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Journal articles on the topic 'Modern antihypertensives drugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Podzolkov, V. I., A. I. Tarzimanova, and Z. O. Georgadze. "Modern Principles of Treatment of Uncontrolled Hypertension." Rational Pharmacotherapy in Cardiology 15, no. 5 (2019): 736–41. http://dx.doi.org/10.20996/1819-6446-2019-15-5-736-741.

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Despite the current possibilities of using different classes of antihypertensive drugs that effectively reduce blood pressure and significantly improve the long-term prognosis of patients, the problem of uncontrolled arterial hypertension has not lost its importance and its solution in a particular clinical situation often remains very difficult. The term "uncontrolled arterial hypertension" can be used in all cases where arterial pressure has not been achieved. The true prevalence of uncontrolled arterial hypertension has not been established, and its study is hampered primarily by the fact t

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Morozova, T. E. "Combined antihypertensive therapy in the light of modern recommendations: strategy of one tablet." Systemic Hypertension 15, no. 4 (2018): 92–96. http://dx.doi.org/10.26442/2075082x.2018.4.180110.

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The review focuses on the main strategies of antihypertensive therapy set out in the 2018 ESC/ESH recommendations. The basis of antihypertensive therapy consists of five main classes of antihypertensive drugs, which should form the basis of the combined drug antihypertensive therapy in most patients. The single pill strategy is to take advantage of fixed combinations as a starting antihypertensive therapy for most patients. Among the fixed combinations, the combination of an ACE inhibitor with a diuretic (Noliprel®) remains one of the most preferred for antihypertensive therapy, since In addit

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Sayutina, E. V. "Fixed combinations in modern hypertension treatment algorithms." Cardiovascular Therapy and Prevention 17, no. 6 (2018): 86–94. http://dx.doi.org/10.15829/1728-8800-2018-6-86-94.

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Modern appropriate treatment of hypertension involves the use of combination antihypertensive therapy. According to updated version of European Society of Cardiology 2018 guidelines, renin-angiotensin-aldosterone system blockers must be used as first-line drugs, including in combination with hydrochlorothiazide. This article presents the algorithms for the management of patients with uncomplicated and asymptomatic (with target lesions) arterial hypertension. It also described the management of patients with concomitant cardiovascular, cerebrovascular, renal pathology and diabetes mellitus, and

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Soboleva, M. S., and E. E. Loskutova. "Analysis of acquisition and the monthly cost of antihypertensive therapy with modern fixed-dose combinations in the Far Eastern Federal District." FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Pharmacoepidemiology 14, no. 1 (2021): 41–49. http://dx.doi.org/10.17749/2070-4909/farmakoekonomika.2021.061.

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Objective: analyzing the acquisition and monthly costs for patients on modern fixed-dose antihypertensive combinations in three regions of the Far Eastern Federal District.Material and methods. Intra-group analysis of retail of antihypertensive drugs for 2019 in drugstores of the Khabarovsk Region, Sakhalin Region, Amur Region (n=100) was carried out. The calculation of the monthly cost of therapy was performed and total sales indicators were identified. Statistical analysis: dispersion analysis, Spearman's rank correlation coefficient, Kruskal–Wallis test.Results. The maximum demand in patien

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Pinchuk, Tatiana V., and Natalia V. Orlova. "The place of fixed antihypertensive drugs in modern therapy of arterial hypertension." Systemic Hypertension 17, no. 4 (2021): 44–48. http://dx.doi.org/10.26442/2075082x.2020.4.200035.

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The article provides information on modern approaches to the treatment of arterial hypertension. The historical information about therapy with combined antihypertensive drugs is given. Based on data from multicenter clinical trials, the article provides evidence of the benefits of dual and triple fixed drug combinations. Combinations of 1-adrenoreceptor antagonist bisoprolol and the dihydropyridine-type calcium channel blocker amlodipine are considered. The article highlights the advantages of each of the drugs, as well as their combination. It shows the benefits of a fixed combination of low

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Zhdan, V. М., V. G. Lebid, H. S. Кhaimenova, and G. A. Isheikina. "GOUT AND ARTERIAL HYPERTENSION: THERAPY PECULIARITIES." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 1 (2020): 100–105. http://dx.doi.org/10.31718/2077-1096.20.1.100.

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The article highlights the issues on comorbidity between gout and hypertension. Emphasis is placed on the necessity in searching for a well-balanced approach toward the treatment this type of comorbidity. Gout is a major social and economic problem in the modern society that leads to a progressive physical incapability, limitation of professional activity, thus impairing the quality of life. Arterial hypertension occurs in patients with gout in 5 - 50% of cases, and in combination with components of metabolic syndrome its prevalence rises up to 80%. As a result, the development of hypertension

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Temnikova, E. A. "A new fixed combination of perindopril, indapamide and amlodipine. "Three in one" is the way to improve the results of arterial hypertension treatment." Systemic Hypertension 14, no. 2 (2017): 65–68. http://dx.doi.org/10.26442/sg29195.

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The management of patients with arterial hypertension is a difficult problem even if use the modern antihypertensive drugs. The reasons of the inadequate control to arterial pressure level during the treatment are different. The application fixed combinations of antihypertensive drugs improves the results of therapy, weigh with separate pathogenetic mechanisms of blood pressure increasing and the counterregulatory effects of the treatment each components of the combination. The use of fixed combinations significantly increases patient adherence to treatment. A new fixed triple combination of p

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Shehyan, G. G., A. A. Yalymov, A. M. Schikota, V. S. Zadionchenko, and S. I. Varentsov. "The telmisartan and amlodipine combination in the treatment of hypertension." Systemic Hypertension 11, no. 1 (2014): 64–72. http://dx.doi.org/10.26442/sg29014.

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The following review assesses socially significant disease - hypertension (AH) - and the problem of finding an effective antihypertensive therapy. Twynsta® drug (manufacturer Boehringer Ingelheim Pharma) - modern combined antihypertensive drug, which not only provides effective blood pressure control, but also due to the protective effect has been proved for all target organs improves the life expectancy of patients with hypertension. The clinical studies show that combination of telmisartan and amlodipine provides additional benefits in the treatment of patients with metabolic syndrome (by im

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Lebedev, P. A., A. A. Garanin, and E. V. Paranina. "Evolution of antihypertensive combined therapy: from depressin of academician A. L. Myasnikov to modern multi-component drugs." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 27, no. 1 (2021): 73–82. http://dx.doi.org/10.18705/1607-419x-2021-27-1-73-82.

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The article shows the historical background to the emergence and subsequent development of combined antihypertensive therapy from creation of a multi-component drug to modern fixed combinations as the most effective approach in the treatment of hypertension (HTN). The authors consider that Russian scientist therapist academician of the USSR Academy of medical Sciences A. L. Myasnikov, has priority in the development of fixed drug combination concept, created depressin powder. The development of pharmacology as a science and the achievements in pharmaceutical technologies contributed to the exp

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Ostroumova, O. D., O. V. Bondarets, I. I. Kopchenov, and T. F. Guseva. "From the choice of antihypertensive drug to the choice of fixed combinations of antihypertensive drugs: a paradigm shift." Systemic Hypertension 12, no. 4 (2015): 23–29. http://dx.doi.org/10.26442/sg29109.

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The article considers modern approaches to treatment of arterial hypertension. Emphasizes the need for combination antihypertensive therapy, mainly fixed combinations of antihypertensive drugs, patients with high and very high risk already at the start of treatment. Discusses the advantages of combinations of blockers of receptors of angiotensin II to diuretics and calcium antagonists, as well as clinical situations in which these combinations are a priority. Considered the evidence base, pharmacokinetics and clinical benefit of the representative of a class of blockers of receptors for angiot

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Barbarash, O. L., and V. V. Kashtalap. "Modern possibilities of hypertension drug therapy. Candesartan and its place in the therapy." Systemic Hypertension 10, no. 4 (2013): 55–58. http://dx.doi.org/10.26442/sg28988.

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Arterial hypertension (AH) remains the one of the major cardiovascular diseases in the adult population and a major factor in cardiovascular and cerebrovascular morbidity and mortality. Drug therapy of hypertension leads to a reduction of cardiovascular risk by affecting blood pressure. Renin-angiotensin-aldosterone system (RAAS) plays a key role in the formation of hypertension, as the drug blockade of its components can significantly improve the prognosis of patients. The principal means of blocking the RAAS are angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor antagoni

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Gilyarevsky, S. R. "The problem of determining the efficiency of treatmentin the era of evidence-based medicine: international and domestic experience." Systemic Hypertension 11, no. 2 (2014): 67–71. http://dx.doi.org/10.26442/sg29033.

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This article deals with the modern approach to the choice of effective drugs, such as angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, in preventing cardiovascular complications. We discuss evidential considerations of the drugs administration and the detection principles, concerning effective therapy in special clinical situations. The present paper deals with the results not only of the randomized trials but with the results from recent observational studies being reflective of real practice in the application of antihypertensive drug.

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Ostroumova, O. D., and A. I. Kochetkov. "Current Trends in the Treatment of Hypertension: Focus on Improving Prognosis. The Capabilities of an Amlodipine/Telmisartan Single-Pill Combination." Rational Pharmacotherapy in Cardiology 15, no. 6 (2020): 906–17. http://dx.doi.org/10.20996/1819-6446-2019-15-6-906-917.

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Nowadays, the modern approach to antihypertensive therapy is to prescribe in the most hypertensive patients fixed-dose combinations of antihypertensive drugs as initial therapy. This concept is reflected in the latest revisions of European and Russian guidelines for the management of arterial hypertension (AH). Above mentioned principle is referred as “single-pill combination” strategy and is given high priority in clinical practice with a high evidence level. According to this approach, one of the possible first line single-pill combinations is the combination of an angiotensin II receptor bl

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Domoratskyi, O. E. "Emergency care for hypertensive crises: how to save a patient? Review of modern recommendations." Infusion & Chemotherapy, no. 3.2 (December 15, 2020): 87–88. http://dx.doi.org/10.32902/2663-0338-2020-3.2-87-88.

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Background. Arterial hypertension (AH) is a risk factor for stroke and myocardial infarction. In low-income countries, the prevalence of hypertension is 42 %. Hypertensive crisis (HC) is an acute increase in blood pressure – BP (systolic BP >200 mm Hg, diastolic BP >120 mm Hg), which is accompanied by the threat or progression of target organs damage and requires the immediate controlled reduction of BP. Objective. To describe the emergency care for HC. Materials and methods. Analysis of current recommendations and literature data. Results and discussion. HC are classif

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Gilyarevsky, S. R., M. V. Golshmid, N. G. Bendeliani, I. M. Kuzmina, G. Y. Zaharova, and I. I. Sinitcina. "Vascular age concept: role in assessing risk and choosing therapy." Medical Council, no. 21 (January 28, 2020): 51–57. http://dx.doi.org/10.21518/2079-701x-2019-21-51-57.

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The article discusses the vascular age concept and modern approaches to assessing vascular age. It describes modern methods for measuring arterial stiffness (applanation tonometry or ultrasonic Doppler examination) as the most frequently used index of vascular age. The authors discuss the role of antihypertensive therapy and statins in preventing early vascular aging, and the relationship between the role of achieving lower blood pressure levels and the choice of certain antihypertensive agents to reduce arterial stiffness and ensure optimal vascular age. Increased arterial stiffness has been

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Bubnova, M. G. "Modern approaches to the treatment and long-term management of arterial hypertension in clinical practice. Pharmacological and clinical characteristics of angiotensin II receptor blockers: focus on azilsartan medoxomil. Part I." CardioSomatics 6, no. 2 (2015): 69–80. http://dx.doi.org/10.26442/cs45177.

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This article deals withthe overview of the pharmacological characteristics of one class of antihypertensive drugs - angiotensin II receptor antagonists (ARA II) and new member of this class - azilsartan medoxomil (Edarbi®).We have analyzed the antihypertensive efficacy of different ARA, as well as azilsartan medoxomil efficacyin case of monotherapy and in comparison with other ARA and angiotensin-converting enzyme inhibitorsamong different groups of patients.The article describes the pleiotropic effects of azilsartan medoxomil, discovered nowadays.

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Mudau, Gundo, Samuel Odeyemi, and John Dewar. "Vhavenda Herbal Remedies as Sources of Antihypertensive Drugs: Ethnobotanical and Ethnopharmacological Studies." Oxidative Medicine and Cellular Longevity 2020 (December 11, 2020): 1–18. http://dx.doi.org/10.1155/2020/6636766.

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Hypertension is a dominant risk factor for the development of cardiovascular, kidney, and eye diseases. In Africa, it increasingly leads to hospitalisation and a strain on the public health system. However, rather than modern medicine, African traditional healers are the first choice for most South Africans. Therefore, this study is aimed at gathering information on herbal remedies traditionally used for the treatment of high blood pressure in Vhavenda, South Africa, and comparing this information with reports in the literature regarding plants used to manage high blood pressure. An ethnobotan

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Leonova, Marina V. "Modern strategy in the treatment of arterial hypertension: combination therapy and fixed combinations." Consilium Medicum 23, no. 6 (2021): 485–90. http://dx.doi.org/10.26442/20751753.2021.6.200942.

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The introduction of fixed combinations for the treatment of arterial hypertension (AH) is an effective strategy to address the public health burden of cardiovascular disease. This strategy is reflected in modern international guidelines for the treatment of AH and is supported by World Health Organization. The use of fixed combinations allows solving key practical problems to achieve better results and improve the prognosis of AH: ensuring the greatest decrease in blood pressure (BP) and a lower target BP level, shortening the time period for obtaining target BP, increasing adherence to treatm

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Odinak, M. M., G. G. Khubulava, A. N. Kuznetcov, I. A. Vosnyuk, and N. A. Arsenova. "Modern angiotensmconverting enzyme inhibitors m correction of cerebral haemodynamics in hypertension." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 12, no. 4 (2006): 347–50. http://dx.doi.org/10.18705/1607-419x-2006-12-4-347-350.

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The study addresses changes of cerebral circulation during perindopril therapy of hypertension. 33 hypertensive patients were included (males - 15 (45,5%); females - 18 (54,5%). 20 patients (60,6%) received perindopril e 4 mg per day, 13 patients of control group were treated by alternative antihypertensive drugs. Neurology status, cerebral circulation (Sonomed, Spectodem, Russia) were evaluated at baseline and after 6 months of treatment. Results obtained demonstrated that perindopril can improve cerebral circulation independently of blood pressure reduction and has angioprotective effect. In

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Rodionov, Anton V., Ivan G. Yudin, and Viktor V. Fomin. "Resistant arterial hypertension." Consilium Medicum 23, no. 1 (2021): 28–31. http://dx.doi.org/10.26442/20751753.2021.1.200697.

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The review provides modern data on the examination and treatment tactics of patients with resistant arterial hypertension (RAH). The prevalence of RAH is about 10–15%, with a significant proportion of pseudo-resistance cases associated with low adherence to therapy, inaccurate blood pressure measurement technique, and increased arterial stiffness in the elderly. In patients with RAH, it is necessary to exclude secondary hypertension, of which drug hypertension associated with the use of nonsteroidal anti-inflammatory drugs, nasal sympathomimetics, oral contraceptives, as well as those caused b

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Maksimov, M. L., and O. V. Dralova. "Angiotensin receptor blocker telmisartan: efficacy, safety and relevance of clinical application." Systemic Hypertension 14, no. 1 (2017): 51–57. http://dx.doi.org/10.26442/sg29177.

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Angiotensin receptor blocker telmisartan is a modern and effective antihypertensive drug which has advantages in comparison with other drugs of the group of angiotensin receptor blockers. Long half-life retains its effect is significant more than 24 hours, which is especially important for blood pressure control in the dangerous morning hours. Telmisartan is excreted by the kidneys less than 2%, making its use safe in patients with renal pathology. High antihypertensive efficacy combined with its excellent tolerability. Telmisartan has the greatest affinity to PPARg-receptors, which is especia

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Bubnova, Marina Gennad'evna. "Preduprezhdenie serdechno-sosudistykhoslozhneniy u patsientov s faktorami riskas pozitsii dokazatel'noy meditsiny." CardioSomatics 2, no. 1 (2011): 44–51. http://dx.doi.org/10.26442/cs44969.

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Summary. This review embraces the modern principles of cardiovascular disease prevention (CVD) as well as two important approaches to their prevention: non-drug treatments (correction of risk factors related to lifestyle) and drug treatments. Clinical effects and indications for use of such drug groups as antiplatelet agents, lipid-lowering drugs, angiotensin-converting enzyme are marked. The article focuses on the treatment characteristics of patients with multiple coronary risk factors. The results of clinical study on the antihypertensive effectiveness of Lisinopril in patients with high-ri

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Teplova, N. V., and D. V. Grishin. "Correction of endothelial dysfunction in COVID 19." Medical alphabet, no. 22 (October 20, 2020): 56–59. http://dx.doi.org/10.33667/2078-5631-2020-22-56-59.

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COVID‑19 is acute respiratory infection caused by the new coronavirus SARS-CoV‑2 (2019-nCoV). Until now, the pathogenesis of the virus has not been fully studied, but the global medical practice is dominated by the theory of systemic inflammation as the main damaging factor of viral infection. A special role is given to the study of the state of the endothelium. Understanding the molecular components underlying functional disorders and vascular damage, together with the ability of new laboratory technologies to determine the effect of endothelial damage on the entire body, provides a key to mo

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Chazova, I. E., and T. V. Martyniuk. "Diuretics in combination antihypertensive therapy: focus on forecast." Systemic Hypertension 13, no. 2 (2016): 6–10. http://dx.doi.org/10.26442/sg29120.

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In the modern therapy of arterial hypertension (AH) along with thiazide diuretics b-blockers, calcium antagonists, angiotensin converting enzyme inhibitors and angiotensin receptor blockers are considered for initial and maintenance of antihypertensive therapy in the form of mono - or combination therapy. Five of these classes of drugs have comparable antihypertensive effectiveness and proven impact on prognosis in accordance with the results of randomized controlled clinical trials. The most widely used in clinical practice for the treatment of patients with AH received thiazide diuretics. Th

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Sakhanda, І. V., K. L. Kosyachenko, Т. S. Nehoda, et al. "COMPARATIVE PHARMACOECONOMIC RESEARCH AND EVALUATION OF ENALAPRIL GENERICS IN TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION." Likarska sprava, no. 4 (June 16, 2019): 55–60. http://dx.doi.org/10.31640/jvd.4.2019(9).

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The number of people with cardiovascular diseases has increased significantly in recent years. According to statistics, diseases of the cardiovascular system occupy one of the first places among other diseases. One of the main pathologies in cardiology is hypertension. Treatment of arterial hypertension for a long period remains an important medico-social and economic task, a heavy financial burden falls on the patient himself or on the health care system, in the case of free distribution of drugs. The group of antihypertensive drugs is one of the most expensive, which raises the question of c

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Peleshok, K. Ye, L. S. Logoyda, and O. B. Poliak. "DEVELOPMENT AND METHODOLOGY FOR THE ESTIMATION OF ATENOLOL AND VALSARTAN IN PHARMACEUTICALS." Здобутки клінічної і експериментальної медицини, no. 1 (May 5, 2020): 30–33. http://dx.doi.org/10.11603/1811-2471.2020.v.i1.11066.

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According to the appropriate protocols for the treatment of hypertension are often used antihypertensive drugs of the 5 main classes – first-line drugs, which when used in equivalent doses contribute to the reduction of blood pressure and significantly reduce the risk of cardiovascular complications. Quite often, doctors prescribe two/three medicines at a time. Therefore, the creation of fixed combinations antihypertensive action in the form of solid dosage forms is an urgent task of modern pharmacy. The aim of the study – to improve to more rapid, simple, selective, less expensive metho

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Evsyutina, Yulia V. "National Medical Research Center for Preventive Medicine, Moscow, Russia." CardioSomatics 10, no. 4 (2019): 55–58. http://dx.doi.org/10.26442/22217185.2019.4.190597.

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Arterial hypertension is the leading cause of cardiovascular morbidity and mortality. According to Russian and international studies, prevalence of hypertension is approximately 40%. In the next years an increase in the number of patients can be expected. Hypertension is the main independent risk factor for coronary heart disease for all age groups. Modern antihypertensive drugs can provide good control of blood pressure and reduce the incidence of complications and mortality. By prescribing antihypertensive therapy, it is necessary to achieve the target level of blood pressure, for most patie

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Даурова, M. Daurova, Гатагонова, et al. "Pharmacoepidemiology of medicinal agents, used for the treatment of arterial hypertension in patients with chronic obstructive pulonary disease." Vladikavkaz Medico-Biological Bulletin 20, no. 30 (2014): 68–72. http://dx.doi.org/10.12737/12038.

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The article presents the results of pharmacoepidemiological study, conducted with the aim of studying the peculiarities of antihypertensive therapy in patients with arterial hypertension (AH), and chronic obstructive pulmonary isease (COPD) in the Republic North Ossetia-Alania. Retrospective descriptive study according to the medical records of patients (n=568) of all outpatient clinics of the republic was performed. According to the obtained data, recommended by the doctors, the therapy does not correspond with the modern clinical recommendations on the majority of cases. The main lacks of th

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Chazova, I. E., and Yu V. Zhernakova. "Calcium channel blockers: more than 50 years on guard of health." Systemic Hypertension 12, no. 2 (2015): 49–56. http://dx.doi.org/10.26442/sg29074.

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The class of drugs - calcium antagonists (CA), or calcium channel blockers (CCBs) is combined a quite heterogeneous drugs group possessing common vasodilatatory characteristics by disruption of the movement of calcium through the vascular smooth muscle cells and with different degree of impact on myocardium, the sinus node function, atrioventricular conduction, tonus of peripheral vessels and coronary blood flow. The existence of this class of drugs has become one of the great achievements in the field of pharmacology, at the end of the 20th century. Third Generation CCBs takes the special pla

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Mavromoustakos, Thomas. "Preface [Hot topic: Modern Aspects in the Design And Discovery of Novel Antihypertensive Drugs (Guest Editor: Thomas Mavromoustakos)]." Current Topics in Medicinal Chemistry 4, no. 4 (2004): i. http://dx.doi.org/10.2174/1568026043451366.

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Ostroumova, O. D., V. A. Dudaev, and V. M. Fomina. "The association of arterial hypertension and ischemic heart disease is the main problem in modern cardiology practice." Systemic Hypertension 12, no. 1 (2015): 70–75. http://dx.doi.org/10.26442/sg29101.

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This article deals with the epidemiological datashowing higher frequency of arterial hypertension (AH) in patients with ischemic heart disease (IHD). We discussed the basic characteristics of modern domestic and foreign recommendations for treating patients with combination of AH and IHD. We showed the target of blood pressure (BP) in this category of patients. This article deals with the priority groups of antihypertensive drugs, which have the advantages in the combination usage in patients with association of these diseases. We fixed special attention to the problem of BP variability (BPV)

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Aydarova, V. A., Z. T. Astahova, F. U. Kanukova, and M. M. Besaeva. "Assessing the impact of antihypertensive therapy on ambulatory blood pressure monitoring in patients with isolated systolic hypertension." CardioSomatics 5, no. 1 (2014): 5–9. http://dx.doi.org/10.26442/cs45038.

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The study examined the effectiveness of drug correction of high numbers of blood pressure (BP) by means of modern groups of antihypertensive drugs, the effect of a fixed combination of perindopril and indapamide on circadian blood pressure monitoring, and a commitment to patients of antihypertensive therapy, based on the opened simple randomization three groupswere formed: 1st comprised of 21 patients with isolated systolic hypertension (ISAH) and 22 patients with systolic-diastolic hypertension (SDAH) - they all received monotherapy with calcium antagonists (amlodipine 10 mg/day); Group 2 - o

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Kovalev, Dmitriy Sergeevich. "A clinical case of refractory arterial hypertension." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 4 (April 16, 2021): 56–63. http://dx.doi.org/10.33920/med-10-2104-08.

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Arterial hypertension is considered treatment refractory (resistant), if the treatment, involving a change (improvement) in lifestyle and a rational combined antihypertensive therapy, consisting of three drugs, including a diuretic, in the maximum tolerated doses does not lead to the achievement of the target blood pressure level. Pseudo-refractory and true refractory arterial hypertension are distinguished. According to modern data, true refractory arterial hypertension occurs in no more than 5 % of cases among the entire population of patients with arterial hypertension, however, in certain

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Ananicheva, Elena Viktorovna, Sergey Viktorovich Skalskiy, Ludmila Vladimirovna Shukil, Miroslava Valer'evna Petunina, Svetlana Aleksandrovna Paruchikova, and Ivan Valer'evich Paymanov. "Pharmacoepidemiological study of treatment managment in patients with type 2 diabetes mellitus in Omsk." Problems of Endocrinology 62, no. 1 (2016): 25–34. http://dx.doi.org/10.14341/probl201662125-34.

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Treatment management strategy for patients with type 2 diabetes mellitus (2DM) includes glycaemic control, blood pressure and lipid metabolism parameters. Pharmacoepidemiological monitoring allows evaluating the compliance of the treatment really provided for 2DM with the present guidelines.Aim.To study the actual implementation of pharmaceuticals control for patientswith type 2 diabetes, residents of the city of Omsk, in 2013—2014.Material and methods. It was a retrospective open cohort study based on the fragment data of the Regional Diabetes Register including 33 187 cases with prescription

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Bhokardankar, P. "CRITICAL REVIEW ON POTENTIAL AYURVEDIC DRUGS FUNCTIONAL IN HYPERTENSION." Journal of Medical pharmaceutical and allied sciences 10, no. 3 (2021): 3007–10. http://dx.doi.org/10.22270/jmpas.v10i3.1149.

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Hypertension is a lifestyle disorder in the modern era. Mostly the disorder is asymptomatic until it gets diagnosed. Hypertension for a longer duration if gets uncontrolled can cause the problems to the eye, kidney blood vessels, and other organs. It may cause heart attack, kidney failure, or retinal damages. In Ayurveda, there is a number of herbal drugs such as Elaeocarpus ganitrus Rauwolfia serpentine, Terminalia arjuna, Nordostachysjatamansi, Boerhaviadiffusa Brahmi vati, etc. used by the Ayurveda physicians to treat the condition of Hypertension. The utility of these drugs both by experim

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Azegami, Tatsuhiko, and Hiroshi Itoh. "Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension." International Journal of Hypertension 2019 (August 14, 2019): 1–8. http://dx.doi.org/10.1155/2019/9218531.

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Hypertension is a global public health issue and the most important preventable cause of cardiovascular diseases. Despite the clinical availability of many antihypertensive drugs, many hypertensive patients have poor medication adherence and blood pressure control due, at least partially, to the asymptomatic and chronic characteristics of hypertension. Immunotherapeutic approaches have the potential to improve medication adherence in hypertension because they induce prolonged therapeutic effects and need a low frequency of administration. The first attempts to reduce blood pressure by using va

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Savoia, Carmine, Massimo Volpe, Guido Grassi, Claudio Borghi, Enrico Agabiti Rosei, and Rhian M. Touyz. "Personalized medicine—a modern approach for the diagnosis and management of hypertension." Clinical Science 131, no. 22 (2017): 2671–85. http://dx.doi.org/10.1042/cs20160407.

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The main goal of treating hypertension is to reduce blood pressure to physiological levels and thereby prevent risk of cardiovascular disease and hypertension-associated target organ damage. Despite reductions in major risk factors and the availability of a plethora of effective antihypertensive drugs, the control of blood pressure to target values is still poor due to multiple factors including apparent drug resistance and lack of adherence. An explanation for this problem is related to the current reductionist and ‘trial-and-error’ approach in the management of hypertension, as we may oversi

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Vasyuk, Yu A., E. Yu Shupenina, E. N. Yuschuk, and G. A. Namazova. "Modern fixed combinations of antihypertensive drugs in the treatment of arterial hypertension and obesity: can this comorbid pathology be effectively controlled?" Russian Journal of Cardiology, no. 9 (September 8, 2019): 14–21. http://dx.doi.org/10.15829/1560-4071-2019-9-14-21.

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Aim. To assess the effect of azilsartan/chlortalidone and irbesartan/hydrochlorothiazide fixed combinations on office, daily peripheral and central blood pressure (BP), daily parameters of aortic stiffness and structural and functional state of the left ventricle in patients with arterial hypertension (AH) and obesity.Material and methods. The study included 46 patients with hypertension and obesity aged 35 to 55 years. In the beginning of the study and after 6 months of treatment with azilsartan/chlortalidone (AZL/C) or irbesartan/hydrochlorothiazide (IRB/H) all patients underwent a comprehen

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Bialik, Maria, Marzena Kuras, Marcin Sobczak, and Ewa Oledzka. "Achievements in Thermosensitive Gelling Systems for Rectal Administration." International Journal of Molecular Sciences 22, no. 11 (2021): 5500. http://dx.doi.org/10.3390/ijms22115500.

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Rectal drug delivery is an effective alternative to oral and parenteral treatments. This route allows for both local and systemic drug therapy. Traditional rectal dosage formulations have historically been used for localised treatments, including laxatives, hemorrhoid therapy and antipyretics. However, this form of drug dosage often feels alien and uncomfortable to a patient, encouraging refusal. The limitations of conventional solid suppositories can be overcome by creating a thermosensitive liquid suppository. Unfortunately, there are currently only a few studies describing their use in ther

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Melnik, M. V., I. I. Afonicheva, and A. A. Kazyulin. "The control of blood pressure level as the prevention of cognitive impairment." Systemic Hypertension 13, no. 4 (2016): 56–59. http://dx.doi.org/10.26442/sg29161.

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Today the prevalence of cognitive impairment is a large scale. At the end of the pathological process partial or complete, social, professional and common maladjustment and disability comes. One of the main factors of progression of cognitive impairment is a decrease in adherence to the therapy, forming a vicious circle of the underlying disease and its complications. In the article we examine the prevalence, pathogenesis and classification of cognitive impairment of patients with arterial hypertension, memory impairment, analyze the relationship of high blood pressure numbers. The use of mode

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Maschio, G., L. Oldrizzi, and C. Rugiu. "Is there a "point of no return" in progressive renal disease?" Journal of the American Society of Nephrology 2, no. 4 (1991): 832–40. http://dx.doi.org/10.1681/asn.v24832.

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The pathogenesis of progressive renal damage is most probably multifactorial. Whatever the mechanisms involved in renal disease progression, the existence of a "point of no return" has been hypothesized, that is, a stage of structural and functional damage beyond which progression of renal disease occurs independently of dietary measures and/or pharmacological treatment. In experimental animals, dietary protein and phosphate restriction is not fully successful in ameliorating the progression of functional deterioration if administered when renal injury is severe and long standing. Similarly, l

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Chazova, Irina E., Vera A. Nevzorova, Lali G. Ambatiello, et al. "Clinical practice guidelines on the diagnosis and treatment of patients with arterial hypertension and chronic obstructive pulmonary disease." Systemic Hypertension 17, no. 3 (2020): 7–34. http://dx.doi.org/10.26442/2075082x.2020.3.200294.

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One of the most common comorbid condition in people over 40 years old is: arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD). The frequency of AH in patients with COPD varies from 6.8 to 76.3%, in average 34.3%. COPD is detected in every fourth patient with hypertension in the age group of 2564 years. The current trend towards an increase in life expectancy and therefore growing pool of elder cohort, will lead to a higher number of patients with comorbid disorders. Diagnosis and treatment of AH and COPD are determined by current clinical recommendations for both nosolo

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Khramchenko, M. A., A. D. Karpenkova, M. M. Petrova, and D. S. Kaskaeva. "Tactics features for managing out-patients with cardiovascular comorbidity in Krasnoyarsk city." Siberian Medical Review, no. 5 (2020): 63–69. http://dx.doi.org/10.20333/2500136-2020-5-63-69.

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The aim of the research is to study the structure of cardiovascular continuum within comorbid pathology within outpatient clinic of Krasnoyarsk; to evaluate the quality of out-patients management in accordance with modern clinical guidelines. Material and methods. To conduct a single retrospective analysis, 1928 medical records of Krasnoyarsk cardiovascular out-patients were taken. All the patients consulted local therapists in 2018. Differences were statistically significant at p <0.05. Results. Comorbid pathology is observed in patients with CVD in 87% of cases, and its growth is noted wi

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Korokina, Liliya V., Ivan V. Golubev, Olga N. Pokopejko, Anastasia V. Zagrebelnaya, and Sergey A. Demchenko. "Search for new pharmacological targets for increasing the efficiency of correction of cardiovascular diseases." Research Results in Pharmacology 5, no. 3 (2019): 67–77. http://dx.doi.org/10.3897/rrpharmacology.5.39521.

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Introduction: Cardiovascular disease (CVD) is the leading cause of death worldwide: no other reason causes as many deaths a year as CVD. An estimated 17.9 million people died of CVD in 2016, accounting for 31% of all deaths in the world. People with CVD or at high risk for these diseases (due to one or more risk factors, such as high blood pressure, diabetes, hyperlipidemia, or an already developed disease) need early detection and assistance through counseling and, if necessary, taking medication. Ways to find new targets for the correction of endothelium-associated pathology: The basis of th

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Zhuravleva, A. N., and M. V. Zueva. "Hypotensive glaucoma therapy and neuroprotection." Russian Ophthalmological Journal 13, no. 2 (2020): 78–82. http://dx.doi.org/10.21516/2072-0076-2020-13-2-78-82.

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Most modern antihypertensive drugs used in the treatment of primary open-angle glaucoma have an indirect neuroprotective effect not only because they reduce intraocular pressure (IOP), but also because of a stimulating effect on the natural metabolic processes in the eye. Researchers and clinicians today follow the strategy of compensating IOP, starting from the earliest stages of glaucomatous optic neuropathy (GON), regardless of which drug (generic or original) reduces IOP and which combination of the main active substances this drug has. The need for neuroprotective therapy in clinical prac

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Pavlova, Tatiana V., Dmitrii V. Dupliakov, Dmitrii V. Dupliakov, Sofiia A. Vorontsova, and Galina N. Guseva. "Clinical case of a successful treatment of uncontrolled arterial hypertension in a 67-year-old patient with captopril." Consilium Medicum 23, no. 1 (2021): 74–79. http://dx.doi.org/10.26442/20751753.2021.1.200605.

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Effective blood pressure (BP) control remains an actual problem – according to the results of the multicenter study ESSE-RF, only 11.3% of women and 7.6% of men achieve it. Inadequate treatment of arterial hypertension often leads to clinically significant increase of BP without signs of damage to target organs. Such patients should be treated in out-patient setting by oral antihypertensive medications according to modern algorithms. It is also necessary to prescribe medications for subsequent long-term control of BP, if the patient has not previously taken them, or to optimize this type of th

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Vasilevskaya, O. V., D. D. Safina, and I. V. Silant’eva. "Causes of non-effectiveness of secondary prophylaxis of ischemic stroke." Kazan medical journal 93, no. 5 (2012): 744–48. http://dx.doi.org/10.17816/kmj1701.

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Aim. To study the aspects of prevention and risk factors of a recurrent ischemic stroke. Methods. 50 patients who suffered a recurrent ischemic stroke in the period from October 2010 to February 2011 participated in the study. Past medical history information was obtained according to a specially designed questionnaire. Information on the regularity of medication administration (antihypertensive, antithrombotic, lipid lowering), maintenance of a diet, and modes of physical activity was collected. Results. The main measure of prevention of thrombosis in patients after an ischemic stroke was ace

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Ebzeeva, E. Yu, O. D. Ostroumova, N. M. Doldo, and E. E. Pavleeva. "Fixed combination in patients with arterial hypertension: focus on antihypertensive and nephroprotective properties of fixed combination of lisinopril and amlodipine (clinical example)." Medical alphabet, no. 21 (October 15, 2020): 19–28. http://dx.doi.org/10.33667/2078-5631-2020-21-19-28.

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Arterial hypertension (AH) remains one of the most significant medical and social problems in the world, its prevalence among the adult population is 30–45%. Along with this, the modern population is characterized by a high incidence of chronic kidney disease (CKD), including due to their secondary damage in the framework of hypertension. In turn, CKD is an important independent risk factor for the development and progression of cardiovascular diseases, including fatal ones. The use of existing approaches to nephroprotection in the treatment of patients with hypertension will significantly imp

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Xiong, Xingjiang, Xiaochen Yang, Wei Liu, Fuyong Chu, Pengqian Wang, and Jie Wang. "Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/275279.

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Hypertension is a major public-health issue. Much consensus has been reached in the treatment, and considerable progress has been made in the field of antihypertensive drugs. However, the standard-reaching rate of blood pressure is far from satisfaction. Considering these data and the seriousness of the effects of hypertension on the individual and society as a whole, both economically and socially, physicians must look for more effective and alternative ways to achieve the target blood pressure. Could treatment of hypertension be improved by insights from traditional Chinese medicine? As one

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Kanorskiy, S. G. "Treatment of hypertension during the COVID-19 pandemic: questions about the blockade of the renin-angiotensin-aldosterone system." Meditsinskiy sovet = Medical Council, no. 4 (April 20, 2021): 59–67. http://dx.doi.org/10.21518/2079-701x2021-4-59-67.

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Arterial hypertension was one of the most common comorbidities associated with a high risk of death in hospitalized patients with COVID-19. Patients with hypertension are routinely and according to standards treated with angiotensinconverting enzyme inhibitors (ACE inhibitors) or angiotensin receptor blockers (ARB) II. ACE inhibitors or ARB II are included in fixed combinations of antihypertensive drugs recommended for patients with uncomplicated hypertension, as well as when combined with various comorbidities. During the COVID-19 pandemic, there were suggestions about the potential for a neg

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