Relevant bibliographies by topics / Morbidostat

Contents

  1. Journal articles
  2. Book chapters

Academic literature on the topic 'Morbidostat'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Morbidostat.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Morbidostat"

1

Verhoeven, Els, Said Abdellati, Patrick Nys, et al. "Construction and optimization of a ‘NG Morbidostat’ - An automated continuous-culture device for studying the pathways towards antibiotic resistance in Neisseria gonorrhoeae." F1000Research 8 (April 26, 2019): 560. http://dx.doi.org/10.12688/f1000research.18861.1.

Full text
Abstract:
To obtain a detailed picture of the dynamics of antibiotic resistance development in Neisseria gonorrhoeae, we built a morbidostat according to the protocol of Toprak et al., adjusted to the specific characteristics required for the growth of N. gonorrhoeae. In this article we describe the adaptations, specifications and the difficulties we encountered during the construction and optimization of the NG morbidostat. As a proof of concept, we conducted a morbidostat experiment by increasing concentrations of azithromycin in response to bacterial growth. We started the experiment with two N. gono
APA, Harvard, Vancouver, ISO, and other styles
2

Verhoeven, Els, Said Abdellati, Patrick Nys, et al. "Construction and optimization of a ‘NG Morbidostat’ - An automated continuous-culture device for studying the pathways towards antibiotic resistance in Neisseria gonorrhoeae." F1000Research 8 (January 8, 2020): 560. http://dx.doi.org/10.12688/f1000research.18861.2.

Full text
Abstract:
To obtain a detailed picture of the dynamics of antibiotic resistance development in Neisseria gonorrhoeae, we built a morbidostat according to the protocol of Toprak et al., adjusted to the specific characteristics required for the growth of N. gonorrhoeae. In this article we describe the adaptations, specifications and the difficulties we encountered during the construction and optimization of the NG morbidostat. As a proof of concept, we conducted a morbidostat experiment by increasing concentrations of azithromycin in response to bacterial growth. We started the experiment with two N. gono
APA, Harvard, Vancouver, ISO, and other styles
3

Fridman, Ofer, Amir Goldberg, and Nathalie Q. Balaban. "Whack-an-E. coli with the morbidostat." Genome Biology 13, no. 1 (2012): 140. http://dx.doi.org/10.1186/gb-2012-13-1-140.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Cheng, Ziran, and Sze-Bi Hsu. "Dynamics of drug on-drug off models with mutations in morbidostat — Dedicated to the seventieth birthday of Professor Gail Wolkowicz." AIMS Mathematics 8, no. 9 (2023): 20815–40. http://dx.doi.org/10.3934/math.20231061.

Full text
Abstract:
<abstract><p>The morbidostat is a bacteria culture device that progressively increases antibiotic drug concentration. It is used to study the evolutionary pathway. In this article, we construct mathematical models for the morbidostat. First we consider the case of no mutations, we study limiting systems and obtain criteria for the large time behavior of the solutions. From the theoretical results and numerical simulations, we conclude that there are two competitive exclusion states of either wild type or mutant type as the threshold parameter $ U $ varies. There are three cases, wi
APA, Harvard, Vancouver, ISO, and other styles
5

Pedreira, Adrián, José A. Vázquez, Andrey Romanenko, and Míriam R. García. "Design and Validation of a PLC-Controlled Morbidostat for Investigating Bacterial Drug Resistance." Bioengineering 11, no. 8 (2024): 815. http://dx.doi.org/10.3390/bioengineering11080815.

Full text
Abstract:
During adaptive laboratory evolution experiments, any unexpected interruption in data monitoring or control could lead to the loss of valuable experimental data and compromise the integrity of the entire experiment. Most homemade mini-bioreactors are built employing microcontrollers such as Arduino. Although affordable, these platforms lack the robustness of the programmable logic controller (PLC), which enhances the safety and robustness of the control process. Here, we describe the design and validation of a PLC-controlled morbidostat, an innovative automated continuous-culture mini-bioreact
APA, Harvard, Vancouver, ISO, and other styles
6

Chen, Zhenzhen, Sze-Bi Hsu, and Ya-Tang Yang. "The Morbidostat: A Bio-reactor That Promotes Selection for Drug Resistance in Bacteria." SIAM Journal on Applied Mathematics 77, no. 2 (2017): 470–99. http://dx.doi.org/10.1137/16m105695x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Chen, Zhenzhen, Sze-Bi Hsu, and Ya-Tang Yang. "The continuous morbidostat: A chemostat with controlled drug application to select for drug resistance mutants." Communications on Pure & Applied Analysis 19, no. 1 (2020): 203–20. http://dx.doi.org/10.3934/cpaa.2020011.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Toprak, Erdal, Adrian Veres, Sadik Yildiz, et al. "Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition." Nature Protocols 8, no. 3 (2013): 555–67. http://dx.doi.org/10.1038/nprot.2013.021.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Laumen, J. G. E., S. S. Manoharan-Basil, E. Verhoeven, et al. "Molecular pathways to high-level azithromycin resistance in Neisseria gonorrhoeae." Journal of Antimicrobial Chemotherapy 76, no. 7 (2021): 1752–58. http://dx.doi.org/10.1093/jac/dkab084.

Full text
Abstract:
Abstract Background The prevalence of azithromycin resistance in Neisseria gonorrhoeae is increasing in numerous populations worldwide. Objectives To characterize the genetic pathways leading to high-level azithromycin resistance. Methods A customized morbidostat was used to subject two N. gonorrhoeae reference strains (WHO-F and WHO-X) to dynamically sustained azithromycin pressure. We tracked stepwise evolution of resistance by whole genome sequencing. Results Within 26 days, all cultures evolved high-level azithromycin resistance. Typically, the first step towards resistance was found in tr
APA, Harvard, Vancouver, ISO, and other styles
10

González, Natalia, Jolein Gyonne Elise Laumen, Saïd Abdellati, et al. "Pre-exposure to azithromycin enhances gonococcal resilience to subsequent ciprofloxacin exposure: an in vitro study." F1000Research 11 (December 9, 2022): 1464. http://dx.doi.org/10.12688/f1000research.126078.1.

Full text
Abstract:
Background: The effect of sequential exposure to different antibiotics is an underexplored topic. Azithromycin can be detected in humans for up to 28 days post-ingestion and may prime bacterial responses to subsequently ingested antibiotics. Methods: In this in vitro study, we assessed if preexposure to azithromycin could accelerate the acquisition of resistance to ciprofloxacin in Neisseria gonorrhoeae reference strain, WHO–F. In a morbidostat, we set two conditions in 3 vials each: mono-exposure (preexposure to Gonococcal Broth followed by exposure to ciprofloxacin) and dual sequential expos
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Morbidostat"

1

Martínez López, Nerea, Adrián Pedreira, and Míriam R. García. "Control predictivo basado en modelo como alternativa al modo de operación estándar en morbidostato." In XLIII Jornadas de Automática: libro de actas: 7, 8 y 9 de septiembre de 2022, Logroño (La Rioja), 2022nd ed. Servizo de Publicacións da UDC, 2022. http://dx.doi.org/10.17979/spudc.9788497498418.0552.

Full text
Abstract:
El morbidostato es un dispositivo de control asistido por ordenador diseñado para estudiar, en tiempo real, la dinámica fenotípica y genotípica de la adaptación y resistencia bacterianas. Dicho sistema incorpora un mecanismo encargado de activar o desactivar el flujo de cierta sustancia antimicrobiana hacia una serie de microreactores, dependiendo de mediciones en línea de la densidad óptica de la población, con el fin de mantener una concentración bacteriana estable en los diferentes cultivos. Así, por medio del componente de control, el morbidostato ejerce una presión constante sobre la sele
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Morbidostat' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography