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Journal articles on the topic 'Molecular Imaging (MI)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Streeter, Jason E., Ryan C. Gessner, James Tsuruta, Steven Feingold, and Paul A. Dayton. "Assessment of Molecular Imaging of Angiogenesis with Three-Dimensional Ultrasonography." Molecular Imaging 10, no. 6 (2011): 7290.2011.00015. http://dx.doi.org/10.2310/7290.2011.00015.

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Molecular imaging (MI) with ultrasonography relies on microbubble contrast agents (MCAs) adhering to a ligand-specific target for applications such as characterizing tumor angiogenesis. It is projected that ultrasonic (US) MI can provide information about tumor therapeutic response before the detection of phenotypic changes. One of the limitations of preclinical US MI is that it lacks a comprehensive field of view. We attempted to improve targeted MCA visualization and quantification by performing three-dimensional (3D) MI of tumors expressing αvβ3 integrin. Volumetric acquisitions were obtain

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Ali, Yadollahpour, Rezaee Zohre, Jalilifar Mostafa, and Rashidi Samaneh. "Dye-Doped Fluorescent Nanoparticles in Molecular Imaging: A Review of Recent Advances and Future Opportunities." Material Science Research India 11, no. 2 (2014): 102–13. http://dx.doi.org/10.13005/msri/110203.

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Molecular imaging (MI) is an in vivo assessment of characterization and quantitatively measurement of biological processes at the molecular level. Determination of pathologies of malfunctioned tissues without invasive biopsies or surgical procedures, early detection, monitoring of treatment process and visualization of cell trafficking are advantages of this approach. One example of basic requirement of MI is high affinity molecular probe that acts as the source of image contrast. Recent advances in nanotechnology have developed the use of nanoparticles as MI probe. Optical molecular imaging i

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Woźniak, Marcin, Agata Płoska, Anna Siekierzycka, Lawrence W. Dobrucki, Leszek Kalinowski, and Iwona T. Dobrucki. "Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy." International Journal of Molecular Sciences 23, no. 5 (2022): 2658. http://dx.doi.org/10.3390/ijms23052658.

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Personalized medicine is emerging as a new goal in the diagnosis and treatment of diseases. This approach aims to establish differences between patients suffering from the same disease, which allows to choose the most effective treatment. Molecular imaging (MI) enables advanced insight into molecule interactions and disease pathology, improving the process of diagnosis and therapy and, for that reason, plays a crucial role in personalized medicine. Nanoparticles are widely used in MI techniques due to their size, high surface area to volume ratio, and multifunctional properties. After conjugat

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Anderson, Carolyn J., and Jason S. Lewis. "Current status and future challenges for molecular imaging." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 375, no. 2107 (2017): 20170023. http://dx.doi.org/10.1098/rsta.2017.0023.

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Molecular imaging (MI), used in its wider sense of biology at the molecular level, is a field that lies at the intersection of molecular biology and traditional medical imaging. As advances in medicine have exponentially expanded over the last few decades, so has our need to better understand the fundamental behaviour of living organisms in a non-invasive and timely manner. This commentary draws from topics the authors addressed in their presentations at the 2017 Royal Society Meeting ‘Challenges for chemistry in molecular imaging’, as well as a discussion of where MI is today and where it is

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Jin, Ke-Tao, Jia-Yu Yao, Xiao-Jiang Ying, Yan Lin, and Yun-Fang Chen. "Nanomedicine and Early Cancer Diagnosis: Molecular Imaging using Fluorescence Nanoparticles." Current Topics in Medicinal Chemistry 20, no. 30 (2020): 2737–61. http://dx.doi.org/10.2174/1568026620666200922112640.

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Incorporating nanotechnology into fluorescent imaging and magnetic resonance imaging (MRI) has shown promising potential for accurate diagnosis of cancer at an earlier stage than the conventional imaging modalities. Molecular imaging (MI) aims to quantitatively characterize, visualize, and measure the biological processes or living cells at molecular and genetic levels. MI modalities have been exploited in different applications including noninvasive determination and visualization of diseased tissues, cell trafficking visualization, early detection, treatment response monitoring, and in vivo

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Hess, Annika, Thorsten Derlin, Tobias Koenig, et al. "Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4." European Heart Journal 41, no. 37 (2020): 3564–75. http://dx.doi.org/10.1093/eurheartj/ehaa598.

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Abstract Aims Balance between inflammatory and reparative leucocytes allows optimal healing after myocardial infarction (MI). Interindividual heterogeneity evokes variable functional outcome complicating targeted therapy. We aimed to characterize infarct chemokine CXC-motif receptor 4 (CXCR4) expression using positron emission tomography (PET) and establish its relationship to cardiac outcome. We tested whether image-guided early CXCR4 directed therapy attenuates chronic dysfunction. Methods and results Mice (n = 180) underwent coronary ligation or sham surgery and serial PET imaging over 7 da

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Weissenböck, Victoria, Lukas Weber, Michaela Schlederer, et al. "Molecular Imaging of Fibroblast Activation Protein in Response to Cardiac Injury Using [68Ga]Ga-DATA5m.SA.FAPi." Pharmaceuticals 18, no. 5 (2025): 658. https://doi.org/10.3390/ph18050658.

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Background/Objectives: Fibroblast activation protein (FAP) has gained tremendous traction as a target for tumor imaging and cancer treatment, while also playing a key role in fibrosis. Our study aimed to evaluate [68Ga]Ga-DATA5m.SA.FAPi for PET imaging of replacement fibrosis following myocardial infarction (MI) or interstitial fibrosis associated with hypertrophy. Methods: MI or transverse aortic constriction (TAC)-induced hypertrophy was induced in C57BL/6 mice, with sham-operated animals serving as controls. At multiple time points during disease progression (1, 2, and 6 weeks post-surgery)

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Güzel, Özer, Fazlı Polat, and Ali Atan. "Is it time to stage prostate cancer using molecular imaging?" Yeni Üroloji Dergisi 17, no. 2 (2022): 109–15. http://dx.doi.org/10.33719/yud.2022;17-2-1035767.

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Prostate cancer is one of the most common cancers in men. After the diagnosis is made, staging should be undertaken with imaging methods in order to plan the treatment and predict the prognosis. Parallel to technological developments in recent years, new imaging methods have entered into clinical use. Among these methods, prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging has come to the fore since it provides anatomical and functional imaging and has many advantages in tumor (T), nodal (N) and metastatic (M) staging. This review discusses the current status o

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Moyon, Anaïs, Philippe Garrigue, Samantha Fernandez, et al. "Comparison of a New 68Ga-Radiolabelled PET Imaging Agent sCD146 and RGD Peptide for In Vivo Evaluation of Angiogenesis in Mouse Model of Myocardial Infarction." Cells 10, no. 9 (2021): 2305. http://dx.doi.org/10.3390/cells10092305.

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Ischemic vascular diseases are associated with elevated tissue expression of angiomotin (AMOT), a promising molecular target for PET imaging. On that basis, we developed an AMOT-targeting radiotracer, 68Ga-sCD146 and performed the first in vivo evaluation on a myocardial infarction mice model and then, compared AMOT expression and αvβ3-integrin expression with 68Ga-sCD146 and 68Ga-RGD2 imaging. After myocardial infarction (MI) induced by permanent ligation of the left anterior descending coronary artery, myocardial perfusion was evaluated by Doppler ultrasound and by 18F-FDG PET imaging. 68Ga-

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Knot, H. J. "Twenty Years of Calcium Imaging: Cell Physiology to Dye For." Molecular Interventions 5, no. 2 (2005): 112–27. http://dx.doi.org/10.1124/mi.5.2.8.

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Sharma, Yash Paul, Krishna Prasad, Nitin Patel, and Prashant Kumar Panda. "Acute myocardial infarction in a young patient with triple valve replacement." BMJ Case Reports 14, no. 7 (2021): e240732. http://dx.doi.org/10.1136/bcr-2020-240732.

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Rheumatic heart disease is an important cause of mortality and morbidity in developing countries, and is the leading cause of triple valve replacement. Myocardial infarction (MI) in such cases can be due to the coronary embolism from the prosthetic valves or due to atherosclerotic vascular disease. Intravascular imaging helps in delineating the cause. We present a case of a 34-year-old premenopausal woman with no conventional cardiovascular risk factors and had triple valve replacement 4 years ago and anterior wall MI with cardiogenic shock and left ventricular failure. She was managed with me

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Werner, Rudolf A., James T. Thackeray, Martin G. Pomper, et al. "Recent Updates on Molecular Imaging Reporting and Data Systems (MI-RADS) for Theranostic Radiotracers—Navigating Pitfalls of SSTR- and PSMA-Targeted PET/CT." Journal of Clinical Medicine 8, no. 7 (2019): 1060. http://dx.doi.org/10.3390/jcm8071060.

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The theranostic concept represents a paradigmatic example of personalized treatment. It is based on the use of radiolabeled compounds which can be applied for both diagnostic molecular imaging and subsequent treatment, using different radionuclides for labelling. Clinically relevant examples include somatostatin receptor (SSTR)-targeted imaging and therapy for the treatment of neuroendocrine tumors (NET), as well as prostate-specific membrane antigen (PSMA)-targeted imaging and therapy for the treatment of prostate cancer (PC). As such, both classes of radiotracers can be used to triage patien

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Gupta, Manoj, Ankush Jajodia, Parveen Ahlawat, et al. "Effectiveness of Head-and-Neck Molecular Imaging Reporting and Data System Criterion in Head-and-Neck Squamous Cell Carcinoma PostConcurrent Chemoradiotherapy." Indian Journal of Nuclear Medicine 38, no. 4 (2023): 334–39. http://dx.doi.org/10.4103/ijnm.ijnm_23_23.

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Purpose: Postconcurrent chemoradiotherapy (CRT) response assessment has been challenging in locally advanced head-and-neck squamous cell carcinoma (LA-HNSCC) due to prevailing postradiation changes. Molecular response methods have been encouraging, although further clarifications and validations were needed. We tested the effectiveness of a proposed semi-quantitative molecular response criterion in these patients. Materials and Methods: Two subspecialty-trained physicians evaluated 18F-fluorodeoxyglucose positron emission tomography/computed tomography of LA-HNSCC patients (n = 83) post 3 mont

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Tremblay, Samuel, Mofarej Alhogbani, Andrew Weickhardt, et al. "Influence of molecular imaging on patient selection for treatment intensification prior to salvage radiation therapy for prostate cancer: A post hoc analysis of the PROPS trial." Journal of Clinical Oncology 41, no. 6_suppl (2023): 316. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.316.

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316 Background: The impact of molecular imaging (MI) on patient management after biochemical recurrence (BCR) following radical prostatectomy has been described in many studies. However, it is not known if MI-induced management changes are appropriate. This study aimed to determine if androgen deprivation therapy (ADT) management plan is improved by MI in patients who are candidates for salvage radiation therapy. Methods: Data were analyzed from the multicenter prospective PROPS trial evaluating PSMA/Choline PET in patients being considered for salvage radiotherapy (sRT) with BCR after prostat

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Rowe, Steven P. "Artificial intelligence in molecular imaging: at the crossroads of revolutions in medical diagnosis." Annals of Translational Medicine 9, no. 9 (2021): 817. http://dx.doi.org/10.21037/atm-2020-mi-09.

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Tam, Jenny, Alexander Pilozzi, Umar Mahmood, and Xudong Huang. "Simultaneous Monitoring of Multi-Enzyme Activity and Concentration in Tumor Using a Triply Labeled Fluorescent In Vivo Imaging Probe." International Journal of Molecular Sciences 21, no. 9 (2020): 3068. http://dx.doi.org/10.3390/ijms21093068.

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The use of fluorescent imaging probes that monitor the activity of proteases that experience an increase in expression and activity in tumors is well established. These probes can be conjugated to nanoparticles of iron oxide, creating a multimodal probe serving as both a magnetic resonance imaging (MRI) agent and an indicator of local protease activity. Previous works describe probes for cathepsin D (CatD) and metalloproteinase-2 (MMP2) protease activity grafted to cross-linked iron oxide nanoparticles (CLIO). Herein, we have synthesized a triply labeled fluorescent iron oxide nanoparticle mol

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Kolanowski, Tomasz Jan, Weronika Wargocka-Matuszewska, Agnieszka Zimna, et al. "Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([18F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers." International Journal of Molecular Sciences 22, no. 22 (2021): 12591. http://dx.doi.org/10.3390/ijms222212591.

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Cardiovascular diseases (CVD), with myocardial infarction (MI) being one of the crucial components, wreak havoc in developed countries. Advanced imaging technologies are required to obtain quick and widely available diagnostic data. This paper describes a multimodal approach to in vivo perfusion imaging using the novel SYN1 tracer based on the fluorine-18 isotope. The NOD-SCID mice were injected intravenously with SYN1 or [18F] fluorodeoxyglucose ([18F]-FDG) radiotracers after induction of the MI. In all studies, the positron emission tomography–computed tomography (PET/CT) technique was used.

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Shrivastava, Apurva, Vincenzo Marzolla, Henri Weidmann, et al. "Design and Rationale of the ERA-CVD Consortium PREMED-CAD—Precision Medicine in Coronary Artery Disease." Biomolecules 10, no. 1 (2020): 125. http://dx.doi.org/10.3390/biom10010125.

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Cardiovascular diseases (CVDs) comprise 45% of all deaths in Europe and causes 3.9 million deaths annually. Coronary artery disease (CAD) which includes myocardial infarction (MI) represents the most common form of CVD. A relevant proportion of MI cases seems preventable since reports claim that up to two-thirds of these patients exhibit symptoms suggestive for MI within 12 months prior to the acute MI event. An early identification of these at-risk subjects is necessary to manage an early and efficient treatment during the ischemic phase. The aim of the PRecision MEDicine in Coronary Artery D

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Zeller, Matthias W. G., Cuihua Wang, Edmund J. Keliher, et al. "Myeloperoxidase PET Imaging Tracks Intracellular and Extracellular Treatment Changes in Experimental Myocardial Infarction." International Journal of Molecular Sciences 24, no. 6 (2023): 5704. http://dx.doi.org/10.3390/ijms24065704.

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Myeloperoxidase (MPO) is a highly oxidative, pro-inflammatory enzyme involved in post-myocardial infarction (MI) injury and is a potential therapeutic target. While multiple MPO inhibitors have been developed, the lack of an imaging reporter to select appropriate patients and assess therapeutic efficacy has hampered clinical development. Thus, a translational imaging method to detect MPO activity non-invasively would help to better understand the role MPO plays in MI and facilitate novel therapy development and clinical validation. Interestingly, many MPO inhibitors affect both intracellular a

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Yasui, Hiroshi, Kenji Hirano, Kiyosumi Ochi, et al. "Immune Function of Chimeric Antigen Receptor T Cells Quantitatively Assessed Via Molecular Imaging Flow Cytometry." Blood 142, Supplement 1 (2023): 6821. http://dx.doi.org/10.1182/blood-2023-173065.

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Chimeric antigen receptor (CAR) T cells are an adoptive cell immunotherapy genetically synthesized to reprogram T cells for antigen recognition and intracellular signaling to target tumor cells for destruction. A sensitive and reproducible assay to evaluate CAR T cell function is essential to research and develop novel therapies, optimize manufacturing, and evaluate efficacy in the clinical and non-clinical settings. However, conventional methods, such as cytotoxicity assays and in vitro cytokine production, require a long cell culture processing time with a less quantitative and more time-con

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Satrya, Gandeva Bayu, I. Nyoman Apraz Ramatryana, and Soo Young Shin. "Compressive Sensing of Medical Images Based on HSV Color Space." Sensors 23, no. 5 (2023): 2616. http://dx.doi.org/10.3390/s23052616.

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Recently, compressive sensing (CS) schemes have been studied as a new compression modality that exploits the sensing matrix in the measurement scheme and the reconstruction scheme to recover the compressed signal. In addition, CS is exploited in medical imaging (MI) to support efficient sampling, compression, transmission, and storage of a large amount of MI. Although CS of MI has been extensively investigated, the effect of color space in CS of MI has not yet been studied in the literature. To fulfill these requirements, this article proposes a novel CS of MI based on hue-saturation value (HS

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Stefano Filho, Carlos Alberto, Romis Attux, and Gabriela Castellano. "Motor imagery practice and feedback effects on functional connectivity." Journal of Neural Engineering 18, no. 6 (2021): 066048. http://dx.doi.org/10.1088/1741-2552/ac456d.

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Abstract Objective. The use of motor imagery (MI) in motor rehabilitation protocols has been increasingly investigated as a potential technique for enhancing traditional treatments, yielding better clinical outcomes. However, since MI performance can be challenging, practice is usually required. This demands appropriate training, actively engaging the MI-related brain areas, consequently enabling the user to properly benefit from it. The role of feedback is central for MI practice. Yet, assessing which underlying neural changes are feedback-specific or purely due to MI practice is still a chal

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Luengo Morato, Yurena, Karina Ovejero Paredes, Laura Lozano Chamizo, Marzia Marciello, and Marco Filice. "Recent Advances in Multimodal Molecular Imaging of Cancer Mediated by Hybrid Magnetic Nanoparticles." Polymers 13, no. 17 (2021): 2989. http://dx.doi.org/10.3390/polym13172989.

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Cancer is the second leading cause of death in the world, which is why it is so important to make an early and very precise diagnosis to obtain a good prognosis. Thanks to the combination of several imaging modalities in the form of the multimodal molecular imaging (MI) strategy, a great advance has been made in early diagnosis, in more targeted and personalized therapy, and in the prediction of the results that will be obtained once the anticancer treatment is applied. In this context, magnetic nanoparticles have been positioned as strong candidates for diagnostic agents as they provide very

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Ahlswede, Mareike, Patrick Nösel, Andrew A. Maudsley, et al. "Alterations of Striato-Thalamic Metabolism in Normal Aging Human Brain—An MR Metabolic Imaging Study." Metabolites 11, no. 6 (2021): 371. http://dx.doi.org/10.3390/metabo11060371.

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Aging effects on striato-thalamic metabolism in healthy human brains were studied in vivo using short-TE whole brain 1H-MR spectroscopic imaging (wbMRSI) on eighty healthy subjects aged evenly between 20 to 70 years at 3T. Relative concentrations of N-acetyl-aspartate (NAA), choline, total creatine (tCr), myo-inositol (mI), glutamate, and glutamine in bilateral caudate nucleus, putamen, pallidum, and thalamus were determined using signal normalization relative to brain tissue water. Linear regression analysis was used to analyze the age-dependence of the metabolite concentrations. The metaboli

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Zhang, Zhihao, Qin Fang, Tingyi Du, Guangzhi Chen, Yan Wang, and Dao Wen Wang. "Cardiac-Specific Caveolin-3 Overexpression Prevents Post-Myocardial Infarction Ventricular Arrhythmias by Inhibiting Ryanodine Receptor-2 Hyperphosphorylation." Cardiology 145, no. 3 (2020): 136–47. http://dx.doi.org/10.1159/000505316.

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Introduction: Ventricular arrhythmia is the most important risk factor for sudden cardiac death (SCD) after acute myocardial infarction (MI) worldwide. However, the molecular mechanisms underlying these arrhythmias are complex and not completely understood. Objective: Here, we evaluated whether caveolin-3 (Cav3), the structural protein of caveolae, plays an important role in the therapeutic strategy for ventricular arrhythmias. Methods: A model of cardiac-specific overexpression of Cav3 was established to evaluate the incidence of ventricular arrhythmias after MI in mice. Ca2+ imaging was empl

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Hernandez-Resendiz, Sauri, Kroekkiat Chinda, Sang-Bing Ong, Hector Cabrera-Fuentes, Cecilia Zazueta, and Derek j. Hausenloy. "The Role of Redox Dysregulation in the Inflammatory Response to Acute Myocardial Ischaemia-reperfusion Injury - Adding Fuel to the Fire." Current Medicinal Chemistry 25, no. 11 (2018): 1275–93. http://dx.doi.org/10.2174/0929867324666170329100619.

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Background: The inflammatory response to acute myocardial ischaemia/ reperfusion injury (IRI) plays a critical role in determining myocardial infarct (MI) size, and subsequent post-MI left ventricular (LV) remodelling, making it a potential therapeutic target for improving clinical outcomes in patients presenting with an acute myocardial infarction (AMI). Recent experimental studies using advanced imaging and molecular techniques, have yielded new insights into the mechanisms through which reactive oxygen species (ROS) contribute to the inflammatory response induced by acute myocardial IRI - “

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Ladd, L. A., K. D. Tinworth, D. L. Bailey, et al. "SPECT/CT imaging for tracking myocardial infarction (MI) in an ovine model." Journal of Molecular and Cellular Cardiology 41, no. 4 (2006): 739. http://dx.doi.org/10.1016/j.yjmcc.2006.06.032.

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Li, Xinnan, Kagari Abiko, Sulaiman Sheriff, et al. "The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings." Metabolites 12, no. 6 (2022): 543. http://dx.doi.org/10.3390/metabo12060543.

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This prospective study aimed to evaluate the variation in magnetic resonance spectroscopic imaging (MRSI)-observed brain metabolite concentrations according to anatomical location, sex, and age, and the relationships among regional metabolite distributions, using short echo time (TE) whole-brain MRSI (WB-MRSI). Thirty-eight healthy participants underwent short TE WB-MRSI. The major metabolite ratios, i.e., N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr, glutamate + glutamine (Glx)/Cr, and myoinositol (mI)/Cr, were calculated voxel-by-voxel. Their variations according to anatomical re

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Guo, Dan, Melanie Christine Föll, Veronika Volkmann, et al. "Deep multiple instance learning classifies subtissue locations in mass spectrometry images from tissue-level annotations." Bioinformatics 36, Supplement_1 (2020): i300—i308. http://dx.doi.org/10.1093/bioinformatics/btaa436.

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Abstract Motivation Mass spectrometry imaging (MSI) characterizes the molecular composition of tissues at spatial resolution, and has a strong potential for distinguishing tissue types, or disease states. This can be achieved by supervised classification, which takes as input MSI spectra, and assigns class labels to subtissue locations. Unfortunately, developing such classifiers is hindered by the limited availability of training sets with subtissue labels as the ground truth. Subtissue labeling is prohibitively expensive, and only rough annotations of the entire tissues are typically availabl

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Long, Li-Ling, Xiang-Rong Li, Zhong-Kui Huang, Yue-Ming Jiang, Sherleen X. Fu, and Wei Zheng. "Relationship Between Changes in Brain MRI and 1H-MRS, Severity of Chronic Liver Damage, and Recovery After Liver Transplantation." Experimental Biology and Medicine 234, no. 9 (2009): 1075–85. http://dx.doi.org/10.3181/0903-rm-118.

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Magnetic resonance imaging (MRI) and 1H magnetic resonance spectroscopy (1H-MRS) have been used in clinics for diagnosis of chronic liver diseases. This study was designed to investigate the relationship between MRI/MRS outcomes and the severity of liver damage. Of 50 patients examined, the MRI signal intensity in the globus pallidus as determined by pallidus index (PI) increased as the disease severity (scored by Child Pugh ranking) worsened ( r = 0.353, P < 0.05). The changes in PI values were also linearly associated with Mn concentrations in whole blood (MnB) ( r = 0.814, P < 0.01).

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Fang, Tao, Zuoting Song, Gege Zhan, et al. "Decoding motor imagery tasks using ESI and hybrid feature CNN." Journal of Neural Engineering 19, no. 1 (2022): 016022. http://dx.doi.org/10.1088/1741-2552/ac4ed0.

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Abstract Objective. Brain–computer interface (BCI) based on motor imaging electroencephalogram (MI-EEG) can be useful in a natural interaction system. In this paper, a new framework is proposed to solve the MI-EEG binary classification problem. Approach. Electrophysiological source imaging (ESI) technology is used to solve the influence of volume conduction effect and improve spatial resolution. Continuous wavelet transform and best time of interest (TOI) are combined to extract the optimal discriminant spatial-frequency features. Finally, a convolutional neural network with seven convolution

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Werner, Rudolf A., Ralph A. Bundschuh, Lena Bundschuh, et al. "Molecular imaging reporting and data systems (MI-RADS): a generalizable framework for targeted radiotracers with theranostic implications." Annals of Nuclear Medicine 32, no. 8 (2018): 512–22. http://dx.doi.org/10.1007/s12149-018-1291-7.

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Węgiel, Michał, Marcin Surmiak, Krzysztof Piotr Malinowski, et al. "In-Hospital Levels of Circulating MicroRNAs as Potential Predictors of Left Ventricular Remodeling Post-Myocardial Infarction." Medicina 60, no. 1 (2024): 149. http://dx.doi.org/10.3390/medicina60010149.

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Background and Objectives: Biochemical and molecular regulation of both adaptive and pathological responses of heart tissue to ischemic injury is widely investigated. However, it is still not fully understood. Several biomarkers are tested as predictors of left ventricle (LV) remodeling after myocardial infarction (MI). The aim of this study was to assess the relationship between selected microRNAs (miRNAs) and LV function and morphology in patients after MI. Materials and Methods: Selected miRNAs related to heart failure were assessed in the acute phase of MI: miR-150-3p, miR-21-5p, miR-19b-3

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Caicedo-Acosta, Julian, German A. Castaño, Carlos Acosta-Medina, Andres Alvarez-Meza, and German Castellanos-Dominguez. "Deep Neural Regression Prediction of Motor Imagery Skills Using EEG Functional Connectivity Indicators." Sensors 21, no. 6 (2021): 1932. http://dx.doi.org/10.3390/s21061932.

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Motor imaging (MI) induces recovery and neuroplasticity in neurophysical regulation. However, a non-negligible portion of users presents insufficient coordination skills of sensorimotor cortex control. Assessments of the relationship between wakefulness and tasks states are conducted to foster neurophysiological and mechanistic interpretation in MI-related applications. Thus, to understand the organization of information processing, measures of functional connectivity are used. Also, models of neural network regression prediction are becoming popular, These intend to reduce the need for extrac

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Song, Min Ho, Jimeen Yoo, Do-A. Kwon, et al. "Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling." International Journal of Molecular Sciences 25, no. 11 (2024): 6262. http://dx.doi.org/10.3390/ijms25116262.

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Modified mRNAs (modRNAs) are an emerging delivery method for gene therapy. The success of modRNA-based COVID-19 vaccines has demonstrated that modRNA is a safe and effective therapeutic tool. Moreover, modRNA has the potential to treat various human diseases, including cardiac dysfunction. Acute myocardial infarction (MI) is a major cardiac disorder that currently lacks curative treatment options, and MI is commonly accompanied by fibrosis and impaired cardiac function. Our group previously demonstrated that the matricellular protein CCN5 inhibits cardiac fibrosis (CF) and mitigates cardiac dy

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Zulauf-Czaja, Anna, Bethel Osuagwu, and Aleksandra Vuckovic. "Source-Based EEG Neurofeedback for Sustained Motor Imagery of a Single Leg." Sensors 23, no. 12 (2023): 5601. http://dx.doi.org/10.3390/s23125601.

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The aim of the study was to test the feasibility of visual-neurofeedback-guided motor imagery (MI) of the dominant leg, based on source analysis with real-time sLORETA derived from 44 EEG channels. Ten able-bodied participants took part in two sessions: session 1 sustained MI without feedback and session 2 sustained MI of a single leg with neurofeedback. MI was performed in 20 s on and 20 s off intervals to mimic functional magnetic resonance imaging. Neurofeedback in the form of a cortical slice presenting the motor cortex was provided from a frequency band with the strongest activity during

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Awasthi, Vibhudutta, Hariprasad Gali, Andria F. Hedrick, Huining Da, Venkateswararao Eeda, and Diwakar Jain. "Positron Emission Tomography (PET) with 18F-FGA for Diagnosis of Myocardial Infarction in a Coronary Artery Ligation Model." Molecular Imaging 2022 (February 9, 2022): 1–10. http://dx.doi.org/10.1155/2022/9147379.

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Location and extent of necrosis are valuable information in the management of myocardial infarction (MI). Methods. We investigated 2-deoxy-2-18F-fluoro glucaric acid (FGA), a novel infarct-avid agent, for positron emission tomography (PET) of MI. We synthesized FGA from commercially available 18F-fluoro-2-deoxy-2-D-glucose (FDG). MI was induced in mice by permanently occluding the left anterior descending coronary artery. Biodistribution of FGA was assessed 1 h after FGA injection (11 MBq). PET/CT was conducted 1 h, 6 h, 1 d, 3 d, and 4 d after MI. Subcellular compartment of FGA accumulation i

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Li, Xun, Sanqing Hu, Lihua Li, and Shanan Zhu. "Numerical Study of Magnetoacoustic Signal Generation with Magnetic Induction Based on Inhomogeneous Conductivity Anisotropy." Computational and Mathematical Methods in Medicine 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/161357.

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Magnetoacoustic tomography with magnetic induction (MAT-MI) is a noninvasive imaging modality for generating electrical conductivity images of biological tissues with high spatial resolution. In this paper, we create a numerical model, including a permanent magnet, a coil, and a two-layer coaxial cylinder with anisotropic electrical conductivities, for the MAT-MI forward problem. We analyze the MAT-MI sources in two cases, on a thin conductive boundary layer and in a homogeneous medium, and then develop a feasible numerical approach to solve the MAT-MI sound source densities in the anisotropic

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Chaher, Nadia, Reza Hajhosseiny, Alkystis Phinikaridou, and René M. Botnar. "Imaging the Extracellular Matrix in Prevalent Cardiovascular Diseases." Applied Sciences 10, no. 11 (2020): 4001. http://dx.doi.org/10.3390/app10114001.

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The extracellular matrix (ECM) is a highly complex macromolecular network present in all tissues and organs. The ECM is continuously remodelling under an orchestrated process facilitated by many matrix-degrading and matrix-synthesising enzymes in both health and disease. Disturbance of this balance can be the result of or can lead to various diseases. In cardiovascular diseases (CVDs), changes to the ECM are evident in conditions including: atherosclerosis, myocardial infarction (MI), venous thromboembolism (VTE) and abdominal aortic aneurysm (AAA). ECM proteins and ECM regulating enzymes are

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Polo, Federico, Beatrice Polido, Mattia Reato, Giulia Moro, Neso Sojic, and Matteo Mauro. "(Invited) Heterobimetallic Ir^III-M^I (M^I = Au, Cu) Complexes: A Novel and Bright Alternative As Electrochemiluminescence Probes for Sensing and Imaging." ECS Meeting Abstracts MA2025-01, no. 60 (2025): 2903. https://doi.org/10.1149/ma2025-01602903mtgabs.

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Bimetallic complexes are rapidly emerging as a valid and attractive class of emitters. In this presentation, we will describe a recent work concerning the yet unexplored electrochemiluminescence (ECL) properties of a series of heterobimetallic complexes of general structure IrIII-MI belonging to the class of ionic transition metal complexes (iTMCs). In the IrIII-MI series, the formally neutral cyclometalated iridium complex provides efficient photo- and electro-active properties to the molecular emitters. Whereas bulky MI(gold or copper) metalloligand increases structural rigidity and chemical

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Nahrendorf, Matthias, Cristian Badea, Laurence W. Hedlund, et al. "High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT." American Journal of Physiology-Heart and Circulatory Physiology 292, no. 6 (2007): H3172—H3178. http://dx.doi.org/10.1152/ajpheart.01307.2006.

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The objective of this study was to determine the feasibility of delayed-enhancement micro-computed tomography (μCT) imaging to quantify myocardial infarct size in experimental mouse models. A total of 20 mice were imaged 5 or 35 days after surgical ligation of the left coronary artery or sham surgery ( n = 6 or 7 per group). We utilized a prototype μCT that covers a three-dimensional (3D) volume with an isotropic spatial resolution of 100 μm. A series of image acquisitions were started after a 200 μl bolus of a high-molecular-weight blood pool CT agent to outline the ventricles. CT imaging was

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Shan, Xiaoqin, Yunhan Zheng, and Rihong Zhu. "Self-Phase Modulation-Induced Instability of High-Power Narrow-Linewidth Fiber Amplifiers." Photonics 10, no. 12 (2023): 1330. http://dx.doi.org/10.3390/photonics10121330.

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In this study, we investigated the effect of self-phase modulation (SPM)-induced modulation instability (MI) on the spectral purity of high-power narrow-linewidth fiber amplifiers and established a spectral evolution model for SPM-induced MI in those amplifiers. The spectral evolution process of MI under different laser powers was simulated and analyzed. The results show that, at low power (100 W), SPM can cause a dynamic change in the spectral sideband secondary peak and the spectral wingspan. An increase in laser power led to the cascade effect of MI, forming a zigzag secondary sideband with

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Natarajan, Arutselvan, Farbod Tabesh, Dongwoon Hyun, Ramasamy Paulmurugan, and Jeremy Dahl. "Abstract LB115: Simultaneous whole-body ultrasound contrast imaging: a novel high throughput preclinical platform for targeted molecular imaging studies." Cancer Research 83, no. 8_Supplement (2023): LB115. http://dx.doi.org/10.1158/1538-7445.am2023-lb115.

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Abstract Ultrasound contrast agent (UCA) based molecular imaging is a rapidly growing field in biomedical research. Ultrasound (US) is a non-radiative imaging modality that is frequently used to investigate various human diseases in the clinic. US molecular imaging is a novel imaging modality that utilizes targeted contrast agents to add molecular information about the imaging target, including vascular biomarkers of cancer. Pre-clinical animal models are commonly used to evaluate and validate targeted contrast agents before extending them for FDA-approval. Key impediments in the preclinical e

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Yang, Wenwen, Yueqi Wang, Hongzheng Li, et al. "Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen." Biology 13, no. 4 (2024): 213. http://dx.doi.org/10.3390/biology13040213.

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The fibrosis process after myocardial infarction (MI) results in a decline in cardiac function due to fibrotic collagen deposition and contrast agents’ metabolic disorders, posing a significant challenge to conventional imaging strategies in making heart damage clear in the fibrosis microenvironment. To address this issue, we developed an imaging strategy. Specifically, we pretreated myocardial fibrotic collagen with collagenase I combined with human serum albumin (HSA-C) and subsequently visualized the site of cardiac injury by near-infrared (NIR) fluorescence imaging using an optical contras

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Barca, Cristina, Christoph Griessinger, Andreas Faust, et al. "Expanding Theranostic Radiopharmaceuticals for Tumor Diagnosis and Therapy." Pharmaceuticals 15, no. 1 (2021): 13. http://dx.doi.org/10.3390/ph15010013.

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Radioligand theranostics (RT) in oncology use cancer-type specific biomarkers and molecular imaging (MI), including positron emission tomography (PET), single-photon emission computed tomography (SPECT) and planar scintigraphy, for patient diagnosis, therapy, and personalized management. While the definition of theranostics was initially restricted to a single compound allowing visualization and therapy simultaneously, the concept has been widened with the development of theranostic pairs and the combination of nuclear medicine with different types of cancer therapies. Here, we review the clin

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Kang, S., K. D. Han, S. Lee, et al. "POS0211 ASSOCIATION BETWEEN CARDIOVASCULAR OUTCOME AND RHEUMATOID ARTHRITIS: NATIONWIDE POPULATION-BASED COHORT STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 342.2–342. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3579.

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BackgroundMany studies have shown increased risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA). Despite a growing burden posed by CVD in RA patients, large scale studies which examined the association between characteristic of RA patients and CVD risks, and studies which adjusted for various confounding factors are lacking.ObjectivesThis study aimed to investigate the association between CVD risk and RA in large-scale, nationwide cohort of Korean population, and to examine which characteristics of RA patients are associated with increased CVD risk.MethodsWe enrolle

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Sia, Ching-Hui, Sock-Hwee Tan, Siew-Pang Chan, et al. "Enhanced Thrombin Generation Is Associated with Worse Left Ventricular Scarring after ST-Segment Elevation Myocardial Infarction: A Cohort Study." Pharmaceuticals 15, no. 6 (2022): 718. http://dx.doi.org/10.3390/ph15060718.

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Acute myocardial infarction (AMI) is associated with heightened thrombin generation. There are limited data relating to thrombin generation and left ventricular (LV) scarring and LV dilatation in post-MI LV remodeling. We studied 113 patients with ST-segment elevation myocardial infarction (STEMI) who had undergone primary percutaneous coronary intervention (PPCI) (n = 76) or pharmaco-invasive management (thrombolysis followed by early PCI, n = 37). Endogenous thrombin potential (ETP) was measured at baseline, 1 month and 6 months. Cardiovascular magnetic resonance imaging was performed at bas

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Lin, Ben A., Joseph G. Akar, Rupak Mukherjee, et al. "Abstract 8449: Evaluation of Atrial Remodeling and Fibrillation Vulnerability Using Molecular Imaging of Matrix Metalloproteinases." Circulation 124, suppl_21 (2011). http://dx.doi.org/10.1161/circ.124.suppl_21.a8449.

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INTRODUCTION: Heart failure after myocardial infarction (MI) leads to atrial remodeling and fibrosis, thereby increasing vulnerability to atrial fibrillation (AF). While matrix metalloproteinase (MMP) activity is known to be an important mediator of left ventricular (LV) remodeling after MI, atrial MMP activation in this setting has not been well studied. HYPOTHESIS: We hypothesized that atrial structural remodeling and fibrillation vulnerability occurring early after MI can be noninvasively assessed using targeted molecular imaging of MMP activation. METHODS: In vivo and ex vivo SPECT/CT imag

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Van Den Borne, Susanne W., Satoshi Isobe, Johan Verjans, et al. "Abstract 1409: Molecular Imaging of Post-Infarction Cardiac Remodeling and Effects of Anti-Angiotensin Therapy." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_289-d.

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Background. Collagen deposition and interstitial fibrosis contribute to development of cardiac remodeling and heart failure (HF) after myocardial infarction (MI). We used Tc-99m-labeled Cy5.5-RGD imaging peptide (CRIP), for molecular imaging of the extent of collagen deposition. Methods. Of 46 Swiss-Webster mice, (MI) was induced in 41 by left coronary artery occlusion and 5 mice were imaged unmanipulated. Of these, 6, 6, and 5 mice, received intravenous CRIP for micro-SPECT/micro-CT imaging in vivo after 2, 4, and 12 weeks of MI. Eight mice received captopril or captopril with losartan for 4

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Hess, Annika, Tobias Borchert, Tobias L. Ross, Frank M. Bengel, and James T. Thackeray. "Characterizing the transition from immune response to tissue repair after myocardial infarction by multiparametric imaging." Basic Research in Cardiology 117, no. 1 (2022). http://dx.doi.org/10.1007/s00395-022-00922-x.

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AbstractPersistent inflammation following myocardial infarction (MI) precipitates adverse outcome including acute ventricular rupture and chronic heart failure. Molecular imaging allows longitudinal assessment of immune cell activity in the infarct territory and predicts severity of remodeling. We utilized a multiparametric imaging platform to assess the immune response and cardiac healing following MI in mice. Suppression of circulating macrophages prior to MI paradoxically resulted in higher total leukocyte content in the heart, demonstrated by increased CXC motif chemokine receptor 4 (CXCR4

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