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Journal articles on the topic 'Monoamino oxidase'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Shumakovich, G. P., L. G. Dubova, N. A. Byzova, A. I. Yaropolov, and S. O. Bachurin. "Efficient Artificial Electron Acceptors for Monoamino Oxidase in Bioelectrooxidation of Monoamines: Phenothiazine Dyes." Russian Journal of Electrochemistry 40, no. 9 (2004): 963–68. http://dx.doi.org/10.1023/b:ruel.0000041364.19078.e9.

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Muftin, Najlaa Qasim. "The Effect of Some Organic Compounds on Monoamino oxidase Activity." Journal of Al-Nahrain University Science 15, no. 4 (2012): 38–46. http://dx.doi.org/10.22401/jnus.15.4.05.

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3

Visciano, Pierina, Maria Schirone, and Antonello Paparella. "An Overview of Histamine and Other Biogenic Amines in Fish and Fish Products." Foods 9, no. 12 (2020): 1795. http://dx.doi.org/10.3390/foods9121795.

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The occurrence of biogenic amines in fish is directly associated with microorganisms with decarboxylase activity. These compounds are generally detoxified by oxidases in the intestinal tract of humans, but some conditions, such as alcohol consumption, enzyme deficiency, or monoamino-oxidase antidepressant use, can make their intake by food dangerous. Due to its toxicity, histamine is the unique biogenic amine with regulatory limits for fishery products. This review focuses on biogenic amines in fish, with a detailed picture of the number of alert notifications or intoxication events reported i

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4

SHRIMALI, M., R. KALSI, S. S. PARMAR, and J. P. BARTHWAL. "ChemInform Abstract: Monoamino Oxidase Inhibitory and Anticonvulsant Studies of Substituted 1,4-Benzodiazepines." ChemInform 22, no. 28 (2010): no. http://dx.doi.org/10.1002/chin.199128179.

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5

Otto, GP, M. Sossdorf, J. Lemm, S. Scholz, RA Claus, and M. Bauer. "Monoamino-oxidase-A function and potential benefit of its inhibition in sepsis." Critical Care 14, Suppl 2 (2010): P44. http://dx.doi.org/10.1186/cc9147.

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Nardi, Antonio Egidio. "O tratamento farmacológico da fobia social." Revista Brasileira de Psiquiatria 21, no. 4 (1999): 249–57. http://dx.doi.org/10.1590/s1516-44461999000400015.

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A fobia social é o medo acentuado e persistente de comer, beber, tremer, enrubescer, falar, escrever, enfim, de agir de forma ridícula ou inadequada na presença de outras pessoas. A fobia social apresenta-se em dois tipos básicos: a circunscrita, restrita a apenas um tipo de situação social, e a generalizada, caracterizada pelo temor a todas ou quase todas situações sociais. As características clínicas da fobia social são a ansiedade antecipatória, os sintomas físicos, a esquiva e a baixa auto-estima. Conforme o rigor diagnóstico, estima-se que 5% a 13% da população geral apresentem sintomas f

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Muftin, Najlaa Qassim, Emad Mahmoud Eltayef, Muna Khalil Murtadha, et al. "The effect of ginseng plant on the activity of monoamino oxidase and peroxidase." Annals of Tropical Medicine and Public Health 23, no. 07 (2020): 508–15. http://dx.doi.org/10.36295/asro.2020.23733.

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8

Brusnitsyn, D. V., E. P. Medyantseva, R. M. Varlamova, et al. "Carbon nanomaterials as electrode surface modifiers in development of amperometric monoamino oxidase biosensors." Inorganic Materials 52, no. 14 (2016): 1413–19. http://dx.doi.org/10.1134/s002016851614003x.

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9

VALOTI, M. "Interactions between tryptamine derived monoamino oxidase-inhibitors and rat liver cytochrome P-450." Pharmacological Research 26 (September 1992): 199. http://dx.doi.org/10.1016/1043-6618(92)91108-s.

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10

Molina, Enrique, Eduardo Sobarzo-Sanchez, Alejandro Speck-Planche, et al. "Monoamino Oxidase A: An Interesting Pharmacological Target for the Development of Multi-Target QSAR." Mini-Reviews in Medicinal Chemistry 12, no. 10 (2012): 947–58. http://dx.doi.org/10.2174/138955712802762383.

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11

Dosumu, Oluwatosin, Oluwafemi Owolabi, Regina Ugbaja, et al. "Administration of Cannabis causes alterations in monoamine oxidase B and serotonin receptor 2C gene expressions in Wistar rats." Acta Facultatis Medicae Naissensis 38, no. 1 (2021): 35–46. http://dx.doi.org/10.5937/afmnai38-28134.

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This study examined the probable effects of graded doses of Cannabis sativa (C. sativa) extract on the gene expressions of monoamine oxidase B and serotonin receptor 2C (HTR2C) in an attempt to correlate the duration of use with neurodegeneration tendencies in chronic marijuana users. Male Wistar rats weighing between 90 g ± 100 g were treated with graded doses of petroleum ether extract of C. sativa (12.5, 25 and 50 mg/kg body weight) orally. The exposure was monitored at 4, 8, and 12 weeks for each of the doses employed, after which the brain was removed. The gene expressions were determined

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Amr, Abd El-Galil E., Mohamed A. Al Omar, and Mohamed M. Abdalla. "Monoamino Oxidase Inhibitors Activities of Some Synthesized 2,6-bis (Tetracarboxamide)-pyridine and Macrocyclic Octacarboxamide Derivatives." International Journal of Pharmacology 12, no. 2 (2016): 66–73. http://dx.doi.org/10.3923/ijp.2016.66.73.

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13

Tyurin, V. A., A. D. Antipov, V. P. Chelomin, N. F. Avrova, and V. E. Kagan. "Protection from oxidative destruction of rat brain synaptosomal monoamino-oxidase by lipid and water soluble antioxidants." Neurochemistry International 21 (January 1992): B16. http://dx.doi.org/10.1016/0197-0186(92)92000-t.

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14

Nardi, Antonio E. "Antidepressants in social anxiety disorder." Arquivos de Neuro-Psiquiatria 59, no. 3A (2001): 637–42. http://dx.doi.org/10.1590/s0004-282x2001000400032.

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Social anxiety disorder (SAD) is a marked and persistent fear of doing almost everything in front of people due to concerns about being judge by others. An up-to-date review is needed in order to reach a practical judgement of all psychopharmacological data. Case reports, open and double-blind trials with SAD were described and commented upon from a clinical point of view. The MEDLINE system was searched from 1975 to 2001. The references from the selected papers were also used as a source. MAOIs (fenelzine, tranylcypromine), reversible monoamino oxidase-A inhibitors (moclobemide, brofaromine),

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15

Castelli, Francesco, Rosario Pignatello, Gioacchino Mazzone, Maria G. Sarpietro, Patrizia Mazzone, and Giuseppina Raciti. "Correlation between Monoamino Oxidase Inhibitor Activity of Some Thiazol-2-ylhydrazines and Their Interaction with Dipalmitoylphosphatidylcholine Liposomes." Journal of Pharmaceutical Sciences 83, no. 3 (1994): 362–66. http://dx.doi.org/10.1002/jps.2600830319.

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Gritsch, Sabine, Salvatore Guccione, RÉMy Hoffmann, Antonio Cambria, Giuseppina Raciti, and Thierry Langer. "A 3D QSAR Study of Monoamino Oxidase-B Inhibitors Using the Chemical Function Based Pharmacophore Generation Approach." Journal of Enzyme Inhibition 16, no. 3 (2001): 199–215. http://dx.doi.org/10.1080/14756360109162369.

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17

Ramesh, Muthusamy, and Arunachalam Muthuraman. "Quantitative Structure-Activity Relationship (QSAR) Studies for the Inhibition of MAOs." Combinatorial Chemistry & High Throughput Screening 23, no. 9 (2020): 887–97. http://dx.doi.org/10.2174/1386207323666200324173231.

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Monoamine oxidases are the crucial drug targets for the treatment of neurodegenerative disorders like depression, Parkinson’s disease, and Alzheimer’s disease. The enzymes catalyze the oxidative deamination of several monoamine containing neurotransmitters, i.e. serotonin (5-HT), melatonin, epinephrine, norepinephrine, phenylethylamine, benzylamine, dopamine, tyramine, etc. The oxidative reaction of monoamine oxidases results in the production of hydrogen peroxide that leads to the neurodegeneration process. Therefore, the inhibition of monoamine oxidases has shown a profound effect against ne

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Ilieva, Victoria, Magdalena Kondeva-Burdina, and Tzveta Georgieva. "In vitro analysis of the activity of human monoamine oxidase type B (hMAOB), treated with the cyanotoxin anatoxin-a: supposed factor of neurodegenerative diseases." Pharmacia 67, no. 2 (2020): 111–14. http://dx.doi.org/10.3897/pharmacia.67.e50806.

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In this study, we investigated the hypothesis that an additional source of free radicals may be hydrogen peroxide formed by monoamino oxidase (MAO) -catalyzed deamination of catecholamines. Also, increased MAO-B activity in the brain has been linked to the development of some neurodegenerative diseases. The toxicant we used to treat recombinant human MAO-B enzyme is the cyanotoxin аnatoxin-a. For anatoxin-a is known that it’s an agonist of neuronal acetylcholine receptors with 20 times greater affinity to them compared to the natural neurotransmitter. In this study, we analyzed the effect of a

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Vilamarim, Rafael, João Bernardo, Romeu A. Videira, Patrícia Valentão, Francisco Veiga, and Paula B. Andrade. "An egg yolk’s phospholipid-pennyroyal nootropic nanoformulation modulates monoamino oxidase-A (MAO-A) activity in SH-SY5Y neuronal model." Journal of Functional Foods 46 (July 2018): 335–44. http://dx.doi.org/10.1016/j.jff.2018.05.009.

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20

Williams, C. H., J. Lawson, and F. R. C. Backwell. "Oxidation of 3-amino-1-phenylprop-1-enes by monoamine oxidase and their use in a continuous assay of the enzyme." Biochemical Journal 256, no. 3 (1988): 911–15. http://dx.doi.org/10.1042/bj2560911.

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3-Amino-1-phenylprop-1-ene (cinnamylamine) and some derivatives were examined as substrates for monoamine oxidases A and B in mitochondria. All of the amines examined were readily oxidized by monoamine oxidase B but much less readily by monoamine oxidase A. E-Cinnamylamine was found to have Km 0.025 mM and Vmax. 3.9 nmol/min per mg of mitochondrial protein. Corresponding values with monoamine oxidase A were 0.026 mM and 0.85 nmol/min per mg respectively. Despite their different stereochemistry, E- and Z-N-methylcinnamylamines were almost equally effective as substrates for monoamine oxidase B.

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21

Seiler, Nikolaus, Jacques-Philippe Moulinoux, Rene Havouis, and Louis Toujas. "Characterization of amine oxidase activities in macrophages from human peripheral blood." Biochemistry and Cell Biology 73, no. 5-6 (1995): 275–81. http://dx.doi.org/10.1139/o95-034.

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A sensitive assay for the determination of hydrogen peroxide formation and a method for the identification and characterization of amine oxidases in cells and other oxidase sources of limited accessibility are described. The enzymes are characterized by substrate and inhibitor patterns. The method was applied to the identification and characterization of polyamine oxidizing enzymes in macrophages from human peripheral blood. The major oxidase activity in these cells was found to be a tissue-type polyamine oxidase, but with distinct characteristics. Diamine oxidase and monoamine oxidase activit

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22

Aksoz, Begum E., and Erkan Aksoz. "Vital Role of Monoamine Oxidases and Cholinesterases in Central Nervous System Drug Research: A Sharp Dissection of the Pathophysiology." Combinatorial Chemistry & High Throughput Screening 23, no. 9 (2020): 877–86. http://dx.doi.org/10.2174/1386207323666200220115154.

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Background: Monoamine oxidase and cholinesterase enzymes are very critical enzymes that regulate the level of neurotransmitters such as acetylcholine and monoamines. Monoamine neurotransmitters and acetylcholine play a very important role in many physiological events. An increase or decrease in the amount of these neurotransmitters is observed in a wide range of central nervous system pathologies. Balancing the amount of these neurotransmitters is important in improving the progression of these diseases. Inhibitors of monoamine oxidase and cholinesterase enzymes are important in symptomatic th

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23

Nag, S., L. Lehmann, G. Kettschau, et al. "Development of a novel fluorine-18 labeled deuterated fluororasagiline ([18F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B)." Bioorganic & Medicinal Chemistry 21, no. 21 (2013): 6634–41. http://dx.doi.org/10.1016/j.bmc.2013.08.019.

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24

Krueger, M. J., K. McKeown, R. R. Ramsay, S. K. Youngster, and T. P. Singer. "Mechanism-based inactivation of monoamine oxidases A and B by tetrahydropyridines and dihydropyridines." Biochemical Journal 268, no. 1 (1990): 219–24. http://dx.doi.org/10.1042/bj2680219.

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its primary oxidation product, 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+), are mechanism-based inhibitors of monoamine oxidases A and B. The pseudo-first-order rate constants for inactivation were determined for various analogues of MPTP and MPDP+ and the concentrations in all redox states were measured throughout the reaction. Disproportionation was observed for all the dihydropyridiniums, but non-enzymic oxidation was insignificant. The dihydropyridiniums were poor substrates for monoamine oxidase A and, consequently, inactivated t

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25

Oliveira-Souza, Ricardo de, and Wagner Martignoni de Figueiredo. "Apatia multimodal iatrogênica." Arquivos de Neuro-Psiquiatria 54, no. 2 (1996): 216–21. http://dx.doi.org/10.1590/s0004-282x1996000200007.

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O presente trabalho documenta um efeito peculiar dos antidepressivos em 5 pacientes - a apatia -, definida pela incapacidade de experimentar emoções. O reconhecimento da apatia no curso de tratamento antidepressivo deve levantar a possibilidade de iatrogenia e suspensão do antidepressivo em uso. Frizamos que a apatia deve ser diferenciada da abulia e da avolição, com as quais é comumente contundida. Documentamos que a indiferença emocional pode se confinar a um domínio sensorial ("apatia unimodal") ou, como em nossos casos, a mais de uma modalidade ("apatia multimodal"). Circuitos anterobasais

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26

Qiu, Jingying, Chengjiang Li, Zhichun Dong, and Jing Wang. "Anti-diabetic effect of a monoamine oxidase inhibitor (tranylcypromine) in rats with poorly-controlled blood glucose levels: A potential and novel therapeutic option for diabetes." Tropical Journal of Pharmaceutical Research 19, no. 6 (2020): 1249–54. http://dx.doi.org/10.4314/tjpr.v19i6.20.

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Purpose: To determine the anti-diabetic effect of a monoamine oxidase inhibitor (tranylcypromine) in sulphonyl urea-refractory rats with poorly-controlled blood glucose levels.Methods: Alloxan-induced diabetic Wistar rats were assigned to two groups (30 rats/group). One group received glibenclamide at a dose of 0.6 mg/kg, while the other group was given monoamine oxidase inhibitor (tranylcypromine) at a dose of 5 mg/day. The two groups were treated for 2 weeks. Blood samples were collected at baseline (before treatment) and at the end of treatment for determination of plasma glucose (fasting a

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Zhou, Shi-Sheng, Yi-Ming Zhou, Da Li, and Qiang Ma. "Early Infant Exposure to Excess Multivitamin: A Risk Factor for Autism?" Autism Research and Treatment 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/963697.

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Autism, a neurodevelopmental disorder that affects boys more than girls, is often associated with altered levels of monoamines (serotonin and catecholamines), especially elevated serotonin levels. The monoamines act as both neurotransmitters and signaling molecules in the gastrointestinal and immune systems. The evidence related to monoamine metabolism may be summarized as follows: (i) monoamine neurotransmitters are enzymatically degraded/inactivated by three mechanisms: oxidative deamination, methylation, and sulfation. The latter two are limited by the supply of methyl groups and sulfate, r

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Yu, Peter H. "Three types of stereospecificity and the kinetic deuterium isotope effect in the oxidative deamination of dopamine as catalyzed by different amine oxidases." Biochemistry and Cell Biology 66, no. 8 (1988): 853–61. http://dx.doi.org/10.1139/o88-097.

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When the stereospecifically deuterated dopamine enantiomers, (R)- and (S)-[α-2H1]dopamine, are incubated with amine oxidases, the deuterium atom may be either retained to form monodeuterated 3,4-dihydroxyphenylacetaldehyde, or eliminated to produce the nondeuterated or protio-aldehyde product. These two aldehydes can be separated from one another and identified by high-performance liquid chromatography with electrochemical detection. Three types of stereospecific abstraction of a hydrogen from the α-carbon of dopamine during deamination have been observed. In the first type, the pro-R hydrogen

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Huang, Yu-Hong, Akio Ito, and Ryohachi Arai. "Immunohistochemical Localization of Monoamine Oxidase Type B in Pancreatic Islets of the Rat." Journal of Histochemistry & Cytochemistry 53, no. 9 (2005): 1149–58. http://dx.doi.org/10.1369/jhc.5a6658.2005.

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Monoamine oxidase (MAO) is regarded as a mitochondrial enzyme. This enzyme localizes on the outer membrane of mitochondria. There are two kinds of MAO isozymes, MAO type A (MAOA) and type B (MAOB). Previous studies have shown that MAOB activity is found in the pancreatic islets. This activity in the islets is increased by the fasting-induced decrease of plasma glucose level. Islet B cells contain monoamines in their secretory granules. These monoamines inhibit the secretion of insulin from the B cells. MAOB is active in degrading monoamines. Therefore, MAOB may influence the insulin-secretory

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Olaya, María del Pilar, Nadezdha Esperanza Vergel, José Luis López, María Dolores Viña, and Mario Francisco Guerrero. "Coumarin analogue 3-methyl-7H-furo[3,2-g] chromen-7-one as a possible antiparkinsonian agent." Biomédica 39, no. 3 (2019): 491–501. http://dx.doi.org/10.7705/biomedica.4299.

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Introduction: Parkinson’s disease is the second most common neurodegenerative disease. Monoamine oxidase B inhibitors are used in the treatment of this disease concomitantly with levodopa or as monotherapy. Several substituted coumarins have shown activity as inhibitors of monoamine oxidase B.Objective: To evaluate the possible antiparkinsonian effects of the coumarin analogue FCS005 (3-methyl-7H-furo[3,2-g]chromen-7-one) in mouse models, as well as its inhibitory activity towards monoamine oxidases (MAO) and its antioxidant activity.Materials and methods: FCS005 was synthesized and the revers

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Levitan, Michelle N., Marcos H. N. Chagas, José A. S. Crippa, et al. "Diretrizes da Associação Médica Brasileira para o tratamento do transtorno de ansiedade social." Revista Brasileira de Psiquiatria 33, no. 3 (2011): 292–302. http://dx.doi.org/10.1590/s1516-44462011000300014.

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INTRODUÇÃO: O transtorno de ansiedade social (TAS) é o transtorno de ansiedade mais comum, freqüentemente sem remissões, sendo comumente associado com importante prejuízo funcional e psicossocial. A Associação Médica Brasileira (AMB), através do "Projeto Diretrizes", busca desenvolver consensos de diagnóstico e tratamento para as doenças mais comuns. O objetivo deste trabalho é apresentar os achados mais relevantes das diretrizes relativas ao tratamento do TAS, servindo de referência para o médico generalista e especialista. MÉTODO: O método utilizado foi o proposto pela AMB. A busca foi reali

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Ramsay, Rona R., and Alen Albreht. "Questions in the Chemical Enzymology of MAO." Chemistry 3, no. 3 (2021): 959–78. http://dx.doi.org/10.3390/chemistry3030069.

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We have structure, a wealth of kinetic data, thousands of chemical ligands and clinical information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have comparative information from various species and mutations on kinetics and effects of inhibition. Nevertheless, there are what seem like simple questions still to be answered. This article presents a brief summary of existing experimental evidence the background and poses questions that remain intriguing for chemists and biochemists researching the chemical enzymology of and drug design for monoamine oxidases (FAD

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33

Martin-Iverson, Mathew T., and Bruce A. Lodge. "Effects of chronic treatment of rats with "designer" amphetamines on brain regional monoamines." Canadian Journal of Physiology and Pharmacology 69, no. 12 (1991): 1825–32. http://dx.doi.org/10.1139/y91-270.

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(+)-Amphetamine and two structurally related analogues, 4-methoxyamphetamine and a recent "designer drug," 4-ethoxy-amphetamine, were given to rats via subcutaneous osmotic minipumps for 1–14 days. Regional brain levels of the drugs as well as monoamine neurotransmitters and some of their major acidic metabolites were determined. Amphetamine produced depletions of dopamine in the striatum after at least 3 days of treatment but not in the nucleus accumbens or olfactory tubercle, even after 14 days of treatment. In contrast, the two ring-substituted amphetamine analogues increased levels of the

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Cha, Yoon Jin, Woo Hee Jung, and Ja Seung Koo. "Site-specific expression of amine oxidases in breast cancer metastases." Tumor Biology 40, no. 5 (2018): 101042831877682. http://dx.doi.org/10.1177/1010428318776822.

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We aimed to evaluate the expression of amine oxidase-related proteins in metastatic breast cancer tissue and determine its clinical implication. A tissue microarray was constructed from a total of 126 metastatic breast tumors (31 bone metastases (24.6%), 36 brain metastases (28.6%), 11 liver metastases (8.7%), and 48 lung metastases (38.1%)). Immunohistochemical staining for amine oxidase-related proteins (lysyl oxidase, diamine oxidase, and monoamine oxidase A and B) was performed. In metastatic breast cancer tissue, lysyl oxidase ( p = 0.001), tumoral diamine oxidase ( p = 0.003), stromal di

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Cai, Lu, Chao Wang, Xiao-kui Huo, et al. "Effect of Alkaloids Isolated fromPhyllodium pulchellumon Monoamine Levels and Monoamine Oxidase Activity in Rat Brain." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6826175.

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Phyllodium pulchellum(P. pulchellum) is a folk medicine with a significant number of bioactivities. The aim of this study was to investigate the effects displayed by alkaloids fractions, isolated from the roots ofP. pulchellum, on neurotransmitters monoamine levels and on monoamine oxidase (MAO) activity. Six alkaloids, which had indolealkylamine orβ-carboline skeleton, were obtained by chromatographic technologies and identified by spectroscopic methods such as NMR and MS. After treatment with alkaloids ofP. pulchellum, the reduction of DA levels (54.55%) and 5-HT levels (35.01%) in rat brain

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Petkov, V. D., S. L. Stancheva, V. V. Petkov, and L. G. Alova. "Age-related changes in brain biogenic monoamines and monoamine oxidase." General Pharmacology: The Vascular System 18, no. 4 (1987): 397–401. http://dx.doi.org/10.1016/0306-3623(87)90097-8.

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Haefely, Willy, Mosé da Prada, Rolf Kettler, Hans H. Keller, and Willy P. Burkard. "Pre-clinical Pharmacology of Moclobemide." British Journal of Psychiatry 155, S6 (1989): 84–88. http://dx.doi.org/10.1192/s0007125000297547.

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The novel antidepressant, moclobemide, is a reversible inhibitor of monoamine oxidase (MAO) preferentially of monoamine oxidise-A (MAO-A); it emerged for study out of a series of lipid-lowering agents. In spite of its weak MAO-A inhibition in vitro, moclobemide is a potent inhibitor of MAO-A, in vivo; its in vivo activity is of short duration, in contrast to the extremely long-lasting inhibition, e.g. by tranylcypromine. Moclobemide only slightly potentiates the pressor effect of oral tyramine in freely moving rats, again in contrast to tranylcypromine; it is not anti-cholinergic and is free o

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Inyushin, M. Y., A. Huertas, Y. V. Kucheryavykh, et al. "L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain." Parkinson's Disease 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/321406.

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Astrocyte endfeet surround brain blood vessels and can play a role in the delivery of therapeutic drugs for Parkinson’s disease. However, there is no previous evidence of the presence of LAT transporter forL-DOPA in brain astrocytes except in culture. Using systemicL-DOPA administration and a combination of patch clamp, histochemistry and confocal microscopy we found thatL-DOPA is accumulated mainly in astrocyte cell bodies, astrocytic endfeet surrounding blood vessels, and pericytes. In brain slices: (1) astrocytes were exposed to ASP+, a fluorescent monoamine analog of MPP+; (2) ASP+taken up

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Hollander, Eric. "Parkinson's Disease, Tourette Syndrome, and the Changing Nature of Depression: The Dog Days of Summer." CNS Spectrums 13, no. 8 (2008): 643–44. http://dx.doi.org/10.1017/s1092852900013729.

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Since the development of selective serotonin reuptake inhibitors there has been a widening of the definition of depression and a decrease in the placebo-drug difference in controlled studies. In the early 1960s, ~33% of depressed patients improved with placebo and 66% with active compounds and current controlled studies suggest that the situation has certainly not improved. The Sequenced Treatment Alternatives to Relieve Depression Study found that response rates to new compounds after the failure of the first antidepressant are low. The monoamine hypothesis of depression was formulated in the

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Belmaker, Robert H. "The Future of Depression Psychopharmacology." CNS Spectrums 13, no. 8 (2008): 682–87. http://dx.doi.org/10.1017/s1092852900013766.

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ABSTRACTAlong with the development of selective sertonin reuptake inhibitors there has been a tremendous widening of the definition of depression and an impressive decrease in the placebodrug difference in controlled studies. In the early 1960s, about one third of depressed patients improved with placebo and two thirds with active compounds. Current controlled studies suggest that the situation has certainly not improved. The Sequenced Treatment Alternatives to Relieve Depression Study found that response rates to new compounds after the failure of the first antidepressant are low. The monoami

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Niu, Tianjiao, Xing Li, Yongjie Guo, and Ying Ma. "Identification of a Lactic Acid Bacteria to Degrade Biogenic Amines in Chinese Rice Wine and Its Enzymatic Mechanism." Foods 8, no. 8 (2019): 312. http://dx.doi.org/10.3390/foods8080312.

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A L. plantarum, CAU 3823, which can degrade 40% of biogenic amines (BAs) content in Chinese rice wine (CRW) at the end of post-fermentation, was selected and characterized in this work. It would be an optimal choice to add 106 cfu/mL of selected strain into the fermentation broth to decrease the BAs while keeping the character and quality of CRW. Nine amine oxidases were identified from the strain and separated using Sephadex column followed by LC-MS/MS analysis. The purified amine oxidase mixture showed a high monoamine oxidase activity of 19.8 U/mg, and more than 40% of BAs could be degraded

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Pereira, Ana, Camila Guimarães, Sarazete Pereira, et al. "Isolation and Identification of Phenylethanoid Glycosides from Aloysia polystachya and Its Activity as Inhibitors of Monoamine Oxidase-A." Planta Medica International Open 6, no. 01 (2019): e1-e6. http://dx.doi.org/10.1055/a-0787-1665.

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Abstract Aloysia polystachya is used as a sedative and antidepressant by the indigenous populations of Argentina and Paraguay, but the compounds associated with these activities have not been determined. We have separated and identified the main constituents of the hydroethanolic extract of A. polystachya by ultra-performance liquid chromatography-mass spectrometry and confirmed the presence of acteoside, isoacteoside, 6'-acetylacteoside, and 4’,4’’’,5,5’’-tetrahydroxy-6,6’’,3’’’-trimethoxy-[C7–O–C7’’]-biflavone by NMR spectroscopy. Inhibitory activities of the hydroethanolic extract and purif

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Abidi, S. M. A., and W. A. Nizami. "Monoamine oxidase in amphistomes and its role in worm motility." Journal of Helminthology 74, no. 4 (2000): 283–88. http://dx.doi.org/10.1017/s0022149x0000041x.

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AbstractThe quantitative assay of mitochondrial monoamine oxidase (MAO) activity revealed a higher enzyme level in Explanatum explanatum than Gastrothylax crumenifer. The specific MAO inhibitors, chlorgyline, pargyline, deprenyl and nialamide produced different degrees of interspecific inhibition. The differential effects on enzyme activity of chlorgyline and deprenyl suggests the possible existence of polymorphic forms of the enzyme, MAO-A and MAO-B, in amphistomes. These specific inhibitors also had a differential influence on the in vitro motility of amphistomes, further indicating the invo

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Wu, Ying-Hui, Matthijs G. P. Feenstra, Jiang-Ning Zhou, et al. "Molecular Changes Underlying Reduced Pineal Melatonin Levels in Alzheimer Disease: Alterations in Preclinical and Clinical Stages." Journal of Clinical Endocrinology & Metabolism 88, no. 12 (2003): 5898–906. http://dx.doi.org/10.1210/jc.2003-030833.

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Abstract A disturbed sleep-wake rhythm is common in Alzheimer disease (AD) patients and correlated with decreased melatonin levels and a disrupted circadian melatonin rhythm. Melatonin levels in the cerebrospinal fluid are decreased during the progression of AD neuropathology (as determined by the Braak stages), already in cognitively intact subjects with the earliest AD neuropathology (Braak stages I-II) (preclinical AD). To investigate the molecular mechanisms behind the decreased melatonin levels, we measured monoamines and mRNA levels of enzymes of the melatonin synthesis and its noradrene

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Oreland, L., N. Nordquist, J. Hallman, J. Harro, and K. W. Nilsson. "Environment and the serotonergic system." European Psychiatry 25, no. 5 (2010): 304–6. http://dx.doi.org/10.1016/j.eurpsy.2009.12.017.

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AbstractIn summary, genetics, as well as foetal and early life environmental factors shape the size or capacity of our monoamine systems, of which the serotonergic one might play a leading role. Those constitutional properties then form the biological basis for personality traits, such as impulsiveness and “sensation seeking”, which interact with psychosocial settings and life events to form a pattern of reactivity to a current life event or psychosocial situation, shown as a high or low order of magnitude of gene-environment interaction. In the present paper emphasis is put on the role of gen

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Carpéné, Christian, Nathalie Boulet, Alice Chaplin, and Josep Mercader. "Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors." Medicines 6, no. 1 (2019): 9. http://dx.doi.org/10.3390/medicines6010009.

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Background: Two classes of amine oxidases are found in mammals: those with a flavin adenine dinucleotide as a cofactor, such as monoamine oxidases (MAO) and lysine-specific demethylases (LSD), and those with copper as a cofactor, including copper-containing amine oxidases (AOC) and lysyl oxidases (LOX). All are expressed in adipose tissue, including a semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) strongly present on the adipocyte surface. Methods: Previously, irreversible MAO inhibitors have been reported to limit food intake and/or fat extension in rodents; ho

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&NA;. "Monoamine oxidase inhibitors." Reactions Weekly &NA;, no. 365 (1991): 10. http://dx.doi.org/10.2165/00128415-199103650-00052.

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Livingston, Martin G., and Hilary M. Livingston. "Monoamine Oxidase Inhibitors." Drug Safety 14, no. 4 (1996): 219–27. http://dx.doi.org/10.2165/00002018-199614040-00002.

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Volz, Hans-Peter, and Christoph H. Gleiter. "Monoamine Oxidase Inhibitors." Drugs & Aging 13, no. 5 (1998): 341–55. http://dx.doi.org/10.2165/00002512-199813050-00002.

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Elliot‐Baker, Stuart. "Monoamine oxidase inhibitors." Medical Journal of Australia 147, no. 6 (1987): 315. http://dx.doi.org/10.5694/j.1326-5377.1987.tb133500.x.

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