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Dissertations / Theses on the topic 'Molecular reaction mechanism'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Perruccio, Francesca. "Molecular modelling of the citrate synthase reaction mechanism." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268775.

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2

Ishino, So. "Physicochemical studies on reaction mechanism of molecular chaperone GroE." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199490.

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3

Green, Dale. "A probabilistic approach to reaction coordinate and rate constant modeling applied to epoxide ring-opening reactions." Kansas State University, 2012. http://hdl.handle.net/2097/15085.

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Master of Science<br>Department of Chemical Engineering<br>Keith Hohn<br>The study will utilize a probabilistic reaction modeling method for ring-opening reactions of epoxide. In particular, to elucidate the reaction mechanism by the methods presented, focus will be placed on the nucleophillic attack of ethylene oxide by ammonia and its anion. This focus was chosen because of the potential to gain significant advantage in computational intensity required to model the epoxy-amino macromolecular curing reactions and resulting thermochemical and physical properties of the cured resin. The method

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4

Badieyan, Somayesadat. "Molecular Design and Mechanistic Characterization of Glycoside Hydrolases using Computational and Experimental Techniques." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77989.

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Cellulase activity is due to the activity of multiple enzymes, including endoglucanases, cellobiohydrolases and glucosidases that work synergistically to solubilize crystalline cellulose efficiently. The dependence of hydrolysis reaction rate on temperature predicts that large increases in performance and decreased enzyme cost would be achieved if the enzymatic degradation could be operated at elevated temperatures. However there is always a tradeoff between the activity and stability of enzymes. So obtaining cellulases with high thermostability and simultaneously enhanced activity is a great

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5

Tosha, Takehiko. "Molecular mechanism of cytochrome p450cam-catalyzed oxygenation reaction regulated by the association with putidaredoxin." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148546.

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6

Fukutome, Asuka. "VAPOR-PHASE REACTION AND ITS ROLE IN CELLULOSE GASIFICATION." Kyoto University, 2017. http://hdl.handle.net/2433/218023.

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7

Svalberg, Linn. "Determining the Reaction Mechanism of Hydrolysis of p-Nitrophenyl Butyrate Performed by a Cold-Adapted Lipase, BplA : Finding the Rate-Limiting Step." Thesis, Uppsala universitet, Beräkningsbiologi och bioinformatik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446666.

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Lipases are one of the most important biocatalysts for biotechnological applications. They have high importance since lipases have a catalytic activity that is related to their hydrolysis and synthesis reactions to high regioselectivity and enantioselectivity. They also have an activity over a wide range of temperature, pH, and diverse substrates. The aim of this master thesis project was to apply computational calculations to understand the reaction mechanism of the hydrolysis of p-nitrophenyl butyrate performed by the cold-adapted lipase, Bacillus pumilus Lipase A (BplA). Cold-adapted lipase

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8

Rahmouni, Abderrahim. "Reaction de la drogue antitumorale, le cis-dichlorodiammineplatine (ii) avec l'acide desoxyribonucleique : etude des complexes interbrins." Orléans, 1987. http://www.theses.fr/1987ORLE2047.

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9

Pu, Maoping. "Molecular Motion in Frustrated Lewis Pair Chemistry: insights from modelling." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-122348.

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Mechanisms of reactions of the frustrated Lewis pairs (FLPs) with carbon dioxide (CO2) and hydrogen (H2) are studied by using quantum chemical modelling. FLPs are relatively novel chemical systems in which steric effects prevent a Lewis base (LB) from donating its electron pair to a Lewis acid (LA). From the main group of the periodic table, a variety of the electron pair donors and acceptors can create an FLP and the scope of the FLP chemistry is rapidly expanding at present. Representative intermolecular FLPs are phosphines and boranes with bulky electron-donating groups on phosphorus and bu

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10

Garrido, Barros Pablo. "Molecular Water Oxidation Catalysts Based on Copper and Nickel Complexes." Doctoral thesis, Universitat Rovira i Virgili, 2018. http://hdl.handle.net/10803/665124.

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Aquesta Tesi Doctoral es centra en l’estudi de catalitzadors moleculars per a l’oxidació d’aigua basats en coure i níquel, ja que la seva gran abundància i baix cost els fa potencials candidats pel seu ús en sistemes catalítics. Tot i així, avui en dia hi ha una important mancança d’informació respecte als seus mecanismes de reacció i els factors que influeixen la seva activitat. Per això, en primer lloc, es desenvolupen nous catalitzadors moleculars basats en el coure com a centre metàl·lic. L’estudi mecanístic d’aquests catalitzadors revela l’important rol que té l’oxidació del lligand

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11

Song, Hua. "Investigation of Reaction Networks and Active Sites in Bio-ethanol Steam Reforming over Cobalt based Catalysts." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243999804.

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12

Girard, Bertrand. "Etude de la collision reactive ii + f -> if + i par fluorescence induite par laser." Paris 6, 1987. http://www.theses.fr/1987PA066398.

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Etude de cette collision par la methode des faisceaux croises et grace a la transition (b <- x) intense, dans le visible, apres analyse de la saturation du processus d'excitation laser de cette transition de if forme. Deduction des populations des differents niveaux rovibrationnels de l'etat x. Etablissement d'une cartographie detaillee de la distribution rotationnelle des niveaux vibrationnels v = 8 a 20 de l'etat x de if: aspect bimodal qui implique la coexistence de deux chemins reactionnels differents. Attribution a un artefact de l'important signal observe anterieurement pour v = 0. Mesur

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13

Coldren, William Henry. "Theoretical Studies of Reactive Intermediates in Complex Reaction Mechanisms." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531497707269833.

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14

CAMPISTRON, GUILMET IRENE. "La reaction de metathese : synthese de molecules modeles et de diesters polydieniques, degradation controlee des polydienes." Le Mans, 1987. http://www.theses.fr/1987LEMA1021.

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Amelioration des processus de synthese des composes modeles des polydienes et d'oligomeres alpha , omega -bifonctionnels par reaction de cometatheses du cyclooctadiene-1,5 avec l'octene-4, le methyl-4 octene-4, l'hexadiene-1,5 et l'hexene-3 dioate de dimethyle

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15

Raoul, Sébastien. "Réactions d'oxydation des bases puriques des acides nucléiques." Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE10178.

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Les modifications des bases de l'adn, support de l'information genetique, sont une des causes possibles de la mutagenese et la cancerogenese. Bien souvent ces modifications sont de type oxydatives. Elles sont induites par les especes reactives de l'oxygene, formees lors du metabolisme cellulaire et/ou par l'action de divers rayonnements (ionisants, uv, visible). Les mecanismes d'oxydation des deux bases puriques de l'adn, l'adenine et la guanine, ont ete etudies en identifiant et caracterisant les produits finals resultant de l'oxydation des nucleosides correspondants, pris comme systemes mode

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16

Raspopovic, Jelena 1984. "Molecular basis for digit patterning in the vertebrate limb : Digit patterning in controlled by a BMP-Sox9-Wnt Turing network modulated by morphogen gradients." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/286922.

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Aquesta tesi es centra en la identificació de les molècules de la xarxa de Turing que controla el patró dels dits en l'extremitat del ratolí. L’especificació dels dits ha estat explicada a la llum del model de Positional Information i el gradient temporal-espacial de Sonic Hede Hog (Shh). No obstant, manipulacions embrionàries i genètics han demostrat que Shh no és necessari per l'especificació dels dits i han proposat que en lloc aquest procés pot ser controlat per una xarxa de reacció-difusió de Turing. Malgrat l'extens modelatge teòric, les molècules de la xarxa de Turing va romandre descon

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17

Roos, Annette K. "Structural and Functional Studies of Ribose-5-phosphate isomerase B." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8182.

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18

Meziane, Driss. "Etude de la polymérisation des alcynes amorcée par un dérivé alkylidène du tungstène." Paris 13, 1986. http://www.theses.fr/1986PA132002.

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19

RACAPE, EVELYNE. "Influence des fonctions amides sur les proprietes physicochimiques des pectines." Nantes, 1989. http://www.theses.fr/1989NANT2001.

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Gelification des pectines amidees en presence de calcium. Etude de modeles simplifies (acides pectiques amides). Les pko dependent du parametre de densite de charge et non pas du taux d'amidation/repartition non aleatoire des fonctions amides. La sensibilite au calcium des pectines amidees resulte de l'alternance de blocs de fonctions acides libres et methyles reparties aleatoirement et de fonctions amides, generateurs de liaisons h intermoleculaires, provenant de leur synthese concentre en ammoniac et en pectine

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20

Greaves, Stuart Jeffrey. "Theoretical and experimental studies of molecular motions and reaction mechanisms." Thesis, Durham University, 2005. http://etheses.dur.ac.uk/2621/.

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The time-delayed forwards scattering mechanism recently observed by Althorpe et al. [1] for the H + D2 (v=O, j=O) --? HD(v'=3, j'=O) + D reaction was analysed using the quasi-classical trajectory (QCT) methodology. QCT's were found to reasonably match the quantum snapshots of Althorpe, without the quantum effects. Trajectories were analysed on the fly to investigate the motions of the atoms during the reaction. The dominant reaction mechanism progresses from hard collinear impacts, leading to direct recoil, to glancing impacts. The increased time required for forward scattered trajectories is

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21

Jenzer, Herbert Kurt. "Molecular mechanisms and side reactions of thyroid hormone biosynthesis /." [S.l : s.n.], 1987. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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22

Blaghen, Mohamed. "Etude de la mercuri-reductase de yersinia enterocolitica souche 138a14 : purification, caracterisation et cristallisation." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13072.

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23

Mazza, Catherine. "17-hydroxystéroïde déshydrogénase humaine de type I : analyse des relations structure-fonction par mutagenèse dirigée et cristallographie des rayons X." Université Joseph Fourier (Grenoble ; 1971-2015), 1997. http://www.theses.fr/1997GRE10214.

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La 17-hydroxysteroide deshydrogenase de type 1 (17-hsd1) est responsable de la synthese de l'stradiol, strogene biologiquement actif implique dans le declenchement et la proliferation des cancers du sein hormono-dependants. Cette enzyme appartient a la famille des deshydrogenases reductases a chaine courte dans laquelle les residus ser142 tyr155 et lys159, tres conserves, sont supposes intervenir dans le transfert de proton. La 17-hsd1 presente une specificite exclusive, mais inexpliquee vis-a-vis des steroides possedant un cycle a aromatique. De plus, elle utilise, in vitro, aussi bien le nad

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24

Craven, Galen Thomas. "Minimalist theory for mesoscale reaction dynamics." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54292.

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The prediction of an atomistic system's macroscopic observables from microscopic physical characteristics is often intractable, either by theory or computation, due to the intrinsic complexity of the underlying dynamical rules. This complexity can be simplified by identifying key mechanisms that drive behavior and considering the system in a reduced representation that captures these mechanisms. Through theory, this thesis examines complex relationships in structured assembly and reaction mechanisms that occur when effective interactions are applied to mesoscale structures. In the first part o

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25

Graige, Michael Scott. "Revealing the mechanisms and energetics of electron and proton transfer reactions in photosynthetic reaction centers from Rb. sphaeroides using molecular probes /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9908502.

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26

Meliá, Fortuño Concepción. "Quantum Mechanics/Molecular Mechanics modeling of biological relevant reactions catalyzed by enzymes." Doctoral thesis, Universitat Jaume I, 2017. http://hdl.handle.net/10803/455140.

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A theoretical study of the hydrolysis of a β-lactam antibiotic was carried out in gas phase at different levels of theory. Later, the reaction was studied in solution, describing the sub-set of atoms of the QM region with semiempirical and density functional theory methods while classical force fields were used to describe the explicit solvent water molecules. QM/MM Molecular Dynamics simulations were used to generate the potential of mean force for the reaction in solution. The mechanism of hydrolysis of two antibiotics were explored in the active site of a mononuclear β lactamase. QM/MM meth

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27

Ainsley, Jon. "Computational simulations of enzyme dynamics and the modelling of their reaction mechanisms." Thesis, Northumbria University, 2017. http://nrl.northumbria.ac.uk/36286/.

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Proteins and enzymes are large and complex biological molecules, characterized by unique three-dimensional structure are highly flexible and dynamic nature. Thorough understanding of protein and enzyme function requires studying of their conformational flexibility, because important physiological processes, such as ligand binding and catalysis rely on an enzyme’s dynamic nature and their ability to adopt a variety of conformational states. Computational methods are widely applied in studying enzymes and proteins structure and function providing a detailed atomistic-level of resolution data abo

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28

Zaidi, Aisha Muftah. "The Role of C Reactive Protein on Molecular Mechanism of Atherosclerosis." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515025.

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29

Ma, Thong Chi. "The molecular mechanisms of free 3-nitrotyrosine neurotoxicity." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189707727.

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30

Yamamoto, Shinichiro. "Reactive Oxygen Species / Reactive Nitrogen Species-sensitive TRP channels : Molecular Activation Mechanism and Physiological Significance." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/124503.

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31

Fountain, Tina Lynn. "Reaction dynamics of high temperature systems : I. O ̄⁺ H₂ products II. O ̄⁺ H₂ products." Diss., Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/29190.

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32

Kolmodin, Karin. "Computer Simulation of Protein Tyrosine Phosphatase Reaction Mechanisms and Dihydrofolate Reductase Inhibition." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : [Univ.-bibl. [distributör]], 2001. http://publications.uu.se/theses/91-554-5148-9/.

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33

Joo, Hyun. "Exploring potential energy sources and reaction mechanisms of inorganic molecules by computational methods." Auburn, Ala., 2005. http://repo.lib.auburn.edu/2005%20Fall/Dissertation/JOO_HYUN_55.pdf.

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34

Chirasani, Sridhar Reddy. "Cellular and molecular mechanisms of glioma growth control." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/16032.

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Im ersten Teil meiner Arbeit habe ich den molekularen Mechanismus beschrieben, mit dem endogene neuronale Vorläuferzellen antitumorigen gegen Gliomstammzellen wirken. Unsere Forschungsgruppe hat in bereits veröffentlichten Arbeiten gezeigt, dass neuronale Vorläuferzellen zu experimentellen Gehirntumoren migrieren und Tumorzelltod induzieren können. In der nun vorliegenden Arbeit zeige ich, dass die neuronalen Vorläuferzellen nicht nur benefiziell gegen die Hauptpopulation der Tumorzellen wirken, sondern darüber hinaus auch die kleinere Population der sehr aggressiven Tumorstammzellen – mittel

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35

Oldfield, Lyndon Carey. "Elucidation of the reaction mechanisms involved in the catalysis mediated by glutamine synthetase in Escherichia coli." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/14642.

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Includes bibliographical references (leaves 117-125).<br>Structural and molecular dynamics analysis of the glutamine synthetase from E. coli indicates that a possible mechanism by which the adenylylation/deadenylylation of the enzyme affects the enzyme specificity for either MgATP or Mn2ATP and NH4+ or NH3, is by switching between two putative serine protease-like catalytic triads. Site-directed mutagenesis of a number of residues identiï¬ ed as playing a role in these catalytic triads, led to the following observations. Both Ser52 and Ser53 were important for the catalytic activity of the enz

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36

Ji, Yongfei. "Theoretical Studies on the Molecular Mechanisms of Photo-Catalytic Reactions on TiO2 Surfaces." Doctoral thesis, KTH, Teoretisk kemi och biologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-145146.

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Photocatalysis is a promising technology that can effectively convert the solar energyinto sustainable green energy. However, theoretical studies on the molecular mechanisms of photocatalytic reactions are rare. This thesis is devoted to investigate several typical photocatalytic reactions on the surfaces of the most popular photocatalysis TiO2 with density functional theory. We start our study with the characterization of both the free and trapped hole on the surface generated by the light. The oxidation of physisorbed H2O molecule by the hole trapped at bridge oxygen on rutile TiO2(110) surf

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37

Rogueda, Catherine. "Etude comparee de la copolymerisation alternee du styrene et du methacrylate de methyle en solution dans le toluene ou dans le tetrachlorure de carbone." Paris 6, 1987. http://www.theses.fr/1987PA066203.

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Etude cinetique de la copolymerisation du styrene et du methacrylate de methyle en presence d'aletcl::(2) ou alet::(2)cl en solution dans du toluene ou du tetrachlorure de carbone. Analyse d'un mecanisme faisant intervenir des reactions de propagation croisees

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38

Zuo, Li. "Molecular Mechanisms of Stress-induced Reactive Oxygen Species Formation in Skeletal Muscle." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1038853894.

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39

Astilean, Simion. "Transfert photoinduit de protons dans des cristaux mixtes pentacène/acide benzoi͏̈que caractérisé par spectroscopie optique." Grenoble 1, 1993. http://www.theses.fr/1993GRE10129.

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L'excitation optique a basse temperature du pentacene en site de substitution dans des cristaux d'acide benzoique conduit a l'apparition de nouvelles raies d'absorption correspondant a des sites de defaut (photosites). Ces defauts, qui disparaissent spontanement dans le noir, resultent d'un deplacement des protons acides de la matrice hors de leur position d'equilibre. Nous montrons que la deuteration des protons acides de la matrice entraine une diminution d'un facteur 10#4 du rendement de formation des photosites et d'un facteur 10#3 a 10#5 de la vitesse de la reaction retour, ce qui indique

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40

Zhong, Shifa. "Permanganate Reaction Kinetics and Mechanisms and Machine Learning Application in Oxidative Water Treatment." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1618686803768471.

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41

Azad, Neelam. "Molecular mechanisms of chromium (VI)-induced apoptosis and malignant transformation." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5041.

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Thesis (Ph. D.)--West Virginia University, 2007.<br>Title from document title page. Document formatted into pages; contains ix, 103 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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42

Struebing, Heiko. "Identifying optimal solvents for reactions using quantum mechanics and computer-aided molecular design." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9150.

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A new iterative hybrid methodology, incorporating quantum mechanics (QM) calculations and a computationally inexpensive computer-aided molecular design (CAMD) methodology, QM-CAMD, for identification of optimal solvents for reactions is presented. The methodology has been applied to a Menschutkin reaction, where pyridine and phenacyl bromide are the reactants. The QM calculations take on the form of density functional theory calculations with a given solvent treated using continuum solvation models. The accuracy of the solvent QM calculations is assessed by computing free energies of solvation

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43

Kazemi, Masoud. "Calculations of Reaction Mechanisms and Entropic Effects in Enzyme Catalysis." Doctoral thesis, Uppsala universitet, Beräkningsbiologi och bioinformatik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316497.

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Ground state destabilization is a hypothesis to explain enzyme catalysis. The most popular interpretation of it is the entropic effect, which states that enzymes accelerate biochemical reactions by bringing the reactants to a favorable position and orientation and the entropy cost of this is compensated by enthalpy of binding. Once the enzyme-substrate complex is formed, the reaction could proceed with negligible entropy cost. Deamination of cytidine catalyzed by E.coli cytidine deaminase appears to agree with this hypothesis. In this reaction, the chemical transformation occurs with a negligi

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44

Etienne, Michel. "Réactivité de complexes dinucléaires hydrure et alcénylidène ponte du fer vis-a-vis d'hydrocarbures cyanes insatures (mono et dicyanoacétylène, tétracyanoethylène)." Brest, 1988. http://www.theses.fr/1988BRES2009.

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Preparation de complexes avec des coordinats cyano-4 butadienyldene portants. On obtient egalement des complexes dinucleaires avec le tricyano-3,4,4 butadienylidene-1,3. Mecanisme ses reactions de migration de l'hydrogene allylique

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45

Voleti, Bhavya. "Mechanism of Transcriptional Regulation of C-Reactive Protein Gene Expression." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etd/2058.

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C-reactive protein (CRP) is an acute phase protein produced by hepatocytes whose serum concentration increases in inflammatory conditions including cardiovascular complications. Statins that are used in the treatment of cardiovascular diseases to reduce cholesterol also lower serum CRP levels. In human hepatoma Hep3B cells, CRP is induced in response to cytokines IL-6 and IL-1β. The objective of the study was to determine the mechanism of regulation of CRP gene expression in Hep3B cells in response to cytokines and to determine the effect of statins on CRP expression. Key findings of our resea

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46

Johansson, Helena. "Mechanisms and Therapeutic Interventions of Instant Blood-Mediated Inflammatory Reaction (IBMIR)." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7786.

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Gang, Toh B. "Mechanisms of the Anti-Pneumococcal Function of C-Reactive Protein." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etd/2292.

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Human C-reactive protein (CRP) increases survival of and decreases bacteremia in mice infected with Streptococcus pneumoniae. Such protection of mice against pneumococcal infection is seen only when CRP is administered into mice 6 hours before to 2 hours after the injection of pneumococci, but not when CRP is given to mice at a later time. Our first aim was to define the mechanism of CRP-mediated initial protection of mice against infection. It was proposed that CRP binds to phosphocholine (PCh) moieties present in the cell wall and activates the complement system on the pneumococcal surface t

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48

Townsend, Michael Arthur Edward. "A Computational Investigation of the Biosynthesis of Lanosterol." Thesis, University of Canterbury. Chemistry, 2006. http://hdl.handle.net/10092/1329.

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The biosynthesis of the steroid precursor molecule lanosterol is a remarkable process in which the enzyme-bound substrate 2,3-S-oxidosqualene forms four new carbocyclic rings by a cascade of cation-alkene addition reactions, followed by a series of 1,2-methyl and hydride shifts. The work presented in this thesis is a computational study of the reactions of compounds designed to model the oxidosqualene-lanosterol cyclisation in order to establish details of the mechanism of this amazing cyclisation. The initiation of oxidosqualene cyclisation has been modelled by the intermolecular reaction of

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49

Dilbeck, Preston Lee. "Proton transfer reactions in photosynthetic water oxidation| Second sphere ligands of the manganese cluster modulate the water oxidation mechanism of photosystem ii." Thesis, Oklahoma State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3614379.

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<p> In the D1-D61N mutant, it was possible to resolve a clear lag phase prior to the appearance of O2, indicating formation of an intermediate before onset of O2 formation. The lag phase and the photochemical miss factor were more sensitive to isotope substitution in the mutant indicating that proton efflux in the mutant proceeds via an alternative pathway. The results are discussed in comparison with earlier results obtained from the substitution of CP43-Arg357 with lysine and in regards to hypotheses concerning the nature of the final steps in photosynthetic water oxidation. These conside

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Garba, Nana Aisha. "The Role of Redox Signaling in the Molecular Mechanism of Tamoxifen Resistance in Breast Cancer." FIU Digital Commons, 2012. http://digitalcommons.fiu.edu/etd/551.

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Abstract:

The emergence of tamoxifen or aromatase inhibitor resistance is a major problem in the treatment of breast cancer. The molecular signaling mechanism of antiestrogen resistance is not clear. Understanding the mechanisms by which resistance to these agents arise could have major clinical implications for preventing or circumventing it. Therefore, in this dissertation we have investigated the molecular mechanisms underlying antiestrogen resistance by studying the contributions of reactive oxygen species (ROS)-induced redox signaling pathways in antiestrogen resistant breast cancer cells. Our hypo

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