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Dissertations / Theses on the topic 'Modified release dosage form'

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Published: 5 September 2021

Last updated: 18 February 2022

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1

Ronchi, Federica. "DEVELOPMENT OF INNOVATIVE MODIFIED-RELEASE LIQUID ORAL DOSAGE FORMS." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/312267.

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Modified-release oral drug delivery dosage forms are widely used in the pharmaceutical field to overcome all the potential issues imposed by the physiological variabilities of the gastrointestinal tract as well as to maintain drug concentrations within the therapeutic window. In the market, they are available only as solid dosage forms such as capsules or tablets. The development of a liquid oral dosage form with modified-release properties has been keenly awaited. This form could increase the compliance of patients with a swallowing impairment (i.e. paediatric, older or critically ill patient

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2

Klein, Sandra [Verfasser]. "Biorelevant Dissolution Test Methods for Modified Release Dosage Forms / Sandra Klein." Aachen : Shaker, 2005. http://d-nb.info/1186578025/34.

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3

Sujja-Areevath, Jomjai. "Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen." Thesis, Robert Gordon University, 1997. http://hdl.handle.net/10059/2347.

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Mini-matrix multiple unit dosage forms (MUDFs) of diclofenac sodium and S(+) ibuprofen have been prepared. Normal tabletting techniques were used to form the mini-matrices prior to their enclosure in hard gelatin capsules. Four natural hydrophilic gums, namely xanthan, karaya, locust bean and carrageenan gums as well as hydroxypropyl methylcellulose (HPMC) were used as the principle release-retarding agents. Various excipients - lactose, Encompress®, cellulose acetate phthalate (CAP), Veegum F® and Avicel PH101® - were added in different proportions to further modify drug release. The diclofen

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4

Tandt, Ludo Alfons Germaan Luc. "The evaluation of indomethacin and theophylline oral controlled/modified-release dosage forms in vitro-in vivo correlations." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1003272.

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Over the past few decades many researchers have investigated the utility of in vitro - in vivo correlations for the assessment of dosage forms. These investigations are, however, dependent on reproducible dissolution data and well conducted biostudies in order to establish meaningful and robust correlations. Despite the fact that the establishment of such correlations is perhaps idealistic, considerable interest has still been shown in this area of research. Various Controlled/Modified Release Dosage Forms (CMRD's) of theophylline, a weakly basic drug, and indomethacin, a weakly acidic drug, w

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5

Raiwa, Araya [Verfasser]. "Formulation development strategies for oral extended release dosage form / Araya Raiwa." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025490363/34.

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6

Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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7

Owaisat, Suzan. "A novel oral dosage form with drug independent formulation and variable controlled release." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/342831.

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Pharmaceutical Sciences<br>Ph.D.<br>A unique dosage form which uses a hydrophilic polymer was developed to provide for a predicable release of several drugs. This drug release could be optimized for controlled release using erosion. It can also be designed to release drug utilizing electrochemical processes. The accuracy of drug delivery in terms of dose and timing is of utmost importance for the patient’s health status and compliance. A well-designed drug delivery technology offers many advantages to the patient. These advantages include: reduction in dose frequency, reduction of drug side ef

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8

Dogra, Sanjeev. "A Chitosan–Polymer Hydrogel Bead System For A Metformin HCl Controlled Release Oral Dosage Form." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1303179716.

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9

LALWANI, DARSHAN NARENDRA. "An oral dosage form of ceftriaxone sodium using enteric coated sustained release calcium alginate beads." University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1430403186.

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10

Kindgen, Sarah M. [Verfasser]. "Hydrodynamics and solid dosage form disintegration/dissolution : immediate release tablets and novel in situ polyelectrolyte gastroretentive drug delivery systems / Sarah M. Kindgen." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2015. http://d-nb.info/1225749581/34.

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11

Lee, Tak-yee. "Part 1: Computer aided dosage form design: theory and applications. Part 2: Kinetics and mechanism of captopril oxidation in aqueous solutions under controlled oxygen partial pressure /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266011224445.

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12

Pavurala, Naresh. "Oral Drug Delivery -- Molecular Design and Transport Modeling." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/53505.

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One of the major challenges faced by the pharmaceutical industry is to accelerate the product innovation process and reduce the time-to-market for new drug developments. This involves billions of dollars of investment due to the large amount of experimentation and validation processes involved. A computational modeling approach, which could explore the design space rapidly, reduce uncertainty and make better, faster and safer decisions, fits into the overall goal and complements the product development process. Our research focuses on the early preclinical stage of the drug development process

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13

Forsgren, Johan. "Functional Ceramics in Biomedical Applications : On the Use of Ceramics for Controlled Drug Release and Targeted Cell Stimulation." Doctoral thesis, Uppsala universitet, Nanoteknologi och funktionella material, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132377.

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Ceramics are distinguished from metals and polymers by their inorganic nature and lack of metallic properties. They can be highly crystalline to amorphous, and their physical and chemical properties can vary widely. Ceramics can, for instance, be made to resemble the mineral phase in bone and are therefore an excellent substitute for damaged hard tissue. They can also be made porous, surface active, chemically inert, mechanically strong, optically transparent or biologically resorbable, and all these properties are of interest in the development of new materials intended for a wide variety of

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14

Pereira, Camelo Sarah Regina. "Encapsulation de molécules hydrophobes par des structures bi-gels générées par prilling : relation structure-propriétés." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2015. http://www.theses.fr/2015EMAC0002/document.

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Ce travail de thèse s’articule autour de la génération et de la caractérisation de capsules d’organo-hydrogel ou simplement bi-gels, obtenues par la technologie du prilling et destinées à la délivrance contrôlée d’un principe actif (P.A), après administration par voie orale. L’Efavirenz (EFV), un antirétroviral utilisé dans le traitement du VIH/Sida, a été le P.A utilisé comme modèle de molécule de faible solubilité dans l’eau. Il a été dissous dans l’organogel composé d’huile de tournesol et d’acide 12-hydroxystéarique (12-HSA). L’organogel a été caractérisé par sa température de transition d

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15

Meslard, Jean-Claude. "Immobilisation temporaire de medicaments par des liaisons hydrolysables sur des polymeres biocompatibles : application a l'ophtalmologie." Paris 6, 1988. http://www.theses.fr/1988PA066417.

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L'objectif est l'immobilisation reversible de medicaments (chloramphenicol, indometacine) au sein de lentilles de contact hydrophiles permettant une liberation lente et continue lors de leur adaptation sur des yeux malades

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16

Bakhouya, Abderrahmane. "Etude du processus de libération des principes actifs à partir de formes galéniques lipidiques à matrice de gélucire : modélisation de la pénétration tissulaire de la ciprofloxacine." Saint-Etienne, 1996. http://www.theses.fr/1996STET4013.

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Les formes galéniques matricielles, à matrice lipidique tels que les gélucires, permettent une libération contrôlée du principe actif. Ces matrices peuvent subir une érosion plus ou moins prononcée selon la nature de l'excipient. Lorsque le gélucire est hydrophile, le processus de libération s'effectue par érosion de la forme galénique. Avec un gélucire lipophile, le processus de libération est contrôlé par diffusion. Pour simuler le contrôle de la libération par érosion dans l'organisme, nous avons construit un modèle numérique qui tient compte de tous les facteurs ; notamment, les trois stad

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17

Berrabah, Mohammed. "Etude analytique de nanocapsules renfermant des substances de nature hydrophile. Influence de la vectorisation sur le métabolisme." Rouen, 1995. http://www.theses.fr/1995ROUES008.

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Les nouvelles formes galéniques permettant la vectorisation des principes actifs à l'état de suspension de nanocapsules peuvent entraîner des modifications du métabolisme des molécules ainsi administrées. Les nanocapsules étudiées ici sont constituées d'une paroi de polycaprolactone renfermant le benzoate de benzyle dans lequel est dissous le principe actif. Un contrôle analytique par CPG-SM couplée a été mis au point et validé. Il permet grâce à une méthode d'extraction différentielle, d'identifier le principe actif resté en solution, celui qui est encapsulé et celui qui se trouve plus au moi

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18

Cardoso, Sara Sofia Dias. "Generic drug product development of a modified-release oral dosage form." Master's thesis, 2018. http://hdl.handle.net/10316/84678.

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Dissertação de Mestrado em Tecnologias do Medicamento apresentada à Faculdade de Farmácia<br>O presente projeto visa o desenvolvimento de um medicamento genérico de libertação prolongada para administração oral, sob a forma farmacêutica de comprimidos não revestidos. O projeto foi desenvolvido na Bluepharma Indústria Farmacêutica, S.A. e foi referido como Blue055, de acordo com a política de confidencialidade da empresa.Os principais objetivos do projeto foram desenvolver uma formulação, um processo de fabrico e produzir protótipos capazes de mimetizar o comportamento in vitro do produto de re

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19

Wang, Kuo-Cheng, and 王國正. "An investigation of the use of modified-release dosage forms in patients with nasogastric tube in Taiwan." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/a86s9j.

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20

Martins, Ana Catarina Maximino. "Relatório de Estágio e Monografia intitulada"Formas farmacêuticas orais de libertação modificada: uma análise dos resultados dos testes de dissolução"." Master's thesis, 2020. http://hdl.handle.net/10316/93017.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Atualmente a indústria farmacêutica passou por uma grande revolução, nomeadamente devido ao avanço do conhecimento em tecnologia farmacêutica que permitiu a criação de novas formas farmacêuticas melhor adaptadas aos doentes e às suas necessidades promovendo uma melhoria da sua qualidade de vida. Com o desenvolvimento tecnologia da indústria farmacêutica e com a criação de novas formas farmacêuticas com perfis de dissolução e libertação mais complexos, também foi necessário um avanço rela

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21

涂祖強. "The study of Acetylsalicylic acid slow release dosage form." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/11743423245045571748.

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22

BAO, LI-HENG, and 鮑力恆. "Design and Development of Chlorpheniramine controlled -release Dosage form." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/26882967239551292291.

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碩士<br>國防醫學院<br>藥學研究所<br>78<br>Chlorpheniramine 為臨床上最常用H1-接受器組織胺的拮抗劑，通常一日需服用3-4 次，對病人使用上非常不便，本論文即從事將Chlorpheniramine maleate裝成控制釋出顆粒劑型的研究，以期減少服藥次數，進而改善治療效果。此外本研究已發展出一可同時測定chlorpheniramine、pseudoephedrine及第二代抗組織胺，terfenadine的分析方法，可以成功地應用於此在藥物在血中的分析。在裝劑研究方面，以還心流動造粒機從事控制釋出劑型的裝造。控釋顆粒於體外的評估除依據美國藥典二十一版的遠見規定進行溶離度試驗外，并利用自行開發成功的擬胃腸道酸齡度的體外溶離裝置，配合藥物在胃腸道的排空時間，進行模擬藥物在人體胃腸道中的溶離試驗。經由一述兩種溶離試驗的評估顯示，控釋顆粒中已有多批在體外呈現控釋特性。同時藥物自控釋顆粒中釋出的速率與量，并不受酸齡值的影響而改變。其中HPMCP

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23

Ge, Yan 1962. "Development and evaluation of a sustained release amoxicillin dosage form." Thesis, 1994. http://hdl.handle.net/1957/35255.

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24

Yang, Wen-Chiech, and 楊文潔. "Preparation and Evaluation of Propranolol Hydrochloride Extended Release Dosage Form." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/16700312992971239125.

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碩士<br>高雄醫學大學<br>藥學研究所<br>91<br>英文摘要 Abstract The purpose of this study was to design and develop a Propranolol extended-release matrices tablets. The effects of viscosity of HPMC including 4000 cps, 30000 cps, 15000 cps, 100000 cps, Drug/HPMC ratio（5/1, 3/1, 1/1.5,）, amount of Avicel, lubricant level （0.5 %、1 %、2 %）, compaction pressure （100 kg/cm2, 130 kg/cm2, 200 kg/cm2）and so on were evaluated by the in vitro dissolution test. In addition, the response surface methodology (RSM) and multiple responses optimization utilizing quadratic polynomial eq

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25

Sung, Chia-Hung, and 宋嘉鴻. "Preparation and Evaluation of Nicardipine Hydrochloride Sustained Release Dosage Form." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/37384242568638005980.

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碩士<br>高雄醫學大學<br>藥學研究所<br>90<br>Controlled release may be defined as a technique by which drug are made available to a target at a rate and duration to produce a desirable therapeutic effect. Among the advantages of this technique are to achieve rapid onset and then maintain therapeutic drug level, to reduce dosing frequency, fluctuation in drug level, total amount of drug used and inconvenience to patient and also increase patient compliance. In the study solid dispersion with solvent method was applied with Eudragit RS 100 and Eudragit RL 100 as carriers to prepare nicardipine soli

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26

Saccás, João André dos Santos. "Development of multiple-units dosage form for prolonged drug release." Master's thesis, 2016. http://hdl.handle.net/10451/34576.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Ao longo dos últimos anos, o interesse por formas de dosagem múltipla na área farmacêutica tem vindo a aumentar devido às suas vantagens tecnológicas e terapêuticas. Os pellets farmacêuticos podem ser produzidos por uma grande variedade de métodos, no entanto o mais comum é por extrusão-esferonização. As prensas de matriz plana são um tipo específico de extrusores que são geralmente usadas noutras indústrias. Devido às suas elevadas capacidades, custos reduzidos, produção elevad

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27

Su, Huei Ling, and 蘇慧玲. "Development of Nifedipin Pellet Dosage Form and Development of Matrix Materials for Direct Compression of Controlled Release Dosage Form." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/53999187330499659708.

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28

Kaul, Dilip. "Development of a sustained release dosage form for an iron chelator." 1991. http://hdl.handle.net/1993/17343.

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29

Huang, Hsiao-Feng, and 黃曉鳳. "A Study on the Controlled Release Pellets Dosage Form of Ketoprofen." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/06975865194382617797.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>92<br>The objective of this study was to evaluate the feasibility of the preparation of ketoprofen pellets by extrusion-spheronization method using Taguchi orthogonal and 23 full factorial experiment design. According to the ANOVA test, the results showed that amount of water content and amount of binder content have a significant effect on the yield, while the important variables which influence the roundness of pellets seem to the spheronization speed. Successively, the optimized pellets were coated with an ethylcellulose pseudolatex preparation (Surelease®) in a

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30

Huang, Mao-lin, and 黃茂淋. "A Study on the Controlled Release Pellets Dosage Form of Dipyridamole." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/47532467534013876651.

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碩士<br>國立中正大學<br>化學工程所<br>96<br>Abstract The thesis used effervescent compounds (tartaric acid) treats as the control drug release factor, carries on the powder layer technology proceed drug layer and membrane coating manufacture multilayer membrane controls releases pellets; Used the differential scanning calorimeter (DSC) and the Fourier transform infrared spectrometer (FTIR) carries on the qualitative analysis, the microscope proceed to each differ layer appearance analysis, and the union yield analysis, roundness analysis, assay analysis, stability study, and carries on the dissolution test

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31

Chiou, Jiun-Da, and 邱俊達. "Solubility Improvement for Development of Controlled Release Dosage Form with Minimization of Food Effect." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/42279539572203885417.

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碩士<br>臺北醫學大學<br>藥學研究所<br>95<br>Traditional immediate-release oral solid dosage forms of poorly soluble drugs have to be administered three times a day, which results in a significant fluctuation in the plasma drug concentration and drug toxic side effects. Therefore, development of controlled-release dosage forms is desirable for side effect reduction and for patient compliance. However, the poor aqueous solubility and dissolution rate lead to several problems such as low and unpredictable (or variable) physiological availability and therapeutic response, lack of dose proportionality, excessiv

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32

Rao, Shin-Yih, and 饒欣宜. "Skin-whitening Efficacy and Dosage Form Effect of Modified Seven-White Chinese Herbal Formulation." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/81042117148503726886.

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碩士<br>大仁科技大學<br>生物科技研究所<br>101<br>The objective of this study was to identify efficient skin-whitening formulation and dosage forms by using the traditional seven-white Chinese herbal formulation as the starting basis, then add or remove individual ingredients by screening their antioxidant and tyrosinase inhibitory activity. On top of that, oligopeptides and extract of natural plant, quercetin, were also included in the formulation for preventing and repairing possible photodamages associated with skin whitening. A secondary objective of this study was to establish a feasible platform for tes

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33

Hsiao, Fang-Hsiung, and 蕭芳雄. "Design of Controlled Release Dosage Form and In Vivo-In Vitro Correlations Study for Theophylline." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/36125609464682063888.

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碩士<br>元智大學<br>化學工程學系<br>91<br>In this study, theophylline was used as a model drug to illustrate how the relative rates of in vitro dissolution/ in vivo absorption may be affected by the HPMC concentration in the matrix tablets. The various HPMC concentrations used in the matrix tablets were 5%, 15% and 30%; a wet granulation method was utilized to fabricate the matrix tablets. The lower HPMC concentration formulation had faster release rate. The results showed that the in vitro dissolution rates of various formulations were a function of HPMC concentration. Both f1 and f2 values indicated the

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34

Fabian, June. "Preformulation and formulation study of dexchlorphenniramine maleate for use in the development of a new sustained release dosage form." Thesis, 1994. https://hdl.handle.net/10539/25978.

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A Dissertation Submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg, in Partial Fulfilment of the Requirements for the Degree of Master of Pharmacy Johannesburg, March 1994<br>Preformulation and formulation study of dexchlor- pheniramine maleate (DCPM) for it's inclusion into a gelforming sustained release dosage form was investigated. A modification of the USP apparatus 2 is proposed as an alternative to currently recommended USP dissolution apparatus for floating, gelforming drug delivery systems. In addition, the role of magnesium stearate and talc as dissolu

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35

Alli, Dhananjaya. "Interactions between non-ionic cellulose ethers and anionic surfactants and their influence on drug release from a solid unit dosage form /." 1990. http://www.gbv.de/dms/bs/toc/128384387.pdf.

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36

Van, der Watt Abel Hermanus. "Development and evaluation of a solid oral dosage form for an artesunate and mefloquine drug combination / Abel Hermanus van der Watt." Thesis, 2014. http://hdl.handle.net/10394/10809.

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Malaria affects about forty percent of the world’s population. Annually more than 1.5 million fatalities due to malaria occur and parasite resistance to existing antimalarial drugs such as mefloquine has already reached disturbingly high levels in South-East Asia and on the African continent. Consequently, there is a dire need for new drugs or formulations in the prophylaxis and treatment of malaria. Artesunate, an artemisinin derivative, represents a new category of antimalarials that is effective against drug-resistant Plasmodium falciparum strains and is of significance in the current antim

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