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Dissertations / Theses on the topic 'Monoamine'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Mullan, Elaine L. "Inhibitors of monoamine oxidase." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337116.

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2

Kaushal, Setu. "Characterization of Three Putative Monoamine Oxidase Genes in Caenorhabditis elegans." Ohio University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1218747926.

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3

Fitzgerald, Julia. "Monoamine oxidase in neuronal cell death." Thesis, Nottingham Trent University, 2008. http://irep.ntu.ac.uk/id/eprint/51/.

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Monoamine oxidase (MAO) is an oxidative enzyme that deaminates a variety of amine substrates, including the neurotransmitter dopamine. The enzymatic reaction requires molecular oxygen and produces hydrogen peroxide as a by-product. MAO is localised in the outer mitochondrial membrane and exists as two isoforms, MAO-A and MAO-B, which are differentially expressed in the body and differ in their substrate and inhibitor specificities. Previous studies have suggested that MAO-generated reactive oxygen species (ROS) contribute to oxidative stress in the cell and can directly inhibit electron transp

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4

Stenström, Anders. "Intra- and extraneuronal monoamine oxidase (MAO)." Umeå : [University of Umeå], 1986. http://catalog.hathitrust.org/api/volumes/oclc/15239401.html.

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5

Yeomanson, K. B. "An immunochemical analysis of monoamine oxidase profiles." Thesis, Nottingham Trent University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254741.

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6

Maurel, Agnès. "Monoamine oxydases rénales et cardiaques : implications physiopathologiques." Paris 7, 2004. http://www.theses.fr/2004PA077127.

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7

Wu, Bo. "Structure-function relationships in monoamine oxidase B /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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8

Ruchala, Iwona. "EXPANDING MONOAMINE TRANSPORTERS PHARMACOLOGY USING CALCIUM CHANNELS." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5032.

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Research in drug development meets many challenges including lengthy, complex and costly procedures to identify novel pharmacotherapies. In our lab, we developed a method for fast screening of small molecules that interact with monoamine transports – dopamine and serotonin (DAT, SERT). These membrane proteins play important roles in brain neurotransmission responsible for cognition, motion and pleasure. Dysfunction in dopaminergic and serotonergic systems result in neurological disorders such as depression, Attention Deficit Hyperactivity Disorder (ADHD), schizophrenia and addiction. DAT and S

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9

Saiyudthong, Somrudee. "Mechanisms underlying the antidepressant properties of St. John's wort (Hypericum perforatum)." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275319.

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10

Backwell, Colette. "Labels for the active site of monoamine oxidase." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336043.

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11

Abdel-Razaq, Wesam. "Molecular mechanisms of monoamine neurotransmitter modulatory antidepressant actions." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435767.

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12

Jackson, Gillian. "Monoamine release and turnover in broiler chicken brain." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411086.

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13

Vince, Matthew Joseph Kline. "Examining Monoamine Oxidase Inhibitor Targets Using Caenorhabditis elegans." Ohio University Art and Sciences Honors Theses / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1598384776888279.

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14

Foka, Germaine Boulenoue. "Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease." University of the Western Cape, 2016. http://hdl.handle.net/11394/5549.

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Magister Pharmaceuticae - MPharm<br>Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language skills and other cognitive impairments to occur. The hallmarks of AD include the presence of extracellular insoluble amyloid beta plaques, intracellular neurofibrillary tangles, and the decrease in ACh concentration. The pathophysiology of AD is not well understood, however, acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and mon

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15

Booysen, Hermanus Perold. "Thiocaffeine derivatives as inhibitors of monoamine oxidase / Booysen H.P." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7348.

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Parkinson’s disease (PD) is a neurodegenerative disorder which is characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) of the brain and reduced striatal dopamine (DA). Neuropathologically, PD is characterized by the presence of intraneuronal inclusions called Lewy Bodies (LBs). While the pathogenesis of PD is unknown, it is thought that monoamine oxidase (MAO) may play an important role in the neurodegenerative process. In the basal ganglia DA is oxidized by MAO, a process which is associated with the formation of toxic metabolic by–products. For

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16

Quinn, T. G. "Characterisation of the vesicular monoamine transporters 1 and 2." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368550.

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17

Rein, Glen. "Monoamine metabolism in normal tissues and neural crest tumours." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/47814.

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18

Odhar, Hasanain. "Identification of novel scaffolds for Monoamine oxidase B inhibitors." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1394416913.

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19

Courtney, Nicholas A. "Mechanisms of Autoreceptor-Mediated Inhibition in Central Monoamine Neurons." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1447955036.

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20

Pizzinat, Nathalie. "Les monoamine oxydases renales et adipocytaire : caracterisation et regulation." Toulouse 3, 1999. http://www.theses.fr/1999TOU30005.

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Les monoamine oxydases (mao) sont des enzymes cles du catabolisme de neuromediateurs tels que la noradrenaline, la dopamine et la serotonine, et d'amines exogenes. Deux isoformes de l'enzyme, la mao-a et la mao-b, codees par deux genes distincts ont ete identifiees. Les maos sont fortement exprimees au niveau peripherique. Toutefois, l'expression relative et la fonction de chaque isoforme dans les organes presentant une importante heterogeneite morphologique tel que le rein ont ete tres peu etudiees. A ce niveau, nous avons montre que les cellules mesangiales glomerulaires de rat expriment tre

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21

Hansson, Stefan R. "The serotonin transporter and vesicular monoamine transporters during development." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945023.html.

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22

Holloway, Alexa. "Pharmacodynamics of Monoamine Transporter Releasing Agents and Reuptake Inhibitors." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5880.

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Ligands of the human monoamine transporters encompass a wide range of both illicit and therapeutic drugs that act upon neural circuitry related to reward, motivation, and the processing of salient stimuli. The present study utilizes two methods for analyzing transporter substrates and inhibitors in order to characterize activity and assess potency. The first measures transient changes in intracellular calcium as a surrogate for transporter activity by harnessing the electrical coupling of monoamine transporters and L-type calcium channels. This is used to analyze novel chimera of the strong hD

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23

Sørensen, Izel Fourie. "Influence of tobacco smoke constituents on monoamine oxidase activity in vitro and on human placental monoamine oxidase A activity in vivo / Izel Fourie Sørensen." Thesis, North-West University, 2004. http://hdl.handle.net/10394/294.

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The aim of this study was to investigate the influence of tobacco smoke on monoamine oxidase activity, and of smoking during pregnancy on placental monoamine oxidase A (MAO-A) activity. The enzyme MA0 exists in two isoforms, MAO-A and MAO-B, both of which are important in regulating monoamine status in the brain and periphery. Some substrate selectivity for particular monoamines is a characteristic of these isoforms, and one form of the enzyme may predominate in particular organs. Recreational tobacco smoking influences the status of monoamine oxidases in the body. In vivo studies using PET im

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24

Gretton, Heather Margaret. "Platelet monoamine oxidase type B (MAO-B) activity in psychopathy." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30619.

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Studies of platelet MAO-B activity have revealed a link between low platelet activity and psychiatric syndromes characterized by an inability to control impulses and to anticipate future consequences of behavior (Oreland, 1980; Gottfries, von Knorring, & Oreland, 1980). These characteristics are fundamental to the construct of psychopathy, and we might therefore expect that psychopathy is associated with low MAO activity. Indeed, some investigators have suggested that low platelet MAO-B activity is a potential marker for vulnerability to psychopathy (Schalling, Asberg, Edman, & Oreland, 1987).

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25

Mejia, Jose. "Monoamine oxidases and aggressive behaviour : clinical studies and animal models." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38238.

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Monoamine oxidases (MAOs) are phylogenetically old enzymes which catalyze the deamination of monoamines. Interest in a relationship between MAO and aggressive behaviour derives from the report of a single family with a mutation which obliterates the activity of MAO A, as well as a long history of studies which substantiate a relationship between MAO activity and impulsive aggressive behaviour. The goals of this thesis were: (1) to examine the generalizability of the specific MAO mutation noted above; (2) to evaluate the relationship between platelet MAO activity and genetic polymorphisms in MA

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26

Finch, Cheryl Christine. "An immunochemical analysis of monoamine oxidase in health and disease." Thesis, Nottingham Trent University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298903.

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27

Taylor, Julian Scott. "Opioid and monoamine modulation of spinal reflexes in the rabbit." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385277.

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28

Gibb, Celia Margaret. "Environment and neurological illness : role of monoamine oxidase and phenolsulphotransferase." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47072.

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29

Wang, Zhixia, Gregory A. Ordway, and William Woolverton. "Effects of Cocaine on Monoamine Uptake as Measured Ex Vivo." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/8611.

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The increase in extracellular dopamine (DA) following cocaine administration plays a major role in cocaine abuse. In vitro, cocaine binds to DA transporters (DAT) and blocks DA uptake. Moreover, cocaine can increase extracellular DA concentration as measured by in vivo neurochemical methods. The present study examined the effects of cocaine and other drugs on DA, NE and 5-HT uptake using an ex vivo assay. Rats were injected i.v. with saline or drug and sacrificed at various time points after injections. Brains were dissected for regional monoamine uptake studies ex vivo. In most brain regions,

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30

Coatrieux, Christelle. "Monoamine oxydases et athérosclérose : signalisation mitogène et étude in vivo." Toulouse 3, 2007. http://thesesups.ups-tlse.fr/38/.

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Les espèces réactives de l'oxygène (EROs) activent de nombreuses voies de signalisation cellulaires, comme la prolifération et sont impliquées dans l'athérosclérose. Les monoamine oxydases (MAOs), dégradent les amines biogènes, libèrant des EROs. Elles peuvent être impliquées dans la prolifération cellulaire ou l'apoptose par le stress oxydant qu'elles génèrent. Ce travail a montré que la MAO-A, en dégradant son substrat, active une voie de signalisation mitogène particulière : la voie MMP2/sphingolipides, et contribue à la prolifération de cellules musculaire lisses vasculaires. Cet effet a é

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31

Wan, Li. "Monoamine Oxidase and Sensory Gating: Psychophysiological Vulnerabilities among Teenage Smokers." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/27380.

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Smoking is one of the leading causes of death in the world. About 80% of smokers start smoking before the age of 18. In the Appalachian area and the South in the United States, smoking percentages among adults and adolescents are higher than in other regions. Female smoking shows a variety of different trends from male smoking, and smoking brings particular health problems related to production to female smokers. These findings highlighted the importance of studying female teenage smokers in southwest Virginia. The initial project aimed to identify risk factors that might prevent smoking in an

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32

Beaver, Jasmin Nicole. "BEHAVIORAL RESPONSES TO PSYCHOSTIMULANTS IN PLASMA MEMBRANE MONOAMINE DEFICIENT MICE." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent1627571055518516.

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33

Bauer, Clayton T. "Determinants of Abuse-Related Effects of Monoamine Releasers in Rats." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/522.

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Monoamine releasers constitute a class of compounds that promote release of dopamine, serotonin, and/or norepinephrine. These compounds have a range of different uses in the medical setting, including treatment of attention deficit hyperactivity disorder, narcolepsy, and obesity. A major limitation of many of these compounds (i.e. amphetamine, methamphetamine, phenmetrazine) is their propensity for abuse; however, not all monoamine releasers are abused (i.e. fenfluramine). The goal of this dissertation was to examine pharmacological determinants of abuse-related effects produced by monoamine r

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34

Peters, Jennifer Margaret 1956. "Synthesis and monoamine uptake inhibiting properties of perisubstituted tricyclic compounds." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/291828.

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The synthesis of 1-methyl-promazine, 4-hydroxymethyl-iminodibenzyl, and 4-bromo-5-trimethylsilyl-iminodibenzyl via dilithiation and ¹H-NMR's are described. Molecular modeling was done for the latter compound. The heat of dissociation was 30.6 kcal/mole for the lowest energy conformer. Rotational energies were examined for three bonds. The IC₅₀ values for inhibition of neurotransmitter uptake by rat brain synaptosomes were determined for a series of 1-substituted promazines, and 4-substituted imipramines. 1-Substituted promazines were fair inhibitors of serotonin uptake with an average IC₅₀ of

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35

Nguyen, Vy. "Analyzing Interactions Between Methcathinone Analogs and the Human Monoamine Transporters." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/6004.

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Psychostimulants elicit their psychological and behavioral effects through interactions with the monoamine transporters. These compounds are classified as either substrates or reuptake inhibitors, depending on their mechanism of action, and have varying potencies at the three human monoamine transporters, hDAT, hSERT, and hNET. Substrates and reuptake inhibitors also have distinct electrophysiological signatures: reuptake inhibitors cause hyperpolarization in HEK293 cells stably expressing the monoamine transporters, whereas substrate transport mediates a depolarizing current. Recent studies h

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36

Parboosingh, Jillian S. "Biochemical and molecular analysis of monoamine oxidase in alcoholics, high risk subjects and low risk controls." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61088.

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Alcoholism is a prevalent multifactorial disease with both genetic and environmental components. Monoamine oxidase (MAO) has been proposed as a susceptibility marker for familial alcoholism but consistent evidence of either specific MAO variants in alcoholics or allelic segregation in at-risk families has not been presented. Two structural genes on the X chromosome encode two forms of the enzyme, MAO-A and MAO-B. Kinetic constants for platelet MAO-B and restriction fragment length polymorphisms for MAO-A were determined in alcoholics with multigenerational family histories of alcoholism, high

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37

Shearman, M. S. "Pharmacological and biochemical characterisation of serotonin-5-HT2Ì² receptors from rat frontal cortex and human platelets." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377497.

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38

Sivasubramaniam, S. D. "Monoamine oxidase expression in non-CNS tissues and pregnancy-induced hypertension." Thesis, Nottingham Trent University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271798.

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Monoamine oxidase (MAO) is an outer mitochondrial membrane bound enzyme responsible for the oxidative deamination of a wide variety of biogenic and xenobiotic amines. Altered MAO activity has been reported in a number of medical and psychiatric disorders. Although the tissue distribution of these enzymes has been extensively studied, the localization of MAO proteins and mRNAs at the cellular level in peripheral tissues, including placenta, has not been fully established. In addition the status of placental MAO in pre-eclampsia - a severe disorder of pregnancy has not been fully studied, despit

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39

Repsold, Benjamin Petrus. "Inhibition of monoamine oxidase B by substituted coumarin derivatives / Bennie Repsold." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4177.

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Interest in the selective inhibition of monoamine oxidase B (MAO-B) has increased in the last years due to their therapeutic potential in age related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Reversibly inhibiting MAO-B reduces the oxidative deamination of dopamine, increases dopamine levels and, consequently, reduces the production of reactive oxygen species (ROS) which may be the therapeutic intervention that positively affect the tempo and progression of neurodegenerative diseases. Coumarin analogues exhibit a broad spectrum of pharmacological activity,

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40

Strydom, Belinda. "Inhibition of monoamine oxidase by caffeine- and phthalide analogues / Belinda Strydom." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9535.

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Monoamine oxidase (MAO) consists of two isoforms, MAO-A and MAO-B. MAO is responsible for the oxidation of neurotransmitter and dietary amines. The MAO-B isoform, in particular, is considered to be a drug target for the treatment of neurodegenerative disorders such as Parkinson’s disease (PD). Inhibition of MAO-B may conserve dopamine in the brain, resulting in symptomatic relief of PD. Furthermore, inhibition of MAO-B may prevent the formation of neurotoxic metabolic products and thus MAO-B inhibitors may exert a neuroprotective effect. For these reasons, MAO-B inhibitors have been used as an

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41

Houghton, Andrea Karen. "Peptide and monoamine modulation of a withdrawal reflex in the rabbit." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294717.

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42

Blackmore, Colin Giles. "Modulation of intravesicular pH and progastrin processing by vesicular monoamine transporters." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366674.

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43

Hansard, Matthew James. "Evaluation of monoamine reuptake inhibition in experimental models of Parkinson's disease." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399344.

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44

Paillat, Catherine. "Synthèse et pharmacologie de nouveaux inhibiteurs de la monoamine oxydase β". Paris 6, 1996. http://www.theses.fr/1996PA066653.

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Dans ce memoire sont presentees les syntheses chimiques, les etudes biochimiques et pharmacologiques de nouveaux inhibiteurs de monoamines oxydases b (mao b) et une etude structurale de celle-ci par marquage par photoaffinite. Dans une premiere partie, sont decrites les syntheses chimiques d'acetylhydrazones des derives du 4-(benzyloxy) benzaldehyde substitues en para, 3 et de composes heterocycliques : 5-aryl-2-alkyl-4-alkyl-2,4-dihydro-1,2,4-triazol-3-ones 6 et 5-aryl-2-(2-cyanoethyl)-3h-1,3,4-oxadiazol-2-(methyl)imine 5. Les etudes biochimiques in vitro ont permis de determiner leur ci#50 v

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45

Mentz, Wayne. "Novel sulfanyl- and sulfinylcaffeine analogues as inhibitors of monoamine oxidase / Wayne Mentz." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9521.

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Parkinson’s disease (PD) is a neurodegenerative disorder, which is progressive in nature and usually associated with the elderly. It is the second most common age-related neurodegenerative disorder after Alzheimer’s disease (AD). PD occurs when there is a dramatic loss of dopamine (DA) in the striatum, a substructure of the basal ganglia, of the brain due to the degeneration of the nigrostriatal pathway that contains the dopaminergic neurons. Motor symptoms of PD include bradykinesia, muscular rigidity and resting tremors. Non-motor symptoms include speech and sleep problems, hallucinations an

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46

Chapdelaine, Alexandra. "Le Bisphénol A dans la prééclampsie." Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/9606.

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Résumé : La prééclampsie (PE) est un désordre de la grossesse caractérisée par une dysfonction endothéliale faisant en sorte que l’endothélium devient moins sensible aux signaux de vasodilatation. La réponse provoquée par la liaison de la sérotonine au sous-type de récepteur S[indice inférieur 2] entraîne la libération de molécules aux propriétés vasoconstrictrices, qui, par une boucle de rétroaction positive, entraîne la libération de davantage de sérotonine par les plaquettes. Cette boucle amplifie la réponse et contribue ainsi à l’hypertension présente chez les femmes ayant une PE. Précédem

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47

Doyle, Austin. "An investigation into the role and identity of tribulin." Thesis, University of Westminster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319684.

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48

PROUST, STEPHANE. "Le syndrome de kleine-levin : etude electroencephalographique de longue duree et exploration endocrinienne : a propos d'un cas." Toulouse 3, 1988. http://www.theses.fr/1988TOU31019.

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49

Jeanpetit, Christian. "Contribution à la synthèse de nouveaux inhibiteurs réversibles et sélectifs de la monoamine oxydase de type B." Paris 6, 1988. http://www.theses.fr/1988PA066311.

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50

Connil, Nathalie. "Étude physiologique et caractérisation génétique préliminaire de la production de tyramine par Carnobacterium divergens V41, souche au potentiel bioprotecteur dans le saumon fumé." Nantes, 2001. http://www.theses.fr/2001NANT2104.

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