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1

Bhambra, Amarbalita. The regulatory protein of methane monooxygenase. typescript, 1996.

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2

Arinç, Emel, John B. Schenkman, and Ernest Hodgson, eds. Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-7284-4.

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3

Martin, Howard. Molecular genetics of methane monooxygenase in methylosinus trichosporium OB3b. typescript, 1994.

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4

Callaghan, Anastasia J. The regulatory protein and component interactions of soluble methane monooxygenase. typescript, 2000.

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5

Hrycay, Eugene G., and Stelvio M. Bandiera, eds. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16009-2.

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6

Lloyd, John S. Heterologous expression and site-directed mutagenesis of soluable methane monooxygenase. typescript, 1997.

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7

Gallagher, Stephen C. Structural and mechanistic studies of alkene monooxygenase from Nocardia corallina B-276. typescript, 1997.

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8

Finch, Ruth. The molecular genetics and regulation of methane monooxygenase in Methylosinus trichosporium OB3b. typescript, 1997.

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9

Jiang, Yan. Studies of the hydroxylase component of soluble methane monooxygenase from Methylococcus capsulatus (Bath). typescript, 1993.

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10

Pilkington, S. J. The soluble methane monooxygenase and ammonia oxidation in the obligate methanotroph "Methylosinus trichosporium (OB3b)". typescript, 1986.

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11

NATO Advanced Study Institute on Molecular Aspects of Drug Metabolizing Enzymes (1993 Kuşadası, Turkey). Molecular aspects of oxidative drug metabolizing enzymes: Their significance in environmental toxicology, chemical carcinogenesis, and health. Springer-Verlag,in cooperation with NATO Scientific Affairs Division, 1995.

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12

Snowberger, Gray Elisabeth. Sexual patterns of monooxygenase function in the liver of marine teleosts and the regulation of activity by estradiol. Woods Hole Oceanographic Institution, 1988.

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13

NATO Advanced Study Institute on Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds (1989 Çeşme, Turkey). Molecular aspects of monooxgenases and bioactivation of toxic compounds. Plenum Press, 1991.

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14

Parker, James N., and Philip M. Parker. Trimethylaminuria: A bibliography and dictionary for physicians, patients, and genome researchers [to Internet references]. ICON Health Publications, 2007.

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15

Fears, Robin. Cholesterol 7A-Hydroxylase (7a-Monooxygenase). Crc Pr I Llc, 1986.

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16

Yueh, Mei-Fei. Developmental regulation of flavin-containing monooxygenase (FMO) form 1 and form 2 mRNA in fetal and neonatal rabbit. 1994.

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17

Su, Shelley A. Larsen. Developmental and dietary regulation of flavin-containing monooxygenase. 1998.

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18

Lee, Min-young. Flavin-containing monooxygenase, tissue specific regulation in rabbit. 1991.

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19

Lee, Min-young. Flavin-containing monooxygenase, tissue specific regulation in rabbit. 1991.

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20

Arinç, Emel. Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds. Springer, 2012.

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21

NATO Advanced Study Institute on Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds (1989 Çeşme, Turkey). Molecular aspects of monooxygenases and bioactivation of toxic compounds. Plenum Press, 1991.

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22

Hamamura, Natsuko. Chloroform cometabolism by butane-grown bacteria: Diversity in butane monooxygenases. 1997.

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23

Hrycay, Eugene G., and Stelvio M. Bandiera. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Springer, 2015.

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24

Yang, Yea-Huey. Cloning, heterologus expression, and characterization of the cytochrome P450 monooxygenases in rainbow trout (Oncorhynchus mykiss). 1997.

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25

Juliette, Lisa Yvonne. In vivo and in vitro characterization of ammonia monooxygenase in Nitrosomonas europaea. 1995.

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26

Yueh, Mei-Fei. Identification and characterization of flavin-containing monooxygenase isoform 2 (FMO2) in Rhesus monkey and examination of a human FMO2 polymorphism. 1999.

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27

Huijzer, Jeannette Clazina. Bioactivation of 3-methylindole and the involvement of cytochrome P-450 monooxygenases. 1987.

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28

Keener, William Kelvin. Interactions of ammonia monooxygenase in Nitrosomonas europaea with hydrocarbons and subtituted hydrocarbons. 1995.

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29

(Editor), Emel Arinç, John B. Schenkman (Editor), and Ernest Hodgson (Editor), eds. Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds (Nato Science Series: A:). Springer, 1991.

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30

Emel, Arinç, Schenkman John B, and Hodgson Ernest 1932-, eds. Molecular and applied aspects of oxidative drug metabolizing enzymes. Plenum Press, 1999.

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31

Cascorbi, Ingolf. Polymorphic cytochrome P450 2D6 as the responsible enzyme of activation. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0079.

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The landmark paper discussed in this chapter is ‘Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)’, published by Dayer et al. in 1988. Codeine is an old but frequently prescribed drug used for the treatment of mild-to-moderate pain. However, its use is nowadays restricted after observations of partly fatal respiratory repression in children. Codeine itself exhibits no analgesic effect, but is partly activated by O-demethylation to morphine by cytochrome P450 2D6 (CYP2D6). T
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32

Levine, Steven L. Influence of environmental factors, physiological factors and benzo[a]pyrene exposure on the hepatic monooxygenase system of gizzard shad (Dorosoma cepedianum). 1993.

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33

1942-, Schmid Rolf, and Urlacher Vlada B, eds. Modern biooxidation: Enzymes, reactions, and applications. Wiley-VCH, 2007.

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34

Modern biooxidation: Enzymes, reactions and applications. Wiley-VCH, 2008.

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35

Schenkman, John B. Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health (Nato a S I Series Series H, Cell Biology). Springer-Verlag Telos, 1995.

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36

Emel, Arinç, Schenkman John B, Hodgson Ernest 1932-, and NATO Advanced Study Institute on Molecular Aspects of Drug Metabolizing Enzymes (1993 : Kus̜adası, Turkey), eds. Molecular aspects of oxidative drug metabolizing enzymes: Their significance in environmental toxicology, chemical carcinogenesis, and health. Springer-Verlag, 1995.

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