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Journal articles on the topic 'Molecular motors'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kassem, Salma, Thomas van Leeuwen, Anouk S. Lubbe, Miriam R. Wilson, Ben L. Feringa, and David A. Leigh. "Artificial molecular motors." Chemical Society Reviews 46, no. 9 (2017): 2592–621. http://dx.doi.org/10.1039/c7cs00245a.

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Artificial molecular motors take inspiration from motor proteins, nature's solution for achieving directional molecular level motion. An overview is given of the principal designs of artificial molecular motors and their modes of operation. We identify some key challenges remaining in the field.

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2

KLUMPP, STEFAN, MELANIE J. I. MÜLLER, and REINHARD LIPOWSKY. "COOPERATIVE TRANSPORT BY SMALL TEAMS OF MOLECULAR MOTORS." Biophysical Reviews and Letters 01, no. 04 (2006): 353–61. http://dx.doi.org/10.1142/s1793048006000288.

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Molecular motors power directed transport of cargoes within cells. Even if a single motor is sufficient to transport a cargo, motors often cooperate in small teams. We discuss the cooperative cargo transport by several motors theoretically and explore some of its properties. In particular we emphasize how motor teams can drag cargoes through a viscous environment.

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3

NI, CHEN, and JUN-ZHONG WANG. "STM STUDIES ON MOLECULAR ROTORS AND MOTORS." Surface Review and Letters 25, Supp01 (2018): 1841004. http://dx.doi.org/10.1142/s0218625x18410044.

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Molecular motor is a nanoscale machine that consumes energy to produce work via the unidirectional and controlled movement. They are universal in nature and essential to numerous processes of life. When mounted onto solid surfaces, scanning tunneling microscopy (STM) is a powerful technique to characterize the molecular rotors and motors due to the atomic-scale resolution coupled with its ability to track the motion of molecular rotor and motor over time. Moreover, the molecular rotors and motors can be powered by STM tip through injecting tunneling electrons. This review addresses recent adva

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4

Schliwa, Manfred, and Günther Woehlke. "Molecular motors." Nature 422, no. 6933 (2003): 759–65. http://dx.doi.org/10.1038/nature01601.

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5

Trybus, Kathleen M., and Vladimir I. Gelfand. "Molecular motors." Molecular Biology of the Cell 24, no. 6 (2013): 672. http://dx.doi.org/10.1091/mbc.e12-12-0873.

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6

Cross, R. A., and N. J. Carter. "Molecular motors." Current Biology 10, no. 5 (2000): R177—R179. http://dx.doi.org/10.1016/s0960-9822(00)00368-7.

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7

Berger, Florian, Corina Keller, Melanie J. I. Müller, Stefan Klumpp, and Reinhard Lipowsky. "Co-operative transport by molecular motors." Biochemical Society Transactions 39, no. 5 (2011): 1211–15. http://dx.doi.org/10.1042/bst0391211.

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Intracellular transport is often driven co-operatively by several molecular motors, which may belong to one or several motor species. Understanding how these motors interact and what co-ordinates and regulates their movements is a central problem in studies of intracellular transport. A general theoretical framework for the analysis of such transport processes is described, which enables us to explain the behaviour of intracellular cargos by the transport properties of individual motors and their interactions. We review recent advances in the theoretical description of motor co-operativity and

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8

Spector, Alexander A. "Effectiveness, Active Energy Produced by Molecular Motors, and Nonlinear Capacitance of the Cochlear Outer Hair Cell." Journal of Biomechanical Engineering 127, no. 3 (2005): 391–99. http://dx.doi.org/10.1115/1.1894233.

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Cochlear outer hair cells are crucial for active hearing. These cells have a unique form of motility, named electromotility, whose main features are the cell’s length changes, active force production, and nonlinear capacitance. The molecular motor, prestin, that drives outer hair cell electromotility has recently been identified. We reveal relationships between the active energy produced by the outer hair cell molecular motors, motor effectiveness, and the capacitive properties of the cell membrane. We quantitatively characterize these relationships by introducing three characteristics: effect

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9

Endow, S. A. "Molecular motors--a paradigm for mutant analysis." Journal of Cell Science 113, no. 8 (2000): 1311–18. http://dx.doi.org/10.1242/jcs.113.8.1311.

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Molecular motors perform essential functions in the cell and have the potential to provide insights into the basis of many important processes. A unique property of molecular motors is their ability to convert energy from ATP hydrolysis into work, enabling the motors to bind to and move along cytoskeletal filaments. The mechanism of energy conversion by molecular motors is not yet understood and may lead to the discovery of new biophysical principles. Mutant analysis could provide valuable information, but it is not obvious how to obtain mutants that are informative for study. The analysis pre

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10

Pooler, Daisy R. S., Anouk S. Lubbe, Stefano Crespi, and Ben L. Feringa. "Designing light-driven rotary molecular motors." Chemical Science 12, no. 45 (2021): 14964–86. http://dx.doi.org/10.1039/d1sc04781g.

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Various families of light-driven rotary molecular motors and the key aspects of motor design are discussed. Comparisons are made between the strengths and weaknesses of each motor. Challenges, applications, and future prospects are explored.

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11

Lin, Tsai-Shun, and Chien-Jung Lo. "2P154 Investigating stators assembly of flagellar motors in Escherichia coli(11. Molecular motor,Poster)." Seibutsu Butsuri 53, supplement1-2 (2013): S184. http://dx.doi.org/10.2142/biophys.53.s184_4.

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12

Rueangkham, Naruemon, Miguel Valle-Inclán Cabello, Franziska Lautenschläger, and Rhoda J. Hawkins. "Nuclear deformation by microtubule molecular motors." PLOS Computational Biology 21, no. 5 (2025): e1012305. https://doi.org/10.1371/journal.pcbi.1012305.

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We present a model to calculate the displacement and extension of deformable cellular cargo pulled by molecular motors stepping along cytoskeletal filaments. We consider the case of a single type of molecular motor and cytoskeletal filaments oriented in one dimension in opposite directions on either side of a cargo. We model a deformable cargo as a simple elastic spring. We simulate this tug-of-war simple exclusion process model using a Monte Carlo Gillespie algorithm and calculate the displacement and extension of the cargo for different configurations of motors and filaments. We apply our mo

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13

Kistemaker, Jos C. M., Anouk S. Lubbe, and Ben L. Feringa. "Exploring molecular motors." Materials Chemistry Frontiers 5, no. 7 (2021): 2900–2906. http://dx.doi.org/10.1039/d0qm01091j.

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The introduction of mechanical functions and controlled motion based on molecular motors and machines offers tremendous opportunities towards the design of dynamic molecular systems and responsive materials.

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14

Jülicher, Frank, Armand Ajdari, and Jacques Prost. "Modeling molecular motors." Reviews of Modern Physics 69, no. 4 (1997): 1269–82. http://dx.doi.org/10.1103/revmodphys.69.1269.

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15

Molloy, J. E., and C. Veigel. "Editorial: Molecular motors." IEE Proceedings - Nanobiotechnology 150, no. 3 (2003): 93. http://dx.doi.org/10.1049/ip-nbt:20031216.

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16

Iino, Ryota, Kazushi Kinbara, and Zev Bryant. "Introduction: Molecular Motors." Chemical Reviews 120, no. 1 (2020): 1–4. http://dx.doi.org/10.1021/acs.chemrev.9b00819.

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17

Davis, Anthony P. "Synthetic molecular motors." Nature 401, no. 6749 (1999): 120–21. http://dx.doi.org/10.1038/43576.

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18

Magnasco, Marcelo O. "Molecular combustion motors." Physical Review Letters 72, no. 16 (1994): 2656–59. http://dx.doi.org/10.1103/physrevlett.72.2656.

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19

Jülicher, Frank, and Jacques Prost. "Cooperative Molecular Motors." Physical Review Letters 75, no. 13 (1995): 2618–21. http://dx.doi.org/10.1103/physrevlett.75.2618.

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20

Soppina, Virupakshi, and Kristen J. Verhey. "The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors." Molecular Biology of the Cell 25, no. 14 (2014): 2161–70. http://dx.doi.org/10.1091/mbc.e14-01-0696.

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The kinesin-3 family (KIF) is one of the largest among the kinesin superfamily and an important driver of a variety of cellular transport events. Whereas all kinesins contain the highly conserved kinesin motor domain, different families have evolved unique motor features that enable different mechanical and functional outputs. A defining feature of kinesin-3 motors is the presence of a positively charged insert, the K-loop, in loop 12 of their motor domains. However, the mechanical and functional output of the K-loop with respect to processive motility of dimeric kinesin-3 motors is unknown. W

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21

Bakewell, David J. G., and Dan V. Nicolau. "Protein Linear Molecular Motor-Powered Nanodevices." Australian Journal of Chemistry 60, no. 5 (2007): 314. http://dx.doi.org/10.1071/ch06456.

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Myosin–actin and kinesin–microtubule linear protein motor systems and their application in hybrid nanodevices are reviewed. Research during the past several decades has provided a wealth of understanding about the fundamentals of protein motors that continues to be pursued. It has also laid the foundations for a new branch of investigation that considers the application of these motors as key functional elements in laboratory-on-a-chip and other micro/nanodevices. Current models of myosin and kinesin motors are introduced and the effects of motility assay parameters, including temperature, tox

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22

LIPOWSKY, REINHARD, JANINA BEEG, RUMIANA DIMOVA, et al. "ACTIVE BIO-SYSTEMS: FROM SINGLE MOTOR MOLECULES TO COOPERATIVE CARGO TRANSPORT." Biophysical Reviews and Letters 04, no. 01n02 (2009): 77–137. http://dx.doi.org/10.1142/s1793048009000946.

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Living cells contain a large number of molecular motors that convert the chemical energy released from nucleotide hydrolysis into mechanical work. This review focusses on stepping motors that move along cytoskeletal filaments. The behavior of these motors involves three distinct nonequilibrium processes that cover a wide range of length and time scales: (i) Directed stepping of single motors bound to a filament; (ii) Composite motor walks of single motors consisting of directed stepping interrupted by diffusive motion; and (iii) Cooperative transport by teams of several motors. On the molecula

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23

Feizabadi, Mitra Shojania, Ramiz S. Alejilat, Alexis B. Duffy, Jane C. Breslin, and Ibukunoluwa I. Akintola. "A Confirmation for the Positive Electric Charge of Bio-Molecular Motors through Utilizing a Novel Nano-Technology Approach In Vitro." International Journal of Molecular Sciences 21, no. 14 (2020): 4935. http://dx.doi.org/10.3390/ijms21144935.

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Molecular motors are microtubule-based proteins which contribute to many cell functions, such as intracellular transportation and cell division. The details of the nature of the mutual interactions between motors and microtubules still needs to be extensively explored. However, electrostatic interaction is known as one of the key factors making motor-microtubule association possible. The association rate of molecular motors to microtubules is a way to observe and evaluate the charge of the bio-motors in vivo. Growing evidence indicates that microtubules with distinct structural compositions in

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24

Zhang, Long, Yunyan Qiu, Wei-Guang Liu, et al. "An electric molecular motor." Nature 613, no. 7943 (2023): 280–86. http://dx.doi.org/10.1038/s41586-022-05421-6.

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AbstractMacroscopic electric motors continue to have a large impact on almost every aspect of modern society. Consequently, the effort towards developing molecular motors1–3 that can be driven by electricity could not be more timely. Here we describe an electric molecular motor based on a [3]catenane4,5, in which two cyclobis(paraquat-p-phenylene)6 (CBPQT4+) rings are powered by electricity in solution to circumrotate unidirectionally around a 50-membered loop. The constitution of the loop ensures that both rings undergo highly (85%) unidirectional movement under the guidance of a flashing ene

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25

Esaki, Seiji, Yoshiharu Ishii, and Toshio Yanagida. "1P273 Cooperativity causes plasticity in molecular motors(9. Molecular motor (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)." Seibutsu Butsuri 46, supplement2 (2006): S215. http://dx.doi.org/10.2142/biophys.46.s215_1.

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26

Feng, Mudong, and Michael K. Gilson. "Mechanistic analysis of light-driven overcrowded alkene-based molecular motors by multiscale molecular simulations." Physical Chemistry Chemical Physics 23, no. 14 (2021): 8525–40. http://dx.doi.org/10.1039/d0cp06685k.

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Ground-state and excited-state molecular dynamics simulations shed light on the rotation mechanism of small, light-driven molecular motors and predict motor performance. How fast can they rotate; how much torque and power can they generate?

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27

Feng, Yuanning, Marco Ovalle, James S. W. Seale, et al. "Molecular Pumps and Motors." Journal of the American Chemical Society 143, no. 15 (2021): 5569–91. http://dx.doi.org/10.1021/jacs.0c13388.

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28

Yildiz, Ahmet. "How Molecular Motors Move." Science 311, no. 5762 (2006): 792–93. http://dx.doi.org/10.1126/science.1125068a.

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29

LESLIE, R. J. "Molecular Motors: Cell Movement." Science 244, no. 4912 (1989): 1599. http://dx.doi.org/10.1126/science.244.4912.1599.

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30

Schliwa, Manfred. "Molecular motors join forces." Nature 397, no. 6716 (1999): 204–5. http://dx.doi.org/10.1038/16577.

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31

Tyreman, M. J. A., and J. E. Molloy. "Molecular motors: nature's nanomachines." IEE Proceedings - Nanobiotechnology 150, no. 3 (2003): 95. http://dx.doi.org/10.1049/ip-nbt:20031172.

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32

Michaelis, Jens, Adam Muschielok, Joanna Andrecka, Wolfgang Kügel, and Jeffrey R. Moffitt. "DNA based molecular motors." Physics of Life Reviews 6, no. 4 (2009): 250–66. http://dx.doi.org/10.1016/j.plrev.2009.09.001.

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33

Cross, R. A. "Molecular Motors: Dynein's Gearbox." Current Biology 14, no. 9 (2004): R355—R356. http://dx.doi.org/10.1016/j.cub.2004.04.026.

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34

Santamaria-Holek, Ivan, and Jared López Alamilla. "Determining Molecular Motors Processivity." Biophysical Journal 102, no. 3 (2012): 367a. http://dx.doi.org/10.1016/j.bpj.2011.11.2004.

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35

Meech, Robert, and Matthew Holley. "Ion-age molecular motors." Nature Neuroscience 4, no. 8 (2001): 771–73. http://dx.doi.org/10.1038/90461.

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36

Spudich, James A. "How molecular motors work." Nature 372, no. 6506 (1994): 515–18. http://dx.doi.org/10.1038/372515a0.

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37

Marrucci, L., D. Paparo, and M. Kreuzer. "Fluctuating-friction molecular motors." Journal of Physics: Condensed Matter 13, no. 46 (2001): 10371–82. http://dx.doi.org/10.1088/0953-8984/13/46/309.

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38

Vilfan, A., E. Frey, and F. Schwabl. "Elastically coupled molecular motors." European Physical Journal B 3, no. 4 (1998): 535–46. http://dx.doi.org/10.1007/s100510050343.

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39

Gyoeva, F. K. "Interaction of Molecular Motors." Molecular Biology 39, no. 4 (2005): 614–22. http://dx.doi.org/10.1007/s11008-005-0077-x.

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40

Schalley, Christoph A., and Fritz Vögtle. "International Workshop „Molecular Motors”︁." Nachrichten aus der Chemie 50, no. 2 (2002): 201. http://dx.doi.org/10.1002/nadc.20020500232.

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41

Abe, Yuta, Takeshi Itabashi, Yuta Shimamoto, Tarun M. Capoor, and Shin'ichi Ishiwata. "3P152 Behavior of molecular motors in cytoplasmic extracts(Molecular motors,Oral Presentations)." Seibutsu Butsuri 47, supplement (2007): S241. http://dx.doi.org/10.2142/biophys.47.s241_1.

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42

Tayar, Alexandra M., Michael F. Hagan, and Zvonimir Dogic. "Active liquid crystals powered by force-sensing DNA-motor clusters." Proceedings of the National Academy of Sciences 118, no. 30 (2021): e2102873118. http://dx.doi.org/10.1073/pnas.2102873118.

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Cytoskeletal active nematics exhibit striking nonequilibrium dynamics that are powered by energy-consuming molecular motors. To gain insight into the structure and mechanics of these materials, we design programmable clusters in which kinesin motors are linked by a double-stranded DNA linker. The efficiency by which DNA-based clusters power active nematics depends on both the stepping dynamics of the kinesin motors and the chemical structure of the polymeric linker. Fluorescence anisotropy measurements reveal that the motor clusters, like filamentous microtubules, exhibit local nematic order.

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43

Brady, S. T. "Molecular motors and fast axonal transport." Proceedings, annual meeting, Electron Microscopy Society of America 52 (1994): 22–23. http://dx.doi.org/10.1017/s0424820100167846.

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When video microscopy was first used to study fast axonal transport in isolated axoplasm from squid giant axons, a torrent of membrane traffic was seen to move in both directions. Images of membrane bounded organelles (MBOs) moving along individual microtubules (MTs) in axoplasm opened the way for characterization of the microscopic properties of fast axonal transport and led to the characterization of two molecular motors involved in fast axonal transport. The pharmacology of MBO movement ruled out previously identified molecular motors and a biochemical dissection of fast axonal transport in

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44

Norris, Stephen R., Virupakshi Soppina, Aslan S. Dizaji, et al. "A method for multiprotein assembly in cells reveals independent action of kinesins in complex." Journal of Cell Biology 207, no. 3 (2014): 393–406. http://dx.doi.org/10.1083/jcb.201407086.

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Teams of processive molecular motors are critical for intracellular transport and organization, yet coordination between motors remains poorly understood. Here, we develop a system using protein components to generate assemblies of defined spacing and composition inside cells. This system is applicable to studying macromolecular complexes in the context of cell signaling, motility, and intracellular trafficking. We use the system to study the emergent behavior of kinesin motors in teams. We find that two kinesin motors in complex act independently (do not help or hinder each other) and can alt

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45

Henkin, Gil, Stephen J. DeCamp, Daniel T. N. Chen, Tim Sanchez, and Zvonimir Dogic. "Tunable dynamics of microtubule-based active isotropic gels." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 372, no. 2029 (2014): 20140142. http://dx.doi.org/10.1098/rsta.2014.0142.

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We investigate the dynamics of an active gel of bundled microtubules (MTs) that is driven by clusters of kinesin molecular motors. Upon the addition of ATP, the coordinated action of thousands of molecular motors drives the gel to a highly dynamical turbulent-like state that persists for hours and is only limited by the stability of constituent proteins and the availability of the chemical fuel. We characterize how enhanced transport and emergent macroscopic flows of active gels depend on relevant molecular parameters, including ATP, kinesin motor and depletant concentrations, MT volume fracti

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46

Dunn, K. E., M. C. Leake, A. J. M. Wollman, M. A. Trefzer, S. Johnson, and A. M. Tyrrell. "An experimental study of the putative mechanism of a synthetic autonomous rotary DNA nanomotor." Royal Society Open Science 4, no. 3 (2017): 160767. http://dx.doi.org/10.1098/rsos.160767.

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DNA has been used to construct a wide variety of nanoscale molecular devices. Inspiration for such synthetic molecular machines is frequently drawn from protein motors, which are naturally occurring and ubiquitous. However, despite the fact that rotary motors such as ATP synthase and the bacterial flagellar motor play extremely important roles in nature, very few rotary devices have been constructed using DNA. This paper describes an experimental study of the putative mechanism of a rotary DNA nanomotor, which is based on strand displacement, the phenomenon that powers many synthetic linear DN

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47

KIERFELD, JAN, PAVEL KRAIKIVSKI, and REINHARD LIPOWSKY. "FILAMENT ORDERING AND CLUSTERING BY MOLECULAR MOTORS IN MOTILITY ASSAYS." Biophysical Reviews and Letters 01, no. 04 (2006): 363–74. http://dx.doi.org/10.1142/s1793048006000318.

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We study the cooperative behavior of cytoskeletal filaments in motility assays, in which immobilized motor proteins bind the filaments to a surface and actively pull them along this surface. Because of the repulsive interaction of filaments, the motor-driven dynamics of filaments leads to a nonequilibrium phase transition which generalizes the isotropicnematic phase transition of the corresponding equilibrium system, the hard-rod fluid. Langevin dynamics simulations and analytical theory show that the motor activity enhances the tendency for nematic ordering. At high detachment forces of motor

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48

Ibusuki, Ryota, Tatsuya Morishita, Akane Furuta, et al. "Programmable molecular transport achieved by engineering protein motors to move on DNA nanotubes." Science 375, no. 6585 (2022): 1159–64. http://dx.doi.org/10.1126/science.abj5170.

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Intracellular transport is the basis of microscale logistics within cells and is powered by biomolecular motors. Mimicking transport for in vitro applications has been widely studied; however, the inflexibility in track design and control has hindered practical applications. Here, we developed protein-based motors that move on DNA nanotubes by combining a biomolecular motor dynein and DNA binding proteins. The new motors and DNA-based nanoarchitectures enabled us to arrange the binding sites on the track, locally control the direction of movement, and achieve multiplexed cargo transport by dif

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49

Tafoya, Sara, and Carlos Bustamante. "Molecular switch-like regulation in motor proteins." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1749 (2018): 20170181. http://dx.doi.org/10.1098/rstb.2017.0181.

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Motor proteins are powered by nucleotide hydrolysis and exert mechanical work to carry out many fundamental biological tasks. To ensure their correct and efficient performance, the motors' activities are allosterically regulated by additional factors that enhance or suppress their NTPase activity. Here, we review two highly conserved mechanisms of ATP hydrolysis activation and repression operating in motor proteins—the glutamate switch and the arginine finger—and their associated regulatory factors. We examine the implications of these regulatory mechanisms in proteins that are formed by multi

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50

Spudich, James A. "Molecular motors: forty years of interdisciplinary research." Molecular Biology of the Cell 22, no. 21 (2011): 3936–39. http://dx.doi.org/10.1091/mbc.e11-05-0447.

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A mere forty years ago it was unclear what motor molecules exist in cells that could be responsible for the variety of nonmuscle cell movements, including the “saltatory cytoplasmic particle movements” apparent by light microscopy. One wondered whether nonmuscle cells might have a myosin-like molecule, well known to investigators of muscle. Now we know that there are more than a hundred different molecular motors in eukaryotic cells that drive numerous biological processes and organize the cell's dynamic city plan. Furthermore, in vitro motility assays, taken to the single-molecule level using

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