Relevant bibliographies by topics / Molecule probe

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Molecule probe'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Molecule probe.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Molecule probe"

1

Metfies, Katja, and Linda K. Medlin. "Feasibility of Transferring Fluorescent In Situ Hybridization Probes to an 18S rRNA Gene Phylochip and Mapping of Signal Intensities." Applied and Environmental Microbiology 74, no. 9 (March 7, 2008): 2814–21. http://dx.doi.org/10.1128/aem.02122-07.

Full text
Abstract:
ABSTRACT DNA microarray technology offers the possibility to analyze microbial communities without cultivation, thus benefiting biodiversity studies. We developed a DNA phylochip to assess phytoplankton diversity and transferred 18S rRNA probes from dot blot or fluorescent in situ hybridization (FISH) analyses to a microarray format. Similar studies with 16S rRNA probes have been done determined that in order to achieve a signal on the microarray, the 16S rRNA molecule had to be fragmented, or PCR amplicons had to be <150 bp in length to minimize the formation of a secondary structure in the molecule so that the probe could bind to the target site. We found different results with the 18S rRNA molecule. Four out of 12 FISH probes exhibited false-negative signals on the microarray; eight exhibited strong but variable signals using full-length 18S RNA molecules. A systematic investigation of the probe's accessibility to the 18S rRNA gene was made using Prymenisum parvum as the target. Fourteen additional probes identical to this target covered the regions not tested with existing FISH probes. Probes with a binding site in the first 900 bp of the gene generated positive signals. Six out of nine probes binding in the last 900 bp of the gene produced no signal. Our results suggest that although secondary structure affected probe binding, the effect is not the same for the 18S rRNA gene and the 16S rRNA gene. For the 16S rRNA gene, the secondary structure is stronger in the first half of the molecule, whereas in the 18S rRNA gene, the last half of the molecule is critical. Probe-binding sites within 18S rRNA gene molecules are important for the probe design for DNA phylochips because signal intensity appears to be correlated with the secondary structure at the binding site in this molecule. If probes are designed from the first half of the 18S rRNA molecule, then full-length 18S rRNA molecules can be used in the hybridization on the chip, avoiding the fragmentation and the necessity for the short PCR amplicons that are associated with using the 16S rRNA molecule. Thus, the 18S rRNA molecule is a more attractive molecule for use in environmental studies where some level of quantification is desired. Target size was a minor problem, whereas for 16S rRNA molecules target size rather than probe site was important.
APA, Harvard, Vancouver, ISO, and other styles
2

Long, Fei, Bin Cao, Ashok Khanal, Shiyue Fang, and Reza Shahbazian-Yassar. "Modification of a single-molecule AFM probe with highly defined surface functionality." Beilstein Journal of Nanotechnology 5 (November 14, 2014): 2122–28. http://dx.doi.org/10.3762/bjnano.5.221.

Full text
Abstract:
Single-molecule force spectroscopy with an atomic force microscope has been widely used to study inter- and intramolecular interactions. To obtain data consistent with single molecular events, a well-defined method is critical to limit the number of molecules at the apex of an AFM probe to one or to a few. In this paper, we demonstrate an easy method for single-molecule probe modification by using the Cu-catalyzed alkyne–azide cycloaddition reaction. Excess terminal alkynes were covalently attached to the probe, and a bi-functional molecule containing an azide at one end and a carboxylic acid at the other was dissolved in the reaction solution. By simply contacting the probe and the Cu substrate, controlled carboxylation on the probe apex could be achieved, since the ‘click’ reaction requires the co-exist of alkyne, azide and Cu(I). The finite contact area would result in a highly defined surface functionality of the probe down to single molecule level with high reproducibility.
APA, Harvard, Vancouver, ISO, and other styles
3

Deniz, Ashok A., Samrat Mukhopadhyay, and Edward A. Lemke. "Single-molecule biophysics: at the interface of biology, physics and chemistry." Journal of The Royal Society Interface 5, no. 18 (May 22, 2007): 15–45. http://dx.doi.org/10.1098/rsif.2007.1021.

Full text
Abstract:
Single-molecule methods have matured into powerful and popular tools to probe the complex behaviour of biological molecules, due to their unique abilities to probe molecular structure, dynamics and function, unhindered by the averaging inherent in ensemble experiments. This review presents an overview of the burgeoning field of single-molecule biophysics, discussing key highlights and selected examples from its genesis to our projections for its future. Following brief introductions to a few popular single-molecule fluorescence and manipulation methods, we discuss novel insights gained from single-molecule studies in key biological areas ranging from biological folding to experiments performed in vivo .
APA, Harvard, Vancouver, ISO, and other styles
4

Wang, Jun, and Da Hai Ren. "Synthesis and Detection Experiments of a Biomolecule Detection Probe Based on Fluorescence Changes." Advanced Materials Research 998-999 (July 2014): 336–39. http://dx.doi.org/10.4028/www.scientific.net/amr.998-999.336.

Full text
Abstract:
The sensitivity of fluorescence probes built upon the resonance energy transfer is not high enough at present. We built a fluorescence probe with high sensitivity (SA-488-sub-nanogold) by means of the fluorochrome Alexa488 (SA-488) labeled by streptavidin, nanogold, and biotin-subpeptide. When the fluorescence molecule SA-488 binds with the nanogold by biotin-subpeptide, the fluorescence intensity will be suppressed because of resonance energy transfer. If there are molecules under test, the energy transfer will be blocked, by which we can get the molecule content from the fluorescence intensity. Using this probe, we acquired a lower detection limit and a higher sensitivity for biotin detection.
APA, Harvard, Vancouver, ISO, and other styles
5

Zhang, Song Bai, Pei Zhen Han, Ping Lu, Xia Hu, Li Ying Zheng, Xue Wen Liu, Guang Yu Shen, Ji Lin Lu, Li Ping Qiu, and Shi Biao Zhou. "Reusable Electrochemical Aptasensor for Sensitive Detection of Small Molecules Based on Structure-Switching Hairpin Probe." Advanced Materials Research 791-793 (September 2013): 988–91. http://dx.doi.org/10.4028/www.scientific.net/amr.791-793.988.

Full text
Abstract:
A reusable electrochemical biosensing strategy based on structure-switching hairpin probe for the detection of small molecules is proposed using cocaine as the model analyte. Aptamer probe hybridized with the immobilized signal probe to form DNA duplex. When target small molecule was added, competition between target molecule and the signal probe with the aptamer probe happened, which induced the signal probe from stretched duplex to hairpin structure. By measuring ac current voltammetry, the target molecule can be sensitively detected in a linear dynamic range from 1 nM-1000 nM with a low detection limit of 0.7 nM. In particular, the biosensor can be easily regenerated by melting in hot water, making it reusable.
APA, Harvard, Vancouver, ISO, and other styles
6

Gruszka, Dominika T. "Biochemistry: one molecule at a time." Essays in Biochemistry 65, no. 1 (April 2021): 1–3. http://dx.doi.org/10.1042/ebc20210015.

Full text
Abstract:
Abstract Biological processes are orchestrated by complex networks of molecules. Conventional approaches for studying the action of biomolecules operate on a population level, averaging out any inhomogeneities within the ensemble. Investigating one biological macromolecule at a time allows researchers to directly probe individual behaviours, and thus characterise the intrinsic molecular heterogeneity of the system. Single-molecule methods have unravelled unexpected modes of action for many seemingly well-characterised biomolecules and often proved instrumental in understanding the intricate mechanistic basis of biological processes. This collection of reviews aims to showcase how single-molecule techniques can be used to address important biological questions and to inspire biochemists to ‘zoom in’ to the population and probe individual molecular behaviours, beyond the ensemble average. Furthermore, this issue of Essays in Biochemistry is the very first written and edited entirely by early career researchers, and so it also highlights the strength, diversity and excellence of the younger generation single-molecule scientists who drive this exciting field of research forward.
APA, Harvard, Vancouver, ISO, and other styles
7

Chen, Weizhi, Baozhong Shen, and Xilin Sun. "Analysis of Progress and Challenges of EGFR-Targeted Molecular Imaging in Cancer With a Focus on Affibody Molecules." Molecular Imaging 18 (January 1, 2019): 153601211882347. http://dx.doi.org/10.1177/1536012118823473.

Full text
Abstract:
Epidermal growth factor receptor (EGFR)-targeted cancer therapy requires an accurate estimation of EGFR expression in tumors to identify responsive patients, monitor therapeutic effect, and estimate prognosis. The EGFR molecular imaging is an optimal method for evaluating EGFR expression in vivo accurately and noninvasively. In this review, we discuss the recent advances in EGFR-targeted molecular imaging in cancer, with a special focus on the development of imaging agents, including epidermal growth factor (EGF) ligand, monoclonal antibodies, antibody fragments, Affibody, and small molecules. Each substrate or probe, whether it is an endogenous ligand, antibody, peptide, or small molecule labeled with fluorochrome or radionuclide, has unique advantages and limitations. Antibody-based probes have high affinity but a long metabolic cycle and therefore offer poor imaging quality. Affibody molecules promise to surpass antibody-based probes due to their small size, stable chemical properties, and high affinity to the target. Small-molecule probes are safe, have favorable pharmacokinetics, and show high affinity and specificity, in addition to having an ideal size, but are inadequate for delayed imaging after injection due to their fast clearance.
APA, Harvard, Vancouver, ISO, and other styles
8

Kamp, Marlous, Bart de Nijs, Nuttawut Kongsuwan, Matthias Saba, Rohit Chikkaraddy, Charlie A. Readman, William M. Deacon, et al. "Cascaded nanooptics to probe microsecond atomic-scale phenomena." Proceedings of the National Academy of Sciences 117, no. 26 (June 15, 2020): 14819–26. http://dx.doi.org/10.1073/pnas.1920091117.

Full text
Abstract:
Plasmonic nanostructures can focus light far below the diffraction limit, and the nearly thousandfold field enhancements obtained routinely enable few- and single-molecule detection. However, for processes happening on the molecular scale to be tracked with any relevant time resolution, the emission strengths need to be well beyond what current plasmonic devices provide. Here, we develop hybrid nanostructures incorporating both refractive and plasmonic optics, by creating SiO2nanospheres fused to plasmonic nanojunctions. Drastic improvements in Raman efficiencies are consistently achieved, with (single-wavelength) emissions reaching 107counts⋅mW−1⋅s−1and 5 × 105counts∙mW−1∙s−1∙molecule−1, for enhancement factors >1011. We demonstrate that such high efficiencies indeed enable tracking of single gold atoms and molecules with 17-µs time resolution, more than a thousandfold improvement over conventional high-performance plasmonic devices. Moreover, the obtained (integrated) megahertz count rates rival (even exceed) those of luminescent sources such as single-dye molecules and quantum dots, without bleaching or blinking.
APA, Harvard, Vancouver, ISO, and other styles
9

Fu, Yanhua, and Nathaniel S. Finney. "Small-molecule fluorescent probes and their design." RSC Advances 8, no. 51 (2018): 29051–61. http://dx.doi.org/10.1039/c8ra02297f.

Full text
Abstract:
Small-molecule fluorescent probes allow light to be used as a tool to advance the study of biology, discover new drugs, and further the detection of cancer. This tutorial review introduces important concepts related to fluorescent probe development.
APA, Harvard, Vancouver, ISO, and other styles
10

Diana, Rosita, Ugo Caruso, Angela Tuzi, and Barbara Panunzi. "A Highly Water-Soluble Fluorescent and Colorimetric pH Probe." Crystals 10, no. 2 (February 3, 2020): 83. http://dx.doi.org/10.3390/cryst10020083.

Full text
Abstract:
A new 5-(4-((2-(benzothiazole-2-carbonyl)hydrazono)methyl)-3-hydroxyphenoxy)-N,N,N-trimethylpentan-1-aminium bromide (BTABr) fluorescent and colorimetric pH probe was easily synthesized by the condensation reaction of benzothiazole-2-carbohydrazide with 5-(4-formyl-3-hydroxyphenoxy)-N,N,N-trimethylpentan-1-aminium bromide. The benzothiazole moiety provided the emissive part of the molecule and the charged trimethyl amino group guaranteed outstanding solubility in water, for an organic molecule. pH titration experiments indicated that the probe is useful for monitoring acidic and alkaline solutions, turning reversibly in color/fluorescence just at a neutral pH value. Naked-eye colorimetric response was observed both in solution and in the solid state. In addition, the probe showed high stability and selectivity and large Stokes shifts. Because of these features, BTABr can potentially work as an on-off real-time pH sensor for intracellular pH imaging. The crystal structure of BTABr examined by single-crystal analysis showed a planar geometry of the molecule and confirmed the presence of a molecular stacking between molecules joined in a complex tridimensional hydrogen bonding pattern.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Molecule probe"

1

Inverarity, Iain Andrew. "Marked small molecule libraries : a new approach to molecular probe design." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/14147.

Full text
Abstract:
This thesis documents a new approach for the identification of a small biologically active molecule’s site of interaction, through the rapid synthesis of molecular probes. A marked library approach has been developed whereby a biocompatible marker is attached onto the small molecule’s molecular scaffold. This marker plays no role in the screening process itself, but facilitates the formation of a range of molecular probes from active marked library members. As an example of molecular probe formation, site selective biotinylation will be discussed in the introduction. This marked library concept has been applied to the natural product anisomycin A. Investigations focused on development of a detailed structure activity relationship for anisomycin’s activation of the stress activated protein kinase (SAPK) pathway, along with the synthesis of a number of marked library analogues. The active marked library members were then converted to a range of functional molecular probes utilising the copper(I) catalysed Huisgen cycloaddition as the key coupling step. These molecular probes are being used in the elucidation of anisomycin’s biological target for activation of the SAPK pathway. In a further demonstration of this strategy, a focused library of marked steroids has been synthesised based on the functionalisation of dehydroepiandrosterone B. Directed by the results of preliminary biological screening, a number of marked library members have been converted into fluorescent molecular probes. These probes will be used in future applications to probe the biological action of the dehydroepiandrosterone.
APA, Harvard, Vancouver, ISO, and other styles
2

Forshaw, Paula Louise. "Kinetic studies of probe molecule adsorption on activated carbons." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324940.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Taylor, Christopher George. "Novel fluorescence techniques to probe protein aggregation." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/276197.

Full text
Abstract:
The self-assembly of amyloidogenic proteins to form cytotoxic species that give rise to brain deterioration underlies numerous neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Increasing evidence indicates that it is the rare, low-molecular-weight species (oligomers) rather than the more abundant high-molecular-weight fibrils of certain proteins that are the most cytotoxic in several neurodegenerative diseases. However, these species have proven difficult to study using traditional methods due to their transient nature and the heterogeneity of aggregation mixtures. In this thesis, I describe my work to develop advanced methods where I combine single-molecule and ensemble fluorescence techniques with microfluidic strategies to enable the study of protein aggregation, spanning small, transient oligomers to large, insoluble aggregates. In Chapter 1 I give an overview of the biological context and relevance of this work, including the background of neurodegenerative disease, amyloidogenic aggregation and key proteins involved. I then briefly review fluorescence microscopy techniques and the field of microfluidics. In Chapter 2 I describe how complex microfluidics can be integrated with single-molecule confocal techniques to provide a highly sensitive method to continuously probe protein aggregation in vitro. I show, for the first time, that the dilution of aggregating mixtures may be automated, by up to five orders of magnitude, down to the picomolar concentrations suitable for single-molecule measurements. By incorporating this microfluidic dilution device I greatly improve the temporal resolution of the technique and facilitate the observation of more transient species through the ability to rapidly dilute and take fluorescence measurements of samples. In Chapter 3 I overcome the need for in situ labels to monitor amyloidogenic aggregation using single-molecule confocal microscopy. I describe my work to adapt the single-molecule confocal technique to achieve the ultrasensitive detection of individual aggregate species under flow without covalently-attached labels. I have demonstrated the ability of this new method to monitor the aggregation of label-free amyloidogenic proteins using extrinsic labels ex-aggregation, opening the way for biological samples to be probed in a high-throughput manner. In Chapter 4 I describe my work to combine the high precision of confocal microscopy with a microfluidic device developed to directly characterise the sizes and interactions of biomolecules in the continuous phase. By monitoring the spatial and temporal mass transport on the micron scale, the diffusion coefficient, and thus hydrodynamic radius, of species may be determined. The technique delivers much greater sensitivity for size quantification, allowing scarce and other challenging samples to be characterised, and provides significant steps towards accurate sizing for single-molecule aggregation experiments under flow. In Chapter 5 I describe my work to determine the microscopic driving force for the spatial propagation of amyloid-beta. The epifluorescence instrument I built has enabled the proliferation of aggregate species to be monitored over a macro distance on a timescale of minutes. This has greatly improved the scope of the experimental data attained, which will be used in conjunction with Monte Carlo simulations to deliver a model for the propagation of amyloid-beta in vitro. Together this thesis represents my work developing the above novel fluorescence techniques to improve their temporal and size resolution, sensitivity and adaptability to study highly complex and fundamental protein aggregation linked to neurodegenerative disease.
APA, Harvard, Vancouver, ISO, and other styles
4

Adhikari, Subhasis, and Frank Cichos. "Probe size dependent rotational dynamics in polymer by single molecule spectroscopy." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-185732.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Pawlosky, Annalisa M. (Annalisa Marie). "Single molecule techniques to probe decision-making processes in developmental biology." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/87503.

Full text
Abstract:
Thesis: Ph. D., Harvard-MIT Program in Health Sciences and Technology, 2014.
Cataloged from PDF version of thesis.
Includes bibliographical references.
This work investigates the fundamental processes used by mammalian cells and organisms to make decisions during embryonic development. Current technologies that evaluate biological phenomenon often force a compromise between quantification of gene expression via bulk assays and qualitative imaging of cell and tissue heterogeneity. There are few options that allow for quantitative, high-resolution, single-cell analysis that is robust but not associated with a high degree of technical difficulty or obscured by amplification. Here, we address these issues using two model systems, the developing mammalian inner ear and single mouse embryonic stem cells (mESCs) during the process of X inactivation, to demonstrate our ability to perform single-cell, single-molecule assays that reveal both highly quantitative and spatial information. Accordingly, we adapted a high resolution, single-molecule RNA fluorescent in situ hybridization technique (smFISH) to study gene expression in the inner ear and perform allele-specific detection of the X chromosome in mESCs. We used previously-published smFISH procedures as our initial template for investigating biological signaling phenomena in these two systems. To study gene expression in the mouse inner ear, we developed a modified smFISH strategy to investigate mRNA transcript expression patterns in the cochlea during auditory hair cell development. The mammalian cochlea, a highly specialized and complex organ, beautifully demonstrates both the depth and breadth of the smFISH technique. To assay signaling behavior and topological changes of the X chromosome prior to X inactivation, we incorporated a novel allele-specific modification into the smFISH technique. We investigate the allele-specific expression patterns of eight genes that tile the X chromosome, which were chosen for their varied putative roles before, during and after X chromosome inactivation. Taken together, these two systems recapitulate the strength of the smFISH technique and its adaptations. The goals of this thesis were twofold: (1) expand the smFISH technique to work in specialized mammalian systems such as the cochlea and (2) demonstrate allele-specific DNA topological changes and expression patterns in mESCs. Elucidating high-resolution, single-molecule quantifiable imaging methods for application to complex tissues or allele-specific probing will have profound impacts on future investigations and promote a deeper comprehension of these systems.
by Annalisa M. Pawlosky.
Ph. D.
APA, Harvard, Vancouver, ISO, and other styles
6

Adhikari, Subhasis, and Frank Cichos. "Probe size dependent rotational dynamics in polymer by single molecule spectroscopy." Diffusion fundamentals 16 (2011) 77, S. 1-2, 2011. https://ul.qucosa.de/id/qucosa%3A13821.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Egleton, James Edward. "Small molecule colorimetric and fluorescent probes for specific protein detection." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:0a1a1c80-8055-491a-920a-3e17f7919e93.

Full text
Abstract:
This thesis describes the design, synthesis, analysis, mechanistic evaluation and optimisation of small molecule probes for the specific detection of proteins, focusing on the target protein human arylamine N-acetyltransferase type 1 (HUMAN(NAT1)) and its murine homologue, mouse arylamine N-acetyltransferase type 2 (MOUSE(NAT2)). The HUMAN(NAT1) gene is reported to be one of the most highly overexpressed genes in estrogen-receptor-positive (ER+) breast tumours, leading to its potential use as both a novel diagnostic biomarker and a novel therapeutic target for this disease. Chapter 1 reviews the literature on optical methods for the specific detection of a protein target, exploring strategies both based on biosensors and on chemical probes, before introducing the arylamine N-acetyltransferases as a family of enzymes. In Chapter 2, a family of naphthoquinone inhibitors of HUMAN(NAT1) are introduced, which undergo a colour change from red to blue upon binding specifically to the enzyme. The mechanism of this colour change, a proton transfer-mediated process, is discussed via the synthesis, pharmacological and colorimetric evaluation of close analogues of the hit compound lacking a key acidic sulfonamide-NH proton. During these studies, it was found that direct O-methylation of a sulfonamide is possible under certain conditions; such a reaction has not previously been reported. Furthermore, upon heating in polar solvents the O-methylated sulfonamide was observed to undergo rearrangement, and the mechanism of this process is investigated via NMR and kinetic studies. In Chapter 3, the design, synthesis and evaluation of HUMAN(NAT1) inhibitors with improved pharmacological and colorimetric profiles over the initial hit are described. From this optimisation, structure-activity relationships and an in silico model of interactions between the inhibitors and enzyme are evaluated. Testing of these compounds in cellular environments, however, exposes some limitations of this approach, notably the lack of sensitivity of the probes when dosed at low concentrations in cellular samples. In order to overcome this limitation, in Chapter 4 fluorescent analogues of the hit compound are designed and synthesised. Initial compounds developed in this series possess promising properties, but each compound generated suffers from either a low fluorescent intensity, lack of a pH-dependent switch in fluorescence or a low fluorescence excitation wavelength, which overlaps with those of tryptophan or tyrosine residues in proteins. Insights into the mechanism of molecular fluorescence and application of some simple quantum mechanical principles, however, lead to the design of a species which possesses all the required properties. The fluorescent emission intensity of this probe correlates linearly with [MOUSE(NAT2)] in E. coli cell extracts, and can quantify as little as 0.64% MOUSE(NAT2) in the samples; furthermore, the probe is capable of unambiguously detecting HUMAN(NAT1) within a cell extract from the ER+ breast cancer cell line ZR-75-1; future work on this probe may therefore enable its clinical use in improved early diagnosis of breast tumours. This study also represents, to the best of our knowledge, the first ever example of a small molecule, non-covalent probe capable of quantifying the concentration of a target protein in cellular extracts. In Chapter 5, the series of naphthoquinone probes is further optimised in order to study the roles of HUMAN(NAT1) in a cellular environment. Firstly, structure-activity relationships are utilised to design inhibitors with improved physical properties such as aqueous solubility and cell membrane permeability, in order to test the effect of HUMAN(NAT1) inhibitors in tumour cell models, which could have implications for the future use of a HUMAN(NAT1) inhibitor as a therapeutic agent in oncology. Secondly, the effect of the cofactor folic acid on the function and activity of HUMAN(NAT1) is explored. Finally, in Chapter 6, the conclusions of this study are outlined and a hypothesis as to how the concepts developed in this thesis might be applied to alternative, more ubiquitous biological targets is discussed, paving the way for future investigations.
APA, Harvard, Vancouver, ISO, and other styles
8

Chen, Changsheng Verfasser], and Maximilian [Akademischer Betreuer] [Ulbrich. "Fluorescently labeled DNA probe in STORM imaging and single-molecule protein labeling." Freiburg : Universität, 2019. http://d-nb.info/1187658545/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Chen, Changsheng [Verfasser], and Maximilian [Akademischer Betreuer] Ulbrich. "Fluorescently labeled DNA probe in STORM imaging and single-molecule protein labeling." Freiburg : Universität, 2019. http://d-nb.info/1187658545/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Ericsson, Olle. "Biomolecular Analysis by Dual-Tag Microarrays and Single Molecule Amplification." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8475.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Molecule probe"

1

Schnorr, Kirsten. XUV Pump-Probe Experiments on Diatomic Molecules. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-12139-0.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Jan, Slavík. Fluorescent probes in cellular and molecular biology. Boca Raton: CRC Press, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Raghavachari, Ramesh, and Samuel Achilefu. Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications IV: 23-25 January 2012, San Francisco, California, United States. Edited by SPIE (Society). Bellingham, Wash: SPIE, 2012.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Raghavachari, Ramesh, and Samuel Achilefu. Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications V: 4-6 February 2013, San Francisco, Calififornia, United States. Edited by SPIE (Society), SPIE Photonics West (Conference) (2013 : San Francisco, Calif.), and Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (Conference) (5th : 2013 : San Francisco, Calif.). Bellingham, Washington: SPIE, 2013.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Tycko, Robert, ed. Nuclear Magnetic Resonance Probes of Molecular Dynamics. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1410-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Johnson, Iain D., and Michelle T. Z. Spence. The molecular probes handbook: A guide to fluorescent probes and labeling technologies. [Carlsbad, CA]: Live Technologies Corporation, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Krul, Kenneth G. The U.S. market for molecular diagnostics. Edited by Heffner Steven and Kalorama Information LLC. 2nd ed. New York: Kalorama Information, 2004.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Krul, Kenneth G. The U.S. market for molecular diagnostics. New York: Kalorama Information, 2001.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Min, Zhang, Yin Bin-Cheng, and SpringerLink (Online service), eds. Nano-Bio Probe Design and Its Application for Biochemical Analysis. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Marx, Andreas, and Oliver Seitz, eds. Molecular Beacons: Signalling Nucleic Acid Probes, Methods, and Protocols. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-040-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Molecule probe"

1

Jäckel, Frank, and Jürgen P. Rabe. "Scanning Tunneling Spectroscopy of Complex Molecular Architectures at Solid/Liquid Interfaces: Toward Single-Molecule Electronic Devices." In Scanning Probe Microscopies Beyond Imaging, 36–53. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2006. http://dx.doi.org/10.1002/3527608516.ch2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Tas, Roderick P., Trusanne G. A. A. Bos, and Lukas C. Kapitein. "Purification and Application of a Small Actin Probe for Single-Molecule Localization Microscopy." In Single Molecule Analysis, 155–71. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7271-5_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Kienberger, Ferry, Lilia A. Chtcheglova, Andreas Ebner, Theeraporn Puntheeranurak, Hermann J. Gruber, and Peter Hinterdorfer. "Single-Molecule Studies on Cells and Membranes Using the Atomic Force Microscope." In Applied Scanning Probe Methods VI, 101–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-37319-3_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Maksymovych, Peter. "Excitation and Mechanisms of Single Molecule Reactions in Scanning Tunneling Microscopy." In Scanning Probe Microscopy of Functional Materials, 3–37. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-7167-8_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Rutz, Soeren, Elmar Schreiber, and Ludger Wöste. "Femtosecond Pump&Probe Spectroscopy on the K2 Molecule." In Ultrafast Processes in Spectroscopy, 127–31. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-5897-2_28.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Huang, Weigang, and Qisheng Zhang. "Fluorous Photoaffinity Labeling to Probe Protein-Small Molecule Interactions." In Methods in Molecular Biology, 253–61. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2269-7_20.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Zou, Shan, Holger Schönherr, and G. Julius Vancso. "Atomic Force Microscopy-Based Single-Molecule Force Spectroscopy of Synthetic Supramolecular Dimers and Polymers." In Scanning Probe Microscopies Beyond Imaging, 315–53. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2006. http://dx.doi.org/10.1002/3527608516.ch11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Vančura, T., S. Schmitt, V. Friedli, S. Torbrügge, and O. Schaff. "On the Road to Multi-Probe Non-Contact AFM." In Advances in Atom and Single Molecule Machines, 81–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28172-3_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Radiom, Milad. "Development of Colloidal Probe Correlation Force Spectroscopy: Case Study." In Correlation Force Spectroscopy for Single Molecule Measurements, 47–62. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14048-3_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Kienberger, Ferry, Lilia A. Chtcheglova, Andreas Ebner, Theeraporn Puntheeranurak, Hermann J. Gruber, and Peter Hinterdorfer. "Single-Molecule Studies on Cells and Membranes Using the Atomic Force Microscope." In Biosystems - Investigated by Scanning Probe Microscopy, 479–503. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02405-4_17.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Molecule probe"

1

Higgins, M. J., M. Polcik, T. Fukuma, J. E. Sader, and S. P. Jarvis. "Direct Mechanical Measurement of Organised Water and the Influence of Adjacent Surface Chemistry Using Atomic Force Microscopy (Keynote)." In World Tribology Congress III. ASMEDC, 2005. http://dx.doi.org/10.1115/wtc2005-64383.

Full text
Abstract:
Directly measuring structural changes in water with a mechanical probe of lateral dimensions comparable to that of a single molecule provides an invaluable insight into how and why bio-molecules behave with high selectivity or why certain surfaces promote or inhibit bio-molecular adhesion. In the immediate vicinity of the molecule, continuum models break down and the aqueous environment will often form a discrete layered structure depending on the nature of the molecule. The absence or presence of such structure may be fundamental in influencing the promotion or inhibition of protein adsorption, biological function and membrane recognition.
APA, Harvard, Vancouver, ISO, and other styles
2

van Hulst, N. F., E. M. H. P. van Dijk, J. P. Hoogenboom, J. Hernando, and M. F. Garcia-Parajo. "Single Molecule Pump-Probe Detection on Coupled Quantum Systems." In International Conference on Ultrafast Phenomena. Washington, D.C.: OSA, 2006. http://dx.doi.org/10.1364/up.2006.fa1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Dake, Fumihiro, Naoki Fukutake, Seri Hayashi, and Yusuke Taki. "Superresolution fluorescence imaging by pump-probe setup using repetitive stimulated transition process." In Single Molecule Spectroscopy and Superresolution Imaging XI, edited by Jörg Enderlein, Ingo Gregor, Zygmunt K. Gryczynski, Rainer Erdmann, and Felix Koberling. SPIE, 2018. http://dx.doi.org/10.1117/12.2287325.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Kanezawa, M., T. Mineta, E. Makino, T. Sugawara, and S. Toh. "Electrostatic Stretching of Hyaluronic Acid Molecule and Cutting with AFM Probe." In TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference. IEEE, 2007. http://dx.doi.org/10.1109/sensor.2007.4300232.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Melnikov, A. G., and G. V. Melnikov. "Optical Sensor Based on the Protein Molecule, Comprising a Luminescent Probe." In Optical Sensors. Washington, D.C.: OSA, 2014. http://dx.doi.org/10.1364/sensors.2014.sem4c.7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Alper, Joshua, and Kimberly Hamad-Schifferli. "Biomolecular Activity Switch: An Application of Metallic Nanoparticle Plasmon Resonance and Femtosecond Pulsed Lasers." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68104.

Full text
Abstract:
With an increased effort within the engineering community to design molecular machines, it has become clear that a specific, external control method is required. Here we propose a simple mechanism for a molecular switch involving conjugating a molecule within the machinery to a gold nanorod. Then actuate that machinery’s active state by affecting a change in the conjugated molecule. We demonstrate the feasibility of the method using a fluorescent probe, and we report on progress we have made toward demonstrating it with a protein.
APA, Harvard, Vancouver, ISO, and other styles
7

Tomin, V. I., Jozef Heldt, and M. Brozis. "The model of luminescent probe molecule additionally appearing in the TICT state." In IV Workshop on Atomic and Molecular Physics, edited by Jozef Heldt. SPIE, 2003. http://dx.doi.org/10.1117/12.544567.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Haran, Gilad, P. M. Champion, and L. D. Ziegler. "Single-Molecule Raman Spectroscopy: A Probe of Charge Transfer and Plasmonic Fields." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482699.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Yamaguchi, Madoka, Masahiro Nakano, Ryosuke Senga, Hiroyuki Maruyama, Shige H. Yoshimura, and Yoshikazu Nakayama. "Specific Interaction Studied by Single-Molecule Force Measurement using a Carbon Nanotube Probe." In Biomechanics / Robotics. Calgary,AB,Canada: ACTAPRESS, 2011. http://dx.doi.org/10.2316/p.2011.751-008.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Yamaguchi, Madoka, Masahiro Nakano, Ryosuke Senga, Hiroyuki Maruyama, Shige H. Yoshimura, and Yoshikazu Nakayama. "Specific Interaction Studied by Single-Molecule Force Measurement using a Carbon Nanotube Probe." In Biomechanics / Robotics. Calgary,AB,Canada: ACTAPRESS, 2012. http://dx.doi.org/10.2316/p.2012.751-008.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Molecule probe"

1

Blackmond, D. G., I. Wender, R. Oukaci, and J. Wang. Probe molecule studies: Active species in alcohol synthesis. Office of Scientific and Technical Information (OSTI), July 1992. http://dx.doi.org/10.2172/7154553.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Blackmond, D. G., I. Wender, R. Oukaci, and J. Wang. Probe molecule studies: Active species in alcohol synthesis. Office of Scientific and Technical Information (OSTI), December 1992. http://dx.doi.org/10.2172/6758736.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Blackmond, D. G. Probe molecule studies: Active species in alcohol synthesis. Office of Scientific and Technical Information (OSTI), April 1992. http://dx.doi.org/10.2172/5100318.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Blackmond, D. G., I. Wender, R. Oukaci, and J. Wang. Probe molecule studies: Active species in alcohol synthesis. Office of Scientific and Technical Information (OSTI), October 1992. http://dx.doi.org/10.2172/6873487.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Blackmond, D. G., and I. Wender. Probe molecule studies: Active species in alcohol synthesis. Office of Scientific and Technical Information (OSTI), September 1991. http://dx.doi.org/10.2172/6128128.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Blackmond, D. G., and I. Wender. Probe molecule studies: Active species in alcohol synthesis. Office of Scientific and Technical Information (OSTI), July 1991. http://dx.doi.org/10.2172/5262741.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Blackmond, D. G. Probe molecule studies: Active species in alcohol synthesis. Office of Scientific and Technical Information (OSTI), December 1991. http://dx.doi.org/10.2172/5389426.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Blackmond, D. G., I. Wender, R. Oukaci, and Jian Wang. Probe molecule studies: Active species in alcohol synthesis. Final report, July 1993--July 1994. Office of Scientific and Technical Information (OSTI), July 1994. http://dx.doi.org/10.2172/10195883.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Blackmond, D. G. Probe molecule studies: Active species in alcohol synthesis. Fifth quarterly report, October 1991--December 1991. Office of Scientific and Technical Information (OSTI), December 1991. http://dx.doi.org/10.2172/10136137.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Blackmond, D. G., I. Wender, R. Oukaci, and Jian Wang. Probe molecule studies: Active species in alcohol synthesis. Eleventh quarterly report, April 1993--June 1993. Office of Scientific and Technical Information (OSTI), June 1993. http://dx.doi.org/10.2172/10191624.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Molecule probe' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography