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Journal articles on the topic 'Monoamine'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Zhou, Shi-Sheng, Yi-Ming Zhou, Da Li, and Qiang Ma. "Early Infant Exposure to Excess Multivitamin: A Risk Factor for Autism?" Autism Research and Treatment 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/963697.

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Autism, a neurodevelopmental disorder that affects boys more than girls, is often associated with altered levels of monoamines (serotonin and catecholamines), especially elevated serotonin levels. The monoamines act as both neurotransmitters and signaling molecules in the gastrointestinal and immune systems. The evidence related to monoamine metabolism may be summarized as follows: (i) monoamine neurotransmitters are enzymatically degraded/inactivated by three mechanisms: oxidative deamination, methylation, and sulfation. The latter two are limited by the supply of methyl groups and sulfate, r

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2

Aksoz, Begum E., and Erkan Aksoz. "Vital Role of Monoamine Oxidases and Cholinesterases in Central Nervous System Drug Research: A Sharp Dissection of the Pathophysiology." Combinatorial Chemistry & High Throughput Screening 23, no. 9 (2020): 877–86. http://dx.doi.org/10.2174/1386207323666200220115154.

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Background: Monoamine oxidase and cholinesterase enzymes are very critical enzymes that regulate the level of neurotransmitters such as acetylcholine and monoamines. Monoamine neurotransmitters and acetylcholine play a very important role in many physiological events. An increase or decrease in the amount of these neurotransmitters is observed in a wide range of central nervous system pathologies. Balancing the amount of these neurotransmitters is important in improving the progression of these diseases. Inhibitors of monoamine oxidase and cholinesterase enzymes are important in symptomatic th

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3

Anlauf, Martin, Rolf Eissele, Martin K. H. Schäfer, et al. "Expression of the Two Isoforms of the Vesicular Monoamine Transporter (VMAT1 and VMAT2) in the Endocrine Pancreas and Pancreatic Endocrine Tumors." Journal of Histochemistry & Cytochemistry 51, no. 8 (2003): 1027–40. http://dx.doi.org/10.1177/002215540305100806.

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The uptake of monoamines into the secretory granules of monoamine-storing neuroendocrine cells is mediated by vesicular monoamine transporter protein 1 or 2 (VMAT1 or VMAT2). This study analyzed the expression of VMAT1 and VMAT2 in endocrine cells of normal human and monkey pancreas. The expression of VMAT1 and VMAT2 was also examined in infants with hyperinsulinemic hypoglycemia and in adults with pancreatic endocrine tumors (PETs). Using immunohistochemistry (IHC) and in situ hybridization (ISH), we demonstrated the mutually exclusive expression of VMAT1 in endocrine cells of the duct system

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Murtazina, Alya R., Nadegda S. Bondarenko, Tatiana S. Pronina, et al. "A Comparative Analysis of CSF and the Blood Levels of Monoamines As Neurohormones in Rats during Ontogenesis." Acta Naturae 13, no. 4 (2021): 89–97. http://dx.doi.org/10.32607/actanaturae.11516.

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According to the literature, the cerebrospinal fluid (CSF) in the cerebral ventricles contains numerous neuron-derived physiologically active substances that can function as neurohormones and contribute to volume neurotransmission in the periventricular region of the brain. This study was aimed at carrying out a comparative analysis of CSF and the blood levels of monoamines in rats during ontogenesis as an indicator of age-related characteristics of monoamine transport to body fluids and their function as neurohormones in volume neurotransmission in the periventricular region of the brain. We

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Hollander, Eric. "Parkinson's Disease, Tourette Syndrome, and the Changing Nature of Depression: The Dog Days of Summer." CNS Spectrums 13, no. 8 (2008): 643–44. http://dx.doi.org/10.1017/s1092852900013729.

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Since the development of selective serotonin reuptake inhibitors there has been a widening of the definition of depression and a decrease in the placebo-drug difference in controlled studies. In the early 1960s, ~33% of depressed patients improved with placebo and 66% with active compounds and current controlled studies suggest that the situation has certainly not improved. The Sequenced Treatment Alternatives to Relieve Depression Study found that response rates to new compounds after the failure of the first antidepressant are low. The monoamine hypothesis of depression was formulated in the

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Belmaker, Robert H. "The Future of Depression Psychopharmacology." CNS Spectrums 13, no. 8 (2008): 682–87. http://dx.doi.org/10.1017/s1092852900013766.

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ABSTRACTAlong with the development of selective sertonin reuptake inhibitors there has been a tremendous widening of the definition of depression and an impressive decrease in the placebodrug difference in controlled studies. In the early 1960s, about one third of depressed patients improved with placebo and two thirds with active compounds. Current controlled studies suggest that the situation has certainly not improved. The Sequenced Treatment Alternatives to Relieve Depression Study found that response rates to new compounds after the failure of the first antidepressant are low. The monoami

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Mooslehner, Katrin A., Pok Man Chan, Weiming Xu, et al. "Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism." Molecular and Cellular Biology 21, no. 16 (2001): 5321–31. http://dx.doi.org/10.1128/mcb.21.16.5321-5331.2001.

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ABSTRACT We have created a transgenic mouse with a hypomorphic allele of the vesicular monoamine transporter 2 (Vmat2) gene by gene targeting. These mice (KA1) have profound changes in monoamine metabolism and function and survive into adulthood. Specifically, these animals express very low levels of VMAT2, an endogenous protein which sequesters monoamines intracellularly into vesicles, a process that, in addition to being important in normal transmission, may also act to keep intracellular levels of the monoamine neurotransmitters below potentially toxic thresholds. Homozygous mice show large

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8

Cai, Lu, Chao Wang, Xiao-kui Huo, et al. "Effect of Alkaloids Isolated fromPhyllodium pulchellumon Monoamine Levels and Monoamine Oxidase Activity in Rat Brain." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6826175.

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Phyllodium pulchellum(P. pulchellum) is a folk medicine with a significant number of bioactivities. The aim of this study was to investigate the effects displayed by alkaloids fractions, isolated from the roots ofP. pulchellum, on neurotransmitters monoamine levels and on monoamine oxidase (MAO) activity. Six alkaloids, which had indolealkylamine orβ-carboline skeleton, were obtained by chromatographic technologies and identified by spectroscopic methods such as NMR and MS. After treatment with alkaloids ofP. pulchellum, the reduction of DA levels (54.55%) and 5-HT levels (35.01%) in rat brain

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Nilsson, G. E., A. A. Alfaro, and P. L. Lutz. "Changes in turtle brain neurotransmitters and related substances during anoxia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 259, no. 2 (1990): R376—R384. http://dx.doi.org/10.1152/ajpregu.1990.259.2.r376.

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Freshwater turtles (Pseudemys scripta elegans) were exposed to 0.5-13 h of anoxia at 25 degrees C, whereupon the brain concentrations of 14 amino acid and monoamine neurotransmitters and related substances were measured. Monoamines are of particular interest, because their synthesis and (in part) degradation require molecular oxygen. During anoxia, the level of the inhibitory transmitter gamma-aminobutyric acid (GABA) increased (2.3-fold after 13 h) and the level of the excitatory transmitter Glu fell. Furthermore, anoxia caused increases in the levels of Ala (14 times after 13 h), Tau, Gly, a

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10

Nishimura, Mitsuhiro, Kohji Sato, Tomoya Okada, et al. "Ketamine Inhibits Monoamine Transporters Expressed in Human Embryonic Kidney 293 Cells." Anesthesiology 88, no. 3 (1998): 768–74. http://dx.doi.org/10.1097/00000542-199803000-00029.

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Background Ketamine has been characterized as having psychotomimetic and sympathomimetic effects. These symptoms have raised the possibility that ketamine affects monoaminergic neurotransmission. To elucidate the relation between ketamine and monoamine transporters, the authors constructed three cell lines that stably express the norepinephrine, dopamine, and serotonin transporters and investigated the effects of ketamine on these transporters. Methods Human embryonic kidney cells were transfected using the Chen-Okayama method with the human norepinephrine, rat dopamine, and rat serotonin tran

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Sepp, Krisztián, Zsolt Molnár, Anna M. László, et al. "Study of the Potential Endocrine-Disrupting Effects of Phenylurea Compounds on Neurohypophysis Cells In Vitro." International Journal of Endocrinology 2019 (February 10, 2019): 1–9. http://dx.doi.org/10.1155/2019/1546131.

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Homeostatic disruptor agents, and endocrine disruptor compounds (EDC) specifically, can originate from agricultural and industrial chemicals. If they modify the adaptation of living organisms as direct (e.g., by altering hormone regulation, membrane functions) and/or indirect (e.g., cell transformation mechanisms) factors, they are classified as EDC. We aimed to examine the potential endocrine-disrupting effects of phenylurea herbicides (phenuron, monuron, and diuron) on the oxytocin (OT) and arginine-vasopressin (AVP) release of neurohypophysis cell cultures (NH). In our experiments, monoamin

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Harvey, P. J., X. Li, Y. Li, and D. J. Bennett. "Endogenous Monoamine Receptor Activation Is Essential for Enabling Persistent Sodium Currents and Repetitive Firing in Rat Spinal Motoneurons." Journal of Neurophysiology 96, no. 3 (2006): 1171–86. http://dx.doi.org/10.1152/jn.00341.2006.

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The spinal cord and spinal motoneurons are densely innervated by terminals of serotonin (5-HT) and norepinephrine (NE) neurons arising mostly from the brain stem, but also from intrinsic spinal neurons. Even after long-term spinal transection (chronic spinal), significant amounts (10%) of 5-HT and NE (monoamines) remain caudal to the injury. To determine the role of such endogenous monoamines, we blocked their action with monoamine receptor antagonists and measured changes in the sodium currents and firing in motoneurons. We focused on persistent sodium currents (Na PIC) and sodium spike prope

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Bradner, Joshua M., Vrinda Kalia, Fion K. Lau, et al. "Genetic or Toxicant-Induced Disruption of Vesicular Monoamine Storage and Global Metabolic Profiling in Caenorhabditis elegans." Toxicological Sciences 180, no. 2 (2021): 313–24. http://dx.doi.org/10.1093/toxsci/kfab011.

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Abstract The proper storage and release of monoamines contributes to a wide range of neuronal activity. Here, we examine the effects of altered vesicular monoamine transport in the nematode Caenorhabditis elegans. The gene cat-1 is responsible for the encoding of the vesicular monoamine transporter (VMAT) in C. elegans and is analogous to the mammalian vesicular monoamine transporter 2 (VMAT2). Our laboratory has previously shown that reduced VMAT2 activity confers vulnerability on catecholamine neurons in mice. The purpose of this article was to determine whether this function is conserved an

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Martin-Iverson, Mathew T., and Bruce A. Lodge. "Effects of chronic treatment of rats with "designer" amphetamines on brain regional monoamines." Canadian Journal of Physiology and Pharmacology 69, no. 12 (1991): 1825–32. http://dx.doi.org/10.1139/y91-270.

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(+)-Amphetamine and two structurally related analogues, 4-methoxyamphetamine and a recent "designer drug," 4-ethoxy-amphetamine, were given to rats via subcutaneous osmotic minipumps for 1–14 days. Regional brain levels of the drugs as well as monoamine neurotransmitters and some of their major acidic metabolites were determined. Amphetamine produced depletions of dopamine in the striatum after at least 3 days of treatment but not in the nucleus accumbens or olfactory tubercle, even after 14 days of treatment. In contrast, the two ring-substituted amphetamine analogues increased levels of the

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Wallin, Anders, Kaj Blennow, Åke Edman, and Jan-Erik Månsson. "Decreased Lumbar Cerebrospinal Fluid Levels of Monoamine Metabolites in Vascular Dementia." International Psychogeriatrics 8, no. 3 (1996): 425–36. http://dx.doi.org/10.1017/s1041610296002785.

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The levels of the monoamine metabolites 5-hydroxy-indoleacetic acid (5-HIAA), homovanillic acid (HVA), and 4-hydroxy-3-methoxyphenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 56 patients with vascular dementia (VAD) and 57 healthy controls. Despite CSF sampling under standardized conditions, the variability in values was wide among both patients and controls. This suggests that yet unknown factors affect the lumbar CSF concentrations of monoamine metabolites. The VAD group showed significantly lower mean concentrations of 5-HIAA (p < .001) and HVA (p < .001) tha

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D'Amico, Jessica M., Katherine C. Murray, Yaqing Li та ін. "Constitutively active 5-HT2/α1 receptors facilitate muscle spasms after human spinal cord injury". Journal of Neurophysiology 109, № 6 (2013): 1473–84. http://dx.doi.org/10.1152/jn.00821.2012.

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In animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-HT2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents (CaPICs) without the ligands serotonin and norepinephrine below the injury. In this study we sought evidence for a similar role of constitutive monoamine receptor activity in the development of spasticity in human spinal cord injury. In chronically injured participants with partially preserved senso

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Krysenko, Sergii, and Wolfgang Wohlleben. "Polyamine and Ethanolamine Metabolism in Bacteria as an Important Component of Nitrogen Assimilation for Survival and Pathogenicity." Medical Sciences 10, no. 3 (2022): 40. http://dx.doi.org/10.3390/medsci10030040.

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Nitrogen is an essential element required for bacterial growth. It serves as a building block for the biosynthesis of macromolecules and provides precursors for secondary metabolites. Bacteria have developed the ability to use various nitrogen sources and possess two enzyme systems for nitrogen assimilation involving glutamine synthetase/glutamate synthase and glutamate dehydrogenase. Microorganisms living in habitats with changeable availability of nutrients have developed strategies to survive under nitrogen limitation. One adaptation is the ability to acquire nitrogen from alternative sourc

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Boyle, Natalie, Sarah Betts, and Hui Lu. "Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex." Brain Sciences 14, no. 9 (2024): 902. http://dx.doi.org/10.3390/brainsci14090902.

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Extensive research has shed light on the cellular and functional underpinnings of higher cognition as influenced by the prefrontal cortex. Neurotransmitters act as key regulatory molecules within the PFC to assist with synchronizing cognitive state and arousal levels. The monoamine family of neurotransmitters, including dopamine, serotonin, and norepinephrine, play multifaceted roles in the cognitive processes behind learning and memory. The present review explores the organization and signaling patterns of monoamines within the PFC, as well as elucidates the numerous roles played by monoamine

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Huang, Yu-Hong, Akio Ito, and Ryohachi Arai. "Immunohistochemical Localization of Monoamine Oxidase Type B in Pancreatic Islets of the Rat." Journal of Histochemistry & Cytochemistry 53, no. 9 (2005): 1149–58. http://dx.doi.org/10.1369/jhc.5a6658.2005.

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Monoamine oxidase (MAO) is regarded as a mitochondrial enzyme. This enzyme localizes on the outer membrane of mitochondria. There are two kinds of MAO isozymes, MAO type A (MAOA) and type B (MAOB). Previous studies have shown that MAOB activity is found in the pancreatic islets. This activity in the islets is increased by the fasting-induced decrease of plasma glucose level. Islet B cells contain monoamines in their secretory granules. These monoamines inhibit the secretion of insulin from the B cells. MAOB is active in degrading monoamines. Therefore, MAOB may influence the insulin-secretory

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Inyushin, M. Y., A. Huertas, Y. V. Kucheryavykh, et al. "L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain." Parkinson's Disease 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/321406.

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Astrocyte endfeet surround brain blood vessels and can play a role in the delivery of therapeutic drugs for Parkinson’s disease. However, there is no previous evidence of the presence of LAT transporter forL-DOPA in brain astrocytes except in culture. Using systemicL-DOPA administration and a combination of patch clamp, histochemistry and confocal microscopy we found thatL-DOPA is accumulated mainly in astrocyte cell bodies, astrocytic endfeet surrounding blood vessels, and pericytes. In brain slices: (1) astrocytes were exposed to ASP+, a fluorescent monoamine analog of MPP+; (2) ASP+taken up

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Kozlovskii, V. L., M. Yu Popov, D. N. Kosterin, and O. V. Lepik. "Heterogeneity of the mechanisms of action of antidepressants." V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, no. 1 (April 12, 2021): 11–17. http://dx.doi.org/10.31363/2313-7053-2021-1-11-17.

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The article discusses the heterogeneous mechanisms of the pharmacodynamics of antidepressants that underlie the therapeutic response. Sharing the similar clinical activity, antidepressants determine the development of drug-induced homeostasis by means of different molecular mechanisms (selective or nonselective blockade of monoamine reuptake, inhibition of monoamine oxidase, blockade of certain monoamine receptors). However, an increase of serotonin and other monoamines concentrations in the synapses of the central nervous system is only the initiating factor in the development of specific cli

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Ernst, M. "Selegiline in ADHD Adults: Plasma Monoamines and Monoamine Metabolites." Neuropsychopharmacology 16, no. 4 (1997): 276–84. http://dx.doi.org/10.1016/s0893-133x(96)00243-6.

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Favoretto, Cristiane A., Yasmin C. Nunes, Giovana C. Macedo, Janaína Silva Rocha Lopes, and Isabel M. Hartmann Quadros. "Chronic social defeat stress: Impacts on ethanol-induced stimulation, corticosterone response, and brain monoamine levels." Journal of Psychopharmacology 34, no. 4 (2020): 412–19. http://dx.doi.org/10.1177/0269881119900983.

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Background: Chronic exposure to stress may dysregulate the hypothalamic-pituitary-adrenal axis and brain monoamine levels, contributing to the development of ethanol dependence. Exposure to chronic social defeat stress may impact ethanol-related effects, neural, and endocrine functions. Aim: This study assessed ethanol-induced locomotor activity, corticosterone responses, and brain monoamine levels in Swiss albino mice 10 days post-exposure to chronic social defeat stress. Methods: During a period of 10 days, male Swiss mice were exposed to daily defeat episodes, followed by housing with an ag

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Andriuskevicius, Tomas, Brenna Parke, Anna Rhodes, Leigh Knight, Parastoo Hashemi, and Claire A. Higgins. "P20 Characterizing monoamine signalling in human dermal fibroblasts and keratinocytes." British Journal of Dermatology 190, no. 6 (2024): e88-e88. http://dx.doi.org/10.1093/bjd/ljae105.042.

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Abstract Introduction and aims Our mental health depends upon a fine balance of monoamines in the brain. Interestingly, there is ample evidence indicating that mental health disorders such as stress or anxiety have an impact on skin condition and appearance. For example, stress induces neurogenic inflammation, which in turn leads to mast cell degranulation in the skin and increases local histamine levels. This increased histamine within the skin exacerbates skin conditions such as eczema and psoriasis, while impacting the skin barrier. In this study, we first sought to investigate monoamine si

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Quarta, Davide, and Charles H. Large. "Effects of lamotrigine on PCP-evoked elevations in monoamine levels in the medial prefrontal cortex of freely moving rats." Journal of Psychopharmacology 25, no. 12 (2010): 1703–11. http://dx.doi.org/10.1177/0269881110385598.

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Lamotrigine is suggested to have potential as an add-on treatment for patients with schizophrenia. Supporting evidence comes from the efficacy of the drug in models of psychotic-like behaviour induced by N-methyl-D-aspartate (NMDA) receptor antagonists, such as phencyclidine (PCP). These drugs enhance levels of the monoamines in the cortex, which may contribute to their psychotomimetic effects. The ability of lamotrigine to prevent these neurochemical changes has not been examined. We studied PCP-evoked overflow of noradrenaline, dopamine and serotonin in the medial prefrontal cortex of awake

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Noga, Brian R., Alberto Pinzon, Riza P. Mesigil, and Ian D. Hentall. "Steady-State Levels of Monoamines in the Rat Lumbar Spinal Cord: Spatial Mapping and the Effect of Acute Spinal Cord Injury." Journal of Neurophysiology 92, no. 1 (2004): 567–77. http://dx.doi.org/10.1152/jn.01035.2003.

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Monoamines in the spinal cord are important in the regulation of locomotor rhythms, nociception, and motor reflexes. To gain further insight into the control of these functions, the steady-state extracellular distribution of monoamines was mapped in the anesthetized rat's lumbar spinal cord. The effect of acute spinal cord lesions at sites selected for high resting levels was determined over ∼1 h to estimate contributions to resting levels from tonic descending activity and to delineate chemical changes that may influence the degree of pathology and recovery after spinal injury. Measurements e

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Popov, N. S., D. A. Gavrilenko, V. Yu Balabanyan, et al. "Quantitative determination of monoamine neurotransmitters in rat brain homogenates using HPLC-MS/MS." Pharmacokinetics and Pharmacodynamics, no. 4 (January 18, 2023): 33–42. http://dx.doi.org/10.37489/2587-7836-2022-4-33-42.

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Relevance. Evaluation of the effect of drugs on neurotransmitter processes is an important component of pharmacodynamic studies. The quantitative determination of monoamine neurotransmitters in the brain structures of laboratory animals is an urgent task of pharmacology and physiology.Purpose of the study. Development of a method for the quantitative determination of serotonin, dopamine, norepinephrine, histamine and epinephrine in rat brain homogenates using HPLC-MS/MS.Methods. The isolation of neurotransmitters from the brain of rats was carried out by homogenizing the biomaterial with aceto

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Ramesh, Muthusamy, and Arunachalam Muthuraman. "Quantitative Structure-Activity Relationship (QSAR) Studies for the Inhibition of MAOs." Combinatorial Chemistry & High Throughput Screening 23, no. 9 (2020): 887–97. http://dx.doi.org/10.2174/1386207323666200324173231.

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Monoamine oxidases are the crucial drug targets for the treatment of neurodegenerative disorders like depression, Parkinson’s disease, and Alzheimer’s disease. The enzymes catalyze the oxidative deamination of several monoamine containing neurotransmitters, i.e. serotonin (5-HT), melatonin, epinephrine, norepinephrine, phenylethylamine, benzylamine, dopamine, tyramine, etc. The oxidative reaction of monoamine oxidases results in the production of hydrogen peroxide that leads to the neurodegeneration process. Therefore, the inhibition of monoamine oxidases has shown a profound effect against ne

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Petkov, V. D., S. L. Stancheva, V. V. Petkov, and L. G. Alova. "Age-related changes in brain biogenic monoamines and monoamine oxidase." General Pharmacology: The Vascular System 18, no. 4 (1987): 397–401. http://dx.doi.org/10.1016/0306-3623(87)90097-8.

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Hamalainen, M., and J. Kohonen. "Studies on the effect of monoamine antagonists on the morphogenesis of the newt." International Journal of Developmental Biology 33, no. 1 (1989): 157–63. https://doi.org/10.1387/ijdb.2562047.

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The effects of three monoamine antagonists, p-chlorophenylalanine, diethyldithiocarbamate and propranolol on the morphogenesis of newt embryos were studied. Antagonists were administered during late blastula through neurula stages. In a concentration of 1 mM, all three arrested gastrulation and caused disintegration of the embryos. Lower concentrations (0.1-0.5 mM) retarded morphogenetic movements in the gastrulation and caused malformations especially in the anterior parts of the embryos; pigmentation was delayed by 1 or 2 days. In addition, p-CIPhe inhibited yolk granule degradation in the n

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Raffo, Anthony, Kolbe Hancock, Teresa Polito, et al. "Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine." Journal of Endocrinology 198, no. 1 (2008): 41–49. http://dx.doi.org/10.1677/joe-07-0632.

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AbstractDespite different embryological origins, islet β-cells and neurons share the expression of many genes and display multiple functional similarities. One shared gene product, vesicular monoamine transporter type 2 (VMAT2, also known as SLC18A2), is highly expressed in human β-cells relative to other cells in the endocrine and exocrine pancreas. Recent reports suggest that the monoamine dopamine is an important paracrine and/or autocrine regulator of insulin release by β-cells. Given the important role of VMAT2 in the economy of monoamines such as dopamine, we investigated the possible ro

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Williams, C. H., J. Lawson, and F. R. C. Backwell. "Oxidation of 3-amino-1-phenylprop-1-enes by monoamine oxidase and their use in a continuous assay of the enzyme." Biochemical Journal 256, no. 3 (1988): 911–15. http://dx.doi.org/10.1042/bj2560911.

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3-Amino-1-phenylprop-1-ene (cinnamylamine) and some derivatives were examined as substrates for monoamine oxidases A and B in mitochondria. All of the amines examined were readily oxidized by monoamine oxidase B but much less readily by monoamine oxidase A. E-Cinnamylamine was found to have Km 0.025 mM and Vmax. 3.9 nmol/min per mg of mitochondrial protein. Corresponding values with monoamine oxidase A were 0.026 mM and 0.85 nmol/min per mg respectively. Despite their different stereochemistry, E- and Z-N-methylcinnamylamines were almost equally effective as substrates for monoamine oxidase B.

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Taraskina, A. E., A. M. Zabotina, R. F. Nasyrova, et al. "The effect of antipsychotic drug on monoamine receptors in peripheral blood mononuclear cells: affinity linked mechanism." Biomeditsinskaya Khimiya 64, no. 2 (2018): 201–7. http://dx.doi.org/10.18097/pbmc20186402201.

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Schizophrenia is one of the most serious and common mental disorders, which is characterized by high levels of pathogenic heterogeneity as well as neuroimmune abnormalities, which require treatment with antipsychotic drugs. Monoamines are one of the key neurotransmitters which play an important role in neuroimmune interactions of the human organism. We suggest that the quantity of the monoamine receptors on mononuclear cells of the peripheral blood (PBMCs) can be associated with the cytokine profile of patients. With this quantity being a key component of the mental status correction mechanism

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Stahl, Stephen M. "Dextromethorphan/Bupropion: A Novel Oral NMDA (N-methyl-d-aspartate) Receptor Antagonist with Multimodal Activity." CNS Spectrums 24, no. 5 (2019): 461–66. http://dx.doi.org/10.1017/s1092852919001470.

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Although currently available antidepressants increase monoamine levels soon after the start of treatment, therapeutic benefits are often delayed by several weeks and the majority of patients with major depressive disorder fail to achieve an adequate response to first- or second-line therapies targeting monoamines. The recent approval of the NMDA (N-methyl-d-aspartate) antagonist esketamine given intranasally for treatment-resistant depression has reinforced the need for agents with rapid onset with alternate mechanisms of action. Dextromethorphan/bupropion, an investigational medicine currentl

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Lin, Yuh-Tzy, Wei-Shih Huang, Huei-Yann Tsai, Min-Min Lee, and Yuh-Fung Chen. "In vivo microdialysis and in vitro HPLC analysis of the impact of paeoniflorin on the monoamine levels and their metabolites in the rodent brain." BioMedicine 9, no. 2 (2019): 11. http://dx.doi.org/10.1051/bmdcn/2019090211.

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Background: Paeoniflorin (PF) possesses several effects such as analgesic, the anti-spasmodic effect on smooth muscle. It protects the cardiovascular system and reveals the neuroprotective effect on cerebral ischemia. Monoamine system has been identified to have complex regulatory effects in pain signaling. There are no reports regarding the impact of PF on monoamine levels in the rodent brain by microdialysis. In this study, the effects of PF on monoamines and their metabolites in the rodent brain using in vivo microdialysis and in vitro high performance liquid chromatography (HPLC) analysis.

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MAYES, LINDA C. "Developing brain and in utero cocaine exposure: Effects on neural ontogeny." Development and Psychopathology 11, no. 4 (1999): 685–714. http://dx.doi.org/10.1017/s0954579499002278.

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Within the last decade, many investigators have focused on the physical, neurodevelopmental, and neuropsychological effects of prenatal cocaine exposure on infants and young children. Although inconclusive on many crucial issues, published studies reveal the beginnings of a profile of possible cocaine-related effects on neuropsychological functions subserving arousal and attention regulation. That profile is informed by preclinical studies in which important factors such as duration and type of exposure as well as environmental conditions may be more adequately controlled. In the developing br

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Schreiber, MD, JA Madden, RF Covert, MB Hershenson, and LJ Torgerson. "Concentration-dependent effects of cocaine on monoamine-induced constriction of cannulated, pressurized cerebral arteries from fetal sheep." Reproduction, Fertility and Development 7, no. 5 (1995): 1389. http://dx.doi.org/10.1071/rd9951389.

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Drugs, such as cocaine, which may alter monoamine neurotransmitter responsiveness, could adversely affect the regulation of cerebral vasculature. Cocaine exhibits at least two mechanisms that may alter vascular responsiveness: synaptic uptake inhibition, which may augment response to stimulation, and Na+ channel inhibition, which may attenuate response. To help elicit the concentration-dependent effects of cocaine, the effects of cocaine on monoamine neurotransmitter responsiveness were studied in vitro on fetal sheep cerebral arteries (120 days gestation). The changes in diameter of segments

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Goldberg, Joel S., Clifton E. Bell, and David A. Pollard. "Revisiting the Monoamine Hypothesis of Depression: A New Perspective." Perspectives in Medicinal Chemistry 6 (January 2014): PMC.S11375. http://dx.doi.org/10.4137/pmc.s11375.

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As the incidence of depression increases, depression continues to inflict additional suffering to individuals and societies and better therapies are needed. Based on magnetic resonance spectroscopy and laboratory findings, gamma aminobutyric acid (GABA) may be intimately involved in the pathophysiology of depression. The isoelectric point of GABA (pI = 7.3) closely approximates the pH of cerebral spinal fluid (CSF). This may not be a trivial observation as it may explain preliminary spectrophotometric, enzymatic, and HPLC data that monoamine oxidase (MAO) deaminates GABA. Although MAO is known

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Beaver, Jasmin N., Brady L. Weber, Matthew T. Ford, Anna E. Anello, Sarah K. Kassis, and T. Lee Gilman. "Uncovering Functional Contributions of PMAT (Slc29a4) to Monoamine Clearance Using Pharmacobehavioral Tools." Cells 11, no. 12 (2022): 1874. http://dx.doi.org/10.3390/cells11121874.

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Plasma membrane monoamine transporter (PMAT, Slc29a4) transports monoamine neurotransmitters, including dopamine and serotonin, faster than more studied monoamine transporters, e.g., dopamine transporter (DAT), or serotonin transporter (SERT), but with ~400–600-fold less affinity. A considerable challenge in understanding PMAT’s monoamine clearance contributions is that no current drugs selectively inhibit PMAT. To advance knowledge about PMAT’s monoamine uptake role, and to circumvent this present challenge, we investigated how drugs that selectively block DAT/SERT influence behavioral readou

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Benedetti, M. Strolin, P. Dosiert, and K. F. Tipton. "Developmental Aspects of the Monoamine-Degrading Enzyme Monoamine Oxidase." Developmental Pharmacology and Therapeutics 18, no. 3-4 (1992): 191–200. http://dx.doi.org/10.1159/000480622.

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Fišar, Zdeněk. "Cannabinoids and monoamine neurotransmission with focus on monoamine oxidase." Progress in Neuro-Psychopharmacology and Biological Psychiatry 38, no. 1 (2012): 68–77. http://dx.doi.org/10.1016/j.pnpbp.2011.12.010.

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Stancheva, S. L., and L. G. Alova. "Adafenoxate: A monoamine oxidase and biogenic monoamine uptake inhibitor." Pharmacological Research 31 (January 1995): 128. http://dx.doi.org/10.1016/1043-6618(95)86771-6.

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Roy, Alec, David Pickar, Markku Linnoila, Allen R. Doran, Philip Ninan, and Steven M. Paul. "Cerebrospinal fluid monoamine and monoamine metabolite concentrations in melancholia." Psychiatry Research 15, no. 4 (1985): 281–92. http://dx.doi.org/10.1016/0165-1781(85)90065-4.

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Heninger, G., P. Delgado, and D. Charney. "The Revised Monoamine Theory of Depression: A Modulatory Role for Monoamines, Based on New Findings From Monoamine Depletion Experiments in Humans." Pharmacopsychiatry 29, no. 01 (1996): 2–11. http://dx.doi.org/10.1055/s-2007-979535.

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Sacher, Julia, Eugenii A. Rabiner, Michael Clark, et al. "Dynamic, Adaptive Changes in MAO-A Binding after Alterations in Substrate Availability: An in vivo [11C]-Harmine Positron Emission Tomography Study." Journal of Cerebral Blood Flow & Metabolism 32, no. 3 (2011): 443–46. http://dx.doi.org/10.1038/jcbfm.2011.184.

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Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex ( P<0.031), and elevated (mean: 17%±11%) in striatum following carbidopa—levodopa administra

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Abidi, S. M. A., and W. A. Nizami. "Monoamine oxidase in amphistomes and its role in worm motility." Journal of Helminthology 74, no. 4 (2000): 283–88. http://dx.doi.org/10.1017/s0022149x0000041x.

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AbstractThe quantitative assay of mitochondrial monoamine oxidase (MAO) activity revealed a higher enzyme level in Explanatum explanatum than Gastrothylax crumenifer. The specific MAO inhibitors, chlorgyline, pargyline, deprenyl and nialamide produced different degrees of interspecific inhibition. The differential effects on enzyme activity of chlorgyline and deprenyl suggests the possible existence of polymorphic forms of the enzyme, MAO-A and MAO-B, in amphistomes. These specific inhibitors also had a differential influence on the in vitro motility of amphistomes, further indicating the invo

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Abidi, S. M. A., and W. A. Nizami. "Monoamine oxidase in amphistomes and its role in worm motility." Journal of Helminthology 74, no. 4 (2000): 283–88. http://dx.doi.org/10.1017/s0022149x00701039.

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AbstractThe quantitative assay of mitochondrial monoamine oxidase (MAO) activity revealed a higher enzyme level in Explanatum explanatum than Gastrothylax crumenifer. The specific MAO inhibitors, chlorgyline, pargyline, deprenyl and nialamide produced different degrees of interspecific inhibition. The differential effects on enzyme activity of chlorgyline and deprenyl suggests the possible existence of polymorphic forms of the enzyme, MAO-A and MAO-B, in amphistomes. These specific inhibitors also had a differential influence on the in vitro motility of amphistomes, further indicating the invo

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Qiu, Jingying, Chengjiang Li, Zhichun Dong, and Jing Wang. "Anti-diabetic effect of a monoamine oxidase inhibitor (tranylcypromine) in rats with poorly-controlled blood glucose levels: A potential and novel therapeutic option for diabetes." Tropical Journal of Pharmaceutical Research 19, no. 6 (2020): 1249–54. http://dx.doi.org/10.4314/tjpr.v19i6.20.

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Purpose: To determine the anti-diabetic effect of a monoamine oxidase inhibitor (tranylcypromine) in sulphonyl urea-refractory rats with poorly-controlled blood glucose levels.Methods: Alloxan-induced diabetic Wistar rats were assigned to two groups (30 rats/group). One group received glibenclamide at a dose of 0.6 mg/kg, while the other group was given monoamine oxidase inhibitor (tranylcypromine) at a dose of 5 mg/day. The two groups were treated for 2 weeks. Blood samples were collected at baseline (before treatment) and at the end of treatment for determination of plasma glucose (fasting a

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Delogu, G. L., F. Pintus, L. Mayán, et al. "MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, in vitro study, and docking calculations." MedChemComm 8, no. 9 (2017): 1788–96. http://dx.doi.org/10.1039/c7md00311k.

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Jiang, Yao, Di Zou, Yumeng Li, et al. "Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders." Pharmaceuticals 15, no. 10 (2022): 1203. http://dx.doi.org/10.3390/ph15101203.

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Major depressive disorder (MDD) is a common and complex mental disorder, that adversely impacts an individual’s quality of life, but its diagnosis and treatment are not accurately executed and a symptom-based approach is utilized in most cases, due to the lack of precise knowledge regarding the pathophysiology. So far, the first-line treatments are still based on monoamine neurotransmitters. Even though there is a lot of progress in this field, the mechanisms seem to get more and more confusing, and the treatment is also getting more and more controversial. In this study, we try to review the

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