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Journal articles on the topic 'Monoclonal'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Ernestho-ghoud, Indretsy Mahavivola, Moustafa Abdou Soilihi, Ny Ony Narindra Lova Hasina Rajaonarison, Nasolotsiry Enintsoa Raveloson, Ahmad Ahmad, and Hanta Marie Danielle Vololontiana. "Association entre gammapathie monoclonale de signification indéterminée et thrombose veineuse cérébrale : Une observation clinique inhabituelle." Annales Africaines de Medecine 16, no. 3 (2023): 5244–48. http://dx.doi.org/10.4314/aamed.v16i3.10.

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Cerebral venous thrombosis associated to the monoclonal gammopathy of undetermined significance has been rarely reported. In this paper, we discuss the case of 68-year-old man who presented repeated comitial. A cerebral Magnetic Resonance Imaging (MRI) showed cerebral venous thrombosis. The only biological abnormality highlighted was high level of monoclonal gammaglobulin. The coexistence of cerebral venous thrombosis and the monoclonal gammopathy of undetermined significance were fortuitous without causality links. French Abstract La thrombose veineuse cérébrale est rarement assoc

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2

Panda, Manasi. "Rabies-Monoclonal Antibody - A Perspective." Journal of Communicable Diseases 54, no. 03 (2022): 22–26. http://dx.doi.org/10.24321/0019.5138.202285.

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Rabies is an acute viral zoonotic disease that affects the central nervous system (CNS) of all warm-blooded animals, including mammals. Research studies and experience from across the world have demonstrated that appropriate administration of a combination of (a) local wound treatment, (b) anti-rabies vaccination and (c) passive immunization have proved to be quite effective in preventing the occurrence of rabies. As far as passive immunization is concerned, polyclonal plasma-derived rabies immunoglobulins (RIG) pose a number of limitations with scarce supply, high cost, etc. amongst many othe

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3

Bauvois, Adeline, Mélusine Larivière, Hervé Watier, and François Maillot. "Actualités des anticorps monoclonaux dans les maladies monogéniques aujourd’hui." médecine/sciences 35, no. 12 (2019): 1026–28. http://dx.doi.org/10.1051/medsci/2019203.

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Les maladies monogéniques sont des maladies génétiques rares mais très nombreuses, avec une sévérité variable. Les premières utilisations des anticorps monoclonaux dans ces maladies remontent aux années 2000 et de nombreux essais sont désormais en cours. Les anticorps monoclonaux anti-(interleukine)IL-1β ont profondément transformé la prise en charge des maladies auto-inflammatoires en modulant la composante inflammatoire et en diminuant le risque d’amylose secondaire ; les anticorps monoclonaux anti-TNF-α et anti-IL-6 sont également prescrits dans ces maladies. Dans le syndrome hémolytique et

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4

Fujita, T., T. Kamato, and N. Tamura. "Characterization of functional properties of C4-binding protein by monoclonal antibodies." Journal of Immunology 134, no. 5 (1985): 3320–24. http://dx.doi.org/10.4049/jimmunol.134.5.3320.

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Abstract We prepared mouse monoclonal antibodies to human C4-binding protein (C4-bp) by fusing spleen cells from mice immunized with purified C4-bp to the mouse myeloma line P3U1. Of four monoclonal antibodies that reacted with intact C4-bp, two were specific for a 48K fragment, one of the chymotryptic cleavage products of C4-bp, and one was specific for another fragment (160K). The fourth monoclonal antibody did not react with either fragment. One of the monoclonals that reacted with the 48K fragment blocked the binding of C4-bp to cell-bound C4b. This monoclonal antibody (TK3) also inhibited

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5

Velez, D., J. D. Macmillan, and L. Miller. "Production and use of monoclonal antibodies for identification of Bradyrhizobium japonicum strains." Canadian Journal of Microbiology 34, no. 1 (1988): 88–92. http://dx.doi.org/10.1139/m88-018.

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Thirteen murine hybridomas capable of producing monoclonal antibodies to somatic antigens on Bradyrhizobium japonicum were developed and an indirect enzyme-linked immunosorbent assay was used to test reactivity of the antibodies against 20 strains of B. japonicum. Although polyclonal antisera from mice immunized with strains of B. japonicum reacted with bacterial cells of all 20 strains, individual monoclonals were more specific. Some antibodies reacted with as few as 2 and one with as many as 11 strains. On the basis of reactivity with the set of 13 monoclonal antibodies, the 20 strains of B.

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6

Hanna, R. E. B., A. G. Trudgett, and A. Anderson. "Fasciola hepatica: development of monoclonal antibodies against somatic antigens and their characterization by ultrastructural localization of antibody binding." Journal of Helminthology 62, no. 1 (1988): 15–28. http://dx.doi.org/10.1017/s0022149x00011147.

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ABSTRACTA series of monoclonal antibodies was prepared against tegumental and internal antigens ofFasciola hepaticaby immunizing mice with whole adult-fluke homogenates prior to harvesting the splenic lymphocytes for fusion. Preliminary screening by the Indirect Fluorescent Antibody technique indicated the occurrence of discrete groups of monoclonals differing from one another in tissue-specificity but within which IFA labelling patterns were fairly consistent. Representative hybridomas for 5 of these groups were stabilized and used to produce ascites fluid in mice. By application of an immuno

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7

Lubkin, Margaret, Matthew Shallice, Julie Nyhus, Louis Leong, and Birte Aggeler. "Recombinant Rabbit Monoclonal Antibodies to Study Apoptosis and Apoptotic Pathways (132.4)." Journal of Immunology 184, no. 1_Supplement (2010): 132.4. http://dx.doi.org/10.4049/jimmunol.184.supp.132.4.

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Abstract Flow cytometry a tool for studying apoptosis and apoptotic pathways. Using monoclonal antibodies for flow cytometry leads to high specificity for the detection of the target epitope of interest, limiting the use of flow cytometry to available mouse monoclonal antibodies. Here we present high quality recombinant rabbit monoclonal antibodies that do not rely on hybridoma cell lines, but are made with a proprietary recombinant technology to obtain cloned antibodies. These rabbit monoclonals were compared to other available antibodies to demonstrate high specificity and affinity to their

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8

Campbell, AM, P. Whitford, and RE Leake. "Human monoclonal antibodies and monoclonal antibody multispecificity." British Journal of Cancer 56, no. 6 (1987): 709–13. http://dx.doi.org/10.1038/bjc.1987.275.

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9

Renu, Mariam Thomas. "Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition: Report of Two Cases and Review of Literature." Archives of Renal Diseases and Management 2, no. 1 (2016): 037–39. https://doi.org/10.17352/2455-5495.000016.

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Here we report two cases of proliferative glomerulonephritis with monoclonal IgG deposits, a form of renal involvement by monoclonal gammopathy that mimics immune complex glomerulonephritis. Case 1 presented with incidental proteinuria and a renal biopsy showed mesangioproliferative glomerulonephritis with monoclonal IgG kappa deposits on immunofluorescence examination. He remains stable after one year follow up. Case 2 presented with rapidly progressive renal failure and renal biopsy showed rescentic membranoproliferative glomerulonephritis with monoclonal IgG kappa deposits on immunofluoresc

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10

Gyotoku, Y., M. Abdelmoula, F. Spertini, S. Izui, and P. H. Lambert. "Cryoglobulinemia induced by monoclonal immunoglobulin G rheumatoid factors derived from autoimmune MRL/MpJ-lpr/lpr mice." Journal of Immunology 138, no. 11 (1987): 3785–92. http://dx.doi.org/10.4049/jimmunol.138.11.3785.

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Abstract A MRL strain bearing the autosomal recessive mutant gene, lpr (lymphoproliferation), spontaneously develops, in addition to a lupus-like syndrome, unique serological and pathological manifestations. Production of high titers of IgG rheumatoid factors (RF) may be related to the formation of extremely large amounts of cryoglobulins and the development of tissue lesions such as necrotizing polyarteritis, arthritis, and glomerulonephritis. To analyze more directly the relationship of IgG RF to the development of cryoglobulins and tissue injuries, we have established four monoclonal IgG RF

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11

Zonneveld, Anton-Jan van, Harry Veerman, Just P. J. Brakenhoff, Lucien A. Aarden, Jean-Francois Cajot, and Hans Pannekoek. "Mapping of Epitopes on Human Tissue-Type Plasminogen Activator with Recombinant Deletion Mutant Proteins." Thrombosis and Haemostasis 57, no. 01 (1987): 082–86. http://dx.doi.org/10.1055/s-0038-1651067.

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SummaryAn antigen assay based on a monoclonal antibody directed against the light chain of tissue-type plasminogen activator (t-PA) was developed to quantify seven recombinant (r) t-PA deletion mutant proteins. These recombinant proteins were then employed to map different epitopes on t-PA which interact with a panel of twenty-three monoclonal anti-t-PA antibodies. Twenty were directed against domains on the heavy chain, two against the “finger” domain, three against the “epidermal growth factor-like” domain, five against the kringle 1 domain, and ten against the kringle 2 domain. Only three m

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12

Streicher, H. Z., F. Cuttitta, G. K. Buckenmeyer, H. Kawamura, J. Minna, and J. A. Berzofsky. "Mapping the idiotopes of a monoclonal anti-myoglobin antibody with syngeneic monoclonal anti-idiotypic antibodies: detection of a common idiotope." Journal of Immunology 136, no. 3 (1986): 1007–14. http://dx.doi.org/10.4049/jimmunol.136.3.1007.

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Abstract A panel of syngeneic monoclonal anti-idiotypic antibodies was prepared by immunizing A.SW mice with keyhole limpet hemocyanin-coupled A.SW monoclonal anti-myoglobin (HAL 19, IgG1) and screening the cloned hybridomas for production of IgG2 binding to idiotype but not to certain other anti-myoglobin antibodies of the same subclass in an ELISA. With these antibodies, we identified three nonoverlapping idiotopes, based on three clusters of monoclonal anti-idiotopes that mutually inhibit within each cluster, but not between clusters (Cluster I: S2, S6, S8; Cluster II: S5, S7; Cluster III:

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13

Sellwood, Jane, and Lynn Smith. "Rapid Detection of Poliovirus from Waters Using Monoclonal Antibodies." Water Science and Technology 21, no. 3 (1989): 299–301. http://dx.doi.org/10.2166/wst.1989.0123.

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Poliovirus is present in many types of water in the environment. A rapid detection method for the presence of Poliovirus could be relevant to water management. Virus components are present in cell culture from 6-18 hours after infection. The indirect immunofluorescent staining technique can be used to detect the components. Monoclonal antibodies may provide specific and sensitive reagents for this test. Two of over 50 mouse monoclonal antibodies screened were able to recognise and attach to Poliovirus 3 infected cells. The time at which fluorescence was detected was dependent on the initial vi

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14

Rieger, Paula Trahan. "Monoclonal Antibodies." American Journal of Nursing 87, no. 4 (1987): 469. http://dx.doi.org/10.2307/3470440.

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15

Kosmas, C., H. Kalofonos, and A. A. Epenetos. "Monoclonal Antibodies." Drugs 38, no. 5 (1989): 645–57. http://dx.doi.org/10.2165/00003495-198938050-00001.

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16

&NA;. "Monoclonal antibodies." Reactions Weekly &NA;, no. 1293 (2010): 36. http://dx.doi.org/10.2165/00128415-201012930-00100.

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17

&NA;. "Monoclonal Antibodies." Journal of Pediatric Hematology/Oncology 25, no. 4 (2003): S5—S6. http://dx.doi.org/10.1097/00043426-200304000-00025.

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18

&NA;. "Monoclonal Antibodies." Journal of Pediatric Hematology/Oncology 25, no. 4 (2003): S17—S18. http://dx.doi.org/10.1097/00043426-200304000-00036.

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19

Anderson, Philip O. "Monoclonal Antibodies." Breastfeeding Medicine 11, no. 3 (2016): 100–101. http://dx.doi.org/10.1089/bfm.2016.0026.

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20

Nowak, Thomas P. "Monoclonal Antibodies." American Journal of Clinical Oncology 10, no. 4 (1987): 278–80. http://dx.doi.org/10.1097/00000421-198708000-00002.

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21

Aksöz, Zekeriya. "MONOCLONAL ANTIBODIES." Hematology, Transfusion and Cell Therapy 46 (December 2024): S14. https://doi.org/10.1016/j.htct.2024.11.107.

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22

Bourne, Debra. "Monoclonal future?" Companion Animal 22, no. 10 (2017): 561. http://dx.doi.org/10.12968/coan.2017.22.10.561.

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23

Ghobrial, Rafik M., Ronald W. Busuttil, and Jerzy W. Kupiec-Weglinski. "Monoclonal antibodies." Current Opinion in Organ Transplantation 2, no. 1 (1997): 82–88. http://dx.doi.org/10.1097/00075200-199710000-00015.

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24

Rosen, Steven T., Elyse A. Lambiase, Yixing Ma, James A. Radosevich, and Alan L. Epstein. "Monoclonal antibodies." Postgraduate Medicine 77, no. 4 (1985): 129–34. http://dx.doi.org/10.1080/00325481.1985.11698922.

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25

Rabin, Brace S. "Monoclonal antibodies." Postgraduate Medicine 79, no. 1 (1986): 293–303. http://dx.doi.org/10.1080/00325481.1986.11699254.

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26

La Pine, Timothy R., and Harry R. Hill. "Monoclonal antibodies." Seminars in Pediatric Infectious Diseases 12, no. 1 (2001): 64–70. http://dx.doi.org/10.1053/spid.2001.19241.

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27

Mulshine, James. "Monoclonal Antibodies." Chest 89, no. 4 (1986): 355S. http://dx.doi.org/10.1378/chest.89.4_supplement.355s.

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28

Kemshead, J. "Monoclonal evolution." Trends in Biotechnology 15, no. 5 (1997): 195. http://dx.doi.org/10.1016/s0167-7799(97)82756-4.

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29

Borek, F. "Monoclonal antibodies." Journal of Immunological Methods 77, no. 1 (1985): 175. http://dx.doi.org/10.1016/0022-1759(85)90197-8.

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30

Howland, J. L. "Monoclonal antibodies." Biochemical Education 23, no. 4 (1995): 223. http://dx.doi.org/10.1016/0307-4412(95)90177-9.

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31

Carter, Philip B., Kim Holly Beegle, and Douglas H. Gebhard. "Monoclonal Antibodies." Veterinary Clinics of North America: Small Animal Practice 16, no. 6 (1986): 1171–79. http://dx.doi.org/10.1016/s0195-5616(86)50135-2.

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32

Cowden, Jessica, and Sarah K. Parker. "Monoclonal Antibodies." Pediatric Infectious Disease Journal 25, no. 6 (2006): 553–55. http://dx.doi.org/10.1097/01.inf.0000223443.80696.5b.

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33

Drakeman, Donald L., and Paul K. Wallace. "Monoclonal antibodies." Emerging Drugs 4, no. 1 (1999): 355–65. http://dx.doi.org/10.1517/14728214.4.1.355.

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34

Buchsbaum, Donald J. "Monoclonal antibodies." International Journal of Radiation Oncology*Biology*Physics 17 (January 1989): 84–85. http://dx.doi.org/10.1016/0360-3016(89)90573-7.

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35

Melamed, M. D., and C. E. Bradley. "Monoclonal antibodies." Current Opinion in Immunology 1, no. 5 (1989): 929–36. http://dx.doi.org/10.1016/0952-7915(89)90075-7.

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36

Koch, C., and J. Bennedsen. "Monoclonal antibodies." Current Opinion in Immunology 2, no. 3 (1990): 385–91. http://dx.doi.org/10.1016/0952-7915(89)90146-5.

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37

Chatenoud, L. "Monoclonal antibodies." Current Opinion in Immunology 2, no. 2 (1989): 246–48. http://dx.doi.org/10.1016/0952-7915(89)90195-7.

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38

Buchsbaum, Donald J. "Monoclonal antibodies." International Journal of Radiation Oncology*Biology*Physics 19 (January 1990): 92. http://dx.doi.org/10.1016/0360-3016(90)90591-7.

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39

Buchsbaum, Donald J. "Monoclonal antibodies." International Journal of Radiation Oncology*Biology*Physics 21 (January 1991): 82. http://dx.doi.org/10.1016/0360-3016(91)90373-c.

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40

Stephenson, J. "Monoclonal Milestone." JAMA: The Journal of the American Medical Association 285, no. 10 (2001): 1283—b—1283. http://dx.doi.org/10.1001/jama.285.10.1283-b.

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41

Stephenson, Joan. "Monoclonal Milestone." JAMA 285, no. 10 (2001): 1283. http://dx.doi.org/10.1001/jama.285.10.1283-jwm10002-3-1.

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42

Geskin, Larisa J. "Monoclonal Antibodies." Dermatologic Clinics 33, no. 4 (2015): 777–86. http://dx.doi.org/10.1016/j.det.2015.05.015.

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43

Napier, R. M., L. C. Fowke, C. Hawes, M. Lewis, and H. R. Pelham. "Immunological evidence that plants use both HDEL and KDEL for targeting proteins to the endoplasmic reticulum." Journal of Cell Science 102, no. 2 (1992): 261–71. http://dx.doi.org/10.1242/jcs.102.2.261.

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The epitopes of two monoclonal antibodies raised to a putative auxin receptor have been mapped. Carboxy-peptidase A digestion of the antigen, auxin-binding protein (ABP) purified from maize, completely abolished binding of antibody MAC 256 and impaired binding of MAC 259, suggesting that they both recognise C-terminal epitopes. Published sequences of ABP showed that the C terminus was KDEL, a tetrapeptide used for targeting proteins to the ER in animal cells. We have used this short homology to confirm that the two monoclonals recognise C-terminal KDEL, showing that animal KDEL proteins and sy

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44

Chamat, S., J. Hoebeke, L. Emorine, J. G. Guillet, and A. D. Strosberg. "The immune response towards beta-adrenergic ligands and their receptors. VI. Idiotypy of monoclonal anti-alprenolol antibodies." Journal of Immunology 136, no. 10 (1986): 3805–11. http://dx.doi.org/10.4049/jimmunol.136.10.3805.

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Abstract Four murine monoclonal antibodies specific for alprenolol, a synthetic beta-adrenergic ligand, with different binding properties towards alprenolol and other beta-adrenergic antagonists and agonists (as described in a previous report) were used to induce anti-idiotypic responses in rabbits and mice. Three of the rabbit anti-idiotypes inhibited, and one increased the binding of tritiated dihydroalprenolol to the Ab1 against which they were induced. The syngeneic mouse anti-idiotypes all had an inhibitory effect on the ligand binding to their corresponding Ab1. Cross-reactivity tests of

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45

Tam, Christina, Luisa Cheng, Xiaohua He, Paul Merrill, David Hodge, and Larry Stanker. "A Monoclonal–Monoclonal Antibody Based Capture ELISA for Abrin." Toxins 9, no. 10 (2017): 328. http://dx.doi.org/10.3390/toxins9100328.

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46

"Monoclonal Antibody TfR Monoclonal Antibody." Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 36, no. 1 (2017): 35. http://dx.doi.org/10.1089/mab.2017.0004.

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47

Howland Alvarez, Ivon, Yolanda Cruz Gómez, and Jorge Grisaldo Zambrano. "Daño renal asociado con componentes monoclonales débiles en pacientes cubanos con gammapatía monoclonal." Revista Mexicana de Urología 78, no. 4 (2018). http://dx.doi.org/10.48193/rmu.v78i4.86.

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OBJETIVO: Analizar la relación entre las bandas monoclonales detectadas en la electroforesis de proteínas séricas y el daño renal. MATERIALES Y MÉTODOS: Estudio observacional, descriptivo y retrospectivo efectuado a partir de la revisión de los resultados de electroforesis de proteínas efectuado en el Laboratorio de Diagnóstico Clínico del Centro de Investigaciones Médico-Quirúrgicas de La Habana, Cuba, entre enero de 2010 y diciembre de 2016. Criterios de inclusión: pacientes con componente monoclonal detectado en la electroforesis y confirmado por inmunofijación, y pacientes sin componente m

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48

Howland Alvarez, Ivon, Yolanda Cruz Gómez, and Jorge Grisaldo Zambrano. "Daño renal asociado con componentes monoclonales débiles en pacientes cubanos con gammapatía monoclonal." Revista Mexicana de Urología 78, no. 4 (2018). http://dx.doi.org/10.48193/revistamexicanadeurologa.v78i4.86.

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OBJETIVO: Analizar la relación entre las bandas monoclonales detectadas en la electroforesis de proteínas séricas y el daño renal. MATERIALES Y MÉTODOS: Estudio observacional, descriptivo y retrospectivo efectuado a partir de la revisión de los resultados de electroforesis de proteínas efectuado en el Laboratorio de Diagnóstico Clínico del Centro de Investigaciones Médico-Quirúrgicas de La Habana, Cuba, entre enero de 2010 y diciembre de 2016. Criterios de inclusión: pacientes con componente monoclonal detectado en la electroforesis y confirmado por inmunofijación, y pacientes sin componente m

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49

Beirão, Bárbara, Mariana Freitas, Natália Silva, Patrícia Ferraz, Catarina Prata, and Teresa Morgado. "Glomerulonefrite C3 associada à gamopatia monoclonal de significância renal: um desafio diagnóstico e terapêutico." Brazilian Journal of Nephrology 47, no. 2 (2025). https://doi.org/10.1590/2175-8239-jbn-2024-0106pt.

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Resumo As glomerulopatias C3 constituem um grupo heterogêneo de glomerulopatias caracterizadas por desregulação da via alternativa do complemento. Embora a fisiopatologia não esteja completamente esclarecida, há um reconhecimento crescente da associação entre essa patologia e gamopatias monoclonais, especialmente em indivíduos mais velhos. Ainda há alguma incerteza em relação ao melhor tratamento para doentes com glomerulopatia C3 associada a gamopatia monoclonal. No entanto, evidência recente sugere que tratamentos dirigidos ao clone monoclonal estão associados a melhores desfechos renais em

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50

Xu, Xiaobin. "C-termini Analysis of Monoclonal Antibody Fragmentation." Open Access Journal of Pharmaceutical Research 1, no. 1 (2017). http://dx.doi.org/10.23880/oajpr-16000102.

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