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Relevant bibliographies by topics / Molecular immunology / Dissertations / Theses

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Dissertations / Theses on the topic 'Molecular immunology'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Johansson, Alina. "Molecular mechanisms behind TRIM28expression." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-252834.

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2

All-Ericsson, Charlotta. "Uveal melanoma : cytogenetics, molecular biology and tumor immunology /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-278-7.

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3

Eckert, Rachael. "Molecular Mechanisms of Neutrophil Migration." NCSU, 2007. http://www.lib.ncsu.edu/theses/available/etd-10312007-134315/.

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This work is an investigative look behind the mechanisms of neutrophil migration. Each of three chapters involves exploration into a different signaling pathway important for migration downstream of chemoattractant stimulation through inhibition of a kinase or disruption of the function of an effector and examination of the effects on migration, adhesion, and actin reorganization in primary human or equine neutrophils. Chapter II examines the requirement for the signaling molecule p38 Mitogen Activated Kinase (MAPK) in equine neutrophil chemotaxis through use of the p38 specific inhibitor SB20

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4

Wijewardana, Thula Gaurie. "Molecular immunology of bovine isolates of Pasteurella multocida type A." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/24424.

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5

Chou, Richard M. "Use of Phage Display Libraries to Select For B-cell Receptor-specific Peptides of Chronic Lymphocytic Leukemia Cells." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1346584096.

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6

Duarte, Nádia. "Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes." Doctoral thesis, Umeå universitet, Medicinsk biovetenskap, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-601.

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Type 1 diabetes is an autoimmune disorder determined both by genetic and environmental factors. The Non-obese diabetic (NOD) mouse is one of the best animal models of this disease. It spontaneously develops diabetes through a process resembling the human pathogenesis. The strong association of NOD Type 1 diabetes to the MHC region and the existence of other diabetes susceptibility loci are also in parallel with the human disease. The identity of the genetic factors and biological function mediated by these loci remain, however, largely unknown. Like in other autoimmune diseases, defects in tol

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7

Basak, Sanjukta. "Studies of Hepatitis C virus immunology : translation and replication." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97903.

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Hepatitis C virus (HCV) has become a worldwide problem. Roughly 3% of world population are estimated to be infected with the virus, producing high rates of progressive liver disease, leading to cirrhosis and hepatocellular carcinoma. The present therapy, a combined administration of pegylated interferon-alpha (IFN) and ribavirin is costly and only successful in 50% of patients infected with HCV. It is also associated with serious side effects. Thus, there is an urgent need for better tolerated and more effective treatment modalities. A therapeutic vaccine may be the solution.<br>Recent efforts

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8

Emani, Sirisha. "MOLECULAR CHARACTERIZATION OF T REGULATORY CELLS IN FIV-INFECTION." NCSU, 2006. http://www.lib.ncsu.edu/theses/available/etd-01192006-105756/.

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Naturally occurring CD4+CD25+ T regulatory cells (Treg) play important roles in maintaining immunologic self-tolerance in addition to controlling the magnitude of anti-microbial immune responses. However, the capacity of these CD4+CD25+ Treg cells to control immune responses both in vivo and in vitro is not well established. CD4+CD25+ Treg cell-mediated suppression can control autoimmune diseases; transplantation tolerance and graft verses host disease and, in contrast hinder tumor immunity and immunity to infectious agents. As Treg cells have been reported to be involved in several diseases,

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9

Schauenburg, Andrea J. A. "Molecular mechanisms underlying pMHC-II recognition." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/96291/.

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The immune system is a complex network of cells and molecules working together with the purpose of fending off potentially harmful pathogens. CD4+ T cells take key roles within this network by orchestrating a multitude of its players. They recognise pathogen or self-derived peptides (p) bound to molecules of the major histocompatibility class II (MHC-II) through their T cell receptor (TCR). Cytokines secreted in response to recognition aid antibody production and cytotoxic T cell activity, both critical for anti-viral immunity. In this thesis, TCR/pMHC-II interactions were investigated using a

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10

Huang, Bei. "Molecular interaction of the CD4 and MHC class II molecules : mapping the contact sites on CD4." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42056.

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T cells expressing CD4 recognize antigens presented by class II following the contact of CD4 with non-polymorphic regions of class II. CD4 enhances T cell activation by acting as an adhesion molecule (co-ligand function), or by bringing the CD4 associated p56$ sp{lck}$ to the vicinity of the TCR (co-receptor function).<br>To dissect the molecular interactions which lead to CD4 function(s), wild-type (WT) and mutant CD4 molecules were expressed in the CD4-dependent 3DT52.5.8 T cell hybridomas. Results showed that multiple sites on CD4 encompassing the CDR1, the CDR3 regions of D1 and the FG loo

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11

Martin, Bradley N. "The Cellular and Molecular Mechanisms of ASC-dependent Inflammasomes in Neuroinflammation." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459420965.

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12

Smith, Michael J. "Molecular modelling of MHC/peptide complexes." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297304.

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13

Wojciechowski, Wojciech. "Molecular mechanism of IFN-[gamma]-induced macrophage activation." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37667.

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Macrophages are considered as one of the early effector cells involved in the immunological response against infection. Following macrophages interaction with pathogens, macrophages become activated and attempt to eliminate the invader. Interferon gamma (IFN-gamma) is one of the most important activators of macrophage function. In macrophages IFN-gamma is promoting the expression of major histocompatibility complex class II (MHC-II) molecules and other proteins directly involved in the process of containing infection.<br>The effect of the Nramp1, on macrophage function is investigated in this

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14

Gliddon, Daniel. "The molecular basis of bovine dendritic cell functions." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272235.

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15

Wright, Ann Heather. "The molecular basis of leukocyte adhesion deficiency in six patients." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239257.

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16

Peaker, Christopher James Gordon. "A molecular analysis of the B-cell antigen receptor complex." Thesis, University of Cambridge, 1995. https://www.repository.cam.ac.uk/handle/1810/275263.

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17

Shah, Vaibhav. "Molecular and functional analysis of beta-glucan-mediated microglial activation." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1229705831.

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18

Yasmin, Mahmuda. "Molecular biology of fulminant hepatitis B viruses." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360121.

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19

Carmo, Alexandre V. X. M. do. "Molecular associations of proteins involved in signal transduction in T lymphocytes." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260113.

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20

Das, Amitava. "Chronic Inflammation: Molecular and Nutritional Interventions of Metabolic Disorder and its Complications." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461254458.

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21

Al-Mot, Sawsan. "Molecular signatures as a new classification scheme for chronic rhinosinusitus." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114268.

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Chronic Rhinosinusitis (CRS), an inflammation of the paranasal sinus cavities, is a common disorder of uncertain etiology that affects the upper airways and paranasal sinuses. Biopsy specimens had taken from CRS patients document disruption of the normal epithelial architecture, in addition to an intense infiltration of inflammatory cells, consisting mainly of eosinophils. Current clinical classification of CRS is based on the presence or absence of nasal polyposis; however, no consistent difference in histological aspect characterizes these two groups. Recently, we have identified distinct ge

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22

Birkenheuer, Adam Joseph. "Canine Babesiosis: Epidemiological, Molecular and Therapeutic Investigations." NCSU, 2004. http://www.lib.ncsu.edu/theses/available/etd-04192004-164025/.

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Canine babesiosis is an emerging infectious disease in the United States (US). An epidemic of Babesia gibsoni infections in the US was identified. An association between dog breed and B. gibsoni infections was detected. Babesia gibsoni-infected dogs were more likely to be American pit bull terriers and B. canis vogeli infected dogs were more likely to be greyhounds. An association between a recent dog bite and B. gibsoni infection was detected, implicating direct dog-to-dog transmission as a route of infection in the US. Several genes from canine Babesia spp. were characterized, including 18S

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23

Redpath, Stella. "Effector functions of human IgG." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363193.

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24

Moots, Robert J. "The fine specificity of HLA class I-restricted antigen recognition by cytotoxic T lymphocytes." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315327.

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25

Ho, Minh-Minh. "Complement protein C1q modulates macrophage molecular signaling and inflammatory responses during ingestion of atherogenic lipoproteins." Thesis, California State University, Long Beach, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10131681.

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<p>Foam cell formation from arterial intima macrophages and defective clearance of apoptotic foam cells drive the progression of the inflammatory disease atherosclerosis. The role of innate immune protein C1q in autoimmune disease and pathogen defense is well characterized, however its role in atherosclerosis remains largely uninvestigated. Prior studies have characterized the complement independent role of C1q in polarizing macrophages towards an anti-inflammatory phenotype during uptake of apoptotic cells and modified lipoproteins. To further understand the role of C1q in programming human m

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26

Alrammah, Hanaa. "The role of lysophosphatidylcholine acyltransferase-2 (LPCAT-2) in inflammatory responses." Thesis, University of Plymouth, 2018. http://hdl.handle.net/10026.1/11291.

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Sepsis is the overwhelming inflammatory response to infection, especially bacterial infection and associated bacterial products. It has major healthcare impacts, affecting an estimated 19-30 million persons/year worldwide with a mortality of 30-70%. Despite intense research, no specific therapy has been established for sepsis and in addition to the high mortality, the associated economic costs are very high. For example, recent data shows that the annual cost of patients with sepsis is more than $20 billion in the USA, and £2.5 billion in the UK. Therefore, novel targets and new therapies for

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27

Jaigirdar, Shafqat Ahrar. "Investigating the molecular mechanisms of CD4 T cell persistence at inflamed peripheral tissues." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8952/.

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CD4 T cells play an important role in the initiation and maintenance of inflammation in numerous inflammatory diseases. Rheumatoid arthritis (RA) is one such autoimmune inflammatory condition where inflammation of the joint occurs. CD4 T cells are one of the key cells in RA pathogenesis due to their ability to activate or influence other cells in the joint including B cells, macrophages and osteoclasts, which collectively lead to joint destruction. The recruitment and function of CD4 T cells at inflamed tissues has been studied extensively. However, the signals that regulate CD4 T cell accumul

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28

Thomas, Laura. "The molecular basis for preservative resistance in Burkholderia cepacia complex bacteria." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/14475/.

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Burkholderia cepacia complex bacteria can contaminate and survive in a variety of antimicrobial and preserved industrial products. Contamination may lead to economic loss for manufacturers and also potentially pose a risk to the health of vulnerable consumers. Understanding the interaction between Bcc bacteria and preservatives, and the molecular basis for their resistance, is essential in order to better target these organisms and to facilitate the implementation of improved preservative strategies which target resistance mechanisms. In the present study, multi-locus sequence typing analysis

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29

Dalziel, Catherine Ellen. "The molecular basis of adjuvant activity of pneumolysin." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5405/.

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Streptococcus pneumoniae is a major human pathogen and causes a significant burden of disease in both developed and developing countries. Currently, two pneumococcal vaccines are available, a polysaccharide conjugate vaccine for children <2 years of age and an adult polysaccharide vaccine for ‘at risk’ groups such as the elderly and immunocompromised. Unfortunately, due to the vast variation and highly recombinant nature of the pneumococcus vaccine escape through serotype replacement is significantly decreasing the efficacy of pneumococcal vaccines globally. New cost-effective and protective p

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30

Ma, Hoi-tung, and 馬凱彤. "Studies on the elements in the innate immune system of the shrimp, Penaeus monodon: from recognition, activationto melanization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42841501.

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31

Rahim, Rahimi Ali Akbar. "Molecular mechanisms for IL-10 induced CD14 expression in human monocytic cells." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26752.

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IL-10, an immunoregulatory cytokine with biological effects primarily on inhibition of inflammatory responses, has also been shown to stimulate a variety of functions including CD14 expression on human monocytic cells. CD14, a receptor for lipopolysaccharide (LPS), plays a critical role in the synthesis of proinflammatory cytokines by LPS-stimulated monocytic cells. Herein, I show that LPS-induced CD14 expression on monocytic cells may be mediated by endogenously produced IL-10. In this study, I have investigated the molecular mechanisms by which IL-10 enhances CD14 expression in normal human

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32

Wilson, Eleanor. "Characterising the molecular function of the Rho GTPase RhoJ in endothelial cells." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5363/.

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RhoJ is an endothelial expressed Rho GTPase that localises to focal adhesions and regulates cell migration and tube formation. Previous work in our laboratory determined that RhoJ activation negatively regulates focal adhesion (FA) numbers, and interacts with the FA proteins GIT1 and β-PIX. The studies presented in this thesis aimed to characterise the role of RhoJ in modulating FA dynamics, further investigate its interactions with the GIT/PIX complex, and generate a RhoJ knockout mouse to determine its function in vivo. Silencing RhoJ led to prolonged FA disassembly in migrating human umbili

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33

鍾婉茹 and Yuen-yue Yvonne Chung. "Immunological and molecular studies of antigens from trichinellid nematodes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31213054.

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34

Chung, Yuen-yue Yvonne. "Immunological and molecular studies of antigens from trichinellid nematodes /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19668326.

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35

Levi, Michael. "The use of peptides for studying molecular events in HIV and HSV infection /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2784-7/.

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36

Bucsu, Eva. "Plasmodium chabaudi adami : vaccine antigens and antigenic variation /." Connect to thesis, 2003. http://repository.unimelb.edu.au/10187/2881.

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There is an abundance of information available on the molecular mechanisms of antigenic variation in Plasmodium falciparum. The variant antigen PfEMP1, which mediates antigenic variation as well as cytoadherence and rosetting, has been extensively characterised. Genes coding for the antigen belong to the gene family var, and several var genes have been cloned and characterised. The rodent malaria parasite P. chabaudi is a widely studied in vivo model for P. falciparum. The P. c. chabaudi AS parasite strain has been shown to exhibit antigenic variation and the variant antigen has been detected

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37

Godec, Jernej. "Molecular Mechanisms of CD8+ T Cell Differentiation." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493424.

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CD8+ T cells are a crucial component of the adaptive immune system and are required for optimal protection from most pathogens and cancer. They function by secreting pro-inflammatory cytokines and by directly eliminating infected and malignant cells. In order to be effective, CD8+ T cells must be activated through a complex sequence of steps involving engagement of the antigen-specific T cell receptor (TCR) and other receptors, which orchestrate transcriptional, epigenetic, and metabolic changes that direct the differentiation of the responding cells. Following optimal activation, naive CD8+ T

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38

Portman, Jonathan Lewis. "Virulence Factor Regulation in Listeria monocytogenes." Thesis, University of California, Berkeley, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10620349.

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<p> <i>Listeria monocytogenes</i> is a Gram-positive intracellular pathogen that is readily amenable to genetic manipulation and for which there are excellent <i>in vitro</i> and <i>in vivo </i> virulence models. These attributes have allowed a thorough examination of the molecular underpinnings of <i>L. monocytogenes</i> pathogenesis, however, there are still a number of major unresolved questions that remain to be answered. For example, it has been known for many years that <i> L. monocytogenes</i> rapidly changes its transcriptional profile upon access to the host cytosol, however the host

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39

Mudenda, Lwiindi. "Identification of Dermacentor andersoni saliva proteins that modulate mammalian phagocyte function." Thesis, Washington State University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3717421.

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<p> Ticks are obligate blood sucking parasites which transmit a wide range of pathogens worldwide including protozoa, bacteria and viruses. Additionally, tick feeding alone may result in anemia, dermatosis and toxin-induced paralysis. <i> Dermacentor andersoni</i> is a species of tick found in the western United States that transmits pathogens of public health importance including <i> Rickettsia rickettsii, Francisella tularensis,</i> and Colorado Tick Fever Virus, as well as <i>Anaplasma marginale</i>, a rickettsial pathogen that causes economic losses in both the dairy and beef industries wo

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40

Chirieleison, Steven Morrow. "XIAP-MEDIATED INNATE IMMUNE SIGNALING IN INFLAMMATORY BOWELDISEASE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1499435128937345.

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41

Oldridge, Joanne. "Molecular and immunological characterisation of two vaccine dominant antigens of Schistosoma mansoni." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307435.

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42

Wedderburn, Lucy Rachel. "Molecular analysis of T cell receptors : mapping T cell recognition and repertoire in two human immune responses." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261721.

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43

Chatterjee, Avijit. "Vitamin A and measles : cellular and molecular analysis." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31206.

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Measles virus (MV) infects up to 40 million individuals each year, leading to one million deaths. MV can infect a wide variety of cell types including cells of the immune system. Although vitamin A (retinal) supplements can significantly reduce measles-associated mortality, the mechanism(s) remains unknown. We adopted a three-pronged approach to investigate vitamin A modulation of measles infection of human immune cells. We found that, at 1muM, both retinoic acid and retinol (ROH) with or without retinol binding protein (RBP) decreased MV production by 33% +/- 24% (p < 0.001), 37% +/- 20% (p <

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44

Im, Jin Seon. "Molecular characterization of T cell receptors and non-MHC restricted T cell receptor binding peptides." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284969.

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T cells recognize antigenic peptides presented by MHC molecules on antigen presenting cells (APC) through T cell receptors (TCRs). Since TCRs are very similar to antibodies in structure and genetics, TCRs might have the potential to bind free antigens as antibodies do. Here, peptides which bound TCRs irrespective of MHC molecules have been identified by screening "one-bead one-peptide" combinatorial libraries. Peptides: VRENAR, RTGNYV, GKMHFK, KDAVKR and RKPQAI bound recombinant Jurkat single chain T cell receptors (scTcrs). GKMHFK, KDAVKR and RKPQAI were also specific for natural TCRs on the

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45

Tabbaa, Omar Peter. "Stochastic and Multi-scale Modeling in Biology and Immunology." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1416498545.

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46

Tessmer, Marlowe S. "Biological functions and molecular associations of the killer cell lectin-like receptor G1." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318364.

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47

Girard, Tanya. "Role of CD80 and CD86 cosignaling proteins functional domains in molecular structure and adaptive immune responses." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103159.

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The initiation of adaptive immune responses requires the interactions of T cells with antigen presenting cells (APC) in the context of an immunological synapse (IS). Naive T cell responses are dependent on the engagement of CD28 and CTLA-4 by CD86 and CD80, respectively amplifying and dampening the antigen specific signal. CD80 and CD86 cosignaling molecules display three major domains: a membrane distal IgV-like domain, a membrane proximal IgC-like domain and an intracellular domain. Crystallographic data has shown that only the IgV domain of CD80 and CD86 physically interacts with CTLA-4. Ho

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48

McBerry, Cortez. "Cellular and Molecular Mechanisms of Immunoregulation In Vivo." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1354296472.

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49

Wong, Raymond Kah-Meng. "Molecular characterization of the regulation of endothelial barrier function during inflammation." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/279800.

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A major feature of inflammation is the extravasation of cellular and macromolecular components of blood into the interstitium to attack and fend off an offending stimuli, thus initiating healing. When prolonged and/or uncontrolled, this process can begin to produce deleterious effects and inadvertently damage tissue. Such instances are observed in pathologies, such as atherosclerosis, organ transplant rejection and reperfusion injury. It is therefore vital to understand the various mechanisms that initiate and control the process of extravasation. Since the endothelium is the key component bet

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50

Sala, Hojman Ada. "Molecular mechanisms involved in the immunomodulation induced by LIF in cancer." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/398852.

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LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that in tumors expressing LIF, its blockade inhibits tumor growth, and that the anti-tumor effect of LIF neutralization is mediated by the polarization of tumor-associated myeloid cells (TAMCs). LIF sustains the expression of CCL22, MRC1 and CD163 in human healthy monocytes and in TAMCs from mouse syngeneic (non-small cell lung cancer, ovarian cancer and colorectal cancer) models,

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