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Journal articles on the topic 'Monitoring anticoagulation'

Author: Grafiati

Published: 15 June 2024

Last updated: 31 July 2025

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1

Smythe, Maureen A., and Anne Caffee. "Anticoagulation Monitoring." Journal of Pharmacy Practice 17, no. 5 (2004): 317–26. http://dx.doi.org/10.1177/0897190004271775.

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Optimal management of anticoagulant therapy requires an understanding of the laboratory tests often employed to guide therapy. The activated partial thromboplastin time (aPTT) can detect abnormalities in the intrinsic and common clotting pathways. Despite numerous limitations in the aPTT test, it remains the gold standard for monitoring unfractionated heparin and direct thrombin inhibitor therapy. The aPTT can be performed in the central laboratory or at the bedside (point of care [POC] testing). The activated clotting time (ACT) is a POC test that is routinely employed to monitor high-dose he

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2

Ng, Valerie L. "Anticoagulation Monitoring." Clinics in Laboratory Medicine 29, no. 2 (2009): 283–304. http://dx.doi.org/10.1016/j.cll.2009.05.003.

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3

Pence, Catherine, and Kimberly McErlane. "Anticoagulation Self-Monitoring." AJN, American Journal of Nursing 105, no. 10 (2005): 62–65. http://dx.doi.org/10.1097/00000446-200510000-00036.

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4

EBBERT, JON O., and ERIC G. TANGALOS. "Anticoagulation Self-Monitoring." Internal Medicine News 39, no. 20 (2006): 44. http://dx.doi.org/10.1016/s1097-8690(06)74379-7.

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5

Chandler, Wayne L. "Anticoagulation Without Monitoring." American Journal of Clinical Pathology 140, no. 5 (2013): 606–7. http://dx.doi.org/10.1309/ajcpe8cwkovg4agx.

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6

Li Wan Po, Alain. "Self-monitoring of anticoagulation." Lancet 379, no. 9828 (2012): 1788–89. http://dx.doi.org/10.1016/s0140-6736(12)60757-0.

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7

McPherson, Mary Lynn. "Home oral anticoagulation monitoring." Journal of Home Health Care Practice 4, no. 1 (1992): 63–77. http://dx.doi.org/10.1177/108482239200400110.

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8

Hambleton, Julie. "Home Monitoring of Anticoagulation." Journal of Thrombosis and Thrombolysis 16, no. 1/2 (2003): 39–42. http://dx.doi.org/10.1023/b:thro.0000014591.32012.1f.

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9

McRae, Hannah L., Leah Militello, and Majed A. Refaai. "Updates in Anticoagulation Therapy Monitoring." Biomedicines 9, no. 3 (2021): 262. http://dx.doi.org/10.3390/biomedicines9030262.

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In the past six decades, heparin and warfarin were the primary anticoagulants prescribed for treatment and prophylaxis of venous thromboembolism worldwide. This has been accompanied by extensive clinical knowledge regarding dosing, monitoring, and reversal of these anticoagulants, and the resources required to do so have largely been readily available at small and large centers alike. However, with the advent of newer oral and parenteral anticoagulants such as low molecular weight heparins, factor Xa inhibitors, and direct thrombin inhibitors in recent years, new corresponding practice guideli

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10

Maier, Cheryl L., and Roman M. Sniecinski. "Anticoagulation Monitoring for Perioperative Physicians." Anesthesiology 135, no. 4 (2021): 738–48. http://dx.doi.org/10.1097/aln.0000000000003903.

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From preoperative medications to intraoperative needs to postoperative thromboprophylaxis, anticoagulants are encountered throughout the perioperative period. This review focuses on coagulation testing clinicians utilize to monitor the effects of these medications.

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11

Calatzis, A., M. Leitner, and S. Panzer. "Monitoring anticoagulation of primary haemostasis." Hämostaseologie 29, no. 03 (2009): 279–84. http://dx.doi.org/10.1055/s-0037-1617037.

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SummaryThis article provides an overview on current commercially available methods to determine primary haemostasis as a target of drug-mediated anticoagulation. It focuses on whole blood methods only, and references the currently major achievements that have been reported with each method in respect to its clinical use. Advantages and disadvantages of the various methods are presented, based on considerations of platelet physiology, and on feasibility of the procedures.

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12

Wool, Geoffrey D., and Chuanyi M. Lu. "Pathology Consultation on Anticoagulation Monitoring." American Journal of Clinical Pathology 140, no. 5 (2013): 623–34. http://dx.doi.org/10.1309/ajcpr3jtok7nkdbj.

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13

Despotis, George J., Glenn Gravlee, Kriton Filos, Jerrold Levy, and Dennis M. Fisher. "Anticoagulation Monitoring during Cardiac Surgery." Anesthesiology 91, no. 4 (1999): 1122. http://dx.doi.org/10.1097/00000542-199910000-00031.

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The literature does not consistently support the importance of anticoagulation monitoring techniques during CPB. This is best reflected by studies that have evaluated the impact of the ACT method on blood loss and transfusion outcomes. Inconsistent findings from studies that evaluated the impact of ACT monitoring may be related to either suboptimal study design (i.e., retrospective, unblinded, nonrandomized) or possibly the diagnostic inprecision of the ACT method used in these studies. There are a small number of well-controlled studies, some of which suggest that bleeding and transfusion out

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14

Richardson, Evelyn. "Self-monitoring of oral anticoagulation." Lancet 367, no. 9508 (2006): 412. http://dx.doi.org/10.1016/s0140-6736(06)68140-3.

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15

Georgiadis, D., M. Hill, P. Zunker, F. Stögbauer, and E. B. Ringelstein. "Anticoagulation monitoring with transcranial doppler." Lancet 344, no. 8933 (1994): 1373–74. http://dx.doi.org/10.1016/s0140-6736(94)90738-2.

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16

Sarawate, Chaitanya, Mirko V. Sikirica, Vincent J. Willey, Michael F. Bullano, and Ole Hauch. "Monitoring anticoagulation in atrial fibrillation." Journal of Thrombosis and Thrombolysis 21, no. 2 (2006): 191–98. http://dx.doi.org/10.1007/s11239-006-4968-z.

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17

Bussey, Henry I. "Problems with Monitoring Heparin Anticoagulation." Pharmacotherapy 19, no. 1 (1999): 2–5. http://dx.doi.org/10.1592/phco.19.1.2.30519.

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18

Schaadt, Jennifer. "Monitoring Anticoagulation During Aprotinin Utilization." Journal of ExtraCorporeal Technology 28, no. 1 (1996): 42–47. http://dx.doi.org/10.1051/ject/199628142.

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The literature reviewed discussed the varying practices of anticoagulation measurement in those open heart patients receiving aprotinin. All references have reported an increase in celite ACTs (C-ACTs) in heparinized patients who were treated with aprotinin. Two authors attributed this effect to aprotinin's ability to enhance heparin's anticoagulation and therefore permit a decrease in the heparin dose. Other authorities proved that during aprotinin administration the C-ACTs were artificially prolonged and that the C-ACT should either be maintained at 750 seconds or greater, or not be used at

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19

Mruthunjaya, Ashwin K. V., and Angel A. J. Torriero. "Electrochemical Monitoring in Anticoagulation Therapy." Molecules 29, no. 7 (2024): 1453. http://dx.doi.org/10.3390/molecules29071453.

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The process of blood coagulation, wherein circulating blood transforms into a clot in response to an internal or external injury, is a critical physiological mechanism. Monitoring this coagulation process is vital to ensure that blood clotting neither occurs too rapidly nor too slowly. Anticoagulants, a category of medications designed to prevent and treat blood clots, require meticulous monitoring to optimise dosage, enhance clinical outcomes, and minimise adverse effects. This review article delves into the various stages of blood coagulation, explores commonly used anticoagulants and their

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20

Ferretti, Gianluigi, Diana Giannarelli, Paolo Carlini, et al. "Self-monitoring versus standard monitoring of oral anticoagulation." Thrombosis Research 119, no. 3 (2007): 389–90. http://dx.doi.org/10.1016/j.thromres.2006.08.007.

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21

Rodrigues, Ana Bento, Anabela Rodrigues, Catarina Jacinto Correia, Gustavo Nobre Jesus, and João Miguel Ribeiro. "Anticoagulation Management in V-V ECMO Patients: A Multidisciplinary Pragmatic Protocol." Journal of Clinical Medicine 13, no. 3 (2024): 719. http://dx.doi.org/10.3390/jcm13030719.

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(1) Background: Extracorporeal membrane oxygenation (ECMO) is a complex procedure affecting both the risk of thrombosis and bleeding. High-quality data to personalize anticoagulation management in ECMO are lacking, resulting in a high variability in practice among centers. For this reason, we review coagulation methods and monitoring and share a pragmatic proposal of coagulation management, as performed in our high-volume ECMO Referral Centre; (2) Methods: We revised the anticoagulation options and monitoring methods available for coagulation management in ECMO through PubMed search based on w

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22

&NA;. "Heparin concentrations useful in monitoring anticoagulation." Inpharma Weekly &NA;, no. 1072 (1997): 17. http://dx.doi.org/10.2165/00128413-199710720-00030.

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23

Hou, Xiaotong. "Anticoagulation monitoring in extracorporeal membrane oxygenation." Perfusion 36, no. 5 (2021): 438–39. http://dx.doi.org/10.1177/02676591211024090.

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24

Utley, Martin, David Patterson, and Steve Gallivan. "Monitoring the effectiveness of anticoagulation control." International Journal of Health Care Quality Assurance 18, no. 1 (2005): 7–14. http://dx.doi.org/10.1108/09526860510576929.

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25

Nguyen, Trung, Matthew Musick, and Jun Teruya. "Anticoagulation Monitoring During Extracorporeal Membrane Oxygenation." Pediatric Critical Care Medicine 15, no. 2 (2014): 178–79. http://dx.doi.org/10.1097/pcc.0000000000000039.

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26

Rose, Adam J., Donald R. Miller, Al Ozonoff, et al. "Gaps in Monitoring During Oral Anticoagulation." Chest 143, no. 3 (2013): 751–57. http://dx.doi.org/10.1378/chest.12-1119.

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27

Heneghan, C., R. Perera, and A. Ward. "Self-monitoring of anticoagulation – Authors' reply." Lancet 379, no. 9828 (2012): 1789. http://dx.doi.org/10.1016/s0140-6736(12)60758-2.

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28

Siebler, Mario, Andreas Nachtmann, Matthias Sitzer, and Helmuth Steinmetz. "Anticoagulation monitoring and cerebral microemboli detection." Lancet 344, no. 8921 (1994): 555. http://dx.doi.org/10.1016/s0140-6736(94)91953-4.

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29

Cohen, Marc. "Monitoring anticoagulation during percutaneous coronary interventions." Journal of Thrombosis and Thrombolysis 1, no. 3 (1995): 285–88. http://dx.doi.org/10.1007/bf01060738.

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30

Burnakis, Thomas G. "Another Perspective on Monitoring Anticoagulation Therapy." Annals of Pharmacotherapy 29, no. 10 (1995): 1045–46. http://dx.doi.org/10.1177/106002809502901018.

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31

Fitzmaurice, D. A., F. D. R. Hobbs, and J. A. Murray. "Monitoring oral anticoagulation in primary care." BMJ 312, no. 7044 (1996): 1431–32. http://dx.doi.org/10.1136/bmj.312.7044.1431.

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32

Gozzard, D. I., and A. Craig. "Monitoring oral anticoagulation in primary care." BMJ 313, no. 7060 (1996): 818. http://dx.doi.org/10.1136/bmj.313.7060.818b.

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33

Mittal, Prabal, Zara Sayar, and Hannah Cohen. "Warfarin and heparin monitoring in antiphospholipid syndrome." Hematology 2024, no. 1 (2024): 192–99. https://doi.org/10.1182/hematology.2024000547.

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Abstract Anticoagulation is central to the management of antiphospholipid syndrome (APS), an acquired thrombo-inflammatory disorder characterized by thrombosis (venous, arterial, or microvascular) or pregnancy morbidity, in association with persistent antiphospholipid antibodies (aPL; ie, 1 or more of lupus anticoagulant [LA], anticardiolipin, anti-beta-2- glycoprotein I, IgG, or IgM antibodies). The mainstay of anticoagulation in patients with thrombotic APS is warfarin or an alternative vitamin K antagonist (VKA) and, in certain situations, low-molecular-weight heparin (LMWH) or unfractionat

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34

Ozment, Caroline, Peta M. A. Alexander, Wayne Chandler, et al. "Anticoagulation Monitoring and Targets: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference." Pediatric Critical Care Medicine 25, no. 7 (2024): e14-e24. http://dx.doi.org/10.1097/pcc.0000000000003494.

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OBJECTIVES: To derive systematic-review informed, modified Delphi consensus regarding anticoagulation monitoring assays and target levels in pediatric extracorporeal membrane oxygenation (ECMO) for the Pediatric ECMO Anticoagulation CollaborativE. DATA SOURCES: A structured literature search was performed using PubMed, EMBASE, and Cochrane Library (CENTRAL) databases from January 1988 to May 2021. STUDY SELECTION: Anticoagulation monitoring of pediatric patients on ECMO. DATA EXTRACTION: Two authors reviewed all citations independently, with a third independent reviewer resolving any conflicts

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35

Schwaiger, Daniel, Lukas Schausberger, Benedikt Treml, et al. "Activated Clotting Time and Haemostatic Complications in Patients Receiving ECMO Support: A Systematic Review." Journal of Cardiovascular Development and Disease 12, no. 7 (2025): 267. https://doi.org/10.3390/jcdd12070267.

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Background: Extracorporeal membrane oxygenation (ECMO) requires systemic anticoagulation to prevent clotting, typically using unfractionated heparin (UFH). However, anticoagulation carries a bleeding risk, necessitating monitoring. Activated clotting time (ACT) is a commonly used monitoring tool for UFH anticoagulation. However, systematized evidence linking ACT monitoring with haemostatic complications (bleeding and thrombosis) is missing. Methods: A systematic review (Scopus and PubMed, up to 13 July 2024) including studies reporting on the patients receiving ECMO support with UFH anticoagul

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36

Diaz-Benito, Jose, and Luisa Muñoz-Garde. "QUALITY OF ANTICOAGULATION MONITORING: COMPARISON OF ANTICOAGULATION CLINIC VERSUS ROUTINE MEDICAL CARE." European Journal of Internal Medicine 22 (October 2011): S25. http://dx.doi.org/10.1016/s0953-6205(11)60101-5.

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37

Finsterer, J., C. Stöllberger, and P. Hopmeier. "Home-Made Anticoagulation Monitor vs. CoaguCheck-Plus® Monitoring of Oral Anticoagulation." Thrombosis Research 98, no. 6 (2000): 571–75. http://dx.doi.org/10.1016/s0049-3848(00)00207-3.

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38

Taylor, F., M. Ramsay, J. Voke, and H. Cohen. "Anticoagulation in patients with atrial fibrillation. GPs not prepared for monitoring anticoagulation." BMJ 307, no. 6917 (1993): 1493. http://dx.doi.org/10.1136/bmj.307.6917.1493.

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39

McFarland, Craig P., and Stuart E. Lind. "Thrombin Generation Biomarkers Decline With Parenteral Anticoagulation—An Overlooked Means of Anticoagulation Monitoring?" Clinical and Applied Thrombosis/Hemostasis 24, no. 5 (2018): 708–17. http://dx.doi.org/10.1177/1076029617746506.

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Anticoagulation therapy is administered to patients to prevent or stop thrombin generation in vivo. Although plasma tests of in vivo thrombin generation have been available for more than 2 decades, they are not routinely used in clinical trials or practice to monitor anticoagulation therapy. We observed a fall in one such marker, the D-dimer antigen, in patients receiving anticoagulation therapy. We therefore conducted a systematic review of the medical literature to document the change in serum biomarkers of thrombin generation following the initiation of anticoagulation therapy. Using a defi

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40

Zhou, Qi, Gordon Guyatt, and Pablo Alonso-Coello. "Home-monitoring of oral anticoagulation vs. dabigatran." Thrombosis and Haemostasis 108, no. 10 (2012): 647–53. http://dx.doi.org/10.1160/th12-01-0027.

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SummaryOral anticoagulation with vitamin k antagonists (VKAs) requires regular testing and dose adjustment. Home-monitoring (self-testing or self-management) is more effective than usual management. Dabigatran, does not require dose-adjustment and appears to be more effective at reducing the risk of stroke with similar risks of bleeding in patients with atrial fibrillation (AF). Dabigatran, however, has not been compared to the home-monitoring. It was the objective to evaluate the efficacy of dabigatran compared with home-monitoring of oral anticoagulation with VKAs. Randomised controlled tria

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41

Gilbert, Brian W., Jacob A. Reeder, Tessa R. Reynolds, Caitlynn A. Tabaka, and Megan A. Rech. "Anticoagulation Monitoring in the Intensive Care Unit." Critical Care Nursing Quarterly 45, no. 2 (2022): 108–18. http://dx.doi.org/10.1097/cnq.0000000000000394.

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42

Lequier, Laurance, and M. Patricia Massicotte. "Monitoring of Anticoagulation in Extracorporeal Membrane Oxygenation." Pediatric Critical Care Medicine 16, no. 1 (2015): 87–89. http://dx.doi.org/10.1097/pcc.0000000000000298.

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43

Linden, Belinda. "Self-monitoring and management of oral anticoagulation." British Journal of Cardiac Nursing 5, no. 8 (2010): 378–79. http://dx.doi.org/10.12968/bjca.2010.5.8.66246.

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44

Stoysich, Anne M., Firouzan Massoomi, Paula L. Danekas, Thomas L. Williams, and Kay L. Ryschon. "A Review of Two Anticoagulation Monitoring Devices." Journal of Pharmacy Technology 17, no. 5 (2001): 209–16. http://dx.doi.org/10.1177/875512250101700506.

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45

Szlam, F., G. Dickneite, J. H. Levy, and K. Tanaka. "Continuous thrombin generation for monitoring phenprocoumon anticoagulation." European Journal of Anaesthesiology 24, Supplement 41 (2007): 28. http://dx.doi.org/10.1097/00003643-200706003-00089.

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46

Shore-Lesserson, Linda. "Monitoring anticoagulation and hemostasis in cardiac surgery." Anesthesiology Clinics of North America 21, no. 3 (2003): 511–26. http://dx.doi.org/10.1016/s0889-8537(03)00036-1.

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47

Mccurdy, Mark. "Oral Anticoagulation Monitoring in a Community Pharmacy." American Pharmacy 33, no. 10 (1993): 61–72. http://dx.doi.org/10.1016/s0160-3450(15)30639-5.

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48

Bembea, Melania M., Jamie M. Schwartz, Nilay Shah, et al. "Anticoagulation Monitoring during Pediatric Extracorporeal Membrane Oxygenation." ASAIO Journal 59, no. 1 (2013): 63–68. http://dx.doi.org/10.1097/mat.0b013e318279854a.

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49

Hines, Michael H. "Anticoagulation Monitoring During Pediatric Extracorporeal Membrane Oxygenation." ASAIO Journal 59, no. 1 (2013): 1–2. http://dx.doi.org/10.1097/mat.0b013e31827c2615.

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50

Lewis, Clinton, and Karen Moffat. "Laboratory Monitoring of Oral Vitamin K Anticoagulation." Seminars in Thrombosis and Hemostasis 43, no. 03 (2016): 245–52. http://dx.doi.org/10.1055/s-0036-1587690.

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