Academic literature on the topic 'Molecular hydrogels'

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Journal articles on the topic "Molecular hydrogels"

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Jiang, Hai Ling. "Network Structure and Water Absorption of Soil Moisture Gel by Coarse-Grained Molecular Dynamics Simulations." International Journal of Engineering Research in Africa 63 (March 30, 2023): 1–12. http://dx.doi.org/10.4028/p-r8o1xc.

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With the wide application of hydrogel materials in agriculture, forestry, flexible electronics, electronic information engineering, environmental detection, flexible electronics, information science, technology and so on, the development of various new functional hydrogel materials has gradually become one of the research hotspots. At present, the research on hydrogel materials is mainly focused on the preparation of various functional hydrogels by experimental methods, there is no fundamental understanding of the relationship between the “stimulus-response” and its inner microstructures. In this paper, the author uses the molecular dynamics simulation method to study the evolution of the hydrogel’s microscopic network structure, the relationship between microstructure and water absorption of hydrogels in the processes of water swelling and “stimulus-response”. The next generation of new super absorbent, high toughness, high strength and other functional hydrogels could be synthesized by the guide of this study, and these new hydrogels have a promising future to apply in new fields of technology such as flexible electronics, and biological medicine.
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Wang, Xinyu, Huiyuan Wang, Hongmin Zhang, Tianxi Yang, Bin Zhao, and Juan Yan. "Investigation of the Impact of Hydrogen Bonding Degree in Long Single-Stranded DNA (ssDNA) Generated with Dual Rolling Circle Amplification (RCA) on the Preparation and Performance of DNA Hydrogels." Biosensors 13, no. 7 (July 23, 2023): 755. http://dx.doi.org/10.3390/bios13070755.

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DNA hydrogels have gained significant attention in recent years as one of the most promising functional polymer materials. To broaden their applications, it is critical to develop efficient methods for the preparation of bulk-scale DNA hydrogels with adjustable mechanical properties. Herein, we introduce a straightforward and efficient molecular design approach to producing physically pure DNA hydrogel and controlling its mechanical properties by adjusting the degree of hydrogen bonding in ultralong single-stranded DNA (ssDNA) precursors, which were generated using a dual rolling circle amplification (RCA)-based strategy. The effect of hydrogen bonding degree on the performance of DNA hydrogels was thoroughly investigated by analyzing the preparation process, morphology, rheology, microstructure, and entrapment efficiency of the hydrogels for Au nanoparticles (AuNPs)–BSA. Our results demonstrate that DNA hydrogels can be formed at 25 °C with simple vortex mixing in less than 10 s. The experimental results also indicate that a higher degree of hydrogen bonding in the precursor DNA resulted in stronger internal interaction forces, a more complex internal network of the hydrogel, a denser hydrogel, improved mechanical properties, and enhanced entrapment efficiency. This study intuitively demonstrates the effect of hydrogen bonding on the preparation and properties of DNA hydrogels. The method and results presented in this study are of great significance for improving the synthesis efficiency and economy of DNA hydrogels, enhancing and adjusting the overall quality and performance of the hydrogel, and expanding the application field of DNA hydrogels.
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Chen, Yifan, Weixuan Huang, Yang Chen, Minqian Wu, Ruohan Jia, and Lijun You. "Influence of Molecular Weight of Polysaccharides from Laminaria japonica to LJP-Based Hydrogels: Anti-Inflammatory Activity in the Wound Healing Process." Molecules 27, no. 20 (October 15, 2022): 6915. http://dx.doi.org/10.3390/molecules27206915.

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In this study, polysaccharides from Laminaria japonica (LJP) were produced by the treatment of ultraviolet/hydrogen peroxide (UV/H2O2) degradation into different molecular weights. Then, the degraded LJP were used to prepare LJP/chitosan/PVA hydrogel wound dressings. As the molecular weight of LJP decreased from 315 kDa to 20 kDa, the swelling ratio of the LJP-based hydrogels rose from 14.38 ± 0.60 to 20.47 ± 0.42 folds of the original weight. However, the mechanical properties of LJP-based hydrogels slightly decreased. With the extension of the UV/H2O2 degradation time, the molecular weight of LJP gradually decreased, and the anti-inflammatory activities of LJP-based hydrogels gradually increased. LJP that were degraded for 60 min (60-gel) showed the best inhibition effects on proinflammatory cytokines, while the contents of TNF-α, IL-6, and IL-1β decreased by 57.33%, 44.80%, and 67.72%, respectively, compared with the Model group. The above results suggested that low Mw LJP-based hydrogels showed great potential for a wound dressing application.
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Parelius Jonášová, Eleonóra, and Bjørn Torger Stokke. "Morpholino Target Molecular Properties Affect the Swelling Process of Oligomorpholino-Functionalized Responsive Hydrogels." Polymers 12, no. 2 (January 26, 2020): 268. http://dx.doi.org/10.3390/polym12020268.

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Responsive hydrogels featuring DNA as a functional unit are attracting increasing interest due to combination of versatility and numerous applications. The possibility to use nucleic acid analogues opens for further customization of the hydrogels. In the present work, the commonly employed DNA oligonucleotides in DNA-co-acrylamide responsive hydrogels are replaced by Morpholino oligonucleotides. The uncharged backbone of this nucleic acid analogue makes it less susceptible to possible enzymatic degradation. In this work we address fundamental issues related to key processes in the hydrogel response; such as partitioning of the free oligonucleotides and the strand displacement process. The hydrogels were prepared at the end of optical fibers for interferometric size monitoring and imaged using confocal laser scanning microscopy of the fluorescently labeled free oligonucleotides to observe their apparent diffusion and accumulation within the hydrogels. Morpholino-based hydrogels’ response to Morpholino targets was compared to DNA hydrogels’ response to DNA targets of the same base-pair sequence. Non-binding targets were observed to be less depleted in Morpholino hydrogels than in DNA hydrogels, due to their electroneutrality, resulting in faster kinetics for Morpholinos. The electroneutrality, however, also led to the total swelling response of the Morpholino hydrogels being smaller than that of DNA, since their lack of charges eliminates swelling resulting from the influx of counter-ions upon oligonucleotide binding. We have shown that employing nucleic acid analogues instead of DNA in hydrogels has a profound effect on the hydrogel response.
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Yao, Xue, Xue Gang Luo, and Ben Chao Han. "Synthesis and Characteristics of Interpenetrating Polymer Network Hydrogels Based on Konjac Glucomannan with Different Molecular Weights and Poly(acrylic acid)." Advanced Materials Research 393-395 (November 2011): 1004–7. http://dx.doi.org/10.4028/www.scientific.net/amr.393-395.1004.

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Konjac glucomannan with different molecular weights/poly(acrylic acid) hydrogels were prepared in this paper. The structure of the IPN hydrogels was characterized by FT-IR and SEM. The swelling ratio of these hydrogels showed they had pH-sensitive properties and the enzymatic degradation tests showed the hydrogels retain the enzymatic degradation character of KGM. Furthermore, hydrogel composed of native KGM degraded sharply in enzymatic degradation test and it had bigger swelling ratio and weight loss ratio than those hydrogels which composed of lower molecular weights KGM. Therefore, hydrogels composed of lower molecular weight might release drug more stable when they were used as drug carrier.
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Jiang, Yuheng, Ying Wang, Qin Li, Chen Yu, and Wanli Chu. "Natural Polymer-based Stimuli-responsive Hydrogels." Current Medicinal Chemistry 27, no. 16 (June 4, 2020): 2631–57. http://dx.doi.org/10.2174/0929867326666191122144916.

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The abilities of intelligent polymer hydrogels to change their structure and volume phase in response to external stimuli have provided new possibilities for various advanced technologies and great research and application potentials in the medical field. The natural polymer-based hydrogels have the advantages of environment-friendliness, rich sources and good biocompatibility. Based on their responsiveness to external stimuli, the natural polymer-based hydrogels can be classified into the temperature-responsive hydrogel, pH-responsive hydrogel, light-responsive hydrogel, electricresponsive hydrogel, redox-responsive hydrogel, enzyme-responsive hydrogel, magnetic-responsive hydrogel, multi-responsive hydrogel, etc. In this review, we have compiled some recent studies on natural polymer-based stimuli-responsive hydrogels, especially the hydrogels prepared from polysaccharides. The preparation methods, properties and applications of these hydrogels in the medical field are highlighted.
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Drozdova, Maria, Marina Vodyakova, Tatiana Tolstova, Marina Chernogortseva, Nikita Sazhnev, Tatiana Demina, Nadezhda Aksenova, Peter Timashev, Nataliya Kildeeva, and Elena Markvicheva. "Composite Hydrogels Based on Cross-Linked Chitosan and Low Molecular Weight Hyaluronic Acid for Tissue Engineering." Polymers 15, no. 10 (May 19, 2023): 2371. http://dx.doi.org/10.3390/polym15102371.

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The objectives of the study were as follows: (1) to develop two methods for the preparation of macroporous composite chitosan/hyaluronic acid (Ch/HA) hydrogels based on covalently cross-linked Ch and low molecular weight (Mw) HA (5 and 30 kDa); (2) to investigate some properties (swelling and in vitro degradation) and structures of the hydrogels; (3) to evaluate the hydrogels in vitro as potential biodegradable matrices for tissue engineering. Chitosan was cross-linked with either genipin (Gen) or glutaraldehyde (GA). Method 1 allowed the distribution of HA macromolecules within the hydrogel (bulk modification). In Method 2, hyaluronic acid formed a polyelectrolyte complex with Ch over the hydrogel surface (surface modification). By varying compositions of the Ch/HA hydrogels, highly porous interconnected structures (with mean pore sizes of 50–450 μm) were fabricated and studied using confocal laser scanning microscopy (CLSM). Mouse fibroblasts (L929) were cultured in the hydrogels for 7 days. Cell growth and proliferation within the hydrogel samples were studied via MTT-assay. The entrapment of low molecular weight HA was found to result in an enhancement of cell growth in the Ch/HA hydrogels compared to that in the Ch matrices. The Ch/HA hydrogels after bulk modification promoted better cell adhesion, growth and proliferation than the samples prepared by using Method 2 (surface modification).
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Dannert, Corinna, Bjørn Torger Stokke, and Rita S. Dias. "Nanoparticle-Hydrogel Composites: From Molecular Interactions to Macroscopic Behavior." Polymers 11, no. 2 (February 6, 2019): 275. http://dx.doi.org/10.3390/polym11020275.

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Hydrogels are materials used in a variety of applications, ranging from tissue engineering to drug delivery. The incorporation of nanoparticles to yield composite hydrogels has gained substantial momentum over the years since these afford tailor-making and extend material mechanical properties far beyond those achievable through molecular design of the network component. Here, we review different procedures that have been used to integrate nanoparticles into hydrogels; the types of interactions acting between polymers and nanoparticles; and how these underpin the improved mechanical and optical properties of the gels, including the self-healing ability of these composite gels, as well as serving as the basis for future development. In a less explored approach, hydrogels have been used as dispersants of nanomaterials, allowing a larger exposure of the surface of the nanomaterial and thus a better performance in catalytic and sensor applications. Furthermore, the reporting capacity of integrated nanoparticles in hydrogels to assess hydrogel properties, such as equilibrium swelling and elasticity, is highlighted.
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Vigata, Margaux, Christoph Meinert, Nathalie Bock, Bronwin L. Dargaville, and Dietmar W. Hutmacher. "Deciphering the Molecular Mechanism of Water Interaction with Gelatin Methacryloyl Hydrogels: Role of Ionic Strength, pH, Drug Loading and Hydrogel Network Characteristics." Biomedicines 9, no. 5 (May 19, 2021): 574. http://dx.doi.org/10.3390/biomedicines9050574.

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Water plays a primary role in the functionality of biomedical polymers such as hydrogels. The state of water, defined as bound, intermediate, or free, and its molecular organization within hydrogels is an important factor governing biocompatibility and hemocompatibility. Here, we present a systematic study of water states in gelatin methacryloyl (GelMA) hydrogels designed for drug delivery and tissue engineering applications. We demonstrate that increasing ionic strength of the swelling media correlated with the proportion of non-freezable bound water. We attribute this to the capability of ions to create ion–dipole bonds with both the polymer and water, thereby reinforcing the first layer of polymer hydration. Both pH and ionic strength impacted the mesh size, having potential implications for drug delivery applications. The mechanical properties of GelMA hydrogels were largely unaffected by variations in ionic strength or pH. Loading of cefazolin, a small polar antibiotic molecule, led to a dose-dependent increase of non-freezable bound water, attributed to the drug’s capacity to form hydrogen bonds with water, which helped recruit water molecules in the hydrogels’ first hydration layer. This work enables a deeper understanding of water states and molecular arrangement at the hydrogel–polymer interface and how environmental cues influence them.
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Ščeglovs, Artemijs, and Kristine Salma-Ancane. "Novel Hydrogels and Composite Hydrogels Based on ԑ-Polylysine, Hyaluronic Acid and Hydroxyapatite." Key Engineering Materials 850 (June 2020): 242–48. http://dx.doi.org/10.4028/www.scientific.net/kem.850.242.

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At this work hydrogel and composite hydrogel systems based on ԑ-polylysine (EPL), hyaluronic acid (HA) and nanocrystalline hydroxyapatite (nHAp) were synthesized via chemical cross-linking method followed by in situ precipitation of nHAp into hydrogel copolymer matrix. Molecular structure, phase composition and morphology of EPL-HA and EPL-HA/nHAp systems were investigated using Fourier transform infrared spectroscopy (FTIR), X-ray powder diffractometry (XRD) and scanning electron microscopy (SEM). The fabricated hydrogels and composite hydrogels were evaluated by hydrogels characteristics such as gel fraction and swelling behavior. This study provides a new insight to develop cutting-edge bioactive hydrogels and composite hydrogels for bone tissue engineering as injectable biomaterials due to beneficial properties of system components.
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Dissertations / Theses on the topic "Molecular hydrogels"

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Yang, Zhimou. "Molecular hydrogels : design, synthesis, enzymatic regulation, and biological applications /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202006%20YANG.

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Van, Velzen Vera. "Enhancing the functionality of hydrogels using molecular polymer brushes." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/226153/1/Vera_Van%20Velzen_Thesis.pdf.

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This thesis studies a new approach to enhance the properties of hydrogels using Molecular Polymer Brushes (MPB’S). It examines the morphology of the MPB’s and the GelMA-MPB’s network, the effect of the brushes on the mechanical properties of the hydrogel and the effect of the brushes on the encapsulated cells. In doing so, a new hydrogel is developed, providing new possibilities in the field of cartilage regeneration with the potential to improve treatment for Osteoarthritis.
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Xing, Zhongyang. "DNA scaffolds for functional hydrogels." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/286065.

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DNA scaffolds self-assembled by short-stranded synthetic DNA can be tailored to build thermally reversible hydrogels with target binding sites. These hydrogels exhibit highly selective binding properties due to the specificity of DNA and also provide an aqueous environment for various reactions to happen within the network constraints. Hence, a careful study on the assembly mechanism and other physical aspects of DNA hydrogels is required to facilitate the future design and construction of such materials at the precise control. In this thesis, I present the work on well-designed DNA nano-stars as scaffolds for functional bulk materials with potential applications in bio-sensing. Chapter 1 starts with introducing the fundamental properties of DNA molecules, focusing on the advantages of utilising short-stranded DNA to programme and engineer micro- and macro- materials. Then it briefly reviews the field of rheology and micro-rheology, with the diffusing wave spectroscopy (DWS) technique illustrated explicitly as an example passive micro-rheology tool. Afterwards, a critical literature review on computational modelling of DNA systems is present, followed by the thesis outline at the end. Chapter 2 describes a simple DNA dendrimer system self-assembled from three-armed DNA nano-stars. The characterisation tools such as UV-vis spectroscopy, gel electrophoresis and dynamic light scattering (DLS) are introduced to verify the final production of the complex DNA structures. From this practice, we develop a routine for designing DNA scaffolds that yield optimal productivity. Chapter 3 investigates the mechanical properties of DNA hydrogels made of three-armed DNA nano-stars and how they change upon cooling and heating empolying DWS micro-rheology. The resulting viscoelastic moduli over a broad range of frequencies reveal a clear, temperature-reversible percolation transition coinciding with the melting temperature of the system's sticky ends. This indicates that we can achieve precise control in mechanical properties of DNA hydrogels, which is beneficial for designing more sensitive molecular sensing tools and controlled release systems. Chapter 4 develops a coarse-graining computational model of DNA hydrogels that resembles the system in Chapter 3 using LAMMPS, a classical molecular dynamics code. Thermodynamics, structural analysis and rheology tests were taken, qualitatively reproducing the physical phenomena of DNA assembly of the hydrogel network. Chapter 5 studies the internal behaviours of three-armed DNA complexes using oxDNA model also implemented in LAMMPS, with particular focus on the effect of the inert bases in the core and between double-stranded branches and single-stranded sticky ends. A deep insight into sequence-dependent behaviour of such complex structures can guide the parameter optimisation of the individual building blocks for the model described in Chapter 4. Chapter 6 concludes the thesis and presents an outlook for the future work that emerged out of my experimental and numerical studies.
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Wang, Huifeng. "Molecular Mass Dependent Mechanical Properties of Metal-free Click Hydrogels." University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1427901118.

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Cedano, Serrano Francisco Javier. "From molecular architecture and electrostatic interactions to underwater adherence of hydrogels." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS056.

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Ce travail essaie de décortiquer les multiples paramètres régissant l’adhésion en phase aqueuse de polymères chargés. Nous cherchons d’abord à établir un lien entre les interactions électrostatiques moléculaires et les différentes architectures moléculaires de matériaux gonflés élastiques (Parties I et II) ou viscoélastiques (Partie III), avant de nous intéresser à l’adhésion en milieu immergé. (Partie I) Le premier système modèle de matériaux synthétiques nous a permis de corréler l’architecture moléculaire des hydrogels élastiques, la densité de charge interfaciale, et la force ionique du milieu avec les propriétés adhésives en phase aqueuse, à un niveau macroscopique en utilisant la technique du Probe-tack, et également à un niveau microscopique avec la microscopie à force atomique. (Partie II) Par ailleurs, étant inspirés par les systèmes adhésifs naturels, nous avons cherché à étendre ce système modèle à la mesure d’adhésion macroscopique entre hydrogels de gélatine de charges opposées. Nous montrons que le système modèle permettant de contrôler et de prédire l’adhésion en milieu aqueux en modifiant la densité de charge interfaciale et les propriétés mécaniques du matériau est transposable aux systèmes à base de gélatine. (Partie III) Enfin, nous avons développé un adhésif bio-inspiré entièrement synthétique à base de coacervation complexe. Ce nouveau système d’adhésif associe les interactions électrostatiques avec des domaines thermo-sensibles, donnant ainsi naissance à un matériau prometteur pour l’adhésion en milieu immergé
This work attempts to unravel some of the intricacies of the aqueous adhesion of elastic or viscoelastic highly swollen charged polymers. In Part I the first model synthetic system permitted us to successfully link the molecular architecture of the elastic hydrogels, their interfacial charge density and the ionic strength of the medium with the underwater adhesion properties at a macroscopic level using probe-tack experiments and a microscopic level using atomic force microscopy. In Part II we successfully expanded the synthetic elastic system to measure macroscopic adhesion between oppositely charged gelatin-based hydrogels. Finally, in Part III we developed a synthetic and bio-inspired adhesive based on complex coacervation. This novel adhesive system combines the contribution of electrostatic interactions and thermoresponsive domains resulting in a material with promising properties as an injectable viscoelastic adhesive for medical applications
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Debertrand, Louis. "Fracture of dual-crosslink dynamic hydrogels : from molecular interactions to fracture energy." Electronic Thesis or Diss., Université Paris sciences et lettres, 2020. http://www.theses.fr/2020UPSLS027.

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Ce projet s'insère dans un projet global plus ambitieux dont l'objectif est de comprendre les mécanismes de la propagation d'une fracture au sein d'un matériau mou. Les matériaux étudiés lors de cette thèse seront principalement des hydrogels, "classiques" ou à double réticulation chimique/physique. L'introduction de liens dynamiques permet de retarder la rupture des liens covalents et augmente l'énergie de rupture. A ce jour, il n'existe aucun modèle d'endommagement qui permette de prédire la rupture à partir de la structure moléculaire. L'objectif est donc de combiner différentes techniques pour détecter la rupture à plusieurs échelles. Au niveau macroscopique ce sera la vitesse de propagation d'une fissure et les conditions de son amorçage qui seront étudiées. A l'échelle mésoscopique le champ de déformation en pointe de fissure sera étudié par corrélation d'image ou suivi de particules fluorescentes. A l'échelle moléculaire il sera aussi possible de s'orienter vers l'utilisation de molécules mécanophores, technique déjà appliquée avec succès au sein du laboratoire pour détecter les forces agissant sur les molécules et les ruptures de liaisons
This projects is part of an ambitious global project, which objective is to understand the mechanisms of fracture propagation in a soft material. The materials used during this PhD will mostly be hydrogels, whether with simple or double reticulation (chemical and physical). The introduction of dynamic (physical) bonds allows te delaying of the breaking of covalent (chemical) bonds, and increases the energy of failure. To this day, no model exists that would allow fracture prediction from the molecular structure. The objective of this project is thus to combine different technics to detect breaking at different scales. At macroscopic level, the speed of the fracture propagation and its triggering conditions will be studied. At the mesoscopic scale, the strain field at the fracture tip will be studied by digital image correlation or by the use of fluorescent particles. At the molecular scale, one possibility will be to use mecanophorous molecules, a technique already applied with success within the laboratory to detect the forces acting on molecules and bond breakings
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Xu, Haixia. "An investigation of the conductivity of peptide nanostructured hydrogels via molecular self-assembly." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/an-investigation-of-the-conductivity-of-peptide-nanostructured-hydrogels-via-molecular-selfassembly(cc3d519a-18ca-4ba3-8172-4d7359080610).html.

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Nanoscale, conductive wires fabricated from organic molecules have attracted considerable attention in recent years due to their anticipated applications in the next generation of optical and electronic devices. Such highly ordered 1D nanostructures could be made from a number of routes. One route of particular interest is to self-assemble the wires from biomolecules due to the wide range of assembly methods that can be adapted from nature. For example, biomolecules with aromatic motifs can be self-assembled so that good π-π stacking is achieved in the resultant nanostructure. An additional advantage of using biomolecules is that it enables the interface of the electronic materials with biological systems, which is important for many applications, including nerve cell communication and artificial photosynthesis. In this study, nanowires were prepared by the molecular self-assembly of oligopeptides that were coupled to aromatic components. In order to achieve charge transport though the nanowires, it was imperative that the aromatic components were arranged so that there was π-π stacking with very few structural defects. Therefore, enzymes were used to control the formation of the hydogelators which subsequently self-assembled to produce nanowire networks. Two main systems were studied in this thesis.In the first system, hydrogelators were produced from aromatic peptide amphiphiles via the enzymatic hydrolysis of the methyl ester of fluorenylmethoxycarbonyl (Fmoc)-di/tripeptides. These hydrogelators formed nanostructures due to π-π stacking between the Fmoc groups and H-bonding between the peptides. The nanostructures in turn produced macroscale gel networks. The nanostructures were analyzed by wide angle X-ray diffraction and fluorescence spectroscopy. A combination of Fourier transform infra-red (FTIR), Transmission Electron Microscopy (TEM), Cryo-TEM, and Atomic Force Microscopy (AFM) was used to characterize the networks. The charge transport properties of the dried networks were studied using impedance spectroscopy. Fmoc-L₃ was found to assemble into nanotubes whose walls consisted of 3 self-assembled layers and possessed inner and outer diameters of ~ 9 nm and ~ 18 nm, respectively. The Fmoc-L₃ networks were structurally stabile and were electronically conductive under a vacuum. The sheet resistance of the peptide networks increased with relative humidity due to the increasing ionic conductivity. The resistance of the networks was 0.1 MΩ/sq in air and 500 MΩ/sq in vacuum (pressure: 1.03 mbar) at room temperature. The networks had a band gap of between 1 to 4 eV as measured by UV-Vis spectroscopy and the temperature-impedance studies. Possible routes for aligning the Fmoc-L3 networks were studied in an attempt to improve their conductivity in one direction. In particular, the peptides were assembled under an electric field (0 to 3.75 kV/cm). Random networks were produced at low field strengths, whereas a degree of alignment was obtained at a field strength of 3.75 kV/cm. The conductivity of the aligned networks in the direction of alignment was a factor of three times higher than that of the random networks.The second system studied was Fmoc-dipeptide-OMe hydrogels produced by the enzymatic condensation of an Fmoc-amino acid and an amino acid ester. Preliminary results found that Fmoc-SF-OMe assembled into nanosheets, nanoribbons and spherulites, depending on the temperature at which self-assembly occurred. The Fmoc-XY-OMe films possessed an extremely high resistance (1012 Ω).
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Lago, Manuela Ermelinda Lopes. "Characterization and functionalization of hydrogels for cell culture." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12574.

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Mestrado em Biotecnologia - Biotecnologia Molecular
Mechanotransduction is the response to and/or the production of mechanical stimuli exerted upon, or by cells, that is coupled to biochemical signals. Cells are surrounded by extracellular matrix (ECM) which has specific mechanical properties and composition depending on the tissue. These components bind to and activate integrins, which results in intracellular signaling that involves the actin cytoskeleton and myosin motor proteins. In neurodegenerative diseases, modifications occur in the ECM composition and rigidity that seem to inhibit oligodendrocyte differentiation and remyelination of the affected area. Oligodendrocytes (OLs) are the myelin-producing cells of the central nervous system (CNS). OL differentiation is modulated by, among other factors, ECM proteins like laminin and fibronectin and by substrate rigidity. Cells also sense substrate stiffness when cultured in vitro. In order to mimic this mechanical component, polyacrylamide platforms were created with defined stiffness, considering the stiffness of the target tissue relevant for this study – the brain. These platforms were functionalized with ECM proteins or small peptides (derived from ECM proteins), that allow to study the impact of these factors on cellular differentiation, in contrast with standard cell culture conditions. The main achievement in this study was to maintain and differentiate oligodendrocytes using a fully defined compliant substrate. Several peptides derived from the laminin-alpha2 chain were used, to provide adhesion to the cells and allow their differentiation. This exploratory study suggests that the peptides under study have a potential to be explored in the future using primary cells and fully evaluate their capacity to modulate oligodendrocyte differentiation, namely to understand which biochemical pathways are involved.
Mecanotransdução é a resposta e/ou a produção de um estímulo mecânico exercido sobre ou por células, que é acoplado a sinais bioquímicos. As células estão rodeadas por matriz extracelular (ECM) que tem propriedades mecânicas e de composição específicas, dependendo do tecido. Estes componentes ligam-se a integrinas e activam-nas, resultando em sinalização intracelular que envolve o citoesqueleto de actina e proteínas motoras. Em doenças neurodegenerativas, são observadas modificações na composição da matriz extracelular e da sua rigidez que pode resultar na inibição de diferenciação de oligodendrócitos e de remielinização das áreas afectadas. Os oligodendrócitos (OLs) são células do sistema nervoso central (CNS) responsáveis pela produção de mielina. A sua diferenciação é modulada por, entre outros fatores, proteínas presentes na matriz extracelular como laminina e fibronectina e pela rigidez do substrato. As células são também sensíveis à rigidez do substrato quando cultivadas in vitro. De forma a mimetizar essa componente mecânica, foram criadas plataformas de poli-acrilamida como substrato com rigidez definida, tendo em consideração o tecido que pretendemos mimetizar - o cérebro. Estas plataformas foram funcionalizadas com proteínas da ECM ou pequenos péptidos presentes nessas mesmas proteínas, permitindo estudar e modular a influência destes mesmos fatores na diferenciação celular, em contraste com condições de cultura standard. A principal novidade deste estudo consiste na manutenção e diferenciação de oligodendrócitos in vitro utilizando um substrato compatível e definido. Foram para isso utilizados péptidos derivados da laminina-alfa2, que promoveram a adesão e diferenciação das células. Este estudo exploratório sugere que os péptidos sob estudo têm potencial para ser utilizados no futuro na modulação da diferenciação de células primárias e perceber qual o papel destes nas vias bioquímicas intracelulares envolvidas.
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Saito, Takashi. "DESIGN AND CHARACTERIZATION OF GELATIN HYDROGELS INCORPORATING LOW-MOLECULAR-WEIGHT DRUGS FOR TISSUE REGENERATION." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199334.

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Lee, Seung Geol. "Structure-property relationship of hydrogel: molecular dynamics simulation approach." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44844.

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We have used a molecular modeling of both random and blocky sequence hydrogel networks of poly(N-vinyl-2-pyrrolidone-co-2-hydroxyethyl methacrylate) (P(VP-co-HEMA)) with a composition of VP:HEMA = 37:13 to investigate the effect of the monomeric sequence and the water content on the equilibrium structures and the mechanical and transport properties by full-atomistic molecular dynamics (MD) simulations. The degree of randomness of the monomer sequence for the random and the blocky copolymers, were 1.170 and 0.104, respectively, and the degree of polymerization was fixed at 50. The equilibrated density of the hydrogel was found to be larger for the random sequence than for the blocky sequence at low water contents (< 40 wt %), but this density difference decreased with increasing water content. The pair correlation function analysis shows that VP is more hydrophilic than HEMA and that the random sequence hydrogel is solvated more than the blocky sequence hydrogel at low water content, which disappears with increasing water content. Correspondingly, the water structure is more disrupted by the random sequence hydrogel at low water content but eventually develops the expected bulk-water-like structure with increasing water content. From mechanical deformation simulations, the stress-strain analysis showed that the VP is found to relax more efficiently, especially in the blocky sequence, so that the blocky sequence hydrogel shows less stress levels compared to the random sequence hydrogel. As the water content increases, the stress level becomes identical for both sequences. The elastic moduli of the hydrogels calculated from the constant strain energy minimization show the same trend with the stress-strain analysis. Ascorbic acid and D-glucose were used to study the effect of the monomeric sequence on the diffusion of small guest molecules within the hydrogels. By analyzing the pair correlation functions, it was found that the guest molecule has greater accessibility to the VP units than to the HEMA units with both monomeric sequences due to its higher hydrophilicity compared to the HEMA units. The monomeric sequence effect on the P(VP-co-HEMA) hydrogel is clearly observed with 20 wt % water content, but the monomeric sequence effect is significantly reduced with 40 wt % water content and disappears with 80 wt % water content. This is because the hydrophilic guest molecules are more likely to be associated with water molecules than with the polymer network at the high water content. By analyzing the mean square displacement, the displacement of the guest molecules and the inner surface area, it is also found that the guest molecule is confined in the system at 20 wt % water content, resulting in highly anomalous subdiffusion. Therefore, the diffusion of the guest molecules is directly affected by their interaction with the monomer units, the monomeric sequence and the geometrical confinement in the hydrogel at a low water content, but the monomeric sequence effect and the restriction on the diffusion of the guest molecule are significantly decreased with increasing the water content. We also investigated the de-swelling mechanisms of the surface-grafted poly(N-isopropylacrylamide) (P(NIPAAm)) brushes containing 1300 water molecules at 275 K, 290 K, 320 K, 345 K, and 370 K. We clearly observed the de-swelling of the water molecules for P(NIPAAm) above the lower critical solution temperature (LCST) (~305 K). Below the LCST, we did not observe the de-swelling of water molecules. Using the upper critical solution temperature (UCST) systems (poly(acrylamide) brushes) for comparison purposes, we did not observe the de-swelling of water molecules at a given range of temperatures. By analyzing the pair correlation functions and the coordination numbers, the de-swelling of the water molecules occurred distinctly around the isopropyl group of the P(NIPAAm) brush above the LCST because C(NIPAAm) does not offer sufficient interaction with the water molecules via the hydrogen bonding type of secondary interaction. We also found that the contribution of the N(NIPAAm)-O(water) pair is quite small because of the steric hindrance of the isopropyl group. By analyzing the change in the hydrogen bonds, the hydrogen bonds between polar groups and water molecules in the P(NIPAAm) brushes weaken with increasing temperature, which leads to the de-swelling of the water molecules out of the brushes above the LCST. Below the LCST, the change in the hydrogen bonds is not significant. Again, the contribution of the NH(NIPAAm)-water pairs is insignificant; the total number of hydrogen bonds is ~20, indicating that the interaction between the NH group and the water molecules is not significant due to steric hindrances. Lastly, we observed that the total surface area of the P(NIPAAm) brushes that is accessible to water molecules is decreased by collapsing the brushes followed by the de-swelling of water molecules above the LCST.
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Books on the topic "Molecular hydrogels"

1

Fukai, Yuh. Molecular Hydrogen for Medicine. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-7157-2.

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Sun, Xuejun, Shigeo Ohta, and Atsunori Nakao, eds. Hydrogen Molecular Biology and Medicine. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9691-0.

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Kasai, Hideaki, Allan Abraham B. Padama, Bhume Chantaramolee, and Ryan L. Arevalo. Hydrogen and Hydrogen-Containing Molecules on Metal Surfaces. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6994-4.

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service), SpringerLink (Online, ed. Molecular networks. Berlin: Springer, 2009.

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Culhane, Michael. Hydrogen molecules in SN 1987A. [Washington, DC: National Aeronautics and Space Administration, 1997.

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Julius, Rebek. Hydrogen-bonded capsules: Molecular behavior in small spaces. Hackensack, NJ: World Scientific, 2015.

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Dean, B. Sticking coefficient of molecular and atomic hydrogen on palladium. [S.l.]: [s.n.], 1987.

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Conroy-Lewis, Fiona Margaret. Synthesis and reactivity of molecular hydrogen complexes of Ruthenium. Salford: University of Salford, 1987.

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Barker, D. A. Theoretical studies of hydrogen bonded and weakly bonded molecular complexes. Manchester: UMIST, 1992.

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S, Poluėktov N., ed. n-Ėlektrony geteroatomov v vodorodnoĭ svi͡azi i li͡uminest͡sent͡sii. Moskva: "Nauka", 1985.

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Book chapters on the topic "Molecular hydrogels"

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Košovan, Peter, Tobias Richter, and Christian Holm. "Molecular Simulations of Hydrogels." In Intelligent Hydrogels, 205–21. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01683-2_16.

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Ramirez, Miguel A., and Zhilei Chen. "Split-Intein Triggered Protein Hydrogels." In Methods in Molecular Biology, 161–71. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6451-2_11.

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Ajiro, Hiroharu, and Takamasa Sakai. "Molecular Technology for Degradable Synthetic Hydrogels for Biomaterials." In Molecular Technology, 203–18. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2019. http://dx.doi.org/10.1002/9783527823987.vol2_c10.

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Oh, Keun Sang, and Soon Hong Yuk. "Hydrogels-Based Drug Delivery System with Molecular Imaging." In Biomedical Applications of Hydrogels Handbook, 179–200. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-5919-5_10.

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Abebe, Daniel G., Rima Kandil, Teresa Kraus, Maha Elsayed, Tomoko Fujiwara, and Olivia M. Merkel. "Biodegradable Three-Layered Micelles and Injectable Hydrogels." In Methods in Molecular Biology, 175–85. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3718-9_11.

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Bergamaschi, Greta, Alessandro Strada, Roberto Frigerio, Marina Cretich, and Alessandro Gori. "Self-Assembling Peptide Hydrogels for 3D Microarrays." In Methods in Molecular Biology, 179–89. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-1064-0_14.

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Musicò, Angelo, Greta Bergamaschi, Alessandro Strada, Roberto Frigerio, Paola Gagni, Marina Cretich, and Alessandro Gori. "Hybrid Peptide–Agarose Hydrogels for 3D Immunoassays." In Methods in Molecular Biology, 53–62. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2732-7_5.

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Ahearne, Mark, and Julia Fernández-Pérez. "Fabrication of Corneal Extracellular Matrix-Derived Hydrogels." In Methods in Molecular Biology, 159–68. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0599-8_11.

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Park, Keun-Young, David J. Odde, and Mark D. Distefano. "Photoresponsive Hydrogels for Studying Mechanotransduction of Cells." In Methods in Molecular Biology, 133–53. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2851-5_9.

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Liu, Wengang, Ting-Hsuan Chen, and Jiandong Ding. "Single-Cell Micropatterning by Non-fouling Hydrogels." In Methods in Molecular Biology, 65–70. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3323-6_6.

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Conference papers on the topic "Molecular hydrogels"

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Fatimi, Ahmed, and Chaymaa Hachimi Alaoui. "The International Patent Classification: Case of hydrogels." In MOL2NET'22, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 8th ed. - MOL2NET: FROM MOLECULES TO NETWORKS. Basel, Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/mol2net-08-12452.

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Cadena-Nogales, Ana, Samara Mishelle Ona, Jose Alvarez Barreto, Marco Leon Dunia, Miguel Angel Mendez, and Daniela Viteri. "Poly(vinyl alcohol) (PVA) in hydrogels, a molecular perspective." In 2019 IEEE Fourth Ecuador Technical Chapters Meeting (ETCM). IEEE, 2019. http://dx.doi.org/10.1109/etcm48019.2019.9014900.

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Ruso, Juan, and Ramón Rial. "Rheological properties of bioinspired hybrid hydrogels." In MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/mol2net-07-09539.

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Erikson, Isaac E., Cindy Chung, Jason A. Burdick, and Robert L. Mauck. "Hyaluronic Acid Macromer Concentration Influences Functional MSC Chondrogenesis in Photocrosslinked MSC-Laden Hydrogels." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193096.

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Intrinsic repair of articular cartilage is poor, and so numerous tissue engineering strategies have been developed for producing functional cartilage replacements. Photopolymerizable methacrylated hyaluronic acid (MeHA) hydrogels have been developed as a potential hydrogel that possesses the distinct advantage of being biologically relevant as well as easily modified to generate a range of hydrogel properties [1]. To date, optimization of this hydrogel has been carried out by adjusting macromer molecular weight, concentration, and extent of methacrylation. Recent studies using MeHA hydrogels with auricular chondrocytes have shown that adjustments in these parameters can have significant impact on cell viability and construct maturation. [1, 2].
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Choi, Eunpyo, Indong Jun, Kyung Min Park, Ki Dong Park, Heungsoo Shin, and Jungyul Park. "Controllable in-situ hydrogels membrane formation using microfluidics." In 2011 IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2011. http://dx.doi.org/10.1109/nems.2011.6017387.

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Fatimi, Ahmed. "Patentability of hydrogels as biocompatible coatings for medical device biofabrication." In MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/mol2net-07-10885.

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John, George, Jose James, Malick Samateh, Siddharth Marwaha, and Vikas Nanda. "Sucralose Hydrogels: Peering into the Reactivity of Sucralose versus Sucrose Using Lipase Catalyzed Trans-Esterification." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/xkza4963.

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Sucralose differs from sucrose only by virtue of having three Cl groups instead of OH groups. Its intriguing features include being noncaloric, noncariogenic, 600 times sweeter than sucrose, stable at high temperatures/acidic pH's, and void of disagreeable aftertastes. These properties are attractive as food additive, one of which is as hydrogel obtainable via the technique of molecular gelation using a sucralose-derived low-molecular weight gelator (LMWG). The process of molecular gelation entails using specially designed lipid-like amphiphilic molecules capable of self-assembling in a liquid solvent to form a 3D-network. A rational molecular design would involve appending lipophilic alkyl chain to sucralose to afford sucralose-based amphiphiles. Our preliminary study has shown that sucralose, unlike sucrose, is unreactive under biocatalytic conditions using lipase enzyme, which is consistent with its reported lack of reactivity by hydrolytic enzymes in the body. Hence, the aim of this work was (i) to use computation and simulations to further understand sucralose's lack of enzymatic reactivity and (ii) to synthesize the sucralose-based amphiphiles using conventional chemical synthesis and systematically study their tendency towards hydrogelation. Three of the sucralose-based amphiphiles (SL-5, SL-6 and SL-7) proved to be successful hydrogelators. The gelators also showed the ability to gel selected beverages. The LMWGs gelled quantities of water and beverage up to 71 and 55 times their weight, respectively, and remain thermally stable up to 144 °C.
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Sridhar, M., M. F. Insana, and J. Liu. "4J-1 Towards a Molecular Level Understanding of Elasticity in Tissues and Hydrogels." In 2006 IEEE Ultrasonics Symposium. IEEE, 2006. http://dx.doi.org/10.1109/ultsym.2006.266.

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Huang, Shih-Hao, Hsiao-Tzu Chu, Chih-Wei Wu, and Yun-Yu Chuang. "Light-addressable electrochemical micropatterning of cell-encapsulated alginate hydrogels for cell-based microarray." In 2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2012. http://dx.doi.org/10.1109/nems.2012.6196742.

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Fatimi, Ahmed. "Development and innovation on hydrogels in the world: A scientific overview based on patent applications." In MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/mol2net-07-10884.

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Reports on the topic "Molecular hydrogels"

1

Zhang, W., I. Gaberman, and M. Ciszkowska. Diffusion of Molecular Probes in Thermoresponsive Poly(N-isopropylacrylamide) Hydrogels: Electroanalytical Studies. Fort Belvoir, VA: Defense Technical Information Center, July 2001. http://dx.doi.org/10.21236/ada390102.

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Calef, D. F. Molecular models for the intercalation of hydrogen molecules into modified graphites. Office of Scientific and Technical Information (OSTI), December 1995. http://dx.doi.org/10.2172/212469.

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Crabtree, R. H. Hydrogen Storage by Molecular Polyhydrides. Fort Belvoir, VA: Defense Technical Information Center, November 1987. http://dx.doi.org/10.21236/ada194207.

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Mountain, Raymond D. Molecular dynamics and hydrogen bonds in water. Gaithersburg, MD: National Institute of Standards and Technology, 1997. http://dx.doi.org/10.6028/nist.ir.6028.

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Kozioiziemski, B. Crystal Properties and Radiation Effects in Solid Molecular Hydrogens. Office of Scientific and Technical Information (OSTI), September 2000. http://dx.doi.org/10.2172/15013356.

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Struzhkin, Viktor V., Wendy L. Mao, Ho-Kwang Mao, Burkhard Militzer, and Russell Hemley. Hydrogen Storage in Novel Molecular Materials, Final Report. Office of Scientific and Technical Information (OSTI), May 2006. http://dx.doi.org/10.2172/977587.

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John, Vijay T., Gary L. McPherson, Hank Ashbaugh, and Camille Y. Johnes. Molecular Design Basis for Hydrogen Storage in Clathrate Hydrates. Office of Scientific and Technical Information (OSTI), June 2013. http://dx.doi.org/10.2172/1086498.

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Sahimi, Muhammad. Nanoporous Membranes for Hydrogen Production: Experimental Studies and Molecular Simulations. Office of Scientific and Technical Information (OSTI), December 2013. http://dx.doi.org/10.2172/1151832.

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Wall, Judy D. Genetics and Molecular Biology of Hydrogen Metabolism in Sulfate-Reducing Bacteria. Office of Scientific and Technical Information (OSTI), December 2014. http://dx.doi.org/10.2172/1166017.

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Wall, J. Genetics and molecular biology of hydrogen metabolism in sulfate reducing bacteria. Office of Scientific and Technical Information (OSTI), January 1990. http://dx.doi.org/10.2172/6892389.

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