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Relevant bibliographies by topics / Molecular imaging agent / Dissertations / Theses

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Dissertations / Theses on the topic 'Molecular imaging agent'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Boucher, Marianne. "Magnetosomes used as biogenic MRI contrast agent for molecular imaging of glioblastoma model." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS234/document.

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Ces travaux de thèse s'inscrivent dans le contexte de l'imagerie moléculaire, qui vise à adapter les traitements de pathologies à la variabilité de chaque patient, grâce à l'imagerie de biomarqueurs cellulaires ou moléculaires. En particulier, l'imagerie par résonance magnétique (IRM) couplée a des nanoparticules d’oxyde de fer innovantes pourrait permettre de relever un tel défi.Cette thèse se concentre sur l'étude d'une nouvelle classe d'agents de contraste à base d'oxyde de fer pour l'IRM à haut champ magnétique. En effet, les magnétosomes sont des vésicules d’oxyde de fer produites naturel

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2

Zurkiya, Omar. "Magnetic Resonance Molecular Imaging Using Iron Oxide Nanoparticles." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/19848.

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Magnetic resonance imaging (MRI) is regularly used to obtain anatomical images, greatly advancing biomedical research and clinical health care today, but its full potential in providing functional, physiological, and molecular information is only beginning to emerge. The goal of magnetic resonance molecular imaging is to utilize MRI to acquire information on the molecular level. This dissertation is focused on ways to increase the use of MRI for molecular imaging using superparamagnetic iron oxide (SPIO) nanoparticle induced MRI contrast. This work is divided into three main sections: <B>1)<I>

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3

Wei, Lixia. "Development of a Novel Protein Based MRI Contrast Agent for Molecular Imaging of Prostate Cancer." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_diss/75.

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Molecular Imaging provides new aspects in cancer diagnosis and treatment. With the ap-plication of imaging and biological techniques, molecular imaging can monitor molecular and cellular changes of different diseases. To interpret the mechanism of disease, more and more at-tention is focused on the development of new probes for molecular imaging. Magnetic resonance imaging (MRI) is a powerful, non-invasive clinical diagnostic tool with high spatial resolution without the limitation of the depth of tissues. Applications of MRI contrast agents can amply the MRI signal during imaging. Many studie

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4

Krishnan, Anant Subramanian. "Molecular imaging of tumour apoptosis using magnetic resonance and a targeted gadolinium-based contrast agent." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613242.

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5

Freudenberg, Robert, Rudi Apolle, Martin Walther, Holger Hartmann, and Jörg Kotzerke. "Molecular imaging using the theranostic agent 197(m)Hg: phantom measurements and Monte Carlo simulations." Springer Open, 2018. https://tud.qucosa.de/id/qucosa%3A33332.

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Background Radiomercury 197mHg and 197Hg, henceforth referred to as 197(m)Hg, is a promising theranostic radionuclide endowed with properties that allow diagnostic and therapeutic applications. The aim of this work was to investigate the capabilities of 197(m)Hg for nuclear medicine imaging. Therefore measurements were performed by using a Philips BrightView SPECT camera. Furthermore, Monte Carlo simulations using the GATE software were performed to theoretically explore the imaging contribution from the various gamma and X-ray emissions from 197(m)Hg for a commercial clinical camera with low-

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6

Qiao, Jingjuan. "Targeted Molecular MR Imaging of HER2 and EGFR Using De Novo Designed Protein Contrast Agents." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_diss/62.

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The application of magnetic resonance imaging (MRI) to non-invasively assess disease biomarkers has been hampered by lack of desired contrast agents with high relaxivity, targeting capability, and optimized pharmacokinetics. We developed a novel MRI probe which targets HER2, a biomarker for various cancers and a target for anti-cancer therapies. This multimodal HER2-targeted MRI probe integrates a rationally designed protein contrast agent with a high affinity HER2 affibody and near IR dye. Our probe can differentially monitor tumors with different HER2 levels in both cells and xenograft mice

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7

Goldsher, Anetta Victoria, and Anetta Victoria Goldsher. "Detection of Enzyme Activity in a Pancreatic Tumor Model Using CatalyCEST Contrast MRI." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625887.

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Detection of enzyme activity has gained popularity in molecular imaging because increased activity of enzymes such as urokinase plasminogen activator (uPA) can serve as biomarkers and assist in cancer diagnosis. Chemical exchange saturation transfer (CEST) Magnetic Resonance Imaging (MRI) is a non-invasive technique that can be utilized to detect enzyme activity; however, CEST MRI is not the only technique that can assess enzyme activity. Chapter 1 provides an overview of various imaging modalities that have been used to detect enzyme activity in vivo. Advances made in probe-design are discuss

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8

Miyake, Yuka. "Synthesis and Functional Evaluation of Novel Chiral Dendrimer-triamine-coordinated Gd-MRI Contrast Agents That Can Act as Molecular Probes." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215564.

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9

Liu, Guanshu. "DEVELOPMENT OF PARACEST MRI TO DETECT CANCER BIOMARKERS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1199932704.

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10

Gargam, Nicolas. "Banc microfluidique d’histologie IRM pour la modélisation in vitro du marquage moléculaire : effet du choix du marqueur et du champ magnétique sur les seuils de détection." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112118.

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Dans la foulée des avancées en médecine nucléaire, l’imagerie moléculaire par résonance magnétique a pris son essor ces dernières années car elle constitue un enjeu contemporain en vue d’améliorer le diagnostic et le suivi thérapeutique de pathologies comme le cancer ou la maladie d’Alzheimer. Cependant, cette technique d’imagerie médicale souffre à la fois de la petite quantité de récepteurs disponibles in vivo et de la faible sensibilité de l’IRM pour la détection d’agents de contraste exogènes. De ce fait, la littérature montre un intérêt croissant pour le développement de nouveaux agents d

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11

Picot, Audrey. "Develοpment οf a theranοstic agent fοr micrοthrοmbοsis during ischemic strοke". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMC418.

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De nouvelles études suggèrent que l'accident vasculaire cérébral ischémique est fréquemment associé à la formation de microthrombi dans la microcirculation corticale. Ces microthrombi sont associés à une augmentation de la taille de la lésion, à un déclin cognitif et à la démence. Il est difficile de prendre en charge ces microthrombi car les méthodes d'imagerie actuelles ne permettent pas de les détecter. Pour y remédier, un nouvel agent théranostique a été développé, les IO@PDA@tPA, combinant des microparticules d'oxyde de fer (IO) enrobées de polydopamine (PDA) et conjuguées avec l’activate

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12

Chahid, Bochra. "Développement et caractérisation de nouveaux agents de contraste lipidiques ultrasensibles pour l'imagerie par résonnance magnétique destinés à l'imagerie moléculaire." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114867/document.

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L’effet des composés paramagnétiques sur le déplacement chimique des protons, c’est-à-dire sur leur fréquence de résonance propre, beaucoup utilisé en RMN conventionnelle, peut également être un outil de contraste en Imagerie par Résonance Magnétique (IRM) pour réaliser des images encodées en fréquence et donc sélectives selon la nature ou l’environnement de l’entité que l’on cherche à révéler. Cette approche fait intervenir le transfert d’aimantation par échange chimique de protons mobiles, en anglais « Chemical Exchange Saturation Transfer » (CEST). Le principe consiste à saturer sélectiveme

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13

Moreau, Mathieu. "Marquage de molécules biologiques par des complexes de radiométaux à base de polyamines macrocycliques." Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00796881.

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Ce travail de thèse réalisé à l'Institut de Chimie Moléculaire de l'Université de Bourgogne porte dans un premier temps sur la synthèse d'agents chélatants bifonctionnels adaptés à la chélation de radiométaux trivalents, notamment l'indium-111. La plus grande partie de ce travail a ensuite consisté à réaliser le greffage d'un agent chélatant bifonctionnel dérivé du DOTA sur différents anticorps ou fragments d'anticorps monoclonaux : le trastuzumab (anti HER2, traitement de cancers du sein), le cétuximab (anti EGFR, traitement de nombreux cancers, dont le cancer colorectal) et l'abciximab (anti

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14

Oliver, Morag Helen. "Novel gadolinium agents for molecular imaging." Thesis, Imperial College London, 2005. http://hdl.handle.net/10044/1/11852.

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15

Bernhard, Claire. "Synthèse d'agents chélatants bifonctionnels macrocycliques pour le marquage de molécules biologiques par des métaux : application en imagerie médicale." Thesis, Dijon, 2011. http://www.theses.fr/2011DIJOS024/document.

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L’imagerie moléculaire est devenue incontournable pour le diagnostic et le traitement de cancers. Cette discipline regroupe un ensemble de techniques telles que la tomodensitométrie (CT), l’Imagerie par Résonance Magnétique (IRM), l’imagerie optique ou encore l’imagerie nucléaire (tomographie par émission de positons TEP, tomographie d’émission monophotonique TEMP). Chacune de ces techniques possède ses propres avantages et inconvénients et ne peut apporter à elle seule des informations anatomiques et fonctionnelles suffisantes. Les travaux actuels sont portés sur la conception de systèmes dit

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16

Waghorn, Philip A. "Investigations into porphyrins as potential molecular imaging agents." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526421.

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17

Waghorn, Philip Alan. "Investigations into porphyrins as potential molecular imaging agents." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669974.

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18

Wang, Changning. "DEVELOPMENT OF NOVEL MOLECULAR IMAGING AGENTS FOR MYELINATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1317992169.

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19

Yoo, Byunghee. "MOLECULAR IMAGING OF BREAST CANCER USING PARACEST MRI." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1183658257.

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20

Marty, Benjamin. "Développements de stratégies de quantification et de dispositifs expérimentaux pour l'IRM moléculaire de biomarqueurs endovasculaires et intratissulaires de pathologies cérébrales." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112087.

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Au cours de cette thèse, réalisée dans le cadre du projet Iseult/INUMAC, nous avons réalisé un travail de développements méthodologiques et technologiques, dans l'optique de permettre à l'IRM de devenir un outil quantitatif pour l'imagerie moléculaire de pathologies cérébrales sur des modèles rongeurs. Pour cela, nous avons développé une stratégie de quantification, utilisant des séquences de cartographie T1 et T2, pour acquérir des cartes de concentration en agents de contraste paramagnétiques et superparamagnétiques avec une excellente sensibilité, une résolution spatiale élevée, ainsi qu'un

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21

Stöckmann, Henning. "The development of new agents for molecular imaging in cancer." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610030.

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22

Talvik, Mirjam. "Clinical molecular imaging of schizophrenia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-587-5/.

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23

Kwon, Sun Kuk. "Dynamic fluorescence imaging with molecular agents for cancer detection." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1064.

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24

Fortin, Alice. "Οuverture de sultοnes par l'iοn fluοrure οu des réactifs pοlyfluοrés pοur le dévelοppement d'agents d'imagerie ΤEΡ et ΙRΜ". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMC237.

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Les travaux de cette thèse ont porté sur l’ouverture de sultones dans le cadre du développement de nouveaux agents de contraste polyfluorés amphiphiles pour l’Imagerie par Résonance Magnétique du fluor-19 (IRM du 19F). Dans une première partie, l’ouverture de sultones substituées par des nucléophiles oxygénés et azotés polyfluorés a été étudiée afin d’optimiser des conditions de synthèse d’agents de contraste dédiés à l’IRM du 19F. Dans une seconde partie, deux sultones polyfluorées ont été ouvertes par des ions [18F]fluorures, permettant d’obtenir des fluorosulfonates polyfluorés, conçus pour

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25

Stairs, Shaun Robert. "The development of new agents for molecular imaging of glycans." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648256.

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26

Williams, Jarrod C. "Design and Synthesis of Superresolution Imaging Agents." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1342887517.

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27

Hsieh, Vivian Ph D. Massachusetts Institute of Technology. "High relaxivity biomolecule based contrast agents engineered for molecular functional magnetic resonance imaging." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104206.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 71-84).<br>Magnetic resonance imaging (MRI) is a powerful neuroimaging tool that allows non-invasive visualization of the brain with high spatial and temporal resolution. Research on MRI contrast agents and their application to problems in neuroscience is burgeoning, and there is particular interest in developing MRI agents that are sensitive to time varying components of neurophysiology. Relatively recent advanc

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28

Han, Zheng. "DESIGN AND EVALUATION OF NOVEL CONTRAST AGENTS FOR MR MOLECULAR IMAGING OF CANCER." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case149139348682434.

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29

Norouzi, Neil. "Synthesis and application of novel near infrared cyanine dyes and optical imaging agents." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10002.

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The use of fluorescent imaging probes for the real time detection of cellular malfunctions, such as enzyme over expression has shown promise. Fluorescent dyes with absorption and emission values below 600 nm are limited in their in vivo applications due to high background auto-fluorescence and low resolution images. Employing near infrared (NIR) fluorophores such as cyanine dyes can overcome this disadvantage. Cyanine dyes can be synthesised using solution or solid-phase techniques with the use of solution phase chemistry allowing for larger scale and higher yielding reactions. Utilising a sel

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30

Fernández-Cuervo, Velasco Gabriela, and Velasco Gabriela Fernández-Cuervo. "Design, Synthesis and Application of catalyCEST MRI Agents for Enzyme Detection." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/626152.

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A notable need exists for noninvasive tools to increase our mechanistic understanding of disease progression at a cellular and molecular level. Studying the functions of proteins in their innate in vivo tissue environment can provide useful information about pathology enabling appropriate treatment and early diagnosis. Chemical exchange saturation transfer MRI contrast provides real-time functional characterization of the biological landscape and can be used to detect multiple enzyme biomarker activities. A dual-enzyme catalyCEST contrast agent was developed as a proof-of-concept to demonstra

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Sinharay, Sanhita. "Development and Application of CatalyCEST MRI Contrast Agents for the Study of Enzyme Activities in Tumor Models." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/612945.

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The in vivo detection of enzyme activity is a significant biomarker in tumorigenesis. Assessment of enzyme activity relative to enzyme concentration can serve as quite an accurate measurement of several disease states. Chemical Exchange Saturation Transfer (CEST) MRI is a non-invasive imaging technique that can be used to evaluate enzyme activity. Compared to other contrast agents CEST MRI agents have a slower chemical exchange rate and thus have greater specificity for detecting the intended biomarker. Chapter 1 provides an overview of the advances made in the field of molecular imaging for d

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32

Larivière, Mélusine. "Nanoparticles functionalized with human antibodies for multimodal molecular imaging of atherosclerosis." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0389/document.

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L'athérosclérose, à l’origine de la plupart des maladies cardiovasculaires telles que l'infarctus du myocarde ou l'AVC, est la principale cause de décès dans le monde. Les cliniciens ont donc besoin de techniques d'imagerie fiables pour identifier les patients «vulnérables» porteur d’athérome à haut risque d'occlusion thrombotique. Cette pathologie est une maladie inflammatoire qui implique beaucoup d'acteurs cellulaires et moléculaires, parmi lesquels les cellules endothéliales et immunitaires, les lipoprotéines, les cellules apoptotiques et les plaquettes. L'imagerie moléculaire visant à dét

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33

Arrowsmith, Rory. "Development of new bis(thiosemicarbazonates) and investigations into their potential as molecular imaging and therapeutic agents." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.642015.

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34

Daryaei, Iman, and Iman Daryaei. "Study, Evaluation, and Applications of MRI Contrast Agents that Work Based on CEST and T2-EX Mechanisms." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/625366.

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MRI is a powerful imaging method that offers several advantages including non-ionizing radiation, significant depth of penetration, and great spatial resolution. Current demand for precision medicine and the movement toward personalized medicine have encouraged researchers in the field of medical imaging to develop MRI-based techniques. Various techniques are now available for molecular imaging by MRI. MRI started by utilizing T1 relaxation properties of molecules but soon after other relaxation mechanisms such as T2 and recently Chemical Exchange Saturation Transfer (CEST) were developed. Eac

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35

Bathini, Praneeth. "EXPLOITATION OF THE IMAGE CHARACTERISTICS OF A LOCALIZED TRANSILLUMINATION SYSTEM UTILIZING MOLECULAR CONTRAST AGENTS AND POLARIMETRY." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1201198204.

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36

Akhtar, Asim. "Molecular magnetic resonance imaging of vascular inflammation using microparticles of iron oxide." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:12bf8e4f-2909-4715-a6fe-bf42d9d8355a.

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One approach that has demonstrated success in the field of molecular imaging utilizes microparticles of iron oxide (MPIO) conjugated to specific antibodies and/or peptides to provide contrast effects on MRI in relation to the molecular expression of a specified target. The experimental aims of this thesis were 1) to investigate the ability of VCAM-1 and P-selectin targeted MPIO to detect the expression of VCAM-1 and P-selectin on the activated endothelium in-vitro and in-vivo in mouse models of renal and cerebral ischemia reperfusion injury, and 2) develop a novel contrast agent for imaging αv

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37

Gebhart, Géraldine. "The contribution of molecular imaging to early evaluation of response to anti-HER2 agents in Breast Cancer." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/230875.

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L’imagerie en oncologie a fait des progrès considérables ces dernières années avec l’introduction du CT scan spiralé, de la résonance magnétique, de la mammographie digitalisée et du PET scan. Des combinaisons de différentes techniques ont vu le jour, telles que le PET/CT, et améliorent encore les possibilités de stadification de la maladie cancéreuse ainsi que le monitoring de son évolution dans le temps, et notamment sous traitement.Parallèlement, de grands progrès thérapeutiques ont étés réalisés en oncologie, en particulier le développement de médicaments « ciblés » dont l’efficacité dépen

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Tower, Robert J. [Verfasser]. "Bisphosphonates : from bone-targeted therapies to molecular imaging agents of in vivo bone metabolism / Robert J. Tower." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1155166019/34.

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Malmberg, Jennie. "Preclinical Development of Imaging Agents for HER2 Expression in Prostate Cancer Using Radiolabeled Affibody Molecules." Doctoral thesis, Uppsala universitet, Plattformen för preklinisk PET, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207256.

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This thesis is focused on pre-clinical evaluation of in vivo detection of HER2-expression in prostate cancer (PCa) patients and on the possibility of using targeted molecular imaging to personalize treatment of disseminated PCa. The work is divided into three distinct parts: (1) the establishment of a preclinical model for further studies, (2) imaging of HER2 in a murine model of PCa and (3) exploration of new treatment regimes against PCa. The characterized cell line panel reflect the heterogeneity of PCa in a way that one cell line never could, and is crucial for a better understanding of di

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Adya, Vandana. "Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1225204620.

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Shokouhimehr, Mohammadreza. "Prussian Blue Nanoparticles and its Analogues as New-Generation T1-Weighted MRI Contrast Agents for Cellular Imaging." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1275612500.

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42

Varasteh, Zohreh. "Bombesin Antagonists for Targeting Gastrin-Releasing Peptide Receptor-Positive Tumors : Design, Synthesis, Preclinical Evaluation and Optimization of Imaging Agents." Doctoral thesis, Uppsala universitet, Plattformen för preklinisk PET, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-232123.

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This thesis is focused on the development, preclinical evaluation, and optimization of radiotracers for the detection of gastrin-releasing peptide receptor (GRPR)-expressing tumors. The work is divided into three distinct parts: (1) the development of bombesin (BN) antagonist (RM26)-based imaging radiotracers for the detection of GRPR-expressing tumors using different positron emission tomography (PET) and single photon emission computed tomography (SPECT) radionuclides (68Ga, 18F and 111In), (2) the establishment of a method to monitor the ligand-G protein-coupled receptor (GPCR) interaction

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Godavarty, Anuradha. "Fluorescence enhanced optical tomography on breast phantoms with measurements using a gain modulated intensified CCD imaging system." Texas A&M University, 2003. http://hdl.handle.net/1969.1/2184.

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Fluorescence-enhanced optical imaging using near-infrared (NIR) light developed for in-vivo molecular targeting and reporting of cancer provides promising opportunities for diagnostic imaging. However, prior to the administration of unproven contrast agents, the benefits of fluorescence-enhanced optical imaging must be assessed in feasibility phantom studies. A novel intensified charge-coupled device (ICCD) imaging system has been developed to perform 3-D fluorescence tomographic imaging in the frequency-domain using near-infrared contrast agents. This study is unique since it (i) employs

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44

Topley, Amy Clare. "The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/167749/.

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A range of resin bound sulfonate ester linkers were developed for use in the resin-linker-vector (RLV) approach for the synthesis of [18F]-fluoride radiotracers for use as imaging agents in positron-emission-tomography (PET). The RLV strategy immobilises a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the 18F-labelled radiotracer in solution. The RLV methodology allows for easier purification of the 18F-labelled radiotracer as a simple filtration step removes the unreacted starting material and the cleaved resin. Synthetic ro

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Harris, Steven Scott. "Adiabatic pulse preparation for imaging iron oxide nanoparticles." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/47555.

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Iron oxide nanoparticles are of great interest as contrast agents for research and potentially clinical molecular magnetic resonance imaging (MRI). Biochemically modifying the surface coatings of the particles with proteins and polysaccharides enhances their utility by improving cell receptor specificity, increasing uptake for cell labeling and adding therapeutic molecules. Together with the high contrast they produce in MR images, these characteristics promise an expanding role for iron oxide nanoparticles and molecular MR imaging for studying, diagnosing and treating diseases at the molecula

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Thörn, Seshold Oliver. "Development of Auto-Immolative Spacers for Probes of Enzyme Activity." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2013. http://tel.archives-ouvertes.fr/tel-00998379.

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This thesis concerns the design and implementation of novel auto-immolative spacers for use in probes for enzymatic activity in vivo.The first part relates the development and in vitro validation of cyclisation spacers which couple the action of an aminopeptidase to the release of a phenol. The modular three-component fluorogenic probes based on these 1,2-diamine spacers are very robust (halflife > 560 h), but are also rapidly enzymatically processed, and quickly (halftime ~3 min) release an exceptionally photostable, insoluble ESIPT fluorophore. The probes have excellent detection sensitivity

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Anastos, Thèo. "Studying the Efficacy of an Injectable 3-Dimensional Fibrin Extracellular Matrix to Characterize the Effects of Antitumor Agents on SW620 Cells in A Microfluidic Device." DigitalCommons@CalPoly, 2021. https://digitalcommons.calpoly.edu/theses/2277.

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Colorectal cancer is the third most common cancer in the United States and there is currently a lot of research going into new antitumor agents to kill the cancer. One method for replicating the tumor response to a drug in vivo is by creating an in vitro drug testing model to replicate the in vivo condition. This research project was conducted to determine the efficacy of testing tumor cultures in a microfluidic device as a way to provide accurate drug responses in vitro instead of using in vivo subjects in clinical trials. A total of four experiments were conducted with each experiment increa

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Pauff, Steven M. "Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/751.

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Fluorescence-based imaging techniques provide a simple, highly sensitive method of studying live cells and whole organisms in real time. Without question, fluorophores such as GFP, fluorescein, and rhodamines have contributed vastly to our understanding of both cell biology and biochemistry. However, most of the fluorescent molecules currently utilized suffer from one major drawback, the use of visible light. Due to cellular autofluorescence and the absorbance of incident light by cellular components, fluorescence imaging with visible wavelength fluorophores often results in high background no

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Pauff, Steven M. "Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/751.

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Abstract:

Fluorescence-based imaging techniques provide a simple, highly sensitive method of studying live cells and whole organisms in real time. Without question, fluorophores such as GFP, fluorescein, and rhodamines have contributed vastly to our understanding of both cell biology and biochemistry. However, most of the fluorescent molecules currently utilized suffer from one major drawback, the use of visible light. Due to cellular autofluorescence and the absorbance of incident light by cellular components, fluorescence imaging with visible wavelength fluorophores often results in high background no

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Kolanowski, Jacek Lukasz. "Bispidine-iron (II) complexes as a novel platform for the design of magentogenic probes." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2013. http://tel.archives-ouvertes.fr/tel-01059820.

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This work concerns the development and characterization of molecular probes that respond to a chemical analyte in a liquid sample by turning from a diamagnetic to a paramagnetic state (off-on mode).With the aim of designing these tools, we focused on iron(II) chelates of bicyclic bispidines as they promised, among others, sufficient probe stability, even in competitive media like water. This manuscript describes new robust synthetic protocols for their large-scale preparation. Synthesized bispidine-iron(II) complexes were thoroughly characterized in solution (1D/2D NMR, MS, UV-Vis, CV) and in

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