Relevant bibliographies by topics / Molecular Modifications

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Molecular Modifications'

Author: Grafiati
Published: 6 September 2023
Last updated: 31 July 2025

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Journal articles on the topic "Molecular Modifications"

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Abbas, Sk Jahir, Sabina Yesmin, Sandeepa K. Vittala, et al. "Target Bioconjugation of Protein Through Chemical, Molecular Dynamics, and Artificial Intelligence Approaches." Metabolites 14, no. 12 (2024): 668. https://doi.org/10.3390/metabo14120668.

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Covalent modification of proteins at specific, predetermined sites is essential for advancing biological and biopharmaceutical applications. Site-selective labeling techniques for protein modification allow us to effectively track biological function, intracellular dynamics, and localization. Despite numerous reports on modifying target proteins with functional chemical probes, unique organic reactions that achieve site-selective integration without compromising native functional properties remain a significant challenge. In this review, we delve into site-selective protein modification using
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Rehpenn, Andreas, Alexandra Walter, and Golo Storch. "Molecular Editing of Flavins for Catalysis." Synthesis 53, no. 15 (2021): 2583–93. http://dx.doi.org/10.1055/a-1458-2419.

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AbstractThe diverse activity of flavoenzymes in organic transformations has fascinated researchers for a long time. However, when applied outside an enzyme environment, the isolated flavin cofactor only shows largely reduced activity. This highlights the importance of embedding the reactive isoalloxazine core of flavins in defined surroundings. The latter include crucial non-covalent interactions with amino acid side chains or backbone as well as controlled access to reactants such as molecular oxygen. Nevertheless, molecular flavins are increasingly applied in the organic laboratory as valuab
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Li, Yinglu, Zhiming Li, and Wei-Guo Zhu. "Molecular Mechanisms of Epigenetic Regulators as Activatable Targets in Cancer Theranostics." Current Medicinal Chemistry 26, no. 8 (2019): 1328–50. http://dx.doi.org/10.2174/0929867324666170921101947.

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Epigenetics is defined as somatically inheritable changes that are not accompanied by alterations in DNA sequence. Epigenetics encompasses DNA methylation, covalent histone modifications, non-coding RNA as well as nucleosome remodeling. Notably, abnormal epigenetic changes play a critical role in cancer development including malignant transformation, metastasis, prognosis, drug resistance and tumor recurrence, which can provide effective targets for cancer prognosis, diagnosis and therapy. Understanding these changes provide effective means for cancer diagnosis and druggable targets for better
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Eichler, Jerry, and Michael W. W. Adams. "Posttranslational Protein Modification in Archaea." Microbiology and Molecular Biology Reviews 69, no. 3 (2005): 393–425. http://dx.doi.org/10.1128/mmbr.69.3.393-425.2005.

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SUMMARY One of the first hurdles to be negotiated in the postgenomic era involves the description of the entire protein content of the cell, the proteome. Such efforts are presently complicated by the various posttranslational modifications that proteins can experience, including glycosylation, lipid attachment, phosphorylation, methylation, disulfide bond formation, and proteolytic cleavage. Whereas these and other posttranslational protein modifications have been well characterized in Eucarya and Bacteria, posttranslational modification in Archaea has received far less attention. Although ar
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Winter, Stefan, and Wolfgang Fischle. "Epigenetic markers and their cross-talk." Essays in Biochemistry 48 (September 20, 2010): 45–61. http://dx.doi.org/10.1042/bse0480045.

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Post-translational modifications of histone proteins in conjunction with DNA methylation represent important events in the regulation of local and global genome functions. Advances in the study of these chromatin modifications established temporal and spatial co-localization of several distinct ‘marks’ on the same histone and/or the same nucleosome. Such complex modification patterns suggest the possibility of combinatorial effects. This idea was originally proposed to establish a code of histone modifications that regulates the interpretation of the genetic code of DNA. Indeed, interdependenc
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Miki, Keishu, Takeshi Watanabe, and Shinji Koh. "Electrochemical Characterization of CVD-Grown Graphene for Designing Electrode/Biomolecule Interfaces." Crystals 10, no. 4 (2020): 241. http://dx.doi.org/10.3390/cryst10040241.

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In research on enzyme-based biofuel cells, covalent or noncovalent molecular modifications of carbon-based electrode materials are generally used as a method for immobilizing enzymes and/or mediators. However, the influence of these molecular modifications on the electrochemical properties of electrode materials has not been clarified. In this study, we present the electrochemical properties of chemical vapor deposition (CVD)-grown monolayer graphene electrodes before and after molecular modification. The electrochemical properties of graphene electrodes were evaluated by cyclic voltammetry an
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Wang, Ya-Nan, Chen-Yang Yu, and Hong-Zhong Jin. "RNA N6-Methyladenosine Modifications and the Immune Response." Journal of Immunology Research 2020 (January 21, 2020): 1–6. http://dx.doi.org/10.1155/2020/6327614.

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N6-methyladenosine (m6A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m6A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m6A modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating m6A modifications of RNA have developed rapidly. This article reviews the biological significance of RNA m6A modifications in the innate immune response,
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Han, Dali, and Meng Michelle Xu. "RNA Modification in the Immune System." Annual Review of Immunology 41, no. 1 (2023): 73–98. http://dx.doi.org/10.1146/annurev-immunol-101921-045401.

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Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In this review, we discuss the value of innovative RNA modification profiling technologies to uncover the function of these diverse, dynamic RNA modifications in various immune cells within healthy and diseased contexts. Further, we explore our current understanding of the mechanisms whereby aberrant RNA modifications modulate the immune milieu of the tumor micro
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Chukwuma Sr, Chrysanthus. "Characterization of the Clinical and Molecular Perspectives of Epigenetics." Archives of Clinical Investigation 1, no. 1 (2022): 01–07. http://dx.doi.org/10.31579/2834-8087/003.

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This review provides the latitude to examine the extant information in the univeral characterizations of epigenetic formulations. Epigenetics encompasses the interaction of behaviours and environment culminating in changes which influence gene activity. In contrast to genetic modifications, epigenetic modifications are reversible; and do not alter the DNA sequence but are capable of interferring in the way the DNA sequence is read. Epigenetic alterations involve genetic changes which effect gene functionality without modifying the underlying DNA sequence. DNA methylation depicts the covalent s
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Carson, Spencer, James Wilson, Aleksei Aksimentiev, Peter R. Weigele, and Meni Wanunu. "Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA." Nucleic Acids Research 44, no. 5 (2015): 2085–92. http://dx.doi.org/10.1093/nar/gkv1199.

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Abstract Oxidation of a DNA thymine to 5-hydroxymethyluracil is one of several recently discovered epigenetic modifications. Here, we report the results of nanopore translocation experiments and molecular dynamics simulations that provide insight into the impact of this modification on the structure and dynamics of DNA. When transported through ultrathin solid-state nanopores, short DNA fragments containing thymine modifications were found to exhibit distinct, reproducible features in their transport characteristics that differentiate them from unmodified molecules. Molecular dynamics simulati
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Dissertations / Theses on the topic "Molecular Modifications"

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Pattarini, Lucia. "Post-translational modifications and molecular interactions regulating VEGFR2 activity." Doctoral thesis, Scuola Normale Superiore, 2009. http://hdl.handle.net/11384/85997.

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The work described in this thesis has been mainly focused on the study of a key molecule involved in blood vessel formation, the tyrosine kinase receptor VEGFR2. Considering that VEGFR2 biology should be tighly regulated to allow proper blood vessel formation and maintenance, we investigated two different mechanims influencing VEGFR2 activity: post translational modification and receptor complex formation. Since VEGFR2 biology is governed through protein modication, mainly phosphorylation, we decided to investigate the possible role of acetylation in VEGFR2 activity. Combining biochem
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Motleleng, Liabo Lilian. "Histone modifications and the Arabidopsis thaliana circadian clock." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/14719.

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Includes bibliographical references (leaves 61-84).<br>The circadian system has a regulatory role in almost all aspects of a plant's life. In Arabidopsis thaliana, almost 36% of the genome has been shown to be circadianly regulated and many genes that are circadianly regulated have been shown to be light responsive or involved in light responses. Rhythmic histone acetylation has been demonstrated in the promoter of TIMING OF CAB EXPRESSION1 (TOC1). Here, I used semi-quantitative Reverse Transcriptase Polymerase Chain Reaction (semi-quantitative RT -PCR) to investigate which enzymes are involve
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Zheng, Gang Gang Zheng. "A molecular 'switchboard' - lysine modifications and their impact on transcription." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1131636831.

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Zheng, Gang. "A MOLECULAR ‘SWITCHBOARD’-LYSINE MODIFICATIONS AND THEIR IMPACT ON TRANSCRIPTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1131636831.

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Baker, Daniel Lindley. "Relaxation dynamics in molecular glass-formers with systematic structure modifications." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/8734/.

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Glasses are amorphous materials which do not exhibit the long-range order or periodicity found in crystalline solids. A glass is formed by cooling a liquid at a sufficient rate such that crystallisation can be avoided. The structural disorder of glasses give them unique properties which make them suitable for a wide range of industrial, pharmaceutical or biological applications. Glass-forming materials generally exhibit several characteristic mechanisms of molecular motion. The physical origins and interrelation between these mechanisms are not well understood. In order to address this, detail
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Chen, Peng. "Function of wobble nucleoside modifications in tRNAs of Salmonella enterica Serovar Typhimurium." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-328.

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Transfer RNA from all organisms has modified nucleosides and position 34 (the wobble position) is one of the most extensively modified positions. Some wobble nucleoside modifications restrict codon choice (e.g. 5-methylaminomethyl-2-thiouridine, mnm5s2U) while some extend the decoding capacity (e.g. uridine-5-oxyacetic acid, cmo5U). In this thesis the influence of wobble nucleoside modification on cell physiology and translation efficiency and accuracy is described. A mutant proL tRNA (proL207) was isolated that had an unmodified adenosine in the wobble position. Surprisingly, the proL207 muta
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Coll, San Martín Laia. "Genetic disruption of transfer RNA modifications in human cancer." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672905.

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Cancer was reported as the second leading cause of death in 2018 by the World Health Organisation. Cancer is defined as the set of diseases that proceeds in multiple phases generating a transformation lead by an accumulation of genetic (mutations, copy number), epigenetic (CpG methylation, histone modifications), and epitranscriptomic alterations. Lung cancer is the primary cause of cancer-related deaths. It is commonly diagnosed at advanced stages, leading to a 5-year survival of about 21%. Lung cancer is historically subdivided according to resection specimens in small cell lung cancer (SCLC
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Hartsough, Edward J. "Molecular regulation of VEGFR-2 function and expression through post-translational modifications." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12417.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Vascular endothelial growth factor receptor-2 (VEGFR-2) is an endothelial cell receptor tyrosine kinase (RTK) whose activity is an obligate requirement for both normal development and pathological angiogenesis.
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Di, Antonio Marco. "New Molecular Devices for Selective Structural Modifications of G-Quadruplex Folded Oligonucleotides." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427493.

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The attention around selective recognition of G-Quadruplex has steadily grown during the past 10 years. G-4 are non-canonical DNA structures which can be generated from the self-assembling of guanine rich oligonucleotides. Such an interest is justified by the fact that it is widely recognized that the above structures could act as regulators of biological processes in vivo. In fact, there are several examples of G-Quadruplexes stabilization, by small molecules or engineered antibodies, which is translated into a strong influence of the biological process in which the oligonucleotide is involv
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Ali, Ibraheem Irfan. "Role of Post-translational Protein Modifications in Regulating HIV-1 and Mammalian Transcription." Thesis, University of California, San Francisco, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13423596.

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<p> The molecular gatekeepers of nearly all gene expression in living cells are the proteins that function in the process of transcription. Transcription occurs when a cell must respond to a signal. These signals can be in the form of metabolic responses, signals for growth or differentiation, signals to defend against stress or pathogenic invasion, to name a few. The fundamentals of transcription have been extensively studied in bacterial systems and model organisms, but technical limitations have hindered their studies in mammalian and human systems. Recent developments in mass spectrometric
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Books on the topic "Molecular Modifications"

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Geological Survey (U.S.), ed. Modifications of two palynological processing techniques: Ultrasonic processing and early-stage sieving. Dept. of the Interior, U.S. Geological Survey, 1992.

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1929-, Tsuboi Shōzō, Taniguchi Naoyuki 1942-, and Katunuma Nobuhiko 1926-, eds. The Post-translational modification of proteins: Roles in molecular and cellular biology. Japan Scientific Societies Press, 1992.

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Overweg, Arian. The preparation, modification and characterization of some molecular sieve materials. Eindhoven University, 1998.

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Henri, Grosjean, ed. DNA and RNA modification enzymes: Structure, mechanism, function, and evolution. Landes Bioscience, 2009.

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Blair, Mary Elizabeth. Habitat modification and gene flow in Saimiri oerstedii: Landscape genetics, intraspecific molecular systematics, and conservation. [publisher not identified], 2011.

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Susanne, Brakmann, and Johnsson Kai, eds. Directed molecular evolution of proteins: Or how to improve enzymes for biocatalysis. Wiley-VCH, 2002.

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Thor, G. Bioprocesses of biopharmaceuticals: The obligatory role of post translational modifications to create functional bioactive molecules. D&MD Publications, 2005.

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Zhou, Xiufen. Molecular genetic analysis of an unusual DNA modification and a phage defence system of streptomyces lividans 66. University of East Anglia, 1993.

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Lamond, Angus I. Pre-mRNA processing. Springer-Verlag, 1995.

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Lamond, Angus I. Pre-mRNA processing. R.G. Landes Co., 1995.

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Book chapters on the topic "Molecular Modifications"

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Carlberg, Carsten, Eunike Velleuer, and Ferdinand Molnár. "Histone Modifications." In Molecular Medicine. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-27133-5_7.

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Bross, Peter. "Posttranslational Modifications." In SpringerBriefs in Molecular Science. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-26088-4_11.

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Sivasudhan, Enakshi, Zhiliang Lu, Jia Meng, and Rong Rong. "RNA Modifications." In Handbook of Molecular Biotechnology. CRC Press, 2024. http://dx.doi.org/10.1201/9781003055211-20.

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Gait, Michael J., and Sudhir Agrawal. "Introduction and History of the Chemistry of Nucleic Acids Therapeutics." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_1.

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AbstractThis introduction charts the history of the development of the major chemical modifications that have influenced the development of nucleic acids therapeutics focusing in particular on antisense oligonucleotide analogues carrying modifications in the backbone and sugar. Brief mention is made of siRNA development and other applications that have by and large utilized the same modifications. We also point out the pitfalls of the use of nucleic acids as drugs, such as their unwanted interactions with pattern recognition receptors, which can be mitigated by chemical modification or used as
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Kong, Xiangli. "Molecular Structure of Starch." In Physical Modifications of Starch. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-5390-5_1.

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Abreu, Kristen, Yuxiang Li, and Jian Feng. "DNA Epigenetic Modifications." In Handbook of Molecular Biotechnology. CRC Press, 2024. http://dx.doi.org/10.1201/9781003055211-11.

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Cullen, Bryan R., and Kevin Tsai. "Mapping RNA Modifications Using Photo-Crosslinking-Assisted Modification Sequencing." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1374-0_8.

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Yu, Bin, and Xuemei Chen. "Analysis of miRNA Modifications." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-005-2_10.

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Lavitrano, Marialuisa, Laura Farina, Maria Grazia Cerrito, and Roberto Giovannoni. "Sperm-Mediated Genetic Modifications." In Methods in Molecular Biology. Springer US, 2019. http://dx.doi.org/10.1007/978-1-4939-9837-1_11.

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Treffon, Patrick, Michael Liebthal, Wilena Telman, and Karl-Josef Dietz. "Probing Posttranslational Redox Modifications." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7136-7_12.

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Conference papers on the topic "Molecular Modifications"

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Chen, Jiayi, Zhida Huang, Jingjing Li, Wei Zhang, Liang Zou, and Guan Wang. "Molecular Dynamics Simulation of Nano Modifications on Insulation Pressboard under Thermal Field." In 2024 IEEE 8th Conference on Energy Internet and Energy System Integration (EI2). IEEE, 2024. https://doi.org/10.1109/ei264398.2024.10990726.

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Stringer, John. "Materials for Fossil Energy Systems - Past, Present and Future." In CORROSION 1993. NACE International, 1993. https://doi.org/10.5006/c1993-93225.

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Abstract Fossil energy systems generate some 80% or more of the world’s energy. The vast majority of energy-generating systems are heat engines, which depend on the combustion of the fuel, and the recovery of the heat of combustion. The fossil fuels are coal, oil, and natural gas; and they may be directly combusted, or converted prior to combustion. The conversion of coal may be to a liquid fuel, or, more commonly, to a gaseous fuel; the crude oil may be converted to a lower molecular weight liquid, or again to a gaseous fuel. The natural gas may be converted, in some cases, to a liquid fuel.
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Agarwala, V. S., and S. Hettiarachchi. "Porphyrins and Phthalocyanines for Corrosion Inhibition." In CORROSION 1990. NACE International, 1990. https://doi.org/10.5006/c1990-90442.

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Abstract The electronic structure and the chemical properties of porphyrin and phthalocyanine molecules suggest that they are capable of strong chemisorption at metallic surfaces. Thus, a number of different porphyrins, phthalocyanines and their metallo- derivatives were synthesized and studied. The corrosion and electrochemical studies showed their excellent potential for corrosion inhibition. The current studies have shown that "tailor-making" the molecules through modification of chemical structure, could transform them into most efficient corrosion inhibitors. The degree of inhibidon impro
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Cha, Goeun, Jonghyeon Woo, Jeongsik Noh, and Jongsung Park. "Surface Modification of 3D Printed Biomedical Scaffolds Through an Electron Beam Processe." In 2024 IEEE 17th International Conference on Nano/Molecular Medicine & Engineering (NANOMED). IEEE, 2024. https://doi.org/10.1109/nanomed64244.2024.10946038.

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Chao, Chih-Ming, and Kerwin Wang. "Surface modifications for iron oxide nanoparticle assembly." In 2011 IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2011. http://dx.doi.org/10.1109/nems.2011.6017460.

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Hamlow, Lucas, J. Oomens, Giel Berden, et al. "STRUCTUAL EFFECTS OF CYTIDINE 2′ RIBOSE MODIFICATIONS AS DETERMINED BY IRMPD ACTION SPECTROSCOPY." In 70th International Symposium on Molecular Spectroscopy. University of Illinois at Urbana-Champaign, 2015. http://dx.doi.org/10.15278/isms.2015.mi13.

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Shao, Hao-Chiang. "UNVEILING VESTIGES OF MAN-MADE MODIFICATIONS ON MOLECULAR-BIOLOGICAL EXPERIMENT IMAGES." In 2018 IEEE Global Conference on Signal and Information Processing (GlobalSIP). IEEE, 2018. http://dx.doi.org/10.1109/globalsip.2018.8646594.

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Rothman, Laurence S. "The HITRAN Molecular Database: Enhancements for Remote Sensing." In Optical Remote Sensing of the Atmosphere. Optica Publishing Group, 1993. http://dx.doi.org/10.1364/orsa.1993.thc.1.

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Arčon, D., R. Blinc, P. Cevc, A. Omerzu, and D. Mihailovič. "Comparative study of ferromagnetic and non-ferromagnetic modifications of TDAE-." In ELECTRONIC PROPERTIES OF NOVEL MATERIALS--SCIENCE AND TECHNOLOGY OF MOLECULAR NANOSTRUCTURES. ASCE, 1999. http://dx.doi.org/10.1063/1.59814.

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Adamek, Maksimiljan. "Molecular Grammar of RNA-binding Protein Interactions in Formation and Function of Ribonucleoprotein Complexes." In Socratic Lectures 8. University of Lubljana Press, 2023. http://dx.doi.org/10.55295/psl.2023.ii15.

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Ribonucleoproteins (RNPs) are macromolecular assemblies of proteins along RNA molecules to carry out specialized cellular processes. Understanding how RNA binding proteins (RBPs) and RNA sequences determine the interactions to form RNPs and ultimately steer biomolecular processes remains poorly understood. There is a mounting evidence that RNP assembly de-pends on the formation of a network of transient, multivalent RBP RNA and RBP RBP interac-tions, particularly between tyrosine residues from intrinsically disordered domains and argi-nine residues from RNA-binding domains of RBPs. Furthermore
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Reports on the topic "Molecular Modifications"

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Library, Spring. Where Does Current Quorum Sensing Research Stand. Spring Library, 2020. http://dx.doi.org/10.47496/sl.blog.16.

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Quorum quenching is achieved by inactivating signalling enzymes, by introducing molecules that mimic signalling molecules and block their receptors, by degrading signalling molecules themselves, or by a modification of the quorum sensing signals due to an enzyme activity.
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Clough, S. B., S. Kumar, X. F. Sun, S. Tripathy, and H. Matsuda. Molecular and Crystal Engineering of Polydiacetylenes: Modification of Optical Properties. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/ada200808.

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López-Valverde, Nansi, Javier Aragoneses, Antonio López-Valverde, Cinthia Rodríguez, and Juan Manuel Aragoneses. Role in the osseointegration of titanium dental implants, of bioactive surfaces based on biomolecules: A systematic review and meta-analysis of in vivo studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0076.

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Review question / Objective: Does the bioactive surface of titanium dental implants, based on biomolecules, influence osseointegration?. The aim of our study was to evaluate the role and efficacy of bioactive surfaces in osseointegration. Our review study limited the research interest to titanium dental implants coated with a biomolecule, i.e., an organic molecule produced by a living organism. Condition being studied: In recent years, much attention has been paid to topographical modifications of dental implant surfaces, as well as to their coating with biologically active substances.a bioact
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Muyle, Aline. Analysis of DNA Methylation. Instats Inc., 2024. http://dx.doi.org/10.61700/6ayq8hff26qxn1470.

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This three-day workshop provides comprehensive training in the analysis of DNA methylation, a key epigenetic modification influencing gene expression and controlling the spread of transposable elements in genomes. Led by Dr Aline Muyle, participants will gain theoretical knowledge and practical skills in data preprocessing, statistical analysis, and visualization using RStudio and various bioinformatic software using Bash scripts. The workshop is suited for researchers in Biostatistics, Biology, Genetics, Ecology, Evolution, Bioinformatics, Molecular Biology, and Medical Research.
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Schaffer, Arthur, Jack Preiss, Marina Petreikov, and Ilan Levin. Increasing Starch Accumulation via Genetic Modification of the ADP-glucose Pyrophosphorylase. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7591740.bard.

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The overall objective of the research project was to utilize biochemical insights together with both classical and molecular genetic strategies to improve tomato starch accumulation. The proposal was based on the observation that the transient starch accumulation in the immature fruit serves as a reservoir for carbohydrate and soluble sugar content in the mature fruit, thereby impacting on fruit quality. The general objectives were to optimize AGPase function and activity in developing fruit in order to increase its transient starch levels. The specific research objectives were to: a) perform
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Porat, Ron, Gregory T. McCollum, Amnon Lers, and Charles L. Guy. Identification and characterization of genes involved in the acquisition of chilling tolerance in citrus fruit. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7587727.bard.

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Citrus, like many other tropical and subtropical fruit are sensitive to chilling temperatures. However, application of a pre-storage temperature conditioning (CD) treatment at 16°C for 7 d or of a hot water brushing (HWB) treatment at 60°C for 20 sec remarkably enhances chilling tolerance and reduces the development of chilling injuries (CI) upon storage at 5°C. In the current research, we proposed to identify and characterize grapefruit genes that are induced by CD, and may contribute to the acquisition of fruit chilling tolerance, by two different molecular approaches: cDNA array analysis an
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Anderson, Olin, Gad Galili, and Ann Blechl. Heterologous Expression of Wheat High Molecular Weight Glutenin Subunit Genes: Analysis and Modification of Protein Sequences Affecting Dough Quality. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7603826.bard.

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Brown Horowitz, Sigal, Eric L. Davis, and Axel Elling. Dissecting interactions between root-knot nematode effectors and lipid signaling involved in plant defense. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7598167.bard.

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Root-knot nematodes, Meloidogynespp., are extremely destructive pathogens with a cosmopolitan distribution and a host range that affects most crops. Safety and environmental concerns related to the toxicity of nematicides along with a lack of natural resistance sources threaten most crops in Israel and the U.S. This emphasizes the need to identify genes and signal mechanisms that could provide novel nematode control tactics and resistance breeding targets. The sedentary root-knot nematode (RKN) Meloidogynespp. secrete effectors in a spatial and temporal manner to interfere with and mimic multi
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Tzfira, Tzvi, Michael Elbaum, and Sharon Wolf. DNA transfer by Agrobacterium: a cooperative interaction of ssDNA, virulence proteins, and plant host factors. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7695881.bard.

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Agrobacteriumtumefaciensmediates genetic transformation of plants. The possibility of exchanging the natural genes for other DNA has led to Agrobacterium’s emergence as the primary vector for genetic modification of plants. The similarity among eukaryotic mechanisms of nuclear import also suggests use of its active elements as media for non-viral genetic therapy in animals. These considerations motivate the present study of the process that carries DNA of bacterial origin into the host nucleus. The infective pathway of Agrobacterium involves excision of a single-stranded DNA molecule (T-strand
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Weiss, David, and Neil Olszewski. Manipulation of GA Levels and GA Signal Transduction in Anthers to Generate Male Sterility. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7580678.bard.

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The original objectives of the research were: i. To study the role of GA in anther development, ii. To manipulate GA and/or GA signal transduction levels in the anthers in order to generate male sterility. iii. To characterize the GA signal transduction repressor, SPY. Previous studies have suggested that gibberellins (GAs) are required for normal anther development. In this work, we studied the role of GA in the regulation of anther development in petunia. When plants were treated with the GA-biosynthesis inhibitor paclobutrazol, anther development was arrested. Microscopic analysis of these
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