Relevant bibliographies by topics / Modified release dosage form

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Modified release dosage form'

Author: Grafiati
Published: 5 September 2021
Last updated: 18 February 2022

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Journal articles on the topic "Modified release dosage form"

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Bron, J., C. A. M. van Egmond, A. P. de Jong, A. Pullen, and S. W. de Jong. "Modified release dosage form of isosorbide-5-mononitrate." European Journal of Pharmaceutical Sciences 4 (September 1996): S156. http://dx.doi.org/10.1016/s0928-0987(97)86477-9.

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Murugesan, Senthilkumar, Byran Gowramma, Kaviarasan Lakshmanan, Veera Venkata Satyanarayana Reddy Karri, and Arun Radhakrishnan. "Oral Modified Drug Release Solid Dosage Form with Special Reference to Design; An Overview." Current Drug Research Reviews 12, no. 1 (2020): 16–25. http://dx.doi.org/10.2174/2589977511666191121094520.

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Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form and this oral route provides maximum active surface area among all drug delivery system for administration of various drugs. The attractiveness of these dosage forms is due to awareness of toxicity and ineffectiveness of drugs when administered by oral conventional method in the form of tablets and capsules. Usually, conventional dosage form produces wide range of fluctuation in drug concentration in the bloodstream and tissues with consequent undesirable toxicity and poor efficiency. The maintenance of concentration of drug in plasma within therapeutic index is very critical for effective treatment. These factors as well as factors such as repetitive dosing and unpredictable absorption lead to the concept of oral modified drug delivery systems like Sustained release, prolonged release, modified release, extended release. These formulations are used to identify drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. This review describes the basic information regarding modified release dosage form like designed to release their medication in controlled manner, criteria for selecting modified release dosage form and factors influencing the dosage and release pattern.
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Lee, Jaemin, Chanwoo Song, Inhwan Noh, Sangbyeong Song, and Yun-Seok Rhee. "Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms." Pharmaceutics 12, no. 8 (2020): 738. http://dx.doi.org/10.3390/pharmaceutics12080738.

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In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG) were printed by simultaneous HME and 3D deposition. Printed solid dosage forms were evaluated for their physicochemical properties, dissolution rates, and floatable behavior. Results revealed that IBF content in the solid dosage form could be individualized by adjusting the volume of solid dosage form. IBF was dispersed as amorphous state with enhanced solubility and dissolution rate in a polymer solid dosage form matrix. Due to absence of a disintegrant, sustained release of IBF from printed solid dosage forms was observed in phosphate buffer at pH 6.8. The dissolution rate of IBF was dependent on geometric properties of the solid dosage form. The dissolution rate of IBF could be modified by merging two different geometries into one solid dosage form. In this study, the 3D HME process showed high reproducibility and accuracy for preparing dosage forms. API dosage and release profile were found to be customizable by modifying or combining 3D modeling.
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Shah, Hiten J., Gunta Subbaiah, Dasharath M. Patel, and Chhagan N. Patel. "In vitro-in vivocorrelation of modified release dosage form of lamotrigine." Biopharmaceutics & Drug Disposition 30, no. 9 (2009): 524–31. http://dx.doi.org/10.1002/bdd.688.

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Pund, Atul, Atishkumar Mundada, Manoj Magar, and Abhijeet Kadam. "Recent Patents on Modified Release Oral Dosage Forms." Journal of Drug Delivery and Therapeutics 11, no. 4-S (2021): 195–211. http://dx.doi.org/10.22270/jddt.v11i4-s.4973.

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Background: Conventional oral dosage forms have limited bioavailability and frequent dosing of the drug is needed to maintain the effective therapeutic concentration in the body. This results in poor patient compliance and fluctuations in the plasma drug levels, especially in the chronic diseases and disorders.
 Objective: To overcome such problems and to enhance the efficiency and bioavailability of the drug, modified drug delivery systems such as extended release delivery systems (controlled release; sustained release) and delayed release delivery systems are developed which can prolong the release and hence action of the drug in the body.
 Methods: Through this review, we throw the light on recent patents and patent applications on modified release systems pertaining to oral dosage forms. The various free patent search databases were used to collect and analyze the information on modified release delivery systems.
 Results: Modified release systems such as extended release and delayed release delivery systems have been found to be of great significance due to their advantages over immediate release dosage forms. These systems are formulated using various approaches, different types of release controlling polymers such as natural, semisynthetic and synthetic polymers and found to avoid the limitations of conventional oral dosage forms.
 Conclusion: Modified drug release systems have potential especially, in case of the chronic diseases, mental health disorders and lifestyle diseases and disorders. These systems have unique commercial advantages which will sustain the interest of both the researchers and the pharmaceutical companies.
 Keywords: Modified release systems, extended release systems, controlled release systems, sustained release systems, delayed release systems, oral dosage forms, multilayer dosage form, multilayered tablets
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Keraliya, Rajesh A., Chirag Patel, Pranav Patel, et al. "Osmotic Drug Delivery System as a Part of Modified Release Dosage Form." ISRN Pharmaceutics 2012 (July 17, 2012): 1–9. http://dx.doi.org/10.5402/2012/528079.

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Conventional drug delivery systems are known to provide an immediate release of drug, in which one can not control the release of the drug and can not maintain effective concentration at the target site for longer time. Controlled drug delivery systems offer spatial control over the drug release. Osmotic pumps are most promising systems for controlled drug delivery. These systems are used for both oral administration and implantation. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semipermeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. Osmotic pumps release drug at a rate that is independent of the pH and hydrodynamics of the dissolution medium. The historical development of osmotic systems includes development of the Rose-Nelson pump, the Higuchi-Leeper pumps, the Alzet and Osmet systems, the elementary osmotic pump, and the push-pull system. Recent advances include development of the controlled porosity osmotic pump, and systems based on asymmetric membranes. This paper highlights the principle of osmosis, materials used for fabrication of pumps, types of pumps, advantages, disadvantages, and marketed products of this system.
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DEVI, GAYATRI, MALKIET KAUR, MANJU NAGPAL, et al. "Advanced Dosage Form Design: Role of Modified Natural Gums." Asian Journal of Chemistry 33, no. 1 (2020): 1–9. http://dx.doi.org/10.14233/ajchem.2021.22937.

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Gums are naturally occurring segments in plants, which are cheap and abundant. Natural gums and their derivatives are widely used in a pharmaceutical dosage form. These natural materials possess several advantages over synthetic ones being chemically inert, non-toxic, low cost and biodegradable. However, quick degradation in the body, poor mechanical properties and low solubility are few disadvantages. To overcome these disadvantages, natural gums are modified by applying different chemical modification procedures. The modification of gums is done via various methods such as changing functional groups of gum, cross-linking with ions, grafting with polymers, sulfation, phosphorylation and thiolation. Modification of gums results in some superior properties which can be used in drug delivery applications. For example, change in crystallinity, improved solubility, stability, and improved mechanical properties are of use in development of modified drug delivery systems. Modified gums help to achieve pH dependent delivery and sustained delivery along with improved release kinetics of the drug. Current review covers various types of modifications in general and research literature on various medications of different gums (locust bean gum, cashew gum, moringa gum, xanthan gum, etc.). The modified natural gums and their derivatives can be the prospective carriers in the controlled drug delivery of drugs.
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Babu, P. "In vitro–In vivo Correlation Studies of Modified Release Solifenacin Tablet Dosage Form." Journal of Scientific Research and Reports 3, no. 14 (2014): 1905–15. http://dx.doi.org/10.9734/jsrr/2014/9951.

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Ritschel, Wolfgang A., and Mukul A. Agrawal. "Physiologically based novel peroral modified release drug delivery system: Self-destructing hydrogel piston-pump." Ciencia e Investigación 6, no. 2 (2003): 24–29. http://dx.doi.org/10.15381/ci.v6i2.3439.

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Peroral modified drug delivery systems on the market release fue drug by either 0-order, 1º-order, square root oftime or mixed rate. This means that the drugis released mto the gastrointestinallumenin amounts being either constantper unit of time or decreasingwith time. However, physiologically absorption from the GI lumen gets slower and more difficult past the small intestme. A novel drug delivery system is described far 24 horus drug delivery which follows approximate 0-orden release throughout the small intestine, but releases increasing amounts of drug once in the colon ta compensate for increasingly more difficult absorption. Nearly constant steady state drug plasma concentrations are achieved . The novel drug delivery system is a two layered dosage form with an immediate release layer and a modified release layer. The latter ene is a hydrogel piston pump comprised of a drug core layer and a hydrogel swelling layer, embedded into a semipermeable shell by compression coating. The upper site of the shell has a release channel in the center.
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Mahaparale, PareshRamesh, and BhanudasShankarrao Kuchekar. "Development and evaluation of modified release wax matrix tablet dosage form for tramadol hydrochloride." Asian Journal of Pharmaceutics 9, no. 2 (2015): 102. http://dx.doi.org/10.4103/0973-8398.154701.

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Dissertations / Theses on the topic "Modified release dosage form"

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Ronchi, Federica. "DEVELOPMENT OF INNOVATIVE MODIFIED-RELEASE LIQUID ORAL DOSAGE FORMS." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/312267.

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Modified-release oral drug delivery dosage forms are widely used in the pharmaceutical field to overcome all the potential issues imposed by the physiological variabilities of the gastrointestinal tract as well as to maintain drug concentrations within the therapeutic window. In the market, they are available only as solid dosage forms such as capsules or tablets. The development of a liquid oral dosage form with modified-release properties has been keenly awaited. This form could increase the compliance of patients with a swallowing impairment (i.e. paediatric, older or critically ill patients) and, consequently, the efficacy of the therapeutic treatment. In this study, a new technology has been developed that consists of multi-layered particles suspended extemporaneously in a syrup. Omeprazole and budesonide have been employed as model drugs. The coating procedure was optimized to obtain a yield of minimum 90% w/w and a median diameter below 500 µm. Once the final suspension is prepared extemporaneously, it presents sufficient stability to guarantee the administration of multiple doses filled into a syrup bottle and kept for a limited storage time at room temperature (e.g. up to 10 doses to be administered within 10 days).<br>Doctorat en Sciences biomédicales et pharmaceutiques (Pharmacie)<br>info:eu-repo/semantics/nonPublished
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Klein, Sandra [Verfasser]. "Biorelevant Dissolution Test Methods for Modified Release Dosage Forms / Sandra Klein." Aachen : Shaker, 2005. http://d-nb.info/1186578025/34.

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Sujja-Areevath, Jomjai. "Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen." Thesis, Robert Gordon University, 1997. http://hdl.handle.net/10059/2347.

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Mini-matrix multiple unit dosage forms (MUDFs) of diclofenac sodium and S(+) ibuprofen have been prepared. Normal tabletting techniques were used to form the mini-matrices prior to their enclosure in hard gelatin capsules. Four natural hydrophilic gums, namely xanthan, karaya, locust bean and carrageenan gums as well as hydroxypropyl methylcellulose (HPMC) were used as the principle release-retarding agents. Various excipients - lactose, Encompress®, cellulose acetate phthalate (CAP), Veegum F® and Avicel PH101® - were added in different proportions to further modify drug release. The diclofenac sodium mini-matrices (4.5 mm in diameter) were produced by the wet granulation method. The release profiles from several encapsulated minimatrices in phosphate buffer solution (pH 7.0) showed that xanthan, karaya and locust bean gums could sustain the release of diclofenac sodium while the carrageenan gum did not produce a satisfactory sustaining effect. The rank order of decreasing swelling rate in both axial and radial dimensions was xanthan > karaya > locust bean gum and each of these gums showed almost Fickian swelling behaviour. The solvent penetration rates were consistent with the swelling rates. However, the order of decreasing drug release and erosion rates was locust bean> xanthan > karaya gum. For each of these gums, the release behaviour was anomalous indicating that both Fickian drug diffusion and polymer relaxation were involved in the release process. The dominant mechanism depended on the nature and content of the gum, as well as the stage in the dissolution period. The study involving xanthan gum showed that the diclofenac sodium release rate declined linearly with a progressive increase in the gumcontent, without changing the release behaviour. However, for high drug: xanthan gum ratio (2:1), the release kinetics changed to Super Case II. Solubility differences between the excipients did not affect the release rate, but increasing proportions of each excipient produced a faster release rate with the release mechanism changing from anomalous to Case II and then to Super Case II transport. Mini-matrices containing HPMC produced faster drug release than those containing the three natural gums. There was no synergistic effect between xanthan and locust bean gums on the release of diclofenac sodium from mini-matrices. Variation in the stirring speed (used in the dissolution apparatus) and matrix volume had little effect on drug release, whereas the pH of the dissolution medium greatly affected the release of diclofenac sodium. Following on from the studies involving diclofenac sodium, xanthan and karaya gums were used to produce mini-matrices of S(+) ibuprofen. Excipients with good compressibility characteristics such as lactose, Encompress® and Avicel PH101® were needed in the formulations. At pH 7, higher drug release rates were obtained with karaya gum (Super Case II mechanism) compared with xanthan gum (anomalous behaviour). Solubility differences between the excipients slightly affected the release rate. Compression forces (11 - 26 kN) slightly affected the crushing strength. The minimatrices were relatively stable to variation in temperature (5 - 37°C) and relative humidity (10 - 75%) over a 2 month time period. These studies have shown that near zero-order release of diclofenac sodium and S(+) ibuprofen can be achieved using encapsulated mini-matrices formulations. The release mechanisms and release rates can be adjusted by variation of the type and content of gums and/or excipients.
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Tandt, Ludo Alfons Germaan Luc. "The evaluation of indomethacin and theophylline oral controlled/modified-release dosage forms in vitro-in vivo correlations." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1003272.

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Over the past few decades many researchers have investigated the utility of in vitro - in vivo correlations for the assessment of dosage forms. These investigations are, however, dependent on reproducible dissolution data and well conducted biostudies in order to establish meaningful and robust correlations. Despite the fact that the establishment of such correlations is perhaps idealistic, considerable interest has still been shown in this area of research. Various Controlled/Modified Release Dosage Forms (CMRD's) of theophylline, a weakly basic drug, and indomethacin, a weakly acidic drug, were assessed in order to establish in vitro - in vivo correlations. Dissolution rate studies were carried out using either the USP basket or paddle apparatus. The dissolution rate studies were conducted in a range of dissolution media of varying pH. Bioavailability studies were conducted on the dosage forms used by the Biopharmaceutics Research Institute at Rhodes University. The results of these biostudies were kindly made available for use in this research project. Type A correlations were established using a mathematical simulation process whereby expected in vivo responses are simulated and compared to actual profiles obtained for the dosage forms. In order to perform the simulations the dissolution rate profiles were stripped and using linear regression and the methods of residuals the dissolution rate order and the relevant dissolution rates were obtained. The results of the s imulations indicated that the in vivo serum concentration-time curves could be accurately predicted for the theophylline dosage forms but to a lesser extent, for the indomethacin formulations. The dissolution rate studies indicated that the paddle method is a suitable method for dissolution rate studies of theophylline CMRD's, although it appeared that the optimum pH of the dissolution medium was formulation dependent. Dissolution rate studies conducted on indomethacin formulations indicated that the USP specified basket method for extended-release indomethacin formulations was not able to distinguish between two formulations which exhibited different in vivo profiles. The conversion to the paddle method was, however, able to highlight the differences between these formulations. The use of three dimensional topographs to depict dissolution rate profiles was demonstrated for formulations of both theophylline and indomethacin. The topographs enabled the successful differentiation between bioinequivalent formulations. The dissolution rate profiles were also fitted to the Wei bull equation and the parameters obtained from this were compared to the Weibull parameters obtained from the in vivo absorption plots obtained using the Wagner-Nelson method. The results indicated that the Weibull function was suitable to describe both the in vivo and in vitro data. The following recommendations for the preformulation dissolution studies of weakly acidic and weakly basic drugs are proposed. The dissolution rate studies of weakly acid drugs, such as indomethacin, should be carried out over a range of pH utilising the paddle apparatus. Three dimensional topographs based on the dissolution data should be constructed and used as a comparative tool for different formulations. Based on these comparisons the appropriate formulation can then be selected for a pilot scale in vivo bioavailability study. The dissolution rate studies of weakly basic drugs, such as theophylline, should be carried out over a range of pH utilising the paddle apparatus. The dissolution data should then be used to simulate the expected in vivo profile and on this basis the appropriate formulation selected for a pilot scale bioavailability study. The above approach to the preformulation studies of new CMRO's would allow for the more careful selection of new dosage forms and could thus eliminate costly and unnecessary bioavailability studies performed on inferior formulations.
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Raiwa, Araya [Verfasser]. "Formulation development strategies for oral extended release dosage form / Araya Raiwa." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025490363/34.

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Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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Owaisat, Suzan. "A novel oral dosage form with drug independent formulation and variable controlled release." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/342831.

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Pharmaceutical Sciences<br>Ph.D.<br>A unique dosage form which uses a hydrophilic polymer was developed to provide for a predicable release of several drugs. This drug release could be optimized for controlled release using erosion. It can also be designed to release drug utilizing electrochemical processes. The accuracy of drug delivery in terms of dose and timing is of utmost importance for the patient’s health status and compliance. A well-designed drug delivery technology offers many advantages to the patient. These advantages include: reduction in dose frequency, reduction of drug side effects, reduced unwanted fluctuations in circulating drug levels, and a more uniform effect of the drug over time. The practice of drug delivery has been dramatically developed in the last decade including electronic controlled release innovative dosage forms. In this study the iontophoretic flux of ibuprofen was investigated using side- by-side diffusion cells. Iontophoresis is the process where electric current is applied to enhance transportation of drugs across the skin. The pH change was found to be an important factor in increasing the diffusion of the drug. The principle of using electric current as a driving force to control the drug release was initially demonstrated on an initial setup. Subsequently, a calcium binding polymer was the hydrogel used as a matrix to develop a new electric oral dosage form. The calcium binding polymer is produced in different forms. The production process of these forms suffers several limitations. In order to apply electric current in a practical way to the calcium binding polymer matrix a novel method was developed. The novel method also allowed for addressing the limitations related to the production process of the conventional dosage form made with this polymer. More uniform gel tablets in shape and size were produced. Different formulations were developed. Ibuprofen was the model drug initially used to investigate the factors that affected the release profiles of these tablets. A two-level, three-factor statistical design of experiments (DOE) was performed to evaluate the effect of those factors on certain responses. These responses included the release rate, time needed to release 80% of the model drug, and lag-time. A new formulation with certain adjuvants was developed. This formulation had the ability to release different kinds of drugs in a uniform release rate. A fail-safe tablet that can only release less than 20% of the drug in 24 hours was developed. The drug release was initiated only when the electric current was applied. This new electric dosage form was aimed to overcome the disadvantages related to conventional dosage forms such as the inability to supply drugs on demand.<br>Temple University--Theses
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Dogra, Sanjeev. "A Chitosan–Polymer Hydrogel Bead System For A Metformin HCl Controlled Release Oral Dosage Form." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1303179716.

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LALWANI, DARSHAN NARENDRA. "An oral dosage form of ceftriaxone sodium using enteric coated sustained release calcium alginate beads." University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1430403186.

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Kindgen, Sarah M. [Verfasser]. "Hydrodynamics and solid dosage form disintegration/dissolution : immediate release tablets and novel in situ polyelectrolyte gastroretentive drug delivery systems / Sarah M. Kindgen." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2015. http://d-nb.info/1225749581/34.

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Books on the topic "Modified release dosage form"

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Tiwary, Ashok Kumar. Chitosan: Modifications and applications in dosage form design. Nova Science Publishers, 2012.

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Controlled Release Dosage Form Design. Informa Healthcare, 1999.

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Towlson, Jon. Close Encounters of the Third Kind. Liverpool University Press, 2016. http://dx.doi.org/10.3828/liverpool/9781911325079.001.0001.

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For many, Close Encounters of the Third Kind (CE3K) is not so much a movie as a religious experience. On its release in 1977, CE3K virtually redefined the science-fiction film, shifting it away from spaceships, laser guns, and bug-eyed monsters into a modified form of science fiction that John Wyndham once called ‘logical fantasy’. What would it be like if extra-terrestrials made contact with people on Earth? How would it feel? Like 2001: A Space Odyssey (1968), Steven Spielberg's primary inspiration, CE3K is concerned with mankind's evolution towards the stars, towards a state of transcendence. But Spielberg's vision hinges not so much on cool scientific intellect being the key to our next stage of evolution, as on the necessary development of emotional intelligence. To that end, we must regain our childlike curiosity for what lies beyond the skies, we must recover our capacity to experience wonder. Intensity of emotion is inherent to the film's meaning, and the aim of this book is to explore this in detail. Along the way, the book delves into the film's production history, explores Spielberg's remarkable cinematic realization of the film (including a comparison study of the three different release versions), and considers in detail how CE3K fits into the Spielberg oeuvre.
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Book chapters on the topic "Modified release dosage form"

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Fassihi, Reza. "Modified-Release Delivery Systems." In Pharmaceutical Dosage Forms. CRC Press, 2017. http://dx.doi.org/10.1201/9781315111896-12.

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Brunaugh, Ashlee D., Hugh D. C. Smyth, and Robert O. Williams III. "Modified Release Solid Oral Dosage Forms." In AAPS Introductions in the Pharmaceutical Sciences. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-31745-4_4.

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Piscitelli, Deborah A., and David Young. "Setting Dissolution Specifications for Modified-Release Dosage Forms." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-6036-0_13.

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Jena, Goutam Kumar, Ch Niranjan Patra, Mahfoozur Rahman, and Sarwar Beg. "Recent Advances in the Development of Modified Release Oral Dosage Forms." In Pharmaceutical Drug Product Development and Process Optimization. Apple Academic Press, 2020. http://dx.doi.org/10.1201/9780367821678-4.

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Heald, Donald L., John A. Ziemniak, and Ian R. Wilding. "The Gastrointestinal Transit and Systemic Absorption of Diltiazem HCL from a Modified Release Dosage Form." In Nuclear Imaging in Drug Discovery, Development, and Approval. Birkhäuser Boston, 1993. http://dx.doi.org/10.1007/978-1-4684-6808-3_16.

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MacDougall, Fiona, Lee Ann Hodges, and Howard N. E. Stevens. "Evolving Biopharmaceutics Perspectives for Hydrophilic Matrix Tablets: Dosage Form–Food Interactions and Dosage Form Gastrointestinal Tract Interactions." In Hydrophilic Matrix Tablets for Oral Controlled Release. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1519-4_12.

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Piel, G., B. Evrard, T. Van Hees, C. Fernandez Del Pozo, and L. Delattre. "Development of a Sustained Release Dosage form Containing a Diclofenac-Cyclodextrin Inclusion Complex." In Proceedings of the Ninth International Symposium on Cyclodextrins. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4681-4_51.

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Villar-López, M. E., F. Otero-Espinar, and J. Blanco-Méndez. "Preparation by Extrusion/Spheronization of Triamcinolone / ß-Cyclodextrin Pellets as a Fast Release Dosage Form." In Proceedings of the Ninth International Symposium on Cyclodextrins. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4681-4_115.

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"The Zydis Oral Fast-Dissolving Dosage Form." In Modified-Release Drug Delivery Technology. CRC Press, 2002. http://dx.doi.org/10.1201/9780203910337-18.

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"Tableting of Multiparticulate Modified Release Systems." In Pharmaceutical Dosage Forms - Tablets. CRC Press, 2016. http://dx.doi.org/10.1201/b15115-44.

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Conference papers on the topic "Modified release dosage form"

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Kotlyarova, Anastasiya A., Andrey Yu Letyagin, Tatiana G. Tolstikova, Lybov N. Rachkovskaya та Tatyana V. Popova. "Comparative Pharmacokinetic Analysis of а Novel Prolonged Release Dosage Form of Lithium Citrate in Mice". У 2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB). IEEE, 2018. http://dx.doi.org/10.1109/csgb.2018.8544827.

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Kotlyarova, A. A., A. Yu Letyagin, T. V. Popova, L. N. Rachkovskaya, and T. G. Tolstikova. "Preclinical investigation of the pharmacokinetic of a novel prolonged release dosage form of lithium citrate." In 2017 International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON). IEEE, 2017. http://dx.doi.org/10.1109/sibircon.2017.8109949.

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Kapnisis, Konstantinos, Polyvios Eleftheriou, George Lapathitis, et al. "Surface Modified Nitinol Stents Release Metal Ions in Blood." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14244.

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Intravascular nitinol stents are used in the treatment of atherosclerosis and intracranial aneurysms. Despite the unique physical properties of shape memory and superelasticity, the chemical composition of NiTi has raised concerns due to the presence of nickel ions within the alloy which can have adverse effects on human health. Currently, stents are manufactured from corrosion resistant alloys which form protective titanium oxide films, insulating the bulk material from the corrosive physiologic fluid. However, nanometer thick regions of oxides are lost at locations of high strain due to significant bending, micromotion between overlapping stents or local calcification1‐2. Recent studies have revealed that some stents undergo corrosion in vivo, with significant release of metallic ions into surrounding tissues3–4. In this project, a range of techniques has been employed to modify the surface of miniature NiTi stents in order to mimic in vivo corrosion and correlate the amount of nickel ions released with the findings in explanted tissue.
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Manna, Soumyarwit, James J. Augsburger, Zelia M. Correa, Julio A. Landero, and Rupak K. Banerjee. "Influence of Hydrophobic Surface Modification of Chitosan Based Methotrexate (MTX) Micro Implants to Treat Intraocular Lymphoma." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14414.

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Primary intraocular lymphoma (PIOL) is a rare form of lymphoma which is encountered in ocular oncology practice. Most preferred treatment has been intravitreal MTX injections which do not have a long lasting chemotherapeutic effect due to rapid elimination of the drug. In this study, chitosan (CS) and polylactic acid (PLA) based intraocular implants are fabricated for different MTX loadings (10%, 25% and 40% w/w). The implants administer a therapeutic dosage of 0.2–2.0 μg/day of MTX over a period of a month. PLA coated CS-MTX implants can be used for sustained release of MTX, thereby improving the treatment of PIOL.
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Nguyen, Crystal, Daniel Volpe, William Wilson, Mansour Zenouzi, and Jason Avent. "Efficiency Experiments on Modified Dye Sensitized Solar Cells." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68773.

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Dye Sensitized Solar Cells (DSSC) is a relatively new form of solar panels which use a photo reactive dye and electrolytic cell to capture sunlight and turn it into electricity. The efficiency of DSSCs is about 10% but they are much less expensive to produce than silicon solar cells. The carbon dioxide release from DSSC manufacture is much less than a silicon solar cell, so DSSCs pay back their greenhouse gas emissions rapidly, while many silicon panels may never pay back the pollution they require to manufacture. Because of greater efficiency, silicon solar cells still produce power more cheaply than DSSC. Slight improvements to efficiency or reduction in cost would make these solar panels a more cost effective solution for photovoltaic power. A standard DSSC was built and compared to a modified version using a graphite layer instead of platinum. Surprisingly, the graphite panel outperformed the platinum panel. This is thought to be a result of inexperienced manufacturing. Recommendations for improvements for the experiment are outlined.
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NIEMIEC, Marcin, Monika TABAK, Łukasz PALUCH, and Monika KOMOROWSKA. "ASSESSMENT OF PRODUCTIVE AND ENVIRONMENTAL EFFICIENCY OF SLOW-RELEASE FERTILIZERS IN INTEGRATED PRODUCTION OF NAPA CABBAGE DEPENDING ON APPLICATION METHOD." In RURAL DEVELOPMENT. Aleksandras Stulginskis University, 2018. http://dx.doi.org/10.15544/rd.2017.079.

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The study aimed to assess the suitability of slow-release fertilizers in cultivation of napa cabbage in the integrated production system. The objective was realized on the basis of a strict field experiment set up on soil with granulometric composition of light loam. The dose of fertilizer was the first experimental factor, and the fertilizer application was the second factor. The slow-acting fertilizer was applied under each plant during planting of seedlings and in the second variant. The fertilizer was applied in the row, about 5 cm under the seedling root level. On the basis of the results obtained in the experiments, the indices showing nitrogen fertilization efficiency were calculated Fertilization significantly modified the quantity of obtained yield. In the control, without mineral fertilization, the crop yield was 23.32 Mg · ha-1. The largest yield was 52.27 Mg · ha-1. Larger yields and more advantageous productive and environmental efficiency were obtained in objects with row application of fertilizer. The most advantageous agronomic efficiency and nitrogen recovery efficiency were obtained in the combination of 400 kg · ha-1 of slow-acting fertilizer with traditional supplementary PK fertilizers in the case of point application of fertilizers. In the case of row fertilizer application, it is possible to use 50% more of the fertilizer dose without compromising the quality of the crop. Higher doses of free-acting fertilizers increased the standard deviation of the mass of cabbage, which is not desirable for production. The results show that under conditions of low mineral content in the soil, the slow-acting fertilizers can be used at a low level.
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Bårzu, T., P. Molho, R. Cariou, G. Tobelem, and J. Caen. "HEPARIN BINDING TO ENDOTHELIAL CELLS POTENTIATES THROMBINSTIMULATED PGI2 PRoDUCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642840.

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We studied the consequences of hepari n (H) binding to endothel iaI cells (EC) on their basal and thrombin-stimulated PGI2 production. Primary cultures of human umbilical vein EC were incubated with different H concentrations, in serum free medium for 5 hrs. The amount of 6-keto-pGF1α was measured in the medium after 5 hrs with an enzyme-linked inmunoassay. At all concentrations used (0.75 to 75 μg/ml) H did not alter the 5-hour basal production of PGI2 (control, 10.1 α 1.4 ng/106 cells; H 15 μg/m1 ; 10.8 ± 2.7 ng/106 cells). Basal or thrombin (0.1 U/m])-rtimulated (10 min) pGI2 production was then determined using EC bearing only bound heparin. The low, unstimulated PGI2 release (0.412 ± 0.04 ng/106 cells) was not significantly changed in the presence of bound H, but the thrombin-stimulated release was potentiated.The KD for H binding to EC is 2.5 μg/ml. Thus at 3 μg/ml, half maximal saturation of binding sites and maximal potentiation of thrombin action were achieved. This concentration of bound H shifted the dose-response curve of thrombin induced PGI2 production to the left. Similar effect was obtained with half maximal saturating concentration of low molecular weight H (CY 222). Neither arachinodate nor LC4-induced PGI2 release were modified by H binding to EC, suggesting that potentiation is specific to thrombin. Since bound H was shown to not modify the high affinity thrombin binding to EC, the potentiating effect of bound H could related rather to interference with the specific mechanism of thrombin-stimulation of PGI2 production.
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Saulnier, George J., K. Patrick Lee, Donald A. Kalinich, S. David Sevougian, and Jerry A. McNeish. "Total System Performance Assessment Model for the Final Environmental Impact Statement for the Potential High-Level Nuclear Waste Repository at Yucca Mountain." In 10th International Conference on Nuclear Engineering. ASMEDC, 2002. http://dx.doi.org/10.1115/icone10-22322.

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The total-system performance assessment (TSPA) model for the final environmental impact statement (FEIS) for the potential high-level nuclear-waste repository at Yucca Mountain, Nevada was developed from a series of analyses and model studies of the Yucca Mountain site. The U.S. Department of Energy (DOE) has recommended the Yucca Mountain, Nevada site for the potential development of a geologic repository for the disposal of high-level radioactive waste and spent nuclear fuel. In May 2001, the DOE released the Yucca Mountain Science and Engineering Report (S&amp;ER) for public review and comment. The S&amp;ER summarizes more than 20 years of scientific and engineering studies supporting the site recommendation (SR). Following internal reviews of the S&amp;ER and other documents, the DOE performed supplemental analyses of uncertainty in support of the SR as summarized in the Supplemental Science and Performance Analysis (SSPA) reports [2, 3]. The SSPA (1) provided insights into the impact of new scientific data and improved models and (2) evaluated a range of thermal operating modes and their effect on the predicted performance of a potential repository. The various updated component models for the SSPA resulted in a modified TSPA model, referred to as the supplemental TSPA model or SSPA TSPA model capturing the combined effects of the alternative model representations on system performance. The SSPA TSPA model was the basis for analyses for the FEIS for the Yucca Mountain site. However, after completion of the SSPA, the U.S. Environmental Protection Agency (EPA) released its final radiation-protection standards for the potential repository at Yucca Mountain (40 CFR Part 197). Compliance with the regulation required modification of several of the component models (e.g., the biosphere transport model and the saturated-zone transport model) in order to evaluate repository performance against the new standards. These changes were incorporated into the SSPA TSPA model. The resulting FEIS TSPA model, known as the “integrated TSPA model,” was used to perform the calculations presented in this report. The results of calculations using the FEIS TSPA model under a non-disruptive scenario, show that the potential disposal of commercial and DOE waste at a Yucca Mountain repository would not produce releases to the environment that would exceed the regulatory standards promulgated in the EPA Final Rule 10 CFR 197 and the NRC Final Rule 10 CFR 63 for both individual protection and groundwater protection. The analyses also show that both the high and low-temperature operating modes result in similar mean annual dose to the reasonably maximally exposed individual (RMEI). Further, the analyses show that consideration of intrusive and extrusive igneous events, human intrusion, or inclusion of the potential inventory of all radioactive material in the commercial and DOE inventory would not exceed those published standards.
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Pan, Feng, John Lee, Alex Di Sciullo Jones, and Adam Huang. "Improved Micro-Patterning of Soft-Polymers and Elastomers Using Conformally Coated Omni-Coat Nanofilms." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67843.

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This paper describes the basic Direct Polymer Patterning On Substrate Technique (DPPOST) process and a modified process currently under development to provide higher robustness in the fabrication process, with the goal of achieving near 100% patterning yields. The patterning of soft-polymers and elastomers has gained interest in the last decade as the material of choice for lab-on-the chip applications; i.e., forming micro-fluidic and bio-reactor chambers. Recently, a lithographically compatible patterning method for soft-polymers and elastomers have been demonstrated by using SU-8® hard polymer resists as robust lift-off molds. This patterning technology, DPPOST, has the ability to form a wide range of structural features found in MEMS, from tens of millimeter structures to micrometer level resolutions. It has been used to embed nano-particles, such as carbon-black (∼45nm mean radius) and metal particles, and allows lithographic alignment of electrodes on micro-fluidic channels previously not possible with soft-lithography fabricated PDMS devices. The modified-DPPOST process uses conformal coating of Omnicoat™ nano-films to provide a barrier between the SU-8® and the patterned polymer, hence reducing stiction during the release process.
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Strobio Chen, Lin, Thomas Steinbacher, Camilo Silva, and Wolfgang Polifke. "On Generation of Entropy Waves by a Premixed Flame." In ASME Turbo Expo 2016: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/gt2016-57026.

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It is understood that so-called “entropy waves” can contribute to combustion noise and play a role in thermoacoustic instabilities in combustion chambers. The prevalent description of entropy waves generation regards the flame front as a source of heat at rest. Such a model leads — in its simplest form — to an entropy source term that depends exclusively on the unsteady response of the heat release rate and upstream velocity perturbations. However, in the case of a perfectly premixed flame, which has a constant and homogeneous fuel / air ratio and thus constant temperature of combustion products, generation of entropy waves (i.e. temperature inhomogeneities) across the flame is not expected. The present study analyzes and resolves this inconsistency, and proposes a modified version of the quasi 1-D jump relations, which regards the flame as a moving discontinuity, instead of a source at rest. It is shown that by giving up the hypothesis of a flame at rest, the entropy source term is related upto leading order in Mach number to changes in equivalence ratio only. To supplement the analytical results, numerical simulations of a Bunsen-type 2D premixed flame are analysed, with a focus on the correlations between surface area, heat release and position of the flame on the one hand, and entropy fluctuations downstream of the flame on the other. Both perfectly premixed as well as flames with fluctuating equivalence ratio are considered.
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