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Dissertations / Theses on the topic 'Monoamino oxidase'

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Published: 4 June 2021
Last updated: 18 February 2022

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1

Figueira, Fernanda Hernandes. "EFEITO DO DISSELENETO DE DIFENILA SOBRE ALTERAÇÕES COMPORTAMENTAIS E BIOQUÍMICAS INDUZIDAS POR ANFETAMINA EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/11225.

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Selenium is an element that can modulate the dopaminergic neurotransmission. Studies show that diphenyl diselenide, an organic compound of selenium, has antioxidant activity improves depressive-like behavior and reduce the activity of the enzyme monoamine oxidase (MAO). However, there are few studies concerning about possible alterations of diphenyl diselenide in dopaminergic system. Thus, the purpose of the present study was to evaluate the effects of acute and sub-chronic treatment of diphenyl diselenide on amphetamine-induced behavioral and biochemical alterations in mice. In the acute trea
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Modena, Camila Sanches Cibantos Amaral de. "Influências de um inibidor seletivo da monoamino-oxidase tipo-B (IMAO-B) na sensibilização comportamental para anfetamina em camundongos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/47/47135/tde-17102006-112610/.

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A sensibilização comportamental é caracterizada por aumento no efeito comportamental de uma droga após administrações repetidas. Este fenômeno é intensamente aplicado em estudos com modelos animais que enfocam a dependência de drogas. A maioria destas drogas promove adaptações em sistemas de neurotransmissão, (ex. sistema dopaminérgico), como é o caso da anfetamina, morfina e etanol. No entanto, estudos que avaliam os efeitos de drogas administradas durante a abstinência e posterior expressão de sensibilização comportamental são escassos. Neste trabalho avaliou-se as influências de um inibidor
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Pesarico, Ana Paula. "ENVOLVIMENTO DOS SISTEMAS SEROTONINÉRGICO E DOPAMINÉRGICO NA AÇÃO DO TIPO ANTIDEPRESSIVA DO 7-FLÚOR-1,3 DIFENILISOQUINOLINA-1-AMINO EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/11237.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Depression is a psychiatric disorder associated with a negative impact on quality of life. Monoaminergic system has been involved in this disease and in the action of antidepressants. This study aimed to investigate the potential antidepressant-like of 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) and the possible involvement of monoaminergic system. Results showed that FDPI (1, 10 and 20 mg/kg, intragastric (i.g.)) reduced the immobility time, increased swimming time, but did not alter climbing time of mice in the modified forc
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4

Quines, Caroline Brandão. "ESTUDO DA TOXICOLOGIA E DA FARMACOLOGIA DO 2-FENILETINILBUTIL-TELÚRIO EM ROEDORES." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/11223.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The organotellurium compounds have been the subject of research due to their pharmacological and toxicological properties. It is believed that the main mechanism involved in the toxicity of these compounds is the ability to interact with sulfhydryl groups from molecules biologically active. Beyond the toxicological effects, some pharmacological properties have been attributed to organotellurium compounds. This study aimed to investigate the potential toxicological and pharmacologic of 2-phenylethynyl-butyltellurium (PEBT) through e
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5

Mullan, Elaine L. "Inhibitors of monoamine oxidase." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337116.

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6

Kaushal, Setu. "Characterization of Three Putative Monoamine Oxidase Genes in Caenorhabditis elegans." Ohio University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1218747926.

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7

Stenström, Anders. "Intra- and extraneuronal monoamine oxidase (MAO)." Umeå : [University of Umeå], 1986. http://catalog.hathitrust.org/api/volumes/oclc/15239401.html.

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8

Fitzgerald, Julia. "Monoamine oxidase in neuronal cell death." Thesis, Nottingham Trent University, 2008. http://irep.ntu.ac.uk/id/eprint/51/.

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Monoamine oxidase (MAO) is an oxidative enzyme that deaminates a variety of amine substrates, including the neurotransmitter dopamine. The enzymatic reaction requires molecular oxygen and produces hydrogen peroxide as a by-product. MAO is localised in the outer mitochondrial membrane and exists as two isoforms, MAO-A and MAO-B, which are differentially expressed in the body and differ in their substrate and inhibitor specificities. Previous studies have suggested that MAO-generated reactive oxygen species (ROS) contribute to oxidative stress in the cell and can directly inhibit electron transp
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9

Yeomanson, K. B. "An immunochemical analysis of monoamine oxidase profiles." Thesis, Nottingham Trent University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254741.

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10

Wu, Bo. "Structure-function relationships in monoamine oxidase B /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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11

Foka, Germaine Boulenoue. "Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease." University of the Western Cape, 2016. http://hdl.handle.net/11394/5549.

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Magister Pharmaceuticae - MPharm<br>Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language skills and other cognitive impairments to occur. The hallmarks of AD include the presence of extracellular insoluble amyloid beta plaques, intracellular neurofibrillary tangles, and the decrease in ACh concentration. The pathophysiology of AD is not well understood, however, acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and mon
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12

Backwell, Colette. "Labels for the active site of monoamine oxidase." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336043.

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13

Vince, Matthew Joseph Kline. "Examining Monoamine Oxidase Inhibitor Targets Using Caenorhabditis elegans." Ohio University Art and Sciences Honors Theses / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1598384776888279.

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14

Booysen, Hermanus Perold. "Thiocaffeine derivatives as inhibitors of monoamine oxidase / Booysen H.P." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7348.

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Parkinson’s disease (PD) is a neurodegenerative disorder which is characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) of the brain and reduced striatal dopamine (DA). Neuropathologically, PD is characterized by the presence of intraneuronal inclusions called Lewy Bodies (LBs). While the pathogenesis of PD is unknown, it is thought that monoamine oxidase (MAO) may play an important role in the neurodegenerative process. In the basal ganglia DA is oxidized by MAO, a process which is associated with the formation of toxic metabolic by–products. For
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15

Odhar, Hasanain. "Identification of novel scaffolds for Monoamine oxidase B inhibitors." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1394416913.

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16

Parboosingh, Jillian S. "Biochemical and molecular analysis of monoamine oxidase in alcoholics, high risk subjects and low risk controls." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61088.

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Alcoholism is a prevalent multifactorial disease with both genetic and environmental components. Monoamine oxidase (MAO) has been proposed as a susceptibility marker for familial alcoholism but consistent evidence of either specific MAO variants in alcoholics or allelic segregation in at-risk families has not been presented. Two structural genes on the X chromosome encode two forms of the enzyme, MAO-A and MAO-B. Kinetic constants for platelet MAO-B and restriction fragment length polymorphisms for MAO-A were determined in alcoholics with multigenerational family histories of alcoholism, high
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17

Escrig, Ayuso Miguel Ángel. "Implicación de la monoamino oxidasa en conductas inducidas por etanol." Doctoral thesis, Universitat Jaume I, 2016. http://hdl.handle.net/10803/669006.

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La catalasa utiliza como cosubstrato el peróxido de hidrógeno (H2O2) para formar el compuesto I (catalasa- H2O2) que es el principal sistema de metabolismo de etanol (EtOH) en el sistema nervioso central (SNC). De este modo, el etanol se metaboliza a acetaldehído por la actividad del compuesto I. Se ha demostrado que las manipulaciones farmacológicas que varían los niveles de catalasa central producen una modificación de los efectos que el EtOH produce en roedores. También se han observado resultados similares cuando se han comparado estirpes de ratones con diferentes niveles de catalasa cen
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18

Sørensen, Izel Fourie. "Influence of tobacco smoke constituents on monoamine oxidase activity in vitro and on human placental monoamine oxidase A activity in vivo / Izel Fourie Sørensen." Thesis, North-West University, 2004. http://hdl.handle.net/10394/294.

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The aim of this study was to investigate the influence of tobacco smoke on monoamine oxidase activity, and of smoking during pregnancy on placental monoamine oxidase A (MAO-A) activity. The enzyme MA0 exists in two isoforms, MAO-A and MAO-B, both of which are important in regulating monoamine status in the brain and periphery. Some substrate selectivity for particular monoamines is a characteristic of these isoforms, and one form of the enzyme may predominate in particular organs. Recreational tobacco smoking influences the status of monoamine oxidases in the body. In vivo studies using PET im
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Finch, Cheryl Christine. "An immunochemical analysis of monoamine oxidase in health and disease." Thesis, Nottingham Trent University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298903.

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20

Gibb, Celia Margaret. "Environment and neurological illness : role of monoamine oxidase and phenolsulphotransferase." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47072.

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21

Wan, Li. "Monoamine Oxidase and Sensory Gating: Psychophysiological Vulnerabilities among Teenage Smokers." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/27380.

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Smoking is one of the leading causes of death in the world. About 80% of smokers start smoking before the age of 18. In the Appalachian area and the South in the United States, smoking percentages among adults and adolescents are higher than in other regions. Female smoking shows a variety of different trends from male smoking, and smoking brings particular health problems related to production to female smokers. These findings highlighted the importance of studying female teenage smokers in southwest Virginia. The initial project aimed to identify risk factors that might prevent smoking in an
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22

Gretton, Heather Margaret. "Platelet monoamine oxidase type B (MAO-B) activity in psychopathy." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30619.

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Studies of platelet MAO-B activity have revealed a link between low platelet activity and psychiatric syndromes characterized by an inability to control impulses and to anticipate future consequences of behavior (Oreland, 1980; Gottfries, von Knorring, & Oreland, 1980). These characteristics are fundamental to the construct of psychopathy, and we might therefore expect that psychopathy is associated with low MAO activity. Indeed, some investigators have suggested that low platelet MAO-B activity is a potential marker for vulnerability to psychopathy (Schalling, Asberg, Edman, & Oreland, 1987).
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Maurel, Agnès. "Monoamine oxydases rénales et cardiaques : implications physiopathologiques." Paris 7, 2004. http://www.theses.fr/2004PA077127.

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24

Isin, Emre M. "Potential Prodrugs of the Neuronal Nitric Oxide Synthase and Monoamine Oxidase Inhibitor 7-Nitroindazole and Structurally Related Compounds." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/35829.

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Parkinson's disease (PD) is a progressive neurodegenerative disorder of unknown cause that afflicts about 1.5 million Americans. The characteristic feature of PD is a deficiency of dopamine in the terminals of nigrostriatal neurons. Two enzyme systems, the neuronal form of nitric oxide synthase (nNOS) and monoamine oxidase B (MAO-B), have been linked to neurodegenerative pathways leading to PD. Several MAO-B and nNOS inhibitors have been evaluated for their neuroprotective properties in the mouse model of neurodegeneration which employs the parkinsonian inducing neurotoxin 1-methyl-4-phenyl-1,
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25

Doyle, Austin. "An investigation into the role and identity of tribulin." Thesis, University of Westminster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319684.

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26

Sivasubramaniam, S. D. "Monoamine oxidase expression in non-CNS tissues and pregnancy-induced hypertension." Thesis, Nottingham Trent University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271798.

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Monoamine oxidase (MAO) is an outer mitochondrial membrane bound enzyme responsible for the oxidative deamination of a wide variety of biogenic and xenobiotic amines. Altered MAO activity has been reported in a number of medical and psychiatric disorders. Although the tissue distribution of these enzymes has been extensively studied, the localization of MAO proteins and mRNAs at the cellular level in peripheral tissues, including placenta, has not been fully established. In addition the status of placental MAO in pre-eclampsia - a severe disorder of pregnancy has not been fully studied, despit
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Repsold, Benjamin Petrus. "Inhibition of monoamine oxidase B by substituted coumarin derivatives / Bennie Repsold." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4177.

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Interest in the selective inhibition of monoamine oxidase B (MAO-B) has increased in the last years due to their therapeutic potential in age related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Reversibly inhibiting MAO-B reduces the oxidative deamination of dopamine, increases dopamine levels and, consequently, reduces the production of reactive oxygen species (ROS) which may be the therapeutic intervention that positively affect the tempo and progression of neurodegenerative diseases. Coumarin analogues exhibit a broad spectrum of pharmacological activity,
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Strydom, Belinda. "Inhibition of monoamine oxidase by caffeine- and phthalide analogues / Belinda Strydom." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9535.

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Monoamine oxidase (MAO) consists of two isoforms, MAO-A and MAO-B. MAO is responsible for the oxidation of neurotransmitter and dietary amines. The MAO-B isoform, in particular, is considered to be a drug target for the treatment of neurodegenerative disorders such as Parkinson’s disease (PD). Inhibition of MAO-B may conserve dopamine in the brain, resulting in symptomatic relief of PD. Furthermore, inhibition of MAO-B may prevent the formation of neurotoxic metabolic products and thus MAO-B inhibitors may exert a neuroprotective effect. For these reasons, MAO-B inhibitors have been used as an
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Mejia, Jose. "Monoamine oxidases and aggressive behaviour : clinical studies and animal models." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38238.

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Monoamine oxidases (MAOs) are phylogenetically old enzymes which catalyze the deamination of monoamines. Interest in a relationship between MAO and aggressive behaviour derives from the report of a single family with a mutation which obliterates the activity of MAO A, as well as a long history of studies which substantiate a relationship between MAO activity and impulsive aggressive behaviour. The goals of this thesis were: (1) to examine the generalizability of the specific MAO mutation noted above; (2) to evaluate the relationship between platelet MAO activity and genetic polymorphisms in MA
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Villarinho, Jardel Gomes. "Avaliação do envolvimento da enzima monoamina oxidase b em modelos de dor pós-operatória e neuropática em camundongos." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/11124.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Monoamines appear to play an important modulatory role on pain descending pathways and are involved in the antinociceptive mechanism of several drugs commonly used for the management of pain. In this study, we assessed the involvement of monoamine oxidase B (MAO-B), a key enzyme implicated in monoamine metabolism, on models of postsurgical and neuropathic pain in mice. For this purpose, we evaluated the effects of the selective and irreversible MAO-B inhibitor selegiline on mechanical sensitivity and ex vivo MAO-B activity in diffe
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Mentz, Wayne. "Novel sulfanyl- and sulfinylcaffeine analogues as inhibitors of monoamine oxidase / Wayne Mentz." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9521.

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Parkinson’s disease (PD) is a neurodegenerative disorder, which is progressive in nature and usually associated with the elderly. It is the second most common age-related neurodegenerative disorder after Alzheimer’s disease (AD). PD occurs when there is a dramatic loss of dopamine (DA) in the striatum, a substructure of the basal ganglia, of the brain due to the degeneration of the nigrostriatal pathway that contains the dopaminergic neurons. Motor symptoms of PD include bradykinesia, muscular rigidity and resting tremors. Non-motor symptoms include speech and sleep problems, hallucinations an
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32

Tonello, Raquel. "AVALIAÇÃO DO POTENCIAL EFEITO ANTIDEPRESSIVO DO 2-BFI, LIGANTE IMIDAZOLÍNICO I2, EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/11190.

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Fundação de Amparo a Pesquisa no Estado do Rio Grande do Sul<br>Depression is a complex, chronic and disabling psychiatric disease that carries a high social cost. Among the various classes of antidepressants are the monoamine oxidase A (MAO-A) inhibitors that reduce monoamine metabolism. An important site of MAO-A regulation is the imidazoline-2 binding site (I2). In fact, it was recently shown that 2-imidazoline derivatives, such as 2-(2-benzofuranyl)-2-imidazoline (2- BFI), showed good potency and selectivity in inhibiting in vitro the activity of MAO-A, but the antidepressant potenti
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33

Pretorius, Anél. "The monoamine oxidase B substrate properties of selected pyrrolinyl analogues / Anél Pretorius." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4123.

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Mostert, Samantha. "Inhibition of monoamine oxidase by 8–[(phenylethyl)sulfanyl]caffeine analogues / Mostert S." Thesis, North-West University, 2012. http://hdl.handle.net/10394/8202.

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The oil and gas sector holds several advantages for South Africa: direct benefits include providing growth in the country’s economy by optimising available oil and gas resources and minimising dependence on foreign oil and gas exporting countries, while indirect advantages include fiscal rewards to the government, technological and infrastructural improvement, as well as benefits to society. However, the country’s oil and gas reserves are minimal in relation to several other countries worldwide, which is not beneficial for oil and gas ventures. Therefore, in the aim of promoting investment in
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35

Ratchford, Marie. "Platelet monoamine oxidase activity & antisocial behaviors a multi-faceted meta-analysis /." Tallahassee, Florida : Florida State University, 2009. http://etd.lib.fsu.edu/theses/available/etd-07152009-162324.

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Thesis (M.S.)--Florida State University, 2009.<br>Advisor: Kevin M. Beaver, Florida State University, College of Criminology and Criminal Justice, Dept. of Criminology and Criminal Justice. Title and description from dissertation home page (viewed on Nov. 13, 2009). Document formatted into pages; contains xi, 115 pages. Includes bibliographical references.
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Alaasam, Mohammed. "Identification of novel monoamine oxidase B inhibitors from ligand based virtual screening." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1405439915.

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37

Tra, Michelle. "Novel monoamine oxidase B inhibitor downregulation of lipopolysaccharide-induced pro-inflammatory cytokines." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54106.

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Oral inflammatory diseases (e.g. periodontitis) and gastrointestinal inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis) are characterized by an imbalance in secretion of pro- and anti-inflammatory cytokines leading to inflammation and epithelial and endothelial cell barrier disruption. Monoamine oxidase (MAO) B, a pro-oxidative enzyme, is induced in epithelial cells of a rat periodontal disease model and topical application of a known MAO inhibitor reduced disease (Ekuni et al., 2009). MAO B inhibitors also reduced TNFα secretion in epithelial cells and decreased endot
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Palmer, Sonya Lenette Jr. "The Investigation of the Active Sites of Monoamine Oxidase (MAO) A and B and the Study of MAO-A Mediated Neurotoxicity Using 4-Substituted Tetrahydropyridines." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30611.

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The mitochondrial membrane bound flavoenzymes monoamine oxidase A and B (MAO-A and MAO-B) catalyze the a-carbon oxidation of a variety of amines including neurotransmitters such as dopamine and serotonin. Although the primary structures of these enzymes have been established from the corresponding gene sequences, relatively little is known regarding the structural features of the active sites which lead to the selectivities observed with various substrates and inhibitors. In spite of many efforts, these enzymes have not been crystallized. In the absence of X-ray structures, the design, synt
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Balciuniene, Jorune. "Genetic studies of two inherited human phenotypes : Hearing loss and monoamine oxidase activity." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4917-4/.

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Van, den Berg Isabel Dedrieka. "Inhibition of monoamine oxidase B by substituted benzimidazole analogues / Deidré van den Berg." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1264.

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Both monoamine oxidase A and B (MAO-A and B) play an important role in the metabolism of monoamine neurotransmitters in the central nervous system (CNS) and are therefore of considerable pharmacological interest for the development of new drug therapies. Inhibitors of MA0 are of therapeutic interest for both the treatment of psychiatric and neurological diseases. Selective inhibitors of MAO-B are in use and are under investigation for the treatment of the symptoms and underlying neurodegeneration of Parkinson's disease (PD). PD is one of the most common neurological diseases of the elderly and
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Okaecwe, Thokozile Audrey Dorcas. "Inhibition of monoamine oxidase by selected 8-[(phenylsulfanyl)methyl]caffeine derivatives / Thokozile Okaecwe." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9187.

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Purpose Monoamine oxidase (MAO) consists of two isoforms, namely MAO-A and MAO-B. Both these isoforms are involved in the oxidation of dopamine. In Parkinson’s disease (PD) therapy, the inhibition of the oxidation of dopamine by MAO may elevate the levels of dopamine in the brain and prevent the generation of toxic by-products such as hydrogen peroxide. MAO-B inhibitors have found application as monotherapy in PD and it has been shown that MAO-B inhibitors may also be useful as adjuvants to L-dopa in PD therapy. For example, an earlier study has shown that the combination of L-dopa with (R)-de
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42

Pereira, Tamyris Paschoal. "Desenvolvimento de biossensor amperométrico baseado em monoamina oxidase-b para detecção de neurotransmissores." Universidade Federal de São Carlos, 2015. https://repositorio.ufscar.br/handle/ufscar/8798.

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Submitted by Milena Rubi (milenarubi@ufscar.br) on 2017-06-01T13:24:35Z No. of bitstreams: 1 PEREIRA_Tamyris_2015.pdf: 24726845 bytes, checksum: cad6e1bb20698eeb16bd6280b89c6c35 (MD5)<br>Approved for entry into archive by Milena Rubi (milenarubi@ufscar.br) on 2017-06-01T13:24:52Z (GMT) No. of bitstreams: 1 PEREIRA_Tamyris_2015.pdf: 24726845 bytes, checksum: cad6e1bb20698eeb16bd6280b89c6c35 (MD5)<br>Approved for entry into archive by Milena Rubi (milenarubi@ufscar.br) on 2017-06-01T13:24:59Z (GMT) No. of bitstreams: 1 PEREIRA_Tamyris_2015.pdf: 24726845 bytes, checksum: cad6e1bb20698eeb16bd6
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Moraes, Fernanda Pretto. "Computação biologicamente inspirada aplicada ao estudo da interação da monoamina oxidase e inibidores." Pontifícia Universidade Católica do Rio Grande do Sul, 2011. http://hdl.handle.net/10923/4534.

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Made available in DSpace on 2013-08-07T19:05:26Z (GMT). No. of bitstreams: 1 000436189-Texto+Completo-0.pdf: 18742545 bytes, checksum: 05749e4aa60fa43b373efcc6ee364d2a (MD5) Previous issue date: 2011<br>Parkinson's disease (PD) is a intriguing neurological disorder that affects the general population, attacking mainly in developing countries. This, it creates the need for discovery of therapeutic agents for the treatment of PD. Monoamine Oxidase (MAO) is an enzyme of major importance in neurochemistry, it catalyzes the oxidative deamination of biogenic amines, such as monoamine neurotransmit
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Park(Takao), Yoomi. "Monoamine oxidase A is highly expressed by the human corpus luteum of pregnancy." Kyoto University, 2009. http://hdl.handle.net/2433/124344.

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Pérez, Comisso Martín. "Aproximación cuántica de cluster para modelar los mecanismos de la Monoamino oxidasa A humana." Tesis, Universidad de Chile, 2013. http://repositorio.uchile.cl/handle/2250/138266.

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Magíster en Química y Memoria para optar al Título Profesional de Químico<br>La monoamino Oxidasa A humana es una enzima que metaboliza sustratos biogénicos como los neurotransmisores 5-HT, DA, NA, TA, entre otros. Existen diversas propuestas mecanísticas para la reacción de deaminación oxidativa de la hMAO-A: Polar nucleofílica, radicalaria, transferencia de hidruros. Todos estos mecánismos transfieren un hidruro (H􀀀) del Carbono alfa de la monoamina al N5 del anillo isoaloxacina. En este trabajo, se buscó por medio del Método de aproximación de clúster discriminar cuál es el mecanismo
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46

Gallardo, Godoy Alejandra. "Síntesis de derivados de feniletilamina como potenciales inhibidores de la enzima monoamino-oxidasa (MAO)." Tesis, Universidad de Chile, 2003. http://repositorio.uchile.cl/handle/2250/106713.

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47

Anderson, Andrea H. "Mechanistic Studies on the Monoamine Oxidase B Catalyzed Oxidation of 1,4-Disubstituted Tetrahydropyridine Derivatives." Diss., Virginia Tech, 1997. http://hdl.handle.net/10919/30566.

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The flavin-containing monoamine oxidases (MAO) A and B catalyze the oxidative deamination of primary and secondary amines. The overall process involves a two electron oxidation of the amine to the iminium with concomitantreduction of the flavin. Based on extensive studies with a variety of chemical probes, Silverman and colleagues have proposed a catalytic pathway for the processing of amine substrates and inactivators by MAO-B that is initiated by a single electron transfer (SET) step from the nitrogen lone pair to the oxidized flavin followed by a-proton loss from the resulting amine radica
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48

Salsali, Mahnaz. "Effects of the monoamine oxidase inhibitors, tranylcypromine and phenelzine, on selected cytochrome P450 enzymes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60342.pdf.

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49

Swanepoel, Abraham Johannes. "The synthesis and evaluation of phenoxymethylcaffeine analogues as inhibitors of monoamine oxidase / Braam Swanepoel." Thesis, North-West University, 2010. http://hdl.handle.net/10394/8428.

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Purpose: Monoamine oxidase (MAO) plays a key role in the treatment of Parkinson‟s disease (PD), since it is the major enzyme responsible for the catabolism of dopamine in the substantia nigra of the brain. Inhibition of MAO-B may conserve dopamine in the brain and provide symptomatic relief. The MAO-B inhibitors that are currently used for the treatment of PD, are associated with a variety of adverse effects (psychotoxic and cardiovascular effects) along with additional disadvantages such as irreversible inhibition of the enzyme. Irreversible inhibition may be considered a disadvantage, since
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Kalgutkar, Amit S. "Synthesis and biological evaluation of novel MPTP analogs as potential monoamine oxidase B inhibitors." Diss., This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-05222007-091412/.

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