Relevant bibliographies by topics / Monoclonal antibodies ; Immunotherapy / Dissertations / Theses
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Dissertations / Theses on the topic 'Monoclonal antibodies ; Immunotherapy'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 February 2022

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1

Thomas, Myles Duncan. "Production and characterisation of novel human monoclonal antibodies against malignant melanoma." Thesis, University of East London, 1995. http://roar.uel.ac.uk/1275/.

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Malignant melanoma is an immunogenic tumour capable of inducing a humoral immune response, as shown by tumour-reactive serum antibody in patients. Lack of effective chemotherapy in association with the immunogenic nature of the malignancy, has stimulated interest in the immunological management of the malignancy by antibody. Many mouse monoclonal antibodies against melanoma antigens have been developed, and some have been shown to induce tumour regression. However, a limitation on the use of mouse monoclonal antibodies in patients is the induction of an immune response against the immunising x
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2

Saxena, Abhishek. "Construction of immune scFv M13 phage display library and isolation of anti-glycan monoclonal antibodies." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203295.

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3

Sandin, Linda. "Immunomodulatory Therapy of Solid Tumors : With a Focus on Monoclonal Antibodies." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210080.

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Cancer, historically considered a genetic disease, is currently acknowledged to affect the whole body. Our immune system is one key player that can elicit a response against malignant cells but can also promote tumorigenesis. Tumors avoid immune recognition by creating a suppressive microenvironment and inducing tolerance. T-cells are regarded a major effector cell type in tumor immunotherapy. An important ”switch” needed for T-cell activation involves so-called costimulatory and coinhibitory receptors. In this thesis, experimental tumor models were used to investigate the potential of immunom
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4

DIAS, CARLA R. de B. R. "Estudo comparativo da marcacao do anticorpo anti-CD20 com sup(188)Re." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9502.

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Made available in DSpace on 2014-10-09T12:27:22Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:06:35Z (GMT). No. of bitstreams: 0<br>Tese (Doutoramento)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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5

Beckwith, Kyle Addison. "Novel Immunotherapeutic Strategies for Chronic Lymphocytic Leukemia." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461203257.

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6

Brunel, Simon. "Immunothérapie du cancer par administration d’anticorps monoclonaux anti-HVEM ou anti-ICOS chez la souris humanisée : potentiel thérapeutique et effets immunologiques." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066215.

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Un nouveau couple de récepteurs de co-signalisation (BTLA/HVEM) a récemment été proposé comme un acteur important dans l’échappement tumoral. L'expression d’HVEM a été identifiée dans la plupart des cancers. Son niveau expression est inversement corrélé avec la survie des patients. L'expression d’HVEM par des cellules tumorales pourrait inhiber la réponse immunitaire à travers BTLA exprimé par les lymphocytes T.Ainsi, dans notre travail, des anticorps monoclonaux (mAb) ciblant HVEM ont été évalués dans un modèle de souris NSG greffées avec des lymphocytes T et des tumeurs humaines. Nous avons
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7

Rossmann, Eva D. "Targets for immune mediated killing of tumor cells and T cell functions in B-CLL /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-622-7/.

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8

Mendes, Priscila Fraga Penteado [UNIFESP]. "Identificação, por anticorpo monoclonal, de proteína de 230 kDa relacionada com malignidade em melanoma murino." Universidade Federal de São Paulo (UNIFESP), 2006. http://repositorio.unifesp.br/handle/11600/9703.

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Made available in DSpace on 2015-07-22T20:50:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-12-31<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Melanomas se destacam entre os tumores sólidos por apresentar alto potencial de malignidade e incidência crescente, especialmente entre indivíduos jovens. Identificação de marcadores moleculares em melanomas é de enorme interesse para uso clínico e para estudos relacionados ao seu desenvolvimento. A linhagem de melanoma murino B16 tem sido
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9

Gustafsson, Liljefors Maria. "Immunotherapy with the anti-EpCAM monoclonal antibody and cytokines in patients with colorectal cancer : a clinical and experimental study /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-499-6/.

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10

Javidipoor, Moossa. "Production and Characterization of Monoclonal Antibodies Against Murine P388D1 Leukemia Cells for Evaluation of Immunotherapy in Tumor Bearing DBA/2 Mice." NSUWorks, 1986. http://nsuworks.nova.edu/occ_stuetd/59.

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The objective of these studies was to produce monoclonal antibodies against P388Dl cells, a lymphocytic leukemia of murine origin, to evaluate the efficacy of immunotherapy in tumor bearing DBA/2 mice. Hybridomas producing anti-P388Dl MAbs were obtained by fusion between Sp2/0 myeloma and irrununized BALB/c spleen cells. Monoclonal antibodies were screened by enzyme linked immunoabsorbent and radioimmunoassays, and positive hybridomas were cloned and further subcloned by limiting dilution in fluid phase. Four subclones designated G10, C9, C7, and D11 showed significant binding to both solubili
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11

Jneid, Bakhos. "Evaluation de l’effet protecteur de protéines du système de sécrétion de type III de bactéries entéropathogènes pour la vaccination et l’immunothérapie." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS578/document.

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Les bactéries entéropathogènes du genre Salmonella et Shigella sont transmises par les aliments ou l’eau et sont responsables de nombreuses infections entériques chez les animaux et les humains. Ces maladies infectieuses restent une cause importante de morbidité et de mortalité dans les pays en voie de développement. L’existence de multiples sérotypes de Salmonella et de Shigella ainsi que l’émergence de souches résistantes aux antibiotiques, nécessite le développement de vaccins efficaces et large spectre. Ces bactéries utilisent un système d’injection de leurs protéines effectrices, appelé i
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12

Jimenez, Jeffy Pilar. "Effects of Monoclonal Anti-Abeta Antibodies on the Amyloid Beta Peptide Fibrillogenesis and their Involvement in the Clearance of Alzheimer's Disease Plaques." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3445.

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Alzheimer’s disease (AD) is the most common cause of senile dementia worldwide. AD is a neurodegenerative disorder characterized by the loss of memory and language skill, collapse of the cognitive function, and distortion of social behavior. As of today, the onset mechanisms of AD and cure are unknown; however, three hallmarks are commonly encountered: extra and intracellular accumulation of amyloid beta (A!) peptide plaques, formation of intracellular neurofibrillary tangles, and inevitable neuronal death. Hypothetically, a possible scenario provoking or involved in the onset of AD is a casca
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13

Mediouni, Sonia. "Etude par des anticorps de patients VIH-1 de la protéineTAT extracellulaire et développement thérapeutique." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20712.

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La protéine Tat (Trans-activator of transcription) est certainement l’une des cibles présentant le plus d’intérêts dans la lutte contre le VIH-1. En effet, synthétisée précocement, elle joue un rôle central dans le cycle viral et protège les cellules infectées. Secrétée dans le milieu extracellulaire, elle participe à l’immunodéficience en inhibant certaines fonctions ou en induisant l’apoptose des cellules du système immunitaire. Elle est également impliquée directement dans de nombreuses pathologies associées au VIH-1. Dans une première étude, nous avons voulu savoir si la trithérapie était
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14

Prampero, Anna Carolina. "Produção de anticorpos monoclonais anti-GITR e anti-CD25 através de cultivo de hibridomas e comparação do seu potencial como agentes antitumorais." Universidade Federal de São Carlos, 2017. https://repositorio.ufscar.br/handle/ufscar/9210.

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Submitted by Aelson Maciera (aelsoncm@terra.com.br) on 2017-10-06T18:08:45Z No. of bitstreams: 1 DissACP.pdf: 6605106 bytes, checksum: c63dcdec106579e271edaa4dc5a8bdcf (MD5)<br>Approved for entry into archive by Ronildo Prado (bco.producao.intelectual@gmail.com) on 2017-11-28T12:14:39Z (GMT) No. of bitstreams: 1 DissACP.pdf: 6605106 bytes, checksum: c63dcdec106579e271edaa4dc5a8bdcf (MD5)<br>Approved for entry into archive by Ronildo Prado (bco.producao.intelectual@gmail.com) on 2017-11-28T12:14:55Z (GMT) No. of bitstreams: 1 DissACP.pdf: 6605106 bytes, checksum: c63dcdec106579e271edaa4dc5a
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15

Oliveira, Raquel Faria. "Immunotherapy for Alzheimers’ Disease." Master's thesis, 2013. http://hdl.handle.net/10451/46044.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2013<br>Alzheimers’ Disease (AD) is the most common form of dementia and normally begins with deterioration in memory, leading to a progressive decline in function and cognition. The pathogenesis of the disease lies in the extracellular deposition of the amyloid-β (Aβ) protein in cerebral tissues and the intracellular accumulation of hyperphosphorylated tau-protein as Neurofibrillary Tangles (NFTs). Both situations lead to neurodegenerative processes characteristic in AD. Immunotherapy
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16

Lawson, Maxx. "Modulating the T cell response: using anti-interleukin-7 receptor-alpha monoclonal antibodies with autoantigen-specific immunotherapy to prevent type-1-diabetes." Thesis, 2019. https://hdl.handle.net/2144/37107.

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Autoimmunity develops over an extended period of time as the result of an amalgamation of genetic, environmental, and immunologic events. Though the precise etiological factors leading to most autoimmune disease are awaiting consensus, a common thread of the autoimmune paradigm is the inappropriate activation of tissue-specific immune cells by one or more autoantigen, which begins the destruction of the tissue. To prohibit immunopathology and fine-tune the immune responses in healthy individuals, the stimulatory activities of effector/memory T (Teffs) cells must be counteracted by the suppress
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17

Ribeiro, Pedro Alexandre Rasteiro. "Imunoterapia no Cancro da Bexiga localmente avançado ou metastizado." Master's thesis, 2018. http://hdl.handle.net/10316/81858.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: Após vários anos, sem avanços na abordagem de doentes com Cancro da Bexiga (BC) localmente avançado ou metastizado, especialmente assente na quimioterapia à base de platino, a escassez de resultados e o seu impacto reduzido na sobrevivência e no prognóstico destes doentes têm motivado a crescente investigação nesta área. Objetivo: Reconhecer quais as alternativas farmacológicas existentes atualmente em imunoterapia, para o tratamento do BC localmente avançado ou metastizado, suas particularidade
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18

Lopes, Sara Catarina Tavares. "Internship reports and Monograph entitled: "Monoclonal Antibodies for Alzheimer`s disease treatment: Current Status and Future Perspectives"." Master's thesis, 2017. http://hdl.handle.net/10316/83729.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>A doença de Alzheimer é uma doença neurodegenerativa, progressiva, multifatorial, incurávelconsiderada a causa mais comum de demência e com prognóstico desfavorável. É caracterizada por um desequilíbrio entre a quantidade de proteínas β-amiloídes e proteínas TAU produzidas e eliminadas. O tratamento atual da doença é essencialmente sintomático, usando inibidores da colinesterase e Memantina, atuando sobre o sistema glutaminérgico. Nenhum medicamento novo foi aprovado para o tratamento da
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19

Ramalho, Helga Maria Steig. "Imunoterapia: novo paradigma para tratamento de cancro oral." Master's thesis, 2016. http://hdl.handle.net/10284/5759.

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O cancro oral é uma neoplasia maligna relativamente frequente, sendo por isso responsável por uma taxa de mortalidade elevada. Em particular, o carcinoma espinocelular é o tipo histológico mais frequente das neoplasias malignas da cavidade oral, estando claramente associada a factores de risco como o tabaco, o consumo de álcool e a infecção pelo vírus do papiloma humano (HPV). Actualmente, no mundo ocidental, observa-se um aumento na incidência do cancro da língua que parece estar relacionado com infecções pelos vírus HPV. Tendo em conta os fenómenos associados à cancerização da mucosa oral e
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