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1

Demetriades, Helen A. Bipolar disorder, depression, and other mood disorders. Berkeley Heights, NJ: Enslow, 2002.

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2

Chamberlain, Thériault Lea, and Richard Pierrette, eds. On an even keel: Understanding bipolar mood disorder. Beresford, N.B: Publik-Art Ltd, 1992.

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3

Meisel, Abigail. Depression and bipolar disorder: Examining chemical imbalances and mood disorders. Berkeley Heights, NJ: Jasmine Health, an imprint of Enslow Publishers, 2015.

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4

Mood disorders: A practice guide. Philadelphia: Lippincott Williams & Wilkins, 2003.

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5

Child & Adolescent Bipolar Foundation. The Storm in my brain: Kids and mood disorders (Bipolar Disorder and Depression). Wilmette, IL: Child & Adolescent Bipolar Foundation, 2003.

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6

Depression and bipolar disorder: Your guide to recovery. Boulder, CO: Bull Pub. Co., 2012.

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7

Yapko, Michael D. Depression is contagious: How the most common mood disorder is spreading around the world and how to stop it. New York: Free Press, 2009.

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8

M, Stahl S., ed. Depression and bipolar disorder: Stahl's essential psychopharmacology, 3rd edition. Cambridge: Cambridge University Press, 2008.

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9

Mood genes: Hunting for origins of mania and depression. New York: W.H. Freeman, 1998.

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10

Smyth, Angela. SAD: Seasonal affective disorder : who gets it, what causes it, how to cure it. London: Thorsons, 1991.

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11

Smyth, Angela. SAD: Seasonal affective disorder : who gets it, what causes it, how to cure it. London: Thorsons, 1991.

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12

J, Mitchell Alex, ed. Screening for depression: A practical guide for detection and diagnosis of mood disorders. Oxford: Oxford University Press, 2009.

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13

Fawcett, Jan. New hope for people with bipolar disorder. Roseville, Calif: Prima, 2000.

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14

Copeland, Mary Ellen. The depression workbook: A guide for living with depression and manic depression. Oakland, CA: New Harbinger Pubns., 1993.

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15

Matthew, McKay, ed. The depression workbook: A guide for living with depression and manic depression. 2nd ed. Oakland, CA: New Harbinger Publications, 2001.

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16

Matthew, McKay, ed. The depression workbook: A guide for living with depression and manic depression. Oakland, CA: New Harbinger Publications, 1992.

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17

Thase, Michael E. Beating the blues: New approaches to overcoming dysthymia and chronic mild depression. New York: Oxford University Press, 2004.

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18

service), ScienceDirect (Online, ed. Risk factors in depression. Amsterdam: Academic, 2008.

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19

library, Wiley online, ed. Depression and heart disease. Chichester, West Sussex: John Wiley & Sons, 2011.

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20

Parker, James N., and Philip M. Parker. Manic depression: A medical dictionary, bibliography, and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

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21

Parker, Philip M., and James N. Parker. Bipolar affective disorder: A medical dictionary, bibliography and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

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22

Fawcett, Jan. New hope for people with bipolar disorder: Your friendly, authoritative guide to the latest in traditional and complementary solutions. New York: Three Rivers Press, 2007.

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23

Parker, James N., and Philip M. Parker. Manic depressive disorder: A medical dictionary, bibliography, and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

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24

The psychological treatment of depression: A guide to the theory and practice of cognitive behaviour therapy. 2nd ed. London: Routledge, 1992.

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25

Greenspan, Stanley I. Children and babies with mood swings: New insights for parents and professionals. Bethesda, MD: Interdisciplinary Council on Developmental and Learning Disorders, 2007.

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26

Callahan, Christopher M. Reinventing depression: A history of the treatment of depression in primary care, 1940-2004. Oxford: Oxford University Press, 2005.

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27

1952-, Ellison James M., Kyomen Helen, and Verma Sumer, eds. Depression and mood disorders in later life. 2nd ed. New York: Informa Healthcare USA, 2008.

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28

Stoddard, Frederick J., and Robert L. Sheridan. Wound Healing and Depression. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603342.003.0009.

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Depression and wound healing are bidirectional processes for adults and children consistent with the conception of depression as systemic. This systemic interaction is similar to the “bidirectional impact of mood disorder on risk for development, progression, treatment, and outcomes of medical illness” generally. And, evidence is growing that the bidirectional impact of mood disorder may be true for injuries and for trauma surgery. Animal models have provided some support that treatment of depression may improve wound healing. An established biological model for a mechanism delaying wound healing is increased cortisol secretion secondary to depression and/or stress, and impaired immune response, in addition or together with the other factors such as genetic or epigenetic risk for depression. Cellular models relate both to wound healing and to depression include cytokines, the inflammatory response (Miller et al, 2008), and cellular aging (Telgenhoff and Shroot, 2005) reflected in shorter leukocyte telomere length (LTL) (Verhoeven et al, 2016). Another model of stress impacting wound healing investigated genetic correlates—immediate early gene expression or IEG from the medial prefrontal cortex, and locomotion, in isolation-reared juvenile rats. Levine et al (2008) compared isolation reared to group reared samples, and found that, immediate gene expression in the medial prefrontal cortex (mPFC) was reduced, and behavioral hyperactivity increased, in juvenile rats with 20% burn injuries. Wound healing in the isolation reared rats was significantly impaired. They concluded that these results provide candidates for behavioral biomarkers of isolation rearing during physical injury, i.e. reduced immediate mPFC gene expression and hyperactivity. They suggested that a biomarker such as IEGs might aid in demarcating patients with resilient and adaptive responses to physical illness from those with maladaptive responses
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29

(Editor), James E. Ellison, Helen Kyomen (Editor), and Sumer K. Verma (Editor), eds. Depression and Mood Disorders in Later Life, Second Edition (Medical Psychiatry Series). 2nd ed. Informa Healthcare, 2008.

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30

Alder, Catherine A., Mary Guerriero Austrom, Michael A. LaMantia, and Malaz A. Boustani. Aging Brain Care. Edited by Robert E. Feinstein, Joseph V. Connelly, and Marilyn S. Feinstein. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190276201.003.0008.

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While fragmented care is a problem across the entire health care delivery system, it is especially problematic for vulnerable older adults with dementia and late-life depression. Most older adults have multiple chronic conditions. Cognitive impairment and mood disorders complicate the management of these comorbid conditions by interfering with the patient’s ability to monitor and report symptoms and comply with the care plan. To reduce fragmentation and promote integrated care, each medical provider must adopt a more holistic view of health care, recognizing the importance of communication and collaboration among all providers and the potential impact of any one action on the patient’s overall health. The Aging Brain Care (ABC) model provides a structure for integrating evidence-based interventions for dementia and depression into the primary care environment. By extending the delivery of care beyond the clinic, ABC offers patient-centered services aimed at coordinating care across multiple providers, settings, and community resources.
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31

Copeland, Mary Ellen. Living Without Depression and Manic Depression: A Workbook for Maintaining Mood Stability. New Harbinger Pubns Inc, 1994.

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32

Demetriades, Helen A. Bipolar Disorder, Depression, and Other Mood Disorders (Diseases and People). Enslow Publishers, 2002.

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33

Hanns, Hippius, Stefanis C. N, Müller-Spahn Franz, CIBA-GEIGY Limited, and International PTD Committee., eds. Research in mood disorders: An update. Seattle: Hogrefe & Huber Publishers, 1994.

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34

Mondimore, Francis Mark. Depression, the Mood Disease (A Johns Hopkins Press Health Book). The Johns Hopkins University Press, 2006.

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35

Mondimore, Francis Mark. Depression, the Mood Disease (A Johns Hopkins Press Health Book). The Johns Hopkins University Press, 1995.

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36

Mondimore, Francis Mark. Depression, the Mood Disease (A Johns Hopkins Press Health Book). The Johns Hopkins University Press, 1989.

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37

Depression, the Mood Disease (A Johns Hopkins Press Health Book). The Johns Hopkins University Press, 2006.

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38

Copeland, Mary Ellen. Living Without Depression and Manic Depression: A Workbook for Maintaining Mood Stability (New Harbinger Workbooks). New Harbinger Publications, 1994.

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39

Youngstrom, Eric, and Anna Van Meter. Comorbidity of Bipolar Disorder and Depression. Edited by C. Steven Richards and Michael W. O'Hara. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199797004.013.003.

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There has been speculation about the relationship between depression and mania for centuries. Modern psychiatry and psychology have mostly viewed these as different subtypes within a “family” of mood disorders. Conceptual models of comorbidity provide an opportunity to re-examine the association between depression and other pathological mood states. We examine the evidence pertaining to rates of “comorbidity,” which, in this case, refer to the lifetime occurrence of depression and hypomanic, mixed, or manic episodes in the same individual. We explore factors that could contribute to artifactual comorbidity. We also examine data pertaining to similarities or differences in phenomenology, longitudinal course, associated features, family history, and treatment response. Multiple factors are likely involved in the comorbidity of depression and hypomania or mania, and the problems of poor reliability and inconsistent diagnostic definitions and methodology attenuate the significance of most research findings. However, evidence appears sufficient to conclude that not all depression is on the bipolar spectrum, that bipolar features moderate the course and outcome of depressive illness, and that depression and bipolar disorder most likely involve a blend of some shared and some specific mechanisms. Research and clinical work both will advance substantially by more systematically assessing for potential bipolar features “comorbid” with depression and following how these factors change the trajectory of depression over time.
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40

Fertuck, Eric A., Megan S. Chesin, and Brian Johnston. Borderline Personality Disorder and Mood Disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199997510.003.0011.

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Borderline personality disorder (BPD) and mood disorder (MD) can be difficult to differentiate from each other due to several overlapping clinical features. Among BPD symptoms, chronic dysphoria can be mistaken for major depression, while affective instability may be confused with the depressed and elevated mood episodes of bipolar disorder (BD). Conversely, in those with BPD, co-occurring MDs can be difficult to rigorously assess and treat. Even though there is moderate to high co-occurrence between these conditions, BPD and MDs have distinct facets of impulsivity, affective instability, and mood symptoms. Furthermore, BPD, MD, and their co-occurrence predict courses of illness, prognosis, treatment outcomes, and suicide risk. Consequently, thorough assessment and differential diagnosis of these conditions should inform treatment planning and clinical management in both BPD and MD.
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41

(Editor), Gordon Parker, and Dusan Hadzi-Pavlovic (Editor), eds. Melancholia: A Disorder of Movement and Mood: A Phenomenological and Neurobiological Review. Cambridge University Press, 1996.

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42

1942-, Parker Gordon, and Hadzi-Pavlovic Dusan, eds. Melancholia: A disorder of movement and mood : a phenomenological and neurobiological review. Cambridge: Cambridge Unniversity Press, 1996.

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43

Najavits, Lisa M., and Nicole M. Capezza. Depression and Posttraumatic Stress Disorder Comorbidity. Edited by C. Steven Richards and Michael W. O'Hara. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199797004.013.029.

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Depression and posttraumatic stress disorder (PTSD) are highly comorbid diagnoses following a traumatic event. In this chapter, we explore a range of topics related to comorbid depression and PTSD, including impact, prevalence, shared risk factors, temporal priority, key research areas, intervention strategies, and future research directions. Given the overlap in symptoms and shared risk factors, some researchers have suggested that the comorbidity between depression and PTSD following a traumatic event may be better understood as a single general mood disorder rather than two separate disorders. We examine evidence supporting both possibilities. We briefly review the two research areas that have received the most attention, namely comorbidity related to military traumas and interpersonal abuse. Practical implications, assessments, interventions, and treatment recommendations are also discussed.
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44

Mood Disorders: A Practical Guide (Practical Guides in Psychiatry). 2nd ed. Lippincott Williams & Wilkins, 2007.

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45

Ghaemi, S. Nassir. Mood Disorders: A Practical Guide (Practical Guides in Psychiatry). Lippincott Williams & Wilkins, 2003.

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46

(Editor), C. N. Stefanis, Hanns Hippius (Editor), Ciba-Geigy Limited (Corporate Author), International Ptd Committee (Corporate Author), and F. Muller-Spahn (Editor), eds. Research in Mood Disorders: An Update (Psychiatry in Progress, Vol 1). Hogrefe & Huber Publishing, 1994.

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47

Understanding Depression. New York: John Wiley & Sons, Ltd., 2002.

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48

Baer, L., A. Fang, N. C. Berman, and W. E. Minichiello. Mood and Anxiety Disorder Comorbidity in OCD. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0054.

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Primary OCD, like primary anxiety disorders, has high rates of both current and lifetime comorbidity, with a range of mood and anxiety disorders typically greater than 50% and 75%, respectively. This chapter begins with a review of several recent large-scale studies of OCD sufferers on three continents, indicating high levels of mood and anxiety comorbidity. Possible explanations for this high degree of comorbidity are reviewed, including flaws in the current diagnostic system and personality, neurobiological, and cognitive problems that may underlie both OCD and comorbid disorders; this may also account for their considerable phenomenological overlap. It reviews the lack of strong evidence for a negative impact of mood or anxiety comorbidity on OCD treatment outcome, and provides guidance for clinicians in: (1) differential diagnosis between OCD and related conditions including social anxiety, generalized anxiety, illness anxiety, and depression, and (2) suggestions to tailor exposure-based treatment for OCD sufferers with these comorbidities.
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49

Schneck, Christopher. Treating Depression and Bipolar Disorder in Integrated Care Settings. Edited by Robert E. Feinstein, Joseph V. Connelly, and Marilyn S. Feinstein. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190276201.003.0012.

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Primary care clinics are the de facto treatment settings for patients with major depression and bipolar disorder. Primary care patients with mood disorders are more difficult to assess and treat than patients without such disorders, often have comorbid medical and psychiatric conditions, and require greater practice resources for optimal management. Because current treatment of mood disorder patients in primary care settings is often minimally adequate, changes in overall management strategies are needed to improve outcomes. This chapter describes pathways by which primary care providers can implement an integrated care and collaborative model likely to improve patient outcomes. It describes the epidemiology and costs of mood disorders, as well as basic pharmacologic and psychosocial approaches useful in primary care settings. Depressed patients who are refractory to treatment and patients with bipolar disorder are more complicated to manage and almost always require collaboration with a behavioral health specialist and a consulting psychiatrist.
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50

De Aquino, João Paulo, and Robert Beech. Mood Stabilizer Monotherapy versus Adjunctive Antidepressant for Bipolar Depression. Edited by Ish P. Bhalla, Rajesh R. Tampi, Vinod H. Srihari, and Michael E. Hochman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190625085.003.0004.

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This chapter provides a summary of a landmark study on bipolar disorder, which aims to address the following question: In patients with bipolar disorder receiving mood-stabilizing agents, does adjunctive antidepressant therapy reduce the symptoms of bipolar depression without increasing the risk for mania? Starting with that question, the chapter describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints and results, in addition criticisms and limitations. Subsequently, other relevant studies are briefly reviewed and their clinical implications are discussed. Finally, a relevant clinical exemplifies the application of the current evidence behind the clinical question addressed by the study.
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