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Journal articles on the topic 'MoRF'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Katsumoto, Takuo, and Issay Kitabayashi. "Roles of Histone Acetyltransferase MORF and MOZ in Hematopoiesis." Blood 114, no. 22 (November 20, 2009): 2525. http://dx.doi.org/10.1182/blood.v114.22.2525.2525.

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Abstract Abstract 2525 Poster Board II-502 MOZ (MOnocytic leukemia Zinc finger protein) and MORF (MOz Related Factor), Myst-type histone acetyltransferases, are involved in chromosome translocations associated with FAB-M4/5 subtypes of acute myeloid leukemia. We have reported that MOZ is essential for hematopoietic cell development and self-renewal of hematopoietic stem cells. To explore the possibility MORF also plays important roles in hematopoiesis, we generated Morf-deficient mice with homologous recombination methods. Morf−/− mice were smaller than their wildtype littermates and died within 4 weeks after birth on C57BL/6 background. In MORF−/− fetal liver, Flt3-negative KSL (c-Kit+ Sca-1+ Lineage-) cells containing hematopoietic stem cells were decreased. When fetal liver cells were transplanted into irradiated recipient mice, MORF−/− cells less efficiently reconstituted hematopoiesis than wild-type cells. Additionally, bone marrow cells reconstituted with MORF−/− cells rarely contributed to hematopoiesis in secondary transplants. To reveal relationship between MORF and MOZ in hematopoiesis, we generated double heterozygous (Moz+/− Morf+/−) mouse. Double heterozygous mice were smaller than wild-type littermates and died at least 4 weeks after birth. Numbers of KSL cells, especially Flt3- KSL cells and common myeloid progenitors were decreased in the double heterozygous embryos. The double heterozygous fetal liver cells also displayed less activity to reconstitute hematopoiesis than MOZ+/− or MORF+/− cells. Since MORF−/− mice and MOZ/MORF double heterozygous mice were alive at adult on a mixed C57BL/6/DBA2 genetic background, we investigated adult hematopoiesis in these mice. MORF−/− or MOZ/MORF double heterozygous mice were smaller than their wild-type littermates and had small numbers of thymocytes and splenocytes. However, there were no significant differences in number of bone marrow cells and hematopoietic lineage population in MORF−/− or MOZ/MORF double heterozygous mice. These results suggest that MORF as well as MOZ plays important roles in self-renewal of hematopoietic stem cells. Disclosures: No relevant conflicts of interest to declare.

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2

Wang, Yi, Xinrong Liu, Kayoko Nakamura, Ling Chen, Mary Rusckowski, and Donald J. Hnatowich. "In Vivo Delivery of Antisense MORF Oligomer by MORF/Carrier Streptavidin Nanoparticles." Cancer Biotherapy and Radiopharmaceuticals 24, no. 5 (October 2009): 573–78. http://dx.doi.org/10.1089/cbr.2009.0624.

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3

Prihantoro, Prihantoro. "Current Implementation and Future Prospects of Santi-Morf V.1.0." Ranah: Jurnal Kajian Bahasa 10, no. 2 (December 27, 2021): 411. http://dx.doi.org/10.26499/rnh.v10i2.4189.

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SANTI-Morf (Prihantoro, 2021) is a new morphological analyser for Indonesian. In SANTI-Morf annotation scheme (Prihantoro, 2019), morpheme tokens are linked to their annotations. The tokens are presented in their orthographic and citation forms to allow (allo)morph or morpheme-based searches. Users can also perform retrievals on the basis of formal and functional morphological criteria as SANTI-Morf tagset encodes the analyses of morphemes’ forms (e.g. roots, clitics, affix type) and functions (e.g. passive voice, active voice, adjective degrees, etc.). Currently, the scheme is implemented in Nooj (Silberztein, 2003), a linguistic development environment. It enables users to index and annotate Indonesian texts in their local PC, and later perform searches based on morphological criteria and or tokens defined by the SANTI-Morf scheme. AbstrakSANTI-Morf (Prihantoro, 2021) adalah sebuah program analisis morfologi terbaru untuk bahasa Indonesia. Dalam skema anotasi SANTI-morf (Prihantoro, A new tagset for morphological analysis of Indonesian, 2019), setiap token morfem terhubung dengan anotasinya. Token-token ini direpresentasikan dalam bentuk ortografis dan bentuk sitasi sehingga memungkinkan pengguna untuk melakukan penelusuran berbasis (alo)morf atau morfem. Selain itu, pengguna juga bisa melakukan penelusuran berbasiskan bentuk atau fungsi morfem. Ini karena tagset analitik yang digunakan di SANTI-morf mencakup bentuk (di antaranya: akar, klitik, jenis afiksasi) dan fungsi (di antaranya: aktif, pasif, derajat ajektiva). Saat ini, SANTI-morf diimplementasikan menggunakan NooJ (Silberztein, 2003), sebuah program pengembangan aplikasi linguistik. Pengguna dapat mengindeks dan menganotasi teks berbahasa Indonesia di komputer mereka, dan selanjutnya melakukan penelusuran menggunakan kriteria morfologi dan skema tokenisasi yang digunakan di skema anotasi SANTI-morf.

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4

Xiong, Yuhong, Jing Fang, Xiaohan Jiang, Tengfei Wang, Kangchen Liu, Huixiang Peng, Xiujun Zhang, and Aidi Zhang. "Genome-Wide Analysis of Multiple Organellar RNA Editing Factor (MORF) Family in Kiwifruit (Actinidia chinensis) Reveals Its Roles in Chloroplast RNA Editing and Pathogens Stress." Plants 11, no. 2 (January 6, 2022): 146. http://dx.doi.org/10.3390/plants11020146.

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Kiwifruit (Actinidia chinensis) is well known for its high vitamin C content and good taste. Various diseases, especially bacterial canker, are a serious threat to the yield of kiwifruit. Multiple organellar RNA editing factor (MORF) genes are pivotal factors in the RNA editosome that mediates Cytosine-to-Uracil RNA editing, and they are also indispensable for the regulation of chloroplast development, plant growth, and response to stresses. Although the kiwifruit genome has been released, little is known about MORF genes in kiwifruit at the genome-wide level, especially those involved in the response to pathogens stress. In this study, we identified ten MORF genes in the kiwifruit genome. The genomic structures and chromosomal locations analysis indicated that all the MORF genes consisted of three conserved motifs, and they were distributed widely across the seven linkage groups and one contig of the kiwifruit genome. Based on the structural features of MORF proteins and the topology of the phylogenetic tree, the kiwifruit MORF gene family members were classified into six groups (Groups A–F). A synteny analysis indicated that two pairs of MORF genes were tandemly duplicated and five pairs of MORF genes were segmentally duplicated. Moreover, based on analysis of RNA-seq data from five tissues of kiwifruit, we found that both expressions of MORF genes and chloroplast RNA editing exhibited tissue-specific patterns. MORF2 and MORF9 were highly expressed in leaf and shoot, and may be responsible for chloroplast RNA editing, especially the ndhB genes. We also observed different MORF expression and chloroplast RNA editing profiles between resistant and susceptible kiwifruits after pathogen infection, indicating the roles of MORF genes in stress response by modulating the editing extend of mRNA. These results provide a solid foundation for further analyses of the functions and molecular evolution of MORF genes, in particular, for clarifying the resistance mechanisms in kiwifruits and breeding new cultivars with high resistance.

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Xia, Ting, Zhi-Yong Yu, and Han-Yuan Gong. "Pb2+-Containing Metal-Organic Rotaxane Frameworks (MORFs)." Molecules 26, no. 14 (July 13, 2021): 4241. http://dx.doi.org/10.3390/molecules26144241.

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The metal-organic rotaxane framework (MORF) structures with the advantage of mechanically interlocking molecules (MIMs) have attracted intense interest from the chemical community. In this study, a set of MORFs (i.e., MORF-Pb-1 and MORF-Pb-2) are constructed using Pb2+, a tetraimidazolium macrocycle (Texas-sized molecular box; 14+), and aromatic dicarboxylate (p-phthalate dianions (PTADAs; 2) or 2,6-naphthalene dicarboxylate dianions (3)) via a one-pot three-layer diffusion protocol. In particular, an unusual Pb…Pb weak interaction was shown in MORF-Pb-1 (charactered with distance of 3.656 Å).

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6

Ullah, Mukta, Nadine Pelletier, Lin Xiao, Song Ping Zhao, Kainan Wang, Cindy Degerny, Soroush Tahmasebi, et al. "Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes." Molecular and Cellular Biology 28, no. 22 (September 15, 2008): 6828–43. http://dx.doi.org/10.1128/mcb.01297-08.

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ABSTRACT The monocytic leukemia zinc finger protein MOZ and the related factor MORF form tetrameric complexes with ING5 (inhibitor of growth 5), EAF6 (Esa1-associated factor 6 ortholog), and the bromodomain-PHD finger protein BRPF1, -2, or -3. To gain new insights into the structure, function, and regulation of these complexes, we reconstituted them and performed various molecular analyses. We found that BRPF proteins bridge the association of MOZ and MORF with ING5 and EAF6. An N-terminal region of BRPF1 interacts with the acetyltransferases; the enhancer of polycomb (EPc) homology domain in the middle part binds to ING5 and EAF6. The association of BRPF1 with EAF6 is weak, but ING5 increases the affinity. These three proteins form a trimeric core that is conserved from Drosophila melanogaster to humans, although authentic orthologs of MOZ and MORF are absent in invertebrates. Deletion mapping studies revealed that the acetyltransferase domain of MOZ/MORF is sufficient for BRPF1 interaction. At the functional level, complex formation with BRPF1 and ING5 drastically stimulates the activity of the acetyltransferase domain in acetylation of nucleosomal histone H3 and free histones H3 and H4. An unstructured 18-residue region at the C-terminal end of the catalytic domain is required for BRPF1 interaction and may function as an “activation lid.” Furthermore, BRPF1 enhances the transcriptional potential of MOZ and a leukemic MOZ-TIF2 fusion protein. These findings thus indicate that BRPF proteins play a key role in assembling and activating MOZ/MORF acetyltransferase complexes.

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7

Benlamri, Rachid, and Luke Docksteader. "MORF: A Mobile Health-Monitoring Platform." IT Professional 12, no. 3 (May 2010): 18–25. http://dx.doi.org/10.1109/mitp.2010.3.

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8

Wong, J., D. Lee, M. Mangada, V. Yadav, D. Troast, C. Zhong, K. Hahn, et al. "DOP50 Oral α4β7 integrin inhibitor MORF-057 demonstrates exposure driven biomarker response in non-human primates." Journal of Crohn's and Colitis 16, Supplement_1 (January 1, 2022): i098—i099. http://dx.doi.org/10.1093/ecco-jcc/jjab232.089.

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Abstract Background Disruption of immune cell trafficking via integrins is a proven and effective mechanism for treating inflammatory bowel disease. When α4β7 integrin is inhibited through pharmacological intervention, immune cells destined for the gut tissue become sequestered in blood circulation and these alterations can be detected through several methods. MORF-057 is a novel, oral, selective, small molecule inhibitor of α4β7 integrin developed for treating IBD. MORF-057 demonstrated favorable tolerability, pharmacokinetic and pharmacodynamic profiles including saturating receptor occupancy and corresponding evidence for proof of biology based on effects on circulating cells during a Phase 1 clinical trial in healthy volunteers (Ray, ECCO 2021). Here we demonstrate an exposure:response relationship of α4β7 related biomarkers examined among MORF-057 treated non-human primates (NHPs) as a means for pre-clinical testing of inhibitors of this pathway. Methods Single-cell RNA sequencing (scRNAseq) was performed on NHP CD45+ blood cells to determine baseline populations potentially impacted through exposure to MORF-057. 40 Naïve cynomolgus monkeys were enrolled over 5 separate studies and dosed orally BID with MORF-057 over 2–7 days using several dose levels to examine biomarker dynamics over a wide range of exposures. Peripheral blood was sampled at various timepoints (n= 125) and assayed using: mass spectroscopy, flow cytometry (FACS), and mRNA quantification to determine MORF-057 exposure levels, on-target receptor occupancy (RO), immune cell subset changes, and CCR9 mRNA levels. Results MORF-057 Ctrough ranged from 3.3–429 ng/ml. In samples tested for RO, MORF-057 achieved >95% saturation of α4β7 even with the lowest Ctrough of 4.5 ng/ml. MORF-057 treatment led to significantly sustained increases in circulating β7high CD4+ T memory cells detectable as early as 24h post-exposure. A maximal effect where β7high cells accounted for approximately 60% of the T memory population was achieved at saturating receptor occupancy (Fig., left). CCR9 mRNA values demonstrated increases upon drug exposure (Fig., right). Conclusion In NHP, acute changes in circulating β7high T memory cells was a sensitive biomarker demonstrating a dose-dependent response to MORF-057 exposure. CCR9 mRNA levels also showed similar exposure related changes reflecting its expression on a subset of β7high cell types. Analysis of scRNAseq shows expression of α4β7 on other cell types beyond T memory cells including: NK, NKT, B cells, plasmablasts, monocytes, and eosinophils. Pharmacodynamic changes in NHP are consistent with human Phase 1 data in healthy volunteers.

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9

Jones, J., D. Lee, I. Smukste, D. Cui, M. G. Bursavich, D. Troast, C. Zhong, et al. "P037 Nonclinical pharmacokinetics and absorption, distribution, metabolism, and excretion properties of MORF-057 support its clinical development as an oral selective α4β7 integrin inhibitor." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S149—S150. http://dx.doi.org/10.1093/ecco-jcc/jjab076.166.

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Abstract Background MORF-057 is a potent and selective small molecule inhibitor of the α 4β 7 integrin. Using a receptor occupancy (RO) assay under physiologically relevant conditions, MORF-057 achieves 90% α 4β 7 RO at approximately 10 nM in human whole blood. The current studies evaluate nonclinical pharmacokinetics (PK) and properties of absorption, distribution, metabolism, and excretion (ADME) to enable dose/exposure projection to humans. Methods PK studies were conducted in mouse, rat, dog, and monkey following intravenous (IV) and oral administration. ADME studies were conducted in vitro and in rats using carbon-14 [14C] labeled MORF-057. MORF-057 levels were quantified using liquid chromatography coupled with tandem mass spectrometry. Human PK was predicted based on body weight allometry, well-stirred and semi-physiological models. Results MORF-057 exhibited low to moderate clearance (CL) in animals with species dependent volume of distribution (Vdss) resulting in half-lives of 1.1 to 2.7 hours (Table 1). Following an oral dose, absorption was high with bioavailability ranging from 15% to 49%. MORF-057 is highly protein bound and distribution of [14C]MORF-057 derived radioactivity in rat was predominantly in the small intestine wall, liver, and stomach wall. Rifampin, an inhibitor of organic anion transporting polypeptides, decreased MORF-057 clearance by 3-fold in monkeys suggesting MORF-057 elimination involves hepatic uptake transport. MORF-057 is further cleared via CYP3A metabolism followed by biliary/fecal elimination of metabolites. MORF-057 is predicted to have moderate bioavailability (40%) and CL (6.5 mL/min/kg) in humans. Wajima transformation shows good agreement of the normalized PK across animal species, with a predicted human concentration-time profile supporting >90% α 4β 7 RO at trough following 200 mg twice daily dose (Figure 1). Conclusion These data demonstrate that MORF-057 is well absorbed and PK properties in animals support the potential for achieving high α4β7 RO following oral administration in humans. These nonclinical results provided a basis for the progression of MORF-057 into a first-in-human Phase 1 clinical study assessing safety, pharmacokinetics, and receptor occupancy (results being reported separately).

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10

Yochum, Gregory S., and Donald E. Ayer. "Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split." Molecular and Cellular Biology 22, no. 22 (November 15, 2002): 7868–76. http://dx.doi.org/10.1128/mcb.22.22.7868-7876.2002.

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ABSTRACT mSin3A and Transducin-Like Enhancer of Split (TLE) are two histone deacetylase (HDAC)-containing corepressors that function to repress transcription at targeted genes. Pf1 is a plant homeodomain zinc finger protein that interacts with both mSin3A and TLE, suggesting that it coordinates their function. Here we show that mSin3A and TLE interact with members of the mortality factor (MORF) family of putative transcriptional regulators. This family comprises MORF on chromosome 4 (MORF4) and MORF-related genes on chromosomes X and 15 (MRGX and MRG15, respectively) and is proposed to contribute to cellular senescence. Consistent with a role in transcription, we demonstrate that Gal4 fusions to each MORF family member repress transcription from a Gal4-dependent luciferase reporter. By using both mapping experiments and a dominant negative form of TLE, we show that repression by MORFs requires associations with mSin3A and TLE. Therefore, common functions of the MORFs are likely elicited through the action of a MORF/mSin3A/TLE complex. While the MORFs may have common functions, MRG15, but not MRGX or MORF4, interacted with Pf1. Therefore, MRG15 may have functions that are distinct from those of MRGX and MORF4. Consistent with this hypothesis, Pf1 reduced transcriptional repression by Gal4-MRG15 but it had no effect on repression by MRGX and MORF4. Pf1 has independent binding sites for MRG15 and mSin3A. In addition, Pf1 and MRG15 bind different domains on mSin3A. Together, these data suggest that the unique functions of MRG15 are elicited through the action of an MRG15/Pf1/mSin3A complex.

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Trachsler, Richard. "A propos de la correspondance adressée a Heinrich Morf, conservée à la Bibliothek Jud de l'Université de Zurich." Romanische Forschungen 133, no. 1 (March 15, 2021): 90–101. http://dx.doi.org/10.3196/003581221831922355.

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Das Romanische Seminar der Universität Zürich bewahrt in der Forschungsbibliothek Briefe und Unterlagen von Heinrich Morf (1854–1921) auf, dem eigentlichen Begründer des Romanischen Seminars. Dank eines bereits 1960 erfolgten Legats seiner Tochter Gertrud Lehner-Morf konnten mehr als 660 Dokumente aller Art in die Bibliothek überführt werden, jedoch ist das Material erst in den letzten Jahren gesichtet und geordnet worden. Der vorliegende Beitrag versucht, den Fonds Morf vorzustellen und das Potenzial dieses Torsos einer Gelehrtenkorrespondenz für die Erkenntnisse der Forschung zu erläutern. Die interessantesten Dokumente stammen aus der Berliner Zeit und bieten Einblick in die Organisation der Erhebungen in den Gefangenenlagern, deren Leitung für den Bereich der Romanistik Morf oblag.

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Redhu, Naresh S., Ali Hussain, Sathish Srinivasan, Dooyoung Lee, Brianna Bannister, Natalia Blanco, Raegan Bonesteel, et al. "Modeling relationship of pharmacokinetics, in vitro potency, and α4β7 receptor occupancy with intestinal cell trafficking in a gut-homing mouse model of IBD with MORF-057." Journal of Immunology 206, no. 1_Supplement (May 1, 2021): 11.15. http://dx.doi.org/10.4049/jimmunol.206.supp.11.15.

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Abstract Objective: MORF-057 is an orally bioavailable, selective, and potent small molecule inhibitor of α4β7 integrin being developed for inflammatory bowel diseases (IBD) that is currently in phase 1 clinical testing. We have previously presented work that characterized its nonclinical pharmacologic profile. The current study integrates data to generate a pharmacokinetic (PK) and pharmacodynamic (PD) model of MORF-057. Methods: To determine in vivo potency, MORF-057 was tested in murine gut homing assays and the PD response was determined relative to the non-protein bound drug in mouse plasma. A cell adhesion assay (CAA) for α4β7 was refined to enable detection of picomolar-level sensitivity. Murine receptor occupancy (RO) assays for α4β7 and α4β1 were established under physiologic conditions, and MORF-057 was evaluated for its potency and selectivity in fresh mouse whole blood. These datasets were used to build and validate predictive models of PD response. Results: MORF-057 strongly inhibited the homing of α4β7hi cells to murine gut lymphoid tissues with an IC90 of 7.9 nM. MORF-057 showed high potency in CAA with an IC90 of 8.8 nM. Similarly, RO assays confirmed MORF-057 to be a highly potent inhibitor of α4β7 in mouse whole blood with an IC90 of 20.5 nM and over 1500-fold selectivity vs. α4β1. The predictive models built upon these datasets revealed a strong PK-PD relationship of α4β7 inhibitors in vivo. Conclusions: We observed consistently high potency of MORF-057 across multiple assay platforms. Integrated modeling based on these assays, particularly the RO assay, successfully predicted the PD response to MORF-057. These data begin to establish the relationship between PK, target engagement, and PD with MORF-057.

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Klein, Brianna J., Johayra Simithy, Xiaolu Wang, JaeWoo Ahn, Forest H. Andrews, Yi Zhang, Jacques Côté, Xiaobing Shi, Benjamin A. Garcia, and Tatiana G. Kutateladze. "Recognition of Histone H3K14 Acylation by MORF." Structure 25, no. 4 (April 2017): 650–54. http://dx.doi.org/10.1016/j.str.2017.02.003.

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&NA;. "THERE ARE NO CONVENIENCE STORES ON MORF (With Apologies to “Mork and Mindy”)." Southern Medical Journal 83, no. 12 (December 1990): 1463–64. http://dx.doi.org/10.1097/00007611-199012000-00022.

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Hwang Fu, Yu-Hsien, Sowmya Chandrasekar, Jae Ho Lee, and Shu-ou Shan. "A molecular recognition feature mediates ribosome-induced SRP-receptor assembly during protein targeting." Journal of Cell Biology 218, no. 10 (September 19, 2019): 3307–19. http://dx.doi.org/10.1083/jcb.201901001.

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Molecular recognition features (MoRFs) provide interaction motifs in intrinsically disordered protein regions to mediate diverse cellular functions. Here we report that a MoRF element, located in the disordered linker domain of the mammalian signal recognition particle (SRP) receptor and conserved among eukaryotes, plays an essential role in sensing the ribosome during cotranslational protein targeting to the endoplasmic reticulum. Loss of the MoRF in the SRP receptor (SR) largely abolishes the ability of the ribosome to activate SRP-SR assembly and impairs cotranslational protein targeting. These results demonstrate a novel role for MoRF elements and provide a mechanism for the ribosome-induced activation of the mammalian SRP pathway. Kinetic analyses and comparison with the bacterial SRP further suggest that the SR MoRF functionally replaces the essential GNRA tetraloop in the bacterial SRP RNA, providing an example for the replacement of RNA function by proteins during the evolution of ancient ribonucleoprotein particles.

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He, Jiang, Mary Rusckowski, Yi Wang, Shuping Dou, Xinrong Liu, Surong Zhang, Guozheng Liu, and Donald J. Hnatowich. "Optical Pretargeting of Tumor with Fluorescent MORF Oligomers." Molecular Imaging and Biology 9, no. 1 (December 14, 2006): 17–23. http://dx.doi.org/10.1007/s11307-006-0071-2.

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17

Ray, A., D. Cui, D. Lee, M. M. Mangada, J. Jones, G. Bain, P. G. Traber, et al. "P306 MORF-057, an oral selective α4β7 integrin inhibitor for Inflammatory Bowel Disease, leads to specific target engagement in a single and multiple ascending dose study in healthy subjects." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S333—S335. http://dx.doi.org/10.1093/ecco-jcc/jjab076.430.

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Abstract Background MORF-057 is an orally administered small molecule designed to inhibit the α 4β 7 receptor, addressing an unmet medical need in inflammatory bowel disease (IBD) patients, and avoiding the need for periodic therapeutic infusions and the risk for infusion-related reactions. This study evaluated single (SAD) and multiple ascending doses (MAD) of MORF-057 in healthy volunteers. Methods This was a randomized, double-blind, placebo-controlled, single and multiple doses, phase 1 study of the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of MORF-057 conducted in a Phase I Unit in the USA. Subjects were randomized 3:1 to MORF-057 or placebo capsules once daily in the SAD cohorts: 25, 50, 100, 150, and 400 mg; or twice daily (BID) in the MAD cohorts: 100 and 200 mg total daily doses (dosed as 50 and 100 mg BID, respectively). In the MAD cohorts, trough PK samples were obtained premorning or pre-evening dose following administration of 50 or 100 mg BID, respectively. Blood samples to assess receptor occupancy (RO) of α 4β 7 and α 4β 1 integrins were obtained prior to the first dose and 12 hours after treatment. Results To date, 51 healthy subjects were dosed; 1 subject withdrew consent on Day 2 for personal reasons. Eleven non-serious adverse events (AEs) were reported; AEs were mild and did not result in discontinuation. Two reversible mild AEs in the 200 mg MAD cohort were possibly related to MORF-057 (macular / maculopapular rash). No safety signals were identified to date. Following dosing, MORF-057 was rapidly absorbed and systemic exposure increased approximately dose-proportionally (Fig.1). Mean α 4β 7 RO was found to be greater than 95% after each of the three highest single doses (Fig.2). In multiple dosing, mean α 4β 7 RO was greater than 90% at the lower dose, while the highest dose tested resulted in α 4β 7 RO saturation at steady state. α 4β 1 RO was below the limit of quantitation with mean trough values estimated to be <10% at any of the dose levels. Conclusion Current results demonstrated that single and multiple ascending doses of MORF-057 were well tolerated, with only mild, non-serious AEs reported that did not result in study drug discontinuation. MORF-057 demonstrated a favorable PK profile where target engagement was confirmed and resulted in α4β7 receptor saturation in many subjects receiving higher doses. These results support further investigation of MORF-057 and provide a basis for dose selection phase 2 studies in patients with IBD. (NCT04580745)

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Wijana, I. Dewa Putu. "Informal Bound Morphs in Indonesian." Jurnal Bastrindo 2, no. 2 (December 31, 2021): 91–100. http://dx.doi.org/10.29303/jb.v2i2.213.

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Abstrak: Makalah ini membahas penggunaan morf terikat informal dalam bahasa Indonesia. Ada beberapa masalah yang ingin dijawab, yaitu apa morf terikat bahasa Indonesia yang biasa ditemukan dalam situasi tutur informal, berbagai makna gramatikal dapat diungkapkan oleh morf terikat tersebut, dan bagaimana kata-kata yang mengandung morf tersebut dapat diparafrasekan untuk mengidentifikasi padanan formalnya. Dengan menggunakan data yang dikumpulkan dari beberapa sumber dan menciptakan penggunaan kontekstualnya secara introspektif, ditemukan bahwa setidaknya ada lima morf terikat informal dalam penggunaan bahasa Indonesia. Beberapa dari morf terikat tersebut bersifat informal dalam semua penggunaan kontekstual, dan beberapa lainnya hanya demikian dalam mengungkapkan makna tertentu. Semua morf informal tersebut memiliki korespondensi formal meskipun dalam kasus yang sangat jarang parafrasenya tampak sangat aneh dan sulit dimengerti. Abstract: This paper deals with the use of informal bound morphs in Indonesian. There are several issues intend to be answered, i.e what are Indonesian bound morphs commonly found in informal speech situations, various grammatical meanings can be expressed by those bound morphs, and how the words containing such morphs could be paraphrased to identify their formal equivalents. By using data collected from several sources and creating their contextual usage introspectively, it is found that there are at least five informal bound morphs in the use of Indonesian. Several of those bound morphs are informal in all contextual usages, and several others are only so in expressing certain meanings. All of those informal morphs have formal correspondences eventhough in very rare cases the paraphrases seem very strange and hard to understand.

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Ullah, Mukta, Nadine Pelletier, Lin Xiao, Song Ping Zhao, Kainan Wang, Cindy Degerny, Soroush Tahmasebi, et al. "Molecular Architecture of Quartet MOZ/MORF Histone Acetyltransferase Complexes." Molecular and Cellular Biology 29, no. 3 (February 1, 2009): 942. http://dx.doi.org/10.1128/mcb.01901-08.

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Wang, Dongli, Sen Meng, Wanlong Su, Yu Bao, Yingying Lu, Weilun Yin, Chao Liu, and Xinli Xia. "Genome-Wide Analysis of Multiple Organellar RNA Editing Factor Family in Poplar Reveals Evolution and Roles in Drought Stress." International Journal of Molecular Sciences 20, no. 6 (March 21, 2019): 1425. http://dx.doi.org/10.3390/ijms20061425.

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Poplar (Populus) is one of the most important woody plants worldwide. Drought, a primary abiotic stress, seriously affects poplar growth and development. Multiple organellar RNA editing factor (MORF) genes—pivotal factors in the RNA editosome in Arabidopsis thaliana—are indispensable for the regulation of various physiological processes, including organelle C-to-U RNA editing and plasmid development, as well as in the response to stresses. Although the poplar genome sequence has been released, little is known about MORF genes in poplar, especially those involved in the response to drought stress at the genome-wide level. In this study, we identified nine MORF genes in the Populus genome. Based on the structural features of MORF proteins and the topology of the phylogenetic tree, the P. trichocarpa (Ptr) MORF family members were classified into six groups (Groups I–VI). A microsynteny analysis indicated that two (22.2%) PtrMORF genes were tandemly duplicated and seven genes (77.8%) were segmentally duplicated. Based on the dN/dS ratios, purifying selection likely played a major role in the evolution of this family and contributed to functional divergence among PtrMORF genes. Moreover, analysis of qRT-PCR data revealed that PtrMORFs exhibited tissue- and treatment-specific expression patterns. PtrMORF genes in all group were involved in the stress response. These results provide a solid foundation for further analyses of the functions and molecular evolution of MORF genes in poplar, and, in particular, for improving the drought resistance of poplar by genetics manipulation.

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Klein, Brianna J., Marie-Eve Lalonde, Jacques Côté, Xiang-Jiao Yang, and Tatiana G. Kutateladze. "Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes." Epigenetics 9, no. 2 (October 29, 2013): 186–93. http://dx.doi.org/10.4161/epi.26792.

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22

Sharma, Ronesh, Gaurav Raicar, Tatsuhiko Tsunoda, Ashwini Patil, and Alok Sharma. "OPAL: prediction of MoRF regions in intrinsically disordered protein sequences." Bioinformatics 34, no. 11 (January 18, 2018): 1850–58. http://dx.doi.org/10.1093/bioinformatics/bty032.

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Pelletier, N. "Expression, purification, and analysis of MOZ and MORF histone acetyltransferases." Methods 31, no. 1 (September 2003): 24–32. http://dx.doi.org/10.1016/s1046-2023(03)00084-7.

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24

Moore, Steven D. P., Steven R. Herrick, Tan A. Ince, Michael S. Kleinman, Paola Dal Cin, Cynthia C. Morton, and Bradley J. Quade. "Uterine Leiomyomata with t(10;17) Disrupt the Histone Acetyltransferase MORF." Cancer Research 64, no. 16 (August 15, 2004): 5570–77. http://dx.doi.org/10.1158/0008-5472.can-04-0050.

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25

Mehta, Bhairav Bipin, Dan Ma, Eric Yann Pierre, Yun Jiang, Simone Coppo, and Mark Alan Griswold. "Image reconstruction algorithm for motion insensitive MR Fingerprinting (MRF): MORF." Magnetic Resonance in Medicine 80, no. 6 (May 6, 2018): 2485–500. http://dx.doi.org/10.1002/mrm.27227.

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Sharma, Ronesh, Alok Sharma, Gaurav Raicar, Tatsuhiko Tsunoda, and Ashwini Patil. "OPAL+: Length‐Specific MoRF Prediction in Intrinsically Disordered Protein Sequences." PROTEOMICS 19, no. 6 (November 2, 2018): 1800058. http://dx.doi.org/10.1002/pmic.201800058.

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27

Moon, Heekyung, Sung H. Han, and Jiyoung Kwahk. "A MORF-Vision Method for Strategic Creation of IoT Solution Opportunities." International Journal of Human–Computer Interaction 35, no. 10 (July 27, 2018): 821–30. http://dx.doi.org/10.1080/10447318.2018.1497896.

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28

Liu, Guozheng, Shuping Dou, Jiang He, Xinrong Liu, Mary Rusckowski, and Donald J. Hnatowich. "Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice." European Journal of Nuclear Medicine and Molecular Imaging 34, no. 2 (September 22, 2006): 237–46. http://dx.doi.org/10.1007/s00259-006-0222-3.

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29

Yang, Xiang-Jiao. "MOZ and MORF acetyltransferases: Molecular interaction, animal development and human disease." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853, no. 8 (August 2015): 1818–26. http://dx.doi.org/10.1016/j.bbamcr.2015.04.014.

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30

Zhang, Qiang, Lan Shen, Deyong Ren, Jiang Hu, Guang Chen, Li Zhu, Zhenyu Gao, et al. "Characterization, Expression, and Interaction Analyses of OsMORF Gene Family in Rice." Genes 10, no. 9 (September 10, 2019): 694. http://dx.doi.org/10.3390/genes10090694.

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The multiple organellar RNA editing factors (MORF) gene family plays a key role in organelle RNA editing in flowering plants. MORF genes expressions are also affected by abiotic stress. Although seven OsMORF genes have been identified in rice, few reports have been published on their expression patterns in different tissues and under abiotic stress, and OsMORF–OsMORF interactions. In this study, we analyzed the gene structure of OsMORF family genes. The MORF family members were divided into six subgroups in different plants based on phylogenetic analysis. Seven OsMORF genes were highly expressed in leaves. Six and seven OsMORF genes expressions were affected by cold and salt stresses, respectively. OsMORF–OsMORF interaction analysis indicated that OsMORF1, OsMORF8a, and OsMORF8b could each interact with themselves to form homomers. Moreover, five OsMORF proteins were shown to be able to interact with each other, such as OsMORF8a and OsMORF8b interacting with OsMORF1 and OsMORF2b, respectively, to form heteromers. These results provide information for further study of OsMORF gene function.

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31

Yang, Xue, Michel Giorgi, Hakim Karoui, Didier Gigmes, Virginie Hornebecq, Olivier Ouari, Anthony Kermagoret, and David Bardelang. "A single-crystal-to-single-crystal transformation affording photochromic 3D MORF crystals." Chemical Communications 55, no. 92 (2019): 13824–27. http://dx.doi.org/10.1039/c9cc07121k.

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32

He, Jiang, Yi Wang, Shuping Dou, Xinrong Liu, Surong Zhang, Guozheng Liu, and Donald Hnatowich. "Affinity Enhancement Pretargeting: Synthesis and Testing of a 99mTc-Labeled Bivalent MORF." Molecular Pharmaceutics 7, no. 4 (June 21, 2010): 1118–24. http://dx.doi.org/10.1021/mp9002909.

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33

Liu, Guozheng, Shuping Dou, Dengfeng Cheng, Jean Leif, Mary Rusckowski, Philip R. Streeter, Leonard D. Shultz, Donald J. Hnatowich, and Dale L. Greiner. "Human Islet Cell MORF/cMORF Pretargeting in a Xenogeneic Murine Transplant Model." Molecular Pharmaceutics 8, no. 3 (April 21, 2011): 767–73. http://dx.doi.org/10.1021/mp100382m.

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34

Liu, Guozheng, Dengfeng Cheng, Shuping Dou, Xiangji Chen, Minmin Liang, P. Hendrik Pretorius, Mary Rusckowski, and Donald J. Hnatowich. "Replacing 99mTc with 111In Improves MORF/cMORF Pretargeting by Reducing Intestinal Accumulation." Molecular Imaging and Biology 11, no. 5 (March 27, 2009): 303–7. http://dx.doi.org/10.1007/s11307-009-0209-0.

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35

Brüning, Barbara. "Philosophieren mit Kindern." ETHICS IN PROGRESS 2, no. 1 (February 1, 2011): 52. http://dx.doi.org/10.14746/eip.2011.1.9.

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Geiger, Michaela. "Erste HP Indigo 6K der Schweiz." PACKaktuell 38, no. 7-8 (2021): 17. http://dx.doi.org/10.51202/1664-6533-2021-7-8-017.

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37

Xue, Peng, Bei Li, Ying An, Jin Sun, Xiaoning He, Rui Hou, Guangying Dong, et al. "Decreased MORF leads to prolonged endoplasmic reticulum stress in periodontitis-associated chronic inflammation." Cell Death & Differentiation 23, no. 11 (July 22, 2016): 1862–72. http://dx.doi.org/10.1038/cdd.2016.74.

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38

Pelletier, Nadine, Nathalie Champagne, Stefano Stifani, and Xiang-Jiao Yang. "MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2." Oncogene 21, no. 17 (April 2002): 2729–40. http://dx.doi.org/10.1038/sj.onc.1205367.

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39

Chen, Xiangji, Shuping Dou, Guozheng Liu, Xinrong Liu, Yi Wang, Ling Chen, Mary Rusckowski, and Donald J. Hnatowich. "Synthesis and in Vitro Characterization of a Dendrimer−MORF Conjugate for Amplification Pretargeting." Bioconjugate Chemistry 19, no. 8 (August 2008): 1518–25. http://dx.doi.org/10.1021/bc8001024.

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40

Liu, Guozheng, Shuping Dou, P. Hendrik Pretorius, Xinrong Liu, Mary Rusckowski, and Donald J. Hnatowich. "Pretargeting CWR22 prostate tumor in mice with MORF-B72.3 antibody and radiolabeled cMORF." European Journal of Nuclear Medicine and Molecular Imaging 35, no. 2 (October 2, 2007): 272–80. http://dx.doi.org/10.1007/s00259-007-0606-z.

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41

Yang, X.-J., and M. Ullah. "MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells." Oncogene 26, no. 37 (August 2007): 5408–19. http://dx.doi.org/10.1038/sj.onc.1210609.

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42

Bertram, M. J., N. G. Bérubé, X. Hang-Swanson, Q. Ran, J. K. Leung, S. Bryce, K. Spurgers, et al. "Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes." Molecular and Cellular Biology 19, no. 2 (February 1, 1999): 1479–85. http://dx.doi.org/10.1128/mcb.19.2.1479.

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ABSTRACT Based on the dominance of cellular senescence over immortality, immortal human cell lines have been assigned to four complementation groups for indefinite division. Human chromosomes carrying senescence genes have been identified, including chromosome 4. We report the cloning and identification of a gene, mortality factor 4 (MORF 4), which induces a senescent-like phenotype in immortal cell lines assigned to complementation group B with concomitant changes in two markers for senescence. MORF 4 is a member of a novel family of genes with transcription factor-like motifs. We present here the sequences of the seven family members, their chromosomal locations, and a partial characterization of the three members that are expressed. Elucidation of the mechanism of action of these genes should enhance our understanding of growth regulation and cellular aging.

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43

Lafontant, Jean. "Anne LÉGARÉ et Nicole MORF, La société distincte de l'État : Québec-Canade, 1930-1980." Recherches sociographiques 31, no. 2 (1990): 265. http://dx.doi.org/10.7202/056522ar.

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44

Gong, Han-Yuan, Brett M. Rambo, Cory A. Nelson, Vincent M. Lynch, Xiaoyang Zhu, and Jonathan L. Sessler. "Rare-earth cation effects on three-dimensional metal–organic rotaxane framework (MORF) self assembly." Chemical Communications 48, no. 82 (2012): 10186. http://dx.doi.org/10.1039/c2cc34200f.

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45

Chen, Meizhen, Kaoru Tominaga, and Olivia M. Pereira-Smith. "Emerging role of the MORF/MRG gene family in various biological processes, including aging." Annals of the New York Academy of Sciences 1197, no. 1 (June 2010): 134–41. http://dx.doi.org/10.1111/j.1749-6632.2010.05197.x.

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46

Chen, Ling, Yi Wang, Dengfeng Cheng, Xinrong Liu, Shuping Dou, Guozheng Liu, Donald J. Hnatowich, and Mary Rusckowski. "99mTc-MORF oligomers specific for bacterial ribosomal RNA as potential specific infection imaging agents." Bioorganic & Medicinal Chemistry 21, no. 21 (November 2013): 6523–30. http://dx.doi.org/10.1016/j.bmc.2013.08.034.

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47

Mulyati, Sri. "Morfologis Analisis Dalam Puisi Embun Di Hutan Jati Karya Candra Malik." Wanastra: Jurnal Bahasa dan Sastra 13, no. 2 (September 30, 2021): 155–60. http://dx.doi.org/10.31294/w.v13i2.10648.

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Linguistik adalah ilmu yang mempelajari tentang bahasa, dan penggunaannya sebagai alat komunikasi. Linguistik juga mempelajari struktur bahasa dan segala aspek yang ada di dalamnya. Dalam linguistik terdapat beberapa cabang kajian ilmu di antaranya adalah: fonologi, morfologi, semantik, pragmatik, dan sintax.Morfologi adalah salah satu cabang ilmu linguistik yang memepelajari tentang seluk-beluk struktur internal kata dan pengaruh perubahan struktur tersebut terhadap arti dan golongan kata. Struktur internal kata terdiri dari satuan-satuan gramatik terkecil yang disebut morfem.Analisis ini fokus pada kajian morfem terutama morfem terikat, serta morf dan alomorf. Dengan memperdalam pengetahuan morfologi khususnya tentang morfem, diharapkan dapat meminimalisir kesalahan dalam bentuk ucaanp atau tulians saat proses komunikasi berlangsung, baik dalam lingkup formal ataupun tidak formal.Dalam puisi ”Embun Di Hutan Jati” karya Candra Malik lebih banyak didominasi morfem terikat yang berupa alomorf daripada morf. Yaitu; morfem dasar terikat, me- dan ber-.

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48

Liu, Guozheng, Shuping Dou, Stephen Baker, Ali Akalin, Dengfeng Cheng, Ling Chen, Mary Rusckowski, and Donald J. Hnatowich. "A preclinical188Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49." Cancer Biology & Therapy 10, no. 8 (October 15, 2010): 767–74. http://dx.doi.org/10.4161/cbt.10.8.12879.

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49

Champagne, Nathalie, Nadine Pelletier, and Xiang-Jiao Yang. "Monocytic leukemia zinc-finger protein MOZ and its related factor MORF are new histone acetyltransferases." Nature Genetics 27, S4 (April 2001): 97. http://dx.doi.org/10.1038/87374.

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50

Hernández-Segura, Teresa, and Nina Pastor. "Identification of an α-MoRF in the Intrinsically Disordered Region of the Escargot Transcription Factor." ACS Omega 5, no. 29 (July 17, 2020): 18331–41. http://dx.doi.org/10.1021/acsomega.0c02051.

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