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Dissertations / Theses on the topic 'Molecular Modifications'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Pattarini, Lucia. "Post-translational modifications and molecular interactions regulating VEGFR2 activity." Doctoral thesis, Scuola Normale Superiore, 2009. http://hdl.handle.net/11384/85997.

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The work described in this thesis has been mainly focused on the study of a key molecule involved in blood vessel formation, the tyrosine kinase receptor VEGFR2. Considering that VEGFR2 biology should be tighly regulated to allow proper blood vessel formation and maintenance, we investigated two different mechanims influencing VEGFR2 activity: post translational modification and receptor complex formation. Since VEGFR2 biology is governed through protein modication, mainly phosphorylation, we decided to investigate the possible role of acetylation in VEGFR2 activity. Combining biochem

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2

Motleleng, Liabo Lilian. "Histone modifications and the Arabidopsis thaliana circadian clock." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/14719.

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Includes bibliographical references (leaves 61-84).<br>The circadian system has a regulatory role in almost all aspects of a plant's life. In Arabidopsis thaliana, almost 36% of the genome has been shown to be circadianly regulated and many genes that are circadianly regulated have been shown to be light responsive or involved in light responses. Rhythmic histone acetylation has been demonstrated in the promoter of TIMING OF CAB EXPRESSION1 (TOC1). Here, I used semi-quantitative Reverse Transcriptase Polymerase Chain Reaction (semi-quantitative RT -PCR) to investigate which enzymes are involve

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3

Zheng, Gang Gang Zheng. "A molecular 'switchboard' - lysine modifications and their impact on transcription." Connect to text online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1131636831.

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4

Zheng, Gang. "A MOLECULAR ‘SWITCHBOARD’-LYSINE MODIFICATIONS AND THEIR IMPACT ON TRANSCRIPTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1131636831.

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5

Baker, Daniel Lindley. "Relaxation dynamics in molecular glass-formers with systematic structure modifications." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/8734/.

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Glasses are amorphous materials which do not exhibit the long-range order or periodicity found in crystalline solids. A glass is formed by cooling a liquid at a sufficient rate such that crystallisation can be avoided. The structural disorder of glasses give them unique properties which make them suitable for a wide range of industrial, pharmaceutical or biological applications. Glass-forming materials generally exhibit several characteristic mechanisms of molecular motion. The physical origins and interrelation between these mechanisms are not well understood. In order to address this, detail

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6

Chen, Peng. "Function of wobble nucleoside modifications in tRNAs of Salmonella enterica Serovar Typhimurium." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-328.

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Transfer RNA from all organisms has modified nucleosides and position 34 (the wobble position) is one of the most extensively modified positions. Some wobble nucleoside modifications restrict codon choice (e.g. 5-methylaminomethyl-2-thiouridine, mnm5s2U) while some extend the decoding capacity (e.g. uridine-5-oxyacetic acid, cmo5U). In this thesis the influence of wobble nucleoside modification on cell physiology and translation efficiency and accuracy is described. A mutant proL tRNA (proL207) was isolated that had an unmodified adenosine in the wobble position. Surprisingly, the proL207 muta

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7

Coll, San Martín Laia. "Genetic disruption of transfer RNA modifications in human cancer." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672905.

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Cancer was reported as the second leading cause of death in 2018 by the World Health Organisation. Cancer is defined as the set of diseases that proceeds in multiple phases generating a transformation lead by an accumulation of genetic (mutations, copy number), epigenetic (CpG methylation, histone modifications), and epitranscriptomic alterations. Lung cancer is the primary cause of cancer-related deaths. It is commonly diagnosed at advanced stages, leading to a 5-year survival of about 21%. Lung cancer is historically subdivided according to resection specimens in small cell lung cancer (SCLC

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8

Hartsough, Edward J. "Molecular regulation of VEGFR-2 function and expression through post-translational modifications." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12417.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Vascular endothelial growth factor receptor-2 (VEGFR-2) is an endothelial cell receptor tyrosine kinase (RTK) whose activity is an obligate requirement for both normal development and pathological angiogenesis.

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9

Di, Antonio Marco. "New Molecular Devices for Selective Structural Modifications of G-Quadruplex Folded Oligonucleotides." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427493.

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The attention around selective recognition of G-Quadruplex has steadily grown during the past 10 years. G-4 are non-canonical DNA structures which can be generated from the self-assembling of guanine rich oligonucleotides. Such an interest is justified by the fact that it is widely recognized that the above structures could act as regulators of biological processes in vivo. In fact, there are several examples of G-Quadruplexes stabilization, by small molecules or engineered antibodies, which is translated into a strong influence of the biological process in which the oligonucleotide is involv

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10

Ali, Ibraheem Irfan. "Role of Post-translational Protein Modifications in Regulating HIV-1 and Mammalian Transcription." Thesis, University of California, San Francisco, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13423596.

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<p> The molecular gatekeepers of nearly all gene expression in living cells are the proteins that function in the process of transcription. Transcription occurs when a cell must respond to a signal. These signals can be in the form of metabolic responses, signals for growth or differentiation, signals to defend against stress or pathogenic invasion, to name a few. The fundamentals of transcription have been extensively studied in bacterial systems and model organisms, but technical limitations have hindered their studies in mammalian and human systems. Recent developments in mass spectrometric

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11

Morielli, Tania. "Reactive oxygen species promote redox-dependent protein modifications and impair motility and capacitation in human spermatozoa." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121343.

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Oxidative stress, generated by excessive reactive oxygen species (ROS) and/or decrease in antioxidant defences, is associated with male infertility. A consequence of oxidative stress is the generation of excessive redox dependent protein modifications, such as tyrosine nitration (Nitro-Y) and S-glutathionylation (GSS-R). We hypothesize that excessive Nitro-Y and GSS-R levels impair sperm motility and capacitation (process by which sperm gain fertilizing ability). The aims of this study were to determine: 1) the effect of different ROS on motility, capacitation and the production of Nitro-Y and

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12

Durbin, Ann M. "Nucleotide Modifications of RNA Suppress RIG-I Antiviral Signaling by Unique Mechanisms." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493466.

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In order to counter pathogen infection while preventing autoimmune responses, the human innate immune system must be precisely regulated to distinguish “self” from “non-self”. Pattern recognition receptors detect “non-self” pathogen RNAs and initiate antiviral signaling. Accumulated evidence suggests that host “self” RNAs contain modified nucleotides that evade or suppress immune signaling; however, the precise mechanisms are not understood. Defining these mechanisms is relevant toward understanding the biology of immunity as well as the applied use of RNAs as therapeutic molecules, where redu

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13

Liu, Ling, and 刘凌. "Regulation of post-translational modifications of the protein kinase LKB1: molecular mechanisms and physiologicalimplications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47660831.

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Background and objectives: Endothelial dysfunction and cancer are two of the important aspects of obesity-related medical complications, the prevalence of which is reaching an epidemic level worldwide. The protein kinase LKB1 has been shown to play opposite roles in these two metabolic diseases by promoting cellular senescence and inhibiting cell proliferation through regulating a series of its downstream targets. However, the molecular mechanisms wherebyLKB1 itself is regulated by its upstream molecules remains poorly understood. The major objectives of this study are to identify novel u

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14

To, Kar-wing. "Molecular modifications and functional conditioning of dendritic cells (DC) for DC-based tumor vaccines." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38860144.

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15

To, Kar-wing, and 杜嘉詠. "Molecular modifications and functional conditioning of dendritic cells(DC) for DC-based tumor vaccines." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38860144.

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16

Musolino, Nicholas J. "Molecular design of interfacial modifications to alter adsorption/desorption equilibria at fluid-adjoining interfaces." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/79206.

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Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2013.<br>"February 2013." Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 151-168).<br>The thermodynamics and mass transfer kinetics of adsorption and desporption at interfaces play vital roles in chemical analysis, separation processes, and many natural phenomena. In this work, computer simulations were used to design interfacial modifications to alter the physical processes of adsorption and desorption, using two different approaches to molecular design. In the fir

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17

Balliu, Aleksandra. "Exploring molecular interactions between polypeptide conjugates and protein targets : Manipulating affinity by chemical modifications." Doctoral thesis, Uppsala universitet, Organisk kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327121.

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In this thesis molecular interactions between polypeptide conjugates and protein targets were investigated. Polypeptides were derivatized with small organic molecules, peptides and oligonucleotides. New strategies were developed with the aim to increase affinities for proteins of biological interest. A 42-residue polypeptide (4-C15L8) conjugated to a small organic molecule 3,5-bis[[bis(2-pyridylmethyl)amino]methyl]benzoic acid (PP1), was shown to bind glycogen phosphorylase a (GPa) in the presence of zinc ions. Under the assumption that hydrophobic interactions dominated the binding energy, th

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18

Esberg, Anders. "Functional aspects of wobble uridine modifications in yeast tRNA." Doctoral thesis, Umeå : Department of Molecular Biology, Umeå Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1093.

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19

Chen, Ye Grace. "The Discovery and Characterization of NAD-Linked RNA." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10447.

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Over the past few decades, RNA has emerged as much more than just an intermediary in biology’s central dogma. RNA is now known to play a variety of catalytic, regulatory and defensive roles in living systems as demonstrated through the discoveries of ribozymes, riboswitches, microRNAs, small interfering RNAs, Piwi-interacting RNAs, small nuclear RNAs, clusters of regularly interspaced short palindromic repeat RNAs and long non-coding RNAs. In contrast to the functional diversity of RNA, the chemical diversity has remained primarily limited to canonical polyribonucleotides, the 5’ cap on mRNAs

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20

Zhang, Jinchao. "FUNCTIONAL ROLES FOR POST-TRANSLATIONAL MODIFICATIONS OF t-SNARES IN PLATELETS." UKnowledge, 2016. http://uknowledge.uky.edu/biochem_etds/26.

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Platelets affect vascular integrity by secreting a host of molecules that promote hemostasis and its sequela. Given its importance, it is critical to understand how platelet exocytosis is controlled. Post-translational modifications, such as phosphorylation and acylation, have been shown to affect signaling pathways and platelet function. In this dissertation, I focus on how these modifications affect the t-SNARE proteins, SNAP-23 and syntaxin-11, which are both required for platelet secretion. SNAP-23 is regulated by phosphorylation. Using a proteoliposome fusion assay, I demonstrate that pur

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21

Howe, Françoise Sara. "Crosstalk between histone modifications in Saccharomyces cerevisiae." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:1e2e128e-1ec3-4d41-8ab5-b27e5930a654.

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The N-terminal tails of histone proteins protrude from the nucleosome core and are extensively post-translationally modified. These modifications are proposed to affect many DNA-based processes such as transcription, DNA replication and repair. Post-translational modifications on histone tails do not act independently but are subject to crosstalk. One example of crosstalk is on histone H3 between lysine 14 (H3K14) and trimethylated lysine 4 (H3K4me3), a modification found at the 5’ end of most active or poised genes. In this work, Western blots and chromatin immunoprecipitation (ChIP) experime

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22

Goode, Derek. "The effect of surface charge modifications on the molecular structure and stability of #gamma# crystallins." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385532.

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23

Chou, Hsin-Jung. "Transcriptome-Wide Analysis of Roles for Transfer RNA Modifications in Translational Regulation." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/943.

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Covalent nucleotide modifications in RNAs affect numerous biological processes, and novel functions are continually being revealed even for well-known modifications. Among all RNA species, transfer RNAs (tRNAs) are highly enriched with diverse modifications, which are known to play roles in decoding and tRNA stability, charging, and cellular trafficking. However, studies of tRNA modifications have been limited in a small scale and performed by groups with different methodologies. To systematically compare the functions of a large set of noncoding RNA modifications in translational regulation,

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24

Delandre, Caroline. "Investigating post-translational modifications of Tetraspanins : palmitoylation of CD81 and glycosylation of Tspan-2." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/1527.

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25

Ghanta, Krishna S. "An Exploration of the Properties of Repair Template DNA that Promote Precision Genome Editing." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1150.

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CRISPR/Cas9 induced DNA breaks can be precisely repaired by cellular homology-directed repair (HDR) pathways using exogenously provided template DNA (donor). However, the full potential of precision editing is hindered in many model systems by low cutting efficiencies, low HDR efficiencies and, cytotoxicity related to Cas9 and donor DNA. In this thesis, I address these challenges and present methods that we developed to increase HDR efficiencies in multiple model organisms. In Caenorhabditis elegans, we show that by reducing toxicity high editing efficiencies can be achieved with single strand

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26

McMichael, Temet M. "Posttranslational modifications and virus restriction activity of IFITM3." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531146508041228.

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27

Viéitez, Manrique Cristina 1984. "The Role of histone modifications in transcriptional regulation upon stress." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/382837.

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In response to fluctuations in the environment, all living organisms have the ability to sense, respond and adapt to the new conditions. In budding yeast (Saccharomyces cerevisiae) there is a massive and rapid reorganization of the transcriptional program in response to a stressful situation, which is governed by different signaling pathways, transcription factors, chromatin remodelers and histone modifiers. Many examples of histone posttranslational modifications (PTM) have been associated with transcriptional activation or repression under normal growth conditions, however little is known ab

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Felician, Giulia. "Regulation of Notch signaling in the heart by epigenetic modifications." Doctoral thesis, Scuola Normale Superiore, 2015. http://hdl.handle.net/11384/85955.

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Synopsis: Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life is of paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac damage. The Notch pathway plays a key role in the regulation of cardiomyocyte proliferation during mammalian embryonic life. Moreover, it is essentially involved in the cardiac regeneration process after injury in Zebrafish. Therefore, we assessed the efficacy of Notch pathway activation to sustain cardiac regeneration in a model of myocard

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Huang, Bo. "Formation and function of wobble uridine modifications in transfer RNA of Saccharomyces cerevisiae." Doctoral thesis, Umeå : Department of Molecular Biology (Faculty of Science and Technology), Umeå Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1433.

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30

Mateos, Mickaël. "Modifications électrochimiques de surfaces et dispositifs électroniques organiques." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCK039/document.

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L’électronique organique reste un domaine de recherche prolifique grâce à la diversité de structures moléculaires accessible par la synthèse organique. Les matériaux moléculaires offrent des possibilités de mises en forme inédites comme les techniques de dépôt en solution, utilisables dans la conception de dispositifs organiques sur supports plastiques. Nos travaux de recherche mêlent électrochimie, conception et caractérisations électriques de dispositifs et mesures capteur. Ils abordent deux thématiques : l’élaboration de nouveaux transducteurs à base de polyanilines substituées et de phtalo

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31

Carvalho, Mariana Francisca Simões. "Fotoenvelhecimento da pele: fisiopatologia molecular e prevenção." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4515.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A pele sofre modificações morfológicas e fisiológicas com o avançar do tempo que podem ser causadas por fatores extrínsecos ao organismo, tais como a exposição à radiação solar, poluição do ar e hábitos tabágicos, e fatores intrínsecos de natureza genómica, bioquímica e celular. Coletivamente, estes fatores contribuem para envelhecimento celular e organismal, incluindo o envelhecimento da pele, podendo também desempenhar um

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32

Atnagulov, Aydar. "Application of Mass Spectrometry to the Characterization of Core and Ligand Shell Modifications of Silver Molecular Nanoparticles." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501860803445199.

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33

Tridico, Silvana. "Morphological and molecular approaches to characterise modifications relating to mammalian hairs in archaeological, paleontological and forensic contexts." Thesis, Tridico, Silvana (2015) Morphological and molecular approaches to characterise modifications relating to mammalian hairs in archaeological, paleontological and forensic contexts. PhD thesis, Murdoch University, 2015. https://researchrepository.murdoch.edu.au/id/eprint/28852/.

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Mammalian hair is readily shed and transferred to persons or objects during contact; this property renders hair as one of the most ubiquitous and prevalent evidence type encountered in forensic investigations and at ancient burial sites. The durability and stability of hair ensures their survival for millennia; their status as a privileged repository of viable genetic material consolidates their value as a biological substrate. The aims of this thesis are to showcase the wealth, and breadth, of information that may be gleaned from these unique structures and address the current problem regardi

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Näsvall, Joakim. "Wobble modifications and other features in transfer RNA important for decoding and reading frame maintenance." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknisk-naturvetenskaplig fakultet), 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1399.

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Transfer RNA (tRNA) is the adaptor molecule responsible for bringing the correct amino acid to the ribosome during protein synthesis. tRNA contains a number of modified nucleosides, which are derivatives of the four normal nucleosides. A great variety of modifications are found in the anticodon loop, especially at the first (wobble) position of the anticodon. According to Crick’s wobble hypothesis, a uridine at the wobble position of tRNA recognize codons ending with A and G. Uridine-5-oxyacetic acid (cmo5U34), found at the wobble position of six species of tRNA in Salmonella enterica, have be

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Schweighoffer, Fabien. "Modifications de l'expression genetique au cours du developpement musculaire in vivo chez le rat." Paris 6, 1986. http://www.theses.fr/1986PA066093.

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Lönn, Peter. "Regulation of TGF-β Signaling by Post-Translational Modifications". Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128855.

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Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. Enhancement or repression of Smad-specific gene targets leads to intracellular protein compositions which organize functional complexes and thus govern cellular processes such as proliferation, migration and differentiation. TGF-β/Smad signaling relays are regulated by various post-translational m

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Rin, Ketsugi. "The suppression of p53 function due to viral infection & the molecular mechanism of p53 post-translational modifications." 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147928.

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Das, Sadhan Chandra. "Molecular mechanism of nucleolin-mediated Pol I transcription and characterization of nucleolin acetylation." Thesis, Lyon, École normale supérieure, 2012. http://www.theses.fr/2012ENSL0767.

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Nous montrons dans cette étude que dans les cellules déplétées pour la nucléoline, une plus faible accumulation de pré-ARNr est associée à une augmentation de marques d’hétérochromatine (H3K9me2) et une diminution de marques d’euchromatine (H4K12ac et H3K4me3) sur la chromatine des gènes ribosomiques. Des expériences de ChIP-seq montrent que la nucléoline est enrichie dans la région codante et promotrice de l’ADNr et est préférentiellement associée avec les gènes non méthylés des ARNr. La déplétion de la nucléoline entraîne une accumulation de l’ARN Pol I au début de l’ADNr et une diminution d

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Kriss, Crystina Leah. "Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics." Scholar Commons, 2018. http://scholarcommons.usf.edu/etd/7185.

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Alcohol liver disease (ALD) is a major health concern throughout the world. Currently, in the United States, 17 million people suffer from alcoholism, of which 1.4 million people are receiving treatment [1, 2]. The link between ethanol metabolism, reactive oxygen species (ROS) and liver injury in ALD has been well characterized over the last couple decades [3-10]. Ethanol metabolism relies on the availability of the cofactor NAD+ for the oxidation of ethanol into acetate, consequently causing alterations in redox potential. Redox dysfunction within the mitochondria can affect multiple path

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López, Ramos Rita. "Linker histone post-translational modifications and effects of phosphorylation on secondary structure and chromatin aggregation." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/131313.

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Les histones linker juguen un paper important en l’organització i manteniment de la cromatina en estructures d'ordre superior i en la regulació transcripcional. La histona H1 en vertebrats té una estructura característica en tres dominis: un domini N-terminal curt i flexible; un domini globular central; i un domini C-terminal llarg. Els dominis N- i C-terminals (CTD) són molt bàsics i es troben desestructurats en solució aquosa. La distribució de càrrega és bastant uniforme al llarg de tot el CTD. La interacció amb el DNA indueix un plegament total i estable del CTD en condicions fisiològiques

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Liao, Chen-Ting, Xuan Li, Daniel J. Haxton, et al. "Probing autoionizing states of molecular oxygen with XUV transient absorption: Electronic-symmetry-dependent line shapes and laser-induced modifications." AMER PHYSICAL SOC, 2017. http://hdl.handle.net/10150/624049.

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We used extreme ultraviolet (XUV) transient absorption spectroscopy to study the autoionizing Rydberg states of oxygen in an electronically- and vibrationally-resolved fashion. XUVpulse initiates molecular polarization and near-infrared pulse perturbs its evolution. Transient absorption spectra show positive optical-density (OD) change in the case of ns sigma(g) and nd pi(g) autoionizing states of oxygen and negative OD change for nd sigma(g) states. Multiconfiguration time-dependent Hartree-Fock (MCTDHF) calculations are used to simulate the transient absorption and the resulting spectra and

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Bighinati, Andrea <1988&gt. "A preclinical study of spinal cord injury focused on cellular and molecular modifications as potential targets for innovative therapies." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9683/1/Tesi%20di%20dottorato_Bighinati_Approvedfinal.pdf.

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Spinal Cord Injury (SCI) is a devastating condition for human and animal health. In SCI particularly, neurons, oligodendrocytes precursor cells, and mature oligodendrocytes are highly vulnerable to the toxic microenvironment after the lesion and susceptible to the elevated levels of noxious stimuli. Thus the regenerative response of the organism in case of SCI is significantly reduced, and only little spontaneous amelioration is observed in lesioned patients during the early phases. This work mainly focuses on studying and characterizing the modification induced by the SCI in a preclinical a

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Hsieh, Tsung-Han S. "Three-dimensional Folding of Eukaryotic Genomes." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/903.

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Chromatin packages eukaryotic genomes via a hierarchical series of folding steps, encrypting multiple layers of epigenetic information, which are capable of regulating nuclear transactions in response to complex signals in environment. Besides the 1-dimensinal chromatin landscape such as nucleosome positioning and histone modifications, little is known about the secondary chromatin structures and their functional consequences related to transcriptional regulation and DNA replication. The family of chromosomal conformation capture (3C) assays has revolutionized our understanding of large-scale

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Hsieh, Tsung-Han S. "Three-dimensional Folding of Eukaryotic Genomes." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/903.

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Chromatin packages eukaryotic genomes via a hierarchical series of folding steps, encrypting multiple layers of epigenetic information, which are capable of regulating nuclear transactions in response to complex signals in environment. Besides the 1-dimensinal chromatin landscape such as nucleosome positioning and histone modifications, little is known about the secondary chromatin structures and their functional consequences related to transcriptional regulation and DNA replication. The family of chromosomal conformation capture (3C) assays has revolutionized our understanding of large-scale

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Nasu, Daichi [Verfasser], Harald [Akademischer Betreuer] Kolmar, and Gerd [Akademischer Betreuer] Buntkowsky. "Non-Natural Elements for Peptide-Based Molecular Design, Structural Analysis, and Functional Modifications / Daichi Nasu. Betreuer: Harald Kolmar ; Gerd Buntkowsky." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2016. http://d-nb.info/1112044949/34.

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Lercher, Lukas A. "Chemical tools for the study of epigenetic mechanisms." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8fec2af6-573b-464a-865e-a70d31fa1c41.

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The overall goal of my work was to develop and apply new chemical methods for the study of epigenetic DNA and protein modifications. In Chapter 3 the development of Suzuki-Miyaura cross coupling (SMcc) for the post-synthetic modification of DNA is described. DNA modification by SMcc is efficient (4-6h) and proceeds under mild conditions (37°C, pH 8.5). The incorporation of various groups useful for biological investigations is demonstrated using this methodology. Using a photocrosslinker, introduced into the DNA by SMcc capture experiments are performed to identify potential binding partners o

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CHETOUANI, FARID. "Developpement d'un logiciel d'edition/analyse de la structure secondaire des arns - recherche informatique de motifs arns structures et d'enzymes de modifications de nucleotides." Toulouse 3, 1999. http://www.theses.fr/1999TOU30011.

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La biogenese des ribosomes se deroule dans un compartiment nucleaire dedie, le nucleole, ou l'arn preribosomique subit de nombreux decoupages et modifications de nucleotides impliquant l'intervention d'un grand nombre de petits arns (snoarns). Les sites des modifications de nucleotides les plus frequentes dans l'arnr (methylations en 2-o du ribose et pseudouridylations) sont specifies par l'appariement au pre-arnr de deux familles distinctes de snoarns, qui forment une structure en duplex reconnue par une enzyme specifique de chaque type de modification. Pour assister le biologiste dans l'anal

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Cacabelos, Barral Daniel. "Polyunsaturated fatty acids in amyotrophic lateral sclerosis: role of DHA, peroxidative modifications and sexual dimorphism." Doctoral thesis, Universitat de Lleida, 2014. http://hdl.handle.net/10803/285530.

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In the present work we focus into the potential relevance of PUFAs in some models and human samples from patients suffering amyotrophic lateral sclerosis (ALS). Due to its pathological implication, oxidative stress was our first goal. We started from simple oxidative methodology screening to search for an antioxidant substance (among 21 different candidates) available in a Mediterranean diet. The results demonstrated high heterogeneity in carbonyl (measured by DNP) accumulation, regarding the oxidative source, substrate suffering it and the antioxidant structure. Further, thanks to GC/MS

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Rajput, Abdul Mateen. "Histone modifications after DNA damage affect survival in Schizosaccharomyces pombe." Thesis, Södertörns högskola, Institutionen för livsvetenskaper, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-6886.

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S. cerevisiae Ada2 and Bre1 has a role in histone post-translational modifications. Deletion of these genes causes deficiency in acetylation (Ada2) or ubiquitination (Bre1) of histones. Further, mutants lacking these genes or homologous genes showed different phenotypes in human and S. cerevisiae while treated with DNA damaging agents 4-NQO and MMS. Bre1 deficient cells showed 4-NQO sensitivity in S. cerevisiae and resistance in human cells. Since it has been shown that S. pombe is more close to mammals in chromatin regulation we wanted to examine S. pombe response against MMS and 4-NQO. By ho

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Matlock, Ashanti Ochumare. "Catalytic and Biological Implications of The Eukaryotic and Prokaryotic Thg1 Enzyme Family." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555598687105069.

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