Academic literature on the topic 'Molecular Imaging (MI)'

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Journal articles on the topic "Molecular Imaging (MI)"

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Streeter, Jason E., Ryan C. Gessner, James Tsuruta, Steven Feingold, and Paul A. Dayton. "Assessment of Molecular Imaging of Angiogenesis with Three-Dimensional Ultrasonography." Molecular Imaging 10, no. 6 (2011): 7290.2011.00015. http://dx.doi.org/10.2310/7290.2011.00015.

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Molecular imaging (MI) with ultrasonography relies on microbubble contrast agents (MCAs) adhering to a ligand-specific target for applications such as characterizing tumor angiogenesis. It is projected that ultrasonic (US) MI can provide information about tumor therapeutic response before the detection of phenotypic changes. One of the limitations of preclinical US MI is that it lacks a comprehensive field of view. We attempted to improve targeted MCA visualization and quantification by performing three-dimensional (3D) MI of tumors expressing αvβ3 integrin. Volumetric acquisitions were obtain
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Ali, Yadollahpour, Rezaee Zohre, Jalilifar Mostafa, and Rashidi Samaneh. "Dye-Doped Fluorescent Nanoparticles in Molecular Imaging: A Review of Recent Advances and Future Opportunities." Material Science Research India 11, no. 2 (2014): 102–13. http://dx.doi.org/10.13005/msri/110203.

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Molecular imaging (MI) is an in vivo assessment of characterization and quantitatively measurement of biological processes at the molecular level. Determination of pathologies of malfunctioned tissues without invasive biopsies or surgical procedures, early detection, monitoring of treatment process and visualization of cell trafficking are advantages of this approach. One example of basic requirement of MI is high affinity molecular probe that acts as the source of image contrast. Recent advances in nanotechnology have developed the use of nanoparticles as MI probe. Optical molecular imaging i
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Woźniak, Marcin, Agata Płoska, Anna Siekierzycka, Lawrence W. Dobrucki, Leszek Kalinowski, and Iwona T. Dobrucki. "Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy." International Journal of Molecular Sciences 23, no. 5 (2022): 2658. http://dx.doi.org/10.3390/ijms23052658.

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Personalized medicine is emerging as a new goal in the diagnosis and treatment of diseases. This approach aims to establish differences between patients suffering from the same disease, which allows to choose the most effective treatment. Molecular imaging (MI) enables advanced insight into molecule interactions and disease pathology, improving the process of diagnosis and therapy and, for that reason, plays a crucial role in personalized medicine. Nanoparticles are widely used in MI techniques due to their size, high surface area to volume ratio, and multifunctional properties. After conjugat
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Anderson, Carolyn J., and Jason S. Lewis. "Current status and future challenges for molecular imaging." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 375, no. 2107 (2017): 20170023. http://dx.doi.org/10.1098/rsta.2017.0023.

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Molecular imaging (MI), used in its wider sense of biology at the molecular level, is a field that lies at the intersection of molecular biology and traditional medical imaging. As advances in medicine have exponentially expanded over the last few decades, so has our need to better understand the fundamental behaviour of living organisms in a non-invasive and timely manner. This commentary draws from topics the authors addressed in their presentations at the 2017 Royal Society Meeting ‘Challenges for chemistry in molecular imaging’, as well as a discussion of where MI is today and where it is
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Jin, Ke-Tao, Jia-Yu Yao, Xiao-Jiang Ying, Yan Lin, and Yun-Fang Chen. "Nanomedicine and Early Cancer Diagnosis: Molecular Imaging using Fluorescence Nanoparticles." Current Topics in Medicinal Chemistry 20, no. 30 (2020): 2737–61. http://dx.doi.org/10.2174/1568026620666200922112640.

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Incorporating nanotechnology into fluorescent imaging and magnetic resonance imaging (MRI) has shown promising potential for accurate diagnosis of cancer at an earlier stage than the conventional imaging modalities. Molecular imaging (MI) aims to quantitatively characterize, visualize, and measure the biological processes or living cells at molecular and genetic levels. MI modalities have been exploited in different applications including noninvasive determination and visualization of diseased tissues, cell trafficking visualization, early detection, treatment response monitoring, and in vivo
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Hess, Annika, Thorsten Derlin, Tobias Koenig, et al. "Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4." European Heart Journal 41, no. 37 (2020): 3564–75. http://dx.doi.org/10.1093/eurheartj/ehaa598.

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Abstract Aims Balance between inflammatory and reparative leucocytes allows optimal healing after myocardial infarction (MI). Interindividual heterogeneity evokes variable functional outcome complicating targeted therapy. We aimed to characterize infarct chemokine CXC-motif receptor 4 (CXCR4) expression using positron emission tomography (PET) and establish its relationship to cardiac outcome. We tested whether image-guided early CXCR4 directed therapy attenuates chronic dysfunction. Methods and results Mice (n = 180) underwent coronary ligation or sham surgery and serial PET imaging over 7 da
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Weissenböck, Victoria, Lukas Weber, Michaela Schlederer, et al. "Molecular Imaging of Fibroblast Activation Protein in Response to Cardiac Injury Using [68Ga]Ga-DATA5m.SA.FAPi." Pharmaceuticals 18, no. 5 (2025): 658. https://doi.org/10.3390/ph18050658.

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Background/Objectives: Fibroblast activation protein (FAP) has gained tremendous traction as a target for tumor imaging and cancer treatment, while also playing a key role in fibrosis. Our study aimed to evaluate [68Ga]Ga-DATA5m.SA.FAPi for PET imaging of replacement fibrosis following myocardial infarction (MI) or interstitial fibrosis associated with hypertrophy. Methods: MI or transverse aortic constriction (TAC)-induced hypertrophy was induced in C57BL/6 mice, with sham-operated animals serving as controls. At multiple time points during disease progression (1, 2, and 6 weeks post-surgery)
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Güzel, Özer, Fazlı Polat, and Ali Atan. "Is it time to stage prostate cancer using molecular imaging?" Yeni Üroloji Dergisi 17, no. 2 (2022): 109–15. http://dx.doi.org/10.33719/yud.2022;17-2-1035767.

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Prostate cancer is one of the most common cancers in men. After the diagnosis is made, staging should be undertaken with imaging methods in order to plan the treatment and predict the prognosis. Parallel to technological developments in recent years, new imaging methods have entered into clinical use. Among these methods, prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging has come to the fore since it provides anatomical and functional imaging and has many advantages in tumor (T), nodal (N) and metastatic (M) staging. This review discusses the current status o
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Moyon, Anaïs, Philippe Garrigue, Samantha Fernandez, et al. "Comparison of a New 68Ga-Radiolabelled PET Imaging Agent sCD146 and RGD Peptide for In Vivo Evaluation of Angiogenesis in Mouse Model of Myocardial Infarction." Cells 10, no. 9 (2021): 2305. http://dx.doi.org/10.3390/cells10092305.

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Ischemic vascular diseases are associated with elevated tissue expression of angiomotin (AMOT), a promising molecular target for PET imaging. On that basis, we developed an AMOT-targeting radiotracer, 68Ga-sCD146 and performed the first in vivo evaluation on a myocardial infarction mice model and then, compared AMOT expression and αvβ3-integrin expression with 68Ga-sCD146 and 68Ga-RGD2 imaging. After myocardial infarction (MI) induced by permanent ligation of the left anterior descending coronary artery, myocardial perfusion was evaluated by Doppler ultrasound and by 18F-FDG PET imaging. 68Ga-
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Knot, H. J. "Twenty Years of Calcium Imaging: Cell Physiology to Dye For." Molecular Interventions 5, no. 2 (2005): 112–27. http://dx.doi.org/10.1124/mi.5.2.8.

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Book chapters on the topic "Molecular Imaging (MI)"

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Sołtysiński, Tomasz. "Advanced Approaches to Diagnose and Treat the Chronic Autoimmune Disorders." In Medical Imaging. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-0571-6.ch073.

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Pathology and dynamics of particular cells and the molecular components of immune system is still challenging to be traced within living organisms. The techniques of molecular imaging (MI) are promising tools to monitor the immune system at work, to improve or allow personalized diagnostics and treatment, especially of the autoimmune diseases. In this study some possible targets for MI and biosensing are discussed. The personalized medicine, in addition to bioinformatics-based systemic approach, requires extensive research and novel high-throughput technologies like next generation of imaging,
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Sołtysiński, Tomasz. "Advanced Approaches to Diagnose and Treat the Chronic Autoimmune Disorders." In Handbook of Research on Trends in the Diagnosis and Treatment of Chronic Conditions. IGI Global, 2016. http://dx.doi.org/10.4018/978-1-4666-8828-5.ch004.

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Pathology and dynamics of particular cells and the molecular components of immune system is still challenging to be traced within living organisms. The techniques of molecular imaging (MI) are promising tools to monitor the immune system at work, to improve or allow personalized diagnostics and treatment, especially of the autoimmune diseases. In this study some possible targets for MI and biosensing are discussed. The personalized medicine, in addition to bioinformatics-based systemic approach, requires extensive research and novel high-throughput technologies like next generation of imaging,
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