Jeffrey D. Solomon, Beverly Beaucock, and Richard B. Lou. "116 Clinical Impact of Transitioning from a Burn Provider-based to Hospitalist-based Sedation Service." Journal of Burn Care & Research 43, Supplement_1 (2022): S75. http://dx.doi.org/10.1093/jbcr/irac012.118.

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Abstract Introduction Burn patients often experience a tremendous amount of pain and anxiety during dressing changes and other procedures, frequently requiring a moderate sedation (MS) or deep sedation (DS) for successful completion. We previously reported our primarily Nurse Practitioner-based model for procedural sedation but recently transitioned to a primarily hospitalist-based sedation service. We evaluated the clinical and financial impact of this transition. Methods Retrospective chart review of patients undergoing MS or DS from June 2019 to June 2020 (burn provider-based [BPB]) and Aug
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24

Lim, Tae Wan, Yi Hwa Choi, Jong Yeop Kim, et al. "Efficacy of the bispectral index and Observer’s Assessment of Alertness/Sedation Scale in monitoring sedation during spinal anesthesia: A randomized clinical trial." Journal of International Medical Research 48, no. 4 (2019): 030006051989316. http://dx.doi.org/10.1177/0300060519893165.

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Objective The bispectral index (BIS) has been used to monitor sedation during spinal anesthesia. We evaluated the correlation between BIS and the Observer’s Assessment of Alertness/Sedation Scale (OAA/S) in patients sedated with dexmedetomidine, propofol, or midazolam. Methods This prospective, randomized study included 46 patients scheduled for knee arthroplasty under spinal anesthesia with sedation. The patients were randomized to receive sedation with dexmedetomidine (n = 15), propofol (n = 15), or midazolam (n = 16). Correlation between BIS and OAA/S was assessed during sedation in the thr
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25

Andrews, Regina W. "Moderate Sedation/Analgesia: Competency Assessment Module." AORN Journal 77, no. 2 (2003): 470. http://dx.doi.org/10.1016/s0001-2092(06)61217-9.

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26

Roach, Carol Lafayette, Nazia Husain, Jennifer Zabinsky, Elizabeth Welch, and Ruchira Garg. "Moderate Sedation for Echocardiography of Preschoolers." Pediatric Cardiology 31, no. 4 (2010): 469–73. http://dx.doi.org/10.1007/s00246-009-9622-z.

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27

Mahoney, Greg. "Moderate Sedation in Paediatric Dental Patients." Australian Dental Journal 57, no. 4 (2012): 522–23. http://dx.doi.org/10.1111/adj.12012.

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28

Becker, Daniel E. "Pharmacodynamic Considerations for Moderate and Deep Sedation." Anesthesia Progress 59, no. 1 (2012): 28–42. http://dx.doi.org/10.2344/0003-3006-59.1.28.

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Moderate and deep sedation can be provided using various classes of drugs, each having unique mechanisms of action. While drugs within a given classification share similar mechanisms and effects, certain classes demonstrate superior efficacy but added concern regarding safety. This continuing education article will highlight essential principles of pharmacodynamics and apply these to drugs commonly used to produce moderate and deep sedation.
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29

REX, D. K. "Review article: moderate sedation for endoscopy: sedation regimens for non-anaesthesiologists." Alimentary Pharmacology and Therapeutics 24, no. 2 (2006): 163–71. http://dx.doi.org/10.1111/j.1365-2036.2006.02986.x.

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30

Chittle, Melissa D., Erin McIntyre, Judy Borsody Lotti, et al. "Utilizing a Sedation Decision Aid in Ambulatory Venous Access Device Placement: Effects on Patient Choice, Workup, and Recovery Time." Journal of the Association for Vascular Access 23, no. 2 (2018): 79–85. http://dx.doi.org/10.1016/j.java.2018.03.001.

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Abstract This study was undertaken to determine the influence of using a sedation decision aid when selecting a sedation option for totally implantable vascular access device placement on patient choice, workup, and recovery time. An institutional review board-approved, Health Insurance Portability and Accountability Act-compliant, retrospective study of 76 patients (aged 23–89 years, 58% female) presenting to a vascular interventional radiology department between January 2, 2017, and May 5, 2017. Patients were given a decision aid that inquired about personal values and goals, and provided in
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31

Gentz, Rachel, Paul Casamassimo, Homa Amini, Dan Claman, and Megann Smiley. "Safety and Efficacy of 3 Pediatric Midazolam Moderate Sedation Regimens." Anesthesia Progress 64, no. 2 (2017): 66–72. http://dx.doi.org/10.2344/anpr-64-02-04.

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Our aim was to characterize effectiveness and complications in children receiving oral midazolam alone, nasal midazolam alone, or oral midazolam with other sedatives. Children received oral midazolam alone, nasal midazolam, or oral midazolam in combination with other sedative medications. All subjects received a presedation history and physical examination and were sedated per protocol by any of 28 resident providers under attending supervision. Sedations were rated for success and complications by clinicians. Postoperative complications were assessed by trained staff up to 48 hours postoperat
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32

Kinard, Bryce W., Andrew S. Zale, and Kenneth L. Reed. "Efficacy of Midazolam/Meperidine vs Midazolam/Hydromorphone for Enteral Moderate Sedation in the Pediatric Dental Patient." Anesthesia Progress 71, no. 1 (2024): 15–18. http://dx.doi.org/10.2344/22-00037.

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Objective: The goal of this study was to compare the efficacy of midazolam/meperidine (M/M) vs midazolam/hydromorphone (M/H) for enteral moderate sedation along with inhalational sedation in pediatric dental patients. Methods: This retrospective chart review analyzed the charts of pediatric patients who received dental treatment under enteral moderate sedation with either M/M or M/H in combination with inhalational sedation (nitrous oxide/oxygen) at El Rio Community Health Centers (affiliated with NYU Langone) in Tucson, Arizona, from July 2014 to December 2020. Included subjects were between
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Barr, Juliana, Katayoun Zomorodi, Edward J. Bertaccini, Steven L. Shafer, and Eran Geller. "A Double-blind, Randomized Comparison of IV Lorazepam versus Midazolam for Sedation of ICU Patients via a Pharmacologic Model." Anesthesiology 95, no. 2 (2001): 286–98. http://dx.doi.org/10.1097/00000542-200108000-00007.

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Background Benzodiazepines, such as lorazepam and midazolam, are frequently administered to surgical intensive care unit (ICU) patients for postoperative sedation. To date, the pharmacology of lorazepam in critically ill patients has not been described. The aim of the current study was to characterize and compare the pharmacokinetics and pharmacodynamics of lorazepam and midazolam administered as continuous intravenous infusions for postoperative sedation of surgical ICU patients. Methods With Institutional Review Board approval, 24 consenting adult surgical patients were given either lorazepa
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34

Lim, Valencia, Reon Yew Zhou Chin, Adrian Kee, Jeffrey Ng, and Kay Choong See. "Diagnostic Yield and Safety of CP-EBUS-TBNA and RP-EBUS-TBLB under Moderate Sedation: A Single-Center Retrospective Audit." Diagnostics 12, no. 11 (2022): 2576. http://dx.doi.org/10.3390/diagnostics12112576.

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Convex probe endobronchial ultrasound transbronchial needle aspirations (CP-EBUS-TBNAs) and radial probe endobronchial ultrasound transbronchial lung biopsies (RP-EBUS-TBLBs) can be performed under moderate sedation or general anesthesia. Moderate sedation is more convenient, however patient discomfort may result in inadequate tissue sampling. General anesthesia ensures better patient cooperation but requires more logistics and also carries sedation risks. We aim to describe the diagnostic yield and safety of CP-EBUS-TBNAs and RP-EBUS-TBLBs when performed under moderate sedation at our center.
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35

Karm, Myong-Hwan. "Clinical practice guidelines for diagnostic and procedural sedation." Journal of The Korean Dental Association 61, no. 4 (2023): 298–306. http://dx.doi.org/10.22974/jkda.2023.61.4.004.

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The American Dental Association states that the administration of local anesthesia, sedation and generalanesthesia is an integral part of dental practice. It is significant that the American Dental Association definessedation as well as local anesthesia as an integral part of dental practice. A new sedation guideline was published in Korea in 2022. This guideline has been published to help both anesthesiologists and non-anesthesiologists provide safe and effective moderate sedation to patients consistently, without limitation, at any medical institu-tion. This guideline was developed with a fo
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36

Olsen, Jonathan W., Richard L. Barger, and Shashin K. Doshi. "Moderate Sedation: What Radiologists Need to Know." American Journal of Roentgenology 201, no. 5 (2013): 941–46. http://dx.doi.org/10.2214/ajr.12.9501.

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37

Williams, Katherine. "Guidelines in Practice: Moderate Sedation and Analgesia." AORN Journal 115, no. 6 (2022): 553–64. http://dx.doi.org/10.1002/aorn.13690.

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38

Kummer, Deborah Jo, and Bonnie J. Walden. "Capnography Monitoring for Patients Undergoing Moderate Sedation." Gastroenterology Nursing 42, no. 1 (2019): 49–54. http://dx.doi.org/10.1097/sga.0000000000000426.

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39

Tobin, Catherine D., Carlee A. Clark, Matthew D. McEvoy, et al. "An Approach to Moderate Sedation Simulation Training." Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare 8, no. 2 (2013): 114–23. http://dx.doi.org/10.1097/sih.0b013e3182786209.

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40

Goyal, Rakhee. "Moderate and Deep Sedation in Clinical Practice." Anesthesia & Analgesia 127, no. 4 (2018): e61. http://dx.doi.org/10.1213/ane.0000000000003639.

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Moloney-Harmon, Patricia A. "Lights out Pediatric moderate sedation and analgesia." OR Nurse 4, no. 6 (2010): 32–38. http://dx.doi.org/10.1097/01.orn.0000388941.60223.67.

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&NA;. "Lights out Pediatric moderate sedation and analgesia." OR Nurse 4, no. 6 (2010): 38–39. http://dx.doi.org/10.1097/01.orn.0000390692.75346.05.

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Conlon, Patricia, Debra Rowekamp, and Amy Chihak. "Simulation Enhances a Pediatric Moderate Sedation Curriculum." Journal of Pediatric Nursing 26, no. 4 (2011): e23. http://dx.doi.org/10.1016/j.pedn.2011.01.270.

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Levine, Adam I., Shefali Sanyal, Andrew E. Dikman, James Aisenberg, Kenneth M. Miller, and Lawrence B. Cohen. "Moderate Sedation Training Using High-Fidelity Simulation." Gastrointestinal Endoscopy 67, no. 5 (2008): AB301. http://dx.doi.org/10.1016/j.gie.2008.03.881.

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&NA;. "CE Test: Sleep Apnea and Moderate Sedation." Gastroenterology Nursing 27, no. 3 (2004): 124–25. http://dx.doi.org/10.1097/00001610-200405000-00007.

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Nuccio, Susan A. "Moderate (Conscious) Sedation Update, Challenges, and Issues." Gastroenterology Nursing 28, no. 2 (2005): 173. http://dx.doi.org/10.1097/00001610-200503000-00069.

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Cohen, Lawrence B., Jackie Kline, Chao Wang, and James B. Jones. "AQUAVAN® for Moderate Sedation during Colonoscopy." American Journal of Gastroenterology 101 (September 2006): S515. http://dx.doi.org/10.14309/00000434-200609001-01343.

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48

Nelson, Michael E. "Moderate Sedation Changes for Bronchoscopy in 2017." Chest 152, no. 4 (2017): 893–97. http://dx.doi.org/10.1016/j.chest.2017.06.027.

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49

Stein, Patricia. "Managing The Patient Receiving Moderate Sedation/Analgesia." AORN Journal 92, no. 4 (2010): 485–87. http://dx.doi.org/10.1016/j.aorn.2010.07.004.

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Metzner, Julia, and Karen B. Domino. "Moderate Sedation: A Primer for Perioperative Nurses." AORN Journal 102, no. 5 (2015): 526–35. http://dx.doi.org/10.1016/j.aorn.2015.09.001.

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