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Journal articles on the topic 'Montelukast sodium'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Graul, A., L. Martín, and J. Castañer. "Montelukast Sodium." Drugs of the Future 22, no. 10 (1997): 1103. http://dx.doi.org/10.1358/dof.1997.022.10.425873.

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2

Patil, T. N., S. D. Firke, S. B. Bari, N. S. Joshi, and P. S. Bafna. "SIMULTANEOUS ESTIMATION OF EBASTINE AND MONTELUKAST SODIUM IN TABLET DOSAGE FORM BY UV-SPECTROPHOTOMETRY AND FIRST ORDER DERIVATIVE." INDIAN DRUGS 50, no. 10 (2013): 47–52. http://dx.doi.org/10.53879/id.50.10.p0047.

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A simple, precise, accurate and reproducible spectrophotometric method has been developed for simultaneous estimation of ebastine and montelukast sodium by employing first order derivative zero crossing method in methanol and water. The first order derivative absorption at 234 nm (zero cross point of ebastine) was used for quantification of montelukast sodium and 281.60 nm (zero cross point of montelukast sodium) for quantification of ebastine. The linearity was established over the concentration range of 5-25 μg/mL for both ebastine and montelukast sodium with correlation coefficient r2 0.997

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3

Pinkal, Patel, A. Panchal Zinal, Patel Sweta, and AdarshJha. "SPECTROPHOTOMETRIC ABSORPTION CORRECTION FOR THE METHOD SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND BILASTINE IN TABLET DOSAGE FORM." International Journal of Education & Applied Sciences Research 9, no. 2 (2022): 20–28. https://doi.org/10.5281/zenodo.7075239.

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<em>For the simultaneous determination of Montelukast sodium and Bilastine in combination utilising methanol as solvent, a new, simple, effective, explicit, definite, and sensitive UV spectrophotometric absorption correction method has been devised. The absorbance correction approach is based on the additive property. 252 nm and 344 nm were chosen as the wavelengths for the absorption correction technique. While Bilastine exhibited negligible absorbance at 344 nm, Montelukast sodium displayed modest absorbance. At 252 nm, both medications produced absorption. Utilizing measurements of absorban

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4

Bhanushali, Vidhi, Celina Nazareth, and Rakshanda S. Khorjuwenkar. "NOVEL UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND OLOPATADINE HYDROCHLORIDE USING ABSORBANCE CORRECTION PRINCIPLE." INDIAN DRUGS 61, no. 02 (2024): 57–61. http://dx.doi.org/10.53879/id.61.02.13426.

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A simple, accurate and economical UV spectroscopic method has been developed for the simultaneous estimation of olopatadine hydrochloride and montelukast sodium. The developed method is based on the determination of the two drugs using UV absorbance correction principle. The wavelengths chosen for analysis were 352 nm for montelukast sodium (as absorbance due to the other drug was nil at this wavelength) and 298.5 nm for olopatadine hydrochloride (corrected for absorbance due to montelukast sodium) with water as diluent. The Beer-Lambert’s range for the two drugs was found to be 2-100 μg mL-1

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5

Gosavi, Seema, Aditi Kulkarni, Sarita Pawar, et al. "Comparative analysis of analytical method development and its validation for the simultaneous estimation of Bilastine and Montelukast Sodium in bulk and its tablet formulation by planar chromatography." International Journal of Experimental Research and Review 32 (August 30, 2023): 387–97. http://dx.doi.org/10.52756/ijerr.2023.v32.034.

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The development and validation of analytical methods are crucial in guaranteeing the precision, dependability, and excellence of pharmaceutical analysis. This research investigates the field of pharmaceutical chemistry by doing a comparative examination of analytical techniques for the simultaneous determination of Bilastine and Montelukast Sodium in both bulk and tablet forms. The selected method for this analysis is planar chromatography. The simplicity, specificity, precision, and accuracy of a high-performance liquid chromatography (HPTLC) approach were investigated for their use in the si

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Adnan, Manar, RoaaA.Nief, Shaimaa Nazar Abd-Al Hameed, and Haneen Abdulhadi Kharaba. "Preparation and In-Vitro Evaluation of Floating Oral In- Situ Gel of Montelukast Sodium (Conference Paper) #." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 31, Suppl. (2023): 162–67. http://dx.doi.org/10.31351/vol31isssuppl.pp162-167.

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There were several goals in this study, the most important of which was to create an oral liquid preparation (Ion sensitive floating oral in situ gel system for sustained delivery of Montelukast Sodium for pediatric patients) that would make administration easier, provide the correct therapeutic dose, and allow the drug to be released more slowly into the digestive tract (GIT) for better control. Montelukast Sodium in situ gels at different concentration (w/v) of natural polysaccharides (Gellan gum and sodium alginate) and natural polymer (Pectin) were prepared and characterized in the t

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7

Das, Joysree, Md Sohorab Uddin, and Md Shahadat Hossain. "Exploring Montelukast Sodium and Calcium Chloride Interactions: A Comparative Study at Physiological and Gastric pH Levels." European Journal of Theoretical and Applied Sciences 2, no. 3 (2024): 840–50. http://dx.doi.org/10.59324/ejtas.2024.2(3).66.

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Montelukast, a leukotriene receptor antagonist (LTRA) is used to prevent an asthmatic attack, shortness of breath and wheezing. As intravenous therapy, Calcium chloride (fused) is used to treat hypocalcemia. Using spectrophotometry, an in vitro study of the interaction between Montelukast sodium and Calcium chloride (fused) was conducted at pH 7.4 and pH 2.4 in aqueous systems at 37 ± 0.5 °C. A reverse V-shaped curve was found from the Job’s plot indicating a strong kinetics between Montelukast sodium and Calcium chloride. The stability constant was obtained from Ardon’s plot for the complexat

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8

Joysree, Das, Sohorab Uddin Md, and Shahadat Hossain Md. "Exploring Montelukast Sodium and Calcium Chloride Interactions: A Comparative Study at Physiological and Gastric pH Levels." European Journal of Theoretical and Applied Sciences 2, no. 3 (2024): 840–50. https://doi.org/10.59324/ejtas.2024.2(3).66.

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Montelukast, a leukotriene receptor antagonist (LTRA) is used to prevent an asthmatic attack, shortness of breath and wheezing. As intravenous therapy, Calcium chloride (fused) is used to treat hypocalcemia. Using spectrophotometry, an <em>in vitro </em>study of the interaction between Montelukast sodium and Calcium chloride (fused) was conducted at pH 7.4 and pH 2.4 in aqueous systems at 37 ± 0.5 °C. A reverse V-shaped curve was found from the Job’s plot indicating a strong kinetics between Montelukast sodium and Calcium chloride. The stability constant was obtained from

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9

Anumolu, Panikumar Durga, Pulusu Veera Shakar, Jampana Rama Tulasi, Chaganti Soujanya, Syed Sara Afreen, and Gorja Ashok. "Concurrent Discriminative Emission Intensity Quantification of Fexofenadine hydrochloride and Montelukast Sodium." Oriental Journal Of Chemistry 38, no. 6 (2022): 1364–68. http://dx.doi.org/10.13005/ojc/380605.

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The synergistic effect of Fexofenadine Hydrochloride an anti-histamine agent and Montelukast Sodium in treating allergies by antagonizing histamine and leukotriene prompted their use as effctive fixed dosage form combination. The current research scenario is about concurrent analysis of these drugs by spectroflourimetric method with the wavelength of excitation and emission 261 nm and 287 nm for Fexofenadine Hydrochloride and 392 nm 487 nm for Montelukast Sodium.The Calibration curves were observed to be rectilinear over the concentration ranges 20-100 µg/mL for Fexofenadine Hydrochloride and

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10

Davis, Beth E., and Donald W. Cockcroft. "Effect of a Single Dose Montelukast Sodium on Methacholine Chloride PC20." Canadian Respiratory Journal 12, no. 1 (2005): 26–28. http://dx.doi.org/10.1155/2005/284930.

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BACKGROUND: It is currently recommended that leukotriene modifiers (receptor antagonists and synthesis inhibitors) be withheld for a minimum of 24 h before direct bronchoprovocation testing, but there is little evidence to support this recommendation.OBJECTIVE: To examine the effect of a single oral dose of montelukast sodium 10 mg on airway response to methacholine chloride-induced bronchoconstriction.METHODS: A double-blind, placebo-controlled, randomized crossover trial was performed in 12 subjects with asthma whose methacholine chloride concentration causing a 20% decrease in the forced ex

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11

Rahman, M. A., M. S. Hossain, M. M. Moulee, et al. "Use of bi-layer tablet technology to formulate dual-release dosage form of extended-release Montelukast and immediate-release Bilastine." Bangladesh Journal of Scientific and Industrial Research 59, no. 4 (2024): 231–48. https://doi.org/10.3329/bjsir.v59i4.77021.

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Bilayer tablets containing Montelukast sodium, a bronchodilator, and Bilastine, an antihistamine, were formulated and assessed for pharmaceutical parameters. Twelve immediate-release Bilastine formulations, seven controlled-release Montelukast sodium formulations, and fourteen bilayer formulations were prepared. Stability studies employing FTIR, TGA, and SEM validated compatibilitywith excipients. Bilastine granules demonstrated bulk and tapped densities ranging from 0.33 to 0.38 g/mL and 0.429 to 0.488 g/mL, respectively. Carr’s index, Hausner ratio, and angle of repose suggested favorable fl

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12

Raja, T., and A. L. Rao. "DEVELOPMENT AND VALIDATION OF NEW HPT LC METHOD FOR SIMULTANEOUS ESTIMATION OF RUPATIDINE FUMARATE AND MONTELUKAST SODIUM IN TABLET DOSAGE FORM." INDIAN DRUGS 50, no. 06 (2013): 29–35. http://dx.doi.org/10.53879/id.50.06.p0029.

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A new simple high performance thin layer chromatographic method for simultaneous determination of rupatidine fumarate and montelukast sodium in bulk and tablet dosage form was investigated. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of acetone:methanol:toluene (2:3:5, V/V/V). Densitometric evaluation of the separated zones was performed at 286 nm and the method was validated. The Rf values and drug content of rupatidine fumarate and montelukast sodium were 0.57±0.02, 0.68±0.

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13

Pinkal, Patel, A. Panchal Zinal, Sweta Patel, and Shaikh Alamas. "SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND BILASTINE IN TABLET DOSAGE FORM BY SIMULTANEOUS EQUATION SPECTROPHOTOMETRIC METHOD." International Journal of Education & Applied Sciences Research 9, no. 2 (2022): 34–43. https://doi.org/10.5281/zenodo.7307826.

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<strong>ABSTRACT</strong> <em>A precise, exact, cost effective technique for estimating Montelukast sodium and Bilastine simultaneously in several tablet definite volume has been evolved using the concept of simultaneous equation approach. Measurements of bilastine at 282 nm and montelukast at 344 nm in methanol form the basis of the approach. According to ICH guidelines, many analytical parameters including linearity, precision, accuracy, and toughness were determined. The concentration ranges of montelukast and bilastine, which are 2-12 g/ml and 4-24 g/ml, respectively, show linearity at the

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14

Yun, Tae Han, Moon Jung Kim, Jung Gyun Lee, Kyu Ho Bang, and Kyeong Soo Kim. "Enhanced Stability and Compatibility of Montelukast and Levocetirizine in a Fixed-Dose Combination Monolayer Tablet." Pharmaceutics 16, no. 7 (2024): 963. http://dx.doi.org/10.3390/pharmaceutics16070963.

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The purpose of this study was to enhance the stability of montelukast and levocetirizine for the development of a fixed-dose combination (FDC) monolayer tablet. To evaluate the compatibility of montelukast and levocetirizine, a mixture of the two drugs was prepared, and changes in the appearance characteristics and impurity content were observed in a dry oven at 60 °C. Excipients that contributed minimally to impurity increases were selected to minimize drug interactions. Mannitol, microcrystalline cellulose, croscarmellose sodium, hypromellose, and sodium citrate were chosen as excipients, an

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15

Thapa, Shankar, Bipindra Pandey Pandey, and Mahalakshami Suresha Biradar. "Analytical Method Development and Validation of Simultaneous Estimation of Pure and Tablet Dosage Form by RP-HPLC." Journal of Nepal Chemical Society 44, no. 2 (2024): 13–22. http://dx.doi.org/10.3126/jncs.v44i2.68298.

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The aim of this analytical research is to establish and validate the RP-HPLC (Reverse Phase High Performance Liquid Chromatography) method for concurrently quantifying Montelukast Sodium, Fexofenadine Hydrochloride, and Acebrophylline in a pharmaceutical formulation. The method utilized Rosagiline mesylate as an internal standard, employing a Shim-Pack Solar C18 Column (4.6 x 150 mm, 5 µm) as the stationary phase and a mobile phase composed of acetonitrile, methanol, and 10 mM Na2HPO4 buffer (50:30:20 % v/v/v, pH 5.5). The flow rate was maintained at 1.0 mL/min, and detection occurred at 210 n

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16

&NA;. "Montelukast Sodium for Young Children." Nurse Practitioner 30, no. 11 (2005): 76. http://dx.doi.org/10.1097/00006205-200511000-00023.

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17

MORICE, A. H. "Montelukast sodium in cystic fibrosis." Thorax 56, no. 3 (2001): 244a—244. http://dx.doi.org/10.1136/thorax.56.3.244a.

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18

Sun, Zhongyi, Hongyan Lu, Bo Yang, et al. "Montelukast Sodium to Prevent and Treat Bronchopulmonary Dysplasia in Very Preterm Infants: A Quasi-Randomized Controlled Trial." Journal of Clinical Medicine 12, no. 24 (2023): 7745. http://dx.doi.org/10.3390/jcm12247745.

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Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in preterm infants and lacks effective methods for prevention and treatment. The aim of this study is to explore the efficacy and safety of montelukast in preventing or treating BPD in preterm infants. The preterm infants with BPD risk factors were divided randomly into a montelukast group and a control group. In the montelukast group, preterm infants were given 1 mg/kg of montelukast sodium daily. There was no placebo in the control group. There was no significant difference in the incidence of moderate or severe BPD bet

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19

Jones, T. R., M. Labelle, M. Belley, et al. "Pharmacology of montelukast sodium (Singulair™), a potent and selective leukotriene D4 receptor antagonist." Canadian Journal of Physiology and Pharmacology 73, no. 2 (1995): 191–201. http://dx.doi.org/10.1139/y95-028.

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Montelukast sodium (Singulair™), also known as MK-0476 (1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)(3-2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane) acetic acid sodium salt, is a potent and selective inhibitor of [3H]leukotriene D4 specific binding in guinea pig lung (Ki 0.18 ± 0.03 nM), sheep lung (Ki 4 nM), and dimethylsulfoxide-differentiated U937 cell plasma membrane preparations (Ki 0.52 ± 0.23 nM), but it was essentially inactive versus [3H]leukotriene C4 specific binding in dimethylsulfoxide-differentiated U937 cell membranes (IC50 10 μM) and [3H]leuk

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20

Sobczak, Marharyta, and Rafał Pawliczak. "Does Vitamin D Work Synergistically with Anti-Asthmatic Drugs in Airway Remodeling?" International Journal of Molecular Sciences 23, no. 21 (2022): 12798. http://dx.doi.org/10.3390/ijms232112798.

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Vitamin D is commonly known for its properties of airway remodeling inhibition. Due to this, we decided to analyze the action of calcitriol with anti-asthmatic drugs in airway remodeling. The HFL1 cell line was treated with calcitriol, beclomethasone 17-propionate, montelukast sodium, LTD4 and TGF-β in different combinations. Real-time PCR was used to analyzed the expression of ACTA2, CDH-1, Vimentin, ADAM33, MMP-9 and CysLTR1 on the mRNA level, whereas Western blot was used to analyze gene expression on the protein level. One-way analysis variants, the Kruskal-Wallis test, Student’s t-test or

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21

Joshi, Devesh Kumar, Krishna Chaitanya Veligandla, Rahul Rathod, and Bhavesh P. Kotak. "In-Vitro Comparative Study of Levocetirizine Dihydrochloride and Montelukast Sodium Release Profiles in Xyzal M Suspension and Other Marketed Syrup Formulations." Journal of Drug Delivery and Therapeutics 13, no. 8 (2023): 32–44. http://dx.doi.org/10.22270/jddt.v13i8.6164.

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Objectives: In-vitro comparative analysis of the release profile of levocetirizine dihydrochloride and montelukast sodium in Xyzal M Suspension and three commercially available syrup formulations. Method: The active components and their impurities were initially assayed in all formulations using a validated HPLC method. The enantiomeric impurities of montelukast sodium in different pH media were determined using the HPLC method specified in the United State Pharmacopoeia (USP) monograph. Additionally, dissolution studies and the soluble fractions of the components were evaluated in pH me

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Dipali, Kakade1 Shabnam khan2 Ramakant Sharma2 Jeevan Patel2 Shivani Khoware2 Rakesh Patel3. "Formulation and Evaluation of Montelukast levocetirizine Tablet." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 182–92. https://doi.org/10.5281/zenodo.10794492.

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Formulation and Evaluation of tablet containing combination of Montelukast and    Levocetirizine. The objective of present work is-To improve and increase the stability of both montelukast and Levocetirizine in combination as tablet. Enhancement of dissolution of Montelukast. To formulate and evaluate tablets of Levocetirizine and Montelukast for treating allergic rhinitis effectively. The begin with general introduction presenting overview about drugs for allergic rhinitis and combination of montelukast and Levocetirizine tablet. In the present research work, montelukast Levoce

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Répásy, Balázs, Dóra Endrei, Antal Zemplényi, István Ágoston, and Imre Boncz. "A montelukasztterápia betegterheinek változása a generikus árverseny hatására." Orvosi Hetilap 159, no. 17 (2018): 682–87. http://dx.doi.org/10.1556/650.2018.31020.

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Abstract: Introduction and aim: The aim of our study was to analyse the public price of the montelukast sodium therapy in Hungary. Method: Data derived from the nationwide pharmaceutical database of the Hungarian National Health Insurance Fund Administration. We observed the turnover and price of the medicaments containing the active substance montelukast sodium from 2007 to 2015. Accordingly, our indicators were: consumer price, DCT (daily cost of therapy), co-payment, quasi co-payment, DOT (days of treatment). Results: Due to the increasing DOT, the total amount of the public price paid by t

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24

Benedictis, F. M., S. Vaccher, and D. Benedictis. "Montelukast sodium for exercise-induced asthma." Drugs of Today 44, no. 11 (2008): 845. http://dx.doi.org/10.1358/dot.2008.44.11.1297498.

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25

Muenraya, Poowadon, Apichart Atipairin, Teerapol Srichana, Narumon Changsan, Neelam Balekar, and Somchai Sawatdee. "Development of Pharmaceutical Equivalent Montelukast Sodium Immediate-Release, Film-Coated Tablets." Science and Technology Indonesia 9, no. 1 (2024): 43–58. http://dx.doi.org/10.26554/sti.2024.9.1.43-58.

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Montelukast tablets are sold under the brand name Singulair and are used to control and prevent asthma symptoms. In this study, 10 mg film-coated montelukast tablets were developed as a generic drug in order to evaluate the pharmaceutical equivalent of the innovator’s products. The primary formulation ingredients used in all developed formulations (F1-F5) were the same as those described in the Singulair tablet package insert, except for formulations F3, F4, and F5, to which solubilizing enhancers were added to increase montelukast solubility. The core tablets were produced using the wet granu

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Samina, Alam Safila Naveed Saima Saleem Huma Dilshad Zakia Hafeez uddin Queshi Halima Moin1 Dr. Tanweer Alam. "CONCURRENT ESTIMATION OF GEMIFLOXACIN, ATORVASTATIN, GLIMEPIRIDE AND MONTELUKAST SODIUM ACTIVE PHARMACEUTICAL INGREDIENTS BY RP-HPLC TECHNIQUE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 8885–93. https://doi.org/10.5281/zenodo.2667505.

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<em>The objective of the experimental study was to developed a validated RP-HPLC analytical method for the simultaneous estimation of gemifloxacin in the presence of atorvastatinGlimepiride and montelukast sodium. The chromatographic analysis involved C18 (5 μm, 25×0.46 cm) column, mobile phase consisted of methanol : water (80:20 v/v with flow rate of 1.0 mL·min−1 and  pH 3.0 was maintained. Retention time of gemifloxacin , atorvastatin,glimipiride and montelukast was found to be 2.09, 3.5 min , 4.4 min  and 7.7 min respectively at 244 nm. The correlation

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27

Faizan, Sayeed*. "FORMULATION AND EVALUATION OF TIME DEPENDENDT RELEASE OF MONTELUKAST TABLETS BY USING MINI TABLET TECHNOLOGY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2550–62. https://doi.org/10.5281/zenodo.1219739.

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Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma, chronic asthma attacks and to relive symptoms of seasonal allergies. The main drawback of conventional Montelukast formulation is that it undergoes hepatic first pass metabolism. Thus, it shows plasma or biological half-life 2.5 to 5.5 hrs, thereby decreasing bioavailability upto 64%. The present work describes such delivery system, which will improve the biological half-life as well as bioavailability of Montelukast. This makes Montelukast a suitable candidate for incorporation in sustained-r

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Srujan, Vennela, and Pavani Sriram. "Formulation and Evaluation of Montelukast Sodium Lozenges." American Journal of PharmTech Research 9, no. 2 (2019): 112–23. http://dx.doi.org/10.46624/ajptr.2019.v9.i2.011.

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Bollikonda, Satyanarayana, Saravanan Mohanarangam, Rajender Reddy Jinna, et al. "An Enantioselective Formal Synthesis of Montelukast Sodium." Journal of Organic Chemistry 80, no. 8 (2015): 3891–901. http://dx.doi.org/10.1021/acs.joc.5b00197.

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30

Shakalisava, Yuliya, and Fiona Regan. "Determination of montelukast sodium by capillary electrophoresis." Journal of Separation Science 31, no. 6-7 (2008): 1137–43. http://dx.doi.org/10.1002/jssc.200700591.

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31

Shtrygol, S. Yu, I. G. Kapelka, M. V. Mishchenko, and O. Ya Mishchenko. "Non-obvious effects of montelukast – leukotriene receptor blocker: frigoprotective and anticonvulsant properties." Medicni perspektivi (Medical perspectives) 26, no. 2 (2021): 19–25. http://dx.doi.org/10.26641/2307-0404.2021.2.234486.

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The participation of arachidonic acid metabolism products – prostaglandins and leukotrienes – in the process of inflammation is a common pathogenetic link of cold injury and epilepsy. Montelukast is widely used for the treatment of bronchial asthma and allergic rhinitis as a leukotriene receptor blocker. However, the mechanism of action of the drug suggests a wider range of its pharmacological properties and the corresponding scope of application. This study is aimed to determine the effectiveness of montelukast as a potential frigoprotective and anticonvulsant drug. Experiments were performed

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Chu, Fangfang, Lei Liang, and Fuzhe Chen. "Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma." Allergologia et Immunopathologia 51, no. 4 (2023): 151–57. http://dx.doi.org/10.15586/aei.v51i4.897.

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Background and aim: Bronchial asthma is a prevalent type of respiratory disease that affects a large proportion of pediatric patients. The purpose of this study is to further investigate the clinical effects of budesonide combined with montelukast sodium in treating bronchial asthma. Methods: Eighty six children with bronchial asthma were equally divided into study and control groups via randomized double-blind controlled trial. The control group was treated with aerosol inhalation of budesonide combined with placebo, while the study group was treated with budesonide combined with montelukast

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33

Huang, He. "Clinical Analysis of Dispelling Wind, Eliminating Lung and Relieving Cough Combined with Western Medicine in the Treatment of Cough Variant Asthma in Children." Journal of Clinical and Nursing Research 5, no. 5 (2021): 136–41. http://dx.doi.org/10.26689/jcnr.v5i5.2583.

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Objective: This study mainly explores the clinical effect of dispelling wind, eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma. Methods: 80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups. One group was the reference group (40 cases) treated with procaterol hydrochloride tablets and montelukast sodium, and the other group was the research group (40 cases). The method of eliminating wind, eliminating lung and relieving cough

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Xu, Rui, Li Wang, Zhuan Huang, Yurong Zhang, and Lingjuan Huang. "Assessing the Effectiveness of Montelukast Sodium in Managing Pulmonary Infections in Lung Cancer Patients." Proceedings of Anticancer Research 7, no. 6 (2023): 128–35. http://dx.doi.org/10.26689/par.v7i6.5523.

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Objective: To investigate the efficacy of montelukast sodium in the treatment of lung cancer patients with pulmonary infections. Methods: A total of 330 patients diagnosed with lung cancer and pulmonary infection, who were admitted to the First Affiliated Hospital of Xi’an Medical University from 2020 to 2022, were selected as research subjects. They were randomly divided into two groups: a control group receiving conventional treatment and an observation group receiving conventional treatment combined with montelukast sodium. Each group consisted of 165 cases. The time required for clinical s

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Shtrygol, S.Yu., I.G. Kapelka, M.V. Mishchenko, and O.Ya. Mishchenko. "Non-obvious effects of montelukast – leukotriene receptor blocker: frigoprotective and anticonvulsant properties." Medicni perspektivi 26, no. 2 (2021): 19–25. https://doi.org/10.26641/2307-0404.2021.2.234486.

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The participation of arachidonic acid metabolism products – prostaglandins and leukotrienes – in the process of inflammation is a common pathogenetic link of cold injury and epilepsy. Montelukast is widely used for the treatment of bronchial asthma and allergic rhinitis as a leukotriene receptor blocker. However, the mechanism of action of the drug suggests a wider range of its pharmacological properties and the corresponding scope of application. This study is aimed to determine the effectiveness of montelukast as a potential frigoprotective and anticonvulsant drug. Experiments we

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Varshosaz, Jaleh, Shaghayegh Haghjooy Javanmard, Sahel Soghrati, and Behshid Behdadfar. "Magnetic chondroitin targeted nanoparticles for dual targeting of montelukast in prevention of in-stent restenosis." RSC Advances 6, no. 15 (2016): 12337–47. http://dx.doi.org/10.1039/c5ra20966h.

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Magnetic nanoparticles and sodium montelukast encapsulated in rosin gum nanoparticles were targeted by chondroitin sulfate coated on their surface. They showed adhesion to endothelial cells and efficiently suppressed the VCAM-1 expression.

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Omar Adnan Hashem, Semaa Hamed Ahmad, and Sabreen Shakeir Mahmood. "Determination of Montelukast Sodium by flow injection chemiluminescence." Tikrit Journal of Pure Science 23, no. 2 (2023): 88–94. http://dx.doi.org/10.25130/tjps.v23i2.656.

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This study includes determination Montelukast sodium by using flow injection chemiluminescence technique, the optimum concentrations were (150) ppm of magnesum ion, (5×10-4) M luminol, (0.001) M hydrogen peroxide, linearity of concetraction (0.1-0.001) M that give the highest luminescence intensity, and correlation cofficient was (0.9054), The relative standard deviation RSD% (2.3) and detection limit (0.0001) M and relative error (0.018) ,the percent recovery (97%).

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Ahmad, Semaa Hamed, Omar Adnan Hashem, and Sabreen Shakeir Mahmood. "Determination of Montelukast Sodium by flow injection chemiluminescence." Tikrit Journal of Pure Science 23, no. 2 (2018): 88–94. http://dx.doi.org/10.25130/tjps.23.2018.033.

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Diggikar, Susmit S., Tanaji D. Nandgude, and Sushilkumar S. Poddar. "Formulation of Modified Release Pellets of Montelukast Sodium." Research Journal of Pharmacy and Technology 11, no. 1 (2018): 31. http://dx.doi.org/10.5958/0974-360x.2018.00006.9.

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Narin, Ibrahim, Salih Sarioglan, Beril Anilanmert, and Hayati Sari. "pK a Determinations for Montelukast Sodium and Levodropropizine." Journal of Solution Chemistry 39, no. 10 (2010): 1582–88. http://dx.doi.org/10.1007/s10953-010-9604-z.

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Kassem, Alaa EldinA, MahaA Marzouk, SheerenA El-Adawy, and AyaM Dawaba. "Preparation and Evaluation of Montelukast Sodium Sublingual Films." Journal of Pharmaceutical Sciences and Pharmacology 3, no. 2 (2017): 98–106. http://dx.doi.org/10.1166/jpsp.2017.1080.

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Chauhan, Manhi, Ashutosh Sharma, Priya Sharma, and Sunil Sain. "Design, Development and Evaluation of Oral Dissolving film of Montelukast Sodium." Journal of Biomedical and Pharmaceutical Research 13, no. 3 (2024): 16–27. http://dx.doi.org/10.32553/jbpr.v13i3.1088.

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Montelukast Sodium (MS) is widely used for managing asthma and allergic rhinitis due to its leukotriene receptor antagonist properties. However, traditional oral dosage forms often lead to challenges in patient compliance and delayed onset of action. This study focuses on the design, development, and optimization of oral dissolving films (ODFs) of Montelukast Sodium, aimed at improving patient compliance and ensuring rapid drug release. Using the solvent casting method, various formulations were prepared with different concentrations of hydroxypropyl methylcellulose (HPMC), Eudragit, and Xanth

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Faruquee, Mahmud Ullah, Mostafa Mahfuzul Anwar, Kyaw Khin U, et al. "Role of Mometasone Furoate Nasal Spray Combined with Montelukast Sodium in the Treatment of Adenoids Hypertrophy in Children." Journal of Chittagong Medical College Teachers' Association 32, no. 2 (2021): 59–63. http://dx.doi.org/10.3329/jcmcta.v32i2.66481.

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Background: Adenoidectomy is currently considered the treatment of choice for children with severe symptoms caused by Adenoids Hypertrophy (AH). Non-surgical alternative treatment options are considered in less severe cases to avoid the untoward effect of surgery. This study was aimed to evaluate the efficacy and safety of Mometasone Furoate nasal spray combined with Montelukast Sodium in children with AH. Materials and methods: This trial included 118 patients aged 3 to 13 years having symptomatic AH from the OPD of Otolaryngology and Head Neck Surgery of CMCH from May 2019 to April 202

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M.Rama, Krishna *. A. Prameela Rani and V.Saikishore. "PREPARATION AND EVALUATION OF PULSATILE DRUG DELIVERY OF MONTELUKAST SODIUM." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 1855–61. https://doi.org/10.5281/zenodo.825744.

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In the present study, an effort was made to develop a novel dosage form by using a chronopharmaceutical approach for the treatment of nocturnal asthma using Montelukast sodium as a model drug. A time delayed capsule was prepared by sealing the microspheres inside the insoluble hard gelatin capsule body with erodible hydrogel plug. The microspheres were prepared by emulsion solvent evaporation technique. Optimized microsphere formulations were selected based on dissolution studies. The entire device was enteric coated, so that the variability in gastric emptying time can be overcome and a colon

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Rehman, Abid Ur, Gul Hassan, Rahman Shah, et al. "Characterization Formulation and in Vitro Assesment of Pulsatile Drug Delivery of Montelukast Sodium." Pakistan Journal of Medical and Health Sciences 16, no. 8 (2022): 584–86. http://dx.doi.org/10.53350/pjmhs22168584.

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The Montelukast pulsatile delivery system was created with the goal of delivering the drug to the colon for successful treatment of nocturnal asthma. The microspheres were sealed within the insoluble hard gelatin capsule body with an erodible hydrogel plug to create a time delayed capsule. Emulsion solvent evaporation was used to make the microspheres. Based on dissolving tests, optimised microsphere formulations were designed. The entire device was enteric coated in order to overcome the variability in gastric emptying time and achieve colon-specific delivery. The hydrogel plug (HPMC K100 and

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Rashmitha, N., T. Joseph Sunder Raj, Ch Srinivas, et al. "A Validated RP-HPLC Method for theDetermination of Impurities in Montelukast Sodium." E-Journal of Chemistry 7, no. 2 (2010): 555–63. http://dx.doi.org/10.1155/2010/156593.

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The present paper describes the development of a reverse phase chromatographic (RPLC) method for montelukast sodium in the presence of its impurities and degradation products generated from forced degradation studies. The drug substance was subjected to stress conditions of hydrolysis, oxidation, photolysis and thermal degradation. The degradation of montelukast sodium was observed under acid and oxidative environment. The drug was found to be stable in other stress conditions studied. Successful separation of the drug from the process impurities and degradation products formed under stress co

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ZAKIROVA, Bahora Islamovna, Kamola Talatovna AZIMOVA, and Shirin Kamiljonovna Khusainova. "ISSUES OF OPTIMIZATION OF THERAPY FOR RECURRENCE OF BRONCHOBSTRUCTIVE SYNDROME IN CHILDREN." Journal of biomedicine and practice 7, no. 2 (2022): 329–44. https://doi.org/10.5281/zenodo.6589560.

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The results of anamnestic, generally accepted clinical laboratory and special examination methods in 52 children with a relapsing course of bronchial obstructive syndrome were studied. The effectiveness of the drug Montelukast sodium in bronchial obstruction depending on the severity of clinical and instrumental data was determined.

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Agha, Duaa Shehadahe, and Hind El-zien. "SOLID STATE COMPATIBILITY STUDIES BETWEEN MONTELUKAST SODIUM AND LEVOCETIRIZINE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 368. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.22990.

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Objective: The aim of this research is to evaluate montelukast (MNT)-levocetirizine (LVZ) incompatibility when they gather in one solid dosage form.Methods: Both drugs and their binary mixture (2:1) (MNT-LVZ) were subjected to the following condition: 25°C/60% RH and 40°C/75% RH for 14 weeks. Samples were withdrawn and analyzed using stability-indicating high-performance liquid chromatography (HPLC) method at time intervals (0, 1, 4, 14 weeks). Further investigations were carried out using differential scanning calorimeter (DSC), Fourier transform infrared (FTIR), and X-ray powder diffraction

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Cerruto, Maria Angela, Carolina D’Elia, and Walter Artibani. "A case of eosinophilic cystitis in patients with abdominal pain, dysuria, genital skin hyperemia and slight toxocariasis." Archivio Italiano di Urologia e Andrologia 85, no. 2 (2013): 99. http://dx.doi.org/10.4081/aiua.2013.2.99.

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Eosinophilic cystitis is a rare inflammatory disease with controversial aetiology and treatment. We report the case of a 61-year-old man presented with lower quadrant abdominal pain and lower urinary tract symptoms, non responsive to antibiotics and nonsteroidal antiinflammatory drugs. Physical examination was substantially negative, such as laboratory parameters, microscopic, bacteriological and serological evaluations. Cystoscopy revealed red areas involving the mucosa of the bladder and transurethral biopsies revealed infiltrating eosinophils. The patient was treated with corticosteroids an

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MUHAMMAD ILYAS, FASIHA TARIQ, MAZHAR IFTIKHAR, and NAJAM UL HUSSNAIN KHAN. "COMPARATIVE STUDY OF SECOND GENERATION ANTI HISTAMINE (Cetirizine Hydrochloride 10mg) ALONE VERSUS ANTIHISTAMINE IN COMBINATION WITH LEUKOTRIENE RECEPTOR ANTAGONISTS (Montelukast Sodium 10mg) IN THE TREATMENT OF ALLERGIC RHINITIS." Pakistan Postgraduate Medical Journal 26, no. 3 (2015): 97–102. http://dx.doi.org/10.51642/ppmj.v26i3.150.

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Background: Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by an immunoglobulin Emediated reaction in allergen-sensitized subjects. Allergen avoidance and pharmacotherapy are the cornerstones of allergic rhinitis management. Pharmacotherapy is individualized to the patient based on type of symptoms, their duration and severity, co-morbidities, response to prior treatment and patient preference. Classes of drugs used to treat allergic rhinitis include antihistamines, corticosteroids, mast cell stabilizers, decongestants, nasal anticholinergics, and leukotriene-recepto

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