Log in

Relevant bibliographies by topics / Modified herpes virus / Journal articles

To see the other types of publications on this topic, follow the link: Modified herpes virus.

Journal articles on the topic 'Modified herpes virus'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Modified herpes virus.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Rybalko, S., N. Nesterova, S. Diadiun, et al. "Therapeutical effect of modified adamantane copolymer compounds: study of molecular mechanisms." Acta Biochimica Polonica 48, no. 1 (2001): 241–49. http://dx.doi.org/10.18388/abp.2001_5132.

Full text

Abstract:

Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other

APA, Harvard, Vancouver, ISO, and other styles

2

Kibuule, Grace N., Jay M. Truitt, and Michelle Tarbox. "Modified Tzanck Smear to Evaluate for Herpes Simplex Virus." Journal of Drugs in Dermatology 22, no. 12 (2023): e38-e39. http://dx.doi.org/10.36849/jdd.4763.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Nandi, S., Manoj Kumar, M. Manohar, and R. S. Chauhan. "Bovine herpes virus infections in cattle." Animal Health Research Reviews 10, no. 1 (2009): 85–98. http://dx.doi.org/10.1017/s1466252309990028.

Full text

Abstract:

AbstractBovine herpes virus 1 (BHV-1) is primarily associated with clinical syndromes such as rhinotracheitis, pustular vulvovaginitis and balanoposthitis, abortion, infertility, conjunctivitis and encephalitis in bovine species. The main sources of infection are the nasal exudates and the respiratory droplets, genital secretions, semen, fetal fluids and tissues. The BHV-1 virus can become latent following a primary infection with a field isolate or vaccination with an attenuated strain. The viral genomic DNA has been demonstrated in the sensory ganglia of the trigeminal nerve in infectious bo

APA, Harvard, Vancouver, ISO, and other styles

4

Samson, Kurt. "Modified Herpes Virus Shows Promise in High-Grade Pediatric Glioma." Oncology Times 43, no. 11 (2021): 45. http://dx.doi.org/10.1097/01.cot.0000754732.62026.79.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Chen, Liting, Chen Xu, Hainan Xu, et al. "RVG29-modified oncolytic herpes simplex virus for intracranial tumor treatment." Nano Today 61 (April 2025): 102573. https://doi.org/10.1016/j.nantod.2024.102573.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Bultmann, Hermann, James S. Busse, and Curtis R. Brandt. "Modified FGF4 Signal Peptide Inhibits Entry of Herpes Simplex Virus Type 1." Journal of Virology 75, no. 6 (2001): 2634–45. http://dx.doi.org/10.1128/jvi.75.6.2634-2645.2001.

Full text

Abstract:

ABSTRACT Entry of herpes simplex virus type 1 (HSV-1) into host cells occurs through fusion of the viral envelope with the plasma membrane and involves complex and poorly understood interactions between several viral and cellular proteins. One strategy for dissecting the function of this fusion machine is through the use of specific inhibitors. We identified a peptide with antiviral activity that blocks HSV-1 infection at the entry stage and during cell-to-cell spreading. This peptide (called EB for “entry blocker”) consists of the FGF4 signal sequence with an RRKK tetramer at the amino termin

APA, Harvard, Vancouver, ISO, and other styles

7

Jones, Samuel T., Valeria Cagno, Matej Janeček, et al. "Modified cyclodextrins as broad-spectrum antivirals." Science Advances 6, no. 5 (2020): eaax9318. http://dx.doi.org/10.1126/sciadv.aax9318.

Full text

Abstract:

Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed nontoxic, broad-spectrum virucidal gold nanoparticles. Here, we develop further the concept and describe cyclodextrins, modified with mercaptoundecane sulfonic acids, to mimic heparan sulfates and to provide the key nontoxic virucidal action. We show that the resulting macromolecules are broad-spectrum, biocompatible, and virucidal at micromol

APA, Harvard, Vancouver, ISO, and other styles

8

Barton, S. E., P. E. Munday, and R. J. Patel. "Asymptomatic shedding of herpes simplex virus from the genital tract: uncertainty and its consequences for patient management." International Journal of STD & AIDS 7, no. 4 (1996): 229–32. http://dx.doi.org/10.1258/0956462961917799.

Full text

Abstract:

A frequent component of the management of patients with genital herpes concerns the possibility of asymptomatic shedding and potential sexual transmission of the virus. Approaches intended to provide supportive counselling and reassurance of patients about these issues need now to be modified in the light of increasing data of the frequency of asymptomatic detection of virus and the effects of antiviral therapy on this phenomenon. Further studies to delineate the relationship between asymptomatic detection of HSV in the genital tract and the mechanism of sexual transmission of this virus need

APA, Harvard, Vancouver, ISO, and other styles

9

Zahornyi, M. M., O. M. Lavrynenko, O. Yu Pavlenko, et al. "The antiviral activity of cerium and lanthanum nanooxides modified with silver." Himia, Fizika ta Tehnologia Poverhni 14, no. 2 (2023): 262–72. http://dx.doi.org/10.15407/hftp14.02.262.

Full text

Abstract:

Today, the antiviral activity of oxide nanomaterials can be used in the fight against the viral disease COVID-19. It is thought that Ag nanoparticles may bind to the surface glycoprotein of the virus and interfere with the virus’s interaction with epithelial cells, and inhibit virus reproduction by releasing silver ions in the cell. The viruses’ inhibition with RNA (ribonucleic acid) and DNA (deoxyribonucleic acid) genomes by oxide nanocomposites action was presented. In this research, the surface structure of doped CeO2 (La2O3) was studied by nitrogen adsorption-desorption based on BET method

APA, Harvard, Vancouver, ISO, and other styles

10

Liu, XueQiao, Eeva Broberg, Daisuke Watanabe, Timothy Dudek, Neal DeLuca, and David M. Knipe. "Genetic engineering of a modified herpes simplex virus 1 vaccine vector." Vaccine 27, no. 21 (2009): 2760–67. http://dx.doi.org/10.1016/j.vaccine.2009.03.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Sudo, K., K. Konno, S. Shigeta, and T. Yokota. "Inhibitory Effects of Podophyllotoxin Derivatives on Herpes Simplex Virus Replication." Antiviral Chemistry and Chemotherapy 9, no. 3 (1998): 263–67. http://dx.doi.org/10.1177/095632029800900307.

Full text

Abstract:

Podophyllotoxin and its derivatives were examined for inhibitory effects on the replication of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), including acyclovir-resistant virus and clinical isolates. Deoxypodophyllotoxin (RD4–6266) proved to be a highly potent and selective inhibitor of all HSV strains in MRC-5 cells. EC50 values of RD4–6283 (in which the methylenedioxy ring A is modified) for HSV-1 and -2 were inferior to those of deoxypodophyllotoxin. However, podorhizol (RD4–6277) and 5′-methoxy-podorhizol (RD4–6276), in which ring C is absent, did notinhibit HSV replication. Moreov

APA, Harvard, Vancouver, ISO, and other styles

12

Preda, Madalina, Loredana Sabina Cornelia Manolescu, and Razvan Daniel Chivu. "Advances in Alpha Herpes Viruses Vaccines for Human." Vaccines 11, no. 6 (2023): 1094. http://dx.doi.org/10.3390/vaccines11061094.

Full text

Abstract:

Alpha herpes simplex viruses are an important public health problem affecting all age groups. It can produce from common cold sores and chicken pox to severe conditions like encephalitis or newborn mortality. Although all three subtypes of alpha herpes viruses have a similar structure, the produced pathology differs, and at the same time, the available prevention measures, such as vaccination. While there is an available and efficient vaccine for the varicella-zoster virus, for herpes simplex virus 1 and 2, after multiple approaches from trivalent subunit vaccine to next-generation live-attenu

APA, Harvard, Vancouver, ISO, and other styles

13

Soares-Ishigaki, Ellen Cristina Siqueira, Maysa Luchesi Cera, Alexandre Pieri, and Karin Zazo Ortiz. "Aphasia and herpes virus encephalitis: a case study." Sao Paulo Medical Journal 130, no. 5 (2012): 336–41. http://dx.doi.org/10.1590/s1516-31802012000500011.

Full text

Abstract:

CONTEXT: Meningoencephalitis early in life, of any etiology, is a risk factor for development of subsequent sequelae, which may be of physical, psychiatric, behavioral or cognitive origin. Anomia is a language abnormality frequently found in such cases, and other language deficits are rarely described. The aim of this study was to describe the cognitive and linguistic manifestations following a case of herpetic meningoencephalitis in a 13-year-old patient with eight years of schooling. CASE REPORT: The patient underwent a speech-language audiology assessment nine months after the neurological

APA, Harvard, Vancouver, ISO, and other styles

14

WILSON, LAWRENCE A., JAMES J. THOMPSON, SUSUMU OHKAWA, and DAVID W. SCOTT. "Characterization of "Modified-Self"-Induced Specific Antibody Hyporesponsiveness to Herpes Simplex Virus." Viral Immunology 5, no. 2 (1992): 113–22. http://dx.doi.org/10.1089/vim.1992.5.113.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Mese, Kemal, Oskar Bunz, Wolfram Volkwein, et al. "Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of Viruses." International Journal of Molecular Sciences 22, no. 18 (2021): 10075. http://dx.doi.org/10.3390/ijms221810075.

Full text

Abstract:

Previous studies reported on the broad-spectrum antiviral function of heparin. Here we investigated the antiviral function of magnesium-modified heparin and found that modified heparin displayed a significantly enhanced antiviral function against human adenovirus (HAdV) in immortalized and primary cells. Nuclear magnetic resonance analyses revealed a conformational change of heparin when complexed with magnesium. To broadly explore this discovery, we tested the antiviral function of modified heparin against herpes simplex virus type 1 (HSV-1) and found that the replication of HSV-1 was even fu

APA, Harvard, Vancouver, ISO, and other styles

16

Orłowski, Piotr, Andrzej Kowalczyk, Emilia Tomaszewska, et al. "Antiviral Activity of Tannic Acid Modified Silver Nanoparticles: Potential to Activate Immune Response in Herpes Genitalis." Viruses 10, no. 10 (2018): 524. http://dx.doi.org/10.3390/v10100524.

Full text

Abstract:

(1) Background: Tannic acid is a plant-derived polyphenol showing antiviral activity mainly because of an interference with the viral adsorption. In this work, we tested whether the modification of silver nanoparticles with tannic acid (TA-AgNPs) can provide a microbicide with additional adjuvant properties to treat genital herpes infection. (2) Methods: The mouse model of the vaginal herpes simplex virus 2 (HSV-2) infection was used to test immune responses after treatment of the primary infection with TA-AgNPs, and later, after a re-challenge with the virus. (3) Results: The mice treated int

APA, Harvard, Vancouver, ISO, and other styles

17

kabilan, Anirudha, Lakshmi Lakshmi, and Pavithra Priyadarshoni S. "Potential of Genetically- Modified Measles Virus as A Treatment Modality For Carcinoma: A Review." Biomedical and Pharmacology Journal 11, no. 2 (2018): 917–22. http://dx.doi.org/10.13005/bpj/1448.

Full text

Abstract:

Malignancy is a disease in which cell division is uncontrolled and prognosis is often poor. Despite recent advances in the felid of medicine the life expectancy after the diagnosis of advanced stages of cancers has high mortality rates . The traditional methods of treatment have low curative effects and high risk of side effects. Further the possibility of re-occurrence is not completely eliminated by any of the conventional methods of treatment. Thus, a technique that affects only the tumour cells without leaving behind any cancer initiator cells must be deviced. Recently genetically modified

APA, Harvard, Vancouver, ISO, and other styles

18

Cinatl Jr, J., J. Cinatl, H. Rabenau, B. Kornhuber, and W. H. Doerr. "HeLa Cells Grown Continuously in Protein-Free Medium: A Novel Model for the Study of Virus Replication." Intervirology 33, no. 1 (1992): 41–48. http://dx.doi.org/10.1159/000150229.

Full text

Abstract:

Human carcinoma of the cervix cell line HeLa, adapted to continuous growth in a protein-free chemically defined medium, was used as substrate for the replication of several human pathogenic viruses. Growth characteristics of the cells designated as HeLa-PF in protein-free 1:1 nutrient mixture of Dulbecco’s modified MEM and Ham’s F-12 supplemented with L-ascorbic acid 2-phosphate were similar to those of the cells grown in a serum-supplemented medium. After 30 months (135 subcultures) in the protein-free medium, HeLa-PF cells were infected with poliovirus types 1, 2 and 3; adenovirus types 2 an

APA, Harvard, Vancouver, ISO, and other styles

19

Stavropoulos, Tom A., and Craig A. Strathdee. "An Enhanced Packaging System for Helper-Dependent Herpes Simplex Virus Vectors." Journal of Virology 72, no. 9 (1998): 7137–43. http://dx.doi.org/10.1128/jvi.72.9.7137-7143.1998.

Full text

Abstract:

ABSTRACT Helper-dependent herpes simplex virus (HSV) vectors (amplicons) show considerable promise to provide for long-term transduced-gene expression in most cell types. The current packaging system of choice for these vectors involves cotransfection with a set of five overlapping cosmids that encode the full HSV type 1 (HSV-1) helper virus genome from which the packaging (pac) elements have been deleted. Although both the helper virus and the HSV amplicon can replicate, only the latter is packaged into infectious viral particles. Since the titers obtained are too low for practical applicatio

APA, Harvard, Vancouver, ISO, and other styles

20

McGovern, Alice E., Nicholas Davis-Poynter, Joanna Rakoczy, Simon Phipps, David G. Simmons, and Stuart B. Mazzone. "Anterograde neuronal circuit tracing using a genetically modified herpes simplex virus expressing EGFP." Journal of Neuroscience Methods 209, no. 1 (2012): 158–67. http://dx.doi.org/10.1016/j.jneumeth.2012.05.035.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Sandler, Vladislav M., Samuel Wang, Kamilla Angelo, Helen G. Lo, Xandra O. Breakefield, and David E. Clapham. "Modified herpes simplex virus delivery of enhanced GFP into the central nervous system." Journal of Neuroscience Methods 121, no. 2 (2002): 211–19. http://dx.doi.org/10.1016/s0165-0270(02)00262-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Tiwari, Vaibhav, Christopher O'Donnell, Ronald J. Copeland, Tanya Scarlett, Jian Liu, and Deepak Shukla. "Soluble 3-O-sulfated heparan sulfate can trigger herpes simplex virus type 1 entry into resistant Chinese hamster ovary (CHO-K1) cells." Journal of General Virology 88, no. 4 (2007): 1075–79. http://dx.doi.org/10.1099/vir.0.82476-0.

Full text

Abstract:

Herpes simplex virus type 1 (HSV-1) interaction with glycoprotein D (gD) receptors facilitates virus entry into cells. Chinese hamster ovary (CHO-K1) cells lacking cellular receptors allow virus to attach, but not to enter, implying a role for receptors during the post-attachment (entry) phase of HSV-1 infection. Here, it is shown that the presence of soluble heparan sulfate (HS) modified by 3-O-sulfotransferase-3 (3-OST-3), but not by 3-OST-1, triggered HSV-1 entry into resistant CHO-K1 cells. It was further demonstrated that a CHO-K1 mutant deficient in glycosaminoglycan synthesis became sus

APA, Harvard, Vancouver, ISO, and other styles

23

Bailey, Daniel, and Peter O’Hare. "Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease." Journal of General Virology 83, no. 12 (2002): 2951–64. http://dx.doi.org/10.1099/0022-1317-83-12-2951.

Full text

Abstract:

Early during infection, the herpes simplex regulatory protein ICP0 promotes the proteasome-dependent degradation of a number of cellular proteins and the loss of a number of SUMO-1-modified protein isoforms, including PML. Recently, ICP0 has been shown to induce the accumulation of conjugated ubiquitin and function as a ubiquitin E3 ligase. However, certain aspects of the biochemistry, cell biology and the links between SUMO-1 conjugation/deconjugation and protein degradation remain unclear. For example, it is not currently known whether SUMO-1 deconjugation is a prerequisite for ubiquitinatio

APA, Harvard, Vancouver, ISO, and other styles

24

Cieślak, Małgorzata, Dorota Kowalczyk, Małgorzata Krzyżowska, Martyna Janicka, Ewa Witczak, and Irena Kamińska. "Effect of Cu Modified Textile Structures on Antibacterial and Antiviral Protection." Materials 15, no. 17 (2022): 6164. http://dx.doi.org/10.3390/ma15176164.

Full text

Abstract:

Textile structures with various bioactive and functional properties are used in many areas of medicine, special clothing, interior textiles, technical goods, etc. We investigated the effect of two different textile woven structures made of 90% polyester with 10% polyamide (PET) and 100% cotton (CO) modified by magnetron sputtering with copper (Cu) on bioactive properties against Gram-positive and Gram-negative bacteria and four viruses and also on the some comfort parameters. PET/Cu and CO/Cu fabrics have strong antibacterial activity against Staphylococcus aureus and Klebsiella pneumonia. CO/

APA, Harvard, Vancouver, ISO, and other styles

25

Advani, Sunil J., Lizette O. Durand, Ralph R. Weichselbaum, and Bernard Roizman. "Oct-1 Is Posttranslationally Modified and Exhibits Reduced Capacity To Bind Cognate Sites at Late Times after Infection with Herpes Simplex Virus 1." Journal of Virology 77, no. 22 (2003): 11927–32. http://dx.doi.org/10.1128/jvi.77.22.11927-11932.2003.

Full text

Abstract:

ABSTRACT In herpes simplex virus 1-infected cells, a high level of α gene expression requires the transactivation of the genes by a complex containing the viral α transinducing factor (αTIF) and two cellular proteins. The latter two, HCF-1 and octamer binding protein Oct-1, are transcriptional factors regulated in a cell cycle-dependent manner. αTIF is a protein made late in infection but packaged with the virion to transactivate viral genes in newly infected cells. In light of the accumulation of large amounts of αTIF, the absence of α gene expression late in infection suggested the possibili

APA, Harvard, Vancouver, ISO, and other styles

26

Neuwelt, Edward A., Michael A. Pagel, and Richard D. Dix. "Delivery of ultraviolet-inactivated 35S-herpesvirus across an osmotically modified blood-brain barrier." Journal of Neurosurgery 74, no. 3 (1991): 475–79. http://dx.doi.org/10.3171/jns.1991.74.3.0475.

Full text

Abstract:

✓ The present studies were undertaken to determine if viral particles can be delivered across the rat blood-brain barrier (BBB). Osmotic BBB modification with intracarotid mannitol (25%) was immediately followed by bolus intracarotid administration of 0.5 ml purified, ultraviolet-inactivated, herpes simplex virus type 1 endogenously labeled with 35S-labeled methionine (2.0 × 106 cpm, approximately 5 × 108 plaque-forming units/ml). After 60 minutes, intravascular virus was cleared by saline perfusion and the animals were sacrificed. A marked increase (fourfold, p ≤ 0.02) in radioactivity was ob

APA, Harvard, Vancouver, ISO, and other styles

27

Patel, Shivani N., Sandra D. Adams, and Lee H. Lee. "Inhibition of Herpes Simplex Virus-1 by the Modified Green Tea Polyphenol EGCG-Stearate." Advances in Bioscience and Biotechnology 09, no. 12 (2018): 679–90. http://dx.doi.org/10.4236/abb.2018.912046.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Lee, J. "G207, modified herpes simplex virus type 1, kills human pancreatic cancer cells in vitro." Journal of Gastrointestinal Surgery 3, no. 2 (1999): 127–33. http://dx.doi.org/10.1016/s1091-255x(99)80021-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Mathew, Shomita S., Megan P. Della Selva, and April D. Burch. "Modification and Reorganization of the Cytoprotective Cellular Chaperone Hsp27 during Herpes Simplex Virus Type 1 Infection." Journal of Virology 83, no. 18 (2009): 9304–12. http://dx.doi.org/10.1128/jvi.01826-08.

Full text

Abstract:

ABSTRACT Chaperone-enriched domains are formed in the nuclei of cells lytically infected with herpes simplex virus type 1 (HSV-1). These domains, called VICE, for virus induced chaperone enriched, contain Hsc70, Hsp70, Hsp40, Hsp90, polyubiquitinated proteins, and components of the proteasome machinery. Accumulating evidence indicates that these sites may be utilized during infection to sequester misfolded, modified, or otherwise unwanted proteins away from viral replication compartments, sites of robust transcription, DNA synthesis, and capsid maturation. To further explore the role of cellul

APA, Harvard, Vancouver, ISO, and other styles

30

Ishov, A. M., and G. G. Maul. "The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition." Journal of Cell Biology 134, no. 4 (1996): 815–26. http://dx.doi.org/10.1083/jcb.134.4.815.

Full text

Abstract:

After DNA viruses enter the nucleus, they initiate a transcriptional cascade which is followed by replication. We investigated whether these processes take place at specific nuclear sites or, as suggested by the mode of entry, randomly throughout the nucleus. Three distinct nuclear domains, nuclear factor-1 sites, coiled bodies, and nuclear domain 10 (ND10), were used as markers to investigate the relative position of DNA virus replication sites. We found that all three nuclear domains had a very high spatial correlation with each other in uninfected cells. After adenoviral infection, nuclear

APA, Harvard, Vancouver, ISO, and other styles

31

Wyand, Michael S., Kelledy H. Manson, Christopher J. Miller та A. Robert Neurath. "Effect of 3-Hydroxyphthaloyl-β-Lactoglobulin on Vaginal Transmission of Simian Immunodeficiency Virus in Rhesus Monkeys". Antimicrobial Agents and Chemotherapy 43, № 4 (1999): 978–80. http://dx.doi.org/10.1128/aac.43.4.978.

Full text

Abstract:

ABSTRACTHeterosexual transmission of human immunodeficiency virus type 1 (HIV-1) is the major cause of the ongoing AIDS epidemic. Application of chemical barrier methods is expected to contribute to the worldwide control of this epidemic. Bovine β-lactoglobulin modified by 3-hydroxyphthalic anhydride (3-hydroxyphthaloyl-β-lactoglobulin [3HP-β-LG]) was shown to inhibit HIV-1, HIV-2, simian immunodeficiency virus (SIV), herpes simplex virus type 1 and 2, andChlamydia trachomatisinfection in vitro. Here, we show that 3HP-β-LG not formulated into any vehicle protected three of six rhesus monkeys a

APA, Harvard, Vancouver, ISO, and other styles

32

Yao, Feng, Nao Murakami, Oliver Bleiziffer, et al. "Development of a Regulatable Oncolytic Herpes Simplex Virus Type 1 Recombinant Virus for Tumor Therapy." Journal of Virology 84, no. 16 (2010): 8163–71. http://dx.doi.org/10.1128/jvi.00059-10.

Full text

Abstract:

ABSTRACT Oncolytic viruses are genetically modified viruses that preferentially replicate in host cancer cells, leading to the production of new viruses and, ultimately, cell death. Currently, no oncolytic viruses that are able to kill only tumor cells while leaving normal cells intact are available. Using T-REx (Invitrogen, Carlsbad, CA) gene switch technology and a self-cleaving ribozyme, we have constructed a novel oncolytic HSV-1 recombinant, KTR27, whose replication can be tightly controlled and regulated by tetracycline in a dose-dependent manner. Infection of normal replicating cells as

APA, Harvard, Vancouver, ISO, and other styles

33

Kasthuri, Mahesh, Chengwei Li, Kiran Verma та ін. "Synthesis of 4′-Substituted-2′-Deoxy-2′-α-Fluoro Nucleoside Analogs as Potential Antiviral Agents". Molecules 25, № 6 (2020): 1258. http://dx.doi.org/10.3390/molecules25061258.

Full text

Abstract:

Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies. ALS-8176, a prodrug of the 4′-chloromethyl-2′-deoxy-2′-fluoro nucleoside ALS-8112, was evaluated in hospitalized infants for the treatment of respiratory syncytial virus (RSV), but was abandoned for unclear reasons. Based on the structure of ALS-8112, a series of novel 4′-modified-2′-deoxy-2′-fluoro nucleosides were synthesized. Newly prepared compounds were evaluated against RSV, but also against a panel of RNA viruses, including Dengue

APA, Harvard, Vancouver, ISO, and other styles

34

Meckes, David G., and John W. Wills. "Dynamic Interactions of the UL16 Tegument Protein with the Capsid of Herpes Simplex Virus." Journal of Virology 81, no. 23 (2007): 13028–36. http://dx.doi.org/10.1128/jvi.01306-07.

Full text

Abstract:

ABSTRACT The UL16 tegument protein of herpes simplex virus is conserved throughout the herpesvirus family. It has been reported to be capsid associated and may be involved in budding by providing an interaction with the membrane-bound UL11 protein. UL16 has been shown to be present in all the major locations that capsids are found (i.e., the nucleus, cytoplasm, and virions), but whether it is actually capsid associated in each of these has not been reported. Therefore, capsids were purified from each compartment, and it was found that UL16 was present on cytoplasmic but not nuclear capsids. In

APA, Harvard, Vancouver, ISO, and other styles

35

Neroev, V. V., L. A. Katargina, L. A. Kovaleva, G. I. Krichevskaya, N. V. Balatskaya, and I. G. Kulikova. "Central bacterial corneal ulcers of prolonged course. Immunological aspects and tactics of etiopathogenetic treatment." Russian Ophthalmological Journal 12, no. 1 (2019): 43–49. http://dx.doi.org/10.21516/2072-0076-2019-12-1-43-49.

Full text

Abstract:

Purpose: to describe the characteristic clinical signs and to study the causes of the development of an unfavorable prolonged course of bacterial corneal ulcers of central localization, and to improve treatment effectiveness. Material and methods. A total of 289 patients with central bacterial corneal ulcers were examined. Two types courses of bacterial corneal ulcer were distinguished: favorable (acute and subacute) and unfavorable (prolonged subacute and prolonged chronic forms). Blood (122 samples) and scrapings from corneal ulcers (110 samples) were examined in a nested polymerase chain re

APA, Harvard, Vancouver, ISO, and other styles

36

Hernandez Bronchud, M., S. Webb, and M. M. Esiri. "Brain blotting: a method to detect multiple DNA copies in specific brain regions." Journal of Histochemistry & Cytochemistry 36, no. 9 (1988): 1191–95. http://dx.doi.org/10.1177/36.9.3403969.

Full text

Abstract:

We developed a method to detect multiple DNA copies (both cellular and viral) in specific brain regions by blotting thick frozen sections onto nylon membranes. This was achieved by "printing" the frozen sections on standard blotting paper immediately after cryotome sectioning and performing blotting according to the standard Southern technique. A "replica" of the blotted section was obtained by keeping on the glass slide the next frozen section cut, which was then stained for conventional histopathological analysis and the cell nuclei counted to give an estimate of the total amount of DNA pres

APA, Harvard, Vancouver, ISO, and other styles

37

Malik, Shiza, Ranjit Sah, Omar Ahsan, Khalid Muhammad, and Yasir Waheed. "Insights into the Novel Therapeutics and Vaccines against Herpes Simplex Virus." Vaccines 11, no. 2 (2023): 325. http://dx.doi.org/10.3390/vaccines11020325.

Full text

Abstract:

Herpes simplex virus (HSV) is a great concern of the global health community due to its linked infection of inconspicuous nature and resultant serious medical consequences. Seropositive patients may develop ocular disease or genital herpes as characteristic infectious outcomes. Moreover, the infectious nature of HSV is so complex that the available therapeutic options have been modified in certain ways to cure it. However, no permanent and highly effective cure has been discovered. This review generates insights into the available prophylactic and therapeutic interventions against HSV. A metho

APA, Harvard, Vancouver, ISO, and other styles

38

Daruish, Maged, Sophie Papa, Jenny L. C. Geh, and Catherine M. Stefanato. "Papulonodular pigmented lesions in a patient with Stage IV malignant melanoma." Clinical and Experimental Dermatology 48, no. 1 (2022): 57–59. http://dx.doi.org/10.1093/ced/llac002.

Full text

Abstract:

A 78-year-old man received immunotherapy for in-transit metastatic melanoma papulonodules on his left lower abdomen in the form of intralesional injections of talimogene laherparepvec (T-VEC), an oncolytic genetically modified herpes virus. Despite therapy, the colour and size of the lesions remained clinically unchanged; however, histopathological examination revealed only melanophages in the absence of melanoma cells. The diagnosis of tumoral melanosis secondary to immunotherapy with T-VEC was made. This case emphasizes the importance of histopathological evaluation in assessing response to

APA, Harvard, Vancouver, ISO, and other styles

39

Pomeranz, Lisa E., and John A. Blaho. "Modified VP22 Localizes to the Cell Nucleus during Synchronized Herpes Simplex Virus Type 1 Infection." Journal of Virology 73, no. 8 (1999): 6769–81. http://dx.doi.org/10.1128/jvi.73.8.6769-6781.1999.

Full text

Abstract:

ABSTRACT The UL49 gene product (VP22) of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) is a virion phosphoprotein which accumulates inside infected cells at late stages of infection. We previously (J. A. Blaho, C. Mitchell, and B. Roizman, J. Biol. Chem. 269:17401–17410, 1994) discovered that the form of VP22 packaged into infectious virions differed from VP22 extracted from infected-cell nuclei in that the virion-associated form had a higher electrophoretic mobility in denaturing gels. Based on these results, we proposed that VP22 in virions was “undermodified” in some way. The goal of

APA, Harvard, Vancouver, ISO, and other styles

40

Orlowski, Piotr, Emilia Tomaszewska, Marianna Gniadek, et al. "Tannic Acid Modified Silver Nanoparticles Show Antiviral Activity in Herpes Simplex Virus Type 2 Infection." PLoS ONE 9, no. 8 (2014): e104113. http://dx.doi.org/10.1371/journal.pone.0104113.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Vrionis, Fotios D., Julian K. Wu, Peimin Qi, William Cano, and Van Cherington. "A more potent bystander cytocidal effect elicited by tumor cells expressing the herpes simplex virus—thymidine kinase gene than by fibroblast virus—producer cells in vitro." Journal of Neurosurgery 83, no. 4 (1995): 698–704. http://dx.doi.org/10.3171/jns.1995.83.4.0698.

Full text

Abstract:

✓ Retrovirus-mediated herpes simplex virus—thymidine kinase (HSV-tk) gene therapy is a promising approach in the treatment of brain tumors. Previous in vitro and in vivo studies have demonstrated a bystander effect in which nonmodified tumor cells in proximity to HSV-tk—modified tumor cells are killed with the modified cells in the presence of ganciclovir. In the present study the authors assessed the contribution of infectious HSV-tk retrovirus made by producer cells to the bystander cytocidal effect in tissue culture using Walker 256 rat breast carcinosarcoma cells, which represent an establ

APA, Harvard, Vancouver, ISO, and other styles

42

Dardick, Joseph, Kayla Weiss, Regy Lukose, Brian Weinrick, Betsy Herold та William R. Jacobs. "A novel vaccine vector: herpes simplex virus type-2 deleted in glycoprotein D (HSV-2 ΔgD) and expressing modified influenza A (IAV) hemagglutinin (HA) antigens". Journal of Immunology 198, № 1_Supplement (2017): 147.9. http://dx.doi.org/10.4049/jimmunol.198.supp.147.9.

Full text

Abstract:

Abstract Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) cause significant global morbidity and mortality. In collaboration, the Jacobs and Herold laboratories generated an attenuated herpes simplex virus type 2 (HSV-2) strain deleted in glycoprotein D (HSV-2 ΔgD) and demonstrated that it triggers an FcγRIV activating response that elicits both antibody-dependent cell-mediated cytotoxicity and phagocytosis. The antibodies rapidly clear virus and prevent the establishment of latency in mice and guinea pigs following challenge with several clinical isolates of both HSV-1 and HSV-2. We there

APA, Harvard, Vancouver, ISO, and other styles

43

Hofemeister, Helmut, and Peter O'Hare. "Nuclear Pore Composition and Gating in Herpes Simplex Virus-Infected Cells." Journal of Virology 82, no. 17 (2008): 8392–99. http://dx.doi.org/10.1128/jvi.00951-08.

Full text

Abstract:

ABSTRACT The mechanism by which herpes simplex virus (HSV) exits the nucleus remains a matter of controversy. The generally accepted route proposes that capsids exit via primary envelopment at the inner nuclear membrane and subsequent fusion of this primary particle with the outer nuclear membrane to gain capsid entry to the cytoplasm. However, recent observations indicate that HSV may induce gross morphological alterations of nuclear pores, resulting in the loss of normal pores and the appearance of dilated gaps in the nuclear membrane of up to several 100 nm. On this basis, it was proposed t

APA, Harvard, Vancouver, ISO, and other styles

44

Cao, L. T. "Mystery of tumor specific immunity: LIGHT turns on silent tumor specific immunity." Journal of Clinical Oncology 24, no. 18_suppl (2006): 20107. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.20107.

Full text

Abstract:

20107 Background: More than 2000 tumor antigens have been identified so far. However, none of these tumor antigens are approved to be immunogenic. Genetic alteration which activates uncontrolled cell growth transforms normal cells to tumor cells. Tumor cells, therefore, do not carry any foreign antigens and thus tumor antigens are not immunogenic (unless in the presence of viral infection). The so-called tumor specific immunity is actually the host versus graft effect, not specific for tumors. Methods and Results: Using proper controlled tissue graft as control, our previous data indicated tha

APA, Harvard, Vancouver, ISO, and other styles

45

Brunetti, Craig R., Kevin S. Dingwell, Cathy Wale, Frank L. Graham, and David C. Johnson. "Herpes Simplex Virus gD and Virions Accumulate in Endosomes by Mannose 6-Phosphate-Dependent and -Independent Mechanisms." Journal of Virology 72, no. 4 (1998): 3330–39. http://dx.doi.org/10.1128/jvi.72.4.3330-3339.1998.

Full text

Abstract:

ABSTRACT Herpes simplex virus (HSV) glycoprotein D (gD) is modified with mannose 6-phosphate (M6P) and binds to M6P receptors (MPRs). MPRs are involved in the well-characterized pathway by which lysosomal enzymes are directed to lysosomes via a network of endosomal membranes. Based on the impaired ability of HSV to form plaques under conditions in which glycoproteins could not interact with MPRs, we proposed that MPRs may function during HSV egress or cell-to-cell spread (C. R. Brunetti, R. L. Burke, B. Hoflack, T. Ludwig, K. S. Dingwell, and D. C. Johnson, J. Virol. 69:3517–3528, 1995). To fu

APA, Harvard, Vancouver, ISO, and other styles

46

Kenney, Jessica, Aixa Rodríguez, Larisa Kizima, et al. "A Modified Zinc Acetate Gel, a Potential Nonantiretroviral Microbicide, Is Safe and Effective against Simian-Human Immunodeficiency Virus and Herpes Simplex Virus 2 InfectionIn Vivo." Antimicrobial Agents and Chemotherapy 57, no. 8 (2013): 4001–9. http://dx.doi.org/10.1128/aac.00796-13.

Full text

Abstract:

ABSTRACTWe previously showed that a prototype gel comprising zinc acetate (ZA) in carrageenan (CG) protected mice against vaginal and rectal herpes simplex virus 2 (HSV-2) challenge as well as macaques against vaginal simian-human immunodeficiency virus reverse transcriptase (SHIV-RT) challenge. In this work, we modified buffers and cosolvents to obtain a stable, nearly iso-osmolal formulation and evaluated its safety and efficacy against SHIV-RT and HSV-2.In vitrotoxicity to lactobacilli andCandida albicanswas determined. Macaques were given daily doses of ZA and CG (ZA/CG) or CG alone vagina

APA, Harvard, Vancouver, ISO, and other styles

47

Olivo, P. D. "Transgenic cell lines for detection of animal viruses." Clinical Microbiology Reviews 9, no. 3 (1996): 321–34. http://dx.doi.org/10.1128/cmr.9.3.321.

Full text

Abstract:

Rapid diagnostic assays based on direct detection of viral antigen or nucleic acid are being used with increasing frequency in clinical virology laboratories. Virus culture, however, remains the only way to detect infectious virus and to analyze clinically relevant viral phenotypes, such as drug resistance. Growth of viruses in cell culture is labor intensive and time-consuming and requires the use of many different cell lines. Transgenic technology, together with increasing knowledge of the molecular pathways of virus replication, offers the possibility of using genetically modified cell line

APA, Harvard, Vancouver, ISO, and other styles

48

Luganini, Anna, Patrizia Caposio, Santo Landolfo, and Giorgio Gribaudo. "Phosphorothioate-Modified Oligodeoxynucleotides Inhibit Human Cytomegalovirus Replication by Blocking Virus Entry." Antimicrobial Agents and Chemotherapy 52, no. 3 (2008): 1111–20. http://dx.doi.org/10.1128/aac.00987-07.

Full text

Abstract:

ABSTRACT Studies in animal models have provided evidence that Toll-like receptor 9 (TLR9) agonists, such as synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory deoxycytidyl-deoxyguanosine (CpG) motifs (CpG ODNs), protect against a wide range of viral pathogens. This antiviral activity has been suggested to be indirect and secondary to CpG-induced cytokines and inflammatory responses triggered through TLR9 activation. However, few studies have addressed the potential of CpG ODNs as direct antiviral agents. Here, we report on the ability of some CpG ODNs to directly suppress, a

APA, Harvard, Vancouver, ISO, and other styles

49

Dudas, Kathleen C., and William T. Ruyechan. "Identification of a Region of the Herpes Simplex Virus Single-Stranded DNA-Binding Protein Involved in Cooperative Binding." Journal of Virology 72, no. 1 (1998): 257–65. http://dx.doi.org/10.1128/jvi.72.1.257-265.1998.

Full text

Abstract:

ABSTRACT We have identified a region of the herpes simplex virus major DNA-binding protein (ICP8) which is involved in cooperative binding to single-stranded DNA. This has been accomplished by analysis of ICP8 which was covalently modified by reaction with the extrinsic fluorophore fluorescein-5-maleimide (FM). Reaction conditions which result in the incorporation of 1 mol of FM per mol of ICP8 have been established. The binding properties of the modified protein were analyzed by polyacrylamide gel shift analysis with model oligonucleotides. This analysis indicates that while intrinsic binding

APA, Harvard, Vancouver, ISO, and other styles

50

Agius, E., G. Arthur, K. Mandhyan, and D. Mercey. "Polymerase chain reaction for diagnosis of genital herpes: a missed opportunity?" International Journal of STD & AIDS 16, no. 8 (2005): 579–81. http://dx.doi.org/10.1258/0956462054679197.

Full text

Abstract:

This study audited the utilization of herpes simplex virus polymerase chain reaction (HSV PCR) in the investigation of recurrent anogenital ulceration at the Mortimer Market Centre. Clinic guidelines for use of HSV PCR were modified in April 2003 to expand PCR use. Ninety-six case-notes belonging to patients presenting with recurrent anogenital ulceration between 1 April and 16 October 2003 were reviewed and 59 were suitable for inclusion. Details of the investigations carried out at each visit were recorded. HSV PCR was used according to guidelines in eight of the 59 cases studied. This audit

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!