Relevant bibliographies by topics / Molecular biology, Hematopoiesis, Gene regulation

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Molecular biology, Hematopoiesis, Gene regulation'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Molecular biology, Hematopoiesis, Gene regulation"

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de Rooij, Laura P. M. H., Derek C. H. Chan, Ava Keyvani Chahi, and Kristin J. Hope. "Post-transcriptional regulation in hematopoiesis: RNA binding proteins take control." Biochemistry and Cell Biology 97, no. 1 (2019): 10–20. http://dx.doi.org/10.1139/bcb-2017-0310.

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Normal hematopoiesis is sustained through a carefully orchestrated balance between hematopoietic stem cell (HSC) self-renewal and differentiation. The functional importance of this axis is underscored by the severity of disease phenotypes initiated by abnormal HSC function, including myelodysplastic syndromes and hematopoietic malignancies. Major advances in the understanding of transcriptional regulation of primitive hematopoietic cells have been achieved; however, the post-transcriptional regulatory layer that may impinge on their behavior remains underexplored by comparison. Key players at
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Stellrecht, C. M., G. Fraizer, C. Selvanayagam, L. Y. Chao, A. Lee, and G. F. Saunders. "Transcriptional regulation of a hematopoietic proteoglycan core protein gene during hematopoiesis." Journal of Biological Chemistry 268, no. 6 (1993): 4078–84. http://dx.doi.org/10.1016/s0021-9258(18)53582-1.

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Choi, Kyunghee. "Hemangioblast development and regulation." Biochemistry and Cell Biology 76, no. 6 (1998): 947–56. http://dx.doi.org/10.1139/o99-007.

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Hematopoietic and endothelial cell lineages are the first to mature from mesoderm in the developing embryo. However, little is known about the molecular and (or) cellular events leading to hematopoietic commitment. The recent applications of technology utilizing gene targeted mice and the employment of many available in vitro systems have facilitated our understanding of hematopoietic establishment in the developing embryo. It is becoming clear that embryonic hematopoiesis occurs both in the extra-embryonic yolk sac and within the embryo proper in the mouse. The existence of the long pursued h
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Gandillet, Arnaud, Alicia G. Serrano, Stella Pearson, Michael Lie-A-Ling, Georges Lacaud, and Valerie Kouskoff. "Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification." Blood 114, no. 23 (2009): 4813–22. http://dx.doi.org/10.1182/blood-2009-06-226290.

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Abstract The molecular mechanisms that regulate the balance between proliferation and differentiation of precursors at the onset of hematopoiesis specification are poorly understood. By using a global gene expression profiling approach during the course of embryonic stem cell differentiation, we identified Sox7 as a potential candidate gene involved in the regulation of blood lineage formation from the mesoderm germ layer. In the present study, we show that Sox7 is transiently expressed in mesodermal precursors as they undergo specification to the hematopoietic program. Sox7 knockdown in vitro
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Gu, Yi, Michael C. Byrne, Nivanka C. Paranavitana, et al. "Rac2, a Hematopoiesis-Specific Rho GTPase, Specifically Regulates Mast Cell Protease Gene Expression in Bone Marrow-Derived Mast Cells." Molecular and Cellular Biology 22, no. 21 (2002): 7645–57. http://dx.doi.org/10.1128/mcb.22.21.7645-7657.2002.

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ABSTRACT Rho family GTPases activate intracellular kinase cascades to modulate transcription of multiple genes. Previous studies have examined the roles of the ubiquitously expressed Rho GTPase, Rac1, in regulation of gene expression in cell lines and implicated NF-κB, serum response factor, and kinase signaling pathways in this regulation. To understand the role of the closely related but hematopoiesis-specific Rho GTPase, Rac2, in regulation of gene transcription, we compared the gene expression profiles between wild-type and Rac2−/− bone marrow-derived mast cells. Our data demonstrate remar
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Liao, Eric C., Nikolaus S. Trede, David Ransom, Augustin Zapata, Mark Kieran, and Leonard I. Zon. "Non-cell autonomous requirement for thebloodlessgene in primitive hematopoiesis of zebrafish." Development 129, no. 3 (2002): 649–59. http://dx.doi.org/10.1242/dev.129.3.649.

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Vertebrate hematopoiesis occurs in two distinct phases, primitive (embryonic) and definitive (adult). Genes that are required specifically for the definitive program, or for both phases of hematopoiesis, have been described. However, a specific regulator of primitive hematopoiesis has yet to be reported. The zebrafish bloodless (bls) mutation causes absence of embryonic erythrocytes in a dominant but incompletely penetrant manner. Primitive macrophages appear to develop normally in bls mutants. Although the thymic epithelium forms normally in bls mutants, lymphoid precursors are absent. Noneth
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Contreras, Jorge R., Thilini Fernando, Tiffany M. Tran, et al. "Molecular Characterization of Long Non-Coding RNA CASC15 in Leukemogenesis." Blood 128, no. 22 (2016): 5103. http://dx.doi.org/10.1182/blood.v128.22.5103.5103.

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Abstract High throughput transcriptome sequencing has uncovered a previously uncharacterized layer of gene regulation by long non-coding RNAs (lncRNAs). LncRNAs are characterized by capped, polyadenylated, and spliced transcripts that lack an open reading frame. Despite the similarities in their genetic organization, they play variety of roles at the cellular level, including regulation of transcription and translation, leading to alterations in gene expression. One of these functions is the regulation of expression of chromosomally adjacent genes. Here, we examined the function of the lncRNA
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Guo, Fukun, Wei Liu, Kankana Chava, et al. "Role of mTOR in Hematopoiesis and Hematopoietic Stem Cell Regulation." Blood 114, no. 22 (2009): 1490. http://dx.doi.org/10.1182/blood.v114.22.1490.1490.

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Abstract Abstract 1490 Poster Board I-513 The mammalian target of rapamycin (mTOR) integrates nutrients, growth factors, and cellular energy status to control protein synthesis that determines cell growth and metabolism. It is also known that mTOR plays an essential role in cell survival by regulating Akt/PKB signaling. By using the inhibitor rapamycin, mTOR has previously been suggested to regulate proliferation of megakaryocyte progenitors and late stage of megakaryocyte differentiation without a general impact on normal hematopoiesis or hematopoietic stem cell (HSC) function. Due to limitat
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SAHA, Nirmalya, James Ropa, Lili Chen, et al. "The PAF1c Subunit Cdc73 Is Essential for Hematopoiesis and Displays Differential Gene Regulation in MLL-AF9 Driven Leukemia." Blood 132, Supplement 1 (2018): 1280. http://dx.doi.org/10.1182/blood-2018-99-118703.

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Abstract The Polymerase Associated Factor 1 complex (PAF1c) functions at the interface of epigenetics and gene transcription. The PAF1c is a multi-protein complex composed of Paf1, Cdc73, Leo1, Ctr9, Rtf1 and WDR61, which have all been shown to play a role in disease progression and different types of cancer. Previous reports demonstrated that the PAF1c is required for MLL-fusion driven acute myeloid leukemia. This is due, in part, to a direct interaction between the PAF1c and wild type MLL or MLL fusion proteins. Importantly, targeted disruption of the PAF1c-MLL interaction impairs the growth
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He, XY, VP Antao, D. Basila, JC Marx, and BR Davis. "Isolation and molecular characterization of the human CD34 gene." Blood 79, no. 9 (1992): 2296–302. http://dx.doi.org/10.1182/blood.v79.9.2296.2296.

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Abstract The human CD34 surface antigen is selectively expressed on hematopoietic stem/progenitor cells, suggesting that it plays an essential role in early hematopoiesis. Using a 1.5-kb partial human CD34 cDNA sequence, RNA-polymerase chain reaction (PCR), and rapid amplification of cDNA ends (RACE) methods, we cloned and sequenced the full-length (2.65 kb) cDNA. The cDNA encodes a type I transmembrane protein with no obvious homology to other known proteins. The entire CD34 gene of 28 kb was cloned, and the coding sequences mapped to eight exons. Mapping of the 5′ termini of mRNAs by 5′-RACE
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Dissertations / Theses on the topic "Molecular biology, Hematopoiesis, Gene regulation"

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CANTU', CLAUDIO. "The Sox6 transcription factor: its role in human and murine erythroid differentiation and mechanisms for its regulation." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/8374.

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To identify new genes functionally involved in erythropoiesis during development and maturation, we analysed by DNA microarray three cell populations of different maturity during mouse fetal liver development (E11.5 - E13.5). Among genes whose expression increases in parallel with erythroid maturation there is Sox6, a member of the Sry–related transcription factors family. Sox6 is known to play a major role in erythropoiesis: its ablation in mouse causes a strong relative increase of the expression of embryonic (εy) versus other non-alpha globin genes in late gestation, and a high number of
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Martin, Richard. "Regulation of SCL expression and function in hematopoiesis." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85582.

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The development of the hematopoietic system occurs in two waves: a first wave of primitive erythropoiesis, which consists in the production of a single lineage, primitive erythrocytes, and a second wave of definitive hematopoiesis, which describes the generation of many specialized blood cell types from common hematopoietic stem cells. Whereas definitive hematopoiesis is fairly well understood, involves signals from the environment and the expression of lineage-specific transcription factors, the molecular mechanisms regulating primitive erythropoiesis remain to be defined. The aim of t
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Xu, Yong Zhong. "Molecular mechanisms of regulation of SLC11A1 gene expression." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121167.

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Solute carrier family 11 member 1 protein (SLC11A1), also known as natural resistance-associated macrophage protein 1 (NRAMP1), plays an important role in the host immune defense and inflammatory response. It is a highly conserved transmembrane protein which transports divalent metal cations in a proton-dependent manner. It regulates iron homeostasis in macrophages and exerts pleiotropic effects on macrophage activation. In mice, natural resistance or susceptibility to a range of intracellular pathogens is controlled by the Slc11a1 gene. In human, genetic polymorphisms of the SLC11A1 gene have
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Sutherland, Leslie C. "Transcriptional regulation of the murine PGK-1 gene." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/10111.

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The gene encoding the glycolytic enzyme phosphoglycerate kinase is transcriptionally regulated at two levels. Expression of enzyme is related to the glycolytic activity of the cell, and is highest in transcriptionally active cells. Expression is also regulated by X chromosome inactivation, as the somatically expressed Pgk-1 gene is X-linked. The role of 5$\sp\prime$-flanking cis-acting DNA elements and trans-acting factors in the regulation of Pgk-1 expression was examined. The murine Pgk-1 gene contains an upstream activator sequence (UAS) in its 5$\sp\prime$-flanking region. This region was
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Bakopanos, Evangelos. "Regulation of the 3-adrenergic receptor gene expression." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38148.

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The beta3-adrenergic receptor (beta3-AR) represents a very attractive target for the development of anti-obesity drugs. Selective agonists have been developed based on the rodent beta3-AR and successfully used to treat obesity and Type 2 diabetes in these animals. In humans, however, these particular compounds appear to be less effective and not as specific for the beta3-AR as they are in rodents. An additional problem is the low level of expression of these receptors in human adipose, which may ultimately limit the clinical use of stronger more specific agonists. The objective of this researc
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Argentin, Stefania. "Transcriptional regulation of the rat atrial natriuretic factor gene." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74556.

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Atrial natriuretic factor (ANF), a 28 amino acid peptide hormone, is the major secretory product of the heart. Because of its diuretic, natriuretic and vasodilating activities, this peptide may be involved in the maintenance of proper fluid and electrolyte balance and blood pressure control. In order to study the transcriptional regulation of ANF, we have isolated the rat ANF gene and we have established a system of cardiocytes in primary cell culture for studies on the hormonal, tissue-specific and developmental regulation of the ANF gene. Using this in vitro system, as have demonstrated that
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Bales, Mark. "Molecular regulation of gene expression in anterior mesendoderm of vertebrates." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280000.

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The signaling pathways that regulate the fate of cells located in the anterior lateral (AL) region of the vertebrate embryo are not well understood. Mesodermal cells in this region will assume the heart muscle phenotype while adjacent endoderm gives rise to foregut tissues such as the liver. The AL endoderm supplies key signaling molecules to promote the survival and differentiation of the precardiac mesoderm. These AL endoderm factors are know to up-regulate transcription factors, such as Nkx2--5, that regulate cardiac genes. However, little is known about how the AL endoderm is patterned and
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Lefebvre, Tania. "Role of USP4 in the regulation of gene expression." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27471.

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USP4 is a deubiquitinating enzyme whose levels have been shown to be elevated in certain human lung tumors. USP4 is thought to possess oncogenic properties due to its ability to promote tumors in nude mice assays. The lack of an overall effect on ubiquitin levels in overexpression studies has led to the hypothesis that USP4 may act on a few select substrates to edit their ubiquitination status. Although the structure/function relationship is more documented, the physiological substrates and role in vivo are not. In order to elucidate the mechanism by which USP4 could potentially exert its tumo
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Garnier, France. "Study of transcription regulation of the gene mdr1." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56986.

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In order to characterize cis-acting sequences and trans-acting factors important in regulating the expression of the mouse mdr1 gene, in vitro DNAsel footprinting experiments were carried out on a mdr1 promoter segment between positions $-$245 and +84, using nuclear protein extracts prepared from cell lines expressing different endogenous amounts of mdr1 mRNAs. Three footprinted sequences were detected on the non-coding strand of the $-$245 to +84 mdr1 promoter fragment (between -77 to -56, between -46 to -24, and between +5 and +15) with nuclear extracts from mdr1 expressing cells (CMT-93, LT
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Canaff, Lucie. "Extracellular calcium-sensing receptor : studies of gene expression and regulation." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85136.

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The calcium-sensing receptor (CaSR), expressed in parathyroid, thyroid and kidney, is essential for maintenance of calcium homeostasis. Extracellular calcium (Ca2+o) affects several hepatic functions including bile secretion, metabolic activity, regeneration, and the response to xenobiotics. We have demonstrated the presence, in hepatocytes, of a functional CaSR. Western blot analysis using a specific CaSR antibody showed staining in both whole liver and hepatocyte extracts. Immunohistochemistry and in situ hybridization of rat liver sections showed expression of CaSR protein and mRNA b
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Books on the topic "Molecular biology, Hematopoiesis, Gene regulation"

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G, Abraham Nader, and Symposium on the Molecular Biology of Hematopoiesis (11th 1998 : Bormio, Italy), eds. Molecular biology of hematopoiesis 6. Kluwer Academic/Plenum Publishers, 1999.

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S, Sohal R., Birnbaum Linda S, and Cutler Richard G, eds. Molecular biology of aging: Gene stability and gene expression. Raven Press, 1985.

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1928-, Watson James D., ed. Molecular biology of the gene. 5th ed. Pearson/Benjamin Cummings, 2004.

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1928-, Watson James D., ed. Molecular biology of the gene. 5th ed. Pearson Education, 2004.

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1928-, Watson James D., ed. Molecular biology of the gene. 4th ed. Benjamin/Cummings Pub. Co., 1988.

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1928-, Watson James D., ed. Molecular biology of the gene. 5th ed. Pearson/Benjamin Cummings, 2004.

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1928-, Watson James D., ed. Molecular biology of the gene. 4th ed. Benjamin/Cummings, 1987.

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1928-, Watson James D., ed. Molecular biology of the gene. 6th ed. Pearson/Benjamin Cummings, 2008.

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Collado-Vides, Julio, and Ralf Hofestädt. Gene regulation and metabolism: Postgenomic computational approaches. MIT Press, 2002.

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Laboratory, Cold Spring Harbor, ed. Molecular biology of development. Cold Spring Harbor Laboratory, 1985.

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Book chapters on the topic "Molecular biology, Hematopoiesis, Gene regulation"

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Kobayashi, Ichizo. "Homologous Gene Targeting For Human Gene Therapy." In Molecular Biology of Hematopoiesis 5. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0391-6_42.

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Bina, Minou. "Gene Regulation." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-284-1_1.

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Feder, J. N., D. M. Penny, A. Irrinki, et al. "The Hereditary Hemochromatosis Gene and Iron Homeostasis." In Molecular Biology of Hematopoiesis 6. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4797-6_43.

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Imagawa, Shigehiko, Masayuki Yamamoto, and Yasusada Miura. "Gata Transcription Factors Negatively Regulate Erythropoietin Gene Expression." In Molecular Biology of Hematopoiesis 5. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0391-6_61.

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Rameshwar, Pranela, and Pedro Gascón. "Neural Regulation of Hematopoiesis by the Tachykinins." In Molecular Biology of Hematopoiesis 5. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0391-6_56.

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Shibahara, Shigeki, Kazuhisa Takeda, Shoji Okinaga, Miki Yoshizawa, Kazuhiro Takahashi, and Hiroyoshi Fujita. "Transcriptional Control of the Human Heme Oxygenase-1 Gene by Stress." In Molecular Biology of Hematopoiesis 5. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0391-6_53.

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Nanmoku, Koji, Yasuyoshi Miyao, Masakazu Tamura, et al. "Gene Transfer to the Nervous System Using High-Titer Retroviral Vector." In Molecular Biology of Hematopoiesis 6. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4797-6_37.

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Gruissem, Wilhelm. "Regulation of Plastid Gene Expression." In Plant Molecular Biology. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78852-9_34.

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Shimada, Takashi, and Koichi Miyake. "Targeted Gene Transfer into CD4 Positive Cells by HIV-Based Retroviral Vectors." In Molecular Biology of Hematopoiesis 5. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0391-6_39.

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Kusy, Sophie, and Christopher H. Contag. "Reporter Gene Technologies for Imaging Cell Fates in Hematopoiesis." In Methods in Molecular Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9437-9_1.

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Conference papers on the topic "Molecular biology, Hematopoiesis, Gene regulation"

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"Molecular diagnostics of hearing loss due to mutations in the SLC26A4 gene in indigenous peoples of Southern Siberia (Russia)." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-262.

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"Identification of a novel small RNA encoded in the mouse urokinase receptor uPAR gene (Plaur) and its molecular targets." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-559.

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"Revealing the molecular basis of interactions of COVID-19 with hyperglycemia and diabetic complications based on the bioinformatics analysis of the gene networks." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-520.

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LeDuc, Philip. "Linking Molecular to Cellular Biomechanics With Nano- and Micro-Technology." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43987.

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The link between mechanics and biochemistry has been implicated in a myriad of scientific and medical problem, from orthopedics and cardiovascular medicine, to cell motility and division, to signal transduction and gene expression. Most of these studies have been focused on organ-level issues, yet cellular and molecular level research has become essential over the last decade in this field thanks to the revolutionary developments in genetics, molecular biology, fabrication processes, and biotechnology. Developing the link between molecular and cellular biomechanics through subcellular studies
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Reports on the topic "Molecular biology, Hematopoiesis, Gene regulation"

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Pisitkun, Trairak, Prapaporn Pisitkun, Asada Leelahavanichkul, and Poorichaya Somparn. Systems biology investigation of immune cell regulation at the molecular level in SLE. Faculty of Medicine, Chulalongkorn University, 2018. https://doi.org/10.58837/chula.res.2018.24.

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Autoimmune diseases occur when the immune cells react against self-antigens and subsequently lead to inflammation in the tissues. The interactions between genetics and environmental triggers regulate the phenotypes and outcome of the diseases. Type I interferon has been shown as one of the most crucial cytokines involving in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). SLE is a chronic systemic autoimmune disease which can result in autoantibody production and fatal glomerulonephritis. Activation via nucleic acid sensors can
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Shaw, John, Arieh Rosner, Thomas Pirone, Benjamin Raccah, and Yehezkiel Antignus. The Role of Specific Viral Genes and Gene Products in Potyviral Pathogenicity, Host Range and Aphid Transmission. United States Department of Agriculture, 1992. http://dx.doi.org/10.32747/1992.7561070.bard.

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In this research we have studied the molecular biology of carotenoid biosynthesis in tomato. The investigations focused on the genes Pds and Psy, encoding desaturase and phytoene synthase, respectively, which are key enzymes in the biosynthetic pathway of lycopene and b-carotene. In addition, we have investigated the genes for lycopene cyclase. We have cloned from tomato and characterized the cDNA of CrtL-e, which encodes the lycopene e-cyclase, and analyzed its expression during fruit development. The results establish a paradigm for the regulation of carotenoid pigment biosynthesis during th
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Hirschberg, Joseph, and Gloria A. Moore. Molecular Analysis of Carotenoid Biosynthesis in Plants: Characterizing the Genes Psy, Pds and CrtL-e. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568744.bard.

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In this research we have studied the molecular biology of carotenoid biosynthesis in tomato. The investigations focused on the genes Pds and Psy, encoding desaturase and phytoene synthase, respectively, which are key enzymes in the biosynthetic pathway of lycopene and b-carotene. In addition, we have investigated the genes for lycopene cyclase. We have cloned from tomato and characterized the cDNA of CrtL-e, which encodes the lycopene e-cyclase, and analyzed its expression during fruit development. The results establish a paradigm for the regulation of carotenoid pigment biosynthesis during th
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Bloch, G., and H. S. Woodard. regulation of size related division of labor in a key pollinator and its impact on crop pollination efficacy. United States-Israel Binational Agricultural Research and Development Fund, 2021. http://dx.doi.org/10.32747/2021.8134168.bard.

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Despite the rapid increase in reliance on bumble bees for food production and security, there are many critical knowledge gaps in our understanding of bumble bee biology that limit their colony production, commercial management, and pollination services. Our project focuses on the social, endocrine, and molecular processes regulating body size in the two bumble bee species most important to agriculture: Bombus terrestris in Israel, and B. impatiens in the USA. Variation in body size underline both caste (queen/worker) differentiation and division of labor among workers (foragers are typically
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Horwitz, Benjamin A., and Barbara Gillian Turgeon. Fungal Iron Acquisition, Oxidative Stress and Virulence in the Cochliobolus-maize Interaction. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7709885.bard.

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Our project focused on genes for high affinity iron acquisition in Cochliobolus heterostrophus, a necrotrophic pathogen of maize, and their intertwined relationship to oxidative stress status and virulence of the fungus on the host. An intriguing question was why mutants lacking the nonribosomal peptide synthetase (NRPS) gene (NPS6) responsible for synthesis of the extracellular siderophore, coprogen, are sensitive to oxidative stress. Our overall objective was to understand the mechanistic connection between iron stress and oxidative stress as related to virulence of a plant pathogen to its h
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Shani, Uri, Lynn Dudley, Alon Ben-Gal, Menachem Moshelion, and Yajun Wu. Root Conductance, Root-soil Interface Water Potential, Water and Ion Channel Function, and Tissue Expression Profile as Affected by Environmental Conditions. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7592119.bard.

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Constraints on water resources and the environment necessitate more efficient use of water. The key to efficient management is an understanding of the physical and physiological processes occurring in the soil-root hydraulic continuum.While both soil and plant leaf water potentials are well understood, modeled and measured, the root-soil interface where actual uptake processes occur has not been sufficiently studied. The water potential at the root-soil interface (yᵣₒₒₜ), determined by environmental conditions and by soil and plant hydraulic properties, serves as a boundary value in soil and p
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