Relevant bibliographies by topics / Molecularly Imprinted Fluorescent Sensor

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  2. Dissertations / Theses
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Academic literature on the topic 'Molecularly Imprinted Fluorescent Sensor'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 September 2023

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Journal articles on the topic "Molecularly Imprinted Fluorescent Sensor"

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Liu, Guangyang, Xiaodong Huang, Lingyun Li, et al. "Recent Advances and Perspectives of Molecularly Imprinted Polymer-Based Fluorescent Sensors in Food and Environment Analysis." Nanomaterials 9, no. 7 (2019): 1030. http://dx.doi.org/10.3390/nano9071030.

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Molecular imprinting technology (MIT), also known as molecular template technology, is a new technology involving material chemistry, polymer chemistry, biochemistry, and other multi-disciplinary approaches. This technology is used to realize the unique recognition ability of three-dimensional crosslinked polymers, called the molecularly imprinted polymers (MIPs). MIPs demonstrate a wide range of applicability, good plasticity, stability, and high selectivity, and their internal recognition sites can be selectively combined with template molecules to achieve selective recognition. A molecularly imprinted fluorescence sensor (MIFs) incorporates fluorescent materials (fluorescein or fluorescent nanoparticles) into a molecularly imprinted polymer synthesis system and transforms the binding sites between target molecules and molecularly imprinted materials into readable fluorescence signals. This sensor demonstrates the advantages of high sensitivity and selectivity of fluorescence detection. Molecularly imprinted materials demonstrate considerable research significance and broad application prospects. They are a research hotspot in the field of food and environment safety sensing analysis. In this study, the progress in the construction and application of MIFs was reviewed with emphasis on the preparation principle, detection methods, and molecular recognition mechanism. The applications of MIFs in food and environment safety detection in recent years were summarized, and the research trends and development prospects of MIFs were discussed.
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Zhang, Xin, Bo Tang, Yansong Li, Chengbin Liu, Pengfei Jiao, and Yuping Wei. "Molecularly Imprinted Magnetic Fluorescent Nanocomposite-Based Sensor for Selective Detection of Lysozyme." Nanomaterials 11, no. 6 (2021): 1575. http://dx.doi.org/10.3390/nano11061575.

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A new strategy for the design and construction of molecularly imprinted magnetic fluorescent nanocomposite-based-sensor is proposed. This multifunctional nanocomposite exhibits the necessary optics, magnetism and biocompatibility for use in the selective fluorescence detection of lysozyme. The magnetic fluorescent nanocomposites are prepared by combining carboxyl- functionalized Fe3O4 magnetic nanoparticles with l-cysteine-modified zinc sulfide quantum dots (MNP/QDs). Surface molecular imprinting technology was employed to coat the lysozyme molecularly imprinted polymer (MIP) layer on the MNP/QDs to form a core-shell structure. The molecularly imprinted MNP/QDs (MNP/QD@MIPs) can rapidly separate the target protein and then use fluorescence sensing to detect the protein; this reduces the background interference, and the selectivity and sensitivity of the detection are improved. The molecularly imprinted MNP/QDs sensor presented good linearity over a lysozyme concentration range from 0.2 to 2.0 μM and a detection limit of 4.53 × 10−3 μM for lysozyme. The imprinting factor of the MNP/QD@MIPs was 4.12, and the selectivity coefficient ranged from 3.19 to 3.85. Furthermore, the MNP/QD@MIPs sensor was applied to detect of lysozyme in human urine and egg white samples with recoveries of 95.40–103.33%. Experimental results showed that the prepared MNP/QD@MIPs has potential for selective magnetic separation and fluorescence sensing of target proteins in biological samples.
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Almotiri, Reim A., Kathryn J. Ham, Vineeth M. Vijayan, and Shane A. Catledge. "Molecularly Imprinted Polyacrylamide with Fluorescent Nanodiamond for Creatinine Detection." Materials 12, no. 13 (2019): 2097. http://dx.doi.org/10.3390/ma12132097.

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Creatinine measurement in blood and urine is an important diagnostic test for assessing kidney health. In this study, a molecularly imprinted polymer was obtained by incorporating fluorescent nanodiamond into a creatinine-imprinted polyacrylamide hydrogel. The quenching of peak nanodiamond fluorescence was significantly higher in the creatinine-imprinted polymer compared to the non-imprinted polymer, indicative of higher creatinine affinity in the imprinted polymer. Fourier transform infrared spectroscopy and microscopic imaging was used to investigate the nature of chemical bonding and distribution of nanodiamonds inside the hydrogel network. Nanodiamonds bind strongly to the hydrogel network, but as aggregates with average particle diameter of 3.4 ± 1.8 µm and 3.1 ± 1.9 µm for the non-imprinted and molecularly imprinted polymer, respectively. Nanodiamond fluorescence from nitrogen-vacancy color centers (NV− and NV0) was also used to detect creatinine based on nanodiamond-creatinine surface charge interaction. Results show a 15% decrease of NV−/NV0 emission ratio for the creatinine-imprinted polymer compared to the non-imprinted polymer, and are explained in terms of changes in the near-surface band structure of diamond with addition of creatinine. With further improvement of sensor design to better disperse nanodiamond within the hydrogel, fluorescent sensing from nitrogen-vacancy centers is expected to yield higher sensitivity with a longer range (Coulombic) interaction to imprinted sites than that for a sensor based on acceptor/donor resonance energy transfer.
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Li, Ke, Min Zhang, Xingyu Ye, et al. "Highly sensitive and selective detection of naproxen via molecularly imprinted carbon dots as a fluorescent sensor." RSC Advances 11, no. 46 (2021): 29073–79. http://dx.doi.org/10.1039/d1ra04817a.

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A highly selective fluorescent sensor for naproxen utilizes carbon dots as the fluorophore and molecularly imprinted polymer to provide the recognition sites. The fluorescence of carbon dots can be selectively quenched by naproxen.
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Wang, Xiaohui, Chang Liu, Yichuan Cao, Lin Cai, Haiyang Wang, and Guozhen Fang. "A Turn-Off Fluorescent Biomimetic Sensor Based on a Molecularly Imprinted Polymer-Coated Amino-Functionalized Zirconium (IV) Metal–Organic Framework for the Ultrasensitive and Selective Detection of Trace Oxytetracycline in Milk." Foods 12, no. 11 (2023): 2255. http://dx.doi.org/10.3390/foods12112255.

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Developing sensitive and effective methods to monitor oxytetracycline residues in food is of great significance for maintaining public health. Herein, a fluorescent sensor (NH2-UIO-66 (Zr)@MIP) based on a molecularly imprinted polymer-coated amino-functionalized zirconium (IV) metal–organic framework was successfully constructed and first used for the ultrasensitive determination of oxytetracycline. NH2-UIO-66 (Zr), with a maximum emission wavelength of 455 nm under 350 nm excitation, was prepared using a microwave-assisted heating method. The NH2-UIO-66 (Zr)@MIP sensor with specific recognition sites for oxytetracycline was then acquired by modifying a molecularly imprinted polymer on the surface of NH2-UIO-66 (Zr). The introduction of NH2-UIO-66 (Zr) as both a signal tag and supporter can strengthen the sensitivity of the fluorescence sensor. Thanks to the combination of the unique characteristics of the molecularly imprinted polymer and NH2-UIO-66 (Zr), the prepared sensor not only exhibited a sensitive fluorescence response, specific identification capabilities and a high selectivity for oxytetracycline, but also showed good fluorescence stability, satisfactory precision and reproducibility. The fabricated sensor displayed a fluorescent linear quenching in the OTC concentration range of 0.05–40 μg mL−1, with a detection limit of 0.012 μg mL−1. More importantly, the fluorescence sensor was finally applied for the detection of oxytetracycline in milk, and the results were comparable to those obtained using the HPLC approach. Hence, the NH2-UIO-66 (Zr)@MIP sensor possesses great application potential for the accurate evaluation of trace oxytetracycline in dairy products.
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Jalili, Roghayeh, and Mohammad Amjadi. "Surface molecular imprinting on silane-functionalized carbon dots for selective recognition of nifedipine." RSC Advances 5, no. 90 (2015): 74084–90. http://dx.doi.org/10.1039/c5ra12189b.

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Li, Qianjin, Tripta Kamra, and Lei Ye. "A modular approach for assembling turn-on fluorescence sensors using molecularly imprinted nanoparticles." Chemical Communications 52, no. 82 (2016): 12237–40. http://dx.doi.org/10.1039/c6cc06628c.

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Combining straightforward molecular imprinting with orthogonal click chemistry and accessible fluorescent dyes, a modular approach has been developed to assemble turn-on optical sensors based on fluorescence resonance energy transfer in molecularly imprinted nanoparticles.
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Ren, Baixiang, Huan Qi, Xiuying Li, et al. "A novel fluorescent functional monomer as the recognition element in core–shell imprinted sensors responding to concentration of 2,4,6-trichlorophenol." RSC Advances 8, no. 11 (2018): 6083–89. http://dx.doi.org/10.1039/c7ra07742d.

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Zhang, Xin, Meng Wang, Yating Zhang, et al. "Preparation of Molecularly Imprinted Cysteine Modified Zinc Sulfide Quantum Dots Based Sensor for Rapid Detection of Dopamine Hydrochloride." Molecules 28, no. 9 (2023): 3646. http://dx.doi.org/10.3390/molecules28093646.

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By combining surface molecular imprinting technology with cysteine-modified ZnS quantum dots, an elegant, molecularly imprinted cysteine-modified Mn2+: ZnS QDs (MIP@ZnS QDs) based fluorescence sensor was successfully developed. The constructed fluorescence sensor is based on a molecularly imprinted polymer (MIP) coated on the surface cysteine-modified ZnS quantum dots and used for rapid fluorescence detection of dopamine hydrochloride. The MIP@ZnS quantum dots possess the advantages of rapid response, high sensitivity, and selectivity for the detection of dopamine hydrochloride molecules. Experimental results show that the adsorption equilibrium time of MIP@ZnS QDs for dopamine hydrochloride molecules is 12 min, and it can selectively capture and bind dopamine in the sample with an imprinting factor of 29.5. The fluorescence quenching of MIP@ZnS QDs has a good linear (R2 = 0.9936) with the concentration of dopamine hydrochloride ranged from 0.01 to 1.0 μM, and the limit of detection is 3.6 nM. In addition, The MIP@ZnS QDs demonstrate good recyclability and stability and are successfully employed for detection of dopamine hydrochloride in urine samples with recoveries was 95.2% to 103.8%. The proposed MIP@ZnS QDs based fluorescent sensor provides a promising approach for food safety detection and drug analysis.
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Zhang, Jinna, Haiyang Wang, Longhua Xu, and Zhixiang Xu. "A semi-covalent molecularly imprinted fluorescent sensor for highly specific recognition and optosensing of bisphenol A." Analytical Methods 13, no. 1 (2021): 133–40. http://dx.doi.org/10.1039/d0ay01822h.

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Dissertations / Theses on the topic "Molecularly Imprinted Fluorescent Sensor"

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TOMMASINI, MARTINA. "Fluorescent Molecularly Imprinted Polymers as sensors for anticancer drugs." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2952847.

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Chemotherapy is a medical treatment mainly aimed at damaging solid and haematological tumors, by the administration of specific drugs able to target cancer cells. These drugs, however, often show many secondary effects and present variable inter-individual pharmacokinetics. Hence, the ideal optimization of the therapy would consist of continuously monitoring, in each patient, drug absorption in blood circulation, in order to adjust the daily dose regimen, decreasing therefore its side effects and improving the whole treatment. This methodology is known as Therapeutic Drug Monitoring (TDM) and requires the determination of drug concentration in various biological matrix, as blood, plasma, urine or saliva, and evaluation of these concentrations in terms of relevant clinical parameters. The main goal of TDM consists of individualization of therapeutic treatment of the patient. However, TDM application usually involves the support of specific instrumentations, as HPLC-MS or LC-MS/MS, that allow to perform an accurate and precise analysis of the samples, but they result time consuming, expensive and require trained personnel. Thanks to the recent technological developments, it is possible to miniaturize all of this, towards the design of specific Point-of-Care (POC) devices, able to perform a rapid quantification of the sample, without requirement of clinical support. The main advantages of using POC devices are portability, inexpensiveness and easiness to handle, hence to be used directly from patients themselves. This work is part of the project “Application of Advanced Nanotechnology in the development of innovative cancer diagnostic tools”, funded by Associazione Italiana Ricerca Cancro (AIRC) and coordinated by Centro di Riferimento Oncologico di Aviano (CRO); one of its aims consists of the development of Point-of-Care devices to be used for the Therapeutic Drug Monitoring of several anticancer drugs, included irinotecan and imatinib. This thesis project is focused, in particular, on the development of artificial receptors, named Molecularly Imprinted Polymers (MIPs), that can act as sensors for antitumor agents irinotecan and imatinib detection in human plasma samples. MIPs have been prepared by incorporating various fluorescent functional monomers in the polymer matrix, in order to obtain a fluorescent sensor, acting as recognition element and transducer at the same time. Different fluorescent 1,8-naphtalimide and a polymerisable EDANS derivatives have been synthesized; the interactions of these monomers and of fluorescein O-acrylate (commercially available) with each anticancer drug were investigated through NMR experiments. After selection of the best monomer-drug match, several MIPs have been prepared for each target molecule, following a high dilution radical polymerization protocol, and characterized by Dynamic Laser Light Scattering (DLS) and Transmission Electron Microscopy (TEM); nanoparticles with an average diameter of 15 nm were obtained. The MIPs rebinding capacity and specificity were studied through HPLC assays in water, and, exploiting their intrinsic fluorescence properties, it was possible to investigate on their rebinding capabilities in different media, by observing the eventual quenching of fluorescence upon binding. A MIP designed for irinotecan, in particular, containing a naphtalimide fluorescent dye, showed very promising results, as best specificity in water and an optimal drug sensitivity within its therapeutic concentrations range (17 nM – 17 μM), also in samples of plasma treated with acetonitrile (LOD 9.4 nM with within-run variability 10% and day to day variability 13%). The bes MIP for imatinib, instead, was obtained by incorporation of EDANS fluorophore in the polymerix matrix; at fluorescence measurements, MIP showed both a good specificity and rebinding capacity toward the imatinib in water (LOD of 1.7 μM and within-run variability 4.4%).
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Wan, Wei. "Molecularly imprinted chromogenic and fluorogenic receptors as optical sensor matrix." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2015. http://dx.doi.org/10.18452/17261.

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Diese Dissertation befasste sich mit der Entwicklung von optischen Sensormaterialien für anionische Zielmoleküle durch die Kopplung der herausragenden Erkennungsfähigkeiten von molekular geprägten Polymere (molecularly imprinted polymers, MIPs) mit der Empfindlichkeit fluorometrischer Nachweisverfahren. In dieser Arbeit wurde dabei der direkte Einschritt-Nachweis für das Design der Sensormaterialien adaptiert. Hierbei wird eine Fluoreszenzsonde für die Signalübertragung kovalent in die Hohlräume der MIP-Matrix eingebaut. MIP-Sensormaterialien wurde in monolithischen, Dünnfilm- und Kern/Schale-Partikel-Formaten hergestellt. Die hergestellten Materialien wurden unter Verwendung unterschiedlicher Techniken charakterisiert. Die Performanz der Sensormaterialien wurde auch in Bezug auf die Sensitivität, Selektivität sowie Ansprechzeit bewertet. In dieser Arbeit wurden dabei Systeme untersucht, bei denen die Signalerzeugung sowohl auf dem „Einschalten“ als auch auf dem „Ausschalten“ der Fluoreszenz beruhte. Mit den hergestellten Materialien wurden dabei viele Ziele des Projekts erreicht. Sowohl die synthetisierten dünnen Filme als auch die Kern/Schale-Partikel zeigten eine hohe Selektivität für die geprägten Aminosäuren, auch in Bezug auf die Unterscheidung von Enantiomeren. Diese Sensormaterialien waren ebenfalls durch eine niedrige Nachweisgrenze bis 60 µM und eine schnelle Ansprechzeit von 20 Sekunden gekennzeichnet. Insbesondere die Kern/Schale-Partikel können mit verschiedenen Detektionstechniken gekoppelt werden und sind potentiell für die Entwicklung von miniaturisierten Messinstrumenten für die on-line-Detektion sowie Point-of-Care-Diagnostik (patientennahe Labordiagnostik) einsetzbar.<br>This dissertation derives from the DFG project aimed on preparing optical sensor material for anionic target through combing the outstanding recognition of Molecularly imprinted polymer (MIPs) and sensitive fluorescence technique. A single step direct sensing strategy is adopted to prepare the sensor material in this thesis. Here, a fluorescence probe is covalently embedded into the MIP cavity for signal transduction. MIP sensor material are prepared in forms of bulk, thin film and particles. The material is characterized using various techniques. The performance of the sensor materials is also assessed in terms of sensibility, selectivity as well response time. Both the switching on and off signaling methods are tested in this thesis. The prepared material achieves the goal of the project. Both the prepared thin film as well as core-shell particle show prominent selectivity even a strong enantioselective discrimination. These sensing materials also have low LOD to 60 µM and fast sensing response of 20 seconds. Especially the core-shell sensing particle can be coupled with various detection techniques and is potentially applicable for developing miniaturized sensing instrument for on-line detection as well as point of care diagnose.
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Wagner, Sabine. "Sensory molecularly imprinted polymer (MIP) coatings for nanoparticle- and fiber optic-based assays." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19808.

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Für den Nachweis dieser Schadstoffe in niedrigen Konzentrationsbereichen sind schnelle und empfindliche Analysemethoden erforderlich. Molekular geprägte Polymere (MIPs) wurden als synthetische Materialien entwickelt, um die molekulare Erkennung von natürlichen Rezeptoren nachzuahmen, aufgrund ihrer Fähigkeit, selektiv eine Vielzahl von Analyten zu erkennen, ihre Stabilität und ihrer einfachen Herstellung. Sie sind zunehmend in der chemischen Sensorik als Rezeptormaterial für den Nachweis bestimmter Analyten bei niedrigen Konzentrationen zu finden, insbesondere in Kombination mit Fluoreszenz aufgrund dessen hoher Empfindlichkeit. Ziel dieser Arbeit war die Entwicklung von optischen Sensormaterialien unter Verwendung von MIPs als Erkennungselemente im Zusammenhang mit Fluoreszenz zum sensitiven Nachweis von Herbiziden und Antibiotika in Wasser- und Lebensmittelproben and deren Kombination mit verschiedenen Vorrichtungsformaten für die zukünftige Detektion einer breiten Palette von wichtigen Analyten.<br>For the detection of these contaminants in low concentration ranges fast and sensitive analytical tools are required. Molecularly imprinted polymers (MIPs) have been used as synthetic materials mimicking molecular recognition by natural receptors due to their ability to recognize selectively a wide range of analytes, their stability and ease of synthesis. They have gained more and more attention in chemical sensing as receptor material for the detection of suitable groups of analytes at low concentrations especially in combination with fluorescence due to the latter’s high sensitivity. This work aimed the development of optical sensor materials using MIPs as recognition elements connected with fluorescence for the sensitive detection of herbicides and antibiotics in water and food samples and their combination with various device formats for the future detection of a wide range of analytes.
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Ton, Xuan-Anh. "Fiber optic chemical sensors based on molecularly imprinted polymers for the detection of mycotoxins." Phd thesis, Université de Technologie de Compiègne, 2013. http://tel.archives-ouvertes.fr/tel-01002117.

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This thesis describes the development of highly selective fiber optic sensors using molecularly imprinted polymers (MIPs) as recognition elements associated with fluorescence for detection. Additionally, we extended the study to the development of other MIP-based optical sensors and sensing methods. MIPs are synthetic biomimetic receptors possessing specific cavities designed for a target molecule. Produced by a templating process at the molecular level, MIPs are capable of recognizingand binding target molecules with selectivities and affinities comparable to those of natural receptors. Compared to biological recognition elements, MIPs are more stable, cheaper and easier to integrate into standard industrial fabrication processes. Hence, MIPs have become interesting alternatives to biomolecules as recognition elements for biosensing. In the first part of this thesis (Chapter 2), MIPs were synthesized by in-situ laser-induced photopolymerization in only a few seconds, as a micrometer-sized tip at the extremity of a telecommunication optical fiber. Photonic and physico-chemical parameters were optimized to tailor the properties of the polymer micro-objects. Gold nanoparticles were incorporated into the MIP microtip for signal enhancement. To prove the efficiency of the sensor, initial studies were performed with a MIP templated with N-carbobenzyloxy-L-phenylalanine (Z-L-Phe) and the fluorescent amino acid derivative dansyl-L-phenylalanine as analyte. The fluorescence was collected either externally at the tip level by an optical fiber connected to a spectrofluorimeter or by collection of the fluorescent signal re-emitted into the fiber through the second arm of a Y-shaped bifurcated fiber. The fluorescent analyte could be detected in the low nM concentrations. In order to monitor nonfluorescent analytes, a naphthalimide-based fluorescent monomer was incorporated into the MIP during its synthesis; fluorescence enhancement was observed when analyte binding occurs. Using this system, the sensor containing a MIP specific for the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), could detect and quantify this analyte at concentrations as low as 2.5 nM. The signaling MIP-based sensor was also applied to analytes of interest for food safety and biomedical applications, such as the mycotoxin citrinin and the sphingolipid, D-erythro-sphingosine-1-phosphate. In the second part of the thesis (Chapter 3), a different type of fiber optic sensor: cheap, fast and made for "single-use", was developed by using 4-cm long disposable polystyrene evanescent wave optical fiber waveguides. The coating of the MIP was either performed ex-situ, by dip-coating the fiber in a suspension of MIP particles synthesized beforehand, or in-situ by evanescent-wave photopolymerization directly on the fiber. The resulting fiber optic sensor could detect 2,4-D in the low nM range and demonstrated specific and selective recognition of the herbicide over its structural analogues and other non-related carboxyl-containing analytes. Additionally, we demonstrated the versatility of the system by applying the evanescent wave fiber optic sensor to detect citrinin, a mycotoxin, by simply coating the waveguide with a MIP specific for citrinin. This type of technology could possibly be extended to detect other carboxyl-containing analytes, as long as a specific MIP for the concerned analyte is available. In parallel, the technique of evanescent-wave photopolymerization was used for the synthesis of signaling MIP microdots on continuous and nanostructured gold films. This study lays the foundations for future development of plasmonic MIP nanosensors and microchips. In the last part of the thesis (Chapter 4), an innovative sensing method, based on the use of MIPs and analysis by fluorescence polarization, was developed in order to allow the fast and directquantification of analytes in food and environmental samples.
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Hunt, Claire Elizabeth. "New Applications For Molecularly Imprinted Polymers in Fluorescence Assays and Sensors." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485778.

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Molecular imprinting is a technique used for the construction of synthetic polymers containing binding sites which have a high and selective affinity for a target molecule. Molecularly imprinted polymers (MIPs) can be used in sensors, to bind an analyte and then generate a signal, or in competitive binding assays, where an analyte and a probe molecule compete for .binding to a limited number of binding sites. (MIPs) are often termed 'antibody mimics', although clear advantages of MIPs are apparent when they are used in place of antibodies. MIPs are more stable and robust, inexpensive to produce and can be stored dry at room temperature for substantial periods of time. The development of MIP technologies is also desirable because their production does not require the sacrifice of animals, which is necessary for the generation of antibodies. Methods which could be employed to assess the binding of an analyte to a MIP directly in solution without needing to separate the polymer from solution have been developed, detecting the binding of the drug (S)-propranolol to MIPs, by an increase in fluorescence anisotropy in toluene, or by a shift in the peak fluorescence emission wavelength of (S)-propranolol in aqueous buffer. These methods were used to show that a (S)-propranolol imprinted polymer bound (S)-propranolol more strongly than it did (R)-propranolol, and more strongly than a non-imprinted polymer did. These methods would be particularly useful for rapidly comparing the binding properties of a number of polymers, e.g. where libraries of polymers are being screened to find the one that binds (S)-propranolol most strongly or Joost selectively. The development of competitive binding assays which do not require a time consuming separation step and which do not involve undesirable radiolabels has also been attempted. A fluorescence polarisation immunoassay and a fluorescence intensity based immunoassay for the pesticide 2,4-D were developed. These assays represent a significant advance over previously reporte,d MIP-immunoassays because they use a non-radiolabelled probe and do not .. . . require separation of the polymer from solution. The assay in buffer could be used in the field as a quick screen for 2,4-D related pesticides in contaminated water supplies. It was also attempted to develop MIPs containing a fluorescent acrylarnidofluorescein reporter group as sensors f~r (-)-ephedrine or (S)-propranolol. The binding of analyte to the polymers resulted in an increase in fluorescence, due to deprotonation of the fluorescein moiety. Fluorescence detection methods have shown potential for MIP screening libraries, and MIPs . have been shown to be viable replacements for antibodies in sensor and immunoassay applications.
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Ntshongontshi, Nomaphelo. "Molecularly imprinted polymer sensor systems for environmental estrogenic endocrine disrupting chemicals." University of the Western Cape, 2018. http://hdl.handle.net/11394/6241.

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Philosophiae Doctor - PhD (Chemistry)<br>There is growing concern on endocrine disrupting compounds (EDCs). The presence of drugs in water supplies was first realized in Germany in the early 1990s when environmental scientists discovered clofibric acid. Clofibric acid has the ability to lower cholesterol in ground water below a water treatment plant. Endocrine disrupting compounds can be defined as those chemicals with the ability to alter daily functioning of the endocrine system in living organisms. There are numerous molecules that are regarded or referred to as EDCs such as but not limited to organochlorinated pesticides, industrial chemicals, plastics and plasticizers, fuels, estrogens and many other chemicals that are found in the environment or are in widespread use. 17?- estradiol is the principal estrogen found in mammals during reproductive years. Estriol is produced in large quantities during pregnancy. 17?-estradiol is the strongest, estriol the weakest. Estriol is water soluble, estrone and estradiol are not. Although estrogen is produced in women they are also at risk of over exposure to estrogen. Pesticides are extensively used today in agricultural settings to prevent and control pests. Various pesticides, including banned organochlorines (OCs) and modern non-persistent pesticides, have shown the ability to disrupt thyroid activity, disturbing the homeostasis of the thyroid system. Because these EDCs have adverse effects on health of both human and wildlife, it is imperative to develop viable costeffective analytical methods for the detection of these EDCs in complicated samples and at very low concentrations. Very high selectivity towards particular compounds is a very important property for the suitability of a detection method. This is because these compounds mostly coexist in complex matrices which makes the detection of a specific compound very challenging. It is paramount to develop highly sensitive and selective methods for the detection of these estrogens and phosphoric acid-based pesticides at trace levels.<br>2021-08-31
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Guerra, Maria Romero. "Development of molecularly imprinted polymers for drugs of abuse and sensor applications." Thesis, Cranfield University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443743.

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Turner, Nicholas W. "Development of a molecularly imprinted polymer specific for ochratoxin A : theoretical and sensor applications." Thesis, Cranfield University, 2004. http://dspace.lib.cranfield.ac.uk/handle/1826/7584.

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In this work the development of two molecularly imprinted polymers, specific for ochratoxin A, is presented. Ochratoxin A is produced by several Aspergillus and Penicillium species and is common in cereals and other starch rich foods and has also been found in coffee, dried fruits, wine, beer and meats. It demonstrates potent teratogenic, immunosuppressive, mutagenic and carcinogenic properties. The toxin is also linked to Balkan Endemic Nephropathy, a chronic kidney disease found in South-Eastern Europe. Due to this the European Union has set limits on foodstuffs ranging between 2-10 ng g-1. Therefore the requirement of a simple and inexpensive biosensor to monitor this legislation is a necessity. Currently detection is performed by chromatographic methods such as HPLC, and by ELISA formats. In this work two polymeric materials, rationally designed by computational modelling and synthesised using molecular imprinting, are studied. The modelling is complimented with a Nuclear Magnetic Resonance (NMR) study. The first polymer (Polymer A) consisted of 1 mol of acrylamide and 1 mol of methacrylic acid to 1 mol of template. This material demonstrated an unusual binding mechanism, working solely in aqueous solvents. A theoretical mechanism for this binding is presented and discussed. The second polymer, again rationally designed, but under different conditions, consisted of 1 mol of N,N- diethylamino ethyl methacrylate (DEAEM) to 1 mol of template. This polymer demonstrated high affinity for the template in acetonitrile. Polymer A is used in combination with an ion-exchange SPE protocol (developed for this purpose) for the extraction of OTA from maize. Both polymer compositions are used in development of a MIP membrane optical sensor, with partial success seen in the detection of OTA in grape juice and white wine.
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PELLIZZONI, ELENA. "Molecularly imprinted polymeric nanoparticles for the therapeutic drug monitoring of anticancer drugs." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2907991.

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La chemoterapia consiste nell’impiego di uno o di una combinazione di farmaci antitumorali per il trattamento del cancro. Tuttavia tali farmaci sono caratterizzati da una famacocinetica molto variabile e da una elevata tossicità che porta alla comparsa di molti effetti indesiderati nei pazienti, diminuendo l’efficienza della terapia. In questo contesto l’impiego del “Therapeutic Drug Monitoring” (TDM) risulta particolarmente importante in quanto permette per lo sviluppo di terapie personalizzate per i pazienti aumentando l’efficienza della terapia e la qualità della vita dei pazienti. Questo progetto è finalizzato alla sintesi e allo sviluppo di sensori, basati su nanoparticelle polimeriche ad impronta molecolare, per i farmaci antitumorali: sunitinib, paclitaxel, SN38 e irinotecano, suo profarmaco. Tali nanoparticelle solubili sono state ottenute mediante polimerizzazione radicalica ad elevata diluizione utilizzando diversi monomeri funzionali: N-acriloil-tirosina metil estere, N-acriloil triptofano metil estere, 4-vinilpiridina e 7-acrilossicumarina. La reazione è stata effettuata lasciando interagire i monomeri funzionali e il farmaco mediante interazioni deboli (legami idrogeno, π-staking, interazioni di Van der Waals) in DMSO e dopo l’aggiunta dell’acrilamide come co-monomero, dell’N,N’-etilenebisacrilamide come crosslinker e dell’iniziatore radicalico azobisisobitironitrile (AIBN) la polimerizzazione è stata ottenuta scaldando a 70°C per 4 giorni. La molecola templato è stata rimossa mediante dialisi prima in una miscela di metanolo e acido acetico, e poi in acqua. Le particelle ottenute dopo liofilizzazione, sono state caratterizzate mediante 1H-NMR, Nanosigh e Dynamic Laser Ligh Scattering. La capacità di legame e la selettività dei polimeri è stata studiata mediante test di recupero utilizzando un metodo HPLC per la quantificazione del farmaco catturato. Mentre le proprietà fluorescenti di alcuni dei polimeri sintetizzati sono state utilizzate per studiare le affinità di legame dei polimeri a basse concentrazioni di farmaco. Il polimero contenente cumarina e specifico per il sunitinib è stato utilizzato come sensore fluorescente per lo sviluppo di un test di validazione in DMSO:plasma. Il sensore ha mostrato un’accuratezza del 15%, una precisione del 10% e una buona robustezza. Inoltre due diversi sensori fluorescenti sono stati sviluppati per la quantificazione dell’irinotecano in metanolo:plasma. Il primo sensore si basa sul quenching della fluorescenza intrinseca dell’irinotecano, mentre il secondo è un polimero molto fluorescente contenente un monomero funzionale con un gruppo naftalimidico la cui fluorescenza è spenta in seguito all’interazione con l’irinotecano. Inoltre un test fluorimetrico e colorimetrico è stato sviluppato per quantificare il paclitaxel mediante la tecnica del “dye displacement”. Il test infatti, si basa sulla competizione tra il farmaco libero ed il farmaco legato covalentemente al DABCYL per il legame ad un polimero ad imprinting molecolare contenente EDANS come monomero funzionale fluorescente. Infatti il DABCYL è sia un colorante rosso, sia un FRET quencher dell’EDANS, perciò il suo legame nel polimero porta ad una variazione del colore e della fluorescenza del polimero. Infine un test colorimetrico per la quantificazione dell’irinotecano è stato sviluppato utilizzando un polimero ad imprinting molecolare contenente l’acido 2-acrilamido-2-metil propansolfonico come monomero funzionale. Il test si basa sul legame del colorante: anilina gialla nei siti di legame del polimero rimasti liberi dopo interazione con i campioni di farmaco. L’interazione tra il colorante e l’acido solfonico nel polimero genera un cambio di colore da giallo a rosso.<br>Chemotherapy consists in cancer treatment by the administration of a single or a combination of anticancer drugs. However chemotherapy agents are often characterized by an high variability of pharmacokinetic among patients and an high toxicity that leads to the appearance of many side effects decreasing the therapy efficiency. Therefore the therapeutic drug monitoring (TDM) become useful to develop personalized therapies for patients in order to increase the efficiency of the therapy and patient compliance. This project is aimed on the synthesis and development of specific sensors based on molecularly imprinted polymeric nanoparticles, to be applied in TDM of the anticancer drugs: sunitinib, paclitaxel, SN38 and its prodrug irinotecan. Soluble nanoparticles were obtained by high dilution radical polymerization with different functional monomers: N-acryloyl-tyrosine methyl ester, N-acryloyl-tryptophan methyl ester, 4-vinyl pyridine or 7-acryloyloxy-coumarin. The reactions were carried out allowing the functional monomer to interact with the drug by weak interactions (H-bonds, -staking and Van der Waals) in DMSO and after the addition of the co-monomer acrylamide, the crosslinker N,N’-ethylene bisacrylamide, and the radical initiator azobisisobutyronitrile (AIBN) the polymerization was achieved heating at 70°C for 4 days. The template was removed by dialysis first in methanol:acetic acid mixture and after in water. After the freeze-drying the polymers were characterized by 1H-NMR, Nanosight, and Dynamic Laser Light Scattering. The polymers binding capabilities and selectivity were investigated by rebinding tests using an HPLC method for the quantification of drug captured. while the fluorescence properties of some of these polymers were exploited to study the polymers binding affinities at low drug concentrations. The polymer containing coumarin and imprinted with sunitinib was used as fluorescence sensor to set up a validation test in DMSO:plasma mixture. The system showed an accuracy of 15%, a precision of 10% and a good robustness. Two different fluorescence sensors were also developed for irinotecan able to quantify the drug in methanol:plasma mixtures. The first sensor is based on the quenching of the intrinsic fluorescence of irinotecan, while the second is an highly fluorescence polymer containing a functional monomer with a naphthalimide mojety whose fluorescence is quenched upon interaction with the drug. Moreover the dye displacement technique was used to set up a fluorescent and colorimetric test for paclitaxel quantification. The test is based on the competition between the free paclitaxel and the drug covalently linked to DABCYL dye, for the binding in to an imprinted polymer containing EDANS fluorescent functional monomer. Since DABCYL is both a red dye and a FRET quencher of EDANS, its binding into the polymer gives a change in the polymer fluorescence and colour. Finally a colorimetric test for irinotecan quantification was developed using an imprinted polymer containing 2-acrylamido-2-methylpropane sulfonic acid as functional monomer. The test is based on the binding of aniline yellow dye in to the remaining free binding sites of the polymer after treatment with drug samples. The interaction between the dye and the sulfonic acid in to the polymer gives a change of colour from yellow to red.
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Krstulja, Aleksandra. "Development of molecularly imprinted polymers for the recognition of urinary nucleoside cancer biomarkers." Thesis, Orléans, 2015. http://www.theses.fr/2015ORLE2009.

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Ce rapport de thèse présente l’étude de la technologie des empreintes moléculaires pour le développement de polymères spécifiques et sélectifs envers des biomarqueurs urinaires nucléosidiques du cancer colorectal chez l’Homme. L’objectif principal était de développer des polymères à empreintes moléculaires compatibles aux milieux aqueux en utilisant la technique du « dummy template », l’approche non-covalente and la polymérisation radicalaire en masse. Nous nous sommes concentrés principalement sur la qualité des polymères à partir de leur formulation, c’est-à-dire la spécificité et la sélectivité. Cela a été mené de façon empirique d’abord par la production de poudres issues de polymères monolithiques. Ainsi, pour atteindre les objectifs fixés, nous avons exploré le choix de la molécule « template ». Une étude de modèle est présentée au chapitre 3, en utilisant trois nucléosides 2’,3’,5’-peracétylés comme molécule empreinte dans une approche « dummy template ». Ensuite, en s’appuyant sur la connaissance apportée par le chapitre 3, nous avons développé des polymères à empreintes moléculaires (MIPs) sélectifs de la pseudouridine et de la N7-méthylguanosine dans les chapitres 4 et 5, respectivement, en utilisant la 2’,3’,5’-tri-O-acétylpseudouridine et la 2’,3’,5’-tri-O-acétylguanosine comme templates. L’étude de la rétention des nucléosides recherchés et de leurs analogues structuraux menée par chromatographie en phase liquide et par analyse frontale a permis de déterminer la capacité des différents polymères et de connaître leur comportement dans de l’urine synthétique. Finalement, pour évaluer la possible application de ces polymères dans un échantillon réel, l’urine humaine, la technique de l’extraction sur phase solide à empreintes moléculaires ou MISPE a été développée. Ainsi, une purification sélective des biomarqueurs cibles, tels que la pseudouridine et la N7-méthylguanosine, dans des échantillons d’urines a pu être démontrée<br>This thesis report presents the exploration of molecularly imprinted polymer (MIP) technology for developing of a sensitive and selective polymers used in urinary nucleoside biomarker recognition. The main goal was to develop water compatible MIPs prepared by a “dummy template” imprinting technology, using a non-covalent approach and radical-polymerization in bulk. We were focusing mostly on the polymer quality in the formulation (rigidity, stability and repeatability). This was chosen empirically first by production of powders from monolithic MIP. Thus, to accomplish the stated goals, we have explored the choice of the template molecule. A model study presented by Chapter 3, using three 2’3’5’-tri-Operacylateduridine nucleosides as templates in a “dummy” template approach was first developed. Then, applying the knowledge of the type of template choice, we developed a selective MIP for recognition of pseudouridine and N7-methylguanosine in the studies presented in Chapter 4 and Chapter 5 respectively. By using 2’3’5’-tri-O-acetylpseudouridine and 2’3’5’-tri-O-acetylguanosine as templates. Chromatographic methods like HPLC retention and frontal analysis were used in the interest of determining the binding capacity of synthesized polymers, and the behavior in synthetic urine. Finally, to evaluate the possible application of these polymers in urine, molecularly imprinted solid phase extraction (MISPE) was developed. Selective purification of urine samples containing pseudouridine and N7-methylguanosine obtained in the end
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Book chapters on the topic "Molecularly Imprinted Fluorescent Sensor"

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Gawlitza, Kornelia, Wei Wan, Sabine Wagner, and Knut Rurack. "Fluorescent Molecularly Imprinted Polymers." In Advanced Molecularly Imprinting Materials. John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119336181.ch3.

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Zhang, Huiqi. "Water-Compatible Fluorescent Molecularly Imprinted Polymers." In Molecularly Imprinted Polymers. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1629-1_8.

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Çimen, Duygu, Nilay Bereli, Fatma Kartal, and Adil Denizli. "Molecularly Imprinted Polymer-Based Quartz Crystal Sensor for the of." In Molecularly Imprinted Polymers. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1629-1_18.

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Jiang, Shan, Kornelia Gawlitza, and Knut Rurack. "Dual-Fluorescent Nanoparticle Probes Consisting of a Carbon Nanodot Core and a Molecularly Imprinted Polymer Shell." In Molecularly Imprinted Polymers. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1629-1_17.

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Yaman, Yavuz Orhan, Necdet Başaran, Kübra Karayagiz, et al. "Molecularly Imprinted Materials for Fiber-optic Sensor Platforms." In Advanced Molecularly Imprinting Materials. John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119336181.ch6.

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Li, Ping, William J. Richardson, Di Song, and Ken D. Shimizu. "CHAPTER 14. Molecularly Imprinted Polymer Sensor Arrays." In Polymer Chemistry Series. Royal Society of Chemistry, 2018. http://dx.doi.org/10.1039/9781788010474-00447.

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Okan, Meltem, and Memed Duman. "Development of Molecularly Imprinted Polymer-based Microcantilever Sensor System." In Advanced Molecularly Imprinting Materials. John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119336181.ch15.

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Tiwari, Mahavir Prasad, and Bhim Bali Prasad. "Molecularly Imprinted Polymer as Advanced Material for Development of Enantioselective Sensing Devices." In Advanced Sensor and Detection Materials. John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118774038.ch4.

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Pesavento, Maria, Simone Marchetti, Luigi Zeni, and Nunzio Cennamo. "A Molecularly Imprinted Polymer on a Novel Surface Plasmon Resonance Sensor." In Lecture Notes in Electrical Engineering. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-04324-7_33.

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Tan, Jin, and Xiu-Ping Yan. "Discrimination of Analytes with Fluorescent Molecular Imprinting Sensor Arrays." In Molecularly Imprinted Sensors. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-444-56331-6.00007-4.

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Conference papers on the topic "Molecularly Imprinted Fluorescent Sensor"

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Biyikal, M., W. Wan, K. Rurack, R. Wagner, and B. Sellergren. "3.2 - Enantioselective Fluorescence Response of Molecularly Imprinted Polymers (MIPs) toward Carbobenzyloxy- (Cbz) protected Amino Acids." In 11. Dresdner Sensor-Symposium 2013. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, Germany, 2013. http://dx.doi.org/10.5162/11dss2013/3.2.

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barsbay, murat, and MASOOMEH MEHRNIA. "Development of molecularly-imprinted fluorescent fabric based sensor system for the recognition of a model azo-dye molecule." In 2nd International Online-Conference on Nanomaterials. MDPI, 2020. http://dx.doi.org/10.3390/iocn2020-07937.

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Wren, Stephen P., Sergey A. Piletsky, Kal Karim, et al. "Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor." In OFS2014 23rd International Conference on Optical Fiber Sensors, edited by José M. López-Higuera, Julian D. C. Jones, Manuel López-Amo, and José L. Santos. SPIE, 2014. http://dx.doi.org/10.1117/12.2059278.

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Ali, Mohd Faizall, Faizatul Shimal Mehamod, and Nor Nadiah Mohamad Yusof. "Utilizing fluorescein methacrylate as fluorescent functional monomer on synthesizing fluorescent molecularly imprinted polymer in sensing caffeine." In DISRUPTIVE INNOVATION IN MECHANICAL ENGINEERING FOR INDUSTRY COMPETITIVENESS: Proceedings of the 3rd International Conference on Mechanical Engineering (ICOME 2017). Author(s), 2018. http://dx.doi.org/10.1063/1.5047199.

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Moreno-Bondi, María C., Javier L. Urraca, Elena Benito-Peña, et al. "Molecularly imprinted polymers as biomimetic receptors for fluorescence-based optical sensors." In Third European Workshop on Optical Fibre Sensors. SPIE, 2007. http://dx.doi.org/10.1117/12.738347.

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Braga, Guilherme S., and Fernando J. Fonseca. "Molecularly imprinted sensor for isoborneol based on multilayered thin films of imprinted TiO2 nanoparticles." In 2017 ISOCS/IEEE International Symposium on Olfaction and Electronic Nose (ISOEN). IEEE, 2017. http://dx.doi.org/10.1109/isoen.2017.7968863.

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Fuchs, Yannick, Xuan-Anh Ton, Karsten Haupt, Ihab Dika, Olivier Soppera, and Andrew Mayes. "Photopolymerization and photostructuring of molecularly imprinted polymers for sensor applications." In 2012 IEEE Sensors. IEEE, 2012. http://dx.doi.org/10.1109/icsens.2012.6411425.

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Braga, Guilherme S., Leonardo G. Paterno, Fernando J. Fonseca, Manel del Valle, and Perena Gouma. "Molecularly Imprinted Polymer Based Sensor for the Detection of Theophylline." In OLFACTION AND ELECTRONIC NOSE: PROCEEDINGS OF THE 14TH INTERNATIONAL SYMPOSIUM ON OLFACTION AND ELECTRONIC NOSE. AIP, 2011. http://dx.doi.org/10.1063/1.3651655.

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Shrivastav, Anand M., and Banshi D. Gupta. "Molecularly Imprinted Fiber Optic SPR Sensor for Parathion Methyl Detection." In Frontiers in Optics. OSA, 2015. http://dx.doi.org/10.1364/fio.2015.jw2a.19.

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Lebal, N., H. Hallil, C. Dejous, et al. "Nucleosides analogs recognition by molecularly imprinted polymer- coated love wave sensor." In 2013 Symposium on Microelectronics Technology and Devices (SBMicro). IEEE, 2013. http://dx.doi.org/10.1109/sbmicro.2013.6676128.

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Reports on the topic "Molecularly Imprinted Fluorescent Sensor"

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Holthoff, Ellen L., Lily Li, Tobias Hiller, and Kimberly L. Turner. A Molecularly Imprinted Polymer (MIP)-Coated Microbeam MEMS Sensor for Chemical Detection. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada622335.

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Glasscott, Matthew, Johanna Jernberg, Erik Alberts, and Lee Moores. Toward the electrochemical detection of 2,4-dinitroanisole (DNAN) and pentaerythritol tetranitrate (PETN). Engineer Research and Development Center (U.S.), 2022. http://dx.doi.org/10.21079/11681/43826.

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Analytical methods to rapidly detect explosive compounds with high precision are paramount for applications ranging from national security to environmental remediation. This report demonstrates two proof-of-concept electroanalytical methods for the quantification of 2,4-dinitroanisol (DNAN) and pentaerythritol tetranitrate (PETN). For the first time, DNAN reduction was analyzed and compared at a bare graphitic carbon electrode, a polyaniline-modified (PANI) electrode, and a molecularly imprinted polymer (MIP) electrode utilizing PANI to explore the effect of surface-area and preconcentration affinity on the analytical response. Since some explosive compounds such as PETN are not appreciably soluble in water (&lt;10 μg/L), necessitating a different solvent system to permit direct detection via electrochemical reduction. A 1,2-dichloroethane system was explored as a possibility by generating a liquid-liquid extraction-based sensor exploiting the immiscibility of 1,2-dichloroethane and water. The reduction process was explored using a scan rate analysis to extract a diffusion coefficient of 6.67 x 10⁻⁶ cm/s, in agreement with literature values for similarly structured nitrate esters. Once further refined, these techniques may be extended to other explosives and combined with portable electrochemical hardware to bring real-time chemical information to soldiers and citizens alike.
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