Log in

Relevant bibliographies by topics / Modulation des primes d'assurance / Journal articles

To see the other types of publications on this topic, follow the link: Modulation des primes d'assurance.

Journal articles on the topic 'Modulation des primes d'assurance'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Modulation des primes d'assurance.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Mwau, Cynthia Mwende, Patrick Weke, Bundi Ntwiga, and Joseph Makoteku Ottieno. "Phase Type Zero Truncated Poisson Lindley Distributions and their application in modeling Secondary Cancer Cases." Afrika Statistika 17, no. 1 (2022): 3145–64. http://dx.doi.org/10.16929/as/2022.3145.199.

Full text

Abstract:

L'assurance des maladies chroniques dont le cancer gagne du terrain au Kenya peu à peu. Ce pendant le traitement de ces maladies, pouvant entrainer des changements d'organes humains, tend à coûter plus cher, et en conséquence, à augmenter les primes d'assurance notablement. La modélisation de ces primes ne peut plus se faire avec des distributions ordinaires. Les méthodes utilisant des distributons zero-tronquées sont utilisées en particulier. Dans ce papier, elles sont utilisées en rapport avec des distributions Pareto, Weibul etc. Nous procédons à une comparaison de ces distributions et en p

APA, Harvard, Vancouver, ISO, and other styles

2

Legal, Renaud. "L'influence de l'offre de soins et du niveau des primes sur la demande d'assurance complémentaire santé en France." Revue économique 60, no. 2 (2009): 441. http://dx.doi.org/10.3917/reco.602.0441.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Okano, Kana, Jonathan Grainger, and Phillip J. Holcomb. "Rapid modulation of spoken word recognition by visual primes." Journal of Neurolinguistics 37 (February 2016): 58–67. http://dx.doi.org/10.1016/j.jneuroling.2015.09.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Kellenbach, Marion L., and Patricia T. Michie. "Modulation of Event-Related Potentials by Semantic Priming: Effects of Color-Cued Selective Attention." Journal of Cognitive Neuroscience 8, no. 2 (1996): 155–73. http://dx.doi.org/10.1162/jocn.1996.8.2.155.

Full text

Abstract:

The processing nature of N400, an event-related brain potential (ERP) component associated with semantic processing, was investigated in a paradigm combining a semantic priming lexical decision task and color-cued selective attention. Semantic priming effects on ERPs and reaction time (RT) were examined when targets and preceding semantically related primes were either both attended or both unattended, and when only either the prime or target was the focus of attention. Priming effects were determined by comparing semantically primed target ERPs (and RTs when appropriate) to their prime (in th

APA, Harvard, Vancouver, ISO, and other styles

5

Benthien, Fenja Mareike, and Guido Hesselmann. "Does Location Uncertainty Modulate Unconscious Processing Under Continuous Flash Suppression?" Advances in Cognitive Psychology 17, no. 1 (2021): 3–14. http://dx.doi.org/10.5709/acp-0312-3.

Full text

Abstract:

Previous research suggests that selective spatial attention is a determining factor for unconscious processing under continuous flash suppression (CFS), and specifically, that inattention toward stimulus location facilitates its unconscious processing by reducing the depth of CFS (Eo et al., 2016). The aim of our study was to further examine this modulation-by-attention model of CFS using a number priming paradigm. Participants (N = 26) performed a number comparison task on a visible target number (“compare target to five”). Prime-target pairs were either congruent (both smaller or larger than

APA, Harvard, Vancouver, ISO, and other styles

6

Boukarras, Sarah, Vanessa Era, Salvatore Maria Aglioti, and Matteo Candidi. "Modulation of preference for abstract stimuli following competence-based social status primes." Experimental Brain Research 238, no. 1 (2019): 193–204. http://dx.doi.org/10.1007/s00221-019-05702-z.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Wu, Yan, Mengyuan Zhang, Chi Zhang, and Xuehong Tian. "Fairness-related behaviour modulation by friendship is moderated by American primes in Chinese participants." Asian Journal of Social Psychology 18, no. 4 (2015): 299–310. http://dx.doi.org/10.1111/ajsp.12111.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Lavigne, Frédéric, Laurent Dumercy, and Nelly Darmon. "Determinants of Multiple Semantic Priming: A Meta-analysis and Spike Frequency Adaptive Model of a Cortical Network." Journal of Cognitive Neuroscience 23, no. 6 (2011): 1447–74. http://dx.doi.org/10.1162/jocn.2010.21504.

Full text

Abstract:

Recall and language comprehension while processing sequences of words involves multiple semantic priming between several related and/or unrelated words. Accounting for multiple and interacting priming effects in terms of underlying neuronal structure and dynamics is a challenge for current models of semantic priming. Further elaboration of current models requires a quantifiable and reliable account of the simplest case of multiple priming resulting from two primes on a target. The meta-analytic approach offers a better understanding of the experimental data from studies on multiple priming reg

APA, Harvard, Vancouver, ISO, and other styles

9

Godard, Marc, Yannick Wamain, and Solène Kalénine. "Do manufactured and natural objects evoke similar motor information? The case of action priming." Quarterly Journal of Experimental Psychology 72, no. 12 (2019): 2801–6. http://dx.doi.org/10.1177/1747021819862210.

Full text

Abstract:

There is considerable evidence that visually presented manipulable objects evoke motor information, supporting the existence of affordance effects during object perception. However, most arguments come from stimulus–response compatibility paradigms, raising the issue of the automaticity of affordance effects. Action priming paradigms overcome this issue but show less reliable results, possibly because affordance effects are moderated by additional factors. The present study aimed to assess whether affordance effects highlighted in action priming paradigms could be affected by object category (

APA, Harvard, Vancouver, ISO, and other styles

10

Watkins, Kate, and Tomáš Paus. "Modulation of Motor Excitability during Speech Perception: The Role of Broca's Area." Journal of Cognitive Neuroscience 16, no. 6 (2004): 978–87. http://dx.doi.org/10.1162/0898929041502616.

Full text

Abstract:

Studies in both human and nonhuman primates indicate that motor and premotor cortical regions participate in auditory and visual perception of actions. Previous studies, using transcranial magnetic stimulation (TMS), showed that perceiving visual and auditory speech increased the excitability of the orofacial motor system during speech perception. Such studies, however, cannot tell us which brain regions mediate this effect. In this study, we used the technique of combining positron emission tomography with TMS to identify the brain regions that modulate the excitability of the motor system du

APA, Harvard, Vancouver, ISO, and other styles

11

Miozzi, Laura, Anna Maria Vaira, Federico Brilli, et al. "Arbuscular Mycorrhizal Symbiosis Primes Tolerance to Cucumber Mosaic Virus in Tomato." Viruses 12, no. 6 (2020): 675. http://dx.doi.org/10.3390/v12060675.

Full text

Abstract:

Tomato plants can establish symbiotic interactions with arbuscular mycorrhizal fungi (AMF) able to promote plant nutrition and prime systemic plant defenses against pathogens attack; the mechanism involved is known as mycorrhiza-induced resistance (MIR). However, studies on the effect of AMF on viral infection, still limited and not conclusive, indicate that AMF colonization may have a detrimental effect on plant defenses against viruses, so that the term “mycorrhiza-induced susceptibility” (MIS) has been proposed for these cases. To expand the case studies to a not yet tested viral family, th

APA, Harvard, Vancouver, ISO, and other styles

12

Roberts, James W., Simon J. Bennett, and Spencer J. Hayes. "Impression or expression? The influence of self-monitoring on the social modulation of motor contagion." Quarterly Journal of Experimental Psychology 71, no. 4 (2018): 850–58. http://dx.doi.org/10.1080/17470218.2017.1307430.

Full text

Abstract:

Social primes (pro-social, anti-social) can modulate mimicry behaviour. To date, these social modulation effects have been explained by the primed incentive to affiliate with another (Social Top-Down Response Modulation; STORM) and the primed active-self-concept leading to behaviour that is either consistent or inconsistent with the primed-construct (Active-Self account). This study was designed to explore the explanatory power of each of these accounts and thereby gain a greater understanding of how social modulation unfolds. To do this, we assessed social modulation of motor contagion in ind

APA, Harvard, Vancouver, ISO, and other styles

13

Fu, Yong, Yan Ding, Taoli Zhou, Xiaolan Fu, and Wenyue Xu. "Plasmodium yoelii blood-stage primes macrophage-mediated innate immune response through modulation of toll-like receptor signalling." Malaria Journal 11, no. 1 (2012): 104. http://dx.doi.org/10.1186/1475-2875-11-104.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Aizawa, Kei, Lawrence A. Turner, Dorothee Weihrauch, Zeljko J. Bosnjak та Wai-Meng Kwok. "Protein Kinase C-ε Primes the Cardiac Sarcolemmal Adenosine Triphosphate–sensitive Potassium Channel to Modulation by Isoflurane". Anesthesiology 101, № 2 (2004): 381–89. http://dx.doi.org/10.1097/00000542-200408000-00019.

Full text

Abstract:

Background Cardioprotection by volatile anesthetic-induced preconditioning is known to involve intracellular signaling pathways. Recent studies have shown that protein kinase C (PKC) plays an important role in anesthetic-induced preconditioning. In this study, the effects of the activation of specific isozymes of PKC, specifically PKC-epsilon and -delta, on the modulation of the sarcolemmal adenosine triphosphate-sensitive potassium (sarcKATP) channel by isoflurane were investigated. Methods The sarcKATP current was measured in ventricular myocytes isolated from guinea pig hearts using the who

APA, Harvard, Vancouver, ISO, and other styles

15

Chang, Ruohan, Xiaoting Wang, and Jinfeng Ding. "Semantic Activation in Badminton Action Processing and Its Modulation by Action Duration: An ERP Study." Brain Sciences 12, no. 11 (2022): 1458. http://dx.doi.org/10.3390/brainsci12111458.

Full text

Abstract:

Action processing is crucial for sports activities. Using event-related potentials (ERPs), the present study investigated whether semantics were activated in action processing and, if so, whether semantic activation was modulated by action duration. Badminton athletes were recruited to finish a lexical decision task following an action-semantic priming paradigm, in which short (400 ms) or long (1000 ms) action videos served as primes, and semantically congruent or incongruent action words served as targets. The ERP results showed a P300 effect, that is, larger P300 amplitudes were observed for

APA, Harvard, Vancouver, ISO, and other styles

16

Diaz-Garrido, Natalia, Josefa Badia, and Laura Baldomà. "Modulation of Dendritic Cells by Microbiota Extracellular Vesicles Influences the Cytokine Profile and Exosome Cargo." Nutrients 14, no. 2 (2022): 344. http://dx.doi.org/10.3390/nu14020344.

Full text

Abstract:

Gut bacteria release extracellular vesicles (BEVs) as an intercellular communication mechanism that primes the host innate immune system. BEVs from E. coli activate dendritic cells (DCs) and subsequent T-cell responses in a strain-specific manner. The specific immunomodulatory effects were, in part, mediated by differential regulation of miRNAs. This study aimed to deepen understanding of the mechanisms of BEVs to drive specific immune responses by analyzing their impact on DC-secreted cytokines and exosomes. DCs were challenged with BEVs from probiotic and commensal E. coli strains. The abili

APA, Harvard, Vancouver, ISO, and other styles

17

Maldonado, Maricela, Rebeccah J. Luu, Michael E. P. Ramos, and Jin Nam. "ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation." Stem Cell Research 17, no. 2 (2016): 222–27. http://dx.doi.org/10.1016/j.scr.2016.07.009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Borrero Garcia, Luis, Oliver Reiners, Alba Gonzalez-Junca, Hideho Okada та Mary Helen Barcellos-Hoff. "RDNA-09. RADIATION PRIMES SB28 GLIOBLASTOMA FOR RESPONSE TO TGFβ AND PD-L1 NEUTRALIZING ANTIBODIES". Neuro-Oncology 21, Supplement_6 (2019): vi208. http://dx.doi.org/10.1093/neuonc/noz175.868.

Full text

Abstract:

Abstract SB28 is a new luciferase expressing murine glioblastoma (GBM) cell line whose morphology, growth pattern, mutational burden immune infiltrate more closely resembles human GBM and is unresponsive to immunotherapy (OncoImmunology, 7:12, e1501137). Radiation therapy (RT) has the potential to improve response to combinations by multiple means: cell kill that may activate an immune response, effects on vascular system may improve drug access, induction of DNA damage that can be augmented by targeted or chemotherapy, and modulation of the tumor microenvironment. High transforming growth fac

APA, Harvard, Vancouver, ISO, and other styles

19

Savotchenko, Alina, Arthur Romanov, Dmytro Isaev, et al. "Neuraminidase Inhibition Primes Short-Term Depression and Suppresses Long-Term Potentiation of Synaptic Transmission in the Rat Hippocampus." Neural Plasticity 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/908190.

Full text

Abstract:

Neuraminidase (NEU) is a key enzyme that cleaves negatively charged sialic acid residues from membrane proteins and lipids. Clinical and basic science studies have shown that an imbalance in NEU metabolism or changes in NEU activity due to various pathological conditions parallel with behavior and cognitive impairment. It has been suggested that the decreases of NEU activity could cause serious neurological consequences. However, there is a lack of direct evidences that modulation of endogenous NEU activity can impair neuronal function. Using combined rat entorhinal cortex/hippocampal slices a

APA, Harvard, Vancouver, ISO, and other styles

20

Platta, Harald W., Mykhaylo O. Debelyy, Fouzi El Magraoui, and Ralf Erdmann. "The AAA peroxins Pex1p and Pex6p function as dislocases for the ubiquitinated peroxisomal import receptor Pex5p." Biochemical Society Transactions 36, no. 1 (2008): 99–104. http://dx.doi.org/10.1042/bst0360099.

Full text

Abstract:

The discovery of the peroxisomal ATPase Pex1p triggered the beginning of the research on AAA (ATPase associated with various cellular activities) proteins and the genetic dissection of peroxisome biogenesis. Peroxisomes are virtually ubiquitous organelles, which are connected to diverse cellular functions. The highly diverse and adaptive character of peroxisomes is accomplished by modulation of their enzyme content, which is mediated by dynamically operating protein-import machineries. The import of matrix proteins into the peroxisomal lumen has been described as the ATP-consuming step, but th

APA, Harvard, Vancouver, ISO, and other styles

21

Manske, Jill, Lucas Brand, Amanda Kastelic, and Angelene Westin. "Substance P modulation of anti-tumor responses: enhanced tumor resistance by adoptive transfer of SP-treated T cells and increased NK cell activity (50.5)." Journal of Immunology 178, no. 1_Supplement (2007): S91. http://dx.doi.org/10.4049/jimmunol.178.supp.50.5.

Full text

Abstract:

Abstract Substance P (SP) is a neuropeptide that has been shown to have immunoregulatory properties including effects on mediators involved in anti-tumor immunity. In previous studies we have shown that treatment of mice with SP provides protection against tumor growth. This protection requires both T cells and NK cells, and adoptive transfer of cells from SP-treated animals can transfer tumor protection. These studies suggest a model in which SP treatment prior to tumor challenge primes immune mediators to prevent or delay tumor establishment. In this study we examined the role of NK cells an

APA, Harvard, Vancouver, ISO, and other styles

22

Wu, Chenggang, Juan Zhang, and Zhen Yuan. "Exploring Affective Priming Effect of Emotion-Label Words and Emotion-Laden Words: An Event-Related Potential Study." Brain Sciences 11, no. 5 (2021): 553. http://dx.doi.org/10.3390/brainsci11050553.

Full text

Abstract:

In order to explore the affective priming effect of emotion-label words and emotion-laden words, the current study used unmasked (Experiment 1) and masked (Experiment 2) priming paradigm by including emotion-label words (e.g., sadness, anger) and emotion-laden words (e.g., death, gift) as primes and examined how the two kinds of words acted upon the processing of the target words (all emotion-laden words). Participants were instructed to decide the valence of target words, and their electroencephalogram was recorded at the same time. The behavioral and event-related potential (ERP) results sho

APA, Harvard, Vancouver, ISO, and other styles

23

Alfayez, Eman, Lorenzo Veschini, Monica Dettin, et al. "DAR 16-II Primes Endothelial Cells for Angiogenesis Improving Bone Ingrowth in 3D-Printed BCP Scaffolds and Regeneration of Critically Sized Bone Defects." Biomolecules 12, no. 11 (2022): 1619. http://dx.doi.org/10.3390/biom12111619.

Full text

Abstract:

Bone is a highly vascularized tissue and relies on the angiogenesis and response of cells in the immediate environmental niche at the defect site for regeneration. Hence, the ability to control angiogenesis and cellular responses during osteogenesis has important implications in tissue-engineered strategies. Self-assembling ionic-complementary peptides have received much interest as they mimic the natural extracellular matrix. Three-dimensional (3D)-printed biphasic calcium phosphate (BCP) scaffolds coated with self-assembling DAR 16-II peptide provide a support template with the ability to re

APA, Harvard, Vancouver, ISO, and other styles

24

Iqbal, Jameel, та Mone Zaidi. "CD38 is required for priming by TNF-α: a mechanism for extracellular coordination of cell fate". American Journal of Physiology-Renal Physiology 292, № 4 (2007): F1283—F1290. http://dx.doi.org/10.1152/ajprenal.00381.2006.

Full text

Abstract:

Cytokines are protein messengers that act to modulate the differentiation or activation of their target cells. Bone marrow macrophages can become activated tissue macrophages, dendritic cells, or osteoclasts depending on to which cytokines they are exposed. However, one cytokine can often induce divergent outcomes, suggesting that other signals are needed to establish the specificity of the result. We hypothesize that these signals may derive from the local environment and serve to prime cells to respond toward a specific outcome. Here, it is shown that the cytokine TNF-α is capable of affecti

APA, Harvard, Vancouver, ISO, and other styles

25

Krisna Dewi, Desak Ayu, I. Nengah Sudipa, and Ni Wayan Sukarini. "THE TRANSLATION OF STATE VERBS IN GONE WITH THE WIND INTO LALU BERSAMA ANGIN : NATURAL SEMANTIC METALANGUAGE APPROACH." KULTURISTIK: Jurnal Bahasa dan Budaya 3, no. 1 (2019): 54. http://dx.doi.org/10.22225/kulturistik.3.1.940.

Full text

Abstract:

This writing aims to reveal what translation techniques are applied in translating state verbs and. to analyze how meanings are retained from source language text to target language text in the novel. It is also highlights the correlation between translation and semantic primes studies. The data focuses on the translation of state verbs taken from the novel Gone with the Wind into Lalu Bersama Angin written by Margareth Mitchell by applying the Natural Semantic Metalanguage approach. This study used a qualitative method means the data are collected by observation and note taking process. There

APA, Harvard, Vancouver, ISO, and other styles

26

Berger, Alexander, Simon Sanwald, Christian Montag, and Markus Kiefer. "The Influence of the BDNF Val66Met Polymorphism on Mechanisms of Semantic Priming: Analyses with Drift-Diffusion Models of Masked and Unmasked Priming." Advances in Cognitive Psychology 17, no. 1 (2021): 70–87. http://dx.doi.org/10.5709/acp-0318-z.

Full text

Abstract:

Automatic and strategic processes in semantic priming can be investigated with masked and unmasked priming tasks. Unmasked priming is thought to enable strategic processes due to the conscious processing of primes, while masked priming exclusively depends on automatic processes due to the invisibility of the prime. Besides task properties, interindividual differences may alter priming effects. In a recent study, masked and unmasked priming based on mean response time (RT) and error rate (ER) differed as a function of the BDNF Val66Met polymorphism (Sanwald et al., 2020). The BDNF Val66Met poly

APA, Harvard, Vancouver, ISO, and other styles

27

Ong, C. P. "A Scientific Perspective of the Three Harmony Principle of Taijiquan." Journal of Integrative Medicine 11, no. 1 (2022): 12. http://dx.doi.org/10.30564/jim.v11i1.4654.

Full text

Abstract:

The Three Harmony Principle helps to regulate whole-body motion in harmony by balancing and aligning the movements of the body segments. Taijiquan uses the fangsong-relaxtion modality to resolve the switching back and forth of the active muscle forces and the passive tensional forces of tendons, ligaments and fascial tissues. Fangsong induces the modulation of the muscles to resettle in a better state of balance, thus is necessarily a manipulation of the fascial tissues enveloping the muscles, organs and structures. In so doing, fangsong-relaxation cultivates the cognition and sensation of the

APA, Harvard, Vancouver, ISO, and other styles

28

Gentsch, Antje, and Simone Schütz-Bosbach. "I Did It: Unconscious Expectation of Sensory Consequences Modulates the Experience of Self-agency and Its Functional Signature." Journal of Cognitive Neuroscience 23, no. 12 (2011): 3817–28. http://dx.doi.org/10.1162/jocn_a_00012.

Full text

Abstract:

The ability to recognize oneself in voluntary action is called the sense of agency and refers to the experience of causing one's own actions and their sensory consequences. This form of self-awareness is important not only for motor control but also for social interactions and the ascription of causal responsibility. Here, we examined the sense of agency at early and prereflective stages of action perception using ERPs. Subjects performed a visual forced-choice response task in which action effects were either caused by the subject or by the computer. In addition, to modulate the conscious exp

APA, Harvard, Vancouver, ISO, and other styles

29

Piorczynski, Ted B., Saagar Jain, Manuel Pazos, Yun Kyoung Tiger, Seda S. Tolu, and Jennifer E. Amengual. "Dual HDAC and EZH2 Inhibition Primes Mosunetuzumab for the Treatment of Germinal Center-Derived B-Cell Lymphoma." Blood 144, Supplement 1 (2024): 973. https://doi.org/10.1182/blood-2024-194360.

Full text

Abstract:

Chromatin-modifying genes, such as CREBBP and EZH2, are ubiquitously mutated in germinal center-derived B-cell (GCB) lymphomas, leading to impaired antigen presentation, immune escape, and malignancy progression. Belinostat (BEL), an HDAC inhibitor, and tazemetostat (TAZ), an EZH2 inhibitor, counteract the epigenetic derangements caused by CREBBP and EZH2 mutations. Mosunetuzumab (MOSUN) is an anti-CD20/CD3 bispecific antibody that relies on stimulated T cells and B:T-cell interaction for its activity. Though MOSUN exhibits an impressive overall response rate in follicular lymphoma, the progre

APA, Harvard, Vancouver, ISO, and other styles

30

Low, Justin, Vidya Chandramohan, Michelle Bowie, et al. "BSCI-20 STING EPIGENETIC SILENCING IN GLIOMAS CAN BE RESCUED BY METHYLTRANSFERASE INHIBITION: IMPLICATIONS FOR NOVEL THERAPEUTIC APPROACHES." Neuro-Oncology Advances 4, Supplement_1 (2022): i5. http://dx.doi.org/10.1093/noajnl/vdac078.018.

Full text

Abstract:

Abstract The stimulator of interferon genes (STING) is a key component of the innate immune response to pathogenic cytosolic DNA, resulting in IRF3- and NFκB-dependent transcription of type I interferons (IFN) and pro-inflammatory cytokines. STING activation primes endogenous antitumor immunity and is disrupted in a variety of cancers. Here we investigate STING signalling in glioblastoma (GBM) patient samples. STING agonist treatment of ex vivo gliomas leads to inconsistent induction of type I IFN responses that are restricted to tumor associated myeloid cells. Indeed, single-cell transcriptom

APA, Harvard, Vancouver, ISO, and other styles

31

Carbone, Carmine, Geny Piro, Antonio Agostini, et al. "Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer." Journal for ImmunoTherapy of Cancer 9, no. 9 (2021): e002876. http://dx.doi.org/10.1136/jitc-2021-002876.

Full text

Abstract:

BackgroundComplex tumor and immune microenvironment render pancreatic ductal adenocarcinoma (PDAC) resistant to immune checkpoint inhibitors (ICIs). Therefore, a strategy to convert the immune hostile into an immunopermissive tumor is required. Recent studies showed that intratumoral injection of Toll-like receptor 9 agonist IMO-2125 primes the adaptive immune response. Phase I and II trials with intratumoral IMO-2125 demonstrated its safety and antitumoral activity.MethodsWe generated an array of preclinical models by orthotopically engrafting PDAC-derived cell lines in syngeneic mice and cat

APA, Harvard, Vancouver, ISO, and other styles

32

Espinosa-Garcia, Claudia, Fahim Atif, Seema Yousuf, Iqbal Sayeed, Gretchen N. Neigh, and Donald G. Stein. "Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury." International Journal of Molecular Sciences 21, no. 11 (2020): 3740. http://dx.doi.org/10.3390/ijms21113740.

Full text

Abstract:

NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome inhibition and autophagy induction attenuate inflammation and improve outcome in rodent models of cerebral ischemia. However, the impact of chronic stress on NLRP3 inflammasome and autophagic response to ischemia remains unknown. Progesterone (PROG), a neuroprotective steroid, shows promise in reducing excessive inflammation associated with poor outcome in ischemic brain injury patients with comorbid conditions, including elevated stress. Stress primes microglia, mainly by the release of alarmins such as high-mobility group box-1

APA, Harvard, Vancouver, ISO, and other styles

33

McColl, S. R., E. Krump, P. H. Naccache, et al. "Granulocyte-macrophage colony-stimulating factor increases the synthesis of leukotriene B4 by human neutrophils in response to platelet-activating factor. Enhancement of both arachidonic acid availability and 5-lipoxygenase activation." Journal of Immunology 146, no. 4 (1991): 1204–11. http://dx.doi.org/10.4049/jimmunol.146.4.1204.

Full text

Abstract:

Abstract Granulocyte-macrophage CSF (GM-CSF) primes human neutrophils for increased functional responsiveness to a variety of inflammatory agonists. In the present report, we have investigated the effect of human GM-CSF on the ability of platelet-activating factor (PAF) to induce the synthesis of 5-lipoxygenase products in human neutrophils. Human neutrophils stimulated with PAF in the range of 10(-5) to 10(-7) M for 15 min released small quantities of leukotriene B4 and its omega-oxidation products, 20-OH- and 20-COOH-leukotriene B4 in amounts that were detectable by enzyme immunoassay. Prein

APA, Harvard, Vancouver, ISO, and other styles

34

Reiner, N. E., W. Ng, C. B. Wilson, W. R. McMaster, and S. K. Burchett. "Modulation of in vitro monocyte cytokine responses to Leishmania donovani. Interferon-gamma prevents parasite-induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1." Journal of Clinical Investigation 85, no. 6 (1990): 1914–24. http://dx.doi.org/10.1172/jci114654.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Kim, Chihwa, Wu Wan, Rui Liu, Magdalena Kucia, Janina Ratajczak, and Mariusz Z. Ratajczak. "An Unexpected Role for the Complement C5b-C9 Membrane Attack Complex (MAC) In Trafficking of Hematopoietic Stem/Progenitor Cells - a Novel Unexpected Link Between Innate Immunity and Hematopoiesis." Blood 116, no. 21 (2010): 555. http://dx.doi.org/10.1182/blood.v116.21.555.555.

Full text

Abstract:

Abstract Abstract 555 We previously reported that complement cascade (CC) is activated in bone marrow (BM) during mobilization of hematopoietic stem/progenitor cells (HSPCs; Blood 2003;101:3784; Blood 2004;103:2071; and Blood 2005;105:40) and that C5 cleavage fragments direct egress of HSPCs from BM into peripheral blood (PB) (Leukemia 2009;23:2052 and Leukemia 2010;24:976). Accordingly, C5 cleavage fragments (C5a and desArgC5a) stimulate myeloid cells in BM to secrete proteolytic enzymes and chemoattract granulocytes into peripheral blood (PB). Therefore, granulocytes form a first wave of cel

APA, Harvard, Vancouver, ISO, and other styles

36

Li, Baorong, Yingmiao Liu, Cong Zhang, et al. "Neutrophil Extracellular Traps Enhance Procoagulant Activity in Patients with Oral Squamous Cell Carcinoma." Blood 132, Supplement 1 (2018): 2399. http://dx.doi.org/10.1182/blood-2018-99-115737.

Full text

Abstract:

Abstract Background: Cancer patients are considered to be prothrombotic with major disturbances in hemostasis that are associated with an increased risk of venous thromboembolism, especially in patients with advanced cancer. Recently reports show that the high levels of circulating microparticles (MPs) have procoagulant activity (PCA) in oral squamous cell carcinoma (OSCC). However, this study did not address the question of what specific mechanism might underlie the PCA in OSCC. Neutrophil extracellular traps (NETs) are activated neutrophil-derived web-like structures, which have emerged as i

APA, Harvard, Vancouver, ISO, and other styles

37

Fernandez, Matthew Emilio, Yasir Alshehry, Laura Graham, et al. "Abstract 6521: Macrophage-targeting immunotherapy enhances chemotherapy response in primary and metastatic triple-negative breast cancer models." Cancer Research 84, no. 6_Supplement (2024): 6521. http://dx.doi.org/10.1158/1538-7445.am2024-6521.

Full text

Abstract:

Abstract Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks targeted treatment options. While immune checkpoint blockade leads to significant benefits in the treatment of TNBC when in combination with chemotherapy, recurrence, metastasis, and chemoresistance still remain major challenges. The purpose of this study was to assess the ability of a colony-stimulating factor 1 receptor inhibitor (CSF-1Ri) to shift the phenotype of the tumor microenvironment (TME) in murine models of TNBC, and the potential benefit of such in enhancing standard of care chemo

APA, Harvard, Vancouver, ISO, and other styles

38

"Hausse des primes d'assurance-maladie: seuil de tolérance atteint!" Schweizerische Ärztezeitung 86, no. 41 (2005): 2309. http://dx.doi.org/10.4414/saez.2005.11510.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

"Hausse des primes d'assurance-maladie: seuil de tolérance atteint!" Bulletin des Médecins Suisses 86, no. 41 (2005): 2309. http://dx.doi.org/10.4414/bms.2005.11510.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

"Assurance groupe — Réduction des primes payables par la compagnie et les employés à la suite de l'adoption de la loi de l'assurance hospitalisation du Québec." Jurisprudence du travail 17, no. 3 (2014): 333–34. http://dx.doi.org/10.7202/1021579ar.

Full text

Abstract:

Sommaire Sans pour cela que soient en rien diminués ou modifiés les bénéfices et avantages énumérés au plan d'assurance-groupe inclus dans la convention collective liant les parties, la Compagnie a le droit de diminuer sa contribution à ce plan, lorsque, par l'adoption de la Loi de l'assurance hospitalisation, l'Etat a assumé une partie des frais hospitaliers prévus par la convention collective existante. Hafner Fabrics of Canada Ltd., Granby, vs l'Union des Employés de Hafner Fabrics de Granby, Que.; M. le Juge André Montpetit, président; Me Jean-H. Gagné, C.R., arbitre patronal; Me Jean Marq

APA, Harvard, Vancouver, ISO, and other styles

41

ACHIBANE, MUSTAPHA, and BTISSAM TAHRAOUI. "La mesure du risque opérationnel : Essai de modélisation pour le cas d'une compagnie Marocaine d'assurance." March 29, 2020. https://doi.org/10.5281/zenodo.3732761.

Full text

Abstract:

La norme européenne Solvabilité II est  entrée  en 2016 au Maroc et  elle a remplacé la  Solvabilité I. Elle oblige les compagnies d’assurance d’adopter un nouveau cadre réglementaire plus strict mais il peut  prendre en considération d’autres risques. Une des grandes nouveautés est que les compagnies ont l’obligation de mobiliser une partie de leurs fonds propres en couverture de leur exposition aux risques opérationnels. Pour calculer ce montant de capital, le régulateur pro

APA, Harvard, Vancouver, ISO, and other styles

42

Miozzi, Laura, Anna Maria Vaira, Federico Brilli, et al. "Arbuscular Mycorrhizal Symbiosis Primes Tolerance to Cucumber Mosaic Virus in Tomato." June 22, 2020. https://doi.org/10.5281/zenodo.5512646.

Full text

Abstract:

Tomato plants can establish symbiotic interactions with arbuscular mycorrhizal fungi (AMF) able to promote plant nutrition and prime systemic plant defenses against pathogens attack; the mechanism involved is known as mycorrhiza-induced resistance (MIR). However, studies on the eect of AMF on viral infection, still limited and not conclusive, indicate that AMF colonization may have a detrimental eect on plant defenses against viruses, so that the term “mycorrhiza-induced susceptibility” (MIS) has been proposed for these cases. To expand the case studies to a not yet tested viral fa

APA, Harvard, Vancouver, ISO, and other styles

43

Cypryk, Wojciech, Liliana Czernek, Katarzyna Horodecka, et al. "Lipopolysaccharide Primes Human Macrophages for Noncanonical Inflammasome-Induced Extracellular Vesicle Secretion." Journal of Immunology, December 14, 2022. http://dx.doi.org/10.4049/jimmunol.2200444.

Full text

Abstract:

Abstract Human macrophages secrete extracellular vesicles (EVs) loaded with numerous immunoregulatory proteins. Vesicle-mediated protein secretion in macrophages is regulated by poorly characterized mechanisms; however, it is now known that inflammatory conditions significantly alter both the quantities and protein composition of secreted vesicles. In this study, we employed high-throughput quantitative proteomics to characterize the modulation of EV-mediated protein secretion during noncanonical caspase-4/5 inflammasome activation via LPS transfection. We show that human macrophages activate

APA, Harvard, Vancouver, ISO, and other styles

44

Peters, James F., and Tharaka Liyanage. "Energy Dissipation in Hilbert Envelopes on Motion Waveforms Detected in Sequences of Video Frames." Communications in Advanced Mathematical Sciences, November 16, 2024. http://dx.doi.org/10.33434/cams.1549815.

Full text

Abstract:

This paper introduces the use of the Hilbert envelope on oscillatory motion waveforms in detecting energy dissipation by various vibrating systems. A Hilbert envelope is a curve tangent to peak points on a motion waveform. The basic approach is to compare non-modulated vs. modulated waveforms in measuring energy loss during the vibratory motion $m(t)$ at time $t$ of moving object such as a walker, runner or biker recorded in a video. Modulation of $m(t)$ is achieved by using Mersenne primes to adjust the frequency $\omega$ of the Euler exponential in \boxed{m(t)e^{\pm j2\pi \omega t}dt}. Exped

APA, Harvard, Vancouver, ISO, and other styles

45

Gillmeister, Helge, Ieva Šmate, Dimitra Savva, Haojie Li, Christina Parapadakis, and Julia Adler. "Confrontation with others' emotions changes bodily resonance differently in those with low and high levels of depersonalization." Philosophical Transactions of the Royal Society B: Biological Sciences 379, no. 1908 (2024). http://dx.doi.org/10.1098/rstb.2023.0248.

Full text

Abstract:

We present novel research on the cortical dynamics of atypical perceptual and emotional processing in people with symptoms of depersonalization–derealization disorder (DP-DR). We used electroencephalography (EEG)/event-related potentials (ERPs) to delineate the early perceptual mechanisms underlying emotional face recognition and mirror touch in adults with low and high levels of DP-DR symptoms (low-DP and high-DP groups). Face-sensitive visual N170 showed markedly less differentiation for emotional versus neutral face–voice stimuli in the high- than in the low-DP group. This effect was relate

APA, Harvard, Vancouver, ISO, and other styles

46

Lyu, Yuanyuan, Francesca Zidda, Stefan T. Radev, et al. "Gamma Band Oscillations Reflect Sensory and Affective Dimensions of Pain." Frontiers in Neurology 12 (January 10, 2022). http://dx.doi.org/10.3389/fneur.2021.695187.

Full text

Abstract:

Pain is a multidimensional process, which can be modulated by emotions; however, the mechanisms underlying this modulation are unknown. We used pictures with different emotional valence (negative, positive, and neutral) as primes and applied electrical painful stimuli as targets to healthy participants. We assessed pain intensity and unpleasantness ratings and recorded electroencephalograms (EEGs). We found that pain unpleasantness and not pain intensity ratings were modulated by emotion, with increased ratings for negative and decreased ratings for positive pictures. We also found two consecu

APA, Harvard, Vancouver, ISO, and other styles

47

Bedwell, Gillian J., Luyanduthando Mqadi, Peter Kamerman, Mark R. Hutchinson, Romy Parker, and Victoria J. Madden. "Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception." Pain, May 15, 2025. https://doi.org/10.1097/j.pain.0000000000003658.

Full text

Abstract:

Abstract Adversity in childhood elevates the risk of persistent pain in adulthood. Neuroimmune interactions are a candidate mechanistic link between childhood adversity and persistent pain. We aimed to clarify whether immune reactivity is associated with provoked differences in nociceptive processing in adults with a range of childhood adversity. Pain-free adults (n = 96; 61 female; median [range] age: 23 [18-65] years old) with a history of mild to severe childhood adversity underwent psychophysical assessments before and after in vivo neural provocation (high-frequency electrical stimulation

APA, Harvard, Vancouver, ISO, and other styles

48

Gupte, Tejas M., Michael Ritt, Matthew Dysthe, Rabia U. Malik, and Sivaraj Sivaramakrishnan. "Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling." Nature Communications 10, no. 1 (2019). http://dx.doi.org/10.1038/s41467-019-12755-9.

Full text

Abstract:

Abstract Despite the crowded nature of the cellular milieu, ligand–GPCR–G protein interactions are traditionally viewed as spatially and temporally isolated events. In contrast, recent reports suggest the spatial and temporal coupling of receptor–effector interactions, with the potential to diversify downstream responses. In this study, we combine protein engineering of GPCR–G protein interactions with affinity sequestration and photo-manipulation of the crucial Gα C terminus, to demonstrate the temporal coupling of cognate and non-cognate G protein interactions through priming of the GPCR con

APA, Harvard, Vancouver, ISO, and other styles

49

de Gaetano, Monica, Kawthar Alghamdi, Simone Marcone та Orina Belton. "Abstract 204: Conjugated Linoleic Acid Induces an Atheroprotective Macrophage MΦ2 Phenotype and Limits Foam Cell Formation". Arteriosclerosis, Thrombosis, and Vascular Biology 35, suppl_1 (2015). http://dx.doi.org/10.1161/atvb.35.suppl_1.204.

Full text

Abstract:

Background: Atherosclerosis, the underlying cause of heart attack and stroke, is a progresive dyslipidemic and inflammatory disease where monocyte-derived macrophage cells play a pivotal role. Although most of the mechanisms that contribute to the progression of atherosclerosis have been identified, there is limited information on those governing regression. Conjugated linoleic acid (CLA) is a group of isomers of linoleic acid that differ in the position and/or geometry of their double bonds. We have previously shown that a specific CLA blend (80:20 cis-9,trans-11:trans-10,cis-12-CLA) induces

APA, Harvard, Vancouver, ISO, and other styles

50

Chen, Yingying, Fengxiang Tan, Qing Fang та ін. "Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway". Advanced Science, 29 червня 2025. https://doi.org/10.1002/advs.202500895.

Full text

Abstract:

AbstractThe regulatory mechanisms governing cell fate determination, particularly lineage diversification during mammalian embryonic development, remain poorly understood with in‐depth regulatory paradigms yet to be fully elucidated. Here, leveraging the epigenetic landscape of mouse gastrula, p‐Enh is identified, an enhancer located within the first intron of Cdx2 and epigenetically pre‐marked in the primitive streak region, as a pivotal regulator for posterior tissue development in mouse embryos. Morphological and single‐cell transcriptomic analyses confirmed embryonic lethality phenotype wi

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!