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Dissertations / Theses on the topic 'Modern Therapeutics'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Dwyer, P. S. "Use of dextropropoxyphene in modern therapeutics : Efficacy, dependence liability and toxicity of dextropropoxyphene/paracetamol combinations with special reference to epidemiology of self-poisoning by analgesic drugs." Thesis, University of Bradford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234737.

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2

Wong, Muh Geot. "Novel therapeutic options in models of nephropathy." Thesis, The University of Sydney, 2010. https://hdl.handle.net/2123/29159.

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Despite a better understanding of the pathogenesis and progression of chronic kidney disease (CKD), the functional decline of kidney function in patients with any form of nephropathy remains the greatest challenge to clinicians. Renal fibrosis is considered the ‘point of no return’ for any form of chronic kidney disease, including diabetic nephropathy, and renal dysfunction induced by inflammation, hypoxia, reactive oxygen species, and lipotoxicity. However, there are limited therapeutic options to mitigate against kidney fibrosis, and therefore novel agents are required to add to the ar

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3

Al-Gonaiah, Majed A. "Investigating xanthine oxidase toxicity models in cultured cerebellar granule neurons." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1057/.

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In the last few decades, evidence has been accumulating for a role for xanthine oxidoreductase (XOR)-generated toxic reactive oxygen species (ROS) in a variety of pathological conditions that affect different organ systems. This enzyme in mammals exists in two inter-convertible forms: xanthine dehydrogenase (XDH) (the predominant intracellular form under physiological conditions) and xanthine oxidase (XO). A combination of XO and its oxidizable substrate xanthine (X) (or hypoxanthine (HX)) is widely used as a model to produce ROS and to study their effects in a variety of cell culture studies.

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4

Hall, Susan. "Protective Effects of Caffeine and Coffee Constituents in Inflammatory Models of Depression." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366024.

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Caffeine is the most widely used compound that exerts a pharmacological effect on the central nervous system and is found most predominantly in coffee. It has been well established that coffee has a beneficial effect on numerous disease states including depression. A number of prospective and cohort studies have shown the benefit of coffee in preventing episodes of depressive symptoms. Studies indicate that the amount of coffee consumed is important with studies showing that moderate intake of caffeinated coffee may be beneficial in decreasing the risk of developing symptoms of clinical depres

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5

Salazar, Degracia Anna 1991. "Mechanisms of muscle wasting in cachexia models : therapeutic implications." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/666924.

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La caquexia afecta negativamente a los pacientes con enfermedades crónicas y sobre todo en el cáncer. Las estrategias terapéuticas son aún limitadas. Los beta2-agonistas (formoterol) y el soporte nutricional (L-carnitina) pueden atenuar los efectos deletéreos en el músculo. En la presente tesis, el tratamiento con formoterol y L-carnitina indujo efectos beneficiosos (peso corporal y muscular, estructura, apoptosis, proteólisis y vías de señalización) en el diafragma y músculos de las extremidades en un modelo experimental de caquexia cancerosa (hepatoma ascitico Yoshida AH-130, en ratas). En r

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6

Zeng, Haoyang Ph D. Massachusetts Institute of Technology. "Machine learning models for functional genomics and therapeutic design." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122689.

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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2019<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 213-230).<br>Due to the limited size of training data available, machine learning models for biology have remained rudimentary and inaccurate despite the significant advance in machine learning research. With the recent advent

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7

Thote, Tanushree. "Evaluation of therapeutics strategies for osteoarthritis using contrast based CT imaging." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54010.

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Osteoarthritis (OA) affects nearly 27 million people alone and is the leading cause of chronic disability in the US. Current treatment methods target pain relief for OA via non-steroidal anti-inflammatory drugs (NSAIDs) since there are currently no clinically approved disease modifying osteoarthritis drugs (DMOADs) demonstrating efficacy. Despite multiple pre-clinical DMOAD experiments being conducted, the screening rate for drugs is severely limited by the lack of sensitivity of outcome measures and the time consuming process to achieve them. Our lab has previously developed and validated a

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8

Wong, Xing-Wei. "Model-Based Therapeutics for Type 1 Diabetes Mellitus." Thesis, University of Canterbury. Mechanical Engineering, 2008. http://hdl.handle.net/10092/1573.

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The incidence of Type 1 diabetes is growing yearly. Worryingly, the aetiology of the disease is inconclusive. What is known is that the total number of affected individuals, as well as the severity and number of associated complications are growing for this chronic disease. With increasing complications due to severity, length of exposure, and poor control, the disease is beginning to consume an increasingly major portion of healthcare costs to the extent that it poses major economic risks in several nations. Research has shown that intensive insulin therapy aimed at certain minimum glycosylat

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9

Gumucio, Astrid. "Therapeutic and functional studies in animal models of Alzheimer's disease." Doctoral thesis, Uppsala universitet, Geriatrik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223135.

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Senile plaques (Aβ) and neurofibrillary tangles (tau) are pathological hallmarks of Alzheimer’s disease (AD). If and how the formation of these deposits are mechanistically linked remains mainly unknown. In recent years, the focus has shifted from insoluble protein deposits to soluble aggregates of Aβ and tau. Protofibrils are large soluble Aβ oligomers which were linked to AD by the discovery of the Arctic AβPP mutation. Treatment of young tg-ArcSwe mice with an Aβ protofibril-selective antibody, mAb158, cleared protofibrils, prevented amyloid plaque deposition and protected cultured cells fr

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10

Joshi, Gururaj. "MULTIFUNCTIONAL POTENTIAL THERAPEUTICS TOWARDS OXIDATIVE STRESS MEDIATED NEURODEGENERATIVE DISORDERS AND MODELS THEREOF." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/298.

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The studies described in this dissertation were performed with the goal of understandingthe function of antioxidant compounds delivered in vivo to rodents and the implication of theresults towards oxidative stress (OS)-related neurodegenerative disorders with particularemphasis on Alzheimer's disease (AD). OS has been implicated in AD and is characterized byextensive oxidative damage to protein, lipids and DNA. A major thrust of this dissertation workwas to gain insight into antioxidant properties of compounds used in the following studies andtheir efficacy as potential therapeutics for treatm

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11

Kim, Esther S. "New financing and business models to accelerate the development of novel therapeutics." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111315.

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Thesis: S.M. in Technology and Policy, Massachusetts Institute of Technology, School of Engineering, Institute for Data, Systems, and Society, Technology and Policy Program, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 119-125).<br>Many obstacles contribute to the uncertainty and risk associated with early drug development, leading to the "valley of death" in which promising drug candidates experience difficulties in reaching the market. These challenges have serious consequences for patient populations facing significant unmet medical needs. In

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12

McGrath, Michael Anthony. "Development of novel therapeutics and in vitro models for spinal cord injury." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7651/.

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Spinal cord injury (SCI) is a devastating condition, which results from trauma to the cord, resulting in a primary injury response which leads to a secondary injury cascade, causing damage to both glial and neuronal cells. Following trauma, the central nervous system (CNS) fails to regenerate due to a plethora of both intrinsic and extrinsic factors. Unfortunately, these events lead to loss of both motor and sensory function and lifelong disability and care for sufferers of SCI. There have been tremendous advancements made in our understanding of the mechanisms behind axonal regeneration and r

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13

Sanberg, Paul R. "Animal models of neurobehavioral disorders : from toxins to transplants and experimental therapeutics." Thesis, Canberra, ACT : The Australian National University, 1997. http://hdl.handle.net/1885/145709.

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14

Al-Tameemi, Wafaa. "Studying the mechanisms of chemotherapy-induced alopecia and the effect of cooling using in vitro human keratinocyte models." Thesis, University of Huddersfield, 2017. http://eprints.hud.ac.uk/id/eprint/32611/.

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Chemotherapy-induced alopecia (CIA) is widely regarded as the most traumatic side effect associated with cancer treatment and the associated stress can be detrimental to overall outcomes. Yet there has been little research into its pathobiology and no pharmaceutical intervention is available. CIA is caused by chemotherapy-mediated damage of the rapidly dividing cells of the hair follicle and although it is normally reversible, on regrowth the hair is often different in colour and/or texture and only grows gradually. The only effective treatment for CIA currently available is scalp cooling. It

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15

Vaz, Marcela Tatiana Barros. "Unraveling phytochemicals with potential therapeutic application for neurodegeneration." Master's thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier, 2017. http://hdl.handle.net/10362/69938.

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"Epidemiological data suggest that phytochemicals may prevent and even reverse specific pathological processes underlying neurodegenerative diseases. A (poly)phenol-enriched fraction from leaves of Corema album was previously reported to modulate central events related to α-Synuclein expression and aggregation as well as oxidative stress in eukaryotic models of Parkinson’s disease. In order to identify the potentially bioactive compound, this extract was subjected to a bioguided fractionation, leading to the identification of CAL_X.(...)"<br>N/A

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16

Condé, Geraldo Garcez. "A felicidade mediada: um estudo do imaginário da felicidade na mídia." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1838.

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Universidade do Estado do Rio de Janeiro<br>Esta tese é um estudo do imaginário da felicidade no discurso prescritivo/terapêutico de um gênero jornalístico caracterizado por oferecer conselhos, orientações, fórmulas e modelos para a condução da vida em diferentes esferas aqui denominado imprensa conselheira . O objetivo é compreender como daí emerge uma concepção de felicidade cujos aspectos problemáticos seriam abrandados, contrastando com a imagem dessa experiência que emana dos diagnósticos da subjetividade moderna empenhados em denunciar os males da civilização. A partir do exame das im

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17

Gaedtke, Lars. "Cell culture models and novel gene therapeutic strategies for colorectal cancer." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-51714.

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18

Plym, Forshell Linus. "Assessment of therapeutic targets in experimental models of Myc-induced lymphoma." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46534.

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The Myc transcription factor activates expression of genes that promote cellular functions such as proliferation and cell growth. The deregulated Myc expression, characteristic for the tumor cell, also activates apoptosis, which selects for additional genetic changes deactivating the induced cell death. However, the continuous overexpression of Myc can also be a liability for a tumor, which can be taken advantage of in cancer treatment. In Paper I, we describe a new way of using the DNA methyltransferase inhibitor Decitabine, in treating Myc overexpressing tumors. We show that Decitabine trea

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19

Tonelli, Francesca R. "Sphingosine kinases : evaluation of therapeutic potential using prostate cancer cell models." Thesis, University of Strathclyde, 2012. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=18199.

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Sphingosine kinase 1 and 2 (SK1 and SK2) catalyse the formation of the bioactive lipid sphingosine 1-phosphate. Alterations in SK1 function have been implicated in human prostate cancer, being involved in the acquisition of therapy resistance and progression to androgen independence, two major issues in the clinical management of this disease. This study investigated the effect of down-regulating SK1 in androgen-dependent (LNCaP) and androgen-independent (LNCaP-AI) prostate cancer cells. The SK1 inhibitor, 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole (SKi) activates the proteasome by acutel

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20

Witkiewicz, Agnieszka K., Uthra Balaji, Cody Eslinger, et al. "Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer." Cell Press, 2016. http://hdl.handle.net/10150/618060.

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Pancreatic ductal adenocarcinoma (PDAC) harbors the worst prognosis of any common solid tumor, and multiple failed clinical trials indicate therapeutic recalcitrance. Here, we use exome sequencing of patient tumors and find multiple conserved genetic alterations. However, the majority of tumors exhibit no clearly defined therapeutic target. High-throughput drug screens using patient-derived cell lines found rare examples of sensitivity to monotherapy, with most models requiring combination therapy. Using PDX models, we confirmed the effectiveness and selectivity of the identified tr

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21

Witkiewicz, Agnieszka K., Uthra Balaji, Cody Eslinger, et al. "Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer." CELL PRESS, 2016. http://hdl.handle.net/10150/621251.

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Pancreatic ductal adenocarcinoma (PDAC) harbors the worst prognosis of any common solid tumor, and multiple failed clinical trials indicate therapeutic recalcitrance. Here, we use exome sequencing of patient tumors and find multiple conserved genetic alterations. However, the majority of tumors exhibit no clearly defined therapeutic target. High-throughput drug screens using patient-derived cell lines found rare examples of sensitivity to monotherapy, with most models requiring combination therapy. Using PDX models, we confirmed the effectiveness and selectivity of the identified treatment res

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22

Novakovic, Ana M. "Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316562.

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Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. This thesis focuses on development of pharmacometric models for characterization and quantification of the relationships between drug exposure, biomarkers and clinical endpoints in relapse-remitting MS (RRMS) following cladribine trea

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23

Becker, Daniel. "Salmonella as a research model for fundamental insights into therapeutic strategies." Berlin mbv, Mensch-und-Buch-Verl, 2008. http://d-nb.info/994596502/04.

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24

Ljungdahl, Ståhle Ewa. "In vivo and in vitro models for determination of antiviral activity and resistance /." Stockholm, 1997. http://www.kibic.ki.se/ki/diss/971212ljun.html.

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25

Heslop, James. "Investigating novel methods of enhancing in vitro models of drug induced liver injury." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2053229/.

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Drug induced liver injury (DILI) is a major cause of patient morbidity and mortality inferring considerable burdens onto healthcare and pharmaceutical sectors. As a consequence, substantial resources are directed towards triaging potentially dangerous new compounds at all stages of drug development. However, despite these efforts, hepatotoxic compounds remain the greatest cause of post-marketing drug withdrawal. One of the major factors preventing efficacious screening of new compounds is the lack of a truly representative in vitro model of hepatotoxicity. This thesis describes our efforts to

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26

Kennedy, Barbara Cecily. "Healing music and its literary representation in the early modern period." Thesis, University of Sussex, 2012. http://sro.sussex.ac.uk/id/eprint/46975/.

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This interdisciplinary thesis explores how music is used in the art of healing in two distinct ways in the early modern period: namely, through the use of performed music accompanying the healing process itself, and as ‘speculative music', the latter providing a philosophical model for understanding the interplay of music with body, mind and soul. Redefining an existing enquiry in a specific way, my research seeks to enhance an understanding of the construction of a therapeutic modality that revitalizes the ancient belief in the healing powers of music, manifest since antiquity through the cla

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Schreiner, Laura. "Innovative cancer therapeutics based on polymers or biogenic drugs evaluated in murine tumor models." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-156186.

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Cancer is a leading cause of death worldwide. Although several common treatment options exist, there is an urgent need for improved tumor therapeutics. Therefore, we evaluated three innovative anticancer approaches in vivo. These were newly synthesized siRNA polyplexes, novel myxobacterial anticancer compounds, and innovative polymeric melphalan formulations. We evaluated the in vivo characteristics of polymeric bound siRNA. We could demonstrate that the polymer FolA-PEG24-K(Stp4-C)2 is an efficient carrier for targeting siRNA to the folate receptor expressing tumor tissue of mice. Moreover,

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Chacón, Cabrera Alba 1988. "Molecular alterations in muscle wasting and cachexia : therapeutic approaches in animal models." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/458880.

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Cachexia and muscle deconditioning, which are the major comorbidities in patients with chronic diseases including lung cancer (LC), impair disease prognosis. Several biological mechanisms are involved in these two muscle wasting conditions but current treatment options are limited. Hypothesis: the biological mechanisms involved in muscle wasting and dysfunction may differ between muscle deconditioning and LC induced cachexia in mice. We also hypothesized that the profile of molecular events implicated in disuse muscle atrophy and muscle recovery, may be different between early and late phases

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29

Savai, Rajkumar. "Establishment of mouse lung tumor models and development of new therapeutic approaches." Giessen : VVB Laufersweiler, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?idn=980604214.

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30

Fell, Benjamin. "Organotypic human skin disease models for the assessment of novel therapeutic approaches." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24594.

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Comprehensive in vitro modelling of inflammatory human skin conditions is an essential first step in the development and assessment of potential therapeutic approaches. Mouse models or monolayer keratinocyte cultures come with distinct limitations which might be complimented or overcome by the use of human-specific organotypic 3D culture models. Over the course of this thesis, an organotypic culture system, based on patientderived immortalised keratinocyte cell lines on a dermal equivalent collagen 1 gel, was established and used to recapitulate phenotypical features for two hereditary skin di

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31

Patel, Priyanka. "Development of new therapeutic approaches in mouse models of Amyotrophic Lateral Sclerosis." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/25851.

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La sclérose latérale amyotrophique (SLA) est une pathologie neurodégénérative caractérisée par une perte progressive des neurones moteurs et par de l’atrophie musculaire menant à de la paralysie. Bien que plusieurs mécanismes pathologiques aient été élucidés, la SLA reste un mystère médical puisqu’il n’existe toujours pas de traitement efficace. Nous avons développé deux stratégies dans le but de traiter la SLA. La première stratégie fut de cibler la protéine SOD1 mal repliée (chapitre 2) et la deuxième consistait à traiter la neuroinflammation présente dans la maladie (chapitre 3). Dans le ch

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Guo, Anchen, and 郭安臣. "Therapeutic potentials of oligodendrocyte precursors in the animal model of multiple sclerosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46455516.

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Smith, Trevor. "An investigation into the role of the hyperpolarisation-activated cyclic nucleotide-gated on channels in dorsal root ganglion neurons in rat models of chronic inflammatory and neuropathic pain." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/9093/.

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Chronic pain {CP} is a major health problem that affects about 20% of adults worldwide. Unlike acute, physiological pain, which resolves promptly once the painful stimulus is removed, CP can last for months, years or even a lifetime. CP, which includes inflammatory pain {IP} that is associated with both tissue injury and the accompanying inflammation and peripheral neuropathic pain {NP} that is a direct consequence of a lesion or disease affecting the peripheral nervous system {PNS}, often is a constant burden, degrades peoples’ quality of life, and costs billions of pounds. Patients with CP u

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Unni, Elizabeth Jisha. "Development of models to predict medication non-adherence based on a new typology." Diss., University of Iowa, 2008. http://ir.uiowa.edu/etd/10.

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Elhaneid, Mohamed. "Toxicological assessment of graphene based nanomaterials in cell culture models." Thesis, University of Birmingham, 2019. http://etheses.bham.ac.uk//id/eprint/8881/.

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Graphene oxide (GO) and reduced GO (r-GO) nanomaterials exhibit great potential for several biomedical applications. Of foremost importance is to determine any potential health hazards related in their exposure. In this research, we hypothesised that the different material properties evidenced by GO and r-GO would elicit different biological responses. The first objective of this work was to synthesize Go and r-GO and characterize their physiochemical properties. The second aim was to investigate whether the two-distinct surface chemistries of GO and r-GO influenced their biological effect. Th

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Chen, Lei. "The impact of herbal saponins on gut microflora in animal models." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/55.

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Human gut harbors 100 trillion microbial organisms that is intrinsically linked to individual’s health and diseases, including cancer. Food fiber and phytochemicals such as polyphenols are considered as prebiotic-like dietary modifiers. They can influence the gut microbial communities, and in turn to modulate disease outcome and drug responses of the host. Saponins belong to a family of phytochemicals commonly found in many medicinal and edible plants. Herbal saponins have raised keen interest among scientists for their health-promoting effects, but have not been investigated for their potenti

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Waters, Michele. "Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/95912.

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Keratins are fibrous structural proteins found in human hair that have been used to develop bioactive and biocompatible constructs for a wide variety of tissue engineering and healthcare applications. Their ubiquity, capacity for self-assembly, ease of use and versatility in blended materials, and ability to modulate cell behavior and promote tissue ingrowth have made keratins well-suited for the development of regenerative therapies. In particular, keratins have demonstrated bioactivity in both in-vivo and in-vitro studies, by altering immune and stem cell phenotype and function and promoting

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Yang, Xingdong. "Study of Infection, Immunity, Vaccine and Therapeutics Using Gnotobiotic Pig Models of Human Enteric Viruses." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73313.

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With the absence of gut microbiota, gnotobiotic (Gn) pigs are a unique animal model for studying infection and immunity, and evaluating vaccine and therapeutics for human enteric pathogens. Here, we demonstrate Gn pigs as effective large animal models for human enteric viruses, through evaluating human enterovirus 71 (EV71) infection and immunity, and vaccine and therapeutics for human rotavirus (HRV). Gn pigs could be infected via oral or oronasal route, the natural route of infection. Infected pigs developed clinical signs including fever, neurological and respiratory signs, similar to thos

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Bura, S. Andreea. "New animals models to evaluate therapeutic targets for pain, cognitive and eating disorders." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/31821.

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Animal models are crucial to improve the knowledge of the mechanisms underlying the different pathological processes. These models are also excellent tools to facilitate the research of new targets for the treatment of different diseases and to evaluate the benefit/risk ratio of the potential new treatments. We have focussed this research work in the study of a new potential targets for pain, cognitive and eating disorders using new animal models developed in our laboratory. We first investigated the effects of the interaction between cannabinoids and nicotine on cognitive processes and metabo

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40

Thomas, Hilary. "A feasibility study of oncogene transgenic mice as therapeutic models in cytokine research." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264165.

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Yip, J. "Harnessing the heat shock response as a therapeutic approach in models of MND." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1356296/.

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Amyotrophic Lateral Sclerosis (ALS) is an untreatable and fatal neurodegenerative disease that leads to muscle atrophy, paralysis of voluntary muscles and death. ALS is characterized by the selective degeneration of upper and lower motoneurons in the spinal cord, brain stem and motor cortex. The maJority of ALS cases are sporadic, whereas 10 - 20Z of cases have a genetic component and are familial. The causes for most cases of ALS are unknown and the clinical course is highly variable, suggesting that multiple factors underlie the disease mechanism. Recent experimental evidence has illustrated

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Jackson, Joshua D. "Investigating therapeutic strategies in a preclinical model for Alzheimer's disease." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/investigating-therapeutic-strategies-in-a-preclinical-model-for-alzheimeras-disease(47574a22-9623-4c3e-9fa2-bd68a82ffc31).html.

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Alzheimer's disease (AD) is a worldwide, incurable disease, and the most common form of dementia. Numbers of cases are rising, and since its discovery the only approved medications have treated only the symptoms, not the pathological cause. With the cost to society rising, the debilitating nature of the disease and the pressure put on the family members and support network of patients, disease modifying therapies are in dire need. Current models have proven an invaluable tool with which to study certain aspects of the disease and the genetics behind it, however the lack of clinically approved

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Navarro, Romero Alba 1990. "Role and therapeutic potential of the endocannabinoid system in animal models of intellectual disability." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665798.

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Intellectual disability encompasses several neurodevelopmental disorders characterized by impairments in cognitive and adaptive functioning with onset during the developmental period. Currently, treatment of intellectual disability is restricted to early intervention programs and individualized education, which have limited efficacy. Several preclinical studies indicate that intellectual disability may be improved by pharmacological interventions. This thesis is focused on the role and therapeutic potential of the endocannabinoid system in intellectual disability disorders. The relevance of th

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Forsey, Richard. "Development of cartilage damage models for a tribological investigation of therapeutic lubricants in osteoarthritis." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411310.

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Albtoush, Nansy. "Inhibiting the Function of TSG-6 in Inflammatory Models as a Possible Therapeutic Intervention." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1544060182841309.

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Lui, Sing-leung, and 雷聲亮. "Therapeutic potential of rapamycin in renal parenchymal diseases: insights from murine models of lupusnephritis, adriamycin nephropathy and renal ischemia reperfusioninjury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41291013.

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Xiao, Jia, and 肖佳. "Protective mechanisms of garlic and wolfberry derivatives on acute and chronic liver injury animal models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/193039.

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Liver is one of the most important organs in the body that maintains the homeostasis of metabolism, immunity, detoxification and hematopoiesis. A large number of acute and chronic intoxications and diseases can influence the normal functions of the liver, leading to irreversible liver damage and even cancer. Currently, applying herbs or herbal derivatives in the prevention and therapy of acute and chronic liver injury receive numerous attentions since they hold great potentials as food supplements in the treatment strategy of liver injuries. There were two major hypotheses of this current work

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Kia, Richard. "Novel approaches using human induced pluripotent stem cells and microRNAs in the development of relevant human hepatocyte models for drug-induced liver injury." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2010059/.

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Drug-induced liver injury (DILI) remains a prominent cause of patient morbidity and mortality, partly due to the lack of relevant in vitro hepatic models for accurate screening for drug-induced hepatotoxicity at the early stages of drug development, and also the lack of sophisticated in vitro model systems to mechanistically understand the pathways that are perturbed following drug exposure. This thesis describes our endeavour to develop more relevant in vitro human hepatocyte models via novel investigative approaches using insights gained from the rapidly advancing research areas of human ind

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Keet, Lana. "Development of in vitro models to investigate the anti-inflammatory properties of Cyclopia Maculata and other South African herbal teas : a comparative study." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/97030.

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Thesis (MSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: Chronic inflammation is suggested to contribute to cancer development and therefore a potential target for chemoprevention. In the skin, keratinocytes and macrophages play an integral part in acute and chronic inflammation, with interleukin 1-α (IL-1α) and tumor necrosis factor α (TNF-α) as key cytokines governing this process. Green tea (Camellia sinensis) and the South African herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) displayed antiinflammatory effects in mouse and human skin. To further in

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Woodruff, Trent M. "Therapeutic activity of a novel C5a receptor antagonist in inflammatory models of disease in rats /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17436.pdf.

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