Relevant bibliographies by topics / Modified Morpholino Nucleosides

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Modified Morpholino Nucleosides'

Author: Grafiati
Published: 7 September 2023
Last updated: 19 July 2025

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Journal articles on the topic "Modified Morpholino Nucleosides"

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Zhang, Nan, Chunyan Tan, Puqin Cai, Peizhuo Zhang, Yufen Zhao, and Yuyang Jiang. "RNA interference in mammalian cells by siRNAs modified with morpholino nucleoside analogues." Bioorganic & Medicinal Chemistry 17, no. 6 (2009): 2441–46. http://dx.doi.org/10.1016/j.bmc.2009.02.001.

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Nandi, Bappaditya, Sankha Pattanayak, Sibasish Paul, and Surajit Sinha. "Synthesis of Nucleobase-Functionalized Morpholino-Modified Nucleoside Monomers Through Palladium-Catalyzed Cross-Coupling Reactions." European Journal of Organic Chemistry 2013, no. 7 (2013): 1271–86. http://dx.doi.org/10.1002/ejoc.201201384.

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Nandi, Bappaditya, Sankha Pattanayak, Sibasish Paul, and Surajit Sinha. "ChemInform Abstract: Synthesis of Nucleobase-Functionalized Morpholino-Modified Nucleoside Monomers Through Palladium-Catalyzed Cross-Coupling Reactions." ChemInform 44, no. 35 (2013): no. http://dx.doi.org/10.1002/chin.201335159.

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4

Papis, Marta, Camilla Loro, Michele Penso, Gianluigi Broggini, and Francesca Foschi. "Synthesis of Morpholino Nucleosides Starting From Enantiopure Glycidol." Organic Chemistry Frontiers, 2022. http://dx.doi.org/10.1039/d2qo00400c.

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A protocol for the synthesis of modified morpholino monomers was performed in few steps through the condensation between 6-hydroxymethyl-morpholine acetal and nucleobases under Lewis acid conditions. The key common precursor...
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5

Bege, Miklós, Vigyasa Singh, Neha Sharma, et al. "In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-39541-4.

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AbstractDrug-resistant Plasmodium falciparum (Pf) infections are a major burden on the population and the healthcare system. The establishment of Pf resistance to most existing antimalarial therapies has complicated the problem, and the emergence of resistance to artemisinin derivatives is even more concerning. It is increasingly difficult to cure malaria patients due to the limited availability of effective antimalarial drugs, resulting in an urgent need for more efficacious and affordable treatments to eradicate this disease. Herein, new nucleoside analogues including morpholino-nucleoside hybrids and thio-substituted nucleoside derivatives were prepared and evaluated for in vitro and in vivo antiparasitic activity that led a few hits especially nucleoside-thiopyranoside conjugates, which are highly effective against Pf3D7 and PfRKL-9 strains in submicromolar concentration. One adenosine derivative and four pyrimidine nucleoside analogues significantly reduced the parasite burden in mouse models infected with Plasmodium berghei ANKA. Importantly, no significant hemolysis and cytotoxicity towards human cell line (RAW) was observed for the hits, suggesting their safety profile. Preliminary research suggested that these thiosugar-nucleoside conjugates could be used to accelerate the antimalarial drug development pipeline and thus deserve further investigation.
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Dissertations / Theses on the topic "Modified Morpholino Nucleosides"

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Pattanayak, Sankha. "Design, Synthesis and Biological Applications of Modified Morpholino Nucleosides." Thesis, 2019. http://hdl.handle.net/10821/8240.

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The work embodied in this thesis entitled “Design, Synthesis and Biological Applications of Modified Morpholino Nucleosides” was initiated by the author in February, 2008 in the Department of Organic Chemistry, Indian Association for the Cultivation of Science, Kolkata under the supervision of Dr. Surajit Sinha. In Chapter 1, a general introduction of the antisense oligonucleotide field has been presented. The important members and major challenges of antisense oligos have been briefly discussed. In Chapter 2‐Part A, development of a considerably improved protocol for the synthesis of flexibly protected 7´‐hydroxy morpholino nucleoside monomers has been described. In Chapter 2‐Part B, a new methodology for the deprotection of trityl amines, which are frequency encountered in morpholino chemistry, has been presented. In Chapter 3‐Part A, synthesis of a guanidinium‐linked morpholino (GMO) pentamer has been presented. Fluorescent version of the GMO has also been prepared. In Chapter 3‐Part B, a new, mild and high yielding protocol for the synthesis of 7´‐chlorophosphoramidateactivated morpholino monomers has been described. Taking the help of the developed methodologies, a new type of photo‐caged morpholino oligomer has been synthesized. In Chapter 4, the fluorescent GMO prepared in Chapter 3‐Part A has been successfully tested in cell culture for its cellular transfection property. Encouraged by the results, the GMO was conjugated with Gli 1‐targeted morpholino antisense by click chemistry and a preliminary study on luciferase based hedgehog inhibition assay was also performed. Attention has been given to incorporate all the current references related to this contemporary area of research.<br>Research was taken care under the supervision of Prof. Surajit Sinha of the Organic Chemistry division under SCS [School of Chemical Sciences]<br>Research was carried out under CSIR fellowship
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