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Dissertations / Theses on the topic 'Molecular markers'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Cai, Na. "Molecular markers of stress." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:95826e79-6ef0-4148-8478-5778994f97fc.

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Using data from the China, Oxford and Virginia Commonwealth University Experimental Research on Genetic Epidemiology (CONVERGE) Consortium study of major depressive disorder (MDD)on 11,670 Han Chinese women, this thesis describes an investigation on the etiology of MDD, a psychiatric disease that has eluded previous genetic studies as well as investigations of its mechanistic underpinnings. It asks: what happens during stress, how may it contribute to the risk of developing MDD, and why does it increase the risk of MDD in some people but not others. It presents three main findings. First, a GW

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2

Pinto, Diana Maria de Figueiredo. "Molecular markers for diabetic nephropathy." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15953.

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Mestrado em Bioquímica - Bioquímica Clínica<br>Type 2 diabetes is one of the most common metabolic disorders in the world. Globally, the prevalence of this disorder is predicted to increase, along with the risk of developing diabetic related complications. One of those complications is diabetic nephropathy, defined by a progressive increase in proteinuria and a gradual decline in renal function. Approximately 25% to 30% of type 2 diabetic individuals develop this complication. However, its underlying genetic mechanisms remain unclear. Thus, the aim of this study is to contribute to the discove

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3

Weigelt, Britta. "Molecular markers of breast cancer metastasis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/88848.

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4

Swagell, Christopher Dean. "Molecular markers of obesity and diabetes." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/35762/1/Christopher_Swagell_Thesis.pdf.

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Recently it has been shown that the consumption of a diet high in saturated fat is associated with impaired insulin sensitivity and increased incidence of type 2 diabetes. In contrast, diets that are high in monounsaturated fatty acids (MUFAs) or polyunsaturated fatty acids (PUFAs), especially very long chain n-3 fatty acids (FAs), are protective against disease. However, the molecular mechanisms by which saturated FAs induce the insulin resistance and hyperglycaemia associated with metabolic syndrome and type 2 diabetes are not clearly defined. It is possible that saturated FAs may act t

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5

Bitalo, Daphne Nyachaki. "Implementation of molecular markers for triticale cultivar identification and marker-assisted selection." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71670.

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Thesis (MSc)--Stellenbosch University, 2012.<br>Triticale is an amphidiploid that consists of wheat (A and B) and rye (R) genomes. This cereal is fast becoming important on a commercial basis and warrants further assessment for the better management and breeding of the hybrid. The assessment of the genetic diversity among the wheat and rye genomes within triticale can be obtained by using molecular markers developed in both donor genomes. Simple sequence repeats markers (SSRs) and amplified fragment length markers (AFLPs) have been previously used to assess the genetic diversity among tritical

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6

Valdman, Alexander. "Molecular genetic markers of prostate cancer development /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-618-9/.

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7

Larkin, Samantha. "Molecular characterisation of prostate cancer progression markers." Thesis, University of Portsmouth, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511205.

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8

Steele, Katherine A. "Molecular markers in yellow rust of wheat." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243712.

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9

Hemmings, Karen Emily. "Cellular and molecular markers of oocyte quality." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445945.

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10

Laird, Alexander. "Molecular prognostic markers in renal cell carcinoma." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17873.

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Renal cell carcinoma (RCC) is the most deadly of urological malignancies. While metastatic disease affects one third of patients at diagnosis, a further third of patients who undergo extirpative surgery with curative intent subsequently develop metastatic disease. Inconsistency in the clinical course ensures predicting subsequent metastasis is notoriously difficult, despite the routine use of prognostic clinico-pathological parameters in risk stratification. With greater understanding of pathways involved in disease pathogenesis, a number of biomarkers have been proposed to be of prognostic si

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11

Cooper, Grace. "Molecular Markers of Alzheimer’s and Parkinson’s Diseases." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523975395945636.

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12

Farr, Ryan. "Molecular Markers of Pancreatic β-cell Death". Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17308.

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Abstract Loss of insulin-producing β-cells is central to the development of Type 1 diabetes (T1D). Currently, we lack diagnostic tools to quantitate this β-cell loss. Non-protein coding RNAs called microRNAs (miRNAs/miRs) play an important role in islet development and function. Recent detection of miRNAs in peripheral circulation, has renewed interest in microRNA biomarkers of diabetes. Comparably, circulating insulin cell-free (cf)DNA has been proposed as a direct biomarker of β-cell death. DNA methylation studies have identified specific sites within DNA that are unmethylated in β-cells but

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13

Sarela, Abeezar Ismail. "Molecular genetic markers of prognosis in colorectal carcinoma." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438485.

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14

Cao, Wenguang. "Wheat taxonomy and cultivar identification using molecular markers." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24007.pdf.

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15

Stoltzfus, Patricia. "Molecular markers reflecting malignant transformation and tumor progression /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-888-2.

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16

Tascilar, Metin. "Clinical significance of molecular markers in pancreatic cancer." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/61858.

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17

Hopwood, N. D. "Molecular markers of mesoderm induction in Xenopus laevis." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317830.

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18

Kawesha, Anthony. "Prognostic molecular markers in resected ductal pancreatic carcinoma." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7596/.

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Previous studies of molecular prognostic markers following resection for exocrine pancreatic cancer have produced conflicting results. The aim of this study was to undertake a comprehensive analysis of potentially useful markers in a large multicentre patient population and compare these markers with standard pathological prognostic variables. Formalin fixed, paraffin-embedded specimens of pancreatic ductal adenocarcinoma were analysed from 157 patients (100 men and 57 women with a median [range] age of 60 [33-77] years) who had undergone pancreatectomy. Immunhistochemistry was used to detect

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19

Hu, Jiahuai. "Phytophthora nicotianae: Fungicide Sensitivity, Fitness, and Molecular Markers." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/26416.

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Mefenoxam has been a premier compound for Phytophthora disease control in the nursery industry for 30 years. The primary objectives of this research were to examine whether Phytophthora species have developed resistance to this compound and to investigate fungicide resistance management strategies. Phytophthora nicotianae, a destructive pathogen of numerous herbaceous and some woody ornamental plants, was used as a model system. P. cinnamomi, a major pathogen of a wide range of tree species and shrub plants, was also included for comparison. Twenty-six isolates of P. nicotianae were highly res

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20

au, Constantine@wehi edu, and Clare Constantine. "Molecular markers, analysis and the population genetics of parasites." Murdoch University, 2002. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20050817.102006.

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In this study different molecular techniques are contrasted (RAPD's, allozyme, sequencing mtDNA, sequencing ribosomal spacers) and appropriate analytical methods (allelic and infinite-sites approaches; inbreeding and coalescent models) used for estimating population genetic parameters in parasites. A range of population genetic questions at different scales were chosen to emphasise the importance of tailoring techniques and analytical methods to the particular question being investigated. The realisation that each question formulated has a particular scale means the appropriate technique and

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21

Constantine, Clare. "Molecular markers, analysis and the population genetics of parasites." Constantine, Clare (2002) Molecular markers, analysis and the population genetics of parasites. PhD thesis, Murdoch University, 2002. http://researchrepository.murdoch.edu.au/662/.

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In this study different molecular techniques are contrasted (RAPD's, allozyme, sequencing mtDNA, sequencing ribosomal spacers) and appropriate analytical methods (allelic and infinite-sites approaches; inbreeding and coalescent models) used for estimating population genetic parameters in parasites. A range of population genetic questions at different scales were chosen to emphasise the importance of tailoring techniques and analytical methods to the particular question being investigated. The realisation that each question formulated has a particular scale means the appropriate technique an

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22

Hoerder, Anna. "Mouse cortical subplate neurones : molecular markers, connectivity and development." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442449.

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23

Conway, Caroline Anne. "Identification of molecular markers of prognosis in malignantm melanoma." Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496124.

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24

Cheung, Nga-yin Annie, and 張雅賢. "Cervical cancer screening: evolution from Paptest to molecular markers." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46540465.

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25

Chapman, Natalie HeÌleÌ€ne. "Identification and mapping of molecular markers for eyespot resistance." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426603.

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26

Leal, Soraya Cristina de Macedo. "Detection and characterization of Metarhizium anisopliae using molecular markers." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307762.

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27

Hall, Nicola. "Stable isotopes, molecular markers and water use in Brassicas." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324874.

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28

Allender, Charlotte Jane. "Molecular markers and the speciation of African cichlid fish." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394101.

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29

Burrows, Kimberley. "Molecular genetic epidemiology studies of quantitative nucleic acid markers." Thesis, University of Bristol, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761240.

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30

Plata-Muñoz, Juan José. "Clinical, biochemical and molecular markers of injury before transplantation." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572681.

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The use of organs from donors after circulatory death (DCD) has been recommended as one strategy to enlarge the donor pool and raise the transplant rate. However, DCD allografts had higher incidence of early post-transplant dysfunction. The general aim of this research project was to develop clinical and experimental strategies to reduce the incidence of early post-transplant dysfunction of kidney and liver allografts from DCD. First the ability of a clinical scoring system based on donor data for identifying DCD kidneys with high-risk of post-transplant dysfunction was evaluated using the Oxf

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31

Schrag, Tobias A. "Prediction of hybrid performance in maize using molecular markers." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:100-opus-3035.

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32

Poli, Maurizio. "Novel molecular markers for assessment of human embryo competence." Thesis, University of Oxford, 2016. http://ora.ox.ac.uk/objects/uuid:4c5bffff-d12c-4df1-b5f0-1459298fc45c.

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In vitro fertilization treatments are responsible for 1-5&percnt; births in industrialized countries. The safest way to generate a pregnancy is to transfer a single embryo to the mother, reducing the likelihood of multiple gestations. Hence, in order to maximize the chance of success, it is extremely important that the embryo prioritised for transfer is the most capable within the cohort of embryos generated by the patient. Along with cytogenetic components, it has been suggested that embryo protein expression patterns may correlate with its ability to implant. However, embryo proteomics strat

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33

Constantine, Clare Colleen. "Molecular markers, analysis and the population genetics of parasites." Thesis, Constantine, Clare Colleen (2002) Molecular markers, analysis and the population genetics of parasites. PhD thesis, Murdoch University, 2002. https://researchrepository.murdoch.edu.au/id/eprint/662/.

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In this study different molecular techniques are contrasted (RAPD's, allozyme, sequencing mtDNA, sequencing ribosomal spacers) and appropriate analytical methods (allelic and infinite-sites approaches; inbreeding and coalescent models) used for estimating population genetic parameters in parasites. A range of population genetic questions at different scales were chosen to emphasise the importance of tailoring techniques and analytical methods to the particular question being investigated. The realisation that each question formulated has a particular scale means the appropriate technique an

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34

Constantine, Clare Colleen. "Molecular markers, analysis and the population genetics of parasites /." Access via Murdoch University Digital Theses Project, 2002. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20050817.102006.

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35

Ambrosini, Spaltro Andrea <1978&gt. "Immunohistochemical and Molecular Prognostic/Predictive Markers in Neoplastic Diseases." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4309/1/ambrosinispaltro_andrea_tesi.pdf.

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Traditional morphological examinations are not anymore sufficient for a complete evaluation of tumoral tissue and the use of neoplastic markers is of utmost importance. Neoplastic markers can be classified in: diagnostic, prognostic and predictive markers. Three markers were analyzed. 1) Insulin-like growth factor binding protein 2 (IGFBP2) was immunohistochemically examined in prostatic tissues: 40 radical prostatectomies from hormonally untreated patients with their preoperative biopsies, 10 radical prostatectomies from patients under complete androgen ablation before surgery and 10 simple

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36

Ambrosini, Spaltro Andrea <1978&gt. "Immunohistochemical and Molecular Prognostic/Predictive Markers in Neoplastic Diseases." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4309/.

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Traditional morphological examinations are not anymore sufficient for a complete evaluation of tumoral tissue and the use of neoplastic markers is of utmost importance. Neoplastic markers can be classified in: diagnostic, prognostic and predictive markers. Three markers were analyzed. 1) Insulin-like growth factor binding protein 2 (IGFBP2) was immunohistochemically examined in prostatic tissues: 40 radical prostatectomies from hormonally untreated patients with their preoperative biopsies, 10 radical prostatectomies from patients under complete androgen ablation before surgery and 10 simple

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37

BERZERO, GIULIA. "“MOLECULAR MARKERS IN DIFFUSE GLIOMAS: DIAGNOSTIC AND THERAPEUTIC TARGETS”." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1371676.

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Due to their capital diagnostic, prognostic and therapeutic implications, molecular markers have become essential for the management of patients with diffuse gliomas. Among them, IDH mutations have special importance, as they allow to classify diffuse gliomas, they are predictive of prolonged survival and increased sensitivity to alkylating agents and can be targeted by specific inhibitors. IDH-mutant diffuse gliomas deeply differ from IDH-wildtype diffuse gliomas in terms of molecular profile, prognosis and treatment, as different are the pathways of gliomagenesis and progression in the two g

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38

AMOROSO, ALFREDO. "Development of new molecular markers in immunohematology and oncology." Doctoral thesis, Università del Piemonte Orientale, 2014. http://hdl.handle.net/11579/58206.

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39

LA, CORTE EMANUELE. "CLINICAL AND MOLECULAR BIO-MARKERS IN SKULL BASE CHORDOMAS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/610397.

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Introduzione. I cordomi della base cranica sono tumori rari e a lenta crescita derivanti dalla notocorda. La loro morbilità è principalmente legata alla loro invasione locale e alla resistenza ai trattamenti. A causa del loro aspetto eterogeneo e del loro comportamento clinico-molecolare non completamente compreso, l'obiettivo principale del presente lavoro è quello di identificare marcatori clinici e bio-molecolari come fattori prognostici specifici che potrebbero essere utilizzati per la corretta gestione di tali pazienti. Il raggiungimento di una firma prognostica dettagliata dei cordomi de

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40

Ishiy, Felipe Augusto André. "Evaluation of molecular markers in osteogenic differentiation of mesenchymal stem cells." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-20032017-104921/.

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The use of stem cells is a promising therapeutic approach for tissue engineering by their ability to boost tissue regeneration, and to model in vitro human genetics disorders since it provides continuous supplies of cells with differentiation potential. Our study has been focused in the identification of molecules or mechanisms that could contribute to a better osteogenesis in mesenchymal stem cells (MSC). To achieve our goals we have explored the osteopontential differences of stem cells from different sources. In this regard, we have observed that MSCs from human exfoliated deciduous teeth (

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41

Bernal, Sierra Yinth Andrea [Verfasser]. "Molecular markers of mechanoreceptors and potential molecules for gating mechanotransduction / Yinth Andrea Bernal Sierra." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1045194972/34.

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42

Jung, Renata. "Identification of Molecular Markers for Marker-Assisted Selection of Malting Quality and Associated Traits in Barley." Diss., North Dakota State University, 2015. http://hdl.handle.net/10365/25241.

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Barley (Hordeum vulgare L.) is one of the most important cereal crops in North Dakota, which ranks second amongst all states for barley production in the United States. Barley is used for the production of malt, which is used for brewing beer. The malting and brewing industries set strict standards for malt quality; yet, determining malt quality of experimental barley lines is very expensive. For this reason, quality is typically determined at the latter stages of the breeding program, resulting in rejection of many genotypes after large investments for agronomic performance, disease resistanc

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43

Poulsen, David Malcolm Ernest. "Application of molecular markers to breeding barleys for disease resistance /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17378.pdf.

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44

Bin, Kaderi Mohamed Arifin. "Assessment of Novel Molecular Prognostic Markers in Chronic Lymphocytic Leukemia." Doctoral thesis, Uppsala universitet, Hematologi och immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110371.

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The clinical course of chronic lymphocytic leukemia (CLL) is highly heterogeneous, which has prompted the search for biomarkers that can predict prognosis in this disease. The IGHV gene mutation status and certain genomic aberrations have been identified as reliable prognostic markers of clinical outcome for this disorder. However, the search for more feasible prognostic markers in CLL is still being pursued. Recently, certain single nucleotide polymorphisms (SNPs) in the GNAS1, BCL2 and MDM2 genes and the RNA expression levels of the LPL, ZAP70, TCL1, CLLU1 and MCL1 genes were suggested as no

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45

Laatio, L. (Liisa). "In search of new prognostic molecular markers in ovarian cancer." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514298349.

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Abstract Ovarian cancer is the leading cause of death from gynaecological cancers in the Western world. Ovarian cancer comprises of tumours with distinct behaviour and individually different responses to chemotherapy, even within the same histology. Unfortunately, there are no molecular markers in clinical use to either distinguish between patients with better and worse prognosis or to predict individual chemosensitivity. The comprehension of the molecular effects of chemotherapeutic drugs is a prerequisite for finding predictive molecular factors for chemoresponse and prognosis. Some proteins

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46

Scullin, P. "Molecular markers of response to systemic therapy in prostate cancer." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492490.

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Prostate cancer is a significant health problem worldwide. Glucocorticoids, including' dexamethasone have formed the backbone of treatment of androgenindependent disease for the past 50 years and are given with docetaxel in the only therapy with a proven survival benefit in this setting. This study explored the mecha'nism of dexamethasone action in the treatment of androgen-independent prostate cancer (AIPC). In the in vitro study' dexamethasone administration induced a suppression of NFKB transcriptional activity in AIPC cells, resulting in a decreased transcription . arid/or secretion of the

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47

Ponza, Pattareeya, and pattareeya pon@biotec or th. "Molecular markers of ecotoxicological interest in the rainbowfish Melanotaenia fluviatilis." RMIT University. Applied Science, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080102.121231.

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The Crimson-spotted rainbowfish (Melanotaenia fluviatilis) from the Murray-Darling basin of Australia is a common indicator species in Australian ecotoxicology. Biochemical changes have been investigated in this species, but not molecular markers of ecotoxicological interest. In this study genes of M. fluviatilis were isolated using a cDNA library and sequences analysed. Of 345 randomly selected clones, 94 shared similarity with 26 different genes in other organisms in public databases. Amongst these, reproductive genes coding for vitellogenin, retinol binding protein, sialyltransferase and zo

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48

Tar'an, Bunyamin. "Development and application of molecular markers in common bean breeding." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/NQ47413.pdf.

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49

Luan, Shi-Lu. "Molecular epidemiology of Streptococcus agalactiae : mobile elements as genetic markers /." Doctoral thesis, Umeå : Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-877.

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50

Mazhar, Kehkashan. "Molecular genetic markers for selection and genome mapping in cattle." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260797.

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