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Dissertations / Theses on the topic 'Molecular receptors'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 April 2022

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1

Björnström, Linda. "Molecular mechanisms of alternative estrogen receptor signaling /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-509-3/.

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2

Kovoor, Abraham. "Molecular regulation of opioid receptors /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/6278.

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3

Meira, Guilherme Louzada Silva. "Analíse da expressão do receptor olfativo M93 em sistemas heterólogos." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-31082016-115408/.

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O sistema olfatório de mamífero pode discriminar milhares de odores presentes no meio ambiente. Aproximadamente 1000 diferentes receptores olfatórios (ORs) são expressos no epitélio olfatório (OE) do nariz, Os ORs detectam os odores e transmitem os sinais resultantes para o bulbo olfatório (OB) no cérebro. Os ORs pertencem a super família dos receptores acoplados a proteína G (GPCR) e apresentam sete domínios transmembrânicos putativos. Por razões desconhecidas, os ORs são retidos no retículo endoplasmático quando expressos em linhagens de células de mamíferos heterólogas. Provavelmente, prote

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4

McGinley, Paula Lynn. "Molecular complementation of mutant hormone receptors." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 189 p, 2008. http://proquest.umi.com/pqdweb?did=1456289611&sid=5&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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5

Kuswandi, Susi Iravati. "Molecular genetic analysis of aerobactin receptors." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/34438.

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Some Enterobacteriaceae produce a low molecular weight compound, aerobactin, with a high affinity for ferric iron. The genes encoding the aerobactin system have been identified in plasmid or chromosomal DNA; they are arranged in an operon consisting of five genes; four genes encode enzymes responsible for the biosynthesis of aerobactin and the fifth encodes an outer membrane receptor protein specific for ferric aerobactin. The aerobactin receptor protein appears to be different in size (molecular weight) in different species. Escherichia coli (ColV-K30) express a 74 kDa protein, while Shigella

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6

Beltrán, Sáez Elisa. "Information transmission through a nonlinear molecular signaling system: ErbB as a case study." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667354.

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La capacitat dels éssers vius d’obtenir i processar informació és clau per adaptar-se i sobreviure en l’ambient que els envolta. Les cèl·lules, des de procariotes unicel·lulars fins a organismes multicel·lulars (eucariotes), capten informació de l’entorn mitjançant diversos mecanismes, entre ells a través de receptors de membrana, que fan de canal per a la informació entre l’exterior i l’interior de la cèl·lula. Per tant, aquestos receptors representen un canal de transmissió d’informació a través del qual la informació ambiental pot afectar el comportament cel·lular per adaptar-se a l’ambient

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7

Zhang, Gaiping. "Bovine IgG Fc receptors." Thesis, University of Hertfordshire, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387187.

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8

Torvinen, Maria. "Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-298-1/.

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9

Cordomí, Montoya Arnau. "Molecular dynamics simulations of seven-transmembrane receptors." Doctoral thesis, Universitat Politècnica de Catalunya, 2008. http://hdl.handle.net/10803/6464.

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Seven transmembrane (7-TM) G protein coupled receptors (GPCR) constitute the largest family of integral membrane proteins in eukaryotes with more than 1000 members and encoding more than 2% of the human genome. These proteins play a key role in the transmission and transduction of cellular signals responding to hormones, neurotransmitters, light and other agonists, regulating basic biological processes. Their natural abundance together with their localization in the cell membrane makes them suitable targets for therapeutic intervention. Consequently, GPCR are proteins with enormous pharmacolog

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10

Hodyl, Jozef Andrew Zbigniew, and jozef hodyl@flinders edu au. "Silica Immobilised Metal Ion Activated Molecular Receptors." Flinders University. School of Chemistry, Physics and Earth Sciences, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20090301.162335.

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Immobilisation of functional entities, such as, enzymes, onto solid supports, as a means of facilitating their removal from the surrounding environment and subsequent regeneration has been in practice for many decades. This work focuses on the immobilisation and analysis of three-walled (pendant armed), cyclen based receptor complexes immobilised onto a silica surface for the purpose of sequestering aromatic anions from aqueous solution: Si-GPS-[Cd(Trac)](ClO4)2, Si-GPS-[Cd(DiPTrac)](ClO4)2, and Si-GPS-[Cd(TriPTrac)](ClO4)2 were the immobilised receptors used. Initially, synthesis of a three-

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11

Kasorn, Anongnard. "The molecular pharmacology of lysophosphatidic acid receptors." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441003.

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12

Rocheville, Magalie. "Oligomerization of somatostatin receptors." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84425.

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Oligomerization of membrane proteins in response to external stimulation is a common event in cell signalling for generating functional diversity. In the case of the heptahelical receptor (HHR) superfamily, the traditional view has been that these receptors function as monomers, although a number of recent studies have suggested that this class of membrane proteins may exist as dimers or higher order oligomers, and play an important role in signalling. We addressed this question using as a model the somatostatin receptor (SSTR) family, which comprises five molecular subtypes (SSTR1--5).

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13

Nilsson, Isabelle. "The cholecystokinin receptor family : molecular cloning and pharmacological characterization /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med791s.pdf.

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14

Josephson, Anna. "Spinal cord injury: mechanical and molecular aspects /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-235-3/.

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15

Slessareva, Janna Eugenievna. "Molecular mechanisms of G protein-receptor coupling." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2907.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains vi, 200 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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16

Ma, Hongzheng. "Molecular mechanisms of G protein-receptor coupling." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2978.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains viii, 264 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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17

Nawaz, Zafar. "Molecular Mechanism of Action of Steroid Hormone Receptors." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc798398/.

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A novel bacterial expression system that is capable of producing high levels of soluble, stable, biologically active human vitamin D3 and estrogen receptors has been developed. The method utilizes ubiquitin fusion technology and a low temperature nalidixic acid induction of the lambda PL promoter. This system can produce large quantities of receptor antigen, but only a small fraction displays wild-type DNA and hormone binding properties. Therefore, the use of this system to overproduce receptors for crystallization studies is not practical. To overcome these problems, a 2 um based ubiquitin fu

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18

Tremblay, Annie. "Transcriptional regulation by the estrogen-related receptors." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86701.

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The Estrogen-Related receptors (ERRα, ERRβ and ERRγ) are ubiquitous, constitutively active, orphan nuclear receptors and little is known concerning post-translational modifications affecting their transcriptional activity. We observed that the conserved phosphorylation-dependent sumoylation motif (PDSM) within the N-terminal domain of the ERRs represses their transcriptional activity on compound promoters via a synergy control mechanism. We also identified protein inhibitor of activated stat y (PIASy), a SUMO E3 ligase, as a new interacting partner of ERRα which promotes the sumoylation of ER

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19

Trupp, Miles. "Neurotrophic signalling by GDNF and its receptors /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980602trup.

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20

Futch, Tracy Ann. "Extracellular matrix protein receptors in Drosophila melanogaster." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280545.

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The extracellular matrix (ECM) is defined as the many different proteins and secreted substances between cells. The ECM plays a major role in the signaling pathways that stimulate cells to perform many varied functions, ranging from control of gene expression at the cellular level to differentiation and development of tissues, organs, and ultimately the entire organism. A portion of this work describes the identification of the division abnormally delayed gene, which encodes a proteoglycan, that is involved in growth factor reception with important developmental consequences in Drosophila mel

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21

Tam, Kal-van, and 譚珈詠. "Molecular evolution of secretin/glucagon receptor superfamily in osteichthyans." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45693092.

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22

Talvik, Mirjam. "Clinical molecular imaging of schizophrenia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-587-5/.

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23

Marcu, Jahan Phillip. "Novel Insights into CB1 Receptor Signaling and the Anabolic Role of Cannabinoid Receptors in Bone." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/233543.

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Cell Biology<br>Ph.D.<br>Activation of the CB1 receptor is modulated by aspartate residue D2.63176 in transmembrane helix (TMH) II. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB1 receptor. Studies in class A GPCRs have suggested an ionic interaction between residues of TMHII and VII. In this report, modeling studies identified residue K373, in the extracellular (EC)-3 loop, in charged interactions with D2.63. We investigated this possibility by performing reciprocal mutations and biochemical studies. D2.63176A, K373A, D2.63176A-K373A, and the reciprocal mutant

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24

Carlsson, Peter. "Nuclear receptors studied by molecular dynamics computer simulations /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-823-8.

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25

Salaneck, Erik. "Molecular Evolution of Neuropeptide Y Receptors in Vertebrates." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4988-3/.

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26

Kwok, Ho-yan Amy, and 郭可茵. "Molecular cloning and characterization of chicken prostaglandin receptors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508336.

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27

Kwok, Ho-yan Amy. "Molecular cloning and characterization of chicken prostaglandin receptors." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508336.

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28

Gupta, Srishti. "Molecular analysis of Bacillus megaterium spore germinant receptors." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708193.

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29

Collins, T. "Molecular pharmacological characterisation of neuronal nicotinic acetylcholine receptors." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/624494/.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are excitatory ligand‐gated ion channels that perform important roles throughout the nervous systems of both vertebrate and invertebrate organisms. Impairments to human nAChRs and cholinergic transmission are thought to underlie the pathophysiologies of several neurological and psychological diseases including schizophrenia, Alzheimer’s disease, Parkinson’s disease and certain forms of epilepsy. They are also the receptors that mediate the effects of tobacco smoking and contribute to the physiological and psychological changes associated with

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30

Takase, Masayoshi. "Molecular Recognition Abilities of Ferrocene-Modified Multitopic Receptors." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/149097.

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31

Barkhem, Tomas. "Molecular mechanisms of estrogen and antiestrogen action /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-359-7/.

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32

馬智謙 and Chi-him Eddie Ma. "Molecular studies of gonadotropin releasing hormone receptors and estrogen receptors in goldfish (Carassius auratus)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B4257531X.

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33

Ma, Chi-him Eddie. "Molecular studies of gonadotropin releasing hormone receptors and estrogen receptors in goldfish (Carassius auratus)." Click to view the E-thesis via HKUTO, 2000. http://sunzi.lib.hku.hk/hkuto/record/B4257531X.

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34

Lau, Suk-ling Joanna, and 劉淑玲. "Molecular characterization of the chicken growth hormone receptorgene." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45015430.

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35

Nakahara, Thiago Seike 1989. "Caracterização molecular e funcional de receptores da classe OR expressos no órgão vomeronasal de mamíferos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316387.

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Orientador: Fabio Papes<br>Texto em português e inglês<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-25T08:04:04Z (GMT). No. of bitstreams: 1 Nakahara_ThiagoSeike_M.pdf: 27685441 bytes, checksum: c755af1be54c3ba9b204bed05559dd88 (MD5) Previous issue date: 2014<br>Resumo: O Sistema Olfativo é um Sistema Sensorial complexo, composto por diversos subsistemas cuja integração no cérebro resulta na interação entre os animais e seus respectivos ambientes de maneira adequada. Essa adequação pode significar respostas compor

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36

Andersson, Monika. "Thyroid hormones and their receptors in transcriptional regulation /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2744-8.

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37

Ryan, Tomás John. "Functional investigation of NMDA receptor molecular evolution." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608544.

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38

Silveira, Rodrigo Leandro 1986. "Simulações de dinâmica molecular do receptor ativado de proliferadores de peroxissomos isoforma y." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248857.

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Orientador: Munir Salomão Skaf<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-17T03:48:48Z (GMT). No. of bitstreams: 1 Silveira_RodrigoLeandro_M.pdf: 13554093 bytes, checksum: 1eb767e5bca2a60380f38f58f585e5fd (MD5) Previous issue date: 2010<br>Resumo: O Receptor Ativado de Proliferadores de Peroxissomos Isoforma g (PPARg ) é uma proteína pertencente à superfamília dos Receptores Nucleares. Através da ligação de pequenas moléculas, o PPARg controla a transcrição de genes ligados à diferenciação de adipócitos e ao meta

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39

Im, Jin Seon. "Molecular characterization of T cell receptors and non-MHC restricted T cell receptor binding peptides." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284969.

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T cells recognize antigenic peptides presented by MHC molecules on antigen presenting cells (APC) through T cell receptors (TCRs). Since TCRs are very similar to antibodies in structure and genetics, TCRs might have the potential to bind free antigens as antibodies do. Here, peptides which bound TCRs irrespective of MHC molecules have been identified by screening "one-bead one-peptide" combinatorial libraries. Peptides: VRENAR, RTGNYV, GKMHFK, KDAVKR and RKPQAI bound recombinant Jurkat single chain T cell receptors (scTcrs). GKMHFK, KDAVKR and RKPQAI were also specific for natural TCRs on the

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40

Chung, Ming-kar Karl, and 鍾銘家. "Molecular characterization of chicken glutamate receptor, metabotropic1 (GRM 1)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617941.

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Glutamate is the most abundant excitatory neurotransmitter in the mammalian nervous system. Ionotropic glutamate receptors used to be the only type of glutamate receptors, bringing about essential functions including synaptic transmissions. Since 1991, eight metabotropic glutamate receptors have been discovered. Belonging to the subfamily C of G protein-coupled receptor (GPCR) superfamily, these receptors have unique structural features. They couple to their own specific G proteins and transduce signals via pathways not recognized in other subfamilies. To date, little information on these rec

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41

Aust, Jonathan Gavin. "Molecular and physiological investigations of fish renin-angiotensin systems." Thesis, University of Exeter, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248168.

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42

Chen, Changfeng. "Retinoic acid receptors and mouse epidermal tumorigenesis and development." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84492.

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Retinoic acid (RA), the major biologically active form of vitamin A, plays important roles in regulating a broad range of biological processes.<br>Progressive loss of RARs is associated with skin carcinogenesis both in human and animals. Despite such observations, the biological significance of RAR loss in skin carcinogenesis has not yet been clarified. To this end, we established keratinocyte cell lines deficient in RARalpha, RARgamma, or both and employed a well-established tumorigenesis model to investigate whether loss of RARs is causally related to skin tumorigenesis. We found that

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43

Lundström, Linda. "Subtype selective activation and molecular characterization of galanin receptors." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1344.

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Showing an extensive distribution in the nervous system, and often in co-localization with the classical neurotransmitters, neuropeptides are functioning as important modulators of neuronal signaling. Subsequently, compelling evidence has implicated a modulatory role for the neuropeptide galanin in several physiological functions. The effect of galanin is trancduced intracellularly by three different receptors, and defining the explicit effect from these receptor subtypes is of outmost interest, and likely to result in future therapeutic utilization of the galanin system. The main aim of this

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44

Meyer, Annika Kristin [Verfasser]. "Molecular Receptors Based on Bridged Corannulenes / Annika Kristin Meyer." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1119810906/34.

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45

Lundström, Linda. "Subtype selective activation and molecular characterization of galanin receptors /." Stockholm : Department of Neurochemistry, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1344.

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46

Ishimaru, Hiroshi. "Molecular biology of novel glutamate receptors in Xenopus laevis." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309048.

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47

Maughfling, Edward John Rosewarne. "Molecular basis for the ligand selectivity of bombesin receptors." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625098.

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48

Hadingham, Karen Louise. "Molecular and genetic analysis of cellular receptors for enteroviruses." Thesis, University of Reading, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278055.

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49

Kirwan, Michael Joseph. "Molecular cloning and characterisation of insect nicotinic acetylcholine receptors." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408548.

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50

Purohit, Prasad G. "Molecular determinants of pharmacological distinctions among nicotinic acetylcholine receptors." Thesis, University of Strathclyde, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424352.

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