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Relevant bibliographies by topics / Molecular beam mass spectrometry / Dissertations / Theses

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Dissertations / Theses on the topic 'Molecular beam mass spectrometry'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Secco, Andrea. "Use of the molecular beam mass spectrometry to study the low-temperature combustion chemistry." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14506/.

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With the aim to reduce the global pollution caused by the increasing levels of NOx, CO and CO2 emitted by internal combustion engines, the study of low-temperature chemistry (LTC) of the combustion process has been greatly enhanced. The goal of this thesis work is to evaluate the performances of the time-of-flight Molecular Beam Mass Spectrometry (TOF-MBMS) in the analysis of the oxidation of propane at low temperature with strong interest in the detection of fleeting species to verify the low-temperature oxidation mechanism. To do that we performed two different experiments: propane oxidatio

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2

Osaka, J., Senthil M. Kumar, H. Toyoda, T. Ishijima, H. Sugai, and T. Mizutani. "Role of atomic nitrogen during GaN growth by plasma-assisted molecular beam epitaxy revealed by appearance mass spectrometry." American Institute of Physics, 2007. http://hdl.handle.net/2237/8775.

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3

Tsang, Roland S. "Characterisation of the gas-phase environment in a hot filament diamond chemical vapour deposition chamber using molecular beam mass spectrometry." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389238.

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4

Leeds, Stuart M. "Characterisation of the gas-phase environment in a microwave plasma enhanced diamond chemical vapour deposition reactor using molecular beam mass spectrometry." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297978.

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5

Fox, Oliver James Louis. "Deposition of nanocrystalline diamond films by MW plasma CVD & gas-phase diagnostics using in-situ molecular-beam mass spectrometry and emission spectroscopy." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544422.

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6

Crichton, Edward. "Construction of a molecular beam mass spectrometer for in-situ probing of a diamond chemical vapour deposition environment." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443689.

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7

Ellerweg, Dirk [Verfasser], Achim von [Gutachter] Keudell, and Peter [Gutachter] Awakowicz. "Reaction chemistry in oxygen or hexamethyldisiloxane containing noble gas microplasma jets : a quantitative molecular beam mass spectrometry study / Dirk Ellerweg ; Gutachter: Achim von Keudell, Peter Awakowicz ; Fakultät für Physik und Astronomie." Bochum : Ruhr-Universität Bochum, 2012. http://d-nb.info/1209358409/34.

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8

Fischer, Andreas [Verfasser], Wolfram [Akademischer Betreuer] Sander, and Martina [Akademischer Betreuer] Havenith. "Development of a molecular beam mass spectrometer and a supersonic jet expansion pyrolyzer for the characterization of reactive organic intermediates / Andreas Fischer. Gutachter: Wolfram Sander ; Martina Havenith." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1089006306/34.

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9

Moreira, Ana Sofia Pereira. "Study of modifications induced by thermal and oxidative treatment in oligo and polysaccharides of coffee by mass spectrometry." Doctoral thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17074.

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Doutoramento em Bioquímica<br>Os polissacarídeos são os componentes maioritários dos grãos de café verde e torrado e da bebida de café. Os mais abundantes são as galactomananas, seguindo-se as arabinogalactanas. Durante o processo de torra, as galactomananas e arabinogalactanas sofrem modificações estruturais, as quais estão longe de estar completamente elucidadas devido à sua diversidade e à complexidade estrutural dos compostos formados. Durante o processo de torra, as galactomananas e arabinogalactanas reagem com proteínas, ácidos clorogénicos e sacarose, originando compostos castanh

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10

Stenby, Ejsing Christer. "Molecular characterization of the lipidome by mass spectrometry." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1172770038324-91461.

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Cells, whether bacterial, fungal or mammalian, are all equipped with metabolic pathways capable of producing an assortment of structurally and functionally distinct lipid species. Despite the structural diversity of lipids being recognized and correlated to specific cellular phenomena and disease states, the molecular mechanisms that underpin this structural diversity remain poorly understood. In part, this is due to the lack of adequate analytical techniques capable of measuring the structural details of lipid species in a direct, comprehensive and quantitative manner. The aim of my thesis st

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11

Stenby, Ejsing Christer. "Molecular characterization of the lipidome by mass spectrometry." Doctoral thesis, Technische Universität Dresden, 2006. https://tud.qucosa.de/id/qucosa%3A25015.

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Cells, whether bacterial, fungal or mammalian, are all equipped with metabolic pathways capable of producing an assortment of structurally and functionally distinct lipid species. Despite the structural diversity of lipids being recognized and correlated to specific cellular phenomena and disease states, the molecular mechanisms that underpin this structural diversity remain poorly understood. In part, this is due to the lack of adequate analytical techniques capable of measuring the structural details of lipid species in a direct, comprehensive and quantitative manner. The aim of my thesis st

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12

DONG, YONGHUI. "Mass spectrometry imaging: looking fruits at molecular level." Doctoral thesis, country:IT, 2014. http://hdl.handle.net/10449/24270.

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Mass spectrometry imaging (MSI) is a MS-based technique. It provides a way of ascertaining both spatial distribution and relative abundance of a large variety of analytes from various biological sample surfaces. MSI is able to generate distribution maps of multiple analytes simultaneously without any labeling and does not require a prior knowledge of the target analytes, thus it has become an attractive molecular histology tool. MSI has been widely used in medicine and pharmaceutical fields, while its application in plants is recent although information regarding the spatial organization of me

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13

Dong, Yonghui. "Mass Spectrometry Imaging: Looking Fruits at Molecular Level." Doctoral thesis, Università degli studi di Trento, 2014. https://hdl.handle.net/11572/368984.

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Mass spectrometry imaging (MSI) is a MS-based technique. It provides a way of ascertaining both spatial distribution and relative abundance of a large variety of analytes from various biological sample surfaces. MSI is able to generate distribution maps of multiple analytes simultaneously without any labeling and does not require a prior knowledge of the target analytes, thus it has become an attractive molecular histology tool. MSI has been widely used in medicine and pharmaceutical fields, while its application in plants is recent although information regarding the spatial organization of me

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14

Dong, Yonghui. "Mass Spectrometry Imaging: Looking Fruits at Molecular Level." Doctoral thesis, University of Trento, 2014. http://eprints-phd.biblio.unitn.it/1286/1/Thesis_Yonghui_Dong.pdf.

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Mass spectrometry imaging (MSI) is a MS-based technique. It provides a way of ascertaining both spatial distribution and relative abundance of a large variety of analytes from various biological sample surfaces. MSI is able to generate distribution maps of multiple analytes simultaneously without any labeling and does not require a prior knowledge of the target analytes, thus it has become an attractive molecular histology tool. MSI has been widely used in medicine and pharmaceutical fields, while its application in plants is recent although information regarding the spatial organization of me

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15

Fornai, L. "Molecular Imaging of the heart by mass spectrometry." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421675.

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BACKGROUND Cardiovascular diseases are the world’s number one death cause, accounting for 17.1 million deaths a year. There is still much unknown about cardiovascular diseases and their physiological underlying mechanism. Understanding the nature of complex biological processes occurring in both healthy and diseased heart tissue requires identifying the compounds involved and determining where they are located. Summary METHODS We have investigated a complementary mass spectrometry imaging (MSI) approach using matrix-assisted laser desorption/ionization (MALDI) and secondary ion mass spe

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16

Boiteau, Rene M. "Molecular determination of marine iron ligands by mass spectrometry." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103259.

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Thesis: Ph. D., Joint Program in Oceanography (Massachusetts Institute of Technology, Department of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution), 2016.<br>Page 231 blank. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Marine microbes produce a wide variety of metal binding organic ligands that regulate the solubility and availability of biologically important metals such as iron, copper, cobalt, and zinc. In marine environments where the availability of iron limits microbial growth and carbon fixation rates, the abi

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17

Kim, Yong-Dal. "Accelerator Mass Spectrometry Studies of Highly Charged Molecular Ions." Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc279004/.

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The existence of singly, doubly, and triply charged diatomic molecular ions was observed by using an Accelerator Mass Spectrometry (AMS) technique. The mean lifetimes of 3 MeV boron diatomic molecular ions were measured. No isotopic effects on the mean lifetimes of boron diatomic molecules were observed for charge state 3+. Also, the mean lifetime of SiF^3+ was measured.

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18

Richardson, Jerry Christopher. "Transport, vaporization, and ionization in particle beam liquid chromatography/mass spectrometry interfacing." Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/30974.

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19

Baxter, Christina M. "Development of a low-flow particle beam interface for enviromental mass spectrometry." Diss., Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/30656.

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20

Watson, R. Craig Jr. "Laser-Ionization Time-of-Flight Mass Spectrometry of High Molecular Mass Inorganic Complexes." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/35554.

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Laser-Ionization Time-of-Flight Mass Spectrometry (LI-TOF-MS) is a sophisticated tool for the molecular-weight determination and structural characterization of a variety of molecules. Advances in instrumentation and ionization methods have recently expanded its role in the analysis of high-mass analytes. Large multimetallic complexes, which are efficient solar-energy converters, rely heavily on their chemical structure for optimum operation. Molecular mass determinations of these multimetallic complexes have been problematic due to their lability and high molecular weights. <p> This thesi

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21

Kuzema, P. O., M. Ya Dovzhyk, and O. S. Kuzema. "Main Stages of Development and Recent Advances of Mass Spectrometry." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/42625.

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It has been presented the review and analysis of the main evolution stages of one of the most efficient methods for investigation of composition and properties of substances – mass spectrometry. The advantages and application area of the method were described, as well as physical and technical peculiarities of the devices for its realization were considered.

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22

Harris, William Eric. "Characterization of transport and vaporization processes in particle beam liquid chromatography/mass spectrometry." Diss., Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/30564.

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23

Burdette, Diana Marguerite. "Interfacing packed column supercritical fluid chromatography with mass spectrometry using the particle beam interfaceBurdette." Thesis, Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/27555.

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24

Undin, Torgny. "Characterization of Molecular Adsorption Using Liquid Chromatography and Mass Spectrometry." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-249003.

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Molecular adsorption is a key feature in several disciplines of chemistry, covering as diverse fields as chromatographic separation to biomaterial development. This thesis aims at developing methods and techniques for the characterization of molecular adsorption at the liquid-solid interface. Two different experimental models were used, small molecular interaction characterization using liquid chromatography and complex protein adsorption on polymeric materials possible for biological sampling. Holistic approaches, where both detailed molecular interactions and identifications of trends, could

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25

Gallimore, Peter James. "Molecular characterisation of organic aerosols using soft ionisation mass spectrometry." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709386.

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26

Wright, Scott Jason. "In situ molecular analysis using two-step laser mass spectrometry." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/11612.

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The work described in this thesis is concerned with the development of laser desorption laser photoionisation mass spectrometry (L2MS) towards spatially resolved analysis of real complex molecular systems. A broad overview of the main elements of the technique is presented. In addition, the experimental procedures and equipment used to carry out this work are described in some detail. Photoionisation mass spectra recorded for a series of azo dyes and porphyrin pigments revealed a marked wavelength dependence in their ionisation and fragmentation channels. The relationship between this behaviou

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27

Sookdeo, Adam. "The Determination of 210Pb by Accelerator Mass Spectrometry." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32010.

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The aim of thesis was to establish a methodology for 210Pb measurements by Accelerator Mass Spectrometry (AMS). The potential application is to measure 210Pb in people who have been exposed to radon. This will better our understanding of radon toxicity, which is not possible now with current radiometric and mass spectrometry techniques. The determination of 210Pb by AMS was done in two major studies 1) Studying Pb chemistry in a Cs+ sputter source used in AMS and 2) Evaluating 204,205 & 208Pb spikes for the quantification of 210Pb by isotope dilution. Pb chemistry was investigated using an 834

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28

Rennie, Emma E. "Decay mechanisms of photoexcited molecular ions." Thesis, Heriot-Watt University, 1997. http://hdl.handle.net/10399/658.

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29

Ekroos, Kim. "Characterization of Molecular Glycerophospholipids by Quadrupole Time-of-Flight Mass Spectrometry." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1071755489156-08653.

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The physical properties of glycerophospholipids (GPLs) are not only determined by the head group (HG), but also by their fatty acid (FA) chains, which affect their distribution and function within membranes in the cell. Understanding the microheterogenity of lipid membranes on a molecular level requires qualitative and quantitative characterization of individual lipids and identification of their FA moieties. The aim of my study was to introduce the new technology of multiple precursor ion scanning (MPIS) on a QSTAR Pulsar time-of-flight mass spectrometer (QqTOF) to analyze lipids. Detailed in

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30

Dmitriev, Artëm. "Kinetic study of ester biofuels in flames." Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0238.

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Le progrès partout dans le monde nécessite une variété de sources d'énergie propre. Les biocarburants liquides de type ester semblent être très efficaces dans ce contexte, car ils sont faciles à utiliser dans les véhicules modernes, ils peuvent être produits à partir de diverses ressources renouvelables et ils offrent des caractéristiques de combustion respectueuses de l'environnement. À cet égard, les esters éthyliques d'acides gras (EEAG) sont considérés comme une classe prometteuse de biocarburants. L'objectif principal de cette thèse était de développer un mécanisme cinétique chimique actu

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31

Tito, Mark Anthony. "Assembly of macromolecular complexes examined by electrospray ionisation mass spectrometry." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365340.

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32

Rabus, Jordan. "Mass Spectrometry of Carbohydrates by Experimental and Theoretical Methods." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1628688928273698.

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33

Cerruti, Laura F. "Evaluation of a particle beam interface for LC/MS." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/44624.

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<p>The performance of a Hewlett Packard Particle Beam LC/MS interface is evaluated using EPA appendix VIII and IX compounds. The behavior of these priority pollutants in the interface could determine its feasibility as a future EPA certified technique.</p> <p>The evaluation process consists of studies to determine minimum detectable quantities (MDQ), linear response, and band broadening contributions. The MDQ's of the analytes in electron impact and chemical ionization modes are extrapolated from experimental signal to noise data. The linearity study involves ten compounds analyzed

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34

Théberge, Roger. "An investigation of the beam-induced dehalogenation process in liquid secondary ion mass spectrometry." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq26743.pdf.

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35

White, John. "The determination of trace organic micro-pollutants by particle beam liquid chromatography mass spectrometry." Thesis, Sheffield Hallam University, 2000. http://shura.shu.ac.uk/20526/.

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Liquid Chromatography/ Mass Spectrometry (LC/MS) is used to interface the separating power of LC with the sensitivity and specificity of MS for the determination of trace levels of organic compounds in a variety of matrices. The technique is finding increasing application in the field of environmental and pharmaceutical analysis. Particle Beam LC/MS (PB/LC/MS) uses a particle beam interface to connect the LC to the MS. This interface design has the advantage of being able to produce "classical" electron impact (El) spectra which can then be searched against commercial MS libraries. The aim of

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36

Li, Libing. "Strategies for secondary ion yield enhancements in focused ion beam secondary ion mass spectrometry." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/11806.

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37

Perumal, Karthick. "Epitaxial growth of Ge-Sb-Te based phase change materials." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16815.

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Ge-Sb-Te basierte Phasenwechselmaterialen sind vielersprechende Kandidaten für die Anwendung in optischen und elektrischen nicht-flüchtigen Speicheranwendungen. Diese Materialien können mit Hilfe von elektrischen oder optischen Pulsen reversibel zwischen der kristallinen und amorphen Struktur geschaltet werden. Diese stukturellen Phasen zeigen einen großen Unterschied in ihren elektronischen Eigenschaften, der sich in einer starken Änderung der optischen Reflektivität und des elektrischen Widerstands zeigt.Diese Studie befasst sich mit epitaktischem Wachstum und Analyse der epitaktischen Schi

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38

De, Brabandere Heidi. "Organic Phosphorus Compounds in Aquatic Sediments : Towards Molecular Identification with Mass Spectrometry." Doctoral thesis, Uppsala universitet, Institutionen för fysikalisk och analytisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9319.

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Phosphorus (P) regulates trophic status in most aquatic systems. However, only bioavailable P contributes to primary production. In most lakes and shallow seas, mineralisation of sediment P into its bioavailable form and its release to the water column is important for maintaining primary production. Sediment organic P forms a substantial proportion of this P to be mineralised and can originate from different sources on land (farmland, forests, etc.) or from primary production in the lake. These organic P forms can thus be expected to have differing composition, degradability and recyclable P

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39

Bennet, Francesca Chemical Sciences &amp Engineering Faculty of Engineering UNSW. "Studying polymer degradation at a molecular level via soft ionisation mass spectrometry." Publisher:University of New South Wales, 2009. http://handle.unsw.edu.au/1959.4/43692.

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The present study employs a range of soft-ionisation mass spectrometry techniques to study the degradation of model compounds of poly(methyl methacrylate), poly(n-butyl acrylate) and poly(2-hydroxyethyl methacrylate) under conditions designed to simulate the worst-case scenario that would be experienced by a polymer used in a surface coating on a steel roof. Vinyl-terminated and saturated polymers were degraded for periods of up to 2 years under simulated solar radiation at a temperature of 95??C, temperature of 95 ??C in the dark, and simulated solar radiation at 35??C. Similar degradation m

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40

Arnberg, Elise. "Investigation of molecular probes for pH determination with electrospray ionization mass spectrometry." Thesis, Uppsala universitet, Institutionen för kemi - BMC, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-381962.

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41

Carr, R. H. "High sensitivity stable carbon isotope ratio mass spectrometry : instrument development application." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303835.

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42

Blair, Sheryl McCutcheon. "Evaluation of metal complexation in molecular recognition using quadrupole ion trap mass spectrometry /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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43

Chaput, Dale. "Mass Spectrometry-Based Investigation of APP-Dependent Mechanisms in Neurodegeneration." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5921.

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Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly, and as the aging population increases the social and economic burden of AD grows substantially. Pathological hallmarks of AD include the accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles (NFTs), as well as significant neuron loss. Amyloid plaques consist of aggregated amyloid beta (Aβ) peptide, which is generated from the proteolytic processing of amyloid precursor protein (APP) in addition to several other peptides. While the processing of APP has been characterized, it

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44

Sui, Ping. "Molecular Signatures of Neuropathic Pain : Revealing Pain-Related Signaling Processes in Spinal Cord Using Mass Spectrometric Methodologies." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251334.

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In this thesis, the detection of global proteomics alteration and changes in neuropeptide distribution caused by neuropathic pain in rat spinal cord tissue was the main focus. Neuropathic pain (NP) is a major clinical syndrome caused by disease or dysfunction of the nervous system and often mediated by neuronal networks in the spinal cord. The estimated prevalence of NP is 6-8% in general population. Only in the United States, the indirect cost associated with chronic pain has been estimated to 100 billion dollars each year and NP substantially contributes to this cost. So far, the underlying

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45

Flowers, Antwoine. "Mass-spectrometry Based Proteomics of Age-related Changes in Murine Microglia." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6840.

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The last century has seen a steady increase in the extension of the average lifespan. This has concomitantly produced higher incidences of age-related chronic degenerative diseases like Alzheimer’s and Parkinson’s diseases. Age is the single greatest risk factor for the development of not just these degenerative conditions but cancer as well. The aged niche undergoes a number of maladaptive changes that allow underlying conditions to present and progress. Exactly which changes, contribute to the progression of which disease is currently an area of intense study. However, these answers oft

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46

Wood, Erin. "Analysis of high molecular weight organic compounds in ambient aerosols using mass spectrometry." Diss., Connect to online resource, 2005. http://wwwlib.umi.com/cr/colorado/fullcit?p1427784.

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47

Lopez, Sanchez Susana. "Identification of high molecular weight polycyclic aromatic hydrocarbons by chromatography and mass spectrometry." Diss., Georgia Institute of Technology, 1985. http://hdl.handle.net/1853/27115.

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48

Finch, Jeffrey William. "Selective mass spectrometry by single-photon ionization from a molecular hydrogen laser source." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185895.

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A molecular hydrogen laser, with an output of 7.8 eV photons in the vacuum ultraviolet, is evaluated as a selective source for photoionization mass spectrometry. Types of compounds ionized by the laser include a variety of amines, nitrogen heterocycles, drugs of abuse, pharmaceuticals, and polynuclear aromatic hydrocarbons (PAHS). The laser is coupled to a time-of-flight mass analyzer, which allows a spectrum to be recorded with each laser pulse. The laser is a "soft" ionization source and mass spectra of nearly all of the compounds studied yield single ion peaks due to the parent molecule wit

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49

PIGA, ISABELLA. "Proteomics tools and mass spectrometry imaging techniques for the molecular characterization of pancreas." Doctoral thesis, Università di Siena, 2016. http://hdl.handle.net/11365/1007351.

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The pancreas is a large glandular organ with mixed exocrine and endocrine functions, located in the abdominal cavity behind the stomach. The endocrine portion, 1-2 % of its total volume, is represented by islets of Langerhans and plays a significant role in the pathophysiology of diabetes. The islets mainly contain β cells, which produce and release the hormonal protein insulin into the bloodstream in order to reduce glucose concentrations in the blood [1]. Dysfunction of this regulatory mechanism can lead to the development of type 2 diabetes mellitus (T2DM), a chronic metabolic disorder char

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50

Lagache, Laurine. "Visualizing the molecular interaction networklevel heterogeneity of malignant tumors by mass spectrometry imaging." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2024/2024ULILS111.pdf.

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Le cancer est la deuxième cause de décès dans le monde, avec 10 millions de morts et 19 millions de nouveaux cas en 2020. Le cancer du sein, le plus fréquent chez les femmes, comptait 2,26 millions de cas et près de 685 000 décès cette même année, soulignant l'urgence de recherches ciblées. Le diagnostic repose souvent sur des biopsies analysées histopathologiquement pour identifier les caractéristiques moléculaires des cellules cancéreuses. En fonction de l'expression de certains biomarqueurs (récepteurs hormonaux, oncoprotéines, récepteurs de facteurs de croissance), les sous-types de cancer

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