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Journal articles on the topic 'Modern methods of granulation'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Patil, Mr Guruprasad Nagraj. "Study the Modern Techniques of Granulation in Pharmaceutical Solid Dosage Form." International Journal for Research in Applied Science and Engineering Technology 13, no. 5 (2025): 5713–17. https://doi.org/10.22214/ijraset.2025.71532.

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Granulation is a critical process in the pharmaceutical industry, significantly influencing the manufacturing and quality of solid dosage forms such as tablets and capsules. Traditional granulation methods, including wet and dry granulation, have been widely employed for decades. However, modern pharmaceutical demands necessitate advanced granulation technologies that offer enhanced process control, scalability, product uniformity, and compliance with regulatory expectations such as Quality by Design (QbD) and Process Analytical Technology (PAT). This study explores the latest advancements in

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Setiani, Wahyu Sri, Mala Utami, Winka W. Yunanda, et al. "The Granulation Methods of Double Base Propellant for Small Caliber Ammunition: A Review." International Journal of Social Science Research and Review 6, no. 1 (2023): 247–51. http://dx.doi.org/10.47814/ijssrr.v6i1.758.

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One of the most essential unit procedures in propellant production is granulation, or particle enlargement through agglomeration. The granulation process transforms small fine or coarse particles into huge agglomerates known as granules. The granulation process converts fine powders into free-flowing, dust-free granules that are easier to compress, affecting propellant grain size. The propellant industry expects produce quality propellant which can increase the performance of weapon. Method of propellant granulation should have optimized in accordance with the size of grain. One of the most ac

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Rubiyanto, Warja. "Support Granulation using Acupuncture Method: Diabetic Foot Ulcer Case Study." International Journal of Innovative Science and Research Technology 7, no. 4 (2022): 594–97. https://doi.org/10.5281/zenodo.6525934.

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Indonesia is the country with the fourth most diabetes mellitus patient in the world after India, China, and the United States, 12 million patient and is expected to increase to 21.3 million in 2030. Diabetic foot ulcers (DFU) is a complication of diabetes that is hard to heal and can even end in amputation due to infectioncauseof not handled properly. The incidence of diabetic foot ulcers reaches 25% and the overall prevalence reaches 6.3% of all diabetes mellitus patients in each country (JWC Int, 2018). The UK reports the effect of diabetes mellitus 20% on diabetic foot ulcers (National Hea

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Роїк, О. М., and О. П. Голодюк. "Technology for obtaining a highly soluble dispersion of atorvastatin to increase bioavailability." Farmatsevtychnyi zhurnal, no. 4 (August 26, 2024): 52–62. http://dx.doi.org/10.32352/0367-3057.4.24.05.

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The technology of formation of solid dispersed systems (SDS) is a technological approach that allows to increase the rate of release and bioavailability of poorly soluble active pharmaceutical ingredients (APIs) that belong to class II and IV of the biopharmaceutical classification system (BCS). Atorvastatin calcium is a class II/IV drug according to BCS, which exhibits low bioavailability due to insufficient dissolution. The aim of the work was to conduct a literature and patent search for promising technologies for obtaining highly soluble SDS for effective use in order to increase the solub

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Nichvolodin, Kostiantyn, Vsevolod Sklabinskyi, and Oleksandr Yurchenko. "Determination of the temperature of mineral fertiliser granules after contact with the air in a granulation tower." Technology audit and production reserves 4, no. 3(78) (2024): 28–32. http://dx.doi.org/10.15587/2706-5448.2024.310855.

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The object of research is the process of cooling mineral fertilizer granules in a granulation tower. The main problem that was solved was the analysis of the temperature mode of cooling the granules to increase their strength and quality, as well as to reduce the probability of their destruction during storage and transportation. The design of a rotating vibrating granulator (RVG) and a mathematical model for calculating the temperature of granules and air at different stages of the granulation process are presented. Reynolds, Peclet and Prandtl criteria are used to describe hydrodynamic and t

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Artemov, Arseny O., Stanislav V. Naumov, and Michael N. Ignatov. "Technology and Equipment for Plasma Electric Arc Granulation of Fused Welding Flux." Materials Science Forum 946 (February 2019): 389–94. http://dx.doi.org/10.4028/www.scientific.net/msf.946.389.

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The article outlines the main principles of granulation technology for fused welding flux using highly concentrated heat sources (e.g. plasma arc). Modern plasma equipment and methods of its use for producing new welding materials (plasma-granulated welding flux) from mineral raw materials and synthetic mineral alloys are described. The developed technology makes it possible to produce granulated flux in a wide range of fractional composition (from 0.2 to 3 mm). Studies have focused on the influence of granulation regimes (plasmatron moving speed, current, voltage, arc length) on formation pro

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Zakharov, Nikolai M., Evgeny V. Ilyin, and Ramil G. Khasanov. "DEVELOPMENT OF TECHNICAL SOLUTIONS FOR MODERNIZATION OF POLYETHYLENE WAX GRANULATION UNIT." Oil and Gas Business, no. 3 (June 7, 2024): 247–64. http://dx.doi.org/10.17122/ogbus-2024-3-247-264.

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Industrial development trends in the Russian Federation actualize a number of important issues for the production sites of the petrochemical complex. Such issues include problems at enterprises related to environmental aspects and working conditions at the processing and disposal units of by-products and waste products.Polyethylene wax is a by-product of the polymerization reaction of ethylene. As part of solving the above problems related to the production of polyethylene, modern methods of melt granulation have been studied.The analysis of the parameters of the active polyethylene wax extrac

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Kutnyashenko, Oleksii, and Vitaliy Kints. "SELECTION AND JUSTIFICATION OF PRELIMINARY MECHANICAL TREATMENT METHOD OF FINELY-DISPERSED FRACTION OF SOLID WASTE BEFORE DISPOSAL." Journal of “Problems of Ecology”, no. 1 (2021): 52–63. http://dx.doi.org/10.31474/2073-8102-2021-1-52-63.

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Introduction. Every year in Ukraine about 40-50 million tons are dumped in landfills. household waste, of which only no more than 2 million tons are processed and disposed of. To date, more than 15 billion tons of waste have been accumulated in landfills. Insufficient number of official, registered and equipped landfills, lack of modern landfills, as well as insufficient level of waste disposal are the reasons for the emergence of so-called unauthorized landfills, often located within the city. Problem Statement. To date, the processes of utilization of fine fractions of waste, which include t

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Komkov, Konstantin N., Igor V. Chmyrev, and Vasiliy A. Kozyaev. "Pathogenetic features of post-burn skin scarring: modern methods of early treatment and prevention (review)." Saratov Journal of Medical Scientific Research 21, no. 1 (2025): 30–36. https://doi.org/10.15275/ssmj2101030.

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Objective: to analyze the effectiveness of modern methods of prevention and early treatment of scarring in burned patients, taking into account pathogenetic mechanisms. The methodology of writing a review. The review was performed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology using the eLibrary, PubMed, and Medline databases. The search depth is from 2003 to 2024. Number of sources viewed —1372. The review includes 16 original studies. The most effective and widely used methods of early treatment and prevention of scars in burned patients hav

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Lozhkomoev, A. S., N. V. Kirilova, and O. V. Bakina. "Modern dressing based on polymer microfibers with aluminum oxyhydroxide: properties and mechanism of wound healing." Wounds and wound infections. The prof. B.M. Kostyuchenok journal 7, no. 1 (2020): 46–57. http://dx.doi.org/10.25199/2408-9613-2020-7-1-46-57.

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Objective: to investigate the structure of the new VitaVallis dressing and determine the mechanism of its wound healing effect. Materials and methods. To study the structure of the VitaVallis dressing, transmission and scanning electron microscopy methods were used. The course of the wound process was studied in 60 male mice of the Balb / c line. The healing of a wound defect under the influence of dressings was studied on the model of a “skin flap”. Morphometric evaluation of histological preparations was carried out by computer-aided graphical analysis of samples. Statistical processing of t

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Semenov, Boris, Anna Nazarova, Tatiana Kuznetsova, Maria Sergeeva, and Anna Kozitcyna. "Moist wound healing after mast cell tumor surgical removal in a dog." E3S Web of Conferences 254 (2021): 09008. http://dx.doi.org/10.1051/e3sconf/202125409008.

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Study of various wound healing methods is a relevant issue of modern veterinary medicine. One of the investigated methods of wound healing is moist wound healing in a hydrated environment using hydrogel patches. In described clinical case, an eight-year-old female American Pit Bull Terrier was subjected to mast cell tumor surgical removal on the left hindlimb. During the patient postoperative treatment, Sorbalgon®, Hydrocoll® and HydroClean® dressings were used to protect the surgical site and maintain high moist environment in the wound. The dressings absorbed wound exudate and stimulated bot

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Pinich, I. "Modern Techniques of Developing Students’ Emotional Intelligence." Vìsnik KNLU. Serìâ “Psihologìâ ta Pedagogìka” / Visnyk KNLU. Series "Pedagogy and Psychology" 40 (September 6, 2024): 22–38. http://dx.doi.org/10.32589/2412-9283.40.2024.309796.

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Introduction. The evolving role of social, emotional, and ethical learning (SEEL) necessitates the growth of its stakeholders in Ukrainian higher educational institutions. The lack of consistency and continuity in SEEL from secondary basic education to higher education calls for effective strategies to bridge the gap. Purpose. This article aims to investigate current trends for strategically organizing SEEL and to provide an inventory of optimal tools for its implementation in Ukrainian higher educational institutions. The objectives are outlined as follows: 1) provide an overview of world and

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Egorova, S. N., I. V. Bulygina, N. V. Vorobeva, D. P. Chuvashova, and N. R. Mustafina. "Modern Approaches to the Technology of Tablet Dosage Forms of Thioctic Acid (Review)." Drug development & registration 10, no. 2 (2021): 32–41. http://dx.doi.org/10.33380/2305-2066-2021-10-2-32-41.

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Introduction. Thioctic (α-lipoic) acid is an endogenous antioxidant and is used for liver diseases, poisoning with salts of heavy metals, hyperlipidemia, atherosclerotic heart disease, neuropathy, insulin-resistant forms of diabetes mellitus, etc. technologies for producing tableted medicinal preparations of thioctic acid, necessary for the pharmaceutical development of thioctic acid tablets at pharmaceutical industry enterprises.Text. The review considers the physicochemical properties of the pharmaceutical substance thioctic acid, the features of its pharmaceutical and technological properti

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Kalashnikova, G. O., V. N. Yakovenchuk, E. A. Selivanova, Ya A. Pakhomovsky, and D. V. Gryaznova. "THE WAY OF DEVELOPMENT OF NATURAL LINTISITE FROM A MINERAL TO ITS SYNTHETIC ANALOGUE: USEFUL PROPERTIES, POTENTIAL AREAS OF PRACTICAL APPLICATION." Herald of the Kola Science Centre of the RAS 13, no. 2-2021 (2021): 7–16. http://dx.doi.org/10.37614/2307-5228.2021.13.2.001.

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The article presents a general description of lintisite – a rare mineral of the Khibiny and Lovozersky alkaline massifs. The mineral is considered as a base for the creation of a number of new interesting and useful substances for the modern science of materials. The characteristics of a natural sample are compared with its synthetic analogue AM-4. Examples of potential applications of AM-4 and its new form as the "nano-scale puzzle" for the field of organic synthesis are given. Different methods of AM-4 granulation are shown. The text is presented as a science fiction in order to attract the

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15

Naumov, Stanislav V., Michael N. Ignatov, and M. A. Sheksheev. "Technology of Mineral Raw Materials Granulation by Electric Arc for Manufacturing of Welding Fused Flux." Solid State Phenomena 265 (September 2017): 290–95. http://dx.doi.org/10.4028/www.scientific.net/ssp.265.290.

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The research and description of modern methods and procedure of welding flux manufacture are presented. The technology of welding fused flux production by influencing on the composition of mineral raw materials furnace burden (from 0,5 mic up to 0,20 mm) with electric arc (diameter graphite electrodes 6-18 mm, current from 200 up to 600 A) is proposed to be significantly reducing the labor input as well as dustiness during the operation and transport and improves mechanical properties (granules strength of 16-19 N/mm2) and surface condition of flux granules. The equipment for the granulation d

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16

Almakaiev, Maksym, and Larysa Sidenko. "Substantiation of technology for obtaining capsules of a multi-component drug with neurotropic action." ScienceRise: Pharmaceutical Science, no. 1 (29) (February 27, 2021): 10–16. http://dx.doi.org/10.15587/2519-4852.2021.225284.

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The aim of the work. Theoretical and experimental substantiation of a rational technology for obtaining a preparation in the form of capsules based on uridine-5-monophosphate of disodium salt, cytidine-5-monophosphate of disodium salt, vitamin B6, thioctic acid and magnesium lactate dihydrate, determination of process parameters that can affect critical quality characteristics active pharmaceutical ingredients in the product and establishing acceptance criteria for each critical process parameter to be used in batch production and process control. Materials and methods. Objects of the re

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Maksym, Almakaiev, and Sidenko Larysa. "Substantiation of technology for obtaining capsules of a multi-component drug with neurotropic action." ScienceRise: Pharmaceutical Science, no. 1(29) (February 27, 2021): 10–16. https://doi.org/10.15587/2519-4852.2021.225284.

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<strong>The aim of the work.</strong> Theoretical and experimental substantiation of a rational technology for obtaining a preparation in the form of capsules based on uridine-5-monophosphate of disodium salt, cytidine-5-monophosphate of disodium salt, vitamin B<sub>6</sub>, thioctic acid and magnesium lactate dihydrate, determination of process parameters that can affect critical quality characteristics active pharmaceutical ingredients in the product and establishing acceptance criteria for each critical process parameter to be used in batch production and process control. <strong>Mater

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Ferawati, Ferawati. "APLIKASI PERAWATAN LUKA DENGAN MENGGUNAKAN ENZYMATIK THERAPY: ALOE VERA DALAM MANAJEMEN LUKA DIABETES." Journal of Health Sciences 11, no. 2 (2018): 121–29. http://dx.doi.org/10.33086/jhs.v11i2.104.

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Introduction:Diabetes mellitus is a metabolic disease group will facilitate the occurrence of diabetic foot wounds. To prevent the complications of diabetic wound that lasts longer and prevents the worse then takes care of wounds in diabetics. Latest wound care techniques are already using a bandage. The principle of modern wound treatment products is to maintain and keep the environment humid permanent cuts to facilitate the process of wound healing, maintaining the loss of fluid networks and cell death. Objective: this study aimed to find out how the application methods of wound care u

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Dimantika, Alberikus, Sugiyarto Sugiyarto, and Yuyun Setyorini. "Perawatan Luka Diabetes Mellitus Menggunakan Teknik Modern Dressing." Interest : Jurnal Ilmu Kesehatan 9, no. 2 (2020): 160–72. http://dx.doi.org/10.37341/interest.v9i2.210.

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Background: The most common complication in patients with diabetes mellitus tippe 2 (DM) is diabetic ulcers, where the tissue deformity occurs either partially (Partial Thickness) or completely (Full Thickness). If not handled properly and appropriately, ulcers can become infected. Where leg ulcers, infection, neuroarthropathy and peripheral artery disease are the causes of gangrene and lower limb amputations. The aim of this study is to determine the effectiveness of wound healing in the treatment of diabetes mellitus wounds using modern dressing techniques. Methods: the literature review (LR

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Darie-Ion, Laura, Madhuri Jayathirtha, Gabriela Elena Hitruc, et al. "A Proteomic Approach to Identify Zein Proteins upon Eco-Friendly Ultrasound-Based Extraction." Biomolecules 11, no. 12 (2021): 1838. http://dx.doi.org/10.3390/biom11121838.

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Zein is a type of prolamin storage protein that has a variety of biomedical and industrial applications. Due to the considerable genetic variability and polyploidity of the starting material, as well as the extraction methods used, the characterization of the protein composition of zein requires a combination of different analytical processes. Therefore, we combined modern analytical methods such as mass spectrometry (MS), Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), atomic force microscopy (AFM), or Fourier transform infrared spectroscopy–attenuated total reflectance

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Іvanova, Yu V., S. M. Gramatyuk, І. A. Kryvoruchko, O. O. Zarudnyi, and K. V. Miasoiedov. "Photodynamic therapy in treatment of trophic ulcers in patients, suffering chronic venous insufficiency." Klinicheskaia khirurgiia 88, no. 7-8 (2021): 32–38. http://dx.doi.org/10.26779/2522-1396.2021.7-8.32.

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Objective. Elaboration of complex approach to treatment of trophic ulcers of venous etiology, using photodynamical tissue therapy and modern types of the wound coverage. Materials and methods. Into the investigation 24 patients were included, suffering venous ulcers on background of postthrombophlebitic disease and ageing from 31 to 79 yrs old. Into the comparison group there were included 14 patients, in whom a standard treatment (venotonic preparations, elastic compression, local application of multicomponent ointments depending on the wound phase present) was used. Into the main group

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Samashev, Zainolla, Aidos Erbulatovich Chotbaev, Nikolai Sergeevich Kurganov, et al. "Natural scientific methods in exploration of reference monuments of the Saka Culture in Kazakh Altai." Genesis: исторические исследования, no. 9 (September 2020): 21–31. http://dx.doi.org/10.25136/2409-868x.2020.9.33885.

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This article explores the ancient gold jewelry with inlay, which were discovered in the process of archeological studies conducted in Summer 2018 of grave complexes located on the Eleke Sazy Plateau, Tarbagatay Ridge in East Kazakhstan Region in the burial of a young man belonging to aristocratic ancestry. It refers to the Saka culture, and dates back to approximately VIII-VII centuries BC. Among the discovered objects were garments embroidered with gold, quiver with arrows, and a bronze dagger in gold scabbard. This work studied the golden scabbard for dagger. The scabbard consists of several

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Marcjasz, Piotr, Anna Bioły, Agnieszka Buliszak, Monika Babczyńska, Agnieszka Borończyk, and Piotr Zając. "Negative Pressure Wound Therapy in Surgical Wound Management: Mechanisms, Clinical Outcomes, and Comparative Analysis of Modern NPWT Systems." Quality in Sport 40 (April 22, 2025): 59833. https://doi.org/10.12775/qs.2025.40.59833.

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Introduction: Surgical wounds that fail to heal or that develop complications such as infection or dehiscence are challenging problem that health care has to deal with everyday. Negative Pressure Wound Therapy (NPWT) has emerged as an important tool for managing complex wounds. This review aims to summarize the mechanisms by which NPWT supports wound healing, estimate the clinical efficacy of NPWT in surgical wounds and compare available NPWT systems. Materials and methods: A literature review was conducted using the databases such as Pubmed and Google Scholar. State of Knowledge: NPWT involve

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Kryvoruchko, I. A., I. V. Sorokina, K. Yu Parhomenko, T. M. Firsyk, and O. P. Bozhko. "THE ROLE OF SOME CYTOKINES IN THE FORMATION OF CRYPTOGLANDULAR ANAL FISTULA." Kharkiv Surgical School, no. 2 (June 20, 2021): 27–32. http://dx.doi.org/10.37699/2308-7005.2.2021.05.

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Abstract. Aim. Modern surgical approaches to the treatment of anal fistulas involve operations that least damage the sphincter complex of the rectum. The essence of the operation is a complete excision of the anal fistula, which is often accompanied by a significant number of recurrences depending on the chosen method of operation. Failure is likely the result of inflammation that persists after surgery, and cytokines play an important role in these processes. The aim of the study: evaluate local production and determine the role of IL-6 and TNFα in the formation of rectal fistulas.&#x0D

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Pakhomova, R. A., Y. S. Vinnik, L. V. Kochetova, A. M. Babajanyan, V. A. Kashintsev, and D. P. Kuzmenko. "Advancements and Applications of Adipose-Derived Stem Cells in Modern Medicine: A Comprehensive Review." Surgical practice (Russia), no. 2 (July 16, 2024): 69–79. http://dx.doi.org/10.5922/2223-2427-2024-9-2-5.

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The literature review examines the significant role of adipose-derived stem cells (ASCs) as a segment of mesenchymal stem cells in modern medicine. ASCs possess unique characteristics, such as a high ability to differentiate and regenerate, making them a valuable resource in regenerative medicine and therapy. The review focuses on methods for isolating and cultivating ASCs and emphasizes the importance of adhering to standards for monitoring the cultivation and storage processes of stem cells. The molecular and cellular characteristics that enable the use of ASCs in various medical fields, inc

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Ivanusa, Sergei Yа, Boris V. Risman, Rauan E. Shayakhmetov, Andrey V. Yanishevskiy, Maria V. Babenko, and Pavel A. Shipilov. "Computer planimetry as an objective control method for wound healing in diabetic foot syndrome." Bulletin of the Russian Military Medical Academy 25, no. 2 (2023): 239–48. http://dx.doi.org/10.17816/brmma321607.

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ABSTRACT. The study evaluated the results of treating patients with infectious complications of diabetic foot syndrome using minimally invasive endovideosurgical methods of computer planimetry with the Russian program AnaliRan in conjunction with traditional and endovideoscopic methods. The technique employed significantly reduced the treatment duration for this patient population. The technique employed significantly reduced the treatment duration for this patient population. This study provided valuable insights into the most effective ways of assessing the dynamics of the wound process. Des

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Shabunin, A. V., I. P. Parfenov, P. A. Drozdov, et al. "Benefits of vacuum-assisted closure therapy over standard treatments for infected and chronic non-healing wounds after kidney transplantation." Russian Journal of Transplantology and Artificial Organs 23, no. 1 (2021): 24–29. http://dx.doi.org/10.15825/1995-1191-2021-1-24-29.

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Objective: to evaluate the effectiveness of vacuum-assisted closure (VAC) therapy in comparison with standard treatments for infected and chronic non-healing wounds after kidney transplantation. Materials and methods. From June 2018 to November 2019, 75 kidney transplants from deceased donors were performed at the Transplantation Ward of Botkin City Clinical Hospital. There were 47 men (62.6%) and 28 women (37.4%). Standard surgical technique was used. Immunosuppressive therapy was carried out according to a three-component scheme with anti-CD25 monoclonal antibody induction (basiliximab) intr

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Bubman, Leonid I., Svetlana V. Topolyanskaya, Ilya M. Buriev, Igor P. Marchenko, and Georgy G. Melkonyan. "Negative pressure wound therapy in patients with combat limb injuries: literature review." Clinical review for general practice 5, no. 6 (2024): 33–41. http://dx.doi.org/10.47407/kr2024.5.6.00432.

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The review reflects modern vision about combat injuries. Particular attention is paid to injuries of the extremities and methods of their treatment. Despite advances in surgical techniques and medical technology, treating extremity combat injuries remains challenging. Regular debridement, local negative pressure wound therapy, and reconstructive surgery are currently considered the mainstay of treatment for these types of high-energy injuries. The limited literature suggests that the use of local negative pressure wound therapy in the treatment of high-energy combat wounds of the extremities r

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Hu, Michael S., Mimi R. Borrelli, H. Peter Lorenz, Michael T. Longaker, and Derrick C. Wan. "Mesenchymal Stromal Cells and Cutaneous Wound Healing: A Comprehensive Review of the Background, Role, and Therapeutic Potential." Stem Cells International 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/6901983.

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Cutaneous wound repair is a highly coordinated cascade of cellular responses to injury which restores the epidermal integrity and its barrier functions. Even under optimal healing conditions, normal wound repair of adult human skin is imperfect and delayed healing and scarring are frequent occurrences. Dysregulated wound healing is a major concern for global healthcare, and, given the rise in diabetic and aging populations, this medicoeconomic disease burden will continue to rise. Therapies to reliably improve nonhealing wounds and reduce scarring are currently unavailable. Mesenchymal stromal

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Shyrko, A. Yu, M. M. Vasenda, L. I. Будняк, and O. O. Pokotylo. "The choice of excipients to obtain tablets based on the Primula denticulate Smith. Extract by wet granulation." Ukrainian biopharmaceutical journal, no. 1(66) (April 12, 2021): 4–9. http://dx.doi.org/10.24959/ubphj.21.296.

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Introduction. Herbal medicines are increasingly being used in the treatment of various diseases. Significant number of resources, high-level availability and the possibility of cultivation have provided high prospects of plant raw materials in the development of new herbal medicines. Primula denticulate Smith. is one of the most interesting medicinal plant raw materials source in modern medicine and pharmacy with the wide spectrum of pharmacotherapeutic action, that is mainly used only in traditional medicine. Thus, nowadays the development of new and effective medicines based on Primula denti

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Salfo, Ouédraogo, Atchadé Constantin, Traoré Kadiatou, et al. "Formulation of Effervescent Granules Based on <i>Calotropis procera</i> Ait Powder (Apocynaceae) and <i>Zanthoxylum zanthoxyloides</i> Lam (Rutaceae)." Pharmaceutical Science and Technology 9, no. 1 (2025): 17–26. https://doi.org/10.11648/j.pst.20250901.13.

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Introduction: Sickle cell disease is a genetic disease that affects nearly 5% of the world&apos;s population and is particularly prevalent in sub-Saharan Africa. The inaccessibility of modern treatment has led to the development of a phytomedicine called FACA® in Burkina Faso. It is formulated in capsule form and contains a mixture of powdered root barks of &lt;i&gt;Zanthoxylum zanthoxyloides&lt;/i&gt; and &lt;i&gt;Calotropis procera&lt;/i&gt;. This study aims to propose an alternative, easier-to-administer form for patients who have difficulty swallowing ca

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Pavlov, A. V., S. S. Maskin, and L. A. Igolkina. "Acceleraion of Healing of Experimentally Modeled Septic Wounds with Use of Local Cryotherapy." NAUKA MOLODYKH (Eruditio Juvenium) 10, no. 4 (2022): 391–400. http://dx.doi.org/10.23888/hmj2022104391-400.

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BACKGROUND: Purulent diseases of the skin and subcutaneous tissue remain a widespread and urgent problem. The most promising methods of treatment with the active use of physical factors affecting the purulent focus are in the conditions of modern increasing resistance of microorganisms. AIM: To determine the effect of local ultra-low temperatures on the inflammatory and reparative processes in an experimental septic wound of soft tissues for planning a subsequent clinical study of the effectiveness of debridement using cryotherapy. MATERIALS AND METHODS: The experiment was conducted on 40 Wist

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Zurnadzh'yants, V. A., E. A. Kchibekov, R. M. Ragimov, and K. Yu Melnikova. "Modern aspects of the monitoring of a burn wound readiness for autodermoplasty." Astrakhan medical journal 19, no. 1 (2024): 76–84. http://dx.doi.org/10.17021/1992-6499-2024-1-76-84.

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The leading principle of burned patients’ treatment is to perform free autodermoplasty with split autodermografts. The main criterion for a successful plastic surgery is the percentage of engraftment of skin grafts. The issues of readiness of burn wounds for such surgical interventions continue to be studied and remain open at the present time. The degree of readiness of burn wounds for skin grafting is known to depend on many factors, among which the state of the microbial flora and the level of bacterial contamination of the wound surface play an important role as one of the main criteria fo

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Rashed, Aref, János Fülöp, Lóránd Caicut, Roland Tóth, and Rezan Watti. "A negatív nyomású sebkezelés helye a modern sebészetben." Orvosi Hetilap 163, no. 7 (2022): 271–78. http://dx.doi.org/10.1556/650.2022.32369.

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Összefoglaló. A negatív nyomású sebkezelés mai formájában történő, a mindennapos sebészi gyakorlatba történő bevezetése az 1990-es években történt meg. A kezelés célja a váladék elszívása mellett a mikrocirkuláció javítása és a seb granulációs folyamatainak serkentése. A modern sebkezelési szemlélettel a fenti módszert alkalmazhatjuk akut és krónikus sebgyógyulási zavarok esetében egyaránt, használatához azonban fontos a megfelelően szakképzett személyzet és a jól kiválasztott beteg egyaránt. Összefoglalásunkban arra vállalkoztunk, hogy ismertetjük a negatív nyomású rendszer alkotórészeit, a s

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Umnikov, A. S., I. I. Glazko, E. I. Balakin, A. S. Samoilov, and V. I. Pustovoit. "Modern strategies for the prevention and treatment of post-burn scars (a systematic review)." Russian Journal of Transplantology and Artificial Organs 27, no. 2 (2025): 148–62. https://doi.org/10.15825/1995-1191-2025-2-148-162.

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Despite advancements in modern reconstructive surgery, preventing the formation of thick scar tissue that impairs limb function or causes cosmetic defects remains a critical challenge. Equally important is the effective correction of existing scars to optimize both functional and aesthetic outcomes. Severe functional impairment of the upper limbs can result in disability. A combination of surgical and nonsurgical interventions is essential to enhance functionality while minimizing the risk of scar recurrence. Platelet-rich plasma injections, stem cell therapy, adipose tissue transplantation, a

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Biletskyi, Volodymyr, Tetiana Oliinyk, Serhii Pysmennyi, Liudmyla Skliar, Serhii Fedorenko, and Serhii Chukharev. "Experimental studies of the joint process “hydrotransport – oil agglomeration of coal”." Mining of Mineral Deposits 18, no. 4 (2024): 71–79. https://doi.org/10.33271/mining18.04.071.

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Purpose. Development of highly effective dewatering methods along with preservation of technological properties of hydro-transported coal is one of the key tasks for improving modern pipeline hydrotransportation systems. Accordingly, the purpose of this study is to develop the models of “pressure loss in the pipeline – hydrotransport velocity” i = f (V) for the “water-coal-fuel oil” mixtures of different compositions, which reflect regularities of the combined process of “hydro-transport – oil agglomeration of coal”. Methods. Physical modelling of the combined process of “hydrotransport – oil

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Ryabokon, E., P. Shatov, N. Gorgol, T. Kamina, and E. Stoyan. "DYNAMICS OF WOUND HEALING AFTER INTRAORAL PIERCING WITH MEDICAL STEEL CLIPS IN EXPERIMENTAL ANIMALS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 19, no. 3 (2019): 156–61. http://dx.doi.org/10.31718/2077-1096.19.3.156.

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Introduction. In modern dentistry, medical steel, along with other materials used for dental implantation, is considered as biocompatible or bio-tolerant materials. Among the commonest complications caused by piercing, there are hypertrophic scarring, pain, swelling and infection. Therefore, the research on clinical and morphological changes in tongue and cheek tissues during experimental piercing with medical steel clips on animals and further evaluation of the consequences of this procedure seem to be quite relevant. The purpose of the study was to determine the effect of clips made of medic

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Peciar, Marian, Roman Fekete, and Peter Peciar. "Agglomeration Technologies of Processing Powder Wastes." Solid State Phenomena 244 (October 2015): 121–29. http://dx.doi.org/10.4028/www.scientific.net/ssp.244.121.

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This article deals with the presentation of modern applications for processing powdered, primarily hazardous, waste to an agglomeration form appropriate for subsequent processing by classical methods, for example in the construction, automotive and consumer goods industries. The aim of the research work was to set appropriate operating conditions in order to appreciate currently non-processable wastes resulting from the intensive production of often extremely expensive materials. Technologies which enable returning powder waste back into the primary production cycle were developed and experime

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Aleksić, Ivana, Teodora Glišić, Slobodanka Ćirin-Varađan, Mihal Djuris, Jelena Djuris, and Jelena Parojčić. "Evaluation of the Potential of Novel Co-Processed Excipients to Enable Direct Compression and Modified Release of Ibuprofen." Pharmaceutics 16, no. 11 (2024): 1473. http://dx.doi.org/10.3390/pharmaceutics16111473.

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Background/Objectives: Improving the production rates of modern tablet presses places ever greater demands on the performance of excipients. Although co-processing has emerged as a promising solution, there is still a lack of directly compressible excipients for modified-release formulations. The aim of the present study was to address this issue by investigating the potential of novel co-processed excipients for the manufacture of modified-release tablets containing ibuprofen. Methods: The excipients were prepared by melt granulation of lactose monohydrate with glyceryl palmitostearate as a b

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Melnyik, G., T. Yarnykh, and M. Buryak. "The substantiation of the choice of a gel former for developing the gel composition with hyaluronic acid and decametoxin." Ukrainian biopharmaceutical journal, no. 1(66) (April 12, 2021): 10–14. http://dx.doi.org/10.24959/ubphj.21.298.

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Topicality. Bedsores are an urgent problem of modern medicine both at the outpatient and inpatient stage. For the treatment of infected bedsores it is advisable to use drugs that have a complex effect focused on various parts of the pathological process. For the treatment of chronic wounds and bedsores together with the inhibition of the growth of microorganisms the drug must provide the optimal conditions for the growth of granulation, have a reparative and anti-inflammatory effect. Aim. To experimentally substantiate the composition of the gel base with hyaluronic acid and decamethoxine. Mat

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Javadinejad, Safieh, Rebwar Dara, and Forough Jafary. "Examining the association between dust and sediment and evaluating the impact of climate change on dust and providing adaptation." Resources Environment and Information Engineering 2, no. 1 (2020): 61–70. http://dx.doi.org/10.25082/reie.2020.01.002.

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In this research, the catchment area of the Karkheh River has been investigated in order to investigate the relationship between the sediment and the effect of climate change on the phenomenon of microstrip. In the first step, to determine the relationship between the grains and sediments, it is necessary to determine the origin of sedimentation and its gradation. Accordingly, some sediment samples were taken from the river bed. Sediment aggregate size measurement is an important tool for studying its origin. Currently, for statistical purposes, many samples are used, but these methods are tim

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Viltsaniuk, O. A., and M. V. Mazur. "JUSTIFICATION OF THE EFFECTIVENESS OF THE USE OF DALMAXIN RECTAL SUPPOSITORIES (THIOTRIAZOLIN) IN THE COMPLEX TREATMENT OF ACUTE PARAPROCTITIS." Kharkiv Surgical School, no. 1 (February 20, 2020): 54–62. http://dx.doi.org/10.37699/2308-7005.1.2020.06.

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Summary. The problem of treatment of acute purulent paraproctitis is one of the most urgent problems of modern coloproctology. Study objective. To evaluate the effectiveness of the use of Dalmaxin rectal suppositories in the complex treatment of acute paraproctitis. Materials and methods. The effectiveness of use of Dalmaxin rectal suppositories was conducted in 62 patients with acute subcutaneous paraproctitis, assigned to two groups, a main group of 30 patients and a comparison group of 32 patients. All patients underwent radical surgery. Antimicrobial, detoxification and symptom

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Чунихин, Андрей, Andrey Chunihin, Эрнест Базикян, and Ernest Bazikyan. "EXPERIMENTAL LOW ENERGY NANOSECOND LASEROTHERAPY AND MICROSURGERY OF MODELING PERIODONTITIS USING MORPHOLOGICAL ANALYSIS." Actual problems in dentistry 15, no. 1 (2019): 80–86. http://dx.doi.org/10.18481/2077-7566-2019-15-1-80-86.

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Background. The problem of the treatment of periodontal disease is acute in modern dentistry. The multiplicity of etipathogenetic factors causing the development of periodontitis, malignations associated with the loss of teeth cause the search for new methods of complex therapy of periodontal diseases, including the inclusion of modern laser technologies. Purpose ― comparative assessment of the effect on the regeneration of periodontal tissues of nanosecond laser radiation with a wavelength of 1265 ± 5 nm of traditional photodynamic therapy using morphological and morphometric analysis i

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Haida, Ya I., K. R. Muradian, S. V. Petrushenko, O. S. Herasymenko, and A. V. Okolets. "EXPERIENCE OF USING NPWT-THERAPY IN THE TREATMENT OF COMBAT INJURIES OF SOFT TISSUES OF THE LIMBS AND BODY." Kharkiv Surgical School, no. 4 (September 20, 2021): 56–60. http://dx.doi.org/10.37699/2308-7005.4.2021.11.

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Summary. Aim. NPWT-therapy (Negative-pressure wound therapy) or VAC-therapy (Vacuum Assisted Clousur) - a modern method of wound healing, which significantly improves the course of all stages of the wound process and is relevant today due to the large number of wounded during hostilities in eastern Ukraine. Often these injuries are combined and lead to the formation of large soft tissue defects. The aim of the study. Improving the results of treatment of the wounded with extensive defects of the soft tissues of the torso and extremities through the use of NPWT therapy. Materials an

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Jeremic, Svetlana, Vladimir Radosavljevic, and Dobrila Jakic-Dimic. "Current bacterial diseases of fresh water fishes." Biotehnologija u stocarstvu 21, no. 3-4 (2005): 141–51. http://dx.doi.org/10.2298/bah0504141j.

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From the beginning of fish cultivation, diseases have appeared as a serious problem in this branch of agriculture. In recent years, by the intensifying of production, fish diseases have become even more significant and complex field. Bacterial diseases are constant threat for fish farming, and because of rapid course and severity of clinical manifestations the represent significant part of fish pathology, and also have great economical importance. Harmful effects of bacterial diseases on fishes are: increased morbidity and mortality rate, decreased feed conversion efficiency, decreased growth

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Kubanov, A. A., A. E. Karamova, V. I. Albanova, and E. S. Monchakovskaya. "Therapy of patients with congenital epidermolysis bullosa using modern non-adherent wound dressings." Vestnik dermatologii i venerologii 95, no. 1 (2019): 30–40. http://dx.doi.org/10.25208/0042-4609-2019-95-1-30-40.

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Aim. To evaluate the clinical efficacy of modern atraumatic non-adherent wound dressings in patients with congenital epidermolysis bullosa. Materials and methods. The study involved 9 patients diagnosed with congenital epidermolysis bullosa (EB), including 7 women and 2 men aged 21–50 years. All the patients underwent immunofluorescent antigenic mapping of skin biopsies to confirm the clinical diagnosis. External therapy using modern atraumatic non-adherent wound dressings was performed in all the patients. The evaluation of the clinical efficacy of the applied therapy was carried out on the 1

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Mitish, V. A., Yu S. Paskhalova, R. P. Terekhova, V. S. Demidova, L. G. Alkhimova, and G. V. Khamidulin. "The place of polyethylene glycol-based ointment containing chloramphenicol in the modern strategy for the treatment of infected wounds and purulent-necrotic lesions." Wounds and wound infections. The prof. B.M. Kostyuchenok journal 11, no. 1 (2024): 28–40. http://dx.doi.org/10.25199/2408-9613-2024-11-1-28-40.

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In the structure of acute surgical pathology, complicated infections of the skin and soft tissues retain their leading positions, accounting for up to 30–40% of all initial visits to the surgeon.Objective: To evaluate the effectiveness (time of transition of wound healing process into reparative phase) and safety of polyethylene glycolbased ointment containing chloramphenicol (Levomekol®) in patients over 18 years of age with complicated infections of the skin and soft tissues.Material and methods. The article presents outcomes of managing 30 patients with complicated infections of the skin an

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Merkulov, D. S., E. Ya Fistal, and V. O. Demchuk. "Applicability of Ultrasonic Cavitation in Complex Treatment of Combat Surgical Trauma." Innovative Medicine of Kuban, no. 2 (April 29, 2024): 64–71. http://dx.doi.org/10.35401/2541-9897-2024-9-2-64-71.

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Background: The history of gunshot wound treatment dates back several centuries. However, every new war or protracted armed conflict makes surgeons return to this issue. In recent years the nature of wounds changed: injuries become more severe, with a larger amount of damaged tissue. Among the wounded persons, blast and fragment injuries prevail over gunshot injuries. Gunshot wounds, as a rule, differ from wounds inflicted by old-style weapons in the scale, depth, and severity of anatomical destruction of soft tissue and bones. Modern physical methods of wound management and preparation of wou

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Golubev, K. V., E. E. Topuzov, V. V. Oleynik, T. R. Stuchevskaya, and S. V. Gorchakov. "General principles for the prevention and treatment of complications of percutaneous endoscopic gastrostomy (review of literature)." Scientific Notes of the Pavlov University 26, no. 3 (2020): 25–30. http://dx.doi.org/10.24884/1607-4181-2019-26-3-25-30.

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We considered the views of researchers presented in the modern literature on both the problem as a whole and discussion questions regarding the causes of development, preventive measures, and methods of treating percutaneous endoscopic gastrostomy complications, such as clogging of the gastrostomy tube, peristomal wound infections, necrotic fasciitis, pneumoperitoneum, buried bumper syndrome, growth of granulations in the gastrostomy zone, postoperative bleeding and intraparietal hematoma of the gastric wall, traumatic dislocation of the gastrostomy tube, peritonitis after percutaneous endosco

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Nadyrov, E. A., V. I. Nikolaev, S. I. Kirilenko, et al. "Morphological and radiological characteristics of experimental bone tissue regeneration." Health and Ecology Issues, no. 3 (October 1, 2021): 94–104. http://dx.doi.org/10.51523/2708-6011.2021-18-3-12.

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Objective. To study the dynamics of reparative bone tissue regeneration in experimental animals using a native transplantation autosmix (NTA).Materials and methods. Male Wistar rats weighing 180–200 g and aged 6–7 months were used. Bone tissue defects were modelled using a cutter with a diameter of 2 mm (experimental group). A similar defect of the middle third of the right tibia was formed in the control group animals without flling the defects with bone tissue. The animals were removed from the experiment on days 3, 7, 14, 30 and 60 of the experiment (per 6 animals for each observation perio

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