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Journal articles on the topic 'Modified mayo score'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Rocha Silva, J. C., J. Rodrigues, A. Rodrigues, et al. "P270 Ulcerative colitis disease extent and inflammatory burden assessment: DUBLIN and modified Nancy score." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S285—S286. http://dx.doi.org/10.1093/ecco-jcc/jjz203.399.

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Abstract Background Current endoscopic activity scores for ulcerative colitis (UC) do not take into account the extent of mucosal inflammation. The DUBLIN score (Degree of Ulcerative Colitis Burden of Luminal Inflammation) is a simple bedside clinical score that estimates inflammatory burden using both disease severity and extent, which correlates with objective inflammatory markers and is associated with clinical outcomes. The validated Nancy score is used to evaluate histological activity; nonetheless, it does not take in consideration disease extension. We aimed to evaluate the relation of

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2

Sandborn, William J., Bruce E. Sands, Séverine Vermeire, et al. "Modified Mayo score versus Mayo score for evaluation of treatment efficacy in patients with ulcerative colitis: data from the tofacitinib OCTAVE program." Therapeutic Advances in Gastroenterology 15 (January 2022): 175628482211363. http://dx.doi.org/10.1177/17562848221136331.

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Objectives: The subjectivity of the Physician Global Assessment (PGA) is a limitation of the Mayo score in assessing severity of ulcerative colitis (UC). We compared treatment efficacy using endpoint definitions based on modified Mayo (mMayo) score, versus those based on Mayo score, using data from the tofacitinib OCTAVE program. Design: This post hoc analysis included data from two 8-week induction studies (OCTAVE Induction 1 and 2) and a 52-week maintenance study (OCTAVE Sustain). Methods: Remission and clinical response [with nonresponder imputation (NRI)] were assessed using mMayo (without

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3

Danese, S., W. Afif, M. Abreu, et al. "OP15 Efficacy of ustekinumab for Ulcerative Colitis through 4 years: Final clinical and endoscopy outcomes from the UNIFI long-term extension." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i19—i20. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0015.

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Abstract Background Ustekinumab (UST) is an interleukin12/23p40 antagonist approved for treatment of moderate to severe Ulcerative Colitis (UC). Here we report final clinical outcomes based on the Mayo score, including the endoscopy subscore, from the UNIFI long-term extension (LTE) study through 4 years of UST treatment. Methods Overall, 523 intravenous UST induction responders were randomised to subcutaneous maintenance therapy: 175 placebo (PBO); 172 UST 90 mg every 12 weeks (q12w); 176 UST 90 mg q8w. A total of 284 UST patients (pts) completed week (wk)44 and continued treatment in the LTE

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4

Sandborn, W., S. Danese, J. Leszczyszyn, et al. "OP33 Oral ritlecitinib and brepocitinib in patients with Moderate to Severe Active Ulcerative Colitis: Data from the VIBRATO umbrella study." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S030—S031. http://dx.doi.org/10.1093/ecco-jcc/jjab075.032.

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Abstract Background The efficacy and safety of oral ritlecitinib (JAK3/TEC inhibitor) and brepocitinib (TYK2/JAK1 inhibitor) were assessed in a 32-week Phase 2b induction-maintenance umbrella study (VIBRATO) in participants with moderate to severe active ulcerative colitis who had inadequate or loss of response, or intolerance to corticosteroids, immunosuppressants, or biologic therapies. We report efficacy and safety results from the 8-week induction period of the VIBRATO study. Methods Adult participants with Total Mayo Score ≥6 and centrally-read Mayo endoscopic subscore ≥1 were randomised

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Sandborn, William, Bruce Sands, Flavio Steinwurz, et al. "P113 EVALUATION OF THE EFFICACY OF TOFACITINIB IN PATIENTS WITH ULCERATIVE COLITIS UTILIZING THE MODIFIED MAYO SCORE: DATA FROM THE OCTAVE PROGRAM." Inflammatory Bowel Diseases 26, Supplement_1 (2020): S17—S18. http://dx.doi.org/10.1093/ibd/zaa010.041.

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Abstract Introduction Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of ulcerative colitis (UC). Safety and efficacy of tofacitinib were evaluated in 2 Phase 3 induction studies (OCTAVE Induction 1 & 2, NCT01465763 & NCT01458951), a 52-week (wk), Phase 3 maintenance study (OCTAVE Sustain, NCT01458574),1 and an ongoing open-label, long-term extension study (NCT01470612).2 In these trials, endpoint definitions were based on the conventional Mayo score comprising 4 subscores (stool frequency, rectal bleeding, endoscopic findings, Physician Global Assessment [PGA]).

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Swenson, Anna, Kristin Burke, Katherine Womack, Meaghan Quinn, and Gary Curhan. "METHODS TO DERIVE A MODIFIED MAYO SCORE FROM ELECTRONIC HEALTH RECORDS DATA." Inflammatory Bowel Diseases 29, Supplement_1 (2023): S21. http://dx.doi.org/10.1093/ibd/izac247.040.

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Abstract BACKGROUND The modified Mayo Score (MMS), which consists of stool frequency, rectal bleeding, and endoscopic subscores, is the most commonly used method for measuring disease activity in Ulcerative Colitis (UC) patients. It is a standard outcome measure in clinical trials, and is recommended as a clinical trial endpoint by the US Food and Drug Administration. Each component has a score from 0-3; the total MMS ranges from 0 to 9. MMS is infrequently recorded in routine care, in part because it requires an endoscopic assessment. Real world data, including electronic health record (EHR)

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7

Rasheed, Zahid, Sauleha Sayyed, Imran Ali, et al. "Diagnostic Accuracy of Modified Alvarado Score (MAS) and Ohmann Scores (OS) in Diagnosing Acute Appendicitis." Pakistan Journal of Medical and Health Sciences 17, no. 3 (2023): 298–300. http://dx.doi.org/10.53350/pjmhs2023173298.

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In the field of General Surgery AA is the frequent clinical condition for which patients who need emergency surgery present with abdominal pain.1 Diagnosis of this pathology is made with the help of history, patient symptoms, and clinical exam and lab investigations. Ultrasonography (USG) and computed tomography (CT) images for acute appendicitis should be considered.2 Methodology: The purpose of the study is to compare the diagnostic accuracy of Modified Alvarado Score (MAS) and Ohmann Scores (OS) in diagnosing the pathology of Acute Appendicitis, while retaining histopathology as the basis f

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8

Swenson, Anna, Kristin Burke, Katherine Womack, Meaghan Quinn, and Gary Curhan. "METHODS TO DERIVE A MODIFIED MAYO SCORE FROM ELECTRONIC HEALTH RECORDS DATA." Gastroenterology 164, no. 4 (2023): S27. http://dx.doi.org/10.1053/j.gastro.2023.03.057.

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9

Luchetti, R., I. Papini Zorli, A. Atzei, and T. Fairplay. "Dorsal intercarpal ligament capsulodesis for predynamic and dynamic scapholunate instability." Journal of Hand Surgery (European Volume) 35, no. 1 (2009): 32–37. http://dx.doi.org/10.1177/1753193409347686.

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We treated a prospective series of 18 patients (nine men and nine women) with a mean age of 35 years (range 15 to 57), with chronic predynamic or dynamic scapholunate instability by a dorsal intercarpal ligament capsulodesis using the modified Mayo technique. All the patients were assessed by the modified Mayo wrist score and DASH questionnaire. Wrist arthroscopy was done in all patients before open surgery in order to grade the scapholunate instability and correlate the findings with the radiographic and MRI results. At an average follow-up of 45 months (range 34 to 60) pain significantly dim

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10

Yoshida, Shiro, Kenji Yoshida, Kensuke Sakai, Kenjiro Nakama, and Naoto Shiba. "Frequency of Scapholunate Ligament Injuries Associated with Distal Radius Shearing Fracture: Correlation of Fracture Patterns and Ligament Tear." Hand Surgery 20, no. 03 (2015): 440–46. http://dx.doi.org/10.1142/s0218810415500379.

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Background: This retrospective study assessed the prevalence and outcome of intercarpal ligament injuries in non-osteoporotic patients with AO/ASIF classification type B distal radius shearing fractures treated with or without scapholunate temporary fixation. Methods: Fifteen patients (mean age, 33 years) were analyzed according to their scapholunate ligament status at the time of injury and graded with a modified Geissler classification system. Each patient’s postoperative pain and occupational status were assessed in the context of the Modified Mayo wrist score. Second-look arthroscopy was p

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Nordaas, Ingrid Kvåle, Trond Engjom, Odd Helge Gilja, et al. "Diagnostic Accuracy of Transabdominal Ultrasound and Computed Tomography in Chronic Pancreatitis: A Head-to-Head Comparison." Ultrasound International Open 07, no. 01 (2021): E35—E44. http://dx.doi.org/10.1055/a-1542-9146.

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Abstract Purpose Computed tomography (CT) is the most used imaging modality for diagnosing chronic pancreatitis (CP), but advances in transabdominal ultrasound (US) technology have given US a position as a viable alternative. We aimed to evaluate the diagnostic accuracy of abdominal CT and pancreatic US compared to the reference standard, a modified Mayo score. Materials and Methods CT, US, and endoscopic ultrasound (EUS) were performed in patients referred due to suspected CP. The modified Mayo score included EUS results, clinical presentation, and results from exocrine and endocrine pancreat

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Özdemir, Güzelali, Turgut Akgül, Özgür Çiçekli, Barış Yılmaz, Hasan Atbinici, and Ferit Yücel. "Lunatum excision and scaphocapitate arthrodesis in Kienböck’s disease." Journal of Orthopaedic Surgery 25, no. 1 (2017): 230949901769270. http://dx.doi.org/10.1177/2309499017692704.

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Purpose: The aim of this study was to compare functional results before and after lunatum excision and scaphocapitate arthrodesis (SCA) using an angular stable circular plate in patients with Lichtman’s stage IIIB Kienböck’s disease. Methods: The study included nine patients (six females and three males) with a mean age of 33.2 ± 11 years (range: 18–54 years). Clinical and radiological assessment before and after surgery included wrist extension and flexion, range of motion and grip strength, visual analogue scale (VAS) score to assess pain, modified Mayo wrist scores, and measurements of the

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Estrella, Emmanuel P., and Paulo L. Panti. "OUTCOME OF UNSTABLE DISTAL RADIUS FRACTURES TREATED WITH OPEN REDUCTION AND INTERNAL FIXATION VERSUS EXTERNAL FIXATION." Hand Surgery 17, no. 02 (2012): 173–79. http://dx.doi.org/10.1142/s0218810412500165.

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The objective of this study was to compare the clinical results of unstable distal radius fractures treated with ORIF with plate and screws compared to EF. Patients with unstable distal radius fractures treated with ORIF or EF from January 2005 to December 2010 were reviewed in terms of the Modified Mayo Wrist Score, range of motion, pain, grip strength, and radiologic parameters. Results showed that there was no difference in the Modified Mayo Wrist Score between ORIF (17 patients) and EF (11 patients) (p = 0.07). The ORIF group had better wrist flexion, wrist extension, pronation and supinat

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Mahmoud, Mostafa, and Ahmed Afifi. "Should all superficial peripheral triangular fibrocartilage complex tears be arthroscopically repaired?" Egyptian Orthopaedic Journal 56, no. 1 (2021): 35–41. http://dx.doi.org/10.4103/eoj.eoj_80_21.

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Background Superficial peripheral triangular fibrocartilage complex (TFCC) tears are commonly encountered during diagnostic wrist arthroscopy done for other causes of wrist pain. The authors hypothesized that debridement of these tears in symptomatic post-traumatic superficial tears may be a sufficient alternative to arthroscopic repair. Patients and methods The authors conducted a prospective study including 29 patients with superficial peripheral TFCC tears (with no distal radioulnar joint instability) treated arthroscopically between 2011 and 2014. There were 26 males (89.7%) and three fema

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Zaidenberg, Ezequiel E., Mariano O. Abrego, Agustin G. Donndorff, Jorge G. Boretto, Pablo De Carli, and Gerardo L. Gallucci. "Treatment of terrible triad injuries at a mean follow-up of nine years." Shoulder & Elbow 11, no. 6 (2018): 450–58. http://dx.doi.org/10.1177/1758573218809375.

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Background To evaluate the sustainability of the early clinical and radiological outcomes of terrible triad injuries at long-term follow-up. Methods Twelve consecutive patients who underwent fixation of terrible triad injuries with minimum of seven years of follow-up. Functional and radiological outcomes at one year and final follow-up were compared. We assessed Mayo Elbow Performance Score, Quick-Disability of the Arm Shoulder and Hand, and modified-American Shoulder and Elbow Surgeons Scores. Radiological evaluation included Broberg and Morrey classification and Hastings classification for h

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Kunishige, Ren, Kiyohito Naito, Hiroyuki Obata, So Kawakita, Takamaru Suzuki, and Muneaki Ishijima. "Comparison of Conventional Incision and 10 mm Approach for Volar Locking Plates in Dorsal Displaced Distal Radius Fractures." Journal of Orthopaedic Case Reports 14, no. 6 (2024): 186–90. http://dx.doi.org/10.13107/jocr.2024.v14.i06.4546.

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Introduction: The aim of this study was to investigate whether surgery with a 10 mm approach for volar locking plate fixation provides equivalent early post-operative outcomes to conventional incision surgery for distal radius fractures. Materials and Methods: The subjects were divided into a conventional incision group (mean age: 59.1 years, 8 males and 23 females) and a 10 mm approach group (mean age: 59.9 years of age, 6 males and 20 females). The wrist range of motion; grip strength; visual analog scale (VAS); quick disabilities of the arm, shoulder, and hand (Q-DASH) score; and modified M

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Gottlieb, E., D. Binion, B. Feagan, et al. "P726 A phase 2 study investigating the efficacy and safety of dupilumab versus placebo in adults with moderately to severely active ulcerative colitis with an eosinophilic phenotype." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i1364—i1365. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0856.

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Abstract Background Ulcerative colitis (UC) is a heterogeneous, chronic inflammatory disease, with many different drivers of pathogenesis, characterised by inflammation of the colon mucosa, relapsing–remitting disease course and variable response to therapy. Around 30–55% of patients with UC are refractory to treatment during the induction phase, despite the availability of molecular targeted agents. Recent studies have investigated a potential link between eosinophilia and increased disease activity, poorer clinical outcomes and response to therapy. Dupilumab is a fully human monoclonal antib

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Sandeep, V. S., Surendran Sibin, Jojoinassi, and Kumar N. S. Akshay. "Clinical and Radiological Outcome of Extra articular and in tra articular distal radius fractures in adults treated using "5K wire technique"- A descriptive Study." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 1797–803. https://doi.org/10.5281/zenodo.12747561.

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<strong>Background:</strong> Distal radius fractures are common injuries, and various treatment methods have been described. This study aimed to assess the clinical and radiological outcomes of extra-articular and intra-articular distal radius fractures treated using the 5 K-wire technique. <strong>Methods:</strong> A prospective descriptive study was conducted on 44 patients with distal radius fractures treated using the 5 K-wire technique. Functional outcomes were assessed using the Modified Mayo Score and Patient-Rated Wrist Evaluation (PRWE) score at 6 weeks, 3 months, and 6

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Kawakatsu, Sonoko, Rui Zhu, Wenhui Zhang, et al. "A longitudinal model for the Mayo Clinical Score and its sub-components in patients with ulcerative colitis." Journal of Pharmacokinetics and Pharmacodynamics 49, no. 2 (2021): 179–90. http://dx.doi.org/10.1007/s10928-021-09789-2.

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AbstractClinical trials in patients with ulcerative colitis (UC) face the challenge of high and variable placebo response rates. The Mayo Clinical Score (MCS) is used widely as the primary endpoint in clinical trials to describe the clinical status of patients with UC. The MCS is comprised of four subscores, each scored 0, 1, 2 and 3: rectal bleeding (RB), stool frequency (SF), physician’s global assessment (PGA), and endoscopy (ENDO) subscore. Excluding the PGA subscore gives the modified MCS. Quantitative insight on the placebo response, and its impact on the components of the MCS over time,

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Dimitrios, G., K. Athanasios, K. Ageliki, and S. Spiridon. "Capitolunate arthrodesis maintaining carpal height for the treatment of SNAC wrist." Journal of Hand Surgery (European Volume) 35, no. 3 (2009): 198–201. http://dx.doi.org/10.1177/1753193409352280.

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The clinical and radiological results of a modified midcarpal fusion technique for scaphoid nonunion advance collapse were retrospectively studied in eight patients. All had partial resection of the proximal part of the fractured scaphoid, limited radial styloidectomy, scaphocapitate and lunocapitate arthrodesis, using a block of iliac crest graft to maintain carpal height. All united without complications and wrist motion, grip strength and carpal height were improved postoperatively. The modified Mayo wrist score at follow-up was 70%. Three patients continued to have some pain and one patien

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Sun, Y., and H. Yang. "P0811 Comparative efficacy of vedolizumab and infliximab in patients with moderate-to-severe ulcerative colitis: a multicenter real world cohort study." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i1554. https://doi.org/10.1093/ecco-jcc/jjae190.0985.

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Abstract Background Vedolizumab (VDZ) and infliximab (IFX) are both recognized as first-line treatment options for moderate to severe ulcerative colitis (UC). However, there is a paucity of comparative studies examining their real-world efficacy. Methods Patients with moderate to severe UC were consecutively enrolled from 11 centers. Efficacy were evaluated after 14 and 52 weeks. Logistic regression was conducted to identify independent risk factors for clinical remission. Results A total of 235 patients were enrolled, of which 154 received VDZ treatment and 81 received IFX treatment. 154 (65.

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Liu, Lupeng, Hui Ouyang, Jingling Su, et al. "Increased modified DUBLIN scores are associated with serious ulcerative colitis and treatment failure." Therapeutic Advances in Gastroenterology 15 (January 2022): 175628482211426. http://dx.doi.org/10.1177/17562848221142671.

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Background: Grading of endoscopic lesions is important for determining the severity of ulcerative colitis and developing treatment strategies, but the commonly used methods are not sufficient. Objectives: This study aimed to investigate whether new endoscopic scoring systems incorporating lesions and disease extent are associated with clinical disease severity and maintainable remission. Design: This was a retrospective study. In all, 110 patients with ulcerative colitis were included and 87 completed 12-month follow-up. Methods: Colonoscopy was performed within 1 week before blood samples wer

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Xie, C., J. Su, L. Liu, Y. Lin, Y. Hu, and H. Shi. "P321 Increased modified DUBLIN scores are associated with serious ulcerative colitis and treatment failure." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i461—i462. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0451.

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Abstract Background Grading of endoscopic lesions is important for determining the severity of ulcerative colitis and developing treatment strategies, but the commonly used methods are not sufficient.This study aimed to investigate whether new endoscopic scoring systems incorporating lesions and disease extent are associated with clinical disease severity and maintainable remission. Methods This was a retrospective study. One hundred and ten patients with ulcerative colitis were included and eighty seven completed 12 months follow-up.Colonoscopy was performed within 1week before blood samples

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Abosalem, Ahmed, Ahmed Shams, and Mohamed Samy. "Evaluation of treatment of nonunited middle third scaphoid fractures using threaded Kirschner wires fixation with iliac bone grafting." Egyptian Orthopaedic Journal 58, no. 2 (2023): 100–105. http://dx.doi.org/10.4103/eoj.eoj_60_22.

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Abstract Objectives To evaluate the results of iliac bone grafting with threaded Kirschner wires (K-wires) fixation in treating of nonunited middle third scaphoid fractures. Background Scaphoid nonunion is a common complication after scaphoid fractures as it is an intra-articular fracture with high fracture mobility and instability. In addition, the scaphoid is devoid of periosteum along with impaired vascularity. Scaphoid nonunion results in carpal collapse with secondary osteoarthritis. To avoid that, the aim of treatment should be to enhance the biology of fracture through bone grafting and

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Soreide, Endre, Jan-Ragnar Haugstvedt, and Torstein Husby. "Arthroscopic Assisted Resection of Triangular Fibrocartilage Complex Lesions: A 19-Year Follow-up." HAND 13, no. 3 (2017): 325–30. http://dx.doi.org/10.1177/1558944717708029.

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Background: This study assesses long-term functional and subjective outcomes following arthroscopic assisted resection of lesions of the triangular fibrocartilage complex (TFCC). Methods: Functional and subjective outcomes were assessed based on review of patient charts for patient demographic characteristics, comprehensive clinical evaluation, obtained radiographs, and patient-reported questionnaires. Results: Fifteen patients, of whom 9 were female, and 10 dominant wrists, were included in this study. Median age was 60 (range, 37-73) years, and median duration of follow-up was 19 (range, 18-

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ADOLFSSON, L., and P. JÖRGSHOLM. "Arthroscopically-Assisted Reduction of Intra-Articular Fractures of the Distal Radius." Journal of Hand Surgery 23, no. 3 (1998): 391–95. http://dx.doi.org/10.1016/s0266-7681(98)80065-x.

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Twenty-seven patients with intraarticular fractures of the distal radius with a step of more than 1 mm in the joint surface after attempted closed reduction, were treated by reduction under arthroscopic control and percutaneous fixation. All fractures healed without measurable incongruity of the joint surface and at follow-up 3 to 38 months after surgery 19 patients had excellent and eight patients good results according to the Mayo modified wrist score.

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Dhingra, Parakh, D. S. Meena, Ravi Khurana, Kartik Samria, and Devanshi Vijay. "Functional and radiological outcomes of Madelung and Madelung-like deformities corrected with corrective osteotomies of radius with or without ulnar shortening." International Journal of Research in Orthopaedics 11, no. 3 (2025): 575–81. https://doi.org/10.18203/issn.2455-4510.intjresorthop20251137.

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Background: Madelung deformity results from a bony and ligamentous dysplasia at the wrist, leading to palmar displacement of the hand on a shortened, bowed forearm. It is commonly associated with dorsal subluxation and prominence of the ulnar head, which collectively contribute to restricted wrist range of motion. Methods: This study included 15 patients diagnosed with Madelung and Madelung-like deformity, with a mean age of 15 years (range: 10–21 years). All patients underwent clinical and radiographic evaluations. Various surgical techniques were employed, including dorsolateral closed-wedge

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Lee, Young-Keun. "Treatment of subacute/chronic ECU tendinopathy using wrist arthroscopy and open surgical repair." Journal of Orthopaedic Surgery 30, no. 1 (2022): 230949902110670. http://dx.doi.org/10.1177/23094990211067009.

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Purpose To report the arthroscopic and clinical findings of patients with extensor carpi ulnaris (ECU) tendinopathy treated with wrist arthroscopy and open surgical repair. Methods We retrospectively reviewed the medical records of seven patients with chronic ECU tendinopathy who were treated with diagnostic wrist arthroscopy and open surgical repair between 2010 and 2017. Seven cases diagnosed with ECU tendinopathy had undergone open procedure for the ECU tendinopathy, as well as wrist arthroscopy in the same session. Any pathology of the triangular fibrocartilage complex (TFCC) diagnosed by

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Sandborn, W. J., M. C. Dubinsky, J. Torres, et al. "DOP61 Impact of prior tumour necrosis factor inhibitor failure and prior corticosteroid use on the maintenance of efficacy of tofacitinib following dose reduction in patients with Ulcerative Colitis who were in stable remission: 6-month data from the double-blind, randomised RIVETING study." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S096—S097. http://dx.doi.org/10.1093/ecco-jcc/jjab073.100.

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Abstract Background Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of ulcerative colitis (UC). RIVETING (NCT03281304) is an ongoing, double-blind, randomised, parallel-group study designed to evaluate the efficacy and safety of dose reduction to tofacitinib 5 mg twice daily (BID) vs remaining on 10 mg BID in patients (pts) with UC in stable remission on tofacitinib 10 mg BID maintenance therapy. Eligible pts had received tofacitinib 10 mg BID for ≥2 consecutive years in an open-label, long-term extension (OLE) study (NCT01470612), and had been in stable remission for ≥6

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Dubinsky, M. C., G. R. D’Haens, W. J. Sandborn, et al. "P336 Association between the prior duration of remission and efficacy outcomes in patients with Ulcerative Colitis treated with tofacitinib 10 mg twice daily who were in stable remission and either dose-reduced to tofacitinib 5 mg twice daily or remained on 10 mg twice daily: 6-month data from the double-blind, randomised RIVETING study." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S361—S362. http://dx.doi.org/10.1093/ecco-jcc/jjab076.460.

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Abstract Background Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of ulcerative colitis (UC). RIVETING (NCT03281304) is an ongoing, double-blind, randomised, parallel-group study designed to evaluate the efficacy and safety of dose reduction to tofacitinib 5 mg twice daily (BID) vs remaining on 10 mg BID in patients (pts) with UC in stable remission on tofacitinib 10 mg BID maintenance therapy. Eligible pts had received tofacitinib 10 mg BID for ≥2 consecutive years in an open-label, long-term extension study (NCT01470612), and had been in stable remission for ≥6 month

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Iacucci, Marietta, Rosanna Cannatelli, Xianyong Gui, et al. "Assessment of Endoscopic Healing by Using Advanced Technologies Reflects Histological Healing in Ulcerative Colitis." Journal of Crohn's and Colitis 14, no. 9 (2020): 1282–89. http://dx.doi.org/10.1093/ecco-jcc/jjaa056.

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Abstract Background Several studies have reported that ulcerative colitis [UC] patients with endoscopic mucosal healing may still have histological inflammation. We investigated the relationship between mucosal healing defined by modified PICaSSO [Paddington International Virtual ChromoendoScopy ScOre], Mayo Endoscopic Score [MES] and probe-based confocal laser endomicroscopy [pCLE] with histological indices in UC. Methods A prospective study enrolling 82 UC patients [male 66%] was conducted. High-definition colonoscopy was performed to evaluate the activity of the disease with MES assessed wi

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Solitano, V., R. Panaccione, B. E. Sands, et al. "P280 Comparative responsiveness of disease activity indices in moderately-to-severely active Ulcerative Colitis: a post-hoc analysis of the UNIFI trial." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i647—i648. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0410.

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Abstract Background Clinical, endoscopic, histological, and composite instruments are used to measure disease activity in ulcerative colitis (UC). We compared responsiveness of the Mayo Clinic Score (MCS), modified Mayo Clinic Score (mMS), partial Mayo Clinic Score (pMS), Robarts Histopathology Index (RHI), and UC-100 score after treatment with ustekinumab in patients with moderately-to-severely active UC. Methods Publicly available data from the phase 3 UNIFI induction trial (NCT02407236) comparing the efficacy and safety of ustekinumab versus placebo in patients with moderate-to-severe UC we

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Bhan, Kavyansh, and Randhir Kenjle. "Efficacy, safety and tolerability of autologous platelet rich plasma injection in the treatment of lateral epicondylitis." International Journal of Research in Orthopaedics 5, no. 6 (2019): 1121. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20194817.

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<p class="abstract"><strong>Background:</strong> To evaluate the effects of platelet-rich plasma (PRP) infiltration in patients with lateral epicondylitis of the elbow.</p><p class="abstract"><strong>Methods:</strong> A randomized, prospective study on 60 patients with lateral epicondylitis of the elbow was conducted at Ruby Hall Clinic, Pune. The patients were randomized and evaluated after receiving infiltration of three milliliters of PRP, or methyl prednisolone. The base-line evaluation was done using visual analog score (VAS) and modified Mayo per

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Levesque, Barrett, Suresh Pola, Debra King, et al. "Tu1119 Responsiveness of Central Endoscopic Assessment of Disease Activity Using the Modified Mayo Clinic Score in Ulcerative Colitis." Gastroenterology 144, no. 5 (2013): S—767. http://dx.doi.org/10.1016/s0016-5085(13)62835-8.

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Naegeli, April, Xiang Zhang, Theresa Hunter, et al. "Full, Partial, or Modified: Understanding Relationships Between Permutations of the Mayo Score in Real-World Ulcerative Colitis Patients." American Journal of Gastroenterology 113, Supplement (2018): S384. http://dx.doi.org/10.14309/00000434-201810001-00684.

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Lone, Sukhil Raina, Tanveer Ahmed Bhat, Zubair Ahmad Lone, et al. "Outcome of volar Barton fractures of distal radius managed with open reduction and internal fixation with volar locking plate." International Journal of Research in Medical Sciences 11, no. 2 (2023): 584–87. http://dx.doi.org/10.18203/2320-6012.ijrms20230168.

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Background: Volar Barton fractures of distal radius almost always require a surgical fixation. Near anatomical reduction and a stout fixation is imperative for good outcome. The present study aimed at studying the outcome of open reduction and internal fixation with volar locking plate for volar Barton fractures. Methods: The present study included 25 patients with volar Barton fractures of distal radius presenting to the orthopaedic department who were managed with volar locking plate. The minimum follow-up period was 12 months. Wrist movements were recorded and outcome was studied using modi

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Verma, Ashish, Laxmi Narayan Meena, and B. L. Kumar. "Evaluation of functional outcome by modified mayo wrist score in intra- articular distal end radius fracture managed by plate osteosynthesis." International Journal of Research in Orthopaedics 9, no. 1 (2022): 102. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20223446.

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<p class="abstract"><strong>Background:</strong> Fractures of distal end of radius continue to pose a therapeutic challenge. Intra articular and extra articular malalignment can lead to various complications like post traumatic osteoarthrosis, decreased grip strength and endurance, as well as limited motion and carpal instability.</p><p class="abstract"><strong>Methods:</strong> A prospective study of forty patients with intra-articular distal end radial fractures treated under the department of orthopaedics, PIMS, Udaipur, were included in this study.

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Cremer, A., T. Lobaton, S. Vieujan, et al. "P422 Tofacitinib induces clinical and endoscopic remission in biologic refractory ulcerative colitis patients: a real-world Belgian cohort study." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S384—S386. http://dx.doi.org/10.1093/ecco-jcc/jjz203.551.

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Abstract Background Tofacitinib, an oral small molecule Janus kinase inhibitor, has been approved in 2018 for the treatment of moderate to severe ulcerative colitis (UC) in Europe. We report on real-world short-term efficacy and safety data from a multicenter Belgium refractory cohort of UC patients with prior exposure to both anti-TNFα and vedolizumab. Methods This is an observational, national, retrospective multicentre study including all UC active patients started on tofacitinib (10 mg BID) from 25 centres in Belgium between November 2018 and August 2019. Prospectively collected data were

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Sushil., H. Mankar, A. Jawre Aadil., D. Tumdam Mahesh., and M. Dhanwani Yash. "Results of Open Reduction Internal Fixation versus Conservative Treatment in Cases of Fracture of the Styloid Process of Ulna." International Journal of Pharmaceutical and Clinical Research 15, no. 6 (2023): 1995–2002. https://doi.org/10.5281/zenodo.12529923.

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<strong>Background: </strong>Distal radius fractures constitute about 1/6th of all the fractures that are present. There is an association which is found between fracture of the radius (distal end) and ulna (styloid process). The Ulnar styloid provides support to a very important structure called the Triangular Fibrocartilage complex [TFCC]. According to some surgeons, the fixation of the styloid of the ulna avoids complications (Nonunion, instability). According to other surgeons, there were problems associated with the ulnar styloid fixation like implant prominence and post-surgery scar

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Danese, S., R. Panaccione, G. D’Haens, et al. "DOP42 Efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with moderately-to-severely active Ulcerative Colitis: 12-week results from the Phase 2 LATTICE-UC study." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i091—i092. http://dx.doi.org/10.1093/ecco-jcc/jjab232.081.

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Abstract Background Tyrosine kinase 2 (TYK2) is an intracellular kinase that mediates the signalling of key cytokines involved in ulcerative colitis (UC) pathophysiology. Deucravacitinib (DEUC) is a novel, oral, selective TYK2 inhibitor that binds to the TYK2 regulatory domain. The safety and efficacy of DEUC were evaluated in patients (pts) with moderately-to-severely active UC. Methods LATTICE-UC (NCT03934216), a randomised, double-blind, placebo (PBO)-controlled, multicentre, Phase 2 trial, enrolled pts with moderately-to-severely active UC (modified Mayo score of 5 to 9 [endoscopic {ES} su

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Xu, Tonglong, Xiaoyun Pan, and Jingyi Mi. "Improved Outside-In Suture through the Joint Capsule to Repair the Palmer I-B Triangular Fibrocartilage Complex Superficial Injury." Computational and Mathematical Methods in Medicine 2021 (November 10, 2021): 1–5. http://dx.doi.org/10.1155/2021/8387813.

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Background. The treatment of type I-B triangular fibrocartilage complex superficial injury is always a challenge to orthopedists. The traditional outside-in suture method often causes a risk of nervous irritation. We designed a modified outside-in suture through the joint capsule to repair the Palmer I-B triangular fibrocartilage complex superficial injury. Methods. From December 2014 to December 2018, we retrospectively collected the medical records of 18 patients in our hospital who used the modified outside-in suture through the joint capsule to repair type I-B triangular fibrocartilage com

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D’Haens, G. R., M. C. Dubinsky, M. Regueiro, et al. "P409 Non-invasive predictors of maintaining remission in patients with moderately to severely active Ulcerative Colitis treated with tofacitinib who dose-reduced from tofacitinib 10 mg twice daily to 5 mg twice daily: 6-month data from the double-blind, randomised RIVETING study." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S416—S417. http://dx.doi.org/10.1093/ecco-jcc/jjab076.533.

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Abstract Background Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of ulcerative colitis (UC). RIVETING (NCT03281304) is an ongoing, double-blind, randomised, parallel-group study designed to evaluate the efficacy and safety of dose reduction to tofacitinib 5 mg twice daily (BID) vs remaining on 10 mg BID in patients (pts) with UC in stable remission on tofacitinib 10 mg BID maintenance therapy. Eligible pts had received tofacitinib 10 mg BID for ≥2 consecutive years in an open-label, long-term extension study (NCT01470612), and had been in stable remission for ≥6 month

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Liang, Benjamin, Jen Ming Lai, Arul Murugan, Kin Ghee Chee, Sreedharan Sechachalam, and Tun-Lin Foo. "Proposed Guidelines for Treatment of Concomitant Distal Radius and Distal Ulna Fractures." Hand Surgery 20, no. 03 (2015): 396–401. http://dx.doi.org/10.1142/s0218810415500306.

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Background: Concomitant distal radius and distal ulna metaphysis or head fractures (DRUF) are uncommon and acceptable results have been reported from cast immobilisation and internal fixation. Methods: We reviewed the charts of 1094 patients treated for distal radius fracture at our institution in a two year period from 2009 to 2010. 24 patients with concomitant DRUF with were treated by cast immobilisation (group 1, n = 11), internal fixation of both bones (group 2, n = 7), internal fixation of radius alone (group 3, n = 2), and internal fixation of radius with distal ulna resection (group 4,

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Mavroudis, Georgios, Magnus Simren, Börje Jonefjäll, Lena Öhman, and Hans Strid. "Symptoms compatible with functional bowel disorders are common in patients with quiescent ulcerative colitis and influence the quality of life but not the course of the disease." Therapeutic Advances in Gastroenterology 12 (January 2019): 175628481982768. http://dx.doi.org/10.1177/1756284819827689.

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Background: Whether patients with inactive ulcerative colitis (UC) have symptoms compatible with functional bowel disorders (FBDs) other than irritable bowel syndrome (IBS) is unclear. Our aim was to investigate the prevalence and burden of these symptoms and determine impact on the UC course. Methods: We used Mayo score, sigmoidoscopy and calprotectin (f-cal) to define remission in 293 UC patients. Presence of symptoms compatible with FBD, severity of gastrointestinal, extraintestinal and psychological symptoms, stress levels and quality of life (QoL) were measured with validated questionnair

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Yang, Chen-Yuan, and Wei-Jen Chen. "Arthroscopic transosseous foveal footprint repair of the triangular fibrocartilage complex." Journal of Hand Surgery (European Volume) 47, no. 5 (2022): 486–94. http://dx.doi.org/10.1177/17531934211065874.

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Foveal disruption of the triangular fibrocartilage complex contributes to the instability of distal radioulnar joint. We have developed an arthroscopic transosseous foveal footprint repair technique, which maximizes the contact between the disrupted triangular fibrocartilage complex and its foveal footprint for better healing by using four sutures in a divergent configuration through a 1.6-mm bone tunnel. Twelve patients with triangular fibrocartilage complex foveal injuries who had undergone this repair technique were reviewed with a mean follow-up of 53 months. All patients achieved signific

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Lenfant, M., B. Verstockt, J. Sabino, S. Vermeire, and M. Ferrante. "DOP17 Evaluating segmental healing with the modified Mayo endoscopic score (MMES) has a clear additional value in predicting long-term outcome in patients with Ulcerative Colitis: Results from a prospective cohort study." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i066—i067. http://dx.doi.org/10.1093/ecco-jcc/jjab232.056.

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Abstract Background Most endoscopic scoring systems (including the Mayo endoscopic subscore, MES) do not consider the extent of inflammation and can therefore not pick up segmental endoscopic improvement. The modified Mayo endoscopic score (MMES) was developed to overcome this limitation. We examined the predictive value of the MMES in addition to the MES on long-term clinical outcome in ulcerative colitis (UC). Methods Between 2014 and 2017, patients initiating biologic therapy for active UC (baseline MES ≥2) were recruited. Patients without assessment of the upper margin of inflammation or w

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Ortega, Triana Lobatón, Talat Bessissow, Gert De Hertogh, et al. "Su1280 The Modified Mayo Endoscopic Score (MMES): A New Score for the Assessment of Extension and Severity of Endoscopic Activity in Ulcerative Colitis (UC) Patients." Gastroenterology 146, no. 5 (2014): S—424. http://dx.doi.org/10.1016/s0016-5085(14)61526-2.

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Ortega, T. Lobaton, T. Bessissow, G. De Hertogh, et al. "P124 The Modified Mayo Endoscopic Score (MMES): a new score for the assessment of extent and severity of endoscopic activity in ulcerative colitis (UC) patients." Journal of Crohn's and Colitis 8 (February 2014): S113—S114. http://dx.doi.org/10.1016/s1873-9946(14)60246-4.

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Guo, Zhitao, Yuli Wang, and Yacong Zhang. "Modified Sauve-Kapandji procedure for patients with old fractures of the distal radius." Open Medicine 12, no. 1 (2017): 417–23. http://dx.doi.org/10.1515/med-2017-0060.

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AbstractObjectiveTo evaluate the clinical and radiographic outcomes of a modified Sauve-Kapandji procedure for patients with old fractures in the distal radius.MethodsFifteen patients (10 male and 5 female patients with an average age of 40 years old) were treated by the modified Sauve-Kapandji procedure from January 2014 to April 2016. All patients had undergone at least one previous operation on the involved wrist, and they were still suffering from pain and functional limitations at the time of admission. The postoperative follow-up period was 12-26 months and the average was 20 months. Fun

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Langenhan, R., B. Hohendorff, and A. Probst. "Trapeziectomy and ligament reconstruction tendon interposition for isolated scaphotrapeziotrapezoid osteoarthritis of the wrist." Journal of Hand Surgery (European Volume) 39, no. 8 (2013): 833–37. http://dx.doi.org/10.1177/1753193413514500.

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Isolated osteoarthritis of the scaphotrapeziotrapezoid joint is rather rare compared with thumb trapeziometacarpal osteoarthritis. The aim of this retrospective study was to evaluate the outcome of 15 consecutive patients treated with trapeziectomy/ligament reconstruction tendon interposition for isolated scaphotrapeziotrapezoid osteoarthritis of the wrist. After a mean follow-up of 54 months, 14 patients (15 wrists) were available for clinical and radiological examination. The median pain intensity was 0 on a 0–10 visual analogue scale, both at rest and with activity, mean grip strength avera

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